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					                   INTRODUCTION
It gives me a great pleasure to present you the 21Ist issue of the
College of Medicine Research Center‟s (CMRC) Report for the
years 2002-2004 (1422-1424). This report highlights the research
activities of the academic staff at the College of Medicine and
King Saud University Teaching Hospitals (KKUH and KAUH) in
the form of published scientific work as well as the ones
presented at the national and international symposia and
conferences. It also provides an outline of the research proposals
submitted to the Deanship of Scientific Research (King Saud
University) for financial support. This document not only highlights
the achievements made in various disciplines of basic and
applied medical sciences over the past two years but also reflects
the research interests and trends of our medical scientists. The
appearance of an appreciable amount of published work in the
national and international journals of high repute reflects the high
quality of research at our institution. I, therefore, would like to
extend my deepest sense of appreciation to all the researchers
who put the best of their efforts to get their scientific
achievements recognized and published worldwide.

One of the major objectives of CMRC is to encourage, facilitate
and promote basic and applied medical research in various
disciplines of medical sciences. Accordingly, CMRC approved
and funded 29 research proposals from various departments
during the last two years. In addition, CMRC is also providing
financial assistance to the postgraduate medical students. At
present, CMRC is supporting two postgraduate students from the
department of Physiology who are pursuing their doctoral (Ph.D)
degrees.



                                 7
In order to fulfill its commitment to promote and facilitate research
at this institution, CMRC has established a well organized team of
highly skilled and qualified personnels to provide best of their
services to the faculty and researchers at every level. At present,
CMRC is offering the following main services:

1. Literature Search and Medical Information

This unit provides the literature search services in the form of
abstracts from the National Library of Medicine (USA) based
Silver Platter MEDLINE Search (1966-2004) and full-text articles,
clinical updates, practice guidelines, drug information and patient
handouts from the MDConsult and PDxMD database (Elsevier
Publishers, USA). In addition, the articles which are not available
at the College of Medicine or King Saud University Central
Libraries are supplied from the King Faisal Specialist Hospital &
Research Centre Library or British library (UK) through the
generous cooperation of King Abdul Aziz City for Science and
Technology (KACST).

It is hoped that CMRC would be able to provide full-text articles
from most of the national and international journals in the near
future through further extension into its subscription. In order to
avoid frequent failure in the KSU internet service, CMRC is also
trying to set-up a high speed DSL connection to expedite the
downloading of the full-text articles.

2. Research Proposal Designing, Budgeting and Reviewing

Well-trained statisticians and research scientists at CMRC can
offer their services in designing a study, estimation of required
sample size, laying-out of the laboratory protocols, improving the
organization and management plan, and estimation of the




                                 8
required budget. CMRC can also render its expert opinion in the
purchasing of laboratory equipment or hiring of the technical staff.
Researchers can also submit their proposal to CMRC for
technical evaluation before actually submitting to the internal or
external funding authority.

3. Financial Support

With the generous cooperation of the Deanship of Scientific
Research at the King Saud University, CMRC provides full
financial support, covering the cost of materials, equipment,
research technician fees, and other requirements. Once approved
by the concerned departmental research committee, researchers
can submit their research proposals to the CMRC throughout the
year. The technical and academic evaluation of the proposal is
conducted by the CMRC nominated reviewers of high academic
repute whereas the ethical issues are looked after by the College
of Medicine Research Ethics Committee. The final approval of the
research proposal is granted by the CMRC Board on the basis of
reviewer‟s recommendations and Research Ethics Committee
report. The whole process takes about 12-14 weeks.

CMRC also provide full financial support to the postgraduate
medical students for their Masters and Doctoral studies.
Interested students can submit their applications through their
respective departments.

4. Research Laboratories

CMRC has well equipped laboratories where researchers can
independently conduct their experimental and laboratory work. At
present, the following facilities are available:




                                 9
a. Isolation, purification, and characterization of proteins,
   enzymes, antigens and antibodies employing the techniques
   of gel filtration, fast protein liquid chromatography (FPLC),
   electrophoresis, and isoelectric focusing (IEF).
b. UV/VIS Spectrophotometery; Enzyme kinetics studies.
c. Extraction, purification and characterization of DNA, RNA.
d. Amplification of RNA/DNA by polymerase chain reaction
   (PCR).
e. Detection of amplified products by ELISA and sub-marine gel
   electrophoresis.
f. Manual DNA sequencing and STR typing.

CMRC staff at our research laboratories can provide their
expertise to train your technical staff to carry out various types of
laboratory work independently. At the same time they can also
help in designing your laboratory protocols. .

5. Center for Laboratory Animals and Experimental Surgery
(CLAES)

Laboratory animals have played a key role in the advancement of
medical sciences. In the absence of human data, research
involving laboratory animals is the only and most reliable means
of evaluating the effects of a drug, trying a new surgical
approach, or studying the radiation effects. CLAES has a variety
of species including rats, mice, rabbits, guinea pigs and dogs.
Monkeys are going to be added soon in the list. Plans are
underway to improve the animal housing according to the
international standards. X-ray and surgical facilities are being
upgraded.




                                 10
6. Data Analysis

Analysis and interpretation of scientific data is of fundamental
importance in scientific research. CMRC has two highly skilled
statisticians who can be approached for any type of statistical
consultation. They have made significant contributions in several
CMRC and KACST approved research projects.

All of the above mentioned services and facilities are available
throughout the year. CMRC is trying its best to improve the
existing services to meet the new challenges, especially in the
field of medical information and literature search.

In addition to creative thinking, element of curiosity and instinct of
innovation, scientific research work also requires utmost
concentration, recent knowledge and plenty of time. Conferences,
symposia, workshops and clinical updates are the events which
carries tremendous practical significance. These venues provide
excellent opportunity and an amicable environment for learning,
exchange of first-hand information, and improving knowledge and
clinical skills. The participants have a chance to listen and interact
with eminent scholars and speakers. In view of their great
academic/professional need and importance, CMRC is planning
to organize research conferences, symposia, workshops and
seminars in the near future. It is hoped that these events will
definitely improve the quality of research and medical care at our
institution.

Medical science has made tremendous progress over the past
few years. The concept of molecular medicine has completely
changed the medical practice. Molecular diagnosis and
individually tailored gene therapy are shaping-up to replace the
conventional laboratory diagnosis and broad spectrum antibiotic


                                 11
therapy. We have already witnessed the transition from
chromosomes to genes. Stem cell research and its limited trial
has already been allowed in some countries. The art and science
of medicine and medical practice both are miraculously changing.
Exhaustive efforts are needed to cope-up with the growing needs
for better health care and a healthy future. CMRC is ready to
provide every possible facility to meet this challenge.

Finally, I would like to extend my sincere appreciation and thanks
to Prof. Mohammed M. Al-Mugeiren, Dean of College of Medicine
and Supervisor of University Hospitals, King Saud University, for
his skillful guidance and continuous support for CMRC. I am also
grateful to Prof. Ali Bin Saeed Al-Ghamdi, Dean, Scientific
Research at King Saud University, for his keen interest, valuable
suggestions and financial support. I would also like to extend my
deepest thanks and warmest regards to all members of the
CMRC Board, and the Research Ethics Committee, for sparing
their precious time to review the research proposals and
participate in the board meetings.

I truly would like to take this opportunity to convey my sincere
regards and thanks to the entire CMRC staff for putting their
tremendous efforts in encouraging, facilitating, and promoting
scientific research at this institution. I hope that the quality of
services at the CMRC will progress further to meet the ever
growing challenges in the field of medical research.


                          Prof. Abdulrahman S. Al-Arfaj
                          Director
                          College of Medicine Research Center




                                12
 CMRC ORGANIZATION
1424-1425 A.H. (2003-2004)

            DEANS
 Prof. Mohammed M. Al-Mugeiren
    Dean of College of Medicine

  Prof. Ali Bin Saeed Al-Ghamdi
    Dean of Scientific Research


          DIRECTOR
  Prof. Abdulrahman S. Al-Arfaj


    BOARD MEMBERS
    Prof. Nasir A. Al-Jurayyan
      Prof. Ali S. Al-Tuwaijri
     Prof. Suliman R. Alballa
 Prof. Abdelrahman M. Al-Tahan
  Prof. Ahmed M. Abu El-Asrar




               13
14
                         CMRC STAFF

RESEARCH ASSISTANTS
1) Dr. AbdulRauf Chaudhary
2) Dr. Youssef El-Nahas
3) Dr. Bahy Syed El-Masry
4) Dr. Muminul Hoque Siddique
5) Dr. Arthur Chavez Isnani
6) Dr. Khadija Fatima
7) Dr. Kazi Nur Asfina
8) Dr. Najma Khalil

TECHNICIANS
1) Logman Gasmalseed                  Lab. Technician
2) Nessrin Jadu                       Lab. Technician

BIOSTATISTICS
1) Dustan Kangave                     Statistician
2) Amir Salah Marzouk                 Statistician

MEDICAL INFORMATION (MEDLINE)
1) Saleh Abu Al-Ghaith                Medical Secretary

SECRETARIES
1) Hassan Ali Mansour                 Data Encoder
2) Vergie Vicente                     Medical Secretary




                                15
                            STAFF
           Center for Laboratory Animals
              & Experimental Surgery
                         (CLAES)

1) Dr. Kamal Mohammad Attia         Veterinarian
                                    (Supervisor)
2) Dr. Bandar Al-Mohimeed           Veterinarian
3) Osman Mahmoud Osman              Technician
4) Jamal Abdul Ghani                Technician
5) Adel Abdul Ghani                 Technician
6) Awad Ahmed Abdullah              Assistant Technician




                              16
                              CMRC ACHIEVEMENTS
                      RESEARCH PROJECTS APPROVED BY CMRC
                            1423-1424 A.H. (2002-2003)

S.No.                 Project Title                    Principal                 Date
                                                       Investigator             Approved
1)      02-443       An open-label, random-             Dr. M. Arafah           19.02.1424
        ized, multicenter, phase                        (Medicine)              21.04.2003
                     IIIb, parallel group study
                     to compare the efficacy and
                     safety of rosuvastatin and
                     atorvastain in subjects with
                     type IIa and IIb hyperchole-
                     sterolemia.

2)      03-444      Immunopathogenesis of               Prof. A. Abu El-Asrar   30.12.1423
                    conjunctival remodeling in          (Ophthalmology)          03.03.2003
                    vernal keratoconjunctivitis.

3)      03-445      Expression of CXCR3-                Prof. A. Abu El-Asrar   30.12.1423
                    binding chemokines in               (Ophthalmology)          03.03.2003
                    vernal keratoconjunctivitis.

4)      03-446      Evaluation of nitrous oxide          Dr. A. Samarkandi      28.01.1424
                    in the gas mixture for               (Anesthesia)           31.03.2003
                    anesthesia: a randomized,
                    controlled trial (ENIGMA trial).

5)      03-447      Prevalence of human                 Dr. Mona Badr           25.03.1424
                    parvovirus B19 in blood             (Pathology)             26.05.2003
                    donors and patients with
                    chronic hemolytic disorder.
                                                                                        cont…

Approved projects 1423-1424 (2002-2003) cont…


S.No.                 Project Title                    Principal                 Date
                                                       Investigator             Approved

6)      03-448      Effects of natural honey            Prof. A.T.M. Ali        09.04.1424
                    and amoxicillin against             (Pharmacology)          09.06.2003
                    gastric lesions induced by
                    chronic administration of
                    ammonia in rats.

7)      03-449      Bispectral index (BIS) and          Dr. A. Samarkandi       23.04.1424
                    titration of anesthetics            (Anesthesia)            23.06.2003


                                                 17
              in off pump coronary
              artery bypass (CAB).

8)   03-454   Role of Leptin in non-        Prof. I. Al-Mofleh   23.04.1424
              alcoholic fatty liver         (Medicine)           23.06.2003
              disease.

                          -----------




                                       18
   SUMMARIES OF
  CMRC-APPROVED
      PROJECTS

1423 to 1424 (2002-2003)




           19
20
                 CMRC RESEARCH GRANT NO.            02-443
Project Title:              An open-label, randomized, multi-center, phase
                            IIIb, parallel group study to compare the
                            efficacy and safety of rosuvastatin and
                            atorvastatin in subjects with type IIa and IIb
                            hypercholesterolemia.
Principal Investigator:     Dr. Mohamed Arafah
Department:                 Medicine
Co-investigators:
Date Approved:              19.02.1424 (21.04.2003)
Project Summary:
This study will be conducted in about 2023 enrolled subjects in order to
provide 1362 evaluable subjects. It is planned that each center will enroll a
minimum of 9 subjects. The primary objective of the study is to compare the
efficacy of rosuvastatin 10 mg with atorvastatin 10 mg by assessment of the
percentage of subjects who reach EAS LDL-C target goals after 12 weeks of
therapy.
This is a randomized, multi-center, open-label, 2 arm, and parallel group
study. Subjects will be selected from primary care physician practices from a
primary or secondary prevention subject population, male or female, 18
years or older, with primary hypercholesterolemia and with the following
characteristics: (a) subjects switched from start doses of other lipid lowering
therapy should have an LDL-C level >3.1 mmol/L (120 mg/dL); (b) naïve
subjects should have an
                                                                        cont…


LDL-C level >3.5 mmol/L (135 mg/dL); (c) CV risk >20% (as defined in
The Joint European Guidelines) or a history of CHD or other established
atherosclerotic (Appendix K) disease. Key exclusion criteria: history of SAE
with another HMG-CoA reductase inhibitor; active liver disease, severe
hepatic or renal impairment, treatment with cyclosporine or any disallowed
drug, subjects with unstable angina.
Subjects will be randomized to be treated for 12 weeks with rosuvastatin 10
mg or atorvastatin 10 mg therapy once daily (see figure 1, study flow chart).
At the end of the 12 week-study period, subjects may continue on
rosuvastatin treatment in an open extension period up to local launch time
subject to local regulations. Subjects will be evaluated based on an intention
to treat (ITT) population. The ITT population will consist of subjects who have
a baseline reading, one week 12 reading and at least one dose of trial



                                     21
medication. If a subject is withdrawn prior to week 12, then the last post
baseline assessment taken will be carried forward as the week 12 value.
The analysis will investigate the numbers of subjects reaching and not
reaching target on rosuvastatin and atorvastain at week 12. This will be
compared using a logistic regression analysis with factors being fitted for
treatment, country and subject type (naïve or switched) and treatment-by-
patient type interaction and the pre-dose lipid parameter value fitted as a
covariate. If the treatment-by-patient type interaction term is found to be
significant (p0.05), the nature of the interaction will be investigated;
otherwise the term will be dropped from the final model. The results will be
presented as odd ratios, with associated 95% confidence interval and p-
value.
                                                                     cont…


The demographic characteristics of height, weight, body mass index, blood
pressure    and      smoking status, along with Coronary Heart Disease
(yes/no) and 'actual risk' factors will be summarized by treatment group and
will be summarized for all subjects (both treatment groups combined). Data
regarding medical history, physical examination findings, concomitant
medications will also be recorded.
The incidence of adverse events will be summarized by treatment dose. With
regard to laboratory safety data, change from baseline and percentage of
values out-of-range will be described over time.
Data from different countries may be pooled in order to perform a similar
comparison across a number of countries. Assumptions of the analyses will be
explored and, if necessary, appropriate transformations or non-parametric
analysis techniques will be used.




                                    22
                 CMRC RESEARCH GRANT NO.            03-444
Project Title:              Immunopathogenesis of conjunctival remodeling
                            in vernal keratoconjunc-tivitis.
Principal Investigator:     Prof. Ahmed M. Abu El-Asrar
Department:                 Ophthalmology
Co-investigators:           Dr. Samir Al-Mansouri, Prof. K. Geboes
Date Approved:              30.12.1423 (03.03.2003)
Project Summary:
Vernal keratoconjuctivitis (VKC) is an allergic chronic seasonally exacerbated
bilateral external ocular inflammation. Chronic conjunctival inflammation in
VKC is associated with conjunctival remodeling, in particular epithelial
hyperplasia, extensive deposition of extracellular matrix proteins, and
possibly angiogenesis.       The mechanisms by which chronic conjunctival
inflammation in VKC promotes conjunctival remodeling have not been
clarified yet. The aims of this study are to investigate the processes involved
in mediating conjunctival remodeling in VKC by investigating the expression
of: (1) epidermal growth factor receptors (EGFR); (2) vascular endothelial
growth factor (VEGF), transforming growth factor- (TGF-), basic fibroblast
growth factor (bFGF), and platelet derived growth factor (PDGF); (3) the
integrin receptors 3, and 6 subunits; and (4) Ki67 antigen which is a
marker for cell proliferation. Conjunctival biopsy specimens from 20 subjects
with active VKC, and 10 control subjects will be studied by
immunohistochemical techniques using a panel of monoclonal and polyclonal
antibodies directed against the integrins 3,
                                                                        cont…




and 6 subunits, Ki67 antigen, EGFR, VEGF, TGF-, bFGF, and PDGF. The
phenotype of inflammatory cells expressing growth factors will be examined
by sequential double immuno-histochemistry.




                                     23
                 CMRC RESEARCH GRANT NO.          03-445
Project Title:             Expression of the CXCR3-binding chemokines in
                           vernal keratoconjunc-tivitis.
Principal Investigator:    Prof. Ahmed M. Abu El-Asrar
Department:                Ophthalmology
Co-investigators:          Dr. Soliman Al-Kharashi, Prof. J. Van Damme,
                           Prof. K. Geboes
Date Approved:             30.12.1423 (03.03.2003)
Project Summary:
Vernal keratoconjunctivitis (VKC) is an allergic chronic seasonally
exacerbated bilateral external ocular inflammation. Massive infiltration of
activated T lymphocytes bearing the chemokine receptor CXCR3 is a
hallmark of the lesions of VKC. Several studies demonstrated that CD4+ T
lymphocytes in VKC express T helper-2 type cytokines that might play a
central role in the pathogenesis of VKC. The mechanisms governing the
recruitment of T lymphocytes to the conjunctiva in VKC are not fully
understood. The use of chemokine antagonism as a strategy to inhibit
leukocyte trafficking into inflammatory sites requires identification of the
dominant chemokines mediating recruitment in specific pathologies. The aim
of this study is to examine the expression of the 3 interferon- (IFN-)-
inducible CXCR3-binding chemokines CXCL10/IP-10 (IFN--inducible protein
of 10 KDa), CXCL9/Mig (monokine induced by IFN-), and CXCL11/I-TAC
(IFN-inducible T-cell  chemoattractant) in the conjunctiva of patients with
VKC. These chemokines exhibit potent T lymphocyte chemoattractant activity.
                                                                     cont…


Conjunctival biopsy specimens from 20 patients with active VKC and 10
control subjects will be studied by immunohistochemical techniques using a
panel of monoclonal antibodies directed against IP-10, Mig, and I-TAC. The
phenotype of inflammatory cells expressing chemokines will be examined by
double immunohistochemistry.




                                    24
                 CMRC RESEARCH GRANT NO.           03-446
Project Title:              Evaluation of nitrous oxide in the gas mixture for
                            anesthesia: A randomized controlled trial.
Principal Investigator:     Dr. Abdulhamid H. Samarkandi
Department:                 Anesthesia
Co-investigators:           Dr. Abdulazeem El-Dawlatly, Dr. Ahmed
                            Turkistani, Dr. Wadha Al-Otaibi
Date Approved:              28.01.1424 (31.03.2003)
Project Summary:
There are some compelling reasons to question the routine use of N 2O. It is
clear that brief exposure to N2O impairs methionine synthetase, DNA
production, red and white blood cell formation. Tissue hypoxia may be more
common. These adverse effects are enhanced in sick high risk patients. The
extent of wound infection and cardiac morbidity associated with N 2O is not
known. Large outcome trial data are lacking. Therefore, the present large
multicenter randomized controlled study is going to be conducted in
collaboration with Prof P. Myles from Alfred Hospital in Australia (principal
investigator). Two groups of patients will be studied, Group I, where N2O
70% will be used with the mixture of gases, Group 2 where no N 2O will be
used. The following measurements will be taken:
Primary endpoint: hospital length of stay; secondary endpoints: wound
infection, severe vomiting, quality of recovery, ICU length of stay and 30-
day mortality; safety endpoints: myocardial infarction, venous
thromboembolism, stroke, awareness, blood transfusion pneumonia or
pneumothorax.
                                                                       cont…



Study duration: 3 years. Interim analysis will be performed after enrolment
of 800 and 1500 patients; results will be made available to the Data
Monitoring & Safety Committee (DMSC) (stopping rule: p-value less than
0.001).




                                    25
                 CMRC RESEARCH GRANT NO.            03-447
Project Title:               Prevalence of human parvovirus B19 in blood
                             donors and patients with chronic hemolytic
                             disorders.
Principal Investigator:      Dr. Mona A. Badr
Department:                  Pathology
Co-investigators:            Dr. Medhat Shier, Dr. Khadija Kurbaan
Date Approved:               25.03.1424 (26.05.2003)
Project Summary:
Background: Human parvovirus 19 is a non-enveloped, single stranded DNA
virus with a predilection for infecting rapidly dividing cell lines such as bone
marrow erythroid progenitor cells. Parvovirus B19 effect ranges from
asymptomatic infection to life-threatening aplasia, fetal anemia and death in
utero.
Project significance: Human parvovirus has been associated with several
diseases: erythema, infectiosum, aplastic crisis in chronic hemolytic anemia,
arthritis and intrauterine infection with hydrops fetalis. Parvovirus B19's site
of replication is the red blood cell precursor in the bone marrow. Infection
will cause a temporary shutdown in the red blood cell population. This causes
a significant drop of hemoglobin content, especially in patients with chronic
hemolytic disorders. Transmission of human parvovirus B19 by blood is well
documented.        Blood transfusion testing for human parvovirus B19 is
particularly important in the risk patient group that needs multiple blood
transfusions, like patients with chronic hemolytic disorders.
                                                                         cont…


Project aims: This project will aim to study prevalence of human parvovirus
B19 infection of blood donors at KKUH. The study will also determine
prevalence of parvovirus B19 infection in a group of patients with chronic
hemolytic disorders visiting the outpatient clinic.
Project approach and tools: Blood donors will be tested using specific IgM
and IgG antibodies using Enzyme Linked Immunosorbent Assay (ELISA). The
patients will be tested for specific IgM and IgG parvovirus B19 antibodies,
and parvovirus B19 DNA using real-time PCR. Comparison will also be made
between detection of human parvovirus B19 infection using ELISA technique
and real-time PCR.




                                      26
                 CMRC RESEARCH GRANT NO.            03-448
Project Title:               Effects of natural honey and amoxycillin against
                             gastric lesions induced by chronic administration
                             of ammonia in rats.
Principal Investigator:      Prof. A.T. Mobarok-Ali
Department:                  Medical Pharmacology
Co-investigator:             Dr. Mouied Alashari
Date Approved:               09.04.1424 (09.06.2003)
Project Summary:
Background: There is evidence to suggest that the gastrointestinal lesions
occur as a result of imbalance between the aggressive and defensive factors.
Numerous studies have shown that Helicobacter pylori are associated with
chronic gastritis and peptic ulcer diseases. H. pylori have high urease activity
resulting in high concentration of ammonia in the stomachs of H. pylori-
infected patients. Since ammonia is highly cytotoxic, its production by urease
of H. pylori makes it an important aggressive factor in mucosal injury.
Importance: Both honey and amoxycillin have been shown to possess gastric
protection effects against different models of experimentally induced gastric
lesions. Recently, honey has been shown to afford protection against acute
ammonia-induced gastric lesions in rats. Successful completion of this project
may provide the scientific support for the use of honey alone or in
combination with amoxycillin in the treatment of peptic ulcer diseases
associated with H. pylori.
                                                                         cont…


Aim: To investigate the potential gastroprotective effects and the possible
mechanisms(s) of action of honey and amoxycillin given orally either alone or
in combination on gastric lesions induced in rats by chronic administration of
ammonium hydroxide.
Method: Ammonium hydroxide 0.1% or 0.2% in a volume of 1 ml will be
given daily orally to the different groups of animals for a period of 4 or 6
weeks. Different doses of honey and amoxycillin either alone or in
combination will be given orally twice daily for a period of 4 or 6 weeks.
Control groups will receive water. Animals will be killed after 4 or 6 weeks
and macroscopic, biochemical, and histopathological evaluation will be
performed by using appropriate standard method discussed in the method
sections.




