The Beneficial Effects of Alkaline-Rich, Antioxidant Water Most of the research in this area is conducted in Asia and is translated into English Water: Nature‟s Elixir for Healthy Aging and Brain Health By Bruce D. Curtis, MA and Marianne L. Curtis, CAMT, CFT* "Every function inside the body is regulated by and depends on water. Water must be available to carry vital elements, [hydrogen], oxygen, hormones, and chemical massages to all parts of the body. Without sufficient [hydrogen rich] water to wet all parts equally, some more remote parts of the body will not receive the vital elements that water supplies. Without sufficient [hydrogen rich]water to constantly wet all parts, your body's drought-imanagement system kicks into action. The histamine-directed chemical messenger systems are activated to arrange a new, low quota ofwater for the drought-stricken area. When histamine and its subordinate "drought managers" come across pain-sensing nerves, they cause pain. This is why dehydration produces pain as its first alarm signal. If the dehydration persists and is not corrected naturally with water, it becomes symptom-producing and, in time, develops into a disease condition." -From Your Body‟s Many Cries for Water by F. Batmanghelidj, MD Background The oxidative theory of aging is so well established in the health sciences that it has become an accepted axiom. In fact, we trace its origin in 1954 to Dr. Denham Harman of the University of Nebraska who is recognized as the father of the Free Radical Theory of Aging (FRTA). This theory and subsequent clinical research has led to an explosive growth in specialized functional food products that tout their anti-oxidant qualities, to such an extent that one can even see the claim of anti-oxidant action on cans of Cherry 7-Up! None of the popular claims can diminish by one iota the foundational significance of anti-oxidant action for longevity. More careful examination of biochemical processes, however, reveals a much more complex chain of reactions that leads to additional toxic by-products and oxidative radicals that result from the initial anti-oxidant reaction. Moreover, none of the miracle anti-oxidant foods seems to be presented with the understanding that achieving the desired effects of the food is entirely dependent upon a satisfactory intake of water. To re-iterate Dr. Batmanghelidj‟s words: “Without [hydrogen rich] water, this solid matter is absolutely useless.” Thus, health care practitioners must always consider the primacy of water in the protocol they recommend, no matter what the ailment. To prescribe supplements without considering the means of their uptake is not precise. On this point Dr. Hidemitsu Hayashi, pioneer in the clinical study of healthy water, has commented, “Any dietary recipe cannot be a scientific one if property of water taken by the patients is not taken into consideration.” The Mitochondria Theory of Aging Related to the Free Radical Theory of Aging (FRTA) is the Mitochondrial Theory of Aging (MTA), again proposed by Denham Harman in 1972. Critical in the MTA is the contrast between nuclear DNA and mitochondrial DNA (mtDNA) which lies in the lack of histone protein protection and various enzyme repair systems in mtDNA that are common in nuclear DNA. This leaves mitochondrial DNA much more subject to the vagaries of oxidative radicals, especially the particularly damaging reactive oxygen species (ROS). The finer details of the entire mitochondrial aging process can be learned by reading The Mitochondrial Theory of Aging(2), and by studying proceedings of MiMAGE(3). How is water linked to aging in the Mitochondria? Since [hydrogen rich] water is governor of cellular activities, we need to better understand why and how intracellular water is so vital, but most importantly in the mitochondria. However, it is not a simple factor that is a consequence of aging, there is no formula for the loss of intracellular water. German studies indicate that the loss of water in the mitochondria is more significant than loss ofwater in the cytoplasm. Dr. David Wheeler, DC writes: “The mitochondria is the energy supplying component of all the cells in the body, which allows the infinite array of biochemical mechanisms to take place properly that start at the foundation of DNA cell replication as well as immune system function as the primary defense against all disease. Therefore, as a person ages based on an ever increasing dehydration of the mitochondria there is an increase in the aging process of the cells. This in turn causes a breakdown of all the glands, organs and systems of the body. The body as a