免疫反應的基本概念
Immune components
Immune cells Soluble mediators Immune organs Principles of innate and adaptive immunity
未打麻疹疫苗 引爆群聚感染
2009.02.18
2008/11
Population immunity
2009/1自大陸返台 十一個月女嬰住院
聯合報
Two surfaces
Self/non-self recognition
Antigen (Ag)
Immunity
The state of protection from infectious disease
Immune cells (Leukocytes)
Immune cells (Leukocytes)
Bone marrow
Antibody
CD4 CD8
Cytotoxicity Phagocytes
Dendritic cells (DC)
Granulocytes
macrophages
Phagocytosis 吞噬作用
Degranulation
Basophils Mast cells
Clusters of differentiation (CD)
Morphology Function Cell surface marker 表11-4,5
Immune activation
Ag
Activated immune cells
Cell activation
Ag
Soluble mediators Cytokines (IL), chemokines, ….
細胞激素 趨化激素
Mutial stimulation
表11-1
免疫細胞的活性功能與細胞表面的分子有關
免疫細胞具獨特性但無法單獨行動
Fig 2-7
From innate to Adaptive immunity
Interdependence
交互作用
Ag tracing is based on Ag location
Ag
Innate
Adaptive
Extracellular
Intracellular (Altered self)
Phagocytes
NK
B cells
Tc cells
Interdependence
Adaptive immunity
Humoral immunity
CD4 Th
B cells CD8T (Tc)
Cell-mediated immunity (CMI)
Lymph node distribution in the body
Macrophage
Phagocytosis Antigen presenting cells (APC)
Major histocompatibility complex (MHC)
Antibody
Adaptive immunity APC
Innate immunity
Principles of innate and adaptive immunity
Immune cells (Leukocytes)
Cell function
CD4 CD8
Dendritic cells (DC)
macrophages
Ag tracing is based on Ag location
Ag
Innate
Adaptive
Extracellular
Intracellular (Altered self)
Phagocytes
NK
B cells
Tc cells
Interdependence