"The knowledge becomes learning when pedagogy comes into play". Taking this as our starting-point, we can construct the paragraphs that sustain this guide,trying to be an an instrument, a support tool when we propose to transform knowledge into learning. The team, which has participated in its elaboration, has always aimed to design a real material suitable for different teaching realities. The goal of innovating teaching methods application can be extrapolated to any reality in which tthe learning, either formal, not formal or informal, is carried out along our life at any moment. They will be possible users of this guide: professional teachers which want to innovate and carry out new alternative teaching methods; company teachers which want to replace traditional methods and want to meet the needs required by the new business environment; organizations which want incorporate e-learning as a way of learning innovation; university professors which stand for innovation as a way to adapt to Europe and the new knowledge society requests; institutions and organizations which use ICT's for teaching learning. Finally for everybody that needs to learn to learn which are the new rules or the 21 th century environment".