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									                                     JOB DESCRIPTION

POST TITLE:                         NIHR IAT Clinical Lecturer in Obstetrics and Gynaecology

DEPARTMENT:                         Warwick Medical School

SUB-DEPARTMENT:                     Clinical Sciences Research Institute

POST RESPONSIBLE TO:                Professor Steve Thornton, Associate Dean (Research)

SALARY:                             £30,685 - £40,745 pa

REFERENCE NUMBER:                   37412-069

CONTRACT:                           Fixed term for three years
CLOSING DATE:                       17 July 2009

INTERVIEW DATE:                     29th July 2009


To undertake high quality research, clinical work, teaching and administration in obstetrics
under the direction of Professor S. Thornton (Obstetrics and Gynaecology).

The post is intended for a specialist trainee in obstetrics & gynaecology wishing to undertake
a period of further training and research in obstetrics; participation in teaching
undergraduates will be expected. You will be based at Warwick Medical School and the
clinical department of Obstetrics & Gynaecology at the University Hospitals Coventry &
Warwickshire NHS Trust (UHCW). Teaching and research will take place in both the clinical
sciences building on the hospital site and Warwick Medical School (WMS) on the University
of Warwick campus.

You will be employed by the University of Warwick and hold an honorary contract with


Provisional timetable for the new post

                  Activity                                        Sessions

Research/Academic/Teaching                                            5

Clinical                                                              5
1. Research Activities in Obstetrics & Gynaecology

You will participate actively in reproduction research including myometrial contractility, high
quality physiological and pathophysiological investigations and / or clinical trials.

The Department of Obstetrics & Gynaecology encompasses multidisciplinary research across
a range of important issues in reproductive health. There are currently 17 full time scientific
and clinical staff; we have published in journals such as Nature, Journal of Physiology, The
Lancet, American Journal of Physiology, American Journal of Obstetrics and Gynaecology
and Human Reproduction. The group has attracted external funding from numerous sources
including MRC, BBSRC, the Wellcome Trust, the Sir Jules Thorn Charitable Trust, Wellbeing
and Action Medical Research, current active grants exceed £5 million. Our research areas
include the investigation of myometrial contractility, stem cell biology, the genetics of human
gametes, dissection of the cellular and molecular basis of reproductive tissue function and
early human embryo development. You will link to our work in myometrial contractility and
preterm labour. Clinical and laboratory programmes are based in UHCW (West Wing),
Centre for Reproductive Medicine and WMS at the University of Warwick. There are also
collaborations with other departments in the University and with researchers outside

2. Research/Academic/Teaching

You will be expected to be actively involved in the undergraduate and postgraduate teaching
programme. New state of the art teaching facilities are available on the University and UHCW
campus. Complementary facilities, including skills laboratories, are available in UHCW.

3. Clinical

The specific duties of the post will focus on obstetrics and will include participation in the
specialist registrar on call rota for obstetrics. The precise details of the weekly schedule and
on call commitment will be subject to discussion with the Clinical Director and research
supervisor. On call is generally carried out on a full shift basis.

The clinical duties will include a full range of clinical activity. Clinical duties will be based in the
Women‟s Hospital, UHCW NHS Trust. Clinical responsibilities will include five clinical
sessions. Specialist work will be undertaken according to the post.
                               PERSON SPECIFICATION

POST TITLE:             NIHR Clinical Lecturer in Obstetrics & Gynaecology

DEPARTMENT:             Warwick Medical School, Clinical Sciences Research Institute

The Person Specification focuses on the knowledge, skills, experience and qualifications required to
undertake the role effectively.

REQUIREMENTS                                           ESSENTIAL (E) or        MEASURED BY:
The post holder must be able                            DESIRABLE (D)         a) Application
to demonstrate:                                        REQUIREMENTS           Form
                                                                              b) Test/Exercise
                                                                              c) Interview
                                                                              d) Presentation

MBChB or equivalent                                             E                      a)

Research interest and evidence of research                      E                   a), c), d)
activity in obstetrics
A desire to pursue further training in obstetrics               E                      c)

Appropriate level of clinical knowledge                         E                    a), c)

GMC registration                                                E                      a)

Communication skills                                            E                      c)

Ability to work in multi-disciplinary team                      E                    a), c)

IT skills                                                       E                    c), d)

Interpersonal skills                                            E                      c)

A higher degree (MD/PhD) or close to completion                 E                    a), c)

MRCOG and at least a year of recognised SpR                     D                      a)
A good publication record                                       D                      a)

A demonstrable ability for obtaining research                   D                      a)

Contact Details

Candidates are welcome to visit the Department of Obstetrics and initial contact should be
made with:

Professor Steve Thornton, Professor of Obstetrics and Associate Dean (Research), Obstetrics
and Gynaecology Department, UHCW NHS Trust, Clifford Bridge Road, Coventry CV2 2X.
(Tel: mobile: 07771-747277)
                                  FURTHER PARTICULARS

Please note: Due to the nature of this role, the successful applicant will be required to
undergo enhanced level Criminal Records Bureau clearance before commencing work with
the University. Clearance obtained via another institution or body cannot be transferred.