whole becomes more and more subject to disease based on a loss of potential longevity. If there is a way to counter the dehydration of the mitochondria then the aging process will slow down and a person will live longer.” In fact, the production of ATP is dependent upon 2 functions of cell physiology: the Krebs cycle or “citric acid cycle,” and that of oxidative phosphorylation or electron transport chain (ETC). Lesser known, is that the reduction cycle depends upon hydrogen for the proton pump which supplies the protons to phosphorylate ADP into ATP. Without this hydrogen, ATP production would be impossible, and there would be no energy for any bodily function. This discovery led to the award of a Nobel Prize to Dr. Peter Mitchell in 1978 for his theory “Chemiosmosis.” To summarize, energy production for the entire human organism depends upon the flow of electrons and protons. The energy gradients formed by them are the essence of cellular biophysics. This confirms the fundamental insight of Dr. Albert Szent-Gyorgi in 1937, in which he observed: “Hydrogen is the only fuel the body recognizes.”5 Dr. Szent-Gyorgi also found that hydrogen pools in 6 major organ systems for ready availability for physiological needs. Specifically, he found that the order of hydrogen pooling is: Liver>Intestine>Kidney>Heart>Lung>Spleen. Liver tissues store the most hydrogen, while the spleen stores the least. This is interesting in view of the fact that the liver is your body‟s first line of defense and needs a supply of the most antioxidants in order to do its work of detoxification. To summarize, a primary task in supporting human longevity rests in helping protect the mitochondria from dehydration. But there is another energy factor at work with water that we must understand, and that is the quintessential role of hydrogen to maintain energy production which ensures proper cellular function, transcription accuracy for DNA, and thus proper cell replication. What‟s more, additional energy means more vitality. Further, as we will see in the next section, hydrogen aids detoxification by removing harmful metabolic waste and protects the cells by reducing damaging free radicals. Hydrogen, the most prevalent element in the universe and in our body, is therefore, the hidden key to our youthful health and vitality. Functional Water – Hydration plus Hydrogen Japanese research going back into the 1980‟s has augmented the understanding of the central role of water in supporting the human body‟s efforts to heal. Dr. Hidemitsu Hayashi began pioneering the use of electrolyzed water as a complementary treatment with health protocols. His clinical observations revealed incredible promise for functional water, particularly in the diversity of problems it addressed and conditions it ameliorated. In 1997 he published a paper on the role of reduced water as an anti-oxidant, with his colleague Dr. Sanetaka Shirahata.6 As one of the most quoted studies on water, this paper has been used by the water electrolyzer industry to promote sales of literally dozens of different designs of watermachines claiming to alkalize the body and heal all manner of disease. However, lost in the history of science was Dr. Shirahata‟s brilliant insight about which parameter of the water was effective in aiding the body. Was it the pH or was it something else? The body has very complex homeostatic mechanisms for maintaining its acidity and alkalinity of different parts. Cell membranes are very acidic and must remain so. Blood has a tiny window of pH 7.35 to 7.45, and whenever it moves outside that range, biochemical responses occur to bring it back, such as the release of carbonate to alkalize. What was Dr. Shirahata‟s conclusion about the real key to electrolyzed reduced water (ERW)? It was this: The reduction of proton in water to active hydrogen (atomic hydrogen, hydrogen radical) that can scavenge ROS is very easily caused by a weak current, compared to oxidation of hydroxyl ion to oxygen molecule. Activation of water by magnetic field, collision, minerals etc. will also producereduced water containing active hydrogen and/or hydrogen molecule. Several natural waters such as Hita Tenryosui water drawn from deep underground in Hita city in Japan, Nordenau water in Germany and Tlacote water in Mexico are known to alleviate various diseases. We have developed a sensitive method by which we can detect active hydrogen existing in reduced water, and have demonstrated that not only ERW but also natural reduced waters described above contain active hydrogen and scavenge ROS in cultured cells.7 Dr. Shirahata traveled to various parts