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Beckman Coulter
®

Kit MSDS
Doc. ID: 465145-75: Rev. AC

Product Information
Product Name Part Number Series Name: Additional Product Information:

Phosphorus Reagent
465145

Doc. ID 465145-75 AC Issued (year/month/day) Revised (year/month/day) 2005/02/21

Components
Description Phosphorus Reagent (Compartment A) Phosphorus Reagent (Compartment B)

Transport Information
Shipping Information Shipping Name UN/ID Number Packing Group IATA Hazard Class Subsidiary Risk Special Provisions IATA ERG Code IMDG Hazard Class Subsidiary Risk Special Provisions Marine Pollutant US DOT Hazard Class Subsidiary Risk Special Provisions NAERG Number European ADR ADR Classification Classification Code/ Subsidiary Risk Sulfuric acid solution 2796 II 8 Corrosives None None 8L 8 Corrosive substances None None No 8 Corrosive material None Not applicable 157 8 Corrosive substances C1 None

2005 Beckman Coulter, Inc.
Global MSDS – English

Phosphorus Reagent

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Transport Information (Continued)
Canadian TDG PIN TDG Classification Subsidiary Risk Special Provisions NAERG Number 2796 8 Corrosives None None 157

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@

Beckman Coulter
®

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

Phosphorus Reagent (Compartment A)
Component of P/N 465145

Phosphorus Reagent Doc. ID 465145-75 AC Issued (year/month/day) Revised (year/month/day) 2005/02/21

Part Number Product Use Manufacturer

For In Vitro Diagnostic Use. See product literature for details. Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92835-3100, U.S.A.

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Chemical Name Sulfuric Acid Guanidine Hydrochloride Coco Alkyl Bis(2-Hydroxyethyl)Methyl Quaternary Ammonium Chlorides Ethoxylated CAS # 7664-93-9 50-01-1 61791-10-4 % by wt. <5% <15% <5% No No C;R 35 Meets Hazardous Criteria: EU US OSHA Yes Yes Yes WHMIS Exempt Exempt Exempt

See Section 15 Regulatory Information for additional information on hazard classifications.

Section 3 Hazards Identification
Emergency Overview Colorless; Translucent; Liquid; Odorless Nonflammable aqueous solution. May be harmful or fatal if swallowed. CNS depressant. Corrosive; eye, skin burns, severe respiratory tract irritant. Physical Hazards Potential Health Effects Summary No physical hazards were determined from a review of available literature. Inhalation may cause severe irritation or burns to the respiratory tract and central nervous system depression with headache, dizziness, nausea and unconsciousness. Skin and eye contact may cause irritation or burns. Corrosive effects may be delayed. See Section 11 Toxicological Information for more detailed health information. EU: Xi;R36/38 WHMIS: Exempt US OSHA: Hazardous

Product Hazard Classifications

Phosphorus Reagent Phosphorus Reagent (Compartment A)

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Section 3 Hazards Identification (Continued)
Beckman Coulter Safety Rating Flammability (Section V): 0 Health (Section XI): 2 Reactivity with Water (Section X): 0 Contact (Section VIII): 2 Code 0=none 1=slight 2=caution 3=severe

Section 4 First Aid Measures
Inhalation Eye Contact Skin Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention. In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical attention. If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical attention.

Ingestion

Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the composition and volume of this product, combustion products generated from it are not expected to present a significant hazard. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidental Release Measures
Personal Precautions Spill and Leak Procedures Environmental Precautions Avoid skin contact. Use good laboratory procedures. Wipe up material carefully and place in container suitable for disposal. Contain spill to prevent migration.

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions Avoid inhaling, ingesting, and contact with eyes and skin. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Phosphorus Reagent Phosphorus Reagent (Compartment A)

Doc. ID: 465145-75 AC

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Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: Sulfuric Acid ACGIH: Sulfuric Acid DFG MAK: Sulfuric Acid Engineering Controls Respiratory Protection 0.1 mg/m3 MAK (inhalable fraction); 0.1 mg/m3 Peak (inhalable fraction) Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves should be worn to prevent skin contact. 3 mg/m3 STEL; 1 mg/m3 TWA 1 mg/m3 TWA

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Solubility Water Organic Miscible Not available Liquid Colorless Translucent Odorless Sulfuric Acid no geometric mean air odor threshold 1 Not available Not available 1.0856 @20°C Not available Not available Not available

Section 10 Stability and Reactivity
Stability Stable under normal temperatures and pressures.