The successful applicant will also be required to undergo a Pre Employment Medical Check
before commencing work with the University. This will involve a medical history questionnaire
and may also require an appointment with a member of the University‟s Occupational Health

In accordance with the national agenda in higher education to modernise pay and grading
structures, the University of Warwick has completed a significant programme of change that
has seen the introduction of a new pay spine and single job evaluation scheme. The work
commenced in September 2004 and was communicated and implemented across the
University in August 2006.

All salaries detailed within this recruitment document are post implementation and will be
subject to normal salary progression as defined by the relevant terms and conditions of

In conjunction with this, the University is now commencing discussions with trade unions to
harmonise terms and conditions. Further details on this phase of the project will be available


The main administrative and clinical hub of the obstetrics and gynaecology service is based in
the Department of Obstetrics and Gynaecology and Centre for Reproductive Medicine, both
on the UHCW campus.          Research is based in the Clinical Sciences Research Institute
(CSRI) and the Centre for Reproductive Medicine. The CSRI was opened in 2004 and
provides a suite of laboratories and administrative facilities to support research in cellular and
molecular biology. Reproduction, encompassing obstetrics, stem cell biology and reproductive
medicine is one of the major research themes at the University of Warwick. The post holder
will be supported in establishing an internationally competitive research programme and there
are opportunities to collaborate with a number of other clinicians and scientists within the
Medical School and other University Departments. There are excellent facilities for basic
science, social, epidemiological, psychological and health sciences research located in
Biological Sciences, Health Sciences Research Institute (WMS) and the Faculty of Social

The academic personnel in reproduction are:

       Consultant Staff               S. Thornton (Professor of Obstetrics)
                                      S. Keay (Associate Professor – clinical)
                                      M. Vatish (Associate Professor – clinical)
                                      A. Parsons (Associate Professor – clinical)
                                      R. Kennedy (Hon Associate Professor and Consultant)

       Associated Staff
                                      S. Astle (WMS Fellow)
                                     A. Blanks (RCUK fellow)
                                     G Bru-Mercier (Research fellow)
                                     G. Ladds (Non clinical Assistant Professor)
                                     A Shmygol (Non clinical Associate Professor)
                                     2 PhD Students & Technician

                                     J. St John (Professor – non clinical)
                                     Dr. H. Randeva (Associate Clinical Professor in

                                     Professor Maj Hulten (Reproductive Genetics, Warwick)
                                     Professor Dimitris Grammatopoulos (Senior Biochemist)
                                     G. Hartshorne (Professorial Fellow and Scientific
                                     Director, CRM)

The University of Warwick

The University of Warwick is arguably the most successful of UK universities founded within
the past half-century, and has earned an outstanding reputation both for research and
teaching. Warwick is comfortably ranked within the top ten of all UK university newspaper
rankings including 6th in the most recent Sunday Times Good University Guide. It was also
ranked 7th in the RAE 2008.

Founded in 1965 Warwick has been a unique and uniquely successful British university
combining a “can-do” entrepreneurial spirit with a commitment to absolute academic
excellence. Professor Nigel Thrift, Warwick‟s 5th Vice-Chancellor, was appointed in 2006 to
transform the University from a leading university within the UK to become one of the world‟s
top 50 universities by 2015. A new university strategy has been launched as a result of
extensive consultation with staff, students and Warwick‟s many external stakeholders, and is
making good progress.

Warwick employs over 5,000 members of staff, of whom 2,400 are academic and research
staff spread across 28 academic departments and 30 research centres; 91% of the academic
staff are in departments with research ratings of 5 or 5*. Of the 24 departments assessed
under the subject review process, 22 were rated excellent (or scored 21 or more out of 24) for
teaching quality.

The University of Warwick has a total student population of 17,000 (full-time equivalent) of
whom approximately 11,000 are undergraduates and 7,000 are postgraduates. Nearly one-
quarter of Warwick‟s students are international, helping to create a vibrant and cosmopolitan
campus environment which is valued and celebrated by the University.

The University‟s campus, located on a 400-acre site spanning the south west boundary of
Coventry and the county of Warwick, has an open and pleasant outlook and was voted “Best
University Campus” in a national student poll published by the Times Higher Education
Supplement in 2006. The campus offers excellent sporting facilities, including a swimming
pool, a newly refurbished gym, a climbing wall, an all weather running track and acres of
football and rugby pitches. An indoor tennis centre has recently been opened. The
renowned Warwick Arts Centre is the largest outside London with the Mead Gallery showing
visiting collections of contemporary art, a concert hall, two theatres and a cinema.

The University of Warwick is ideally placed for easy access to London (just over one hour on
the train), close to the picturesque towns of Warwick, Kenilworth and Leamington Spa and
about 45 minutes from the centre of Birmingham. The University is in the heart of
Shakespeare‟s Warwickshire with historic Stratford-upon-Avon, the Royal Shakespeare
Company and the Cotswolds all within easy reach.

The University of Warwick has a turnover approaching £350 million. The University continues
to invest heavily in its campus infrastructure and environment and its future capital plan
includes: a new student union building; a 500 bed student residency; new hotel
accommodation for visiting academics; a refurbishment of the Library; a further extension to
the Warwick Business School; and a state of the art Warwick Digital Laboratory, the
foundation stone for which was laid by Prime Minister Gordon Brown in May 2007. Capital
investment in the next year alone will total £35 million.

