Neurology Department Athens General Hospital « G.Gennimatas »
Kyrimi V., Nikolaou G., Maroussi S., Stathopoulos P., Alexoudi A., Mezili A.,
Soldatos Th., Giannouli E., Doumos J., Papageorgiou H., Karageorgiou C.E.
The significance of neuroimaging in the diagnosis of
Creutzfeldt-Jacob disease (CJD).
Introduction: Creutzfeldt Jacob disease (CJD), a progressive neurodegenerative
disorder, has diagnostic biomarkers, CSF protein 14-3-3, total tau and neuron specific
enolase, of inadequate diagnostic value. The last years the role of diffusion-weighted
magnetic resonance imaging (DWI) has been examined.
Aim of the study: The aim of the study is to determine the possible valuable role of
neuroimaging for the diagnosis of CJD.
Patients and methods: This study retrospectively examines the patients with CJD
that were hospitalized during the last 5 years in the neurological department of
G.Gennimatas Athens General Hospital. All patients were examined by a neurologist
the first day of their hospitalization. In addition, EEG, brain MRI with DWI, and
lumbar puncture for the detection of tau protein and protein 14-3-3 were performed.
The patients were hospitalized and followed clinically and by means of laboratory
exams until the time of their death.
Results: All data were evaluated and a comparison was made between their clinical
and neuroimaging profile. All patients were diagnosed in our department. In many
cases the DWI could help the early diagnosis of CJD.