University of Oxford by liwenting


									                                   Job Description

Job Title:            Postdoctoral Research Scientist

Reference:            H3-11-011-AR

Salary Grade:         University Grade 7
                      £29,099 to £35,788 per annum

Location:             Old Road Campus Research Building, Oxford

Responsible to       Dr Anderson Ryan

Tenure:              The post is available for 3 years in the first instance

Role Summary         To investigate the impact of somatic gene mutations on the response
                     of lung cancer to novel and established therapies using in vivo models
                     of human disease


The Gray Institute for Radiation Oncology and Biology is an exciting initiative directed by
Professor Gillies McKenna, who as the Professor of Radiation Oncology and Biology at the
University of Oxford, has taken on the challenge to grow and strengthen academic research
and clinical work in the field of Radiation Oncology. This initiative in Oxford enhances the
collaborative support of the Medical Research Council (MRC) and Cancer Research UK
(CRUK) in this developing area of clinically based research.

The Gray Institute for Radiation Oncology and Biology is research-focused and clinically
relevant The Institute is housed in a state-of-the art facility which has the flexibility to
incorporate the future developments in radiobiology. The Gray Institute is the leading centre
for the identification an-d development of new translational targets, and provides education
and training in the field of radiation oncology and biology The Institute has led the
University’s successful bid for the CRUK & EPSRC Cancer Imaging Centre. As the National
Centre of Excellence in Radiation Oncology and Biology it combines the strengths of the
integrated multidisciplinary research teams and is developing new research groups and
activities including a clinical trials team.

The new purpose built facilities provide an exciting highly stimulating environment, being
situated in the Old Road Campus Research Building together with the Ludwig Institute for
Cancer Research, the Department of Clinical Pharmacology, the Jenner Institute and the
Structural Genomics Consortium.

Recent research has seen an explosion in our understanding of how certain somatic
mutations drive lung cancer growth and development in man. The aim of Dr Ryan’s Group is
to investigate these molecular changes in human lung cancer in order to understand how
they may affect outcomes to radiation therapy, chemotherapy and novel therapies with the
aim of improving clinical outcomes for patients with this devastating disease. A broad panel
of human lung cancer cell lines representing the molecular diversity of human disease is
being utilized to examine therapeutic combinations both in vitro in cell culture, and in in vivo
models using advanced imaging techniques. Blood and tumour samples from patients with
lung cancer are also being investigated to better understand how novel laboratory
observations and newly identified drug targets are relevant to clinical disease. It is
anticipated that this work will identify those patients who will get the greatest benefit from
novel targeted agents in combination with standard therapies, including radiotherapy, and the
optimal way to combine these agents in the clinic.


The post-holder will establish subcutaneous, orthotopic and autochthonous models of human
lung cancer and investigate the impact of somatic mutations on tumour development and
their relationships with human disease. The post holder will utilise these models to evaluate
and optimise tumour responses to therapeutic interventions, including radiotherapy,
chemotherapy and novel therapies. The successful candidate will be expected to
demonstrate initiative, both in experimental design and interpretation of data, and in
disseminating research findings.


      The post holder may be required to assist with the supervision of students and
       technical staff on a day-to-day basis.

Education and Training

      Keep up to date with developments in models of human cancer, targeted therapies in
       lung cancer and other topics related to the activities of the research group.

      Assistance in the education and training of other staff in laboratory procedures.


      Generate high quality data and reports suitable for publication and for submission in
       the context of grant proposals.

      Participate and contribute to group discussions and meetings including the
       presentation of own or published data.

      Present results in oral and written form, and discuss scientific findings at national and
       international meetings.

      To inform the Group Head and senior team members about progress or difficulties in
       research projects or services.

      Maintain confidentiality regarding research data when interacting with non-
       collaborating researchers.

      Take the lead in the preparation of manuscripts for peer-review and publication in
       scientific journals.

General responsibilities

      Act at all times in the interests of the Institute to ensure good laboratory practice.

      To be accountable for their own professional conduct within the Group.

      Ensure that work in the laboratory is conducted safely and, in particular, persons
       undertaking the work do so using appropriate safety procedures and in the dedicated

      Undertake duties as may be required from time to time that are commensurate with
       the grade and responsibilities of the post.

      Conduct him or herself with due regard to the University Equal Opportunities and
       Data Protection policies.

                                   Person Specification

Essential criteria

The successful applicant will be expected to meet the following criteria:

      A PhD/DPhil in Biology, Biochemistry, Molecular Biology or related Biomedical

      Practical experience of working with in vivo models of disease, preferably cancer
       although experience in other disease settings will also be considered.

      A current or recent UK Home Office Personal Licence (PIL).

      Expertise in standard tissue culture related techniques.

      Demonstrated ability to evaluate and interpret scientific data.

      Skills and confidence to communicate effectively in English to a broad range of
       audiences, both orally and in writing.

      An enthusiastic and organised self-starter with the ability to work under own initiative
       to drive the project forward.

Desirable criteria

      Familiarity with imaging or immunohistochemical techniques.

       Experience of analysing human tumour or xenograft tissue samples.
       Experience of successfully preparing and submitting scientific data for publication.

                                     Application Procedure

To apply please send a letter of application describing why you are applying for the position
and how you meet the advertised criteria together with your CV and the Personal Details
form (that is available from the website to:

Personnel Manager
Gray Institute for Radiation Oncology and Biology
University of Oxford
Old Road Campus Research Building
Off Roosevelt Drive
Oxford OX3 7DQ

or email it to:

The closing date for applications is Friday 15th April 2011 . Applications received after this
date will not be considered.