Further details about the University of Warwick can be found at

The Managerial and Administrative Structure of the University

The University‟s administrative and managerial structure is headed by the Vice-Chancellor,
supported by the Deputy Vice-Chancellor, the Registrar, the Deputy Registrar and the
Finance Director. However, as with all such structures, the informal lines of decision making
and the sharing of responsibility for planning and strategy flatten the hierarchy. Institutional
level decisions are initially made by a group comprising academics and administrators who
form the Senate Steering Committee which operates much along the lines of a weekly cabinet
for the University.
The Registrar, Mr Jon Baldwin, is responsible for the administration of the University and is
supported in this task by a team of Senior Officers, each of whom is responsible for a key
area and associated offices of University administration: the Academic Registrar, the Estates
Director, the Director of Personnel Services, the Director of Campus Affairs, the Director of IT
Services, the Director of Communication and Strategy, the Director of the International Office,
the Director of Research Support Services and the University Librarian. A number of office
heads and directors report in turn to these Senior Officers. To ensure overall co-ordination
between and across the University‟s administration, all administrative posts within academic
departments have a “dotted line” reporting to the University Registrar as well as the
Department in which they are based.

Warwick Medical School (WMS)

Dean WMS: Professor Yvonne Carter, OBE MBBS MD FRCGP FMedSci
Vice-Dean WMS: Professor Martin Underwood, MD FRCGP

The Medical School at Warwick was established in 2000 as part of an expansion in the
number of Medical School‟s nationally to deliver the additional capacity needed to support the
Government‟s plan to increase the number of UK trained medical graduate‟s joining the NHS.

In its first RAE submission WMS was ranked 10th for Health Services Research and 19th for
Other Hospital Clinical Subjects. This is an excellent result for a new medical school. Our
aim is to be rate in the top 5-10 in each unit of assessment in the forthcoming Research
Excellence Framework.

The School is organised in three Institutes, the Institute of Clinical Education (ICE) which is
the base for all the School‟s educational programmes, the Clinical Sciences Research
Institute (CSRI), home for our biomedical and acute hospital-based research groups, and
Health Sciences Research Institute (HSRI) which focuses on research in the community-
based clinical disciplines.
The School‟s principal clinical partners are University Hospitals Coventry and Warwickshire
NHS Trust (UHCW), the George Eliot Hospital NHS Trust, South Warwickshire General
Hospitals NHS Trust, Coventry Teaching Primary Care Trust and the other Primary Care
Trusts within Warwickshire. Additional clinical placements are provided by Worcestershire
Acute Hospitals NHS Trust, Worcestershire Mental Health Partnership NHS Trust and by a
number of general practices throughout the West Midlands. At UHCW, a state of the art PFI
hospital provides an optimal environment to support both research and education at the Trust.
The Clinical Sciences Building and the Clinical Sciences Research Institute are based on the
UHCW site and provide a base for education and laboratory research for the Medical School.

The Medical School‟s research is focused around a number of multi-disciplinary and cross-
specialty teams; collaboration within and outside School and University is encouraged and
investigators are encouraged to work across traditional disciplinary boundaries in innovative

WMS works closely with many departments across the University for both our research and
education programmes; these include the Department of Biological Sciences, the School of
Health and Social Studies, the Department of Sociology, the Department of Statistics,
Warwick Business School, Warwick Manufacturing Group, Complexity Science, Centre for
Systems Biology, the Law School and the Department of Mathematics.

Institute of Clinical Education (ICE)

The Institute of Clinical Education has three core functions delivering undergraduate medical
education, postgraduate education including research degrees, and research on
clinical/health professional education. Professor Jill Thistlethwaite, the Director of the
Institute, leads a team comprising three directorates covering specific portfolios. These are
the Directorate for Masters-level Accredited Courses and continuing professional
development (Director: Dr Adrian Stokes); the Directorate for MBChB Graduate-entry course
(Director: Dr Jane Kidd), and the Directorate for Research Degrees (Director: Dr Frances
Griffiths). The Director of Quality Assurance, Dr Paul O‟Hare, has a remit across all areas of
the Institute. Professor Neil Johnson, as Associate Dean for teaching, has an overarching
role across this Institute.

WMS is very active in the provision of postgraduate and continuing professional development
programmes. The university has a long history of involvement in postgraduate medical
education and CPD for health professionals, particularly in the fields of diabetes (Warwick
Diabetes Care), community child health, health information science and sexual health.
Postgraduate provision has been consolidated, strengthened and expanded through the
formation of the medical school.

The school provides a number of entry routes into postgraduate study. Students can initially
register for our flexible master‟s programme in health sciences which allows students to
select their own combination of modules from the wide range on offer to build sufficient credit
for the award of a master‟s degree. We also offer masters programmes in diabetes, public
health, implant dentistry, child health, sexual and reproductive health, orthopaedics,
philosophy and ethics of mental health, palliative care, medical education, and health services
management. We offer short courses both accredited and non-accredited in areas such as
diabetes care, occupational health, and clinical systems improvement. Collaborations with
other departments include the Postgraduate Diploma in Regulatory Occupational Health and
Safety for HSE Inspectors.

