NA MIC National Alliance for Medical Image Computing http na mic org Core 3 1 Dartmouth Activities Andrew J Saykin Psy D ABPP CN by oyy20534

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									                     NA-MIC
National Alliance for Medical Image Computing
                http://na-mic.org




Core 3.1 - Dartmouth Activities

       Andrew J. Saykin, Psy.D., ABPP-CN
              John D. West, M.S.
             Robert M. Roth, Ph.D.



            Brain Imaging Laboratory
        Dartmouth Medical School / DHMC
                                                Overview



      Volumetric ROI studies
      Diffusion tensor imaging
        ROI analyses
        Tractography
      Functional magnetic resonance imaging
      Planned applications
      Related work
      Current Collaborations



National Alliance for Medical Image Computing              http://na-mic.org
                                ROI Volumetric Studies


                  Manual Tracing and 3D Modeling of
                          ROIs using Slicer
     ROIs:
        Hippocampus
        Amygdala
        Entorhinal cortex
        Caudate nucleus
        Putamen
        Nucleus accumbens
        Thalamus
        Fornix
        Mammillary bodies
National Alliance for Medical Image Computing            http://na-mic.org
                                ROI Volumetric Studies


                     Illustration of 2D Traces and 3D Models of ROIs




National Alliance for Medical Image Computing                          http://na-mic.org
                              Diffusion Tensor Imaging


      FA in Uncinate Fasciculus ROI in Schizophrenia
                       using Slicer




                                                     Based on Kubicki et al., 2002

National Alliance for Medical Image Computing                       http://na-mic.org
                               Diffusion Tensor Imaging


       Integration of Corpus Callosum Subregion ROIs with Tractography
                                                      Healthy Control




                                                  Patient with Schizophrenia



          C1   -   rostrum and genu
          C2   -   anterior truncus
          C3   -   middle truncus
          C4   -   posterior truncus
          C5   -   isthmus and splenium
                   [Wang et al. 2005]

National Alliance for Medical Image Computing                           http://na-mic.org
                                        Functional MRI


       Cognitive Task Development and Validation:
          Probing Frontal-Temporal Circuitry

     Primary Tasks:
             Working memory
             Episodic memory
             Semantic memory

     Secondary Tasks (other Circuitry)
             Self-reflection
             Reward
             Planning

National Alliance for Medical Image Computing            http://na-mic.org
                                         Functional MRI


       Prospective Data Collection on 1.5T Magnet:
            Interim Analysis of Patients with
               Schizophrenia and Controls
                               Controls             Patients      p
                                 (n=8)               (n=13)
Age (yrs.)                     30.8 (7.1)           36.4 (10.3)    NS
Educ (yrs.)*                   16.9 (2.4)           14.6 (1.9)    .05
Sex (M,F)                         3, 5                 9, 3        NS
WRAT Reading                   111.5 (4.7)         105.0 (10.5)    NS
CVLT-II Total 1-5               58.4 (6.4)          38.6 (10.4)   .001


* matched for parental SES


 National Alliance for Medical Image Computing                    http://na-mic.org
                                        Functional MRI
                                 n-Back Working Memory Task




National Alliance for Medical Image Computing                 http://na-mic.org
                Functional MRI – Behavioral Performance



                                                Interim analysis




National Alliance for Medical Image Computing               http://na-mic.org
                                           Functional MRI


                       FMRI Activation During 3-Back in Schizophrenia

                                                   Simple Effects




                      Controls                                      Patients
                       N=8                                          N = 12
Interim analysis                                                               p = .01

   National Alliance for Medical Image Computing                               http://na-mic.org
                                           Functional MRI


                       FMRI Activation During 3-Back in Schizophrenia

                 Controls > Patients                        Patients > Controls




Interim analysis                                                           p = .01

   National Alliance for Medical Image Computing                            http://na-mic.org
                                        Functional MRI
                Verbal Encoding/Retrieval Episodic Memory Task




National Alliance for Medical Image Computing               http://na-mic.org
                Functional MRI – Behavioral Performance
                   Verbal Encoding/Retrieval Episodic Memory Task




Interim analysis

   National Alliance for Medical Image Computing               http://na-mic.org
                Functional MRI – Behavioral Performance
                   Verbal Encoding/Retrieval Episodic Memory Task




Interim analysis

   National Alliance for Medical Image Computing               http://na-mic.org
                                           Functional MRI
                   Verbal Encoding/Retrieval Episodic Memory Task
              FMRI Activation During Continuous Auditory-Verbal Memory
               (new > old word contrast) in Patients with Schizophrenia




                                                   Patients
Interim analysis                                    N=7           p = .01

   National Alliance for Medical Image Computing                  http://na-mic.org
                           Collaborations and Progress


 Shape Analysis with UNC Group: Martin Styner, Guido Gerig
 Hippocampal Shape - Dartmouth Data: SPHARM

      Overall Mean                               Left Mean                         Right Mean