The University reserves the right to screen individuals for employment. Any such screening
would be discussed with you in advance of it taking place.

Please ensure that you quote the reference H3-11-011-AR in all correspondence.

                                          Pay and benefits

The salary offered for a full-time appointment to this job will be University grade 7, in the range
£29,099 - £35,788 per annum (with a discretionary range to £39,107 per annum), depending on
qualifications and experience. If you are appointed at a salary below the top of the substantive range,
your salary will automatically be increased each year until you have reached the top point. Increases
beyond this point may be available in certain cases. If appointed within the discretionary range, no
automatic incremental progression should be expected during this appointment. There is also an
annual ‘cost-of-living’ salary review, which normally takes place in summer each year. For a full-time
appointment, the annual holiday entitlement will be 38 days (including 8 public holidays). Full Time
hours of work are 37.5 hours per week. Pay and benefits (including holiday entitlement) for part-time
appointments are worked out on a ‘pro rata’ basis.

The appointment is subject to satisfactory completion of a one year probationary period, during which
the notice period will be one month on either side. Once the appointment has been confirmed, the
notice period will be three months on either side.

The post is pensionable and the post holder eligible for membership of the Universities
Superannuation Scheme (USS), a contributory scheme to which members pay 6.35 per cent of annual
salary. Subject to the Statement of Pensions Policy, which will be issued to the successful candidate,
the appointee will be deemed to be in membership of the above pension scheme until such time as
he/she gives notice in writing to exercise the right not to be a member of the scheme. Members of staff
are required to retire not later than the 30 September following their 65th birthday unless they can
demonstrate a vested interest (as defined in the University’s statutes) in retirement at 67. Employees
contributing to USS will also be automatically enrolled in the University’s Salary Exchange scheme for

pension contributions from three months after joining the pension scheme, unless they give notice in
writing to the Payroll Manager that they elect not to take advantage of this facility at least one month
before automatic enrolment. Details are available from the following website: The University also
offers a Stakeholder pension scheme which most employees may join either instead of, or in addition
to, the main scheme.

The University has a generous maternity leave scheme and also offers paternity leave to expectant
fathers and partners, and adoption leave. It offers subsidised nursery places, a childminding network,
a holiday playscheme, and tax and National Insurance savings schemes. For further information see

                        Equal opportunities at the University of Oxford

As an Equal Opportunity employer, we positively encourage applications from people of different
backgrounds. All our jobs are filled in line with our equal opportunities code of practice, which helps us
make sure that men and women, people of different religions or beliefs, ages, racial groups, and those
with disabilities are all treated fairly.

The policy and practice of the University of Oxford require that all staff are afforded equal opportunities
within employment. Entry into employment with the University and progression within employment will
be determined only by personal merit and the application of criteria which are related to the duties of
each particular post and the relevant salary structure. In all cases, ability to perform the job will be the
primary consideration. Subject to statutory provisions, no applicant or member of staff will be treated
less favourably than another because of his or her gender, marital or civil partnership status, sexual
orientation, religion or belief, racial group, age or disability.

If you have any questions about equal opportunities at the University of Oxford, please visit our web-
site at

                               Working for the University of Oxford

At the University of Oxford, we’re naturally very proud of our outstanding reputation for scholarship
and research. But we’re also proud to say that we’re one of the region’s biggest and best-established
employers, with a real diversity of staff helping to sustain our success - from lab. assistants, cleaners,
technicians and secretaries, to IT, finance and administrative professionals. Join us, and you can
expect to find yourself working in a friendly, open-minded atmosphere where your ideas will be
welcomed, with an interesting and satisfying job to do, and with plenty of opportunities to learn new
skills, or maybe even get some extra qualifications.

As well as pay and other benefits such as generous holidays and an excellent pension scheme, we
may be able to help you with:

       Training – We train our staff, both in the skills needed for starting the job, and to help them
        develop afterwards. If you don’t have all the skills we are looking for (e.g. computer
        packages), but you know that you are a quick learner, it’s worth asking if training might be
       Working hours – We may be able to be flexible about working patterns to help you combine
        work with responsibilities at home. Even for full-time jobs, we can often adjust starting and
        finishing times, or even sometimes consider term-time-only working: if this is important to you,
        let us know.
       Disability – If you have a disability, we have specialist staff who can help you to start and stay
        in work.
       Childcare – We have several subsidised nurseries for under-fives, a holiday play scheme,
        and tax and national insurance savings schemes. For further information see

       Parenting – As well as providing childcare facilities, we have generous maternity, paternity
        and adoption leave schemes to help new parents on our staff.
       Cultural and religious needs – We respect the cultural and religious lives of our staff. If you
        need time away from work, or special facilities, and can give plenty of notice for arrangements
        to be made, this will always be considered.
       Travel arrangements – We offer an interest-free season ticket loan scheme for bus or train
        season tickets. Annual passes for Oxford Bus Company routes are available at discounted
       Use of University facilities – All University staff can use the study facilities provided by
        University libraries and museums; join the University Club, a sports and social club which has
        its own bar, café, and reading room; and make use of the University Sports Complex and the
        Pulse fitness centre.
       Discounts – A number of discounts are available to University staff e.g. for insurance, holiday
        travel, and computer equipment.

The range of benefits is continuously reviewed and extended. For further information see


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