The Institute is developing a number of strands of research in clinical education. Particular
areas of interest are clinical and communication skills education, values-based practice,
interprofessional education, patient involvement and service improvement, professionalism
and the professional development experiences of health professionals.

The undergraduate MB ChB course at Warwick is a four-year graduate entry programme
which requires entrants to already have a first degree in biological sciences or a similar
subject. The initial element of the course (Phase 1) lasts for 18 months and provides a
foundation in the clinical and social sciences with some elements of clinical experience. This
is followed by Phase 2 which is organised as a series of clinical placements in local NHS
organisations, including four local hospitals and 30 local practices, lasting for 36 months. The
annual intake to the MB ChB programme is 164 home students and 14 overseas students
and the vast majority of our students‟ progress to foundation training posts in local West
Midlands NHS Trusts following their graduation.

The MB ChB course is based in the purpose-designed medical teaching building. Dr Jane
Kidd is Reader in Communication Studies, and Director of Undergraduate Education, working
closely with Dr Philip McTernan, who co-ordinates Phase 1 teaching, and Dr Colin
MacDougall, the Phase 2 co-ordinator. Dr Vinod Patel is Reader in Clinical Skills: the
curriculum places emphasis on the horizontal integration of clinical skills teaching with
communication skills as well as the vertical integration of early learning and patient contact
with later Phase 2 teaching (it is for this reason that clinicians are involved in the Phase 1
teaching alongside their basic scientist colleagues). Ms Deborah Markham (FRCS), and Dr
Mandy Barnett are Associate Clinical Professors in Medical Education, and Dr Ann Jackson is
Associate Professor in Interprofessional Education. Professor Peter Abrahams as Professor
of Clinical Anatomy is developing integrated clinical anatomy teaching across clinical
specialities. Dr David Davies is Reader in E-Learning. The School is very active in the
International Virtual Medical School (IVIMeds) collaboration.

At Warwick Medical School particular emphasis is placed on developing professionalism in
medical education. Professor Bill Fulford and colleagues in Philosophy of Mental Health have
been developing the concepts of values-based practice, working to provide doctors and
medical students with a system of decision support which considers the values of patients
and colleagues and which works in a way complementary to evidence-based practice.

Community education comprises learning in general practices across Coventry and
Warwickshire PCTs and beyond. An active network of practices, GP tutors, and practice
teachers is involved with undergraduate students throughout their course. There are 10 GP
Senior or Principal Clinical Fellows in Medical Education employed at WMS and three GP
Associate Clinical Professors. Interprofessional learning is an active partnership with
University of Coventry and Faculty Development is led by a learning and teaching specialist.

A recent collaboration sees Best Evidence Medical Education (BEME) establishing on the
Warwick Medical School site under the leadership of Professor Marilyn Hammick.

The Health Sciences Research Institute

Director – Professor Sarah Stewart-Brown

The Health Sciences Research Institute comprises the disciplines of public health, primary
care, statistics, health economics and rehabilitation as well as the medical specialities of
general practice, psychiatry, emergency medicine and community child health. It includes
Warwick Clinical Trials Unit which supports intervention trials throughout the medical school.
The Institute has strong links with the NHS through the local Primary Care Trusts, the West
Midlands Deanery and the Regional Public Health Office. It also has strong links with the
Clinical Sciences Research Institute and Institute of Clinical Education, with other Warwick
University Departments, particularly the School of Health and Social Studies, and with local
Universities including Leicester, Coventry and Birmingham.

The Institute‟s research programme covers new and emerging areas of health research and
key health priorities. At present there are three main research groups: - one of which covers
public health, epidemiology, psychiatry, child health, and e-health, particularly the role of the
internet in healthcare; the second primary care, primary secondary care interface and health
care systems; and the third clinical trials with a focus on emergency care, rehabilitation and
cancer. The three groups are closely integrated and members work collaboratively across all
three groups. Key research topics include:

      Cardiovascular disease and diabetes risk factors and preventive programmes
       including promotion of physical activity and healthy eating, prevention of hypertension
       and screening for hypercholesterolemia and the emerging burden of cardiovascular
       disease in developing countries.
      Public mental health including the impact of life course determinants, social
       inequalities and the built environment, aetiology and risk factors, links with physical
       health and preventive interventions.
      Emergency care, rehabilitation and prevention of injury and musculoskeletal problems.
      Management of chronic illness with a focus on decision making and patient
      Cancer prevention and management.

Clinical Sciences Research Institute (CSRI)

The Clinical Sciences Research Institute (CSRI) of WMS is a centre for research into
strategic areas of human health. The work of the Institute ranges from molecular and cellular
biology to patient-orientated physiological approaches and is based around the major
research themes of Metabolic Health (including diabetes, obesity, cardiovascular medicine
and endocrinology), Reproduction (reproductive biology and reproductive medicine),
Orthopaedics and Clinical Effectiveness. CSRI has 35 full-time academics, ~20 research
fellows, ~15 postdoctoral fellows and ~45 postgraduate students working in new, purpose-
built laboratories equipped with the latest instrumentation. There are more than 60 externally-
funded projects external currently underway at CSRI, with a total value exceeding £8.7
million. WMS signed a strategic partnership agreement with the Medical Research Council in
2007, the first new medical school to do so. This has already resulted in a Strategic Chair
appointment and a new Doctoral Training Centre with the Department of Biological Sciences.