                                      27
                 CMRC RESEARCH GRANT NO.           03-449
Project Title:              Bispectral index (BIS) and titration of anesthetics
                            in off-pump coronary artery bypass (CAB).
Principal Investigator:     Dr. Abdulhamid H. Samarkandi
Department:                 Anesthesia
Co-investigators:           Dr. Waleed Riad, Dr. Mohammad Essam, Dr.
                            Khalid Abdullah
Date Approved:              23.04.1424 (23.06.2003)
Project Summary:
For mainly economic reasons, the recent trend in cardiac surgery has been to
extubate patients during the early postoperative period. Awareness after
anesthesia is of concern to patients and anesthesiologists alike especially in
cardiac surgery. The BIS can be used intraoperatively to reduce the amount
of anesthetics without increase in incidence of awareness.
The aim of this study is to evaluate the bispectral index (BIS) as a newly
introduced monitoring tool in cardiac surgery, for assessment of depth of
anesthesia and its effects on titration of anesthetic use and incidence of
awareness.
This is a controlled, prospective, randomized, and double-blind study. It will
include 40 patients of both sexes, ASA II-IV, who requires off-pump coronary
artery bypass graft surgery (OPCABG). Patients will be divided randomly
into two groups, the BIS and the control groups. BIS group will be managed
according to the BIS monitoring with a target value of 50.
                                                                        cont…


Control group will be managed clinically, as usual without the use of BIS
monitoring.
Anesthesia is to be induced with sufentanil, midazolam and rocuronium. The
rate of infusion and bolus doses of these anesthetic agents to be changed
and controlled as necessary as indicated by either the BIS reading value of
50 (in the BIS group), or clinical judgment (in the control group), and if
needed sevoflurane may be added. All patients will be interviewed twice at
the end of the first 2 days postoperatively to measure the incidence of
awareness.




                                     28
                 CMRC RESEARCH GRANT NO.             03-454
Project Title:               Role of leptin in non-alcoholic fatty liver disease
                             (NAFLD).
Principal Investigator:      Prof. Ibrahim I. Al-Mofleh
Department:                  Medicine
Co-investigators:            Dr. Reda Al-Badawy, Dr. Eman El-Eteer, Prof.
                             Faleh Al-Faleh, Prof. Hussain Al-Freihi, Dr. Saleh
                             Al-Amro
Date Approved:               23.04.1424 (23.06.2003)
Project Summary:
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease
characterized by diffuse fatty infiltration and inflammation. It has a
worldwide distribution. Patients with NAFLD are more susceptible to develop
liver cirrhosis than patients with steatosis. Moreover, liver-related mortality
for patients with NAFLD is high. Interestingly, NAFLD recurred in 33% of
patients who underwent liver transplantation and 12.5% progressed to
cirrhosis within one year of transplant.
The pathogenesis of NAFLD is yet to be clearly elucidated. Leptin, an (Ob-
gene) product is now receiving a great attention in liver disease. It is
produced from adipose tissue as well as extra-adipose tissues like the
stellate cell of the liver. Additionally, sinusoidal endothelial cell and Kupffer
cells express functional Obese Receptor (Ob-R), through which leptin
increases tissue growth factor  (TGF mRNA) which is a major candidate of
fibrosis. Therefore, it is postulated that leptin is one of the key mediators of
progression of hepatic fibrosis in patients with NAFLD.
                                                                           cont…




From the above-mentioned data, we found it interesting to investigate the
role of leptin in NAFLD by measuring serum leptin levels and correlating
these levels with biochemical markers of liver disease and results of liver
biopsy.
For this purpose 100 NAFLD patients will be studied and divided into two
groups: (a) HCV NAFLD group, and (b) diabetic and hyperlypidemic NAFLD
group. Apparently, 50 healthy volunteers will be considered as control
group matched for age and sex.




                                      29
38
                           CMRC ACHIEVEMENTS
                    RESEARCH PROJECTS APPROVED BY CMRC
                          1424-1425 A.H. (2003-2004)

S.#                Project Title                    Principal                 Date
No.       Investigator                              Approved

1)    01-420      Information disclosure             Prof. A. Al-Mobeireek   12.04.1425
                  and ethical decision-              (Medicine)              31.05.2004
      making in Saudi Arabia.
2)    03-450      Hemoglobin desaturation            Dr. A. Samarkandi       13.11.1424
                  after off succinylcholine-         (Anesthesia)            05.01.2004
                  induced apnea in patients.
3)    03-451      Oral megapulse methyl-            Prof. M.Al-Khawajah      25.12.1424
                  prednisolone in alopecia           (Dermatology)           16.02.2004
                  universalis, totalis &
                  ophiasis.
4)    03-452      Diabetic complications             Prof. J. Al-Wakeel      13.11.1424
                  in Saudi Arabia: a retros-         (Medicine)              05.01.2004
                  pective study of 1000
                  diabetic patients.
5)    03-453      Impairment of neuro-               Prof. J. Al-Wakeel      13.11.1424
                  physiological and                  (Medicine)              05.01.2004
                  cognitive functions in
                  renal failure.
6)    03-456      The production of PGE2             Dr. M. Alzoghaibi       13.11.1424
                  and the eosinophil                 (Physiology)            05.01.1424
                  chemokines, eotaxin,
                  and IL-5 in the serum of
                  Asthmatic Saudi patients.
                                                                                     cont…




                                               39
Projects 1424-1425 (2003-2004) cont…

S.#               Project Title                    Principal               Date
No.      Investigator                              Approved
7)    03-457    The effect of Ramadan               Dr. H. Mubarak        13.11.1424
                fast on pulmonary                   (Medicine)            05.01.2004
                function in asthmatic and
                healthy subjects.
8)    03-458    Effects of Islamic fasting          Dr. A. Bahammam       13.11.1424
                during Ramadan on                   (Medicine)            05.01.2004
                daytime alertness, mood,
                cognitive function, and
                chronotype.
9)    03-459    Lung function and respi-           Dr. S. Meo             25.12.1424
                ratory findings in subjects (Physiology)                  16.02.2004
                exposed to crude oil
                spill in sea water.
10) 03-460      Haemostatic changes in              Prof. A.M.A. Gader    12.04.1425
                laparoscopic cholecys-                                    31.06.2004
                tectomy.
11) 03-461      Use of dexamethasone                Dr. A. Samarkandi     23.01.1425
                to reduce postoperative             (Anesthesia)          14.03.2004
                vomiting and pain after
                paediatric tonsillectomy
                procedures.
12) 03-462      A double-blind, random-             Prof. A. Al-Tahan     22.01.1425
                ized, placebo-controlled,           (Medicine)            13.03.2004
                multicenter trial to inves-
                tigate the efficiency and
                tolerability of topiramate
                in prolonged migraine
                prevention.
                                                                                  cont…

Projects 1424-1425 (2003-2004) cont…

S.#               Project Title                    Principal               Date
No.      Investigator                              Approved

13) 03-464      The dose of succinyl-              Dr. A. Samarkandi      26.04.1425
                choline required for               (Anesthesia)           14.06.2004
                excellent intubating
                conditions.

14) 03-465      Efficacy and safety of             Prof. A.Abu El-Asrar   12.04.1425
                infliximab in panuveitis           (Ophthalmology)        31.05.2004




                                              40
15) 03-466   Serum antioxidant                  Dr. M. Alzoghaibi    08.02.1425
             enzymes granulocytes               (Physiology)         29.03.2004
             chemotactic protein
             (GCP-2) levels in compa-
             rison to interleukin-8 in
             Crohn's Saudi patients.

16) 03-468   Randomized prospective             Dr. K. Fouda-Neel    20.11.1424
             study to see the effect            (Surgery)            12.01.2004
             of botulinum – a toxin
             intravesically as a solo
             treatment for non-
             compliant neuropathic
             bladder.

17) 04-471   Clinical utility of amlodi-        Prof. J. Al-Wakeel   21.03.1425
             pine/atorvastatin to               (Medicine)           10.05.2004
             improve concomitant
             cardiovascular risk
             factors of hypertension
             and dyslipidemia.
                                                                           cont …




                                           41
Projects 1424-1425 (2003-2004) cont…

S.#            Project Title                      Principal               Date
No.                                               Investigator           Approved

18) 04-472     Expression of apoptosis            Prof. A.Abu El-Asrar   08.02.1425
               markers in retinas of              (Ophthalmology)        29.03.2004
               human subjects with
               diabetes.

19) 04-473     Hepatitis B genotypes in           Dr. A. Abdo            12.04.1425
               Saudi Arabia and its               (Medicine)             30.05.2004
               effect on clinical progres-
               sion of hepatitis B.

20) 04-474     Utility of measuring               Dr. A. Abdo            12.04.1425
               protein-S level in                 (Medicine)             31.05.2004
               reptilase time in patients
               with liver disease.

21) 04-475     Blood pressure control             Dr. K. Alsuwaida       04.05.1425
               and salt intake in Saudi           (Medicine)             22.06.2004
               diabetic hypertensive
               patients.
                       




                                             42
   SUMMARIES OF
  CMRC-APPROVED
      PROJECTS

1424 to 1425 (2003-2004)




           43
44
                 CMRC RESEARCH GRANT NO.            01-420
Project Title:              Information disclosure and ethical decision-
                            making in Saudi Arabia.
Principal Investigator:     Prof. Abdullah F. Al-Mobeireek
Department:                 Medicine
Co-investigator:            Prof. Feisal Al-Kassimi
Date Approved:              12.04.1425 (31.05.2004)
Project Summary:
Physician-patient relationship is an old subject that has faced new challenges
in the past few decades. This is due to the vast development in the
'electronic' information era and diagnostic and therapeutic modalities. The
role of the patient, his family, and the doctor in the decision-making process
is subject now to controversial positions, which are influenced to a large
extent by cultural values and norms. Despite a wealth of studies on this
subject in Western countries, studies in Arab countries are very few.
In this study, we propose to study a group of doctors, patients and patient's
relatives in different areas of the Kingdom. Our objective is to get insight to
their concept of roles of the patient, his relatives and the doctor, and the
limits of authority of each party.
We will use a validated instrument (questionnaire) which has been previously
used in USA and Japan and, thus, facilitate comparison with our results. This
questionnaire contains a number of different clinical scenarios, broadly
covering subjects of current importance to the society, such as cancer, human
immunodeficiency virus (HIV), physician-assisted suicide (PAS), and ventilation
in terminal illnesses.



                 CMRC RESEARCH GRANT NO.            03-450
Project Title:              Hemoglobin desaturation after of succinylcholine
                            induced apnea in patients.
Principal Investigator:     Dr. Abdulhamid H. Samarkandi
Department:                 Anesthesia
Co-investigators:           Dr. Waleed Riad Hussain, Dr. Saleh Al-Harbi
Date Approved:              13.11.1424 (05.01.2004)
Project Summary:
Succinylcholine remains the drug of choice during a rapid-sequence induction
of anesthesia. However, it has been demonstrated that spontaneous recovery
from 1.0 mg/kg succinylcholine-induced apnea may not occur rapidly enough



                                     45
to prevent hemoglobin desaturation in subjects whose ventilation is not
assisted (can't intubate and can't ventilate situation).
The aim of this prospective, randomized study is to investigate whether
spontaneous respiration recovers in time to prevent significant hemoglobin
desaturation after the administration of smaller doses of succinylcholine in
healthy patients.
After preoxygenation with 100% oxygen for 3 min, anesthesia will be
induced in 60 patients with 2g/kg fentanyl and 2mg/kg intravenous
propofol. Patients will be randomly allocated to three groups (n=20 each)
to receive either 0.56, 1.0 mg/kg succinylcholine or saline (control group).
Ventilation will be assisted only if the hemoglobin saturation
                                                                          cont…


decreased to 90%. This level of hypoxia is chosen based on the SaO 2
tolerated by subjects in studies of pulse oximeter accuracy and hypoxic
ventilatory responsiveness.
Throughout the period from loss of consciousness, the investigators will talk
gently to patients, reassuring them that all is well and that everything is under
control. The duration of apnea and the degree of hemoglobin desaturation
will be noted in each group.




                                      46
                 CMRC RESEARCH GRANT NO.            03-451
Project Title:               Oral mega pulse methylprednisolone in alopecia
                             universalis, totalis and ophiasis.
Principal Investigator:      Prof. Marwan Al-Khawajah
Department:                  Dermatology
Co-investigator:             Dr. Ghada Bin Saif
Date Approved:               25.12.1424 (16.02.2004)
Project Summary:
High dose-intermittent intravenous CS is an alternative method of CS delivery
that proved to be safe, well tolerated with a rapid and potent therapeutic
efficacy in several diseases including renal transplantation, RA, SLE, multiple
sclerosis and pemphigus vulgaris. It has been proven to be effective in the
treatment of alopecia areata but not the totalis, universalis or ophiasis types,
for which no consistently effective therapy is available. Studies in which IV
pulse MP was used in the latter types involved small number of patients and
were inconsistent with regard to dosage, frequency or duration of therapy.
Most studies used single pulse/cycle or few pulses (2-4) given monthly or at
irregular intervals with no or only short follow-up. The dosage of MP ranged
from 100mg to 1000mg per day, but lower doses were given more
commonly regardless of the weight or age of the patients. The lack of
consistency of these studies made it difficult to conclude with certainty on the
efficacy of such a valuable and relatively safe, therapeutic modality in the
treatment of such sinister subsets of alopecia areata.
                                                                          cont…


The need to admit the patient for IV treatment was probably an important
deterrent from enrolment of sufficient number of patients. It has been
confirmed, however, that oral MP has similar clinical efficacy and range of
side effects to that of IV MP, when given in equal doses.
We, therefore, intend to study the short and long-term efficacy including the
rate of remission, the time to initial and maximum response and the rate and
duration of sustained remission with and without maintenance treatment, as
well as the toxicity in alopecia totalis, universalis, and ophiasis on an
outpatient basis. The treatment schedule comprises two phases:
1) Induction phase: our aim in this phase is to achieve cosmetically
acceptable hair regrowth in at least 90% of the affected scalp areas. By
the administration of oral MP sodium succinate as 15 mg/kg/day for 3
consecutive days, bimonthly for a maximum 12 cycles (24 weeks), patients
who show less than 90% response will be discharged from the study




                                      47
2) Maintenance phase: in this phase the re-growing hair will be maintained
by the same pulses given at increasingly longer intervals until a relapse-free
interval of 24 weeks have been achieved. In case of relapse, however, the
treatment intervals will be shortened to that which preceded the one with
relapse and the patient will be kept on pulse therapy to maintain hair
growth. In either case, patients will be followed up for a minimum of 2 years.




                                     48
                 CMRC RESEARCH GRANT NO.          03-452
Project Title:             Diabetic complications in Saudi Arabia: a
                           retrospective study of 1000 diabetic patients.
Principal Investigator:    Prof. Jamal S. Al-Wakeel
Department:                Medicine
Co-investigators:          Prof. Riad Sulimani, Dr. Suleiman Al-Mohaya, Dr.
                           Hani Al-Assad, Dr. Ghulam Malik, Dr. Ali Al-
                           Harbi
Date Approved:             13.11.1424 (05.01.2004)
Project Summary:
This is a retrospective study to determine the complications of diabetes
mellitus among Saudi diabetic patients. Hospital files of at least 1000
diabetic patients will be reviewed and important data will be extracted
including the demographic characteristics of the patients, age of onset and
diagnosis of diabetes, initiation of treatment, modalities used, presence of
risk factors, and history of complications. A detailed history of diabetic
complications and its pathogenesis will be noted (retinopathy, nephropathy,
cardiopathy, hypertension, stroke, amputations) together with interventions
done (laser therapy, dialysis, angioplasty, CABG, etc.). This study hopes to
present the evolution and prevalence of diabetic complications in Saudi
Arabia. Furthermore, we also aim to review the management protocols that
have been used together with other factors that may have contributed to the
rising incidence of diabetes mellitus among the Saudi population. Currently,
there has rarely been an extensive study done on diabetic complications in
the Kingdom on or in other centers in Saudi Arabia.




                                    49
                 CMRC RESEARCH GRANT NO.              03-453
Project Title:               Impairment of neurophysiological and cognitive
                             functions in renal failure.
Principal Investigator:      Prof. Jamal S. Al-Wakeel
Department:                  Medicine
Co-investigator:             Dr. Radwan Zaidan, Dr. Nauman Tarif, Dr.
                             Nawaz Memon, Dr. Akram Askrar
Date Approved:               13.11.1424 (05.01.2004)
Project Summary:
This is a prospective study to determine the cognitive and
electrophysiological impairment in Saudi patients with chronic renal failure
and the effect of dialysis in patients with chronic renal failure on the cognitive
functions which will run for 15 months. A total of 140 patients (40 patients
with moderate renal failure not necessitating dialysis, 80 patients on dialysis,
and 20 kidney transplant patients) will undergo cognitive clinical assessment,
mini mental status exam (MMS), digit span of Weschler Adult Intelligence
Scale (WAIS), electroencephalogram (EEG) and P300. All tests will be done
at the Neurophysiology Laboratory of King Khalid University Hospital.
Although impairment in cognitive functions in patients with renal failure has
been described in previous literatures, there were no studies done in our
institution or in other centers in Saudi Arabia.




                                       50
                 CMRC RESEARCH GRANT NO.          03-456
Project Title:              The production of PGE2 and the eosinophil
                            chemokines, eotaxin and IL-5 in the serum of
                            asthmatic Saudi patients.
Principal Investigator:     Dr. Mohammed Alzoghaibi
Department:                 Physiology
Co-investigator:            Dr. Ahmed BaHammam, Prof. Ali Al-Tuwaijri
Date Approved:              13.11.1424 (05.01.2004)
Project Summary:
Bronchial asthma is a chronic inflammatory disorder characterized by airway
inflammation by eosinophils and activated neutrophils (PMNs).             The
mechanisms that regulate the recruitment of these leucocytes in the inflamed
airway are areas of active investigation. Chemokines are a superfamily of
8-10 kd proteins that are potent chemoattractants for leukocytes. The C-C
chemokines eotaxin-1, interleukin-5 (IL-5) and the arachidonic acid
metabolite, prostaglandin E2 (PGE2) have been implicated in the
pathogenesis of asthma. Reactive oxygen species (ROS) have an important
role in tissue damage and inflammation. They enhance tissue destruction by
damaging the cellular membrane and increase the concentration of the
harmful product, lipid peroxide. Superoxide ( O2-) represents the precursor
element in the chain production of other ROS. Activated neutrophil is one of
the main sources of O2- production.

                                                                      cont…


The principal objectives of this study are to measure and compare the
concentrations of these cytokines with chemoattractant properties for
eosinophils in the serum of asthmatic Saudi patients and in normal control
subjects using EIA assay and also to measure the levels of superoxide
production from its main source, PMNs by chemiluminescence assay. In this
study, we will also look at the role of neutrophils in the production of
eosinophil chemokines (IL-5, eotaxin-1).




                                    51
                 CMRC RESEARCH GRANT NO.          03-457
Project Title:              The effect of Ramadan fast on pulmonary
                            function in asthmatic and healthy subjects.
Principal Investigator:     Dr. Hatem F. Al-Mubarak
Department:                 Medicine
Co-investigator:            Dr. Ahmed S. BaHammam
Date Approved:              13.11.1424 (05.01.2004)
Project Summary:
Introduction: The effect of Ramadan fast on human and health has been
studied from the biochemical, hormonal, and physiological aspects. It has
been our experience that some asthmatics have less control during the month
of Ramadan. We hypothesize that Ramadan fasting will cause airway
dehydration which will result on changes in pulmonary function and worsening
asthma symptoms in mild and moderate asthmatic.
Objectives: (1) To assess the effect of Ramadan fasting on pulmonary
function in healthy individuals compared to asthmatic subjects; (2) to assess
asthma control during Ramadan month.
Methodology: Thirty male volunteers will be studied; 10 mild to moderate
asthmatic Muslims, 10 healthy Muslims and 10 healthy non-Muslims. All
volunteers will be evaluated in three occasions. During Shaaban (BL), first
week of Ramadan (R1), and third week of Ramadan (R3) to assess the
pulmonary function using spirometric testing and to assess asthma
                                                                      cont…


control using questionnaire and daily measurements of home peak flow
meter.
Utilization: The relationship between Ramadan fasting and asthma control
has not been studied before. This study will provide us with a better
understanding of such relationship. It will enable us to modify or even renew
our approach toward asthma control during the month of Ramadan. This
study will also be the basis to explore and study the effect of Ramadan
fasting on other obstructive lung disease like emphysema, chronic bronchitis
and bronchiectasis.




                                    52
                 CMRC RESEARCH GRANT NO.           03-458
Project Title:              Effects of Islamic fasting during Ramadan on
                            daytime alertness, mood, cognitive function, and
                            chronotype.
Principal Investigator:     Dr. Ahmed S. BaHammam
Department:                 Medicine
Co-investigator:            Prof. Abdelrahman Al-Tahan
Date Approved:              13.11.1424 (05.01.2004)
Project Summary:
Introduction: During the month of Ramadan many people alter their sleeping
habits and stay awake most of the night. Many changes in lifestyle and habit
occur during Ramadan like opening stores and shopping malls until late at
night. One may assume that the above changes may affect daytime
alertness and sleepiness, chronotype and cognitive function of fast
performers. Therefore, does Ramadan fasting and its attendant changes in
lifestyle affect daytime alertness and circadian pattern?
Objectives: To assess the effect of fasting during Ramadan on chronotype
(morningness-eveningness self-assessment questionnaire); to assess the effect
of fasting during Ramadan on the cognitive function objectively (event-
related evoked potential); to assess the effect of fasting during Ramadan on
daytime alertness and mood using the global alertness and mood visual
analogue scales (VAS).
Methods: We will study 10 Muslim and 10 non-Muslim male healthy
volunteers during Shaban (BL), first week of Ramadan (R1) and third week
of Ramadan (R3) to assess cognitive
                                                                       cont…



function using event-related evoke potential (200), chronotype using
morningness-eveningness questionnaire and alertness and mood using the
global alertness and mood visual analogue scales.
Utilization: This project will allow us to assess systematically the potential
changes in cognition, chronotype, alertness and mood during Ramadan in
Muslims and non-Muslims and to know whether these changes are related to
fasting or to the lifestyle changes during Ramadan. Such findings are crucial
to refute or accept some conceptions about Ramadan and fasting.




                                     53
                 CMRC RESEARCH GRANT NO.              03-459
Project Title:               Lung function and respiratory findings in subjects
                             exposed to crude oil spill in sea waters.
Principal Investigator:        Dr. Sultan A. Meo
Department:                    Physiology
Co-investigator:               Dr. Thamir Al-Khalaiwi
Date Approved:                 25.12.1424 (16.02.2004)
Project Summary:
In the recent years, the international community has been facing increasingly
risks due to major accidents occurring near the marine areas. The
Mediterranean zones are most productive and vulnerable areas on the
planet but unfortunately their environment is exposed to series of hazards
including floods and oil spills in sea water. Oil spill in sea water is one of the
most sensitive and highly considerable problem all over the world especially
in the oil producing countries. Oil spill in sea water develops many
hazardous effects not only to kill the sea life but it also affects the human
lives residing in the marine vicinity and whom they are engaged to perform
their duties at coastal areas. Recently, the Tasman Spirit, Greek ship was
unluckily ran around and got a crack in its center and finally broken into two
pieces and oil was spilt into the sea water at marine areas of Karachi,
Pakistan. Therefore, the idea is to observe the lung function and respiratory
findings in subjects exposed to crude oil spill in sea water.
                                                                          cont …




In this study, a group of 50 apparently healthy volunteer male subjects will
be selected from the subjects living in the vicinity and/or performing their
duties at the coastal belt areas of Karachi. They will be matched with
another group of 50 control healthy male subjects in terms of age, height,
weight and socioeconomic status. Both groups will meet with exclusion criteria
s per standard. Respiratory findings will be observed and spirometry will be
performed on an electronic spirometer (Compact Vitalograph, UK).