 Skeleton-based subdivision




                                                 http://www.na-mic.org/Wiki/index.php/Progress_Report:Shape_Analysis
 National Alliance for Medical Image Computing                                                    http://na-mic.org
                           Collaborations and Progress


 fMRI in Slicer – fMRIEngine - Wendy Plesniak and Haiying Liu
      Met Dec. 14th, 2005 to discuss progress and future
     improvements to be made
      Have supplied motor data from two controls to test results
     from module and compare with results from SPM2
 fMRI tasks – Brigham group
      Porting of our tasks to BWH
      Meeting with Marek Kubicki on Dec. 20th, 2005 to
     demonstrate our tasks and how we utilize them
 Training session at BWH
      Tara McHugh visited to get in depth training in Slicer for
     tracing structures – Dec. 1st, 2005
 National Alliance for Medical Image Computing              http://na-mic.org
                           Collaborations and Progress


 Working with Steve Pieper to test 64-bit Linux version of Slicer
 Worked with Steve Pieper, Gordon Kindlmann, Xiaodong Tao,
and Josh Snyder to convert Dartmouth DTI data to nrrd format and
solve lingering orientation issues
 DTI Path of Interest – MGH – David Tuch and Josh Snyder
      Dartmouth request for tools to help relate DTI fiber tract
     pathways to connections in fMRI identified circuits
      Collaboration to implement DTI Path of Interest Program at
     Dartmouth site
      Successful initial results on NAMIC01 healthy control by both
     Josh Snyder at MGH and John West at Dartmouth
      Plans: integrate functional ROIs derived from fMRI tasks
 National Alliance for Medical Image Computing              http://na-mic.org
                     DTI Path of Interest – Initial Results


Collaboration with David Tuch & Josh Snyder (MGH)

Description – program finds the optimal path between two or
more ROIs using probability statistics

 Implementation
     C-code, Matlab and FSL scripts to generate optimal path
     Slicer for visualization and tracing of input ROIs
     Full implementation in Slicer as module is a future project

 Initial results from NAMIC01 healthy control
  National Alliance for Medical Image Computing               http://na-mic.org
                   DTI Path of Interest – Initial Results


                       Hippocampal ROI to Ventral Prefrontal ROI
                                Uncinate Fasciculus




National Alliance for Medical Image Computing                      http://na-mic.org
                   DTI Path of Interest – Initial Results


           Receptive Speech Area ROI to Expressive Speech Area ROI
                              Arcuate Fasciculus




National Alliance for Medical Image Computing                    http://na-mic.org
                   DTI Path of Interest – Initial Results

                      Hippo ROI to Expressive Speech Area ROI
                      Using Receptive Speech Area ROI as Guide
                                 Arcuate Fasciculus




National Alliance for Medical Image Computing                    http://na-mic.org
                Planned Applications & Developments


  Integration of fMRI and DTI data, including
  tractography (see tool “wish list”)

  Effective and functional connectivity during cognitive
  tasks (see tool “wish list”)

  Examine structural (ROI, DTI) and functional (fMRI)
  correlates of symptoms and cognition

  Expand use of methods to other populations
     bipolar disorder, OCD, MCI/AD, MS, TBI,
    epilepsy, other disorders
National Alliance for Medical Image Computing         http://na-mic.org
            Neuroimaging Research Center 3T Magnet




National Alliance for Medical Image Computing    http://na-mic.org
            Neuroimaging Research Center 3T Magnet




National Alliance for Medical Image Computing    http://na-mic.org
             Brain Imaging Laboratory: People

   FACULTY PIs (Psychiatry):                       BIL COORDINATOR
   •  Laura A. Flashman, Ph.D.                     •   Heather Pixley, B.A.
   •  Alan I. Green, M.D.
   •  Thomas W. McAllister, M.D.                   IMAGE ANALYSTS & SYSTEMS ADMIN:
   •  Brenna C. McDonald, Psy.D.                   •  John MacDonald, M.A.
   •  Robert M. Roth, Ph.D.                        •  Tara McHugh, M.A.
   •  Andrew J. Saykin, Psy.D.                     •  Paul Wang, B.A.
   •  Heather A. Wishart, Ph.D.                    •  John West, M.S.

   POST-DOCTORAL FELLOWS:                          STUDY COORDINATORS:
   •  Howard Cleavinger, Ph.D. (Epilepsy)          •  Mary Hynes, RN (TBI)
   •  Ellen Crouse, Ph.D. (MCI, chemotherapy)      •  Ariel Rosen, B.A. (MS)
   •  Nancy Koven, Ph.D. (Schizophrenia)
   •  Nadia Paré Ph.D. (MCI, ADNI)                 NEUROSCIENCE TECHNICIANS:
   •  Jo Cara Pendergrass, Ph.D. (Schizophrenia)   •  Carrie Kruck, B.A. (chemotherapy)
                                                   •  Margaret Nordstrom, B.A. (MCI)
   KEY TECHNICAL COLLABORATORS:
   •  Konstantinos Arfanakis, Ph.D. (DTI; IIT)     RESEARCH MRI TECHNOLOGISTS:
   •  Fillia Makedon , Ph.D. (Computer Science)    •  Jorge A. Forero
   •  James C. Ford, Ph.D. (Computer Science)      •  Alice E. Davison
   •  Li Shen, Ph.D. (CS, UMASS-Dartmouth)
   •  Jason Moore, Ph.D. (Comp Genetics)


National Alliance for Medical Image Computing                                  http://na-mic.org
                  Dartmouth Brain Imaging Laboratory




                                       December, 2005




National Alliance for Medical Image Computing           http://na-mic.org

								
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