CSRI is sited at the recently completed University Hospital of Coventry and Warwickshire
(UHCW), providing an interface for patient-orientated research. Translational Medicine is a
key element in our research approach and we have recently developed a major collaboration
with the University of Birmingham under the Science Cities initiative and funded by the
Regional Development Agency in the West Midlands.

Further     information     about     research         at     CSRI       is     available      at

Metabolic Health
Obesity, Type-2 diabetes and hyperglycaemic damage
The mechanisms relating obesity to the major associated pathologies (type-2 diabetes,
cardiovascular disease) are being studied using multi-disciplinary approaches. The neural
circuits involved in the regulation of body weight and satiety are being studied by the
neurophysiology group (led by Prof D Spanswick). The work of Prof S Kumar is aimed at
discovering the mechanisms that link sub-clinical inflammation, the development of obesity
and the aetiology of tye-2 diabetes. The effects of insulin on adipose tissue function are
being studied to elucidate mechanisms through which the hyperinsulinaemia of the pro-
diabetic state affects adipokine secretion (Dr P McTernan, Dr G Tripathy, and RCUK Fellow).
The enzymology of the pathways of fatty acid metabolism in the aetiology of insulin resistance
is being studied by the group of Prof V A Zammit. The effects of the hyperglycaemia that
accompanies poorly controlled diabetes on protein modification are studied by Prof P
Thornalley and his group, which specialises in the use of mass spectrometry in the study of
protein damage and impaired insulin signalling in a programme of research shared with
Systems Biology. Prof A Ceriello studies the effects of post-prandial hyperglycaemia on
endothelial function, particularly nitric oxide-dependent processes.

Clinical studies are being conducted into the molecular basis of the monogenic forms of
diabetes, the phenotype of LADA in Indo-Asian type-2 diabetic patients, and the effects of
different treatments for type-2 diabetes on clinical outcomes, and the role of ethnicity in
determining these outcomes. The UK Asian Diabetes Study investigates novel approaches to
delivering care for Indo-Asian diabetic patients. There are links to several NHS partners,
clinical and academic centres worldwide. A Centre of Excellence in Diabetes Research and
Education (WISDEM) has been established within the new hospital.

Cardiovascular Medicine and Epidemiology
The main research interests of CSRI in this field are the prevention, detection and
management of hypertension and its complications, and the epidemiology of cardiovascular
disease and stroke. The relationships between nutrition, metabolic abnormalities and
cardiovascular risk, including risk assessment in ethnic minorities, both in developed and
developing countries are being studied by the group led by Prof F P Cappuccio, with
particular emphasis on the role of inflammation and immunity in cardiovascular disease in
entire populations. Work leading to the identification of novel biochemical markers for
cardiovascular risk are being led by Dr M Miller, as part of large studies (e.g. Whitehall II,
Olivetti) Epidemiological studies are performed locally within the Midlands, and internationally
International cardiovascular health studies on the role of high salt- intake in raised blood
pressure in rural communities are being performed on cohorts in Western Africa. The
relationship between alcohol intake and liver disease is also being investigated in population-
based studies (Dr S Stranges). There are close interactions with epidemiological and public
health research performed within the Health Sciences Research Institute (HSRI) of the

Prof Cappuccio‟s group also has a major interest in the interaction between sleep and the
development of obesity and cardiovascular disease, particularly as they impinge on other
metabolically active factors such as sub-clinical chronic inflammation.

Microvascular research (led by Prof D R Singer) is exploring why patients with high blood
pressure and other cardiovascular risk factors have impaired function of small arteries and
fewer capillaries than normal (rarefaction). Recent imaging and protein- characterization
studies have shown how oxidant stress can prevent normal activity. Protein-carbohydrate and
protein-protein interactions that underpin immune function and virus-host interactions as they
relate to the oligosaccharide binding properties of specific endothelial cell surface proteins
are studied by Dr D Mitchell (RCUK Fellow).

Molecular Medicine and Endocrinology
The major interests in endocrinology within the CSRI are centred on the structure-function
relationships of hormone receptors, and mechanisms of signal transduction. In particular the
central nervous actions of insulin and leptin, and their effects on cognitive function are being
studied by Prof H Lehnert who also has a major interest in endocrine tumours, and
particularly phaeocromocytoma. The role of central and peripheral orexin, adiponectin and
ghrelin action in body weight regulation and insulin sensitivity are studied by the group led by
Dr H Randeva. The signal transduction mechanisms, and particularly the activation and
subcellular localisation of the protein kinases, involved in the action of corticotropin releasing
hormone (CRH) are studied by Prof D Grammatopoulos. These studies have strong links
with those being performed on the regulation of G-protein signalling as part of the
Reproductive Health programme.

Clinical studies are being performed into the pathogenesis of endocrine tumours and the
relevance of the expression of the telomeric complex as an indicator of malignancy
particularly of endocrine tumours.

Reproductive Health
Within this programme, which is under the overall leadership of Prof S Thornton, two major
lines of research are followed; Obstetrics and Reproductive Medicine.