                                      54
                 CMRC RESEARCH GRANT NO.            03-460
Project Title:              Haemostatic      changes       in     laparoscopic
                            cholecystectomy.
Principal Investigator:     Prof. Abdel Galil M. A. Gader
Department:                 Physiology
Co-investigators:           Prof. Abdullah Al-Dohayan, Dr. Jamal Khairy, Dr.
                            Abeer Al-Ghumlas
Date Approved:              12.04.1425 (31.06.2004)
Project Summary:
The incidence of deep vein thrombosis and pulmonary embolism following
laparoscopic cholecystectomy (LC) is known to be lower than in open
cholecystectomy (OC). Many earlier hemostatic studies have shown that the
procoagulant coagulation abnormalities and platelet functions are more
pronounced in OC than LC. However, certain hemostatic tests, especially
tissue factor pathway inhibitor (TFPI) and platelet function as measured by
the newly employed platelet function analyzer (PFA 100) have not been
employed before in laparoscopic surgery. This study, which is to continue for
18 months, aims at monitoring TFPI, tissue factor (TF), natural coagulation
inhibitors (protein C and S and antithrombin III), and platelet function as
measured by the PFA 100.
One hundred patients (50 of each sex) will be recruited from patients
undergoing laparoscopic cholecystectomy at the surgical ward at KKUH. An
equal number of age and sex-matched healthy control will also be recruited,
10 ml citrated venous blood sample will be collected and the following
assays
                                                                       cont …




will be undertaken: (1) platelet function using the PFA 100, (2) total and free
TFPI ad TF using ELISA kits, (3) fibrinolytic parameters: plasminogen activator
inhibitor (PAI-1) and tissue plasminogen activator (tPA).
It is hopeful that the results obtained will throw more light on the hemostatic
changes that are associated with laparoscopic cholecystectomy. In addition
to being of academic interest, this study may be of potential applied nature.




                                     55
                 CMRC RESEARCH GRANT NO.          03-461
Project Title:              The use of dexamethasone to reduce
                            postoperative vomiting and pain after pediatric
                            tonsillectomy procedures.
Principal Investigator:     Dr. Abdulhamid H. Samarkandi
Department:                 Anesthesia
Co-investigators:           Dr. Mussarat Afzal, Dr. Rana Altaf
Date Approved:              23.01.1425 (14.03.2004)
Project Summary:
The incidence of postoperative emesis is more frequent in pediatric patients
than in adult. Incidence is increased after strabismus, tonsillectomy, and
orchidopexy procedures. Dexamethasone was first reported to be an
effective antiemetic agent in patients receiving cancer chemotherapy in
1981. Since then several studies have shown that dexamethasone is equal to
or better than other antiemetic agents in preventing nausea and vomiting
associated with chemotherapy. Recently, dexamethasone has also been
reported to be effective in prevention of nausea and vomiting in adults
undergoing laparoscopic and gynecological surgery and in children
undergoing tonsillectomy and strabismus surgery. Our study is designed to
evaluate the efficacy of dexamethasone as single antiemetic agent to reduce
the incidence of postoperative nausea and vomiting and pain in patients
undergoing tonsillectomy. It will be a randomized, double-blind, placebo-
controlled study. Patients will be allocated randomly to one of the two
groups (n=30 each) using a

                                                                     cont …


computer-generated random number table, one receiving dexamethasone
0.5 mg/kg and other group will receive saline at induction. The anesthetic
regimen and surgical procedure are standardized for all patients. After
surgery all patients will be observed in post anesthesia care unit (PACU) and
ward for 24 hours. In PACU patients will be observed for early vomiting or
pain and need for rescue antiemetic or analgesia. Incidence of late vomiting
in wards and the need for antiemetic will be recorded. Time for first oral
intake and quality of oral intake assessed. Parametric data will be analysed
by using Student's t-test. Categorical data will be analysed with Chi-squared
test.




                                    56
                 CMRC RESEARCH GRANT NO.            03-462
Project Title:               A double-blind, randomized, placebo-controlled,
                             multicenter trial to investigate the efficacy and
                             tolerability of topiramate in prolonged migraine
                             prevention.
Principal Investigator:      Prof. Abdelrahman Al-Tahan
Department:                  Medicine
Date Approved:               22.01.1425 (13.03.2004)
Project Summary:
This is a double-blind, randomised, placebo-controlled multicenter trial to
assess whether or not topiramate has continued efficacy beyond an initial six
months of treatment as a migraine prophylactic drug.
Subjects meeting the selection criteria will start with a 4-week prospective
baseline phase (no treatment is given) which is followed by a 26-week open
label treatment phase where topiramate (target dose 100mg/day) is
titrated to an individually optimized final dose which is kept stable during the
last 4 weeks. After this phase subjects will enter a 26-week, double-blind
treatment phase and will be randomized to receive either topiramate at the
final dose of the previous phase, or placebo. In the subsequent run-out phase
(1 week) the dose of the double-blind medication will be fully discontinued.
Primary efficacy parameter is the change in the number of migraine days
from the last 4 weeks in the open label phase to the last 4 weeks in the
double-blind phase.
                                                                        cont …



This change in migraine days will be compared between topiramate and
placebo treated subjects. At each trial visit, the subject's diary will be
evaluated, the dose of the trial medication adjusted if needed, and adverse
events recorded. Subject's health-related quality of life will be assessed by
self-administered questionnaires (MIDAS, HIT-6, SF-12) at specified visits.
Subject satisfaction with efficacy and tolerability of the trial medication will
be assessed at the end of the open label phase and at the end of the
double-blind phase.




                                      57
                 CMRC RESEARCH GRANT NO.             03-464
Project Title:               The dose of succinylcholine required for excellent
                             intubation conditions.
Principal Investigator:      Dr. Abdulhamid H. Samarkandi
Department:                  Anesthesia
Co-investigators:            Dr. Emad Abdelaziz, Dr. Ahmad Turkistani, Dr.
                             Khalid Sayed
Date Approved:               26.04.1425 (14.06.2004)
Project Summary:
The most commonly used dose of succinylcholine is 1.0 mg/kg. The reported
range of excellent intubating conditions following administration of 1.0
mg/kg succinylcholine is 63-85%. The dose of succinylcholine needs to be
individualized depending on the clinical situation.
The purpose of this prospective, randomised, double-blind, placebo-
controlled study is to determine the dose of succinylcholine required to
achieve excellent intubation conditions in 90-95% of patients within 60
seconds. This study will be utilized in future in giving the appropriate dose of
succinylcholine that provides excellent intubating conditions in special clinical
situations.
300 patients of both sexes, aged 18-45 years, ASA 1 will be randomly and
equally allocated into 6 groups: group 1 patients will receive 0.3 mg/kg
succinylcholine, group 2 patients will receive 0.5 mg/kg, group 3 patients will
receive 1.0 mg/kg, group 4 patients will receive 1.5 mg/kg, group 5
patients will receive 2 mg/kg, and group 6 patients will receive saline.
                                                                         cont …




The principal investigator will select the patients who will be included in the
study. The second investigator will give the study drug. The third investigator
will intubate the trachea and will assess the intubation conditions and will
grade it according to the criteria for grading tracheal intubation conditions.
Also, he will count the number of tactile TOF responses immediately after
tracheal intubation. The times from the start of nerve stimulation to
disappearance and reappearance of TOF count will be noted. The fourth
investigator will collect the data of the patients and perform statistical
analysis.




                                      58
                 CMRC RESEARCH GRANT NO.           03-465
Project Title:              Efficacy and safety of infliximab in panuveitis
                            associated with Behcet's disease.
Principal Investigator:     Prof. Ahmed M. Abu El-Asrar
Department:                 Ophthalmology
Co-investigators:           Dr. Hassan Al-Dhibi, Dr. Hamad Al-Fraikh, Dr.
                            Emad Abboud, Prof. Abdul- rahman Al-Arfaj
Date Approved:              12.04.1425 (31.05.2004)
Project Summary:
Ocular inflammation develops in about 60-80% of patients with Behcet's
disease. Permanent loss of vision resulting from relapsing ocular inflammation
occurs in about 20-50% of the patients within 5 years, despite intensive,
chronic immunosuppressive therapy. Tumor necrosis factor (TNF)-, a
proinflammatory cytokine, has an important pathogenetic role in Behcet's
disease. Infliximab, a mouse-human chimeric immunoglobulin G1 monoclonal
antibody, neutralizes both the soluble and the membrane-bound TNF- and
inhibits a broad range of biologic activities of TNF-. In this prospective
noncomparative case series study we are planning to study the efficacy and
safety of infliximab in Behcet's patients with sight-threatening panuveitis.
Fifteen consecutive patients diagnosed as having Behcet's disease according
to the International Study Group criteria associated with sight-threatening
panuveitis will be treated with infliximab. Intravenous infusion of 5mg/kg
infliximab will be given over 2hours at weeks 0, 2, 6, and then every 8
weeks. The intended treatment period is 6 months.
                                                                       cont…




All patients will undergo full ophthalmological and medical examination at
baseline. After initiation of infliximab therapy, patients will be examined
daily for 1 week, every 2 weeks for the first 2 months, then every 4 weeks.
The main outcome measures are visual acuity and rate of remission.




                                     59
                 CMRC RESEARCH GRANT NO.           03-466
Project Title:              Serum antioxidant enzymes and granulocytes
                            chemotactic protein (GCP-2) levels in comparison
                            to interleukin-8 (IL-8) in Crohn's Saudi patients.
Principal Investigator:     Dr. Mohammed Alzoghaibi
Department:                 Physiology
Co-investigators:           Prof. Ibrahim Al-Mofleh, Dr. Abdul-rahman
                            Algebreen
Date Approved:              08.02.1425 (29.03.2004)
Project Summary:
Crohn's disease can affect any level of the alimentary tract but the terminal
ileum and proximal colon are most frequently involved. According to an
epidemiological study done at KKUH in Riyadh, the annual incidence of the
disease over the last 10 years was 1.6:100,000 and over the last 20 years
was 0.94:100,000. Crohn's disease is a debilitating illness of the bowel. The
main pathological feature of this disease is the continuous infiltration of
polymorphonuclear neutrophils (PMN) and mononuclear cells in the affected
part of the intestine. The initial migration of PMN to the inflamed tissue is
beneficial because they produce noxious substances and proteases to kill
bacterial, but the continuous migration might cause inflammation and tissue
injury.
A classical feature of Crohn's disease is also the high production of collagen
from the affected part of the bowel with unknown cause. Persistent PMN
infiltration into the intestinal
                                                                      cont …



stricture may be due to the high production of interleukin-8 (IL-8) which
attracts PMN by the stricture itself and which already has been proven.
The aim of this study is to measure the concentration of another PMN
chemokine, granulocytes chemotactic protein-2 (GCP-2), in the serum of Saudi
Crohn's patients. And also, to measure the levels of the antioxidant enzymes,
such as superoxide dismutase and glutathione peroxidase to know the role of
these antioxidant enzymes in the progression of Crohn's disease in Saudi
patients.




                                     60
                 CMRC RESEARCH GRANT NO.            04-471
Project Title:               Clinical utility of amlodipine/ atorvastatin to
                             improve concomitant cardiovascular risk factors
                             of hypertension and dyslipidemia (Gemini-Aala).
Principal Investigator:      Prof. Jamal S. Al-Wakeel
Department:                  Medicine
Co-investigator:             Dr. Kerrayem Alsuwaida
Date Approved:               21.03.1425 (10.05.2004)
Project Summary:
Background: Approximately 16.6 million people die each year due to
cardiovascular disease, accounting for one-third of all annual deaths.
Hypertension and dyslipidemia are two of the major indicators that a person
may develop cardiovascular disease. Norvasc (amlodipine) and Lipitor
(atorvastatin) have generated extensive safety and efficacy worldwide for
treatment of hypertension and dyslipidemia, respectively.
Objective: To evaluate the efficacy of amlodipine/atorvastatin therapy by
assessing the percentage of intent-to-treat subjects achieving both BP and
lipid treatment goals as defined by the Joint National Committee (JNC)
Guidelines (Report VII) and National Cholesterol Education Program (NCEP)
Guidelines (NCEP ATPIII).
Materials and Methods: This is part of a collaboration of investigators
initiated by JAALA (Pfizer Group) from approximately 200 international
sites involving subjects with
                                                                        cont …


concomitant hypertension and dyslipidemia. This is a 14-week open-label
trial to gain clinical experience with a single pill combining amlodipine and
atorvastatin for the treatment of concomitant hypertension and dyslipidemia
in a naturalistic setting. Ten subjects with concomitant hypertension and
dyslipidemia will be recruited from KKUH. Eight dosage strengths of the
amlodipine/atorvastatin single pill will be available for use in this open-label
study. Subjects will receive one of the following dosage strengths of
amlodipine/ atorvastatin: 5mg/10mg, 5mg/20mg, 5mg/40mg, 5mg/80mg,
10mg/10mg. 10mg/20mg, 10mg/40mg or 10mg/80mg. Subjects will be
dispensed study medication at an appropriate dose for their current blood
pressure level, lipid levels, and concomitant therapies; doses will be titrated
over the 14 weeks to improve both blood pressure and lipid control as
necessary. Efficacy measures include blood pressure and lipid levels.
Routine clinical and laboratory safety will be monitored.


                                     61
Utilization: This is one of the first clinical trials dosing subjects with the
amlodipine/atorvastatin single pill that is bioequivalent to its parent
components. The major benefit includes management of cardiovascular risk
with improvement in both blood pressure and lipid levels.




                                     62
                 CMRC RESEARCH GRANT NO.           04-472
Project Title:              Expression of apoptosis markers in the retinas of
                            humans subjects with diabetes.
Principal Investigator:     Prof. Ahmed M. Abu El-Asrar
Department:                 Ophthalmology
Co-investigators:           Prof. Lieve Dralands, Prof. Luc Missotten, Prof.
                            Karel Geboes
Date Approved:              08.02.1425 (29.03.2004)
Project Summary:
Diabetic retinopathy is a major cause of blindness worldwide. The disease
includes retinal neurodegeneration as well as vascular pathologies.
Apoptosis is a process of programmed cell death that requires the synthesis
of new proteins by degenerating cells. Apoptosis has been implicated in the
death of retinal neural cells in diabetes. However, the molecular basis for
the apoptogenic effects of diabetes in the retina is not yet identified. The
use of antiapoptopic agents may provide a means to rescue and protect
retinal ganglion cells from apoptopic cell death induced by diabetes. In this
study we are planning to investigate the expression of the apoptopic
mediators in the retinas from human subjects with diabetes mellitus. Ten
postmortem eyes from five subjects with diabetes mellitus, and eight eyes
from four subjects without diabetes and without known ocular disease will be
examined. We shall use immunohistochemical techniques and antibodies
directed against glial fibrillary acidic protein (GFAP), caspase-3, Fas, Fas
ligand (FasL), Bax, Bcl-2, surviving, p53, extracellular signal-regulated
kinases (KRK1/2) and p38.



                 CMRC RESEARCH GRANT NO.           04-473
Project Title:              Hepatitis B genotypes in Saudi Arabia and its
                            effect on clinical progression of chronic hepatitis
                            B.
Principal Investigator:     Dr. Ayman A. Abdo
Department:                 Medicine
Co-investigators:           Prof. Faleh Al-Faleh, Dr. Khalid Al-Swat
Date Approved:              12.04.1425 (31.05.2004)
Project Summary:
Chronic hepatitis B is an important medical problem in Saudi Arabia.
Recently, different hepatitis B virus genotypes have been discovered and
they have been shown to cluster in different areas of the world. There are no
studies on hepatitis B genotypes in the Arab world. In addition, many


                                    63
publications have been linking different hepatitis B genotypes with different
clinical outcomes of patients with clinical chronic hepatitis B. Some of these
clinical outcomes include: chances of spontaneous sero-conversion, natural
history, risk of development of advanced fibrosis and cirrhosis, and risk of
developing hepatocellular carcinoma, and response to antiviral therapy.
In this study, we will test 80 Saudi patients infected with hepatitis B to
identify the most common genotype in Saudi Arabia. We will then try to
correlate the different hepatitis B genotypes with clinical progression of the
disease. This will be achieved by testing 20 hepatitis B carriers, 20 hepatitis
B patients with active inflammation, 20 hepatitis B patients with
                                                                        cont …




cirrhosis, and 20 hepatitis B patients with hepatocellular carcinoma.
If clear correlations are found between genotypes and clinical outcomes, this
would be very valuable information that will help guide therapy, predict
prognosis, and tailor clinical practice in patients with chronic hepatitis B
infection.




                                     64
                 CMRC RESEARCH GRANT NO.             04-474
Project Title:               Utility of measuring protein S level and reptilase
                             time in patients with liver disease.
Principal Investigator:      Dr. Ayman A. Abdo
Department:                  Medicine
Co-investigators:            Prof. Abdel Galil M.A. Gader &
                             Dr. A. Ghumlas
Date Approved:               12.04.1425 (31.05.2004)
Project Summary:
The liver plays a central role in hemostasis. In previous work, it was
suggested that the most sensitive markers of hepatocyte malfunction are total
and free protein S (PS) levels and reptilase time (RT), as these tests were
abnormal with the mildest liver affection, when other biochemical as well as
other hemostatic tests were normal. In this project, we take this finding a step
further and try to answer the question of whether measuring PS levels and
RT's is useful in managing patients with chronic liver disease.
Our main goals are (1) to compare PS levels and RT's in patients with
different stages of liver disease, (2) identify a level of PS and RT that would
be predictive of early and advanced liver dysfunction. For this reason, we
will recruit patients with various stages of liver disease including patients with
chronic hepatitis B, chronic hepatitis C, non-alcoholic fatty liver disease, and
various stages of liver cirrhosis. The level of PS and RT will also be
correlated with the histological grade of inflammation and stage of fibrosis
of liver disease on liver biopsy in hepatitis C patients, and with the Child-
Pough score in patients with cirrhosis. If these tests are shown to
                                                                          cont …



correlate well with the degree of clinical liver disease and with histology
scores, these tests may become very valuable tools to screen for early liver
dysfunction in patients with otherwise normal traditional liver function tests.




                                      65
                 CMRC RESEARCH GRANT NO.             04-475
Project Title:               Blood pressure control and salt intake in Saudi
                             diabetic hypertensive patients.
Principal Investigator:      Dr. Kerrayem Alsuwaida
Department:                  Medicine
Date Approved:               04.05.1425 (22.06.2004)
Project Summary:
The coexistence of diabetes mellitus and hypertension has devastating
consequences on the cardiovascular system. The risk of stroke or any
cardiovascular event is almost doubled at comparable blood pressure (BP)
levels when hypertensive patients have diabetes mellitus. Lowering BP
markedly decreases the rate of cardiovascular events and renal
deterioration in these patients. In fact, for every given endpoint, a reduction
in BP confers more benefit than a blood sugar reduction. To achieve the
newly recommended BP treatment goal for diabetic patients, changes have
to be made on how we approach the treatment of hypertension. A recent
study revealed that only 15% of hypertensive diabetic patients reached
goal BP, even when treated by physicians trained in hypertension
management. While there are many patient and health system related
factors that contribute to poor BP control, it is becoming increasingly
apparent that high salt intake may play significant role in diabetic
hypertensive patients. To this end, we propose a survey in type 2 diabetic
patients with uncontrolled hypertension to study salt intake in Saudi. Study
objective is to understand the impact of salt
                                                                         cont …




intake on diabetic hypertensive patients. The other objective of the study is
to assess the application of international guidelines management in diabetic
hypertensive patients and study the prevalence of masked hypertension. This
study will help us to evaluate the current health status of our patients in order
to develop a future plan for our health care system.




                                      66
                          CMRC ACHIEVEMENTS
                     POSTGRADUATE RESEARCH PROJECTS
                            APPROVED BY CMRC
                         1424-1425 A.H. (2003-2004)

 S.#              Project Title                  Ph.D.             Date
 No.                                            Student           Approved
1) PG-03-005       The effect of mild to        Dr. L. Al-Dokhi   12.01.1425
   moderate exercise on                         (Physiology)      31.05.2004
                   leptin receptor expression
                   in healthy subjects and
                   type II diabetics: A flow-
                   cytometric study.

2) PG-03-006        Nerve conduction study      Dr. F. Al-Rouq    12.04.1425
                    and FAS mediated            (Physiology)      31.05.2004
                    apoptosis in peripheral
                    neuropathy in type 2
                    diabetes.

                            -----------




                                         67
68
     SUMMARIES
          OF
   POSTGRADUATE
RESEARCH PROJECTS
      RECEIVING
    CMRC GRANT

1423 to 1425 (2002-2004)




           69
70
          POSTGRADUATE RESEARCH GRANT NO.                   03-005

Project Title:               The effect of mild to moderate exercise on leptin
                             receptor expression in healthy subjects and type
                             II diabetics: A flow-cytometric study.
Ph.D. Student:               Dr. Laila M. Al-Dokhi
Department:                  Physiology
Supervisor:                  Dr. Tariq Abdul-Rahman
Date Approved:               12.04.1425 (31.05.2004)
Project Summary:
Diabetes mellitus (DM) represents a major health problem in the Kingdom of
Saudi Arabia. Type II diabetes develops in face of a high insulin resistance
which results in defective insulin action and elevation of blood glucose.
Obesity is one of the risk factors for the development of insulin resistance and
type II diabetes mellitus. Leptin, an adipocyte-secreted hormone, has a role
in the regulation of body weight through its ability to decrease food intake
and increase energy expenditure. Type II diabetic patients showed an
increased leptin resistance. However, the association of leptin and insulin
resistance in these patients is not known. Exercise proved to improve glucose
uptake and reduce dose of insulin needed in type I DM. However, few
studies on the effect of exercise in insulin resistance in type II DM have been
reported. Therefore, our objectives are to investigate the effect of short-term
exercise on insulin and leptin resistance in type II DM. Adinopectin, another
adipocyte-secreted hormone will also be measured in

                                                                          cont …


the serum of controls and patients. Also, we need to investigate the
association of insulin and leptin resistance in these patients. This might help in
the development of therapeutic strategies to improve insulin action in type II
diabetes mellitus.




                                       71
          POSTGRADUATE RESEARCH GRANT NO.                  03-006
Project Title:               Nerve conduction study and FAS mediated
                             apoptosis in peripheral neuropathy in type 2
                             diabetes.
Ph.D. Student:               Dr. Fawzia A. Al-Rouq
Department:                  Physiology
Supervisor:                  Prof. Ashraf Hussain
Co-Supervisor:               Dr. Sitelbanat Awadalla
Date Approved:               12.04.1425 (31.05.2004)
Project Summary:
Diabetes mellitus is one of the most common chronic disorders of a modern
lifestyle. The complications of diabetes mellitus have far reaching effects on
the lives of people and also on the budget for health services. Diabetic
neuropathy (DN) is a common complication of diabetes. The prevalence of
DN in Saudi diabetic population is 82%; most of diabetic patients are of
type 2. Recently, apoptosis has been implicated in the pathogenesis of
diabetic neuropathy. The induction of apoptosis by sera from DN+ patients
may have clinical significance, as long-term exposure of nerves to serum in
vivo could contribute to the development of neuropathy. Many markers in
the serum of patients with DN which detect apoptosis. However, the
detection of early markers of apoptosis such as FAS was demonstrated in
few studies. The correlation between the nerve conduction and the level of
apoptosis markers such as FAS has not been investigated. It has been found
that antiapoptotic factors ameliorate the apoptotic changes in many cell
lines. However, the application
                                                                       cont…


of the anti-apoptotic factors in neuronal cell lines exposed to sera of diabetic
neuropathy patients have not yet been demonstrated.
Therefore, our objectives are to detect early marker(s) of apoptosis and to
correlate the level of soluble Fas in the serum of diabetic patients with the
clinical and electrophysiological findings of neuropathy. Also to investigate
the role of antiapoptopic factors in diabetic neuropathy. This might have
future implication in prevention and/or treatment of diabetic neuropathy.




                                      72
        BRIEF REPORT OF

EXPERIMENTAL RESEARCH CONDUCTED

              at the

CENTER FOR LABORATORY ANIMALS &

  EXPERIMENTAL SURGERY (CLAES)

      COLLEGE OF MEDICINE

        RESEARCH CENTER

            (C.M.R.C.)




                73
74
Title: "Evaluating immediate implant with or without bone
       grafts, histomorphometric and histological study in
       experimental animals"




Investigator   : Asala Al-Sulaimani

Department     : College of Dentistry

Duration       : 6 months

Date           : 30/01/1423-H

Types of animals used:    Beagle dogs

Number of animals used: 8 dogs

Purpose        : Thesis for Master Degree




                              75
Title: "The effect of olive oil with different qualities on
       plasma and liver lipids in rats"




Investigator   : Al-Ghoura Abudalla Al-Ashree

Department     : College of Agriculture, Department of Food
                 Science and Nutrition

Duration       : 6 months

Date           : Year 1423-H

Types of animals used:   Rats

Number of animals used: 50 rats

Purpose        : Thesis for Master Degree in Human Nutrition




                                76
Title: "The role of leptin in formation of bone in the
       overectomized diabetic rats"




Investigator   : Dr. Heyam Ibraheem Gad

Department     : College of Medicine, Physiology Department

Duration       : 6 months

Date           : Year 1425-H

Types of animals used:   Rats

Number of animals used: 90 rats

Purpose        : Experimental work




                                77
Title: "Effect of soaking, germination and cooking on some
       anti-nutritional factors and nutritional value of
       Securigera securidaeceia seeds"




Investigator   : Marum Hassan Al-Sihebanee

Department     : College of Agriculture, Department of Food
                 Science and Nutrition

Duration       : 3 months

Date           : 03/1425-H

Types of animals used:   Rats

Number of animals used: 48 rats

Purpose        : Thesis for Master Degree in Human Nutrition




                                78
Title: "Some nutritional characteristics of tomato seeds"




Investigator   : Dr. Tahnee Ali Al-Gerboh

Department     : College of Agriculture, Department of Food
                 Science and Nutrition

Duration       : 6 weeks

Date           : 04/1425-H

Types of animals used:     Albino rats

Number of animals used: 60 rats

Purpose        : Thesis for Master Degree in Human Nutrition




                               79
Title: "Assessment of myrrh effect on intra-oral mucosal
       wound healing as compared to tetracycline mouth "




Investigator   : Dr. Azizah Al-Mobeireeek (BDS, M.Sc.)