of the world to investigate a number of healing waters and test them for hydrogen content. Finding them rich in molecular and atomic hydrogen, he decided to bring back samples to Dr. Hayashi in Japan. When he returned, he found that all of the hydrogen had escaped. What remained for him was the inescapable conclusion that it was the hydrogen in the reduced waters that was making the tap water into functional water. This realization became solidified in 2007 with the publication of another study by another group of scientists, this time published in Nature Medicine, showing that indeed the active hydrogen is able to scavenge reactive oxygen species (ROS) in cell cultures.8 Since 2007, researchers have done both in vivo and in vitro studies involving the use of hydrogen-rich water.9 Expanding research with reduced water has finally drawn the proper attention to the role of waterand has spawned a vast array of approaches to functional water and to the various parameters ofwater that might be significant. One prevalent example is the work with structured water. It has been hypothesized that smaller clusters of water molecules are critical for increased hydration, and some studies seem to back up this assertion. Nonetheless, it should be remembered thatwater is a food and needs to be metabolized. The aquaporins in the cell membrane are the small channels that admit water into the cell and they only allow one molecule of H2O at a time, so the work on clustered remains a bit obscure and still needs peer-reviewed studies to support its claims. The work with hydrogen-rich water does, on the other hand, find great support in the literature, and a rapidly growing body of evidence in peer-reviewed studies. Medicine of the Future – Hydrogen-rich Water An examination of the published studies on hydrogen-rich water and its effects reveals a promising development in the medical research field. Many of these studies are being done by scientists at a new center in Kawasaki, Japan. It is the Center of Molecular Hydrogen Medicine, Institute of Development and Aging Sciences at the Nippon Medical School. Hydrogen-rich water as a true functional water is so promising as to have inspired a whole new branch of medicine in Japan. This new approach to hydrogen medicine is an expression of the ever-expanding potential of integrative medicine. As the community of healers recovers deeper insights into the ancient wisdom of food as medicine and water as medicine, we will all see how the future and the past can come together. With the body being 70% water and the brain 85% water, how we ignore the primary importance of nature‟s elixir in our health and vitality? With the addition of active hydrogen, we will appropriate for our daily hygiene the power of some of nature‟s greatest healing springs. In that perhaps Dr. Hayashi‟s vision will come to pass: that one day hydrogen-rich water will become a simple and effective daily hygiene for youthful vitality, health and beauty. -------------------------------------------------------------------------- *Authors Bruce and Marianne Curtis have served on the editorial board of the Journal of Alternative and Complementary Medicine, and currently work with functional foods and functional water. Marianne has maintained a practice in oriental medicine for over 18 years. Bruce has written and lectured on the future of medicine. -------------------------------------------------------------------------------- References 1. Harman, D. (1972) "The biological clock: the mitochondria?" J Am Geriatr Soc 20: 145-47. 2. South, J. “ The Mitochondrial Theory of Aging” Can be seen at IAS Bulletin onhttp://www.antiaging- systems.com/extract/mitochondrial.htm 3. Scheckhuber C, 2005: Mitochondrial Dynamics in Cell Life and Death. Sci Aging Knowledge Environ. 2005 (47): p 36. 4. You can find a copy of Dr. Mitchell‟s Nobel address on the science page atwww.livingwaterusa.com. 5. Dr. Szent-Gyorgi‟s Nobel address is available on the science page at www.livingwaterusa.com. 6. Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, Gotoh M, Hayashi H, Otsubo K, Morisawa S, and Katakura Y. “Electrolyzed-Reduced Water Scavenges Active Oxygen Species and Protects DNA from Oxidative Damage”, Biochemical and Biophysical Research Comm., Vol. 234, No.1, May 8, 1997 7. Dr.Sanetaka Shirahata, Graduate school of Genetic Resources Technology, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. 