Obstetrics research at CSRI predominantly aims at understanding the fundamental principles
controlling myometrial (uterine) contractility and the associated pathologies of pre-term labour,
pre-eclampsia and dystocia. Members of the preterm labour group have research interests
that range from basic science through translational medicine to clinical trials. Micro-genomic
strategies are used to correlate differential patterns of gene expression in different cells and
regions of the uterus with myometrial physiology, with particular reference to the spatial
expression of proteins within myocytes. Using cells isolated by laser-capture micro dissection
(LCM) from frozen sections of human myometrium followed by single-cell PCR analysis, the
heterogeneity of the uterine cell population with respect to the expression of the oxytocin
receptor and different ion channels and transporters within individual cell-types have been
studied. These experimental data are used to generate mathematical models of the contractile
function of the uterus under conditions associated to pre-term labour (Prof S Thornton and Dr
A Blanks, RCUK Fellow). The role of voltage-gated L-type Ca2+ channels in uterine contractility
in human uterus is being delineated by Dr A Shmygol who is also interested in the physiology
of uterine interstitial cells. The roles of oxytocin and prostaglandins in the timing of parturition
and cervical ripening are being studied by Dr D Slater and Dr S Astle.

The interactions with the Molecular Medicine and Endocrinology group focus on the study of
the role of Urocortin II (UCN II) and its interaction with type-2 corticotropin-releasing
hormone-receptor (CRH-R2) in myometrial contractility by Prof D Grammatopoulos. In
addition, using a yeast model system to study G-protein coupled receptors (as exemplified by
CRH) combined with mathematical modelling, Dr G Ladds is studying dimerisation of G-
protein-coupled receptors (GPCRs), and the specificity of GPCR-G and G-RGS
interactions.      The pathogenesis of placental dysfunction, with reference to intrauterine
growth retardation (IUGR) and pre-eclampsia, is studied by the group of Dr M Vatish, using
human tissue, cell lines and a transgenic mouse model of pre-eclampsia. The work aims to
identify GPCRs involved in determining placental vascularisation, and the relationship with
foetal nutrition and maternal hypertension.

Clinical studies include on the use of Electromyography (EMG) in the diagnosis and
management of term and preterm labour, and the role of drugs to prevent premature delivery.
This has included the setting up by Prof S Thornton of the national Preterm Labour Network,
which includes most UK teaching hospitals, and assesses clinical trial proposals for
submission to major national funding bodies including the MRC. Other clinical trials are being
conducted with the pharmaceutical industry.
Reproductive Medicine
This research investigates mechanisms underlying human infertility. There is an extensive
programme of work aimed at understanding egg- and sperm-formation, fertilisation and
embryo development (Dr G Hartshorne and Dr S Keay). In particular, a programme of work
aimed at identifying competent embryos is being pursued with the aim of establishing
procedures that will allow fewer embryos to be transferred during IVF treatment, so
minimising the possibility of multiple pregnancies. A particular area of investigation involves
quantifying the control of male- and female-derived genes at fertilisation which is important in
understanding genetic diseases arising from „imprinting disorders‟ that may possibly arise
from abnormal sperm- or egg-formation. Other research into reproductive genetics is aimed
at understanding the impairment of fertility and poor pregnancy-outcomes. For example, an
EC-funded network of 52 research groups, co-ordinated from Warwick, is developing
methods for detecting chromosome disorders, such as Downs Syndrome, using blood from
mothers in early pregnancy.

Trauma and Orthopaedics
Prof D Griffin leads a multidisciplinary orthopaedic team at CSRI, comprising scientists and
surgeons who collaborate with statisticians, methodologists, health economists and trial
managers. They have particular expertise in the design of large national and international
studies that investigate the clinical effectiveness of particular interventions e.g. in the
treatment of heel fracture and Achilles tendon rupture. The development of new orthopaedic
technologies is coupled with clinical and cost-effectiveness assessment to ensure health- and
socio-economic gains from these new developments.

Professors at Warwick Medical School

Clinical Professors
The current clinical professors at the University of Warwick are Yvonne Carter [General
Practice & Dean of WMS], Martin Underwood [Primary Care Research & Vice-Dean of WMS],
Neil Johnson [Medical Education & Associate Dean (Teaching)], Sudhesh Kumar [Medicine,
Diabetes and Metabolism & Associate Dean (External Affairs)], Steve Thornton [Obstetrics &
Associate Dean (Clinical Research)], Sarah Stewart-Brown [Public Health & Director of the
Health Sciences Research Institute], Jill Thistlethwaite [Clinical Education and Research &
Director of ICE], Francesco Cappuccio [Cardiovascular Medicine and Epidemiology], Antonio
Ceriello [Diabetes & Endocrinology] Matthew Cooke [Emergency Medicine & Clinical Systems
Improvement], Jeremy Dale [Primary Care], Bill Fulford [Philosophy & Mental Health], Fang
Gao-Smith [Anaesthesia Critical Care & Pain], Damian Griffin [Trauma & Orthopaedic
Surgery], Simon Murch [Paediatrics & Child Health], Chris Poole [Oncology], Donald Singer
[Clinical Pharmacology], Swaran Singh [Social and Community Psychiatry] and Scott Weich