Department     : College of Dentristry

Duration       :

Date           :

Types of animals used:    Wister rats

Number of animals used: 150 male rats

Purpose        : Experimental work for research project




                              80
Title: "Study of angiotensin after               administration   of
       angiogenic growth factors"




Investigators   : Dr. Hussein Al-Rabee, Dr. Tufeeque, Dr. Eman

Department      : College of         Medicine,    Vascular   Surgery
                  Department

Duration        : 6 months

Date            : Year 1425-H

Types of animals used:    Rabbits

Number of animals used: 20 rabbits

Purpose         : Experimental work for research project; still
                  ongoing.




                                81
Title: "Effect of some antioxidants on zinc and copper
       levels in rats"




Investigator   : Manal Khalid Afnan

Department     : College of Education, Department of Nutrition

Duration       : 6 months

Date           : Year 1425-H

Types of animals used:   Rats (SD)

Number of animals used: 95 female rats

Purpose        : Thesis for Ph.D. degree




                               82
Title: "In vitro and in vivo evaluation of gatifloxacin
       biodegradable    implants   for  treatment    of
       experimental osteomyelitis"




Investigator   : Dr. Amal Hassan El-Kamel
                 Dr. Manal Mohd. Baddour

Department     : College of Pharmacy (Girl's College), KSU

Duration       :

Date           : Year 1425-H

Types of animals used:    Rabbits

Number of animals used: 50 rabbits

Purpose        : Research work; still ongoing




                               83
84
  STAFF PUBLICATIONS
      ABSTRACTS
          &
    PRESENTATIONS


1422-1424 A.H. (2002-2004)




            85
86
  DEPARTMENT OF ANATOMY




Chairman: Dr. Musaad A. Al-Fayez, MSc, PhD
          Assistant Professor of Anatomy

Address:   Department of Anatomy (#28)
           College of Medicine
           King Saud University
           P.O. Box 2925, Riyadh 11461
           Kingdom of Saudi Arabia
Phone:     4670809
               Fax:   4671300




                      87
DEPARTMENT OF ANATOMY




         88
DEPARTMENT OF ANESTHESIA




Chairman:   Abdulhamid H. Samarkandi, FRARCSI
            Associate Professor of Anesthesia

Address:    Department of Anesthesia (#41)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4670893, 4671597
Fax:        4679364




                   89
            DEPARTMENT OF ANESTHESIA

1.   Abdel Aziz A, Bakir MB, Al-Satli RA, Samarkandi AH, Fouda M.
     Intraoperative evaluation of graft patency in off-pump coronary
     artery bypass grafting. J Saudi Heart Assoc 2003; 15(1):8-12.

2.   Al-Mobeireek AF, Almutawa J, Al-Satli RA. The nineteenth
     pregnancy in a patient with cor pulmonale and severe pulmonary
     hypertension: A management challenge. Acta Obstet Gynecol
     Scand 2003; 82(7):676-678.

3.   Bakir MB, Abdel Aziz A, Al-Satli RA, Samah A, Al-Saddique A,
     Fouda M. Hemodynamic changes in off pump coronary artery
     bypass (OPCAB). J Egypt Soc Cardiothorac Surg 2002; vol. X(2):
     191-200.

4.   El-Dawlatly AA. Blood biochemistry following endoscopic third
     ventriculostomy. Minim Invasive Neurosurg 2004; 47(1):47-48.

5.   El-Dawlatly AA. EEG bispectral index during carotid
     endarterectomy. Middle East J Anesthesiol 2003; 17(2):287-293.

6.   El-Dawlatly AA, Al-Dohayan A, Abdel-Maguid ME, El-Bakry A,
     Manaa EM. The effects of pneumoperitoneum on respiratory
     mechanics during general anesthesia for bariatric surgery. Obes
     Surg 2004; 14(2):212-215.

7.   El-Dawlatly AA, Al-Dohayan A, Abdel-Maguid ME, Turkistani A,
     Alotaiby WM, Abdelaziz EM.           Variations in dynamic lung
     compliance during endoscopic thoracic sympathectomy with CO2
     insufflation. Clin Auton Res 2003; 13(1):194-197.

8.   El-Dawlatly AA, Al-Dohayan A, Riyad W, Thalaj A, Delvi B, Al-Saud
     S. Thoracoscopic sympathectomy: endobronchial anesthesia vs
     endotracheal anesthesia with intrathoracic CO2 insufflation. J
     Anesth 2002; 16(1):13-16.




                                 90
9.    El-Dawlatly AA, Al-Kattan K, Hajjar W, Medany Y, El-Bakry A.
      Anesthetic   considerations    on    bronchocarinal    resection
      anastomosis. The Internet Journal of Anesthesiology 2003; vol. 6,
      no. 2.

10.   Naguib M, Samarkandi A, Riad W, Alharby SW. Optimal dose of
      succinylcholine revisited. Anesthesiology 2003; 99(5):1045-1049.

11.   Takrouri MS. New concepts in intensive care: dexmedetomidine
      and immunonutrition. Middle East J Anesthesiol 2002; 16(6):567-
      572.

12.   Takrouri MS, Khalaf M. Ibn al-Nafis contribution to science. Middle
      East J Anesthesiol 2003; 17(2):163-176.




                                   91
92
DEPARTMENT OF BIOCHEMISTRY




Chairman:   Mohsen A.F. El-Hazmi, Ph.D., FRCPath.
            Professor & Consultant
            of Medical Biochemistry

 Address:   Department of Biochemistry (#30)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
 Phone:     4670830, 4671321
 Fax:       4672575




                      93
          DEPARTMENT OF BIOCHEMISTRY

1.   El-Hazmi MA, Warsy AS. Increased frequency of angiotensin-
     converting enzyme DD genotype in Saudi overweight and obese
     patients. Ann Saudi Med 2003; 23(1-2):24-27.

2.   El-Hazmi MA. Ethics of genetic counseling – Basic concepts and
     relevance to Islamic communities. Review article. Ann Saudi Med
     2004; 24(2):84-92.

3.   Babay ZA, Warsy AS, El-Hazmi MF, Addar MH. Leptin level in
     pregnant mothers at term and cord blood and the effect of
     newborns gender. Saudi Med J 2004; 25(2):212-214.




                                94
DEPARTMENT OF DERMATOLOGY




  Chairman:   Marwan M. Al-Khawajah, FACHARZT
              Professor of Medicine
              Consultant Dermatologist

  Address:    Department of Dermatology
              College of Medicine (#82)
              King Saud University
              P.O. Box 2925, Riyadh 11461
              Kingdom of Saudi Arabia
  Phone:      4671938
  Fax:        4679444




                    95
          DEPARTMENT OF DERMATOLOGY

1.   Al-Hoqail IA. Knowledge, beliefs and perception of youth toward
     acne vulgaris. Saudi Med J 2003; 24(7):765-768.

2.   Al-Suwaidan SN, Eichenfield LF. Port Wine Stain. In: Lebwohl M,
     Heymann WR, Berth-Jones J, Coulson I, editors. Treatment of
     Skin Diseases: comprehensive therapeutic strategies. London:
     Mosby 2002, pp 496-498.

3.   Bernard LA, Cunningham BB, Al-Suwaidan SN, Friedlander SF,
     Eichenfield LF. A rosacea-like granulomatous eruption in a patient
     using tacrolimus ointment for atopic dermatitis. Arch Dermatol
     2003; 139(2):229-231.

4.   Wilson JK, Al-Suwaidan SN, Krowchuk D, Feldman SR. Treatment
     of psoriasis in children: is there a role for antibiotic therapy and
     tonsillectomy? Pediatr Dermatol 2003; 20(1):11-15. Review.


ABSTRACTS AND PRESENTATIONS
1.   Al-Suwaidan SN. Lasers in darkly pigmented skin: Highlights and
     perspectives.   Dermatology 2003 International Symposium,
     Jeddah, Saudi Arabia, 25-26 June 2003.




                                  96
    DEPARTMENT OF E.N.T.




Chairman:   Surayie Hamad Al-Dousary, M.D.
            Associate Professor
            Consultant Otorhinolaryngologist

Address:    Department of E.N.T. (#33)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4786100 ext. 2296
Fax:        4785748




                    97
                 DEPARTMENT OF E.N.T.

1.   Abu El-Asrar AM, Jesteneiah S, Al-Serhani AM. Regression of
     aneurysmal dilatations in a case of idiopathic retinal vasculitis,
     aneurysms and neuroretinitis (IRVAN) associated with allergic
     fungal sinusitis. Eye 2004; 18(2):197-199.

2.   Al-Ammar AY. Otolaryngologic manifestation of gastro-esophageal
     reflux in children. Saudi Med J 2003; 24(1):62-67.

3.   Al-Mazrou KA, Alorainy IA, Al-Dousary SH, Richardson MA. Facial
     nerve anomalies in association with congenital hearing loss. Int J
     Pediatr Otorhinolaryngol 2003; 67(12):1347-1353.




                                 98
           DEPARTMENT OF FAMILY &
            COMMUNITY MEDICINE




Chairman: Eiad Abdel Mohsin El-Faris, MRCGP
          Professor of Family & Community Medicine

Address:    Dept. of Family & Community Medicine (#34)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4670836
Fax:        4671967




                          99
     DEPT. OF FAMILY & COMMUNITY MEDICINE

1.   Al-Ansary LA, Khoja TA. The place of evidence-based medicine
     among primary health care physicians in Riyadh region, Saudi
     Arabia. Fam Pract 2002; 19(5):537-542.

2.   Al-Arfaj AS, Alballa SR, Al-Dalaan AN, Al-Saleh SS, Al-Sekeit MA,
     Bahabri M, Mousa A. Musculoskeletal pain in the community.
     Saudi Med J 2003; 24(8):863-867.

3.   Al-Arfaj AS, Alballa SR, Al-Saleh SS, Al-Dalaan AN, Bahabri SA,
     Mousa MA, Al-Sekeit MA. Knee osteoarthritis in Al-Qaseem, Saudi
     Arabia. Saudi Med J 2003; 24(3):291-293.

4.   Al-Arfaj AS, Alballa SR, Al-Sekeit MA, Al-Saleh SS, Al-Dalaan AN,
     Bahabri SA, Mousa MA. Mouth and genital ulcerations in the
     community. Saudi Med J 2003; 24(1):76-78.

5.   Al-Arfaj AS, Al-Saleh SS, Alballa SR, Al-Dalaan AN, Bahabri SA,
     Al-Sekeit MA, Mousa MA. How common is back pain in Al-
     Qaseem region. Saudi Med J 2003; 24(2):170-173.

6.   Al-Faris EA. The diabetic patient and fasting Ramadan. In: Babelli
     DM (ed), Facts About Diabetes Mellitus, Al-Obeikan Bookshop.
     [Book Chapter].

7.   Al-Faris EA. The diabetic patient and Haj. In: Babelli DM (ed),
     Facts About Diabetes Mellitus, Al-Obeikan Bookshop. [Book
     Chapter].

8.   Al-Momen RK, Al-Rowais NA. Arabic translation of the book "The
     Doctors Communication Handbook" by Peter Tate, Radcliffe
     Medical Press Ltd., 2003; in press.

9.   Al-Momen RK, El-Jack I, Al-Nowaiser NA, Al-Rowais NA. A
     scoring system as a tool for antenatal care audit in family
     medicine. Saudi Med J 2003; 24(1):40-43.



                                 100
10.   Al-Nahedh N. Socio-demographic characteristics of breast feeding
      mothers in Riyadh, Saudi Arabia.     Emirates Med J 2002;
      20(3):343-346.

11.   Al-Rowais NA, Al-Shobaili RM.         Patient satisfaction with
      consultation in Primary Health Care setting in Riyadh, Saudi
      Arabia. Emirates Med J 2002; 20(3):353-357.

12.   Al-Rukban MO. Obesity among Saudi male adolescents in
      Riyadh, Saudi Arabia. Saudi Med J 2003; 24(1):27-33.

13.   Azeri A, Ashoor B, Al-Tahami, Gad A, Al-Rabeah A, Al-Hamdan N,
      Al-Jeffri M, et al. Meningococcal carriage among Hajjees in
      Makkah 1421H. Saudi Epidemiol Bull 2002; 9(1):3-4.

14.   Bamgboye EA, Al-Nahedh N. Factors associated with growth
      faltering in children from rural Saudi Arabia. Afr J Med Med Sci
      2003; 32(4):434-347.

15.   Becker S, Al-Zaid K, Al-Faris EA. Screening for somatization and
      depression in Saudi Arabia: a validation study of the PHQ in
      primary care. Int J Psychiatry Med 2002; 32(3):271-283.

16.   Gad A. A survey of mid-season soccer related injuries among
      Saudi football players. Saudi J Sports Med 2002; 6(2):73-76.

17.   Gad A. Work-related assaults on nursing staff in Riyadh, Saudi
      Arabia. J Fam Commun Med 2002; 3(9):51-55.

18.   Kalantan K, Pyrne N, Al-Faris E, Al-Taweel A, Al-Rowais N, Abdul
      Ghani H, Eldin Magzoub M. Student's perception towards a family
      medicine attachment experience. Educ Health (Abingdon) 2003;
      16(3):357-365.

19.   Kalantan KA, Al-Taweel AA, Al-Faris EA. Pattern of intestinal
      parasitic infection among food handlers in Riyadh, Saudi Arabia. J
      Fam Commun Med 2002.




                                  101
ABSTRACTS AND PRESENTATIONS

1.   Al-Quaiz J. What do family physician trainees think about the
     structure of hospital vocational training? A qualitative study. New
     Dimensions for Medical Education in Family and Community
     Medicine. The Saudi Society of Family and Community Medicine,
     Riyadh, Saudi Arabia, October 2003.




                                 102
 DEPARTMENT OF MEDICINE




Chairman: Jamal Saleh Al-Wakeel, FRCP(C)
          Professor of Medicine &
          Consultant Nephrologist

Address:   Department of Medicine (#38)
           College of Medicine
           King Saud University
           P.O. Box 2925, Riyadh 11461
           Kingdom of Saudi Arabia
Phone:     4670897
Fax:       4672558




                     103
               DEPARTMENT OF MEDICINE

1.    Abba AA. Asymptomatic full term pregnant patient with a grossly
      abnormal chest radiograph. Saudi Med J 2003; 24(6):677-679.

2.    Abba AA, Al-Harthy MS. Wandering spleen. Saudi Med J 2003,
      24(12):1404-1405.

3.    Abba AA, Al-Mobeireek AF. Clinical spectrum of Swyer-James-
      Macleod syndrome in adults. Saudi Med J 2003; 24(2):195-198.

4.    Abba AA, Bamgboye EA. Predicting nodal malignancy from
      clinical data. Saudi Med J 2003; 24(7):769-773.

5.    Abba AA, Wani BA, Rahmatullah RA, Khalil MZ, Kumo AM,
      Ghonaim MA. Door to needle time in administering thrombolytic
      therapy for acute myocardial infarction. Saudi Med J 2003;
      24(4):361-364.

6.    Abdel-Halim RE, Al-Tuwaijri AS, El-Faqih SR, Mitwalli AH.
      Extraction of urinary bladder stone as described by Abul-Qasim
      Khalaf Ibn Abbas Alzahrawi (Albucasis) (325-404 H, 930-1013
      AD). A translation of original text and a commentary. Saudi Med J
      2003; 24(12):1283-1291.

7.    Abdo A, Klassen J, Urbanski S, Raber E, Swain MG. Reversible
      sclerosing cholangitis secondary to cryptosporidiosis in a renal
      transplant patient. J Hepatol 2003; 38(5):688.691.

8.    Abdo A, Meddings J, Swain M. Liver abnormalities in celiac
      disease. Clin Gastroenterol Hepatol 2004; 2(2):107-112.

9.    Abdo AA, Bain VG, Kichian K, Lee SS. Evolution of autoimmune
      hepatitis to primary sclerosing cholangitis: A sequential syndrome.
      Hepatology 2002; 36(6):1393-1399.

10.   Abdo AA, Beck P. Diagnosis and management of microscopic
      colitis. Can Fam Physician 2003; 49:1473-1478. Review.


                                  104
11.   Abdo AA, Codere S, Bridges RJ. Leptomeningeal carcinomatosis
      secondary to gastroesophageal adenocarcinoma: a case report
      and review of the literature. Can J Gastroenterol 2002; 807-811;
      quiz 831-831.

12.   Abdo AA. Urbanski SJ, Beck PL. Lymphocytic and collagenous
      colitis: the emerging entity of microscopic colitis. An update on
      pathophysiology, diagnosis and management.                Can J
      Gastroenterol 2003; 17(7):425-432.

13.   Abou El-Ella KM, Mohamed ON, Al-Sebayel MI, Al-Smayer SA, Al-
      Mofleh IA. Management of post-laparoscopic cholecystectomy
      major bile duct injury: comparison of MRCP with conventional
      methods. Saudi J Gastroenterol 2004; 10(1): 8-15.

14.   Abu-Aisha H, Mitwalli A, Huraib SO, Al-Wakeel J, Abid J, Yousif KI,
      Algayyar F, Ramia S. The effect of chemical and heat disinfection
      of the hemodialysis on the spread of hepatitis C virus: a
      prospective study. Saudi Med J 2003; 24 Suppl 2:S123.

15.   Al-Akwaaa, Siddiqui N, Al-Mofleh IA. Primary gastric lymphoma.
      World J Gastroenterol 2004; 10(1):5-11.

16.   Al-Amri SM. The pattern of esophageal manometry in progressive
      systemic sclerosis. Saudi Med J 2003; 24(1):68-71.

17.   Al-Arfaj AS. Radiographic osteoarthritis and serum cholesterol.
      Saudi Med J 2003; 24(7):745-747.

18.   Al-Arfaj AS. Radiographic osteoarthritis and serum triglycerides.
      Bahrain Med Bull 2003; 25(2):77-79.

19.   Al-Arfaj AS. Serum uric acid and radiographic osteoarthritis. J
      Pakistan Med Assoc (JPMA) 2003; 53(5):187-189.

20.   Al-Arfaj AS, Alballa SR, Al-Dalaan AN, Al-Saleh SS, Al-Sekeit MA,
      Bahabri M, Mousa A. Musculoskeletal pain in the community.
      Saudi Med J 2003; 24(8):863-867.



                                  105
21.   Al-Arfaj AS, Alballa SR, Al-Saleh SS, Al-Dalaan AN, Bahabri SA,
      Mousa MA, Al-Sekeit MA. Knee osteoarthritis in Al-Qaseem,
      Saudi Arabia. Saudi Med J 2003; 24(3):291-293.

22.   Al-Arfaj AS, Alballa SR, Al-Sekeit MA, Al-Saleh SS, Al-Dalaan AN,
      Bahabri SA, Mousa MA. Mouth and genital ulcerations in the
      community. Saudi Med J 2003; 24(1):76-78.

23.   Al-Arfaj AS, Alballa SR, Mustafa AA, Al-Tuwaijri AS, Al-Humayyd
      MS, Al-Dalaan AN. Effect of diclofenac alone or in combination
      with    alpha-tocopherol   on     the   oxidative    activity of
      polymorphonuclear leukocytes in healthy and osteoarthritic
      individuals. Saudi Med J 2004; 25(2):198-203.

24.   Al-Arfaj AS, Al-Saleh SS, Alballa SR, Al-Dalaan AN, Bahabri SA,
      Al-Sekeit MA, Mousa MA. How common is back pain in Al-
      Qaseem region. Saudi Med J 2003; 24(2):170-173.

25.   Al-Arfaj AS, Mustafa AA, Alballa SR, Al-Tuwaijri AS, Al-Dalaan AN.
      Interaction of allopurinol and non-steroidal anti-inflammatory drugs
      on the carrageen-induced rat paw edema. Saudi Med J 2003;
      24(9):936-940.

26.   Al-Boukai AA, Al-Arfaj AS. Rheumatoid arthritis. Radiological
      changes in the cervical spine. Saudi Med J 2003; 24(4):396-399.

27.   Al-Diab AI. Comparative efficacy of various therapies for the
      management of adult Hodgkin's disease. Emirates Med J 2004;
      22(1):63-70.

28.   Al-Diab AI, Siddiqui N, Sogiawalla FF, Fawzy EM. The changing
      trends of adult Hodgkin‟s disease in Saudi Arabia. Saudi Med J
      2003; 24(6): 617-622.

29.   Al-Faleh FZ. Changing pattern of hepatitis viral infection in Saudi
      Arabia in the last two decades. Ann Saudi Med 2003; 23(6):367-
      371.




                                   106
30.   Al-Hamad AM. A prospective analysis of cardiology psychiatric
      consultations over three years. J Saudi Heart Assoc 2004;
      16(2):106-111.

31.   Al-Hamad AM.        Pattern of gastroenterology psychiatric
      consultations.   A prospective study. Saudi Med J 2004;
      25(9):1284-1286.

32.   Al-Hamad AM. Physical injuries caused by traditional healers: a
      report of two psychiatric cases. Ann Saudi Med 2003; 23(5):289-
      290.

33.   Al-Hazzaa HA, Al-Mobeireek AF, Al-Howaikan AM.         Cardio-
      pulmonary exercise testing. An underutilized diagnostic tool in
      Saudi Arabia. Saudi Med J 2004; 25(10):1453-1458.

34.   Al-Jumah M, Majumdar R, Al-Rajeh S, Awada A, Al-Zaben A, Al-
      Traif I, Al-Jumah AR, Rehana Z. A clinical and genetic study of 56
      Saudi Wilson's disease patients: identification of Saudi-specific
      mutations. Eur J Neurol 2004; 11(2):121-124.

35.   Al-Jumah M, Majumdar R, Al-Rajeh S, Chaves-Carbello E, Salih
      M, Al-Shahwan S, Al-Bubiey K, Al-Uthaim S. Molecular analysis of
      the spinal muscular atrophy and neuronal apoptosis inhibitory
      protein genes in Saudi patients with spinal muscular atrophy.
      Saudi Med J 2003; 24(10):1052-1054.

36.   Al-Kheir A, Al-Mobeireek AF, Al-Tahan A, Alasali K. Shrinking lung
      syndrome in systemic lupus erythematosus. Bahrain Med J 2003;
      25(1):50-51.

37.   Al-Maatouq MA, El-Desouki MI, Othman SA, Mattar EH, Babay ZA,
      Addar M. Prevalence of osteoporosis among postmenopausal
      females with diabetes mellitus. Saudi Med J 2004; 25(9):1423-
      1427.

38.   Al-Meshari AA, Gader AM, Al-Jabbari AW, Al-Momen AK, Gad El-
      Rab MO, Babay ZH, Mahmoud N. The prevalence of lupus
      anticoagulant in normal pregnancy and in women with recurrent


                                  107
      fetal loss – recommendations of laboratory testing for lupus
      anticoagulant. Ann Saudi Med 2004; 24(6):429-433.

39.   Al-Mobeireek AF. The efficacy of a management protocol in
      reducing emergency visits and hospitalizations in chronic
      asthmatics. (Letter) Saudi Med J 2003; 24(6):694.

40.   Al-Mobeireek A, Alamoudi O.           Allergic bronchopulmonary
      aspergillosis mimicking pulmonary tuberculosis. Saudi Med J 2002;
      23(4):476.

41.   Al-Mobeireek A, Alamoudi O. The efficacy of a management
      protocol in reducing emergency visits and hospitalization in chronic
      asthmatics. [Letter] Saudi Med J 2003; 24(6):694-695.

42.   Al-Mobeireek A, Dashash NA. Prescribing for asthmatic children in
      primary care. [Letter] Saudi Med J 2003; 24(11):1274.

43.   Al-Mobeireek AF, Almutawa J, Al-Satli RA. The nineteenth
      pregnancy in a patient with cor pulmonale and severe pulmonary
      hypertension: A management challenge. Acta Obstet Gynecol
      Scand 2003; 82(7):676-678.