Phosphorus Reagent Phosphorus Reagent (Compartment A)

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Section 10 Stability and Reactivity (Continued)
Hazardous Incompatibilities Strong oxidizers Strong bases Perchloric Acid Permanganates When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Keep away from incompatible material.

Hazardous Decomposition Products Conditions to Avoid

Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Sulfuric Acid Primary Routes of Exposure Potential Effects of Acute Exposure Inhalation LC50 Rat: 510 mg/m3/2H; Inhalation LC50 Mouse: 320 mg/m3/2H; Oral LD50 Rat: 2140 mg/kg The most likely routes of exposure are skin, eye contact and inhalation. Exposure to alkylbis (2-hydroxyethyl) methyl quaternary ammonium chloride by inhalation, eye, and skin contact may cause irritation. Large dose may be caustic to skin and respiratory system, and may cause eye burns and opacity. Ingestion by large dose may cause nausea, vomiting, and corrosive damage to mucous membranes. Also it may affect circulatory or central nervous system with symptoms of confusion, restlessness, hypotension, respiratory paralysis, collapse, convulsion, coma, and death. Inhalation of dilute acidic mists may cause respiratory tract irritation or burns to mucous membranes resulting in coughing, choking and difficulty in breathing. Results of skin contact may range from irritation and inflammation to burns with blistering. Eye contact may cause severe irritation with painful, watery eyes or burns with possible blindness. Ingestion may cause irritation or burns to the mouth and throat resulting in pain, difficulty in speaking and swallowing, intense thirst, nausea and vomiting. Exposure to guanidine hydrochloride by skin and eye contact may cause skin irritation and dilatation of pupil of the eyes. Inhalation may cause central nervous system depression, drunkenness, and pulmonary irritation. Ingestion may cause nausea, diarrhea, and neurological disturbance. Repeated and prolonged exposures to alkylbis (2-hydroxyl) methyl quaternary ammonium chloride by skin contact may cause allergic reactions. Depending upon concentration and duration of exposure to dilute acidic mist, effects may be similar to those described for acute exposure. Repeated or prolonged contact with dilute acid may result in dermatitis and conjunctivitis with inflamed skin and eyes. Prolonged and repeated exposure to guanidine hydrochloride in high concentration may cause general irritation to skin, eyes, respiratory and gastrointestinal systems. Symptoms of overexposure may include: throat irritation, possibly with burning sensation and coughing; dry, red, irritated skin and eyes; headache, drowsiness, dizziness, stupor, convulsions, rapid involuntary eye movement, coma and death. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Reproductive effects have been reported in animal studies. Exposure to this product may aggravate individuals with pre-existing blood, kidney, liver or respiratory system conditions.

Potential Effects of Chronic Exposure

Symptoms of Overexposure Carcinogenicity Other Effects Conditions Aggravated by Exposure

Phosphorus Reagent Phosphorus Reagent (Compartment A)

Doc. ID: 465145-75 AC

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Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility No information available. No information available. No information available.

Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information.

Section 14 Transport Information
Shipping Information Shipping Name UN/ID Number Packing Group IATA Hazard Class Subsidiary Risk Special Provisions IATA ERG Code IMDG Hazard Class Subsidiary Risk Special Provisions Marine Pollutant US DOT Hazard Class Subsidiary Risk Special Provisions NAERG Number European ADR ADR Classification Classification Code/ Subsidiary Risk Canadian TDG PIN TDG Classification Subsidiary Risk Special Provisions NAERG Number Sulfuric acid solution 2796 II 8 Corrosives None None 8L 8 Corrosive substances None None No 8 Corrosive material None Not applicable 157 8Corrosive substances C1 None 2796 8 Corrosives None None 157

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 CERCLA RG’s, 40 CFR 302.4 Sulfuric Acid is subject to reporting requirements of Section 313, Title III of SARA. Sulfuric Acid is listed. Sodium Hypochlorite is listed.

Phosphorus Reagent Phosphorus Reagent (Compartment A)

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Section 15 Regulatory Information (Continued)
US Federal and State Regulations California Proposition 65 Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK No ingredients listed Sulfuric Acid is listed. Sodium Hypochlorite is listed. Sulfuric Acid is listed. Sodium Hypochlorite is listed. Sulfuric Acid is listed. Sodium Hypochlorite is listed.