Non-Clinical Professors
The non-clinical professors are John Davey [Cell Biology, Associate Dean (Biomedical
Research) & Director of CSRI], Peter Abrahams [Anatomy], Jane Barlow (Public Health in the
Early Years], Colin Blakemore, Janet Dunn [Cancer Clinical Trials], Martin Feelisch
[Experimental Medicine], Dimitris Grammatopoulos [Molecular Medicine], Geraldine
Hartshorne [Professorial Fellow], Sallie Lamb [Rehabilitation & Clinical Trials], David
Spanswick [Molecular Neurosciences], Peter Spurgeon [Health Services Management], Justin
St. John [Reproductive Biology], Nigel Stallard [Medical Statistics], Ala Szczepura [Health
Services Research], Paul Thornalley [Systems Biology], Margaret Thorogood [Epidemiology],
and Victor Zammit [Molecular Biochemistry].

The Trust

The Trust was formed as a Third Wave Trust in April 1993 by the merger of the former
Walsgrave Hospital NHS Trust and Coventry and Warwickshire Hospital.

On 1 April 1998, Walsgrave Hospitals NHS Trust merged with Rugby NHS Trust,
incorporating the Hospital of St Cross. These hospitals provide a comprehensive range of
complementary services to the population of Coventry, Warwickshire and beyond, main
purchasers being Coventry and Warwickshire Strategic Health Authorities.

On 1st November 2000 the Trust was renamed the “University Hospitals Coventry and
Warwickshire NHS Trust” in recognition of its‟ status as the principle Acute Trust for the newly
formed Warwick Medical School.

In July 2006, the Trust occupied a new acute hospital. This state of the art facility has enabled
the merger of the Old Coventry and Warwickshire hospital and the departments already on
the Walsgrave site into one building.

The New Coventry Hospital

More than £395 million has been invested in a brand new hospital for the people of Coventry
and Warwickshire. The new hospital, one of the biggest UK Hospital complexes to be built,
includes state of the art medical technology coupled with modern, purpose built facilities for
patients – all on a single site. It provides a long awaited replacement for both the Walsgrave
and the Coventry and Warwickshire Hospitals and ensures that the local population continues
to receive high quality services into the 21 century.

The Hospital complex has a state of the art Clinical Sciences Building which opened in
November 2003 and houses the new Medical Education and Training Centres which include:

Library areas                                2 syndicate rooms
Lecture Theatre                              8 Skills training rooms
14 Seminar rooms                             Research laboratories
3 IT training rooms                          IT, catering and office infrastructure
Clinical Skills room

There are also a number of close-to-patient teaching areas in the main hospital (average 1
per ward or outpatient clinic) where students can be given practical training in proximity to

The general hospital building was completed in 2006. It has brought together services
previously provided by Walsgrave and Coventry & Warwickshire Hospitals and represents the
latest in high tech investigation, diagnostic and treatment equipment. This has sped up the
diagnosis and treatment of patients, providing a faster and more effective service.

This new state-of-the-art building will ensure that our patients receive care that measures up
against not just the best in this country but the best in Europe and North America.

The Trust occupies 75 acres in the North East of Coventry, some four miles from the city
centre and one mile from junction 2 of the M6 motorway. The catchment population is over
350,000 and in the sub-regional specialities the Trust serves a population of over 800,000.
The Trust is managerially divided into four areas:
    Medical, Women and Children‟s Division
    Surgical Division
    Combined specialities services
    Acute care, critical care and theatre

As one of the largest organisations of its type in the UK the Trust has 1,337 beds, around
6,500 staff with a budget of over £280 million a year.

The Trust operates from three sites:

Walsgrave Hospital, Coventry
The Hospital of St. Cross, Rugby
Wayside House, Bedworth

The Trust achieved 3 star rating following the last Commission for Health improvement visit.

The Trust has achieved green rating for cleanliness and food quality in the PEAT inspection.

Department of Obstetrics and Gynaecology

The Department of Obstetrics & Gynaecology falls under the management of the Division of
Medicine, one of five management divisions within the Trust. The Department of Obstetrics &
Gynaecology is located within the West Wing in the new teaching hospital and includes
regional Neonatal ICU, SCBU, Gynaecology, Obstetrics, Emergency Assessment Unit,
Colposcopy & Hysteroscopy suite, Fetal Well Being Unit and The Centre for Reproductive
Medicine. The department hosts 5000 births, 2500 gynaecological emergencies and 4000
elective gynaecology cases annually.

Sub specialist services are currently provided in the maternal and fetal aspects of Feto
Maternal Medicine. Ultrasound services are well developed within the department in both
obstetrics and gynaecology. Diagnosis in gynaecological cancer is supported by a consultant
with expertise in gynaecological ultrasound, weekly post-menopausal bleeding and
hysteroscopy clinics and a nurse specialist in ultrasound attached to the gynaecology
oncology clinics. The Centre for Reproductive Medicine hosts a large assisted conception
programme, including IVF and ICSI and monthly reproductive endocrinology and recurrent
miscarriage clinics. Urogynaecology is provided by two consultants.