44.   Al-Mobeireek AF, Saleemi SA.            Facing the severe acute
      respiratory syndrome (SARS) epidemic. Hope for the best and
      prepare for the worst. [Editorial]. Saudi Med J 2003; 24(4):E1.

45.   Al-Mofarreh MA, Al-Akwaa' AM, Al-Mofleh IA. Gammaglutamyl
      transpeptidase activity in patients with schistosomiasis. Saudi J
      Gastroenterol 2003; 9(1):15-19.

46.   Al-Mofleh IA, Aljebreen AM, Al-Amri SM, Al-Rashed RS, Al-Faleh
      FZ, Al-Freihi HM, Abdo AA, Isnani AC.            Biochemical and
      radiological predictors of malignant biliary strictures. World J
      Gastroenterol 2004; 10(10):1504-1507.

47.   Al-Mofleh IA, Al-Rashed RS, Al-Amri SM, Al-Ghamdi AS, Al-Faleh
      FZ, Al-Freihi HM, Isnani AC. Malignant biliary strictures. Diagnosis
      and management. Saudi Med J 2003; 24(12):1360-1363.


                                   108
48.   Al-Mubarak HF, Husain SA. Tracheobronchomegaly-Mounier-
      Kuhn syndrome. Saudi Med J 2004; 25(6):798-801.

49.   Al-Nozha MM, Al-Daghri N, Bartlett WA, Al-Attas O, Al-Maatouq M,
      Martin SC, Kumar S, Jones AF.               Serum homocysteine
      concentration is related to diabetes mellitus, but not to coronary
      heart disease in Saudi Arabians. Diabetes Obes Metab 2002;
      4(2):118-123.

50.   Al-Nozha MM, Arafah MR, Al-Mazrou YY, Al-Maatouq MA, Khan
      NB, Khalil MZ, Al-Khadra AH, Al-Marzouki K, Abdullah MA, Al-
      Harthi SS, Al-Shahid MS, Nouh MS, Al-Mobireek A. Coronary
      artery disease in Saudi Arabia. Saudi Med J 2004; 25(9):1165-
      1171.

51.   Al-Nozha MM, Khalil MZ, Al-Mofleh IA, Al-Ghamdi AS. Lack of
      association of coronary artery disease with H. pylori infection.
      Saudi Med J 2003; 24(12):1370-1373.

52.   Al-Saghir AH, Al-Mobeireek AF. Bronchiolitis obliterans organizing
      pneumonia. Saudi Med J 2004; 25(5):557-565.

53.   Al-Shamairi MQ, Al-Nozha MM.      Peripartum cardiomyopathy
      searching for a better understanding.   Saudi Med J 2003;
      24(10):1048-1051.

54.   Alsuwaida K. Primary cutaneous mucormycosis complicating the
      use of adhesive tape to secure the endotracheal tube. Can J
      Anaesth 2002; 49(8):880-882.

55.   Al-Zayed AH, Jammah AA, Al-Nozha MM. Physical assaults on a
      medical resident. Saudi Med J 2003; 24(8):895-897.

56.   Alzeer AH, Al-Arfaj A, Basha S, Alballa S, Al-Wakeel J, Al-Arfaj H,
      Al-Sugair S, Al-Mugeiren S, Al-Shamairi M, Bamgboye EA.
      Outcome of patients with systemic lupus erythematosus in
      intensive care unit. Lupus 2004; 13:537-542.




                                  109
57.   Arafah MR. Acute and late major adverse cardiac events using the
      S7 coronary stent. J Saudi Heart Assoc 2004; 16(2):117-121.

58.   Bahammam A. Effects of fasting during Ramadan on sleep
      architecture, daytime sleepiness and sleep pattern. Sleep and
      Biological Ryhthms 2004; 2:135-143.

59.   Daif AK.   Multiple sclerosis: recent modalities of treatment.
      Neuroscience J 2003; accepted.

60.   El-Badawy RM, Al-Ghamdi AS, Al-Mofleh IA. Concepts in leptin
      and liver disease. Saudi J Gastroenterol 2004; 10(2):57-66.

61.   El-Desouki MI, Othman SM, Fouda MA. Bone mineral density and
      bone scintigraphy in adult Saudi female patients with
      osteomalacia. Saudi Med J 2004; 25(3):355-358.

62.   El-Mouzan MI, Al-Mofleh IA, Abdullah AM, Al-Rashed AR.
      Indications and yield of upper gastrointestinal endoscopy in
      children. Saudi Med J 2004; 25(9):1223-1225.

63.   Khalil MZ. Diagnosis of regional enteritis (Crohn Disease). Saudi
      J Gastroenterol 2003; 9(1):6-10.

64.   Khalil MZ, Abba AA. Management of acute myocardial infarction.
      Do we follow guidelines applied in practice? Saudi Med J 2003;
      24(11):1234-1237.

65.   Khalil MZ, Al-Nozha MM, Wani BA.            Asymptomatic giant
      pulmonary artery aneurysm in an elderly male patient. Saudi Med
      J 2004; 25(6):802-804.

66.   Lee SS, Abdo AA. Predicting antiviral treatment response in
      chronic hepatitis C: how accurate and how soon? J Antimicrob
      Chemother 2003; 51(3):487-491.

67.   Matar KM, Mayet AY, Ayoola EA, Bawazir SA, Al-Faleh FZ, Al-
      Wazzan A. Isoniazid acetylation phenotyping in Saudi Arabs. J
      Clin Pharm Ther 2004; 29(5):443-447.


                                 110
68.   Qureshi NA, Al-Habeeb TA. Making gynecological and psychiatric
      sense out of premenstrual pains, tension and dysphoria. Saudi
      Med J 2004; 25(6):717-727.

69.   Shah A, Alamoudi O, Al-Mobeireek AF.                    Allergic
      bronchopulmonary aspergillosis: A view from India. Saudi Med J
      2002; 23(12):1559-1561.

70.   Shobokshi OA, Serebour FE, Al-Drees AZ, Mitwalli AH, Qahtani A,
      Skakni L. Hepatitis C virus seroprevalence rate among Saudis.
      Saudi Med J 2003; 24(Suppl 2):S81-86.

71.   Siddiqui N, Al-Diab AI. Intrapericardial chemotherapy for the
      management of neoplastic cardiac tamponade. Saudi Med J 2003;
      24(5):526-528.

72.   Tarif N, Azam MN. Radiocontrast induced nephropathy. [Editorial]
      J Saudi Heart Assoc 2004; 16(1):1-7.

73.   Tarif N. Candida lusitaniae peritonitis in a chronic ambulatory
      peritoneal dialysis patient. Saudi J Kidney Dis Transplant 2004;
      15(2):170-173.

74.   Zaidan R, Al-Moallem M, Al-Wani B, Shamena AR, Al-Tahan AR,
      Daif AK, Al-Rajeh S.         Thrombosis complicating high dose
      intravenous immunoglobulin: report of three cases and review of
      the literature. Eur J Neurol 2003; 10(4):367-372.


ABSTRACTS AND PRESENTATIONS

1.    Abu-Aisha H, Mitwalli AH, Huraib SO, Al-Wakeel JS, Abid J, Yousif
      KI, Algayyar F, Ramia S. The effect of chemical and heat
      disinfection of the hemodialysis on the spread of hepatitis C virus:
      a prospective study. [Abstract] Saudi Med J 2003; 24 (Suppl
      2):S123.

2.    Al-Faleh FZ. Changing epidemiology of hepatitis A, B and C in
      Saudi Arabia. The 2nd International Symposium on Pediatric


                                   111
     Gastroenterology, Hepatology and Nutrition, King Faisal Specialist
     Hospital & Research Center, Riyadh, 13-15 January 2003.

3.   Arafah M. Mitral balloon valvuloplasty during pregnancy: long term
     follow up. 14th Scientific Session of the Saudi Heart Association,
     Al-Khobar, 21-22 January 2003.

4.   Arafah M. The Med. Stent Registry: Multi and late major cardiac
     events. 14th Scientific Session of the Saudi Heart Association, Al-
     Khobar, 21-22 January 2003.

5.   Ballow AA, Huraib S, Gader AM, Mitwalli A, Al-Wakeel J.
     Haemostatic activation markers in patients with chronic renal
     failure.   4th International Symposium of Hematology and
     Transfusion Medicine, 5-8 October 2002, Riyadh, Saudi Arabia.

6.   Gader AM, Bayoumy NM, Al-Momen AK. A 14 years audit on the
     use of blood components at King Khalid University Hospital
     (KKUH), Riyadh. 27th Congress of the International Society of
     Blood Transfusion (ISBT), 24-28 August 2002, Vancouver, BC.
     Abstract published in Vox Sanguinis 2002; 83(suppl 2):200.

7.   Osman AK, Al-Nozha MM. Prevalence of obesity in childhood in
     Saudi Arabia. The 2nd International Symposium on Pediatric
     Gastroenterology, Hepatology and Nutrition, King Faisal Specialist
     Hospital & Research Center, Riyadh, 13-15 January 2003.




                                  112
DEPARTMENT OF OBSTETRICS &
      GYNECOLOGY



Chairman:   Mohammed H. Addar, A.B.
            Associate Professor
            Consultant Obstetrician & Gynecologist

Address:    Dept of Obstetrics & Gynecology (#36)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4670818
Fax:        4679347




                      113
DEPARTMENT OF OBSTETRICS & GYNECOLOGY

1.   Abdulwahab AA, Hassan S, Al-Nuaim LA, Abdel Halim R. Pelvic
     hematoma resulting in obstructive uropathy. Saudi Med J 2003;
     24(11):1254-1255.

2.   Al-Hakeem M, Siddiq MM, Al-Nuaim LA, Ghourab S. Unicornuate
     uterus with a non-communicating functioning rudimentary horn,
     associated with ipsilateral renal agenesis. Ann Saudi Med 2004;
     24(1):48-49.

3.   Al-Maatouq MA, El-Desouki MI, Othman SA, Mattar EH, Babay ZA,
     Addar M. Prevalence of osteoporosis among postmenopausal
     females with diabetes mellitus. Saudi Med J 2004; 25(10):1423-
     1427.

4.   Al-Mobeireek AF, Almutawa J, Al-Satli RA. The nineteenth
     pregnancy in a patient with cor pulmonale and severe pulmonary
     hypertension: A management challenge. Acta Obstet Gynecol
     Scand 2003; 82(7):676-678.

5.   Al-Nuaim LA. Views of women towards cesarean section. Saudi
     Med J 2004, 25(6):707.710.

6.   Babay ZA. Proximal femoral focal deficiency in a newborn. Ann
     Saudi Med 2004; 24(6):482-483.

7.   Babay ZA, Addar MH, Shahid K, Meriki N. Age at menarche and
     the reproductive performance of Saudi women. Ann Saudi Med
     2004; 24(5):354-356.

8.   Babay ZA, Warsy AS, El-Hazmi MF, Addar MH. Leptin level in
     pregnant mothers at term and cord blood and the effect of
     newborns gender. Saudi Med J 2004; 25(2):212-214.

9.   Faiz SA, Al-Meshari AA, Sporrong BG. Pregnancy and valvular
     heart disease. Saudi Med J 2003; 24(10):1098-1101.



                               114
10.   Faiz SA, Habib FA, Sporrong BG, Khalil NA. Results of delivery in
      umbilical cord prolapse. Saudi Med J 2003; 24(7):754-757.

11.   Faiz SA, Nainar SI, Addar MH. Herpes gestationis. Saudi Med J
      2004; 25(6):792-794.

12.   Faiz SA, Sporrong BG, Al-Meshari AA. A case of seven recurrent
      ectopic pregnancies. Saudi Med J 2003; 24(5):529-531.

13.   Khashoggi TY. Higher order multiple repeat cesarean sections:
      maternal and fetal outcome. Ann Saudi Med J 2003; 23(5):278-
      282.

14.   Khashoggi TY. Prevalence of gestational trophoblastic disease. A
      single institution experience. Saudi Med J 2003; 24(12):1329-
      1333.

15.   Kurdi AM, Mesleh RA, Al-Hakeem MM, Khashoggi TY, Khalifa HM.
      Multiple pregnancy and preterm labor. Saudi Med J 2004;
      25(5):632-637.

16.   Al-Meshari AA, Gader AM, Al-Jabbari AW, Al-Momen AK, Gad El-
      Rab MO, Babay ZH, Mahmoud N. The prevalence of lupus
      anticoagulant in normal pregnancy and in women with recurrent
      fetal loss – recommendations of laboratory testing for lupus
      anticoagulant. Ann Saudi Med 2004; 24(6):429-433.


ABSTRACTS AND PRESENTATIONS

1.    Gader AM, Al-Mishari AA, Bayoumi NM. Can the free forms of the
      tissue factor pathway inhibitor (TFPI) and protein S be the
      hallmark of the coagulopathy of pre-eclampsia? 4th International
      Symposium of Hematology and Transfusion Medicine, 5-8 October
      2002, Riyadh, Saudi Arabia.




                                 115
116
DEPARTMENT OF OPHTHALM0LOGY




  Chairman:   Samir M. Al-Mansouri, M.D.
              Assistant Professor
              Consultant Ophthalmologist

  Address:    Department of Ophthalmology (#35)
              College of Medicine
              King Saud University
              P.O. Box 2925, Riyadh 11461
              Kingdom of Saudi Arabia
  Phone:      4786100 ext. 1424/1426
  Fax:        4775724




                       117
       DEPARTMENT OF OPHTHALMOLOGY

1.   Abu El-Asrar AM, Al-Bishi SM, Kangave D. Outcome of temporary
     silicone oil tamponade in complex rhegmatogenous retinal
     detachment. Eur J Ophthalmol 2003; 13(5):474-481.

2.   Abu El-Asrar AM, Al-Kharashi SA. Full panretinal photocoagulation
     and early vitrectomy improve prognosis of retinal vasculitis
     associated with tuberculoprotein hypersensitivity (Eales' disease).
     Br J Ophthalmol 2002; 86(11):1248-1251.

3.   Abu El-Asrar AM, Al-Mansouri S, Tabbara KF, Missotten L,
     Geboes K. Immunopathogenesis of conjunctival remodeling in
     vernal keratoconjunctivitis. Eye 2003; in press.

4.   Abu El-Asrar AM, Al-Obeidan SA, Gader AM. Retinal periphlebitis
     resembling frosted branch angiitis with nonperfused central retinal
     vein occlusion. Eur J Ophthalmol 2003;13(9-10):807-812.

5.   Abu El-Asrar AM, Al-Turki R. Primary vitrectomy for repair of
     retinal detachments following cataract surgery.     Saudi J
     Ophthalmol 2004; 18(2):91-96.

6.   Abu El-Asrar AM, Dralands L, Missotten L, Al-Jadaan IA, Geboes
     K. Expression of apoptosis markers in the retinas of humans
     subjects with diabetes. Invest Ophthal & Visual Sci 2004; 45(8):
     2760-2766.

7.   Abu El-Asrar AM, Gader AM, Al-Amro SA, Al-Attas OS.
     Hyperhomocysteinemia and retinal occlusive disease. Eur J
     Ophthalmol 2002; 12(6):495-500.

8.   Abu El-Asrar AM, Geboes K. An immunohistochemical study of
     the „snowbank‟ in a case of pars planitis. Ocul Immunol Inflamm
     2002; 10(2):117-123.

9.   Abu El-Asrar AM, Jesteneiah S, Al-Serhani AM. Regression of
     aneurysmal dilatations in a case of idiopathic retinal vasculitis,
     aneurysms and neuroretinitis (IRVAN) associated with allergic
     fungal sinusitis. Eye 2004; 18(2):197-199.


                                 118
10.   Abu El-Asrar AM, Meersschaert A, Al-Kharashi SA, Missotten L,
      Geboes K.     Immuno-histochemical evaluation of conjunctival
      remodeling in vernal keratoconjunctivitis. Eye 2003; 17(6):767-
      771.

11.   Abu El-Asrar AM, Meersschaert A, Dralands L, Missotten L,
      Geboes K. Inducible nitric oxide synthase and vascular endothelial
      growth factor are colocalized in the retinas of human subjects with
      diabetes. Eye 2004; 18(3):306-313.

12.   Abu El-Asrar AM, Struyf S, Al-Kharashi SA, Missotten L, Van
      Damme J, Geboes K. The T-lymphocyte chemoattractant Mig is
      highly expressed in vernal keratoconjunctivitis. Am J Ophthalmol
      2003; 136(5):853-860.

13.   Abu El-Asrar AM, Struyf S, Van Damme J, Geboes K. Role of
      chemokines in vernal keratoconjunctivitis. Int Ophthalmol Clin
      2003; 43(1):33-39.

14.   Al-Amro SA, Al-Kharfi TM, Thabit AA, Al-Mofada SM. Retinopathy
      of prematurity at a University hospital in Riyadh, Saudi Arabia.
      Saudi Med J 2003; 24(7):720-724.

15.   Al-Jishi Z, Abu El-Asrar AM. Post-traumatic endophthalmitis
      caused by xanthomonas maltophilia. Case report. Saudi J
      Ophthalmol 2003; 17(4):291-294.

16.   Al-Jishi Z, El-Sharawy Y, Abu El-Asrar AM. Multifocal choroiditis
      caused by endemic syphilis (Bejel). Saudi J Ophthalmol 2004;
      18(1):28-30.

17.   Al-Khalaf AK, Abu El-Asrar AM. Retinal venous microaneurysm.
      Case report. Saudi J Ophthalmol 2002; 16(4):309-312.

18.   Al-Otaibi AG. Systemic tuberculosis presenting as decreased
      vision and squint. Case report. Saudi J Ophthalmol 2002;
      16(4):306-308.




                                  119
19.   Al-Rajhi AA, Al-Motowa S, Al-Faran M, Mahmood M, Al-Rajhi AI.
      Amniotic membrane transplantation with and without limbal
      transplantation for ocular surface reconstruction.  Saudi J
      Ophthalmol 2003; 17(4):221-230.

20.   Sennlaub F, Valamanesh F, Vazquez-Tello A, Abu El-Asrar AM,
      Checchin D, Brault S, et al. Cyclooxygenase-2 in human and
      experimental ischemic proliferative retinopathy. Circulation 2003;
      108(2):198-204.

ABSTRACTS AND PRESENTATIONS

1.    Abu El-Asrar AM, Al-Bishi SM, Kangave D. Outcome of temporary
      silicone oil tamponade in complex rhegmatogenous retinal
      detachments. "Saudi Ophthalmology 2004” Combined meeting of
      the 17th Annual Scientific Meeting of the Saudi Ophthalmological
      Society & 21st Annual Symposium of the King Khaled Eye
      Specialist Hospital, King Fahd Cultural Center, Riyadh, 7-10 March
      2004.

2.    Abu El-Asrar AM, Al-Turki R. Primary vitrectomy for repair of
      retinal detachments following cataract surgery. "Saudi
      Ophthalmology 2004” Combined meeting of the 17th Annual
      Scientific Meeting of the Saudi Ophthalmological Society & 21st
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 7-10 March 2004.

3.    Abu El-Asrar AM. Hyperhomocysteinemia and retinal vascular
      occlusion. “Saudi Ophthalmology 2003” - 16th Annual Scientific
      Meeting of Saudi Ophthalmological Society & 20th Annual
      Symposium of the King Khaled Eye Specialist Hospital, King Fahd
      Cultural Center, Riyadh, 2-5 March 2003.

4.    Abu El-Asrar AM. Primary vitrectomy for bullous rhematogenous
      retinal detachments. “Saudi Ophthalmology 2004” Combined
      meeting of the 17th Annual Scientific Meeting of the Saudi
      Ophthalmological Society & 21st Annual Symposium of the King



                                  120
      Khaled Eye Specialist Hospital, King Fahd Cultural Center, Riyadh,
      7-10 March 2004.

5.    Abu El-Asrar AM. Retinal vasculitis. “Saudi Ophthalmology 2003”
      - 16th Annual Scientific Meeting of Saudi Ophthalmological Society
      & 20th Annual Symposium of the King Khaled Eye Specialist
      Hospital, King Fahd Cultural Center, Riyadh, 2-5 March 2003.

6.    Abu El-Asrar AM. Retinopathy as a predictor of other diabetic
      complications.     “Saudi Ophthalmology 2003” - 16th Annual
      Scientific Meeting of Saudi Ophthalmological Society & 20th Annual
      Symposium of the King Khaled Eye Specialist Hospital, King Fahd
      Cultural Center, Riyadh, 2-5 March 2003.

7.    Al-Amro S.       Retinal detachment following LASIK. "Saudi
      Ophthalmology 2004” Combined meeting of the 17th Annual
      Scientific Meeting of the Saudi Ophthalmological Society & 21st
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 7-10 March 2004.

8.    Al-Amro S. Risk factors for acute retinopathy of prematurity.
      "Saudi Ophthalmology 2004” Combined meeting of the 17th Annual
      Scientific Meeting of the Saudi Ophthalmological Society & 21st
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 7-10 March 2004.

9.    Al-Amro SA.     Retinal detachment following LASIK.         “Saudi
      Ophthalmology 2003” - 16th Annual Scientific Meeting of Saudi
      Ophthalmological Society & 20th Annual Symposium of the King
      Khaled Eye Specialist Hospital, King Fahd Cultural Center, Riyadh,
      2-5 March 2003.

10.   Al-Amro SA. Risk factors for acute retinopathy of prematurity.
      “Saudi Ophthalmology 2003” - 16th Annual Scientific Meeting of
      Saudi Ophthalmological Society & 20th Annual Symposium of the
      King Khaled Eye Specialist Hospital, King Fahd Cultural Center,
      Riyadh, 2-5 March 2003.




                                  121
11.   Al-Bishi SM, Abu El-Asrar AM. Outcome of temporary silicone oil
      tamponade in complex rhegmatogenous retinal detachment.
      “Saudi Ophthalmology 2003” - 16th Annual Scientific Meeting of
      Saudi Ophthalmological Society & 20th Annual Symposium of the
      King Khaled Eye Specialist Hospital, King Fahd Cultural Center,
      Riyadh, 2-5 March 2003.

12.   Al-Faleh H, Abu El-Asrar AM. Multiple sclerosis presenting with
      granulomatous iridocyclitis and retinal vasculitis. "Saudi
      Ophthalmology 2004” Combined meeting of the 17th Annual
      Scientific Meeting of the Saudi Ophthalmological Society & 21st
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 7-10 March 2004.

13.   Al-Obeidan S. Full PRP improves the outcome of trabeculectomy
      in neovascular glaucoma. “Saudi Ophthalmology 2003” - 16th
      Annual Scientific Meeting of Saudi Ophthalmological Society & 20th
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 2-5 March 2003.

14.   Al-Sharif AM, Chaudhary IA, Al-Mansouri S. Severe ocular injury
      by unprovoked farm animals. “Saudi Ophthalmology 2003” - 16th
      Annual Scientific Meeting of Saudi Ophthalmological Society & 20th
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 2-5 March 2003.

15.   Fatani RA. Visual rehabilitation in congenital glaucoma. "Saudi
      Ophthalmology 2004” Combined meeting of the 17th Annual
      Scientific Meeting of the Saudi Ophthalmological Society & 21st
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 7-10 March 2004.

16.   Osman E, Al-Obeidan S. Controlled cyclophotocoagulation. "Saudi
      Ophthalmology 2004” Combined meeting of the 17th Annual
      Scientific Meeting of the Saudi Ophthalmological Society & 21st
      Annual Symposium of the King Khaled Eye Specialist Hospital,
      King Fahd Cultural Center, Riyadh, 7-10 March 2004.




                                  122
DEPARTMENT OF ORTHOPEDICS




Chairman:   Dr. Hazem Al-Khawashki, FRCSEd
            Associate Professor of Orthopedics
            Consultant Orthopedic Surgeon

Address:    Department of Orthopedics (#49)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4670870
Fax:        4679436




                      123
            DEPARTMENT OF ORTHOPEDICS

1.    Davidson D, Letts M, Khoshhal K. Pelvic osteomyelitis in children:
      a comparison of decades from 1980-1989 with 1990-2001. J
      Pediatr Orthop 2003; 23(4):514-521.

2.    Khoshhal K, Letts RM. Orthopaedic manifestations of campomelic
      dysplasia. Clin Orthop 2002; 401:65-74.

3.    Khoshhal K, Mukhtar I, Clark P, Jarvis J, Letts M, Splinter W.
      Efficacy of aprotonin in reducing blood loss in spinal fusion for
      idiopathic scoliosis. J Pediatr Orthop 2003; 23(5):661-664.