EU Labeling Classification Classification Xi Irritant Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: 2796 Sulfuric Acid Sodium Hypochlorite Product is exempt Risk and Safety Phrases R36/38 Irritating to eyes and skin.

Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.

Page 9 of 14

@

Beckman Coulter
®

MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identification

Product Name

Phosphorus Reagent (Compartment B)
Component of P/N 465145

Phosphorus Reagent Doc. ID 465145-75 AC Issued (year/month/day) Revised (year/month/day) 2005/02/21

Part Number Product Use Manufacturer

For In Vitro Diagnostic Use. See product literature for details. Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92835-3100, U.S.A.

Distributor and Emergency Phone No.

¤

Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers.

Section 2 Composition and Information on Ingredients
Hazardous Ingredients: Chemical Name Ammonium Para-Molybdate Tetrahydrate Sulfuric Acid CAS # 12054-85-2 7664-93-9 % by wt. <5% <10% No C;R 35 Meets Hazardous Criteria: EU US OSHA Yes Yes WHMIS Exempt Exempt

See Section 15 Regulatory Information for additional information on hazard classifications.

Section 3 Hazards Identification
Emergency Overview Colorless; Transparent; Liquid; Odorless Nonflammable aqueous solution. Corrosive; eye, skin burns, severe respiratory tract irritant. May be harmful or fatal if swallowed. May cause birth defects. Physical Hazards Potential Health Effects Summary Product Hazard Classifications Beckman Coulter Safety Rating No physical hazards were determined from a review of available literature. May cause skin, eye and respiratory tract irritation. Reproductive effects have been reported in several animal studies. See Section 11 Toxicological Information for more detailed health information. EU: Xi;R36/38 WHMIS: Exempt Code 0=none 1=slight 2=caution 3=severe US OSHA: Hazardous

Flammability (Section V): 0 Health (Section XI): 2 Reactivity with Water (Section X): 0 Contact (Section VIII): 2

Phosphorus Reagent Phosphorus Reagent (Compartment B)

Doc. ID: 465145-75 AC

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Section 4 First Aid Measures
Inhalation Eye Contact Skin Contact If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention. In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical attention. If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical attention.

Ingestion

Section 5 Fire Fighting Measures
Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Hazardous Combustion Products Protective Equipment for Firefighters Not applicable Not applicable Not applicable Use extinguishing media suitable for surrounding fire. No special hazards determined. Due to the composition and volume of this product, combustion products generated from it are not expected to present a significant hazard. Self-contained breathing apparatus is recommended for firefighters.

Section 6 Accidental Release Measures
Personal Precautions Spill and Leak Procedures Environmental Precautions Avoid skin contact. Use good laboratory procedures. Wipe up material carefully and place in container suitable for disposal. Contain spill to prevent migration.

Section 7 Handling and Storage
Handling Precautions Recommended Storage Conditions Avoid inhaling, ingesting, and contact with eyes and skin. Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling.

Section 8 Exposure Controls and Personal Protection
Exposure Limits US OSHA: Sulfuric Acid Ammonium ParaMolybdate Tetrahydrate Ammonium ParaMolybdate Tetrahydrate 1 mg/m3 TWA 5 mg/m3 TWA (as Mo) 15 mg/m3 TWA (total dust)

Phosphorus Reagent Phosphorus Reagent (Compartment B)

Doc. ID: 465145-75 AC

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Section 8 Exposure Controls and Personal Protection (Continued)
ACGIH: Sulfuric Acid Ammonium ParaMolybdate Tetrahydrate Ammonium ParaMolybdate Tetrahydrate DFG MAK: Sulfuric Acid Engineering Controls Respiratory Protection 0.1 mg/m3 MAK (inhalable fraction); 0.1 mg/m3 Peak (inhalable fraction) Use in well ventilated area. Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves should be worn to prevent skin contact. 3 mg/m3 STEL; 1 mg/m3 TWA 0.5 mg/m3 TWA (respirable fraction, as Mo) 10 mg/m3 TWA (inhalable fraction, as Mo); 3 mg/m3 TWA (respirable fraction, as Mo)

Eye Protection Skin Protection

Section 9 Physical and Chemical Properties
Physical State Color Transparency Odor Odor Threshold pH Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Solubility Water Organic Miscible Not available Liquid Colorless Transparent Odorless Sulfuric Acid no geometric mean air odor threshold 1 Not available Not available 1.0902 @20°C Not available Not available Not available

Section 10 Stability and Reactivity
Stability Hazardous Incompatibilities Stable in closed containers under normal temperatures and pressures. Strong oxidizers Perchloric Acid Strong bases Permanganates

Phosphorus Reagent Phosphorus Reagent (Compartment B)

Doc. ID: 465145-75 AC

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Section 10 Stability and Reactivity (Continued)
Hazardous Decomposition Products Conditions to Avoid When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Keep away from incompatible material.