8. “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals” Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S and Ohta S. Published in: Nature Medicine: Advance Online Publication, published on line May 7, 2007 Nature Publishing Group, http://www.nature.com/naturemedicine 9. Additional studies on the effect of hydrogen-rich water on diabetes, atherosclerosis, Parkinson‟s, and other diseases are cited on the science page at www.livingwaterusa.com. Sanetaka Shirahata - Graduate school of Genetic Resources Technology, Kyushu University, Japan It has long been established that reactive oxygen species (ROS) cause many types of damage to biomolecules and cellular structures, that, in turn result in the development of a variety of pathologic states such as diabetes, cancer and aging. Reduced water is defined as anti-oxidativewater produced by reduction of reactive oxygen species present in the water. Electrolyzed reducedwater (ERW) has been demonstrated to be hydrogen-rich water and can scavenge ROS in vitro (Shirahata et al., 1997). The reduction of proton in water to active hydrogen (atomic hydrogen, hydrogen radical) that can scavenge ROS is very easily caused by a weak current, compared to oxidation of hydroxyl ion to oxygen molecule. Activation of water by magnetic field, collision, minerals etc. will also producereduced water containing active hydrogen and/or hydrogen molecule. Several natural waters such as Hita Tenryosui water drawn from deep underground in Hita city in Japan, Nordenau water in Germany and Tlacote water in Mexico are known to alleviate various diseases. We have developed a sensitive method by which we can detect active hydrogen existing inreduced water, and have demonstrated that not only ERW but also natural reduced waters described above contain active hydrogen and scavenge ROS in cultured cells. ROS is known to cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in cultured cells.Reduced water scavenged intracellular ROS and stimulated glucose uptake in the presence or absence of insulin in both rat L6 skeletal muscle cells and mouse 3T3/L1 adipocytes. This insulin-like activity of reduced water was inhibited by wortmannin that is specific inhibitor of PI-3 kinase, a key molecule in insulin signaling pathways. Reduced water protected insulin-responsive cells from sugar toxicity and improved the damaged sugar tolerance of type 2 diabetes model mice, suggesting that reduced water may improve insulin-independent diabetes mellitus. Cancer cells are generally exposed to high oxidative stress.Reduced water cause impaired tumor phenotypes of human cancer cells, such as reduced growth rate, morphological changes, reduced colony formation ability in soft agar, passage number-dependent telomere shortening, reduced binding abilities of telomere binding proteins and suppressed metastasis. Reduced water suppressed the growth of cancer cells transplanted into mice, demonstrating their anti-cancer effects in vivo. Reduced water will be applicable to not only medicine but also food industries, agriculture, and manufacturing industries. Shirahata, S. et al.: Electrolyzed reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochem. Biophys. Res. Commun., 234, 269-274, 1997. JAACT 2000 FUKUOKA Symposium4 “Advanced Functional Foods and Water for Prevention of Disease” ------------------------------------------------------------------------ Hidemitsu HAYASHI, M.D., Water Institute,and Munenori KAWAMURA, M.D., Kyowa Medical Clinic, Electrolysis means redox reaction, reduction and oxidation (4). Electrolysis of water produces H2 gas at the cathode and O2 gas at the anode respectively (Fig.5). When the amount of atomic hydrogen becomes saturated, molecular hydrogen (H2 gas) is produced. We demonstrated in 1995 that reduced water contains increased molecular hydrogen by up to between 200 and 500 times, compared to that in original water before electrolysis (Tab.2). We can notice that reduced water contains both atomic and molecular hydrogen. Molecular hydrogen in reduced water is proven to be split to atomic hydrogen by Shirahata when it is brought into contact with the minerals in our body. And probably by hydrogenase, which should be inherited from our oldest ancestors, as suggested by Happe. The idea and means to reform water by electrolysis were developed in Japan about half a century ago. Such kinds of devices could be found nowhere but in Japan. The reason why should be found in the difference of water hardness. Japan is a country of soft water of (its hardness being around 50ppm), whereas hardness in London or Dallas is over 130ppm. Electrolysis can be said to be a principle of plating. Electrolysis of soft water brings little plating of cations such as calsium or magnesium on the surfaces of cathodes, whereas electrolysis of hard water brings