4.    Khoshhal KI. Sports injuries in children. Saudi J Sports Med 2002;
      6(2):59-66.

5.    Kremli MK, Alshahid AH, Khoshhal KI, Zamzam MM. The pattern
      of developmental dysplasia of the hip. Saudi Med J 2003;
      24(10):1118-1120.

6.    Kremli MK. Septic shock with skin ulceration and infection after
      use of a synthetic hip spica cast for the treatment of congenital
      dislocation of the hip. Case report. Ann Saudi Med 2003; 23(3-
      4):171-172.

7.    Kremli MK. Bioabsorbable rods in Salter's osteotomy. J Pediatr
      Orthop 2002; 11(2):104-109.

8.    Kremli MK. Fixed forefoot adduction after clubfoot surgery. Saudi
      Med J 2003; 24(7):742-744.

9.    Zamzam M. Injuries in skeletally immature knees: pattern of
      lesions and correlation of clinical, MRI, and surgical findings. Saudi
      J Sports Med 2002; 6(1):12-17.

10.   Zamzami M, Khoshhal K. Ankle arthritis.        Saudi J Sports Med
      2002; 6(1):4-11.




                                    124
DEPARTMENT OF PATHOLOGY




Chairman: Saleh S. Al-Hedaithy, Ph.D., ABMM
          Professor of Microbiology (Mycology)
          Consultant Mycologist

Address:   Department of Pathology (#32)
           College of Medicine
           King Saud University
           P.O. Box 2925, Riyadh 11461
           Kingdom of Saudi Arabia
Phone:     4670861
Fax:       4672462




                     125
            DEPARTMENT OF PATHOLOGY

1.   Abdel-Hameed A, Dura WT, Alkhalife IS. An inguinal mass with
     local vascular lesions induced by a lymphatic filarial. Saudi Med J
     2004; 25(8):1106-1108.

2.   Abu-Aisha H, Mitwalli AH, Huraib SO, Al-Wakeel JS, Abid J, Yousif
     KI, Algayyar F, Ramia S. The effect of chemical and heat
     disinfection of the hemodialysis on the spread of hepatitis C virus: a
     prospective study. [Abstract] Saudi Med J 2003; 24 (Suppl
     2):S123.

3.   Al-Hedaithy SS, Fotedar R.       Recovery and studies on
     chlamydospore-negative Candida albicans isolated from clinical
     specimens. Med Mycol 2002; 40(3):301-306.

4.   Al-Hedaithy SS. Spectrum and proteinase production of yeasts
     causing vaginitis in Saudi Arabian women. Med Sci Monit 2002;
     8(7):498-501.

5.   Al-Hedaithy SS. The yeast species causing fungemia at a
     university hospital in Riyadh, Saudi Arabia during a 10-year period.
     Mycoses 2003; 46(8):293-298.

6.   Al-Howiriny T, Al-Sohaibani MO, El-Tahir K, Rafatullah S.
     Prevention of experimentally-induced gastric ulcers in rats by an
     ethanolic extract of "Parsley" Petroselinum crispum. Am J Chin
     Med 2003; 31(5):699-711.

7.   Alkhalife IA. Imported malaria infections diagnosed at the malaria
     referral laboratory in Riyadh, Saudi Arabia. Saudi Med J 2003;
     24(10):1068-1072.

8.   Al-Khattaf AS. No evidence of persistent Helicobacter pylori
     infection in peripheral blood of patients with coronary heart
     disease. Saudi Med J 2004; 25(2):246-247.




                                   126
9.    Al-Majed AA, Abd-Allah AR, Al-Rikabi AC, Al-Shabanah OA,
      Mostafa AM. Effect of oral administration of Arabic gum on
      cisplatin-induced nephrotoxicity in rats. J Biochem Mol Toxicol
      2003; 17(3):146-153.

10.   Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA.
      Protective effects of oral Arabic gum administration on gentamicin-
      induced nephrotoxicity in rats. Pharmacol Res 2002; 46(5):445-
      451.

11.   Al-Meshari AA, Gader AM, Al-Jabbari AW, Al-Momen AK, Gad El-
      Rab MO, Babay ZH, Mahmoud N. The prevalence of lupus
      anticoagulant in normal pregnancy and in women with recurrent
      fetal loss – recommendations of laboratory testing for lupus
      anticoagulant. Ann Saudi Med 2004; 24(6):429-433

12.   Almogren A, Senior BW, Loomes LM, Ikerr MA. Structural and
      functional consequences of cleavage of human secretory and
      human serum immunoglobulin A1 by proteinases from Proteus
      mirabilis and Neisseria meningitides. Infection and Immunity
      2003; 71(6):3349-3356.

13.   Al-Otaibi FE, Kambal AM, Baabad RA. Enterococcal bacteremia
      in a teaching hospital in the Central region of Saudi Arabia. Saudi
      Med J 2004, 25(1):21-25.

14.   Al-Otaibi FE. Isolation of Salmonella paratyphi A from a patient
      with nephrolithiases. Saudi Med J 2003; 24(4):406-408.

15.   Al-Rehaily AJ, Al-Howiriny TA, Al-Sohaibani MO, Rafatullah S.
      Gastroprotective effects of "Amla" Emblica officinalis on in vivo text
      models in rats. Phytomedicine 2002; 9:515-522.

16.   Al-Shedoukhy AA, Al-Garni AA. Hepatocellular carcinoma and
      gallbladder adenocarcinoma – Two primaries with no significant
      risk factors. Saudi J Gastroenterol 2003; 9(3):142-144.




                                    127
17.   Babay H, Kambal AM, Al-Anazy A, Saidu A, Aziz S. Acinetobacter
      blood stream infection in a teaching hospital, Riyadh, Saudi
      Arabia. Kuwait Med J 2003; 35(3):196-201.

18.   Babay HA, Al-Anazy AR, Saidu AB, Kambal AM. Haemophilus
      influenzae type B meningitis in an adult immunocompetent patient.
      Neurosciences 2003; 8(3):188-190.

19.   Babay HA, Al-Anazy AR, Saidu AB, Kambal AM. Haemophilus
      influenzae serotype-B meningitis in an adult immunocompetent
      patient. Saudi Med J 2003; 24(7):783-785.

20.   Babay HA, Kambal AM. Isolation of coryneform bacteria from
      blood cultures of patients at a University Hospital in Saudi Arabia.
      Saudi Med J 2004; 25(8):1073-1079.

21.   Begum NN, Al-Khattaf AA, Kambal AM, Yeboah EA. Prevalence
      of H. influenzae biotypes and their clinical significance in a
      University Hospital. Saudi Med J 2003; 24(12):1308-1312.

22.   El-Hazmi MM. Prevalence of HBV, HCV, HIV-1,2 and HTLV-I,II
      infections among blood donors in a teaching hospital in the Central
      region of Saudi Arabia. Saudi Med J 2004; 25(1):26-35.

23.   Fotedar R, Al-Hedaithy SS. Candida dubliniensis at a university
      hospital in Saudi Arabia. J Clin Microbiol 2003; 41(5):1907-1911.

24.   Fotedar R, Al-Hedaithy SS. Identification of chlamydospore-
      negative Candida albicans using CHROMagar Candida medium.
      Mycoses 2003; 46(3-4):96-103.

25.   Fotedar R, Al-Hedaithy SS. Prevalence of Candida dubliniensis
      among germ tube-positive yeasts recovered from the respiratory
      specimens in HIV-negative patients. Mycoses 2004; 47(3-4):150-
      155.




                                   128
26.   Hasnain SM, Al-Frayh AS, Al-Suwaine A, Gad El-Rab MO, Fatima
      K, Al-Sedairy S. Cladosporium and respiratory allergy: diagnostic
      implications in Saudi Arabia. Mycopathologia 2004; 157(2):171-
      179.

27.   Khan ZA, Alkhalife IS, Fathalla SE. Prevalence of hepatitis C virus
      among bilharziasis patients. Saudi Med J 2004; 25(2):204-206.

28.   Mansour M, Daba MH, Gado A, Al-Rikabi AC, Al-Majed AA.
      Protective effect of L-arginine against nephrotoxicity induced by
      cyclosporine in normal rats. Pharmacol Res 2002; 45(6):441-446.

29.   Saad SY, Najjar TA, Daba MH, Al-Rikabi AC. Inhibition of nitric
      oxide synthase aggravates cisplatin-induced nephrotoxicity: effect
      of 2-amino-4-methylpyridine. Chemotherapy 2002; 48(6):309-315.

30.   Shakoor Z. Antenatal screening for syphilis in a tertiary care
      hospital in Riyadh. Ann Saudi Med 2004; 24(4):262-264.

31.   Shakoor Z. Serial evaluation of percentage of activated T-
      lymphocytes in peripheral blood of human immunodeficiency virus
      infected individuals as a prognostic marker. Saudi Med J 2003;
      24(6):632-636.

32.   Twum-Danso K, Al-Mazrou AM, Kambal AM, Al-Zamil F. Penicillin
      resistance in serogroups/serotypes of Streptococcus pneumoniae
      causing invasive infections in Central Saudi Arabia. Saudi Med J
      2003; 2003; 24(11):1210-1213.


ABSTRACTS AND PRESENTATIONS

1.    Bakir TM. Age-specific prevalence of antibody to hepatitis C virus
      (HCV) among the Saudi population. [Abstract] Saudi Med J 2003;
      24 (Suppl 2): S120.




                                   129
130
  DEPARTMENT OF PEDIATRICS




Chairman:   Dr. Fahad A. Al-Zamil, MD, DCH
            Associate Professor of Pediatrics,
            Consultant Pediatrician

Address:    Department of Pediatrics (#39)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4670807
Fax:        4679463




                       131
             DEPARTMENT OF PEDIATRICS
1.   Abu-Ekteish FM, Zahraa JN. Hypernatremic dehydration and
     acute gastro-enteritis in children. Ann Trop Paediatr 2002;
     22(3):245-249.

2.   Abu-Ekteish FM, Zahraa JN, Al-Mobaireek KF, Nasir AA, Al-Frayh
     AR. The management of acute severe asthma in a pediatric
     intensive care unit. Saudi Med J 2003; 24(4):388-390.

3.   Al-Amro SA, Al-Kharfi TM, Thabit AA, Al-Mofada SM. Retinopathy
     of prematurity at a University hospital in Riyadh, Saudi Arabia.
     Saudi Med J 2003; 24(7):720-724.

4.   Al-Husain M. Body mass index for Saudi children with Down's
     syndrome. Acta Paediatr 2003; 92(12):1482-1485.

5.   Al-Husain M. Growth charts for children with Down's syndrome in
     Saudi Arabia: birth to 5 years. Int J Clin Pract 2003; 57(3):170-
     174.

6.   Al-Jarallah AS, Lardhi AA, Hassan AA. Endocarditis prophylaxis in
     children with congenital heart disease. A parent's awareness.
     Saudi Med J 2004; 25(2):182-185.

7.   Al-Jarie A, Al-Mohsen I, Al-Jumaah S, Al-Hazmi M, Al-Zamil F, Al-
     Zahrani M, Al-Modovar E, Al-Dayel F, Al-Arishi H, Shehrani D,
     Martins J, Al-Mehaideb A, Rossi L, Olaiyan I, Le Quesna G, Al-
     Mazrou A. Pediatric gastrointestinal basidiobolomycosis. Pediatr
     Infect Dis J 2003; 22(11):1007-1014.

8.   Al-Jumah M, Majumdar R, Al-Rajeh S, Chaves-Carbello E, Salih M,
     Al-Shahwan S, Al-Bubiey K, Al-Uthaim S. Molecular analysis of the
     spinal muscular atrophy and neuronal apoptosis inhibitory protein
     genes in Saudi patients with spinal muscular atrophy. Saudi Med J
     2003; 24(10):1052-1054.

9.   Al-Otaibi FE, Kambal AM, Baabad RA. Enterococcal bacteremia
     in a teaching hospital in the Central region of Saudi Arabia. Saudi
     Med J 2004, 25(1):21-25.


                                  132
10.   Al-Qahtani F, Al-Salloum AA. Chanarin-Dorfman Syndrome: a
      case report. Ann Saudi Med 2002; 22:354-355.

11.   Al-Salloum AA. Cyclophosphamide therapy for lupus nephritis:
      poor renal survival in Arab children. Pediatr Nephrol 2003;
      18(4):357-361.

12.   Al-Salloum AA. Experience with vesicoureteral reflux in Saudi
      children: clinical characteristics. Curr Pediatr Rest 2003; 7(1).

13.   Al-Salloum AA. Lupus nephritis in childhood. Saudi J Kidney Dis
      Transplant 2003; 14(1):43-56.

14.   Al-Salloum AA. Non-surgical approach to the management of
      vesicoureteral reflux: determinants of non-compliance in Saudi
      children. Emirates Med J 2003; 21(1):41-44.

15.   Al-Salloum AA. Pulse cyclophosphamide therapy for steroid-
      resistant focal segmental glomerulosclerosis in children. Ann
      Saudi Med 2004; 24(1):27-30.

16.   Al-Salloum AA. Pulse cyclophosphamide therapy in steroid
      resistant nephrotic syndrome associated with mesangial
      proliferative glomerulonephritis. Saudi J Kidney Dis Transplant
      2004; 15(2):129-134.

75.   Alzoum M, Alorainy IA, Al-Hussain M, Al-Ruhaimi K. Multiple
      pericallosal lipomas in two siblings with frontonasal dysplasia. Am
      J Neuroradiol 2002; 23(4):730-731.

17.   El-Mouzan MI, Abdullah AM. Yield of colonoscopy in children with
      rectal bleeding. Saudi Med J 2004; 25(8):998-1001.

18.   El-Mouzan MI, Al-Mofleh IA, Abdullah AM, Al-Rashed AR.
      Indications and yield of upper gastrointestinal endoscopy in
      children. Saudi Med J 2004; 25(9):1223-1225.

19.   El-Mouzan MI. Health Home Care of Children. (Health education
      book in Arabic) Al-Obeikan Publishing House, 2002.


                                   133
20.   Essa M, El-Medany Y, Hajjar W, Hariri Z, Al-Mulhim F, Salih M,
      Ashour M, Al-Kattan K. Maximal thymectomy in children with
      myasthenia gravis. Eur J Cardiothorac Surg 2003; 24(2):187-189.

21.   Hasnain SM, Al-Frayh AS, Al-Suwaine A, Gad El-Rab MO, Fatima
      K, Al-Sedairy S. Cladosporium and respiratory allergy: diagnostic
      implications in Saudi Arabia. Mycopathologia 2004; 157(2):171-
      179.

22.   Odetola FO, Bhatt-Mehta V, Zahraa J, Moler FW, Custer JR.
      Cisatracurium infusion for neuromuscular blockade in the pediatric
      intensive care unit: A dose-finding study. Pediatr Crit Care Med
      2002; 3(3):250-254.

23.   Twum-Danso K, Al-Mazrou AM, Kambal AM, Al-Zamil F. Penicillin
      resistance in serogroups/serotypes of Streptococcus pneumoniae
      causing invasive infections in Central Saudi Arabia. Saudi Med J
      2003; 2003; 24(11):1210-1213.

24.   Zahraa JN, Abu-Ekteish F, Al-Bassam AR, Nasir AA. Perforated
      Meckel's diverticulum in a neonate mimicking necrotizing
      enterocolitis. Pediatr Emerg Care 2003; 19(6):418-419.

25.   Zahraa JN, Nasser AA, Al-Nemri A, Aqeel AY, Al-Jarallah AS.
      Congenital central hypoventilation syndrome: Diagnosis and the
      challenge of management. Emirates Med J 2002; 20(3):389-391.

ABSTRACTS AND PRESENTATIONS

1.    Abdullah AM. Galactosemia. The 2nd International Symposium on
      Pediatric Gastroenterology, Hepatology and Nutrition, King Faisal
      Specialist Hospital & Research Center, Riyadh, 13-15 January
      2003.

2.    Jarallah AA. Dietary intervention in the treatment of autism. The
      2nd International Symposium on Pediatric Gastroenterology,
      Hepatology and Nutrition, King Faisal Specialist Hospital &
      Research Center, Riyadh, 13-15 January 2003.



                                  134
DEPARTMENT OF PHARMACOLOGY




Chairman: Abdulrahman A. Al-Motrefi, Ph.D.
          Professor of Medical Pharmacology

Address:   Department of Pharmacology (#31)
           College of Medicine
           King Saud University
           P.O. Box 2925, Riyadh 11461
           Kingdom of Saudi Arabia
Phone:     4670840
Fax:       4679289




                       135
         DEPARTMENT OF PHARMACOLOGY

1.   Al-Arfaj AS, Alballa SR, Mustafa AA, Al-Tuwaijri AS, Al-Humayyd
     MS, Al-Dalaan AN. Effect of diclofenac alone or in combination
     with     alpha-tocopherol  on     the    oxidative   activity of
     polymorphonuclear leukocytes in healthy and osteoarthritic
     individuals. Saudi Med J 2004; 25(2):198-203.

2.   Al-Arfaj AS, Mustafa AA, Alballa SR, Al-Tuwaijri AS, Al-Dalaan AN.
     Interaction of allopurinol and non-steroidal anti-inflammatory drugs
     on the carrageen-induced rat paw edema. Saudi Med J 2003;
     24(9):936-940.

3.   Ali AT, Al-Swayeh OA. Honey potentiates the gastric protection
     effects of sucralfate against ammonia-induced gastric lesions in
     rats. Saudi J Gastroenterol 2003; 9(3):117-123.

4.   Al-Motrefi AA, Dzimiri N, Premkumar LS. Investigation of the
     antifibrillatory drug interactions between propranolol and bretylium
     in perfused rabbit hearts. Br J Pharmacol 2003; 138:143.

5.   Ashour M, Hajjar W, Al-Kattan K, Essa M, Al-Motrefi AA, Al-
     Saddique A, El-Bakry A. Intra-operative heparin release during
     lung surgery. Eur J Cardiothorac Surg 2004; 25(5):839-843.

6.   El-Medany AH, Hagar HH, Zakaria FA. Comparative study for the
     cardioprotective effects of nicorandil and KRN4884 (ATP-sensitive
     potassium channel openers) in ischemic reperfused isolated
     rabbit's heart. Saudi Pharmac J 2003; 11(3):77-86.

7.   El-Medany AH, Hagar HH. Effect of fluconazole on the fertility of
     male rabbits. Arneimittelforschung 2002; 52(8):636-640.

8.   Hagar HH. Folic acid and vitamin B12 supplementation attenuates
     isoprenaline-induced myocardial infarction in experimental
     hyperhomocysteinemic rats. Pharmacol Res 2002; 46(3):213-219.




                                  136
9.    Haggar HH. The protective effect of taurine against cyclosporine
      A-induced oxidative stress and hepatotoxicity in rats. Toxicol Lett
      2004; 151(2):335-343.

10.   Mahgoub AA, El-Medany AA, Hagar HH, Mustafa AA, El-Sabah
      DM. Evaluating the prophylactic potential of zafirlukast against the
      toxic effects of acetic acid on the rat colon. Toxicol Lett 2003;
      145(1):79-87.

11.   Mahgoub AA, El-Medany AH, Hagar HH, Sabah DM. Protective
      effect of natural honey against acetic-induced colitis in rats. Trop
      Gastroenterol 2002; 23(2):82-87.

12.   Mahgoub AA. Grapefruit juice potentiates the anti-inflammatory
      effects of diclofenac on the carrageenan-induced rat's paw
      oedema. Pharmacol Res 2002; 45(1):1-4.

13.   Mahgoub AA. Thymoquinone protects against experimental colitis
      in rats. Toxicol Lett 2003; 143(2):133-143.

14.   Mahgoub AA, El-Medany AH, Sabah DM, Ali AT. Potential
      protective effects of sucralfate against acetic acid-induced colitis in
      rats. J Digestive Med 2003; 4(1).

15.   Mobarok-Ali AT, Al-Swayeh OA. Honey potentiates the gastric
      protection effects of sucralfate against ammonia-induced gastric
      lesions in rats. Saudi J Gastroenterol 2003; 9(3):117-123.

16.   Mobarok-Ali AT. Prevention of ammonia-induced gastric lesions in
      rats by natural honey. J Nutr Environ Med 2003; 13(4):239-246.




                                    137
138
DEPARTMENT OF PHYSIOLOGY




Chairman:   Ali S. Al-Tuwaijri, Ph.D.
            Professor of Physiology

Address:    Department of Physiology (#29)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4670848
Fax:        4671046




                      139
            DEPARTMENT OF PHYSIOLOGY

1.   Abdel-Halim RE, Al-Tuwaijri AS, El-Faqih SR, Mitwalli AH.
     Extraction of urinary bladder stone as described by Abul-Qasim
     Khalaf Ibn Abbas Alzahrawi (Albucasis) (325-404 H, 930-1013
     AD). A translation of original text and a commentary. Saudi Med
     J 2003; 24(12):1283-1291.

2.   Abu El-Asrar AM, Al-Obeidan SA, Gader AM. Retinal periphlebitis
     resembling frosted branch angiitis with nonperfused central retinal
     vein occlusion. Eur J Ophthalmol 2003;13(9-10):807-812.

3.   Abu El-Asrar AM, Gader AM, Al-Amro SA, Al-Attas OS.
     Hyperhomocysteinemia and retinal occlusive disease. Eur J
     Ophthalmol 2002; 12(6):495-500.

4.   Al-Arfaj AS, Alballa SR, Mustafa AA, Al-Tuwaijri AS, Al-Humayyd
     MS, Al-Dalaan AN. Effect of diclofenac alone or in combination
     with     alpha-tocopherol  on     the   oxidative    activity of
     polymorphonuclear leukocytes in healthy and osteoarthritic
     individuals. Saudi Med J 2004; 25(2):198-203.

5.   Al-Arfaj AS, Mustafa AA, Alballa SR, Al-Tuwaijri AS, Al-Dalaan AN.
     Interaction of allopurinol and non-steroidal anti-inflammatory drugs
     on the carrageen-induced rat paw edema. Saudi Med J 2003;
     24(9):936-940.

6.   Al-Ayadhi LY.      Sex hormones, personality characters and
     professional status among Saudi females. Saudi Med J 2004;
     25(6):711-716.

7.   Al-Ayadhi LY. The influence of academic stress on free radicals
     production in the blood of students during examinations. Ann
     Saudi Med 2003; 23(1-2):51-54.

8.   Al-Ghumlas AK, Gader AM, Al-Faleh FZ.              Haemostatic
     abnormalities in liver disease. Should haemostatic tests be
     included among liver function test? Gastroenterol Hepatol 2003;
     in press.


                                  140
9.    Al-Ghumlas AK, Gader AM. The liver and the haemostatic
      system. Saudi J Gastroenterol 2003; 9(2):59-68.

10.   Al-Khlaiwi T, Meo SA. Association of mobile phone radiation with
      fatigue, headache, dizziness, tension and sleep disturbance in
      Saudi population. Saudi Med J 2004; 25(6):732-736.

11.   Al-Meshari AA, Gader AM, Al-Jabbari AW, Al-Momen AK, Gad El-
      Rab MO, Babay ZH, Mahmoud N. The prevalence of lupus
      anticoagulant in normal pregnancy and in women with recurrent
      fetal loss – recommendations of laboratory testing for lupus
      anticoagulant. Ann Saudi Med 2004; 24(6):429-433.

12.   Al-Tuwaijri AS, Gader AM, Husain A, El-Mubarak M, Meo SA,
      Shaikh ZA, Omar SA. Zain Manual of Experimental Physiology,
      vol I, Fair Fan Publishers, Karachi, Pakistan, 2003.

13.   Al-Tuwaijri AS, Gader AM, Husain A, El-Mubarak M, Meo SA,
      Shaikh ZA, Omar SA. Zain Manual of Experimental Physiology,
      vol II, Fair Fan Publishers, Karachi, Pakistan, 2003.

14.   Al-Tuwaijri AS. Handbook of Renal Physiology, 1st edition, Fair
      Fan Publishers, Karachi, Pakistan, 2003.

15.   Alzoghaibi MA, Walsh SW, Willey A, Fowler AA III, Graham MF.
      Linoleic acid, but not oleic acid, upregulates the production of
      interleukin-8 by human intestinal smooth muscle cells isolated
      from patients with Crohn's disease. Clin Nutr 2003; 22(6):529-535.

16.   Alzoghaibi MA, Walsh SW, Willey A, Yager DR, Fowler AA III,
      Graham MF. Linoleic acid induces interleukin-8 production by
      Crohn's human intestinal smooth muscle cells via arachidonic acid
      metabolites. Am J Physiol Gastrointest Liver Physiol 2004;
      286(4):G528-537.

