Lung Cancer or Bronchogenic Cancer

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Lung Cancer or Bronchogenic Cancer Powered By Docstoc
					Lung Cancer
   -   Also called bronchogenic cancer
   -   Is a disease of uncontrolled cell growth in tissues of the lung which may lead to
   -   Is the most common cause of cancer-related death in men and women, is
       responsible for 1.3 million deaths worldwide annually, as of 2004

Types of lung cancer

Doctors divide lung cancer into two major types based on the appearance of lung cancer
cells under the microscope. The doctor makes treatment decisions based on which major
type of lung cancer one has. The two general types of lung cancer include:
     Small cell lung cancer. Small cell lung cancer occurs almost exclusively in
        heavy smokers and is less common than non-small cell lung cancer.

       Stages of non-small cell lung cancer

          Stage I. Cancer at this stage has invaded the underlying lung tissue but hasn't
           spread to the lymph nodes.
          Stage II. This stage cancer has spread to neighboring lymph nodes or invaded
           the chest wall or other nearby structures.
          Stage IIIA. At this stage, cancer has spread from the lung to lymph nodes in
           the center of the chest.
          Stage IIIB. The cancer has spread locally to areas such as the heart, blood
           vessels, trachea and esophagus — all within the chest — or to lymph nodes in
           the area of the collarbone or to the tissue that surrounds the lungs within the
           rib cage (pleura).
          Stage IV. The cancer has spread to other parts of the body, such as the liver,
           bones or brain.

      Non-small cell lung cancer. Non-small cell lung cancer is an umbrella term for
       several types of lung cancers that behave in a similar way. Non-small cell lung
       cancers include squamous cell carcinoma, adenocarcinoma and large cell

       Stages of small cell lung cancer

          Limited. Cancer is confined to one lung and to its neighboring lymph nodes.
          Extensive. Cancer has spread beyond one lung and nearby lymph nodes, and
           may have invaded both lungs, more-remote lymph nodes, or other organs,
           such as the liver or brain.

Signs and Symptoms

      dyspnea (shortness of breath)
      hemoptysis (coughing up blood)
        chronic coughing or change in regular coughing pattern
        wheezing
        chest pain or pain in the abdomen
        cachexia (weight loss), fatigue, and loss of appetite
        dysphonia (hoarse voice)
        clubbing of the fingernails (uncommon)
        dysphagia (difficulty swallowing)


        Smoking
        Radon Gas
        Asbestos
        Viruses
        Particulate Matter

Risk Factors

        Smoking
        Exposure to secondhand smoke
        Exposure to radon gas
        Exposure to asbestos and other chemicals
        Family history of lung cancer
        Excessive alcohol use
        Certain lung diseases


        Shortness of breath
        Hemoptysis (coughing up blood)
        Pain
        Pleural effusion (fluid in the chest)
        Metastasis
        Death

Screening refers to the use of medical tests to detect disease in asymptomatic people.
Possible screening tests for lung cancer include chest radiograph or computed
tomography (CT). As of December 2009, screening programs for lung cancer have not
demonstrated any benefit.

Tests and Diagnosis

        Imaging tests – x-ray
        Sputum cytology
        Biopsy
Treatment and Drugs

        Surgery
          o Wedge resection to remove a small section of lung that contains the tumor
              along with a margin of healthy tissue
          o Segmental resection to remove a larger portion of lung, but not an entire
          o Lobectomy to remove the entire lobe of one lung
          o Pneumonectomy to remove an entire lung

        Chemotherapy – uses drugs to kill cancer

        Radiation Therapy – Radiation therapy uses high-powered energy beams, such as
         X-rays, to kill cancer cells.
          o External beam radiation – Radiation therapy directed at the lung cancer
              from outside the body
          o Brachytherapy – Radiation put inside needles, seeds or catheters and
              placed inside the body near the cancer

        Targeted Drug Therapy – Targeted therapies are newer cancer treatments that
         work by targeting specific abnormalities in cancer cells. Targeted therapy options
         for treating lung cancer include:
             o Bevacizumab (Avastin). Bevacizumab stops a tumor from creating a new
                 blood supply. Blood vessels that connect to tumors can supply oxygen and
                 nutrients to the tumor, allowing it to grow. Bevacizumab is usually used in
                 combination with chemotherapy and is approved for advanced and
                 recurrent non-small cell lung cancer. Bevacizumab carries a risk of
                 bleeding, blood clots and high blood pressure.
             o Erlotinib (Tarceva). Erlotinib blocks chemicals that signal the cancer
                 cells to grow and divide. Erlotinib is approved for people with advanced
                 and recurrent non-small cell lung cancer that haven't been helped by
                 chemotherapy. Erlotinib side effects include a skin rash and diarrhea.

                   Treatment options for non-small cell lung cancers
Stage       Common options
I           Surgery, sometimes chemotherapy
II          Surgery, chemotherapy, radiation
            Combined chemotherapy and radiation, sometimes surgery based on results of
IIIB        Chemotherapy, sometimes radiation
IV          Chemotherapy, targeted drug therapy, clinical trials, supportive care
                      Treatment options for small cell lung cancers
Stage       Common options
Limited     Combined chemotherapy and radiation, sometimes surgery
Extensive Chemotherapy, clinical trials, supportive care


There's no sure way to prevent lung cancer, but you can reduce your risk if you:

        Don't smoke
        Stop smoking
        Avoid secondhand smokeTest your home for radon
        Avoid carcinogens at work
        Eat a diet full of fruits and vegetables
        Drink alcohol in moderation, if at all
        Exercise


        New or changing cough, dyspnea, wheezing, excessive sputum production,
         hemoptysis, chest pain (aching, poorly localized), malaise, fever, weight loss,
         fatigue, or anorexia.
        Decreased breath sounds, wheezing, and possible pleural friction rub (with pleural
         effusion) on examination.

Nursing Interventions

     1. Elevate the head of the bed to ease the work of breathing and to prevent fluid
        collection in upper body (from superior vena cava syndrome).
     2. Teach breathing retraining exercises to increase diaphragmatic excursion and
        reduce work of breathing.
     3. Augment the patient’s ability to cough effectively by splinting the patient’s chest
     4. Instruct the patient to inspire fully and cough two to three times in one breath.
     5. Provide humidifier or vaporizer to provide moisture to loosen secretions.
     6. Teach relaxation techniques to reduce anxiety associated with dyspnea. Allow the
        severely dyspneic patient to sleep in reclining chair.
     7. Encourage the patient to conserve energy by decreasing activities.
     8. Ensure adequate protein intake such as milk, eggs, oral nutritional supplements;
        and chicken, fowl, and fish if other treatments are not tolerated – to promote
        healing and prevent edema.
     9. Advise the patient to eat small amounts of high-calorie and high-protein foods
        frequently, rather than three daily meals.
 10. Suggest eating the major meal in the morning if rapid satiety is the problem.
 11. Change the diet consistency to soft or liquid if patient has esophagitis from
     radiation therapy.
 12. Consider alternative pain control methods, such as biofeedback and relaxation
     methods, to increase the patient’s sense of control.
 13. Teach the patient to use prescribed medications as needed for pain without being
     overly concerned about addiction.

Cross section of a human lung. The white area in the upper lobe is cancer; the black areas are
                               discoloration due to smoking.
Chest radiograph showing a cancerous tumor in the left lung.

    CT scan showing a cancerous tumor in the left lung