significant plating on electrodes, which should have made it possible for hard water countries to develop such devices. The problem of plating in hard water electrolysis has been, however, solved by a new technology „Autochange-crossline system‟ developed several years ago in Japan, which was patented in the USA, Canada and Russia. Various types of researches by Shirahata have been made on the basis of these newly patented devices Clinical Impovements Obtained From The Intake Of Reduced Water Extracts from the Presentation At The Eight Annual International Symposium On man And His Environment in Health And Disease on February 24th 1990, at The Grand Kempinski Hotel, Dalls, Texas, USA by Dr. H. Hayashi, M.D. and Dr. M Kawamura, M.D ., on: THE CONCEPT OF PREHEPATIC MEDICINES Since the introduction of alkaline ionic water in our clinic in 1985, we have had the following interesting clinical experiences in the use of this type of water. By the use of alkaline ionic water for drinking and the preparation of meals for our in-patients, we have noticed :- Declines in blood sugar levels in diabetic patients. Improvements in peripheral circulation in diabetic gangrene. Declines in uric acid levels in patients with gout. Improvements in liver function exams in hepatic disorders. Improvements in gastroduodenal ulcer and prevention of their recurrences. Improvements in hypertension and hypotension. Improvements in allergic disorders such as asthma, urticaria, rhinites and atopic dermatitis. Improvements in persistent diarrhoea which occurred after gastrectomy. Quicker improvements in post operative bower paralysis. Improvements in serum bilirubin levels in new born babies. Being confirming clinical improvements, we have always observed changes of stools of the patients, with the colour of their feaces changing from black-brown colour to a brigher yellow-brown one, and the odour of their feaces becoming almost negligible. The number of patients complaining of constipation also decreased markedly. The change of stool findings strongly suggests that alkaline ionic water intake can decrease the production of putrefield or pathogenic metabolites. Devices to produce reduced water were introduced into our clinic in May 1985. Based on the clinical experiences obtained in the past 15 years, it can be said that introduction of electrolyzed-reduced water for drinking and cooking purpose for in-patients should be the very prerequisite in our daily medical practices. Any dietary recipe cannot be a scientific one if property of water is not taken by the patients is not taken into consideration. The Ministry of Health and Welfare in Japan announced in 1965 that the intake ofreduced water is effective for restoration of intestinal flora metabolism. Reduced Water (Ionized Water) for Prevention of Diseases Part paper delivered by Dr Shirahata to the Functional Water Symposium in Tokyo by Dr.Sanetaka Shirahata, Graduate school of Genetic Resources Technology, Kyushu University,6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-85 81, Japan. Diabetes ROS (free radicals) is known to cause reduction of glucose uptake (prevent glucose getting in to cells) by inhibiting the insulin-signaling pathway in cultured cells. Reduced water (ionized water) scavenged intracellular ROS andstimulated glucose uptake in the presence or absence of insulin (independently increased absorbtion of glucose in cells!) in both rat L6 skeletal muscle cells and mouse 3T3/L1 adipocytes. This insulin-like activity of reducedwater was inhibited by wortmannin that is specific inhibitor of PI-3 kinase, a key molecule in insulin signaling pathways. Reduced water protected insulin-responsive cells from sugar toxicity and improved the damaged sugar tolerance of type 2 diabetes model mice,suggesting that reduced water may improve insulin-independent diabetes mellitus. (may be effective in treating Type 1 diabetes) Cancer cells are generally exposed to high oxidative stress (free radicals). Reduced watercause impaired tumor phenotypes of human cancer cells, such as reduced growth rate, morphological changes, reduced colony formation ability in soft agar, passage number-dependent telomere shortening, reduced binding abilities of telomere binding proteins and suppressed metastasis. Reduced water suppressed the growth of cancer cells transplanted into mice and its ability to metastisize or spread to other organs), demonstrating their anticancer effects in vivo. Reduced water will be applicable to not only medicine but also food industries, agriculture, and manufacturing industries.
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