17.   Arian SA, Shah MH, Meo SA, Jamal Q. Estrogen receptors in
      human thyroid gland. An immunohistohemical study. Saudi Med J
      2003; 24(2):174-178.



                                  141
18.   Bokhari SS, Ahmad HR, Subhan MM, Ali SA, Khan MN. Cardiac
      acceleration as a marker of vagal withdrawal in heart rate control
      during exercise in humans.      J Pakistan Med Assoc 2003;
      53(8):375-378.

19.   Gader AM, Al-Momen AK, Osman A, Al-Hori I. Blood donor
      potential in Saudi Arabia. The war and peace experience.
      Transfusion Today 2003; 54:4-6.

20.   Habib SS, Aslam M. High risk levels of lipoprotein(a) in Pakistani
      patients with type 2 diabetes mellitus. Saudi Med J 2003;
      24(6):647-651.

21.   Habib SS, Aslam M. Risk factors, knowledge and health status in
      diabetic patients. Saudi Med J 2003; 24(11):1219-1224.

22.   Haidara MA, Ibrahim IM, Al-Tuwaijri AS, Awadalla SA, Yaseen H.
      Effect of -tocopherol on glucose uptake and contractility in rat
      skeletal muscle. Med Sci Monit 2003 9(5):BR174-177.

23.   Meo SA, Al-Khlaiwi T. Health hazards of welding fumes. Saudi
      Med J 2003; 24(11):1176-1182.

24.   Meo SA, Azeem MA, Subhan MM. Lung function in Pakistani
      welding workers. J Occup Environ Med (USA) 2003; 45(10):1068-
      1073.

25.   Meo SA. Book on Multiple-Choice Questions in Physiology. Fan
      Fair Publishers, Karachi, Pakistan, 2003.

26.   Meo SA. Chest radiological findings in cement mill workers.
      Saudi Med J 2003; 24(3):447-450.

27.   Meo SA. Chest radiological findings in Pakistani cement mill
      workers. Saudi Med J 2003; 24(3):287-290.

28.   Meo SA. Congenital absence of gall bladder in a young Saudi
      medical student. Clinical, laboratory findings and analysis of body
      composition. Saudi Med J 2004; 25(10):1495-1496.


                                   142
29.   Meo SA. Health hazards of cement dust. Saudi Med J 2004;
      25(9):1153-1159.

30.   Meo SA. Hematologic findings in male X-ray technicians. Saudi
      Med J 2004; 25(7):852-856.

31.   Meo SA. Meo's Human Physiology Systemic and Applied [Book].
      Fan Fair Publishers, Karachi, Pakistan, 2003.

32.   Meo SA. Occupational hazards of cement dust on oral cavity.
      Pakistan J Orthodontics Pediatr Community Dentistry 2002; 12:34-
      37.

33.   Meo SA.     Spirometric evaluation of lung function (maximal
      voluntary ventilation) in welding workers. Saudi Med J 2003;
      24(6):660-664.

34.   Subhan MM, Butler TJ, Reed JW. Effect of repetitive exercise
      testing on breathlessness in humans. Clin Sci 2003; 105(2):243-
      250.

ABSTRACTS AND PRESENTATIONS

1.    Ballow AA, Huraib S, Gader AM, Mitwalli A, Al-Wakeel J.
      Haemostatic activation markers in patients with chronic renal
      failure.   4th International Symposium of Hematology and
      Transfusion Medicine, 5-8 October 2002, Riyadh, Saudi Arabia.

2.    Gader AM, Al-Mishari AA, Bayoumi NM. Can the free forms of the
      tissue factor pathway inhibitor (TFPI) and protein S be the
      hallmark of the coagulopathy of pre-eclampsia? 4th International
      Symposium of Hematology and Transfusion Medicine, 5-8 October
      2002, Riyadh, Saudi Arabia.

3.    Gader AM, Bayoumy NM, Al-Momen AK. A 14 years audit on the
      use of blood components at King Khalid University Hospital
      (KKUH), Riyadh. 27th Congress of the International Society of




                                 143
     Blood Transfusion (ISBT), 24-28 August 2002, Vancouver, BC.
     Abstract published in Vox Sanguinis 2002; 83(suppl 2):200.

4.   Meo SA. Lung function and surface electromyography (SEM) of
     intercostals muscles in cement mill workers. Proceedings of the
     First Regional Occupational and Environmental Medicine
     Conference, Dammam, 14-16 October 2002; Abstract p. 9.

5.   Subhan MM, Ahmad HR, Kazmi KA, Ahmed N, Ali SA, Bokhari
     SS, Mariam T. Exercise induced dyspnoea in patients with chest
     pain. 8th Pakistan Physiological Society Meeting, March 2002.

6.   Subhan MM, Ali SA, Bokhari SS, Khan MN, Sabir S, Ahmad HR.
     The relationship between body mass index and breathlessness
     during exercise in man. 5th Scientific Congress Federation of
     Asian and Oceanic Physiological Societies (FAOPS) Meeting,
     Kuala Lumpur, September 2002.




                                144
DEPARTMENT OF RADIOLOGY &
     MEDICAL IMAGING




Chairman: Saleh Ali Al-Smayer, MD
          Assistant Professor of Radiology

Address:   Department of Radiology and
           Medical Imaging (#40)
           College of Medicine
           King Saud University
           P.O. Box 2925, Riyadh 11461
           Kingdom of Saudi Arabia
Phone:     4671155
Fax:       4671746




                     145
           DEPARTMENT OF RADIOLOGY &
                MEDICAL IMAGING

1.   Abou El-Ella KM, Mohamed ON, Al-Sebayel MI, Al-Smayer SA, Al-
     Mofleh IA. Management of post-laparoscopic cholecystectomy
     major bile duct injury: comparison of MRCP with conventional
     methods. Saudi J Gastroenterol 2004; 10(1): 8-15.

2.   Adetiloye VA, Al-Damegh S. Sonographic evaluation of plaque
     morphology     in  haemodynamic      and   non-haemodynamic
     symptomatic carotid artery stenoses. Afr J Med Med Sci 2003;
     32(4):381-385.

3.   Al-Boukai AA, Al-Arfaj AS. Rheumatoid arthritis. Radiological
     changes in the cervical spine. Saudi Med J 2003; 24(4):396-399.

4.   Al-Damegh SA. Ultrasound guided fine needle aspirations using
     25G needle as a new technique for a wide range of pathological
     conditions. Saudi Med J 2004; 25(10):1374-1377.

5.   Al-Maatouq MA, El-Desouki MI, Othman SA, Mattar EH, Babay ZA,
     Addar M. Prevalence of osteoporosis among postmenopausal
     females with diabetes mellitus. Saudi Med J 2004; 25(10):1423-
     1427.

6.   Al-Mazrou KA, Alorainy IA, Al-Dousary SH, Richardson MA. Facial
     nerve anomalies in association with congenital hearing loss. Int J
     Pediatr Otorhinolaryngol 2003; 67(12):1347-1353.

7.   Alzoum M, Alorainy IA, Al-Hussain M, Al-Ruhaimi K. Multiple
     pericallosal lipomas in two siblings with frontonasal dysplasia. Am
     J Neuroradiol 2002; 23(4):730-731.

8.   El-Desouki MI. Osteoporosis in postmenopausal Saudi women
     using dual x-ray bone densitometry.    Saudi Med J 2003;
     24(9):953-956.




                                  146
9.    El-Desouki MI. Osteoporosis in postmenopausal Saudi women
      using dual x-ray bone densitometry.    Saudi Med J 2003;
      24(9):953-956.

10.   El-Desouki MI, Othman SM, Fouda MA. Bone mineral density and
      bone scintigraphy in adult Saudi female patients with
      osteomalacia. Saudi Med J 2004; 25(3):355-358.

11.   El-Kayali AA, Al-Bakry A, Iqbal K, Al-Salman M, Rabee H, Al-
      Smayer S, Murtuza M, Noor M, Al-Saadi M. Accuracy of duplex
      scan in the management of chronic leg ischaemia. Emirates Med
      J 2004; 22(1):53-56.

12.   El-Sharkawy MS. Non-contrast helical computed tomography in
      ureteral calculi. Medical Journal of Cairo University 2002;
      70(2):241-247.

13.   El-Tinay OY, Khan IA, Noureldin OH, Al-Boukai AA. Caecal
      lipoma causing colo-colonic intussusception.     Saudi J
      Gastroenterol 2003; 9(3):145-147.

14.   Gaurano JL, Joharjy IA. Middle ear cholesteatoma: characteristic
      CT findings in 64 patients. Ann Saudi Med 2004; 24(6):442-447.

15.   Othman S, El-Desouki MI. Bone scan appearance in aggressive
      osteogenic sarcoma with pleural, lung, bone and soft-tissue
      metastases. Clin Nucl Med 2003; 28(11):926.

16.   Othman SM, El-Desouki MI. Neonatal gynecomastia visualized
      during Tc-99m pertechnetate thyroid scintigraphy. Clin Nucl Med
      2003; 28(12):988-989.




                                 147
148
  DEPARTMENT OF SURGERY




Chairman:   Riyadh A. Talic, FRCSEd.
            Professor of Surgery
            Consultant Urologist

Address:    Department of Surgery (#37)
            College of Medicine
            King Saud University
            P.O. Box 2925, Riyadh 11461
            Kingdom of Saudi Arabia
Phone:      4671575
Fax:        4679493




                      149
              DEPARTMENT OF SURGERY

1.   Abdel Aziz A, Bakir MB, Al-Satli RA, Samarkandi AH, Fouda M.
     Intraoperative evaluation of graft patency in off-pump coronary
     artery bypass grafting. J Saudi Heart Assoc 2003; 15(1):8-12.

2.   Abdel-Halim RE. Clinical research methodology. A course report.
     Saudi Med J 2004; 25(1):110-111.

3.   Abdel-Halim RE, Abdel-Maguid TE. The functional anatomy of the
     uretero-vesical junction. A historical review. Saudi Med J 2003;
     24(8):815-819.

4.   Abdel-Halim RE, Al-Tuwaijri AS, El-Faqih SR, Mitwalli AH.
     Extraction of urinary bladder stone as described by Abul-Qasim
     Khalaf Ibn Abbas Alzahrawi (Albucasis) (325-404 H, 930-1013
     AD). A translation of original text and a commentary. Saudi Med J
     2003; 24(12):1283-1291.

5.   Abdulwahab AA, Hassan S, Al-Nuaim LA, Abdel Halim R. Pelvic
     hematoma resulting in obstructive uropathy. Saudi Med J 2003;
     24(11):1254-1255.

6.   Abou El-Ella KM, Mohamed ON, Al-Sebayel MI, Al-Smayer SA, Al-
     Mofleh IA. Management of post-laparoscopic cholecystectomy
     major bile duct injury: comparison of MRCP with conventional
     methods. Saudi J Gastroenterol 2004; 10(1): 8-15.

7.   Al-Abdulkareem A, El-Bakry AA.        Bowel anastomosis.    A
     comparative study of various surgical techniques. Saudi Med J
     2004; 25(1):123.

8.   Al-Akeely MH. Dual thyroid ectopia.        Saudi Med J 2003;
     24(9):1021-1023.

9.   Al-Akeely MH. Management of complicated gallstone disease
     during pregnancy. Saudi J Gastroenterol 2003; 9(3):135-138.



                                 150
10.   Al-Akeely MH, Alam MK, Al-Salamah SM, Abdu MA, Al-Temi IN,
      Mohammed AA. Initial factors predicting rebleeding and death in
      bleeding peptic ulcer disease. Saudi Med J 2004; 25(5):642-647.

11.   Al-Bassam A, Gado A.        Feminizing genital reconstruction:
      experience with 52 cases of ambiguous genitalia. Eur J Pediatr
      Surg 2004; 14(3):172-178.

12.   Al-Bassam A. Late presentation of tracheobronchial foreign body
      aspiration in children. J Trop Pediatr 2004; accepted.

13.   Al-Bassam A. Surgical management of severe peptic esophageal
      stricture in children. Hepatogastroenterology 2003; 50(51):714-
      717.

14.   Al-Bassam A.       Two-post versus three-post laparoscopic
      appendectomy in children with uncomplicated appendicitis.
      Pediatric Endosurgery and Innovative Techniques 2002; 6(4):255-
      260.

15.   Al-Qattan MM. A penetrating intraosseous ganglion of the
      triquetrum causing ulnar nerve compression. Hand Surg 2004;
      9(1):101-103.

16.   Al-Qattan MM.    Acquired localized subcutaneous cavernous
      vascular malformations of the hand. J Hand Surg [Br] 2004;
      29(2):139-143.

17.   Al-Qattan MM. Assessment of the motor power in older children
      with obstetric brachial plexus palsy. J Hand Surg [Br] 2003;
      28(1):46-49.

18.   Al-Qattan MM. Classification of secondary shoulder deformities in
      obstetric brachial plexus palsy. J Hand Surg [Br] 2003; 28(5):483-
      486.

19.   Al-Qattan MM. Congenital duplication of the palm in a patient with
      multiple anomalies. J Hand Surg {Br] 2003; 28(3):276-279.



                                  151
20.   Al-Qattan MM. Identification of the phrenic nerve in surgical
      exploration of the brachial plexus in obstetrical palsy. J Hand Surg
      [Am] 2004; 29(3):391-392.

21.   Al-Qattan MM. Latissimus dorsi transfer for external rotation
      weakness of the shoulder in obstetric brachial plexus palsy. J
      Hand Surg [Br] 2003; 28(5):487-490.

22.   Al-Qattan MM. Obstetric brachial plexus associated with breech
      delivery. Ann Plast Surg 2003; 51(3):257-264.

23.   Al-Qattan MM. Obstetric brachial plexus palsy. An experience
      from Saudi Arabia. Semin Plast Surg 2004; 18:265-274.

24.   Al-Qattan MM. On the emerging evidence of a new category of
      duplication in the human's hand: the dorsoventral duplication.
      Plast Reconstr Surg 2004; 114(5):1233-1237.

25.   Al-Qattan MM. Refinements in the technique of 'awake' electrical
      nerve stimulation in the management of chronic low ulnar nerve
      injuries. Injury 2004; 35(11):1110-1115.

26.   Al-Qattan MM. Technical modifications and extended applications
      of the distally based adipofascial flap for dorsal digital defects.
      Ann Plast Surg 2004; 52(2):168-173.

27.   Al-Qattan MM. Tendon transfer to reconstruct wrist extension in
      children with obstetric brachial plexus palsy. J Hand Surg [Br]
      2003; 28(2):143-157.

28.   Al-Qattan MM. The reversed dermis flap in a homodigital or cross
      finger manner for soft reconstruction in dorsal finger defects: reply.
      Ann Plast Surg 2004; 53(3):299.

29.   Al-Qattan MM. Type 6 avulsion of the insertion of the flexor
      digitorum profundus tendon. Injury 2004; in press.

30.   Al-Qattan MM. Ulnar nerve compression at the wrist by the
      accessory abductor digiti minimi muscle: wrist trauma as a
      precipitating factor. Hand Surg 2004; 9(1):79-82.


                                    152
31.   Al-Qattan MM, Al-Kattan WM. Skin wound healing, ischemia-
      reperfusion injury and nerve regeneration. Similarities in the
      sequential events and molecular basis. Can J Plast Surg 2004;
      12:131-133.

32.   Al-Qattan MM, El-Shayeb A, Rasool MN. An intramuscular
      myxoma of the hand. Hand Surg 2004; 9(1):97-9.

33.   Al-Qattan MM, Hashem F, Helmi A. Irreducible tuft fractures of the
      distal phalanx. J Hand Surg [Br] 2003; 28(1):18-20.

34.   Al-Qattan MM, Hashem F. Yet another use for the VAC machine.
      Ann Plast Surg 2004; 53(3):299.

35.   Al-Qattan MM, Hashem FK, Rasool MN, El-Shayeb A, Hassanain
      J. A unique fracture pattern of the proximal phalanx in children:
      fractures through the phalangeal neck with an attached dorsal
      bony flange. Injury 2004; 35(11):1185-1191.

36.   Al-Qattan MM, Hashem FK. An alternative approach for correction
      of Stahl's ear. Ann Plast Surg 2004; 52(1):105-108.

37.   Al-Qattan MM, Rasool MN, El-Shayeb A. Remodeling in a
      malunited phalangeal neck fracture. Injury 2004; 35(11):1207-
      1210.

38.   Al-Saddique AA, Elsaegh MM, Fouda MA.             Aortic valve
      replacement in a patient with an aberrant left coronary artery.
      Asian Cardiovasc Thorac Ann 2003; 11(2):169-170.

39.   Al-Saddique AA. Graduate education in surgery in the Kingdom of
      Saudi Arabia. The challenge of growing pains. Saudi Med J 2004;
      25(4):424-428.

40.   Al-Saddique AA. Medical liability.    The dilemma of litigations.
      Saudi Med J 2004; 25(7):901-906.




                                  153
41.   Al-Salamah SM. Prevalence of hepatitis in bleeding oesophageal
      varices – experience of Gastrointestinal Bleeding Unit (GIBU),
      Riyadh Medical Complex. Emirates Med J 2002; 20(2):157-164.

42.   Al-Sebayel M, Khalaf H. Starting the liver transplant program at
      King Faisal Specialist Hospital and Research Center in Saudi
      Arabia: early experience and future expectations. Transplant Proc
      2003; 35(7):2781-2782.

43.   Al-Sebayel MI. High bile duct injury following laparoscopic
      cholecystectomy. Saudi Med J 2003; 24(9):971-973.

44.   Al-Sebayel MI. The efficiency in the utilization of potential donors
      for organ transplantation in Riyadh, Saudi Arabia. Saudi Med J
      2003; 24(7):758-760.

45.   Al-Sebayel MI, Al-Enazi AM, Al-Sofayan MS, Al-Saghier MI, Khalaf
      HA, Kabbani MA, Nafae OM, Khuroo SS. Improving organ
      donation in Central Saudi Arabia. Saudi Med J 2004; 25(10):1366-
      1368.

46.   Ashour M, Hajjar W, Al-Kattan K, Essa M, Al-Motrefi AA, Al-
      Saddique A, El-Bakry A. Intra-operative heparin release during
      lung surgery. Eur J Cardiothorac Surg 2004; 25(5):839-843.

47.   Bakir MB.        Intraoperative radio frequency ablation of atrial
      fibrillation in patients with mitral valve disease. Alexandria Med J
      2002; 44(4):813-832.

48.   Bakir MB, Abdel Aziz A, Al-Satli RA, Samah A, Al-Saddique A,
      Fouda M. Hemodynamic changes in off pump coronary artery
      bypass (OPCAB). J Egypt Soc Cardiothorac Surg 2002; vol. X(2):
      191-200.

49.   Bakir MB, Eid EE.            On-pump beating heart myocardial
      revascularization in "high risk patients." J Egypt Soc Cardiothorac
      Surg 2003, vol. X1(1):61-76.




                                   154
50.   Bismar HA, Alam MK, Al-Akeely MH, Al-Salamah SM, Mohammed
      AA. Outcome of nonoperative management of blunt liver trauma.
      Saudi Med J 2004; 25(3):294-298.

51.   Bismar HA, Al-Salamah SM.            Outcome of laparoscopic
      cholecystectomy in acute biliary pancreatitis. Saudi Med J 2003;
      24(6):660-664.

52.   Bismar HA, El-Bakry AA. Primary hyperparathyroidism.      Saudi
      Med J 2003; 24(11):1214-1218.

53.   Bismar HA, Murshid KR.         Extra adrenal retroperitoneal
      paraganglioma. Saudi Med J 2003; 24(7):778-780.

54.   El-Dawlatly AA, Al-Dohayan A, Abdel-Maguid ME, El-Bakry A,
      Manaa EM. The effects of pneumoperitoneum on respiratory
      mechanics during general anesthesia for bariatric surgery. Obes
      Surg 2004; 14(2):212-215.

55.   El-Dawlatly AA, Al-Dohayan A, Abdel-Maguid ME, Turkistani A,
      Alotaiby WM, Abdelaziz EM.           Variations in dynamic lung
      compliance during endoscopic thoracic sympathectomy with CO2
      insufflation. Clin Auton Res 2003; 13(1):194-197.

56.   El-Dawlatly AA, Al-Dohayan A, Riyad W, Thalaj A, Delvi B, Al-Saud
      S. Thoracoscopic sympathectomy: endobronchial anesthesia vs
      endotracheal anesthesia with intrathoracic CO2 insufflation. J
      Anesth 2002; 16(1):13-16.

57.   El-Dawlatly AA, Al-Kattan K, Hajjar W, Medany Y, El-Bakry A.
      Anesthetic   considerations    on    bronchocarinal    resection
      anastomosis. The Internet Journal of Anesthesiology 2003; vol. 6,
      no. 2.

58.   El-Kayali AA. Ultrasound guided compression repair of post-
      catheterization femoral pseudo-aneurysm. Kuwait Med J 2003;
      35(3):192-195.




                                 155
59.   El-Kayali AA. Polytetrafluoroethylene use for above-knee
      femoropopliteal bypass in critical limb ischemia. Saudi Med J
      2003; 24(6):669-671.

60.   El-Kayali AA, Al-Bakry A, Iqbal K, Al-Salman M, Rabee H, Al-
      Smayer S, Murtuza M, Noor M, Al-Saadi M. Accuracy of duplex
      scan in the management of chronic leg ischaemia. Emirates Med
      J 2004; 22(1):53-56.

61.   El-Medany Y, Hajjar W, Essa M, Al-Kattan K, Hariri Z, Ashour M.
      Predictors of outcome for myasthenia gravis after thymectomy.
      Asian Cardiovasc Thorac Ann 2003; 11(4):323-327.

62.   El-Tinay OE, El-Bakry AA.    Treatment of chronic fistula-in-ano
      using commercial fibrin      glue.    Saudi Med J 2003;
      24(10):1116.1117.

63.   El-Tinay OE, Guraya SY, Noureldin OH. Enterolithiasis. Saudi J
      Gastroenterol 2004; 10(2):96-102.

64.   El-Tinay OY, Khan IA, Noureldin OH, Al-Boukai AA. Caecal
      lipoma causing colo-colonic intussusception.     Saudi J
      Gastroenterol 2003; 9(3):145-147.

65.   El-Watidy S. Prediction of outcome of subarachnoid hemorrhage.
      A proposed scoring system. Neurosciences 2003; 8(4):225-228.

66.   Essa M, El-Medany Y, Hajjar W, Hariri Z, Al-Mulhim F, Salih M,
      Ashour M, Al-Kattan K. Maximal thymectomy in children with
      myasthenia gravis. Eur J Cardiothorac Surg 2003; 24(2):187-189.

67.   Fouda-Neel KA, Soliman SM, Al-Qarni A. Non-intubated vs
      intubated pyeloplasty in children – the KKUH experience. Saudi
      Med J 2003; 24(5 Suppl):S48.

68.   Fouda-Neel KA.         Endoscopic    correction of complicated
      vesicoureteric reflux in children.    Saudi Med J 2003; 24(5
      Suppl):S53.

69.   Fouda-Neel KA. Spontaneous bladder rupture in a non-augmented
      neuropathic bladder. Saudi Med J 2004; 25(2):220-221.


                                  156
70.   Guraya SY, Murshid KR. Malignant duodenocolic fistula. Various
      therapeutic surgical modalities. Saudi Med J 2004; 25(8):1111-
      1114.

71.   Hajjar W, El-Medany Y, Ashour M, Al-Kattan K. Life threatening
      complications caused by bronchogenic and oesophageal
      duplication cysts in a child. J Cardiovasc Surg (Torino) 2003;
      44(1):135-137.

72.   Hajjar W, El-Medany Y, Essa M, Al-Mulhim F, Ashour M, Al-Kattan
      K. Esophago-broncho-cutaneous fistulae and tuberculous
      mediastinal lymphadenitis. J Cardiovasc Surg (Torino) 2003;
      44(1):151-153.

73.   Hajjar W, El-Medany Y, Essa M, Rafay MA, Ashour M, Al-Kattan
      K. Unusual presentation of rib exostosis. Ann Thorac Surg 2003;
      75(2):575.577.

74.   Jalal A. Coronary bypass surgery in Asians: A battle against a
      racist enemy! [Editorial] J Saudi Heart Assoc 2004; 16(2):101-
      105.

75.   Khairy GA, Guraya SY, Murshid KR. Cholesterolosis. Incidence,
      correlation with serum cholesterol level and the role of
      laparoscopic cholecystectomy. Saudi Med J 2004; 25(9):1226-
      1228.

76.   Khairy GA. Challenges in creating the educated surgeon in the
      21st century. Where do we stand? Saudi Med J 2004; 25(9):1288-
      1289.