Section 11 Toxicological Information
Toxicity Data for Hazardous Ingredients Sulfuric Acid Primary Routes of Exposure Potential Effects of Acute Exposure Inhalation LC50 Rat: 510 mg/m3/2H; Inhalation LC50 Mouse: 320 mg/m3/2H; Oral LD50 Rat: 2140 mg/kg The most likely routes of exposure are skin, eye contact and inhalation. Inhalation of dilute acidic mists may cause respiratory tract irritation or burns to mucous membranes resulting in coughing, choking and difficulty in breathing. Results of skin contact may range from irritation and inflammation to burns with blistering. Eye contact may cause severe irritation with painful, watery eyes or burns with possible blindness. Ingestion may cause irritation or burns to the mouth and throat resulting in pain, difficulty in speaking and swallowing, intense thirst, nausea and vomiting. Exposure to ammonium para-molybdate by inhalation, eye or skin contact may cause irritation to respiratory tract, eyes, or skin. Additional effect may include tearing eyes and dehydration. Depending upon concentration and duration of exposure to dilute acidic mist, effects may be similar to those described for acute exposure. Repeated or prolonged contact with dilute acid may result in dermatitis and conjunctivitis with inflamed skin and eyes. Prolonged and repeated exposure to ammonium para-molybdate by inhalation and skin contact may cause injurious effect including gout. Ingestion of large doses may cause difficult breathing, colic, gout, trembling, loss of appetite and anemia; possible deformities of forelegs in animals. The body levels of copper and zinc may affect the toxicity. Symptoms of overexposure may include: redness, burning and watering of the eyes; dry, red, cracked skin; coughing and difficult breathing; nausea and vomiting. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Reproductive effects have been reported in animal studies. Exposure to this product may aggravate individuals with pre-existing blood, kidney, liver or respiratory system conditions.

Potential Effects of Chronic Exposure

Symptoms of Overexposure Carcinogenicity Other Effects Conditions Aggravated by Exposure

Section 12 Ecological Information
Ecotoxicity Biodegradability Mobility No information available. No information available. No information available.

Section 13 Disposal Considerations
Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information.

Phosphorus Reagent Phosphorus Reagent (Compartment B)

Doc. ID: 465145-75 AC

Page 13 of 14

Section 14 Transport Information
Shipping Information Shipping Name UN/ID Number Packing Group IATA Hazard Class Subsidiary Risk Special Provisions IATA ERG Code IMDG Hazard Class Subsidiary Risk Special Provisions Marine Pollutant US DOT Hazard Class Subsidiary Risk Special Provisions NAERG Number European ADR ADR Classification Classification Code/ Subsidiary Risk Canadian TDG PIN TDG Classification Subsidiary Risk Special Provisions NAERG Number Sulfuric acid solution 2796 II 8 Corrosives None None 8L 8 Corrosive substances None None No 8 Corrosive material None Not applicable 157 8Corrosive substances C1 None 2796 8 Corrosives None None 157

Section 15 Regulatory Information
US Federal and State Regulations SARA 313 CERCLA RG’s, 40 CFR 302.4 California Proposition 65 Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK Sulfuric Acid is subject to reporting requirements of Section 313, Title III of SARA. Sulfuric Acid is listed. No ingredients listed Sulfuric Acid is listed. Ammonium Para-Molybdate Tetrahydrate is listed. Sulfuric Acid is listed. Ammonium Para-Molybdate Tetrahydrate is listed. Sulfuric Acid is listed. Ammonium Para-Molybdate Tetrahydrate is listed.

Phosphorus Reagent Phosphorus Reagent (Compartment B)

Doc. ID: 465145-75 AC

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Section 15 Regulatory Information (Continued)
EU Labeling Classification Classification Xi Irritant Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: 2796 Sulfuric Acid Product is exempt Risk and Safety Phrases R36/38 Irritating to eyes and skin.

Section 16 Other Information
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.


				
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