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									                                                                                   1960_2008_2_S42

  Rajiv Gandhi University of Health Sciences, Karnataka
              Second year B.Pharm Degree Examination – Sept / Oct 2008
Time: Three Hours                                                            Max. Marks: 80 Marks

             PHARMACEUTICAL ORGANIC CHEMISTRY - II
                     (Revised Scheme - 2)
                                 Q.P. CODE: 1960
                      Your answers should be specific to the questions asked
                         Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two)                                                   2 x 10 = 20 Marks
1.    What are Geometrical isomers? Give examples. Add a note on stereochemistry of Oximes

2.    What are heterocyclic compounds? Classify them with examples.            Give synthesis and
      chemical properties of Pyridine
3.    What are Proteins? Classify in detail. Explain G-terminal and N-terminal analysis


SHORT ESSAYS (Answer any Eight)                                                  8 x 5 = 40 Marks
4.    What are Conformational isomers? Explain the stability of n-Butane conformers
5.    Explain the determination of Configuration of open chain structure of Glucose
6.    Give pharmaceutical applications of Cellulose and its derivatives
7.    Explain any one method of determination of Iodine value and give its significance
8.    Establish the Ring size of Glucose
9.    What are Polynuclear hydrocarbons? Classify and give Haworth’s synthesis of Naphthalene
10.   What are Drying, Semidrying and Nondrying oils? Give examples
11.   Give structure and uses of    a) Chloroquine            b) Isoniazid            c) Sulfadiazine
      d) Metronidazole      e) Pyrimethamine
12.   Give basic structure and Pharmacological applications of Phenothiazine and Benzodiazepine
13.   Give Azalactone synthesis and its mechanism


SHORT ANSWERS                                                                  10 x 2 = 20 Marks
14.   Define Fats & Oils Chemically
15.   Give the structure and uses of Sucrose
16.   What are carbohydrates?
17.   Give resonance structures of Thiophene
18.   Give structure and uses of Tolnaftate
19.   Give structure and uses of compound containing Phenanthrene nucleus
20.   Give the Strecker’s synthesis of amino acids
21.   Define optical activity
22.   Outline SN2 mechanism
23.   What are Meso compounds?
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