The Obstetrics and Gynaecology Department includes:


           24 gynaecology beds
           4 bed emergency assessment unit
           Dedicated gynaecology operating theatres adjacent to the obstetric theatre suite
            but forming part of the main operating department
           Access to the main surgical day unit
           Gynaecology clinic and gynaecology ultrasound (part of the out patient facility
            based in the West Wing)
           Out patient hysteroscopy and colposcopy suite
           Early pregnancy assessment clinic - held daily
           Centre for Reproductive Medicine - providing a fully comprehensive sub-fertility

            68 obstetric beds
            Labour ward
            Twin obstetric operating theatres
            Fetal Well Being unit providing out patient fetal monitoring for high risk
            Obstetric admission unit
            Antenatal clinic and obstetric ultrasound suite

Departmental Staffing Structure

The Women & Children‟s Directorate is managed by:

Clinical Director                                      Manu Vatish
General Manager                                        Ann Littley
Head of Midwifery                                      Carmel McCalmont
Gynaecology Modern Matron                              Claire Bonniger
Obstetrics Modern Matron                               Bernie Donohue, Isobel
                                                       McDermott, Ann O’Reilly

The Department of Obstetrics & Gynaecology meets monthly at its divisional meeting. The
division determines clinical policy, advises the management team and is informed by the
Clinical Governance Committee. Division reports to the Medicine Division Management Team
through the clinical director.

Consultant staff

       Name                                      Special Interest

       Mr L Anwanyu                           Menstrual disorders and out patient
       Mr K A Cietak                          Gynaecological Imaging, “One stop”
       Dr L Farrall                           Feto-Maternal- Medicine and Imaging
       Mrs G Goswami                          Urogynaecology
       Mr R Kennedy (Clinical Director)       Reproductive Medicine, Minimal Access
       Mr S Keay (RCOG Postgraduate Tutor)    Senior Lecturer – Reproductive Medicine
       Mr T Parsons                           Senior Lecturer – Community Sexual and
                                              Reproductive Health and Menopause
       Mr M Vatish                            Senior Lecturer – Obstetrics
       Mr M Dunderdale (Chairman of Division) Oncology
       Mr L J Sant Cassia (Lead Clinician Oncology
       Professor S Thornton                   Obstetrics / Feto-Maternal medicine
       Mr L Wood (Lead Clinician Labour ward) Obstetrics / Medical education
       Dr Sasha Rajendran (Undergraduate Medical education / Feto-Maternal medicine
       Training Lead)                         and Imaging
       Mr Ram Athavale                        Oncology
       Dr Margaret Spiteri                    Urogynaecology
       Dr N Engineer                          Fetal-Maternal Medicine
Recruitment of Ex-Offenders Policy
(Developed in line with the CRB Disclosure information pack, part DIP011)

This Policy applies to all staff recruitment at the University of Warwick.

As an organisation using the Criminal Records Bureau (CRB) Disclosure service to assess applicants‟
suitability for positions of trust, the University of Warwick complies fully with the CRB Code of Practice
and undertakes to treat all applicants for positions fairly. It undertakes not to discriminate unfairly
against any subject of a Disclosure on the basis of a conviction or other information revealed.

The University of Warwick is committed to the fair treatment of its staff, potential staff or users of its
services, regardless of race, gender, religion, sexual orientation, responsibilities for dependants, age,
physical/mental disability or offending background.

Our written policy on the recruitment of ex-offenders is made available to all applicants at the outset of
the recruitment process.

We actively promote equality of opportunity for all with the right mix of talent, skills and potential and
welcome applications from a wide range of candidates, including those with criminal records. We select
all candidates for interview based on their skills, qualifications and experience.

A Disclosure is only requested after a thorough risk assessment has indicated that one is both
proportionate and relevant to the position concerned. For those positions where a Disclosure is
required, all application forms, job adverts and recruitment briefs will contain a statement that a
Disclosure will be requested in the event of the individual being offered the position.

Where a Disclosure is to form part of the recruitment process, we encourage all applicants called for
interview to provide details of their criminal record at an early stage in the application process. We
request that this information is sent under separate, confidential cover, to a designated person within
the University of Warwick and we guarantee that this information will only be seen by those who need to
see it as part of the recruitment process.

Unless the nature of the position allows the University of Warwick to ask questions about the applicants
entire criminal record, we only ask about „unspent‟ convictions as defined in the Rehabilitation of
Offenders Act 1974.

We ensure that all appropriate staff in Personnel Services at the University of Warwick who are involved
in the recruitment process have been suitably trained to identify and assess the relevance and
circumstances of offences. We also ensure that they have received appropriate guidance in the
relevant legislation relating to the employment of ex-offenders, e.g. the Rehabilitation of Offenders Act
1974. Line managers are advised who to approach for support on these issues.

At interview, or in a separate discussion, we ensure that an open and measured discussion takes place
on the subject of any offences or other matter that might be relevant to the position. Failure on the part
of the applicant to reveal information that is directly relevant to the position sought could lead to
withdrawal of an offer of employment.

We make every subject of a CRB Disclosure aware of the existence of the CRB Code of Practice and
make a copy available on request.

We undertake to discuss any matter revealed in a Disclosure with the person seeking the position
before withdrawing a conditional offer of employment.

We do not accept Disclosures transferred from other organisations and do not supply Disclosures
requested by us to any external organisations.

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