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					           Reducing the Risk of Breast Cancer
                     Seehusen DA, Edwards JA, Junnila JL, Oh RC, Runkle GP
                                 Madigan Army Medical Center
    Does tamoxifen reduce breast cancer risk in women with a family history of colon cancer?

                                                          5 year Breast Cancer Mortality
Methods:
•     Double-blinded, placebo-
      controlled randomized trial
                                                                              Control
•     Intervention: Tamoxifen 20mg
      daily for five years
•     10,000 subjects enrolled
                                                                            Tamoxifen

                                                                                   (per 5,000 subjects))


       Background:
                                                         Results:
       •   Tamoxifen effective in
           breast cancer prevention                      50% reduction in 10 year risk of breast
                                                            cancer in women ages 40-59 with a
       •   Family History of colon
                                                            first degree relative with colorectal
           cancer increases risk
                                                            adenocarcinoma treated with
                                                            prophylactic tamoxifen
      Reducing the Risk of Breast Cancer: Taking 20mg of Tamoxifen daily
      for 5 years will reduce the 10 year risk of breast cancer in women
     ages 40-59 with a first degree relative of colorectal adenocarcinoma
                                by 50 percent.

Runkle GP ,Seehusen DA, Edwards JA, Junnila JL, Oh RC
                               Madigan Army Medical Center

                                                                                   Methods:
                                                                                   Double-blinded, placebo-controlled
                                                                                      randomized trial
                                                                                   Intervention: Tamoxifen 20mg daily for
          In this enterprising study, the authors demonstrated a fifty percent
                reduction in the ten year actuary survival rate in the incidence        five years
                of breast cancer in women ages 40-59 with a first degree           10,000 subjects enrolled
                relative with colorectal adenocarcinoma treated with
                prophylactic tamoxifen at a dose of twenty milligrams daily for
                a total of five years of administration with minimal loss to
                follow-up.


   Tamoxifen effective in breast cancer prevention
   Family History of colon cancer increases risk

   Does tamoxifen reduce breast cancer risk in women with a family history of colon cancer?

				
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posted:4/19/2011
language:English
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