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Missouri Life Sciences

VIEWS: 5 PAGES: 69

									A.   Introduction
B.   National Industry Facts & Figures
C.   Missouri Life Sciences Industry Profile
     1.     Facts & Figures
     2.     Industry Profiles
D.   Missouri Organizations
     1.     Locations of Organizations
     2.     Research Institutes
            a.      Stowers Institute
            b.      Donald Danforth Plant Science Center
            c.      MU Life Sciences Center
            d.      KC Area Life Sciences Institute
            e.      Midwest Research Institute
            f.      BioBelt
     3.     Incubators
            a.      MAPUIC
            b.      Nidus Center for Scientific Enterprise
     4.     Other Organizations
            a.      Biotechnology Industry Association
            b.      St. Louis Regional Center and Growth Association
            c.      Technology Gateway Alliance
     5.     University Research Programs
     6.     Additional Research Institutes, Incubators, & Research Parks
E.   Major Related Companies in Missouri
     A.     Monsanto
     B.     Protein Technologies International
     C.     Mallinckrodt
     D.     Aventis Pharmaceuticals
     E.     Sigma-Aldrich
F.   Missouri Incentives
     1.     State Tax Policy
     2.     State Financing to Bioscience Companies
     3.     Networking and Support
     4.     State Regulatory Policy Brief
G.   Online Resources
H.   Federal Laws & Regulations
bi·o·tech·nol·o·gy
n.

1. The use of microorganisms, such as bacteria or yeasts, or
   biological substances, such as enzymes, to perform specific
   industrial or manufacturing processes. Applications include
   the production of certain drugs, synthetic hormones, and bulk
   foodstuffs as well as the bioconversion of organic waste and
   the use of genetically altered bacteria in the cleanup of oil
   spills.

2. The application of the principles of engineering and
   technology to the life sciences; bioengineering.
Biotechnology has been around for
years. Farmers have been practicing
the science of crop improvement for
over 75 years. However, a lot has
changed in these 75 years. Scientific
and technological advances now allow
humans to manipulate genomes
directly at the level of single genes and
their constituents with great speed and
precision.
The modern biotech sector is relatively
new, and a new industry name has
been proposed –Life Sciences.
Life sciences is an industry where biotechnology,
agriculture, food, drugs and chemicals converge.
Through the combination of these divisions, firms are
able to produce new research & products. Crops are
now being designed to produce feedstocks for plastics,
vaccines, and foods that help to prevent or ward off
disease.
Missouri has made significant strides in positioning itself for economic growth in the
life sciences. Since designating life sciences in 1999 as a lead industry for economic
development, Missouri has been pursuing a multi-faceted initiative aimed at growing
this industry, and ensuring that all regions of the state share in this growth.

The I-70 Biotech Corridor
stretches from Kansas City to
St. Louis. Fueled by world class
research institutions, nationally-
ranked teaching hospitals, and
corporate powerhouses in
biotech R&D, this corridor has
already displayed an ability to
create the kinds of high-tech
jobs that attract highly educated
young professionals. It is a
potential wealth generator for
the region far into the future.
Table From Biotechnology Industry Organization Website, http://www.bio.org/er/statistics.asp
               Top U.S. Ag Science Companies, sales (Millions)




Data from
www.inverizon.com
             Commercial Biotech Crop Acres in the U.S.




Data from www.inverizon.com
Data from
Data from
Data from
Data from
Industry Profiles          Industry Analysis
•Agri-Chemical             •Biotechnology
•Bio-Medical                   -Full Report (*.pdf)
•Equipment & Instruments   •Health Science Biotechnology
•Food & Nutrition              -Full Report (*.pdf)
•Industrial Chemical       •Agri-Chemical Industry
•Life Sciences Research        -Full Report (*.pdf)
Data from
Data from
Data from
Data from
Data from
Data from
                               The Health Science Biotechnology in Missouri report
                                   examines health science biotechnology as a
                                   subsector of life sciences. The purpose of the
                                   analysis is to determine the sector’s impact on
                                   Missouri’s economy.

                                                      KEY FINDINGS
                               •   Health science biotechnology employment is
                                   concentrated in the core metropolitan areas of the
                                   state. It appears that the metropolitan areas of St.
                                   Louis (City and County) and St. Joseph (Buchanan
                                   County) have high specialization in biotechnology
                                   employment.
                               •   In 1999, the health science biotechnology sector
                                   directly accounted for 1.05% of total GSP in Missouri
                                   ($1.60 billion). Indirect and induced economic effects
                                   attributable to this sector accounted for 1.01% of
                                   GSP ($1.55 billion). Taken together, the health
                                   science biotech sector directly and indirectly
                                   accounted for 2.07% of total GSP in Missouri ($3.15
                                   billion).
                               •   In 1999, there were 11,170 health science
                                   biotechnology sector jobs in Missouri, with an
                                   average wage of $74,014. This direct employment
                                   created an additional 32,736 ancillary jobs in the
  Click to Download the full       Missouri economy – for a total impact of 43,906 jobs
Health Science Biotechnology
                                   statewide.
      in Missouri report
                                                   More Key Findings
The health science biotechnology sector includes industries that
produce medical and botanical products; pharmaceuticals;
diagnostic substances; surgical, medical, and dental instruments
and appliances; medical and dental products; and ophthalmic
products.


                  Health Science Biotechnology SICs
Specialization Ratios (SRs) are used to describe the dispersion of the
biotech sector across Missouri. SRs measure a county’s employment
concentration in a given economic sector relative to the state average.
SRs are useful because they indicate areas of potential economic
growth within the county, or a county’s comparative advantage in a given
sector. Comparing these ratios over time gives an indication of the
relative strengths and weaknesses of the biotech sector




Refer to page 2 of the Health Science Biotechnology in Missouri Report
for more information on Specialization Ratios
  Biotechnology Employment Specialization Ratios




Specialization Ratios                 NOTE: Biotechnology sector
       High Specialization            includes medicinal and botanical
       (SR > 1.5)
       Above Average Specialization   products; pharmaceuticals; in
       (SR = 1.05 - 1.5)              vitro and in vivo diagnostics;
       Average Specialization         biological products; surgical and
       (SR = 0.95 – 1.05)             medical apparatus orthopedic
       Below Average Specialization   and surgical appliances; dental
       (SR = 0.5 - 0.95)
       Low Specialization             equipment; and ophthalmic
       (SR < 0.5)                     goods.
In Missouri, the ten largest firms are located in the metropolitan areas
of the state, with over half the firms located in the St. Louis
metropolitan area.
                                              Columbia
                                              •MU Life Sciences Center
                                              •MAPUIC
                                              •University of Missouri-
                                              Columbia

Kansas City                                                 St. Louis
•Stowers Institute                                          •Danforth Plant &
•KC Area Life                                               Science Center
Sciences Institute                                          •BioBelt
•Midwest Research                                           •Nidus Center for
Institute                                                   Scientific Enterprise
•University of Health                                       •St. Louis RCGA
Sciences
                                                            •Technology Gateway
•UMKC                                                       Alliance
                                                            •Washington University
                                                            •Center for Emerging
                                                            Technologies
   Research Parks                                           •St. Charles County
 St. Charles,                                               Synergy Center
                        Missouri Enterprise
 Columbia, & Ft.
                        Business Assistance
 