77.   Khalaf H, Al-Asseri A, Bhuiyan J, Nafea O, Al-Sebayel M.
      Tacrolimus (FK 506) given three times daily after liver
      transplantation for minimizing nephrotoxicity and neurotoxicity.
      Transplant Proc 2003; 35(7):2787-2788.

78.   Khan AR. Open laparoscopic access for primary trocar using
      modified Hasson‟s technique. Saudi Med J 2003; 24 Suppl 1:
      S21-S24.


                                 157
79.   Khan IA, El-Tinay OE. Laparoscopic cholecystectomy for acute
      cholecystitis. Can preoperative factors predict conversion? Saudi
      Med J 2004; 25(3):299-302.
80.   Khan IA, Noureldin OH, El-Bakry AA, Al-Saigh AA. Intestinal
      obstruction due to mesenteric panniculitis. J Coll Physicians Surg
      Pak 2003; 13(11):661-662.
81.   Mallick S, Al-Bassam A. Diaphragmatic eventration after chest
      tube placement in a neonate: case report and review of literature.
      Ann Saudi Med J 2003; 23(5):298-300.
82.   Mallick S, Nasrallah R, Al-Bassam A. Surgical management of
      severe peptic esophageal stricture in children. Saudi Med J 2003;
      24(5 suppl):S36.
83.   Neel KF. Spontaneous bladder rupture in a non-augmented
      neuropathic bladder. Saudi Med J 2004; 25(2):220-221.
84.   Rasool MN, Hawary MB. Benign eccrine peroma in the palm of
      the hand. Ann Saudi Med 2004; 24(1):46-47.
85.   Tashkandi M, Al-Qattan MM, Hassanain JM, Hawary MB, Sultan
      M. The surgical management of high-grade gynecomastia. Ann
      Plast Surg 2004; 53(1):17-20.
86.   Zahraa JN, Abu-Ekteish F, Al-Bassam AR, Nasir AA. Perforated
      Meckel's diverticulum in a neonate mimicking necrotizing
      enterocolitis. Pediatr Emerg Care 2003; 19(6):418-419.
ABSTRACTS AND PRESENTATIONS
1.    Al-Bassam A. Feminizing genital reconstruction: Experience with
      52 cases of ambiguous genitalia. 36th Annual Meeting of the
      Pacific Association of Pediatric Surgeons with Australian
      Association of Pediatric Surgeons, Sydney, Australia.
2.    Al-Bassam A. Neonatal gastrointestinal surgical emergencies. In
      Practical Neonatology Symposium, Hera Hospital, Mecca, Saudi
      Arabia.
3.    Al-Bassam A.      Recent advances in the management of
      Hirschsprung's disease. In the 2nd International Symposium on



                                  158
      Pediatric Gastroenterology, Hepatology & Nutrition. King Faisal
      Specialist Hospital & Research Center, Saudi Arabia.

4.    Al-Bassam A.          Two-port versus three-port laparoscopic
      appendicitis in children with uncomplicated anti-appendicitis. 11th
      Congress for Endosurgery in Children hosted by IPEG, Genoa,
      Italy.
5.    Al-Kattan K.   The role of surgery in the management of
      tuberculosis. The 7th Annual Meeting of the Arab Thoracic
      Association & The 2003 Annual Meeting of the Lebanese
      Pulmonary Society, Beirut, Lebanon, 9-12 October 2003.
6.    Al-Qattan MM. An approach to children with obstetric brachial
      plexus palsy and active external rotation of the shoulder
      (Abstract). Can J Plast Surg 2004; 12:101.
7.    Ashour M, Hajjar W, Essam M, El-Medany Y, Al-Kattan K. Intra-
      operative heparin release during lung surgery. 2nd EACTS/ESTS
      Joint Meeting, European Association for Cardio-Thoracic Surgery,
      Vienna, Austria, 12 October 2003.
8.    Bakir MB, Fouda M, Al-Saddique A, Esmat A, Sallam A. On-pump
      beating heart myocardial revascularization in "high risk patients".
      14th Scientific Session of the Saudi Heart Association, Al-Khobar,
      21-22 January 2003.
9.    Bakir MB, Fouda M, Al-Saddique A, Jalal A, Sallam A, Esmat A.
      Intraoperative radio frequency ablation of atrial fibrillation in
      patients with mitral valve disease. Abstract of the 15th Scientific
      Session of the Saudi Heart Association, Jeddah, 6-8 January
      2004.
10.   El-Watidy S.         Cervical foraminoplasty for spondylotic
      radiculopathy. King Saud University International Orthopedic
      Symposium – Current Orthopedic Practice. King Khalid University
      Hospital, Riyadh, 29-31 October 2002.
11.   El-Watidy S. Intersegmental decompression for acquired lumbar
      canal stenosis. King Saud University International Orthopedic
      Symposium – Current Orthopedic Practice. King Khalid University
      Hospital, Riyadh, 29-31 October 2002.


                                   159
12.   Esmat A, Bakir BM, Fouda M, Al-Saddique A, Sallam A. The
      aortic connector system: a novel approach to patients with
      calcified aorta in coronary artery bypass grafting. 14th Scientific
      Session of the Saudi Heart Association, Al-Khobar, 21-22 January
      2003.
13.   Hajjar W, Essa M, Al-Kattan K, Ashour M. Surgical management
      of bronchogenic cysts: 15 years experience. The 7th Annual
      Meeting of the Arab Thoracic Association & The 2003 Annual
      Meeting of the Lebanese Pulmonary Society, Beirut, Lebanon, 9-
      12 October 2003.
14.   Mallick S, Nasrallah R, Al-Bassam AA. Surgical management of
      severe peptic esophageal stricture in children. [Gastrointestinal
      Abstracts]. Saudi Med J 2003; 24 Suppl 1: S36.
15.   Neel KF, El-Faqih SR, De Castro R, Abu Dias JM, Al-Shammari
      AM. Presentation of posterior urethral valves in Saudi Arabia in
      the 90‟s: Are we meeting the expectations? [Genitourinary
      Abstracts]. Saudi Med J 2003; 24 Suppl 1: S48.
16.   Neel KF, Soliman SM, Al-Qarni A. Non-intubated vs intubated
      pyeloplasty in children – the KKUH experience. [Genitourinary
      Abstracts]. Saudi Med J 2003; 24 Suppl 1: S48.
17.   Neel KF. Endoscopic correction of complicated vesicoureteric
      reflux in children. [Genitourinary Abstracts]. Saudi Med J 2003; 24
      Suppl 1: S53.
18.   Sallam A, Bakir BM, Fouda M, Al-Saddique A, Jalal A, Esmat A.
      Cardiac surgery in elderly patients: a retrospective analysis of
      mortality and morbidity. Abstract of the 15th Scientific Session of
      the Saudi Heart Association, Jeddah, 6-8 January 2004.
19.   Soliman SM, Hafie E, Hassan TA, Hamza AF, Hay SA, Bassiouny
      IE. Hair coil induced penile tourniquet injury. [General Abstracts].
      Saudi Med J 2003; 24 Suppl 1: S55.
20.   Soliman SM. A naturally appearing glanular meatus after Mathiu‟s
      procedure combined with Snodgrass incision/hinge of the plate.
      [Genitourinary Abstracts]. Saudi Med J 2003; 24 Suppl 1: S50.




                                   160
                  AUTHOR INDEX
Abba AA, 120, 126                        Al-Ansary LA, 116
Abd-Allah AR, 143                        Al-Arfaj AS, 116, 121, 122, 125,
Abdel Aziz A, 106, 166, 170                 152, 156, 162
Abdelaziz EM, 106, 171                   Al-Arfaj H, 125
Abdel-Halim RE, 120, 130, 156, 166       Al-Arishi H, 148
Abdel-Hameed A, 142                      Alasaly K, 123
Abdel-Magid ME, 106,171                  Al-Asseri A, 173
Abdel-Magid TE, 166                      Al-Attas O, 125
Abdo AA, 120, 121, 124, 126              Al-Attas OS, 125, 134, 156
Abdu MA, 167                             Al-Ayadhi LY, 156
Abdul-Ghani H, 117                       Al-Bakry A, 163, 172
Abdullah AM, 126, 149, 150               Alballa SR, 116, 121, 122, 125,
Abdullah MA, 125                            152, 156
Abdulwahab AA, 130, 166                  Al-Bassam A, 150, 167, 174, 175,
Abid J, 121, 127, 142                       176
Abou-El-Ella KM, 121, 162, 166           Al-Bishi SM, 134, 136, 138
Abu Dias JM, 176                         Al-Boukai AA, 122, 162, 163, 172
Abu El-Asrar AM, 114, 134, 135, 136,     Al-Bubiey K, 123, 148
  137, 138, 156                          Al-Daghri, 125
Abu-Aisha H, 121, 127, 142               Al-Dalaan AN, 116, 121, 122, 152,
Abu-Ekteish FM, 148, 150, 174               156
Addar MH, 110, 123, 130, 131, 162        Al-Damegh SA, 162
Adetiloye VA, 162                        Al-Dayel F, 148
Ahmad HR, 158, 160                       Al-Diab IA, 122, 127
Ahmed N, 160                             Al-Dohayan A, 106, 171
Al-Abdulkareem A, 166                    Al-Dousary SH, 114, 162
Al-Akeely MH, 166, 167, 171              Al-Drees AZ, 127
Al-Akwa'a AM, 121, 124                   Al-Enazi AM, 170
Alam MK, 167, 171                        Al-Faleh FZ, 122, 124, 126, 127,
Al-Ammar AY, 114                            156
Alamoudi O, 124, 127                     Al-Faleh H, 138
Al-Amri SM, 121, 124                     Al-Faran M, 136
Al-Amro SA, 134, 135, 137,148, 156       Al-Faris EA, 116, 117
Al-Anazy AR, 144                         Al-Frayh AS, 145, 148, 150


                                   161
Al-Freihi HM, 124                    Al-Kattan K, 107, 150, 152, 170,
Al-Garni AA, 143                        171, 172, 173 ,175, 176
Al-Gayyar F, 121, 127, 142           Al-Kattan WM, 169
Al-Ghamdi AS, 124, 125, 126          Al-Khadra AH, 125
Al-Ghumlas AK, 156, 157              Al-Khalaf AK, 135
Al-Habeeb TA, 127                    Alkhalife IA, 142, 144
Al-Hakeem M, 130                     Al-Kharashi SA, 134, 135, 138
Al-Hakeem MM, 131                    Al-Kharfi TM, 135, 148
Al-Hamad AM, 123                     Al-Khattaf AS, 142, 144
Al-Hamdan N, 117                     Al-Kheir A, 123
Al-Harby SW, 107                     Al-Khlaiwi T, 157, 158
Al-Harthi SS, 125                    Al-Maatouq M, 123, 125, 130, 162
Al-Harthy MS, 120                    Al-Majed AA, 143, 145
Al-Hazmi M, 148                      Al-Mansouri S, 134
Al-Hazzaa HA, 123                    Al-Marzouk K, 125
Al-Hedaithy SS, 142, 144             Al-Mazrou AM, 145, 148, 150
AL-Hoqail IA, 112                    Al-Mazrou KA, 114, 162
Al-Hori I, 158                       Al-Mazrou YY, 125
Al-Howiriny T, 142, 143              Al-Mehaideb A, 148
Al-Howaikan AM, 123                  Al-Meshari AA, 123, 130, 131, 143,
Al-Humayyd MS, 122, 152, 156            157, 159
Al-Husain M, 148                     Al-Moallem M, 127
Al-Hussain M, 149,162                Al-Mobaireek KF, 148
Ali AT, 152,153                      Al-Mobeireek AF, 106, 120, 123,
Ali SA, 158,160                         124, 125, 127, 130
Al-Jabbari AW, 123, 143, 157         Al-Modovar E, 148
Al-Jadaan IA, 134                    Al-Mofada SM, 135, 148
Al-Jarallah AA, 150                  Al-Mofarreh MA, 124
Al-Jarallah AS, 148,150              Al-Mofleh IA, 121, 124, 125, 126,
Al-Jarie A, 148                         148, 162, 166
Al-Jebreen AM, 124                   Almogren A, 143
Al-Jeffri M, 117                     Al-Mobireek A, 125
Al-Jishi Z, 135                      Al-Mohsen I, 148
Al-Jumaah S, 148                     Al-Momen AK, 123, 128, 131, 143,
Al-Jumah AR, 123                        157, 158, 159
Al-Jumah M, 123,148                  Al-Momen RK, 116
                                     Al-Motowa S, 136


                               162
Al-Motrefi AA, 152, 170                 Al-Saleh SS, 116, 121, 122
Al-Mubarak HF, 125                      Al-Salloum AA, 149
Al-Mugeiren S, 125                      Al-Salman MM, 163, 172
Al-Mulhim F, 150, 172, 173              Al-Satli RA, 106, 124, 130, 166,
Almutawa J, 106, 124, 130                  170
Al-Nahedh N, 117                        Al-Saud S, 106, 171
Al-Nemri A, 150                         Al-Sebayel M, 170, 173
Al-Nowaiser NA, 116                     Al-Sebayel MI, 121, 162, 166, 170
Al-Nozha MM, 125, 126, 128              Al-Sedairy S, 145, 150
Al-Nuaim LA, 130, 166                   Al-Sekeit MA, 116, 121, 122
Al-Obeidan SA, 134, 138, 156            Al-Serhani AM, 114, 134
Alorainy IA, 114, 149, 162              Al-Shabanah OA, 143
Al-Otaibi AG, 135                       Alshahid AH, 140
Al-Otaibi FE, 143, 148                  Al-Shahid MS, 125
Alotaiby WM, 106, 171                   Al-Shahwan S, 123, 148
Al-Qahtani F, 149                       Al-Shamairi M, 125
Al-Qarni A, 172, 176                    Al-Shamairy MQ, 125
Al-Qattan MM, 167, 168, 169, 174        Al-Shammari AM, 176
Al-Quaiz J, 118                         Al-Sharif AM, 138
Al-Rabeah A, 117                        Al-Shedoukhy AA, 143
Al-Rajeh S, 123, 127, 148               Al-Shobaili RM, 117
Al-Rajhi AA, 136                        Al-Smayer SA, 121, 162, 163, 166,
Al-Rajhi AI, 136                           172
Al-Rashed AR, 149                       Al-Sofayon MS, 170
Al-Rashed RS, 124, 126                  Al-Sohaibani MO, 142, 143
Al-Rehaily AJ, 143                      Al-Sugair S, 125
Al-Rikabi AC, 143, 145                  Alsuwaida K, 125
Al-Rowais NA, 116, 117                  Al-Suwaidan SN, 112
Al-Ruhaimi K, 149, 162                  Al-Suwaine A, 145, 150
Al-Rukban MO, 117                       Al-Swayeh OA, 152, 153
Al-Saadi M, 163, 172                    Al-Tahami, 117
Al-Saddique AA, 106, 152, 169, 170,     Al-Tahan A, 123
   176                                  Al-Tahan AR, 127
Al-Saghier MI, 170                      Al-Taweel AA, 117
Al-Saghir AH, 125                       Al-Temi IN, 167
Al-Saigh AA, 174                        Al-Traif I, 123
Al-Salamah SM, 167, 170, 171            Al-Turki R, 134, 136


                                  163
Al-Tuwaijri AS, 120, 122, 152, 156,         Bakir MB, 106, 166, 170, 175, 176
   157, 158, 166                            Bakir TM, 145
Al-Uthaim S, 123,148                        Ballow AA, 128, 159
Al-Wakeel JS, 121, 125, 127, 128,           Bamgboye EA, 117, 120, 125
  142, 159                                  Bartlett WA, 125
Al-Wani B, 127                              Basha S, 125
Al-Wazzan A, 126                            Bassiouny IE, 176
Al-Zaben A, 123                             Bawazir SA, 126
Al-Zahrani M, 148                           Bayoumi NM, 128, 131, 159
Al-Zaid K, 117                              Beck PL, 120, 121
Al-Zamil F, 145, 148, 150                   Becker S, 117
Al-Zayed AH, 125                            Begum NN, 144
Alzeer AH, 125                              Bernard LA, 112
Alzoghaibi MA, 157                          Bhatt-Mehta V, 150
Alzoum M, 149, 162                          Bhuiyan J, 173
Aqeel AY, 150                               Bismar HA, 171
Arafah MR, 125, 126, 128                    Bokhari SS, 158, 160
Arian SA, 157                               Brault S, 136
Ashoor B, 117                               Bridges RJ, 121
Ashour M, 150, 152, 170, 172, 173,          Butler TJ, 159
  175, 176
Aslam M, 158                                Chaudhary IA, 138
Awada A, 123                                Chaves-Carballo E, 123, 148
Awadallah SA, 158                           Checchin D, 136
Ayoola EA, 126                              Clark P, 140
Azam MN, 127                                Codere S, 121
Azeem MA, 158                               Cunningham BB, 112
Azeri A, 117                                Custer JR, 150
Aziz S, 144
                                            Daba MH, 145
Baabad RA, 143, 148                         Daif AK, 126,127
Babay HA, 144                               Dashash NA, 124
Babay ZA, 110, 123, 130, 162                Davidson D, 140
Babay ZH, 123, 131, 143, 157                De Castro R, 176
Bahabri SA, 116, 122                        Delvi B, 171
BaHammam AS, 126                            Dralands L, 134, 135
Bain VG, 120                                Dura WT, 142


                                      164
Dzimiri N, 152                           Feldman SR, 112
                                         Fotedar R, 142, 144
Eichenfield LF, 112                      Fouda M, 106, 166, 170, 175, 176
Eid EE, 170                              Fouda MA, 126, 163, 169
El-Badawy RM, 126                        Fouda-Neel KA, 172
El-Bakry AA, 106, 107, 152, 170, 171     Fowler AA, 157
El-Bakry AA,166, 171, 172, 174
El-Dawlatly AA, 106, 107, 171            Gad A, 117
El-Desouki MI, 123, 126, 130, 162,       Gad El-Rab MO, 123, 131, 143,
  163                                     145, 150, 157
Eldin Magzoub M, 117                     Gader AM, 123, 128, 131, 134,
El-Faqih SR, 120, 156, 166, 176            143, 156, 157, 158, 159
El-Hazmi MA, 110, 130                    Gado A, 145,167
El-Hazmi MM, 144                         Gaurano JL, 163
El-Jack I, 116                           Geboes K, 134, 135
El-Kayali AA, 163, 171, 172              Ghonaim MA, 120
El-Medany AH, 152, 153                   Ghourab S, 130
El-Medany Y, 150, 172, 173, 175          Graham MF, 157
El-Mouzan MI, 126, 149                   Guraya SY, 173
El-Mubarak M, 157
Elsaegh MM, 169                          Habib FA, 131
El-Sharawy Y, 135                        Habib SS, 158
El-Sharkawy MS, 163                      Hafil E, 176
El-Shayeb A, 169                         Hagar HH, 152, 153
El-Tahir K, 142                          Haidara MA, 158
El-Tinay OY, 163, 172, 174               Hajjar W, 107, 150, 152, 170, 171,
El-Watidy S, 172, 175                      172, 173, 175, 176
Esmat A, 175, 176                        Hamza AF, 176
Essa M, 150, 152, 170, 172, 173,         Hariri Z, 150, 172
   176                                   Hashem FK, 169
Essam M, 175                             Hasnain SM, 145,150
                                         Hassan AA, 148
Faiz SA, 130, 131                        Hassan S, 130, 166
Fatani RA, 138                           Hassan TA, 176
Fathalla SE, 145                         Hassanain J, 169, 174
Fatima K, 145, 150                       Hawary MB, 174
Fawzy EM, 122                            Hay SA, 176


                                   165
Helmi A, 169                               Khoshhal KI, 140
Huraib SO, 121, 127, 128, 142, 159         Khuroo SS, 170
Husain A, 157                              Kichian K, 120
Husain SA, 125                             Klassen J, 120
                                           Kremli MK, 140
Ibrahim IM, 158                            Krowchuk D, 112
Iqbal K, 163,172                           Kumar S, 125
Ikerr MA, 143                              Kumo AM, 120
Isnani AC, 124                             Kurdi AM, 131

Jalal A, 173, 175, 176                     Lardhi AA, 148
Jamal Q, 157                               Le Quesa G, 148
Jammah AA, 125                             Lee SS, 120,126
Jarvis J, 140                              Letts RM, 140
Jesteneiah S, 114, 134                     Loomes LM, 143
Joharjy IA, 163
Jones AF, 125                              Mahgoub AA, 153
                                           Mahmoud M, 136
Kabbani MA, 170                            Mahmoud N, 123, 131, 143, 157
Kalantan KA, 117                           Majumdar R, 123, 148
Kambal AM, 143, 144, 145, 148, 150         Mallick MS, 174, 176
Kangave D, 134, 136                        Manaa EM, 106, 171
Kazmi KA, 160                              Mansour M, 145
Khairy GA, 173                             Mariam T, 160
Khalaf H, 170, 173                         Martin SC, 125
Khalaf HA, 170                             Martins J, 148
Khalaf M, 107                              Mattar KM, 126
Khalifa HM, 131                            Mattar EH, 123, 130, 162
Khalil MZ, 120, 125, 126                   Mayet IY, 126
Khalil NA, 131                             Medany Y, 107, 171
Khan AR, 173                               Meddings J, 120
Khan IA, 163, 172, 173, 174                Meersschaert A, 135
Khan MN, 158, 160                          Meo SA, 157, 158, 159, 160
Khan NB, 125                               Merifi N, 130
Khan ZA, 145                               Mesleh RA, 131
Khashoggi TY, 131                          Missotten L, 134, 135
Khoja TA, 116


                                     166
Mitwalli AH, 120, 121, 127, 128,         Rabee HM, 163, 172
   142, 156, 159, 166                    Raber E, 120
Mohamed ON, 121, 162, 166                Rafatullah S, 142, 143
Mohammed AA, 170                         Rafay MA, 173
Moler FW, 150                            Rahmatullah RA, 120
Mostafa AM, 143                          Ramia S, 121, 127, 142
Mousa MA, 116, 122                       Rasool MN, 169, 174
Mukhtar I, 140                           Reed JW, 159
Murshid KR, 171, 173                     Rehana Z, 123
Murtuza M, 163, 172                      Richardson MA, 114, 162
Mustafa AA, 122, 152, 156                Riyad W, 106, 171
                                         Rossi L, 148
Nafae OM, 170, 173
Naguib M, 107                            Saad SY, 145
Nainar SI, 131                           Sabah DM, 153
Najjar TA, 145                           Sabir S, 160
Nasrallah R, 174, 176                    Saidu AB, 144
Nasser AA, 150                           Saleemi SA, 123
Nassir AA, 148, 150, 174                 Salih M, 172
Neel KF, 174, 176                        Salih MA, 123, 148, 150
Noor M, 163, 172                         Sallam A, 175, 176
Nouh MS, 125                             Samah A, 106, 170
Noureldin OH, 163, 172, 174              Samarkandi AH, 106, 107, 166
                                         Sennlaub F, 136
Odetola FO, 150                          Serebour FE, 127
Olaiyan I, 148                           Senior BW, 143
Omar SA, 157                             Shahid K, 130
Osman A, 158                             Shah A, 127
Osman AK, 128                            Shah MH, 157
Osman E, 138                             Shaikh ZA, 157
Othman SA, 123, 130, 162                 Shakni L, 127
Othman SM, 126, 163                      Shakoor Z, 145
Premkumar LS, 152                        Shamena AR, 127
Pyrne N, 117                             Shehrani D, 148
                                         Shobokshi OA, 127
Qahtani A, 127                           Siddique N, 121
Qureshi NA, 127                          Siddiqui N, 122, 127


                                   167
Siddiq MM, 130                   Yousif KI, 121, 127, 142
Sogiawalla FF, 122
Soliman SM, 172, 176             Zahraa JN, 148, 150, 174
Splinter W, 140                  Zaidan R, 127
Sporrong BG, 130, 131            Zakaria FA, 152
Struyf S, 135                    Zamzam M, 140
Subhan MM, 158, 159, 160         Zamzami M, 140
Sultan M, 174
Swain MG, 120

Tabbara KF, 134
Takrouri MS, 107
Talal A, 171
Tarif N, 127
Tashkandi M, 174
Thabit AA, 135, 148
Thalaj A, 106
Turkistani A, 106
Twum-Danso K, 145, 150




Urbanski SJ, 120, 121

Valamanesh F, 136
Van Damme J, 135
Vasquez-Tello A, 136

Walsh SW, 157
Wani BA, 120, 126
Warsy AS, 110, 130
Willey A, 157
Wilson JK, 112

Yager DR, 157
Yaseen H, 158
Yeboah EA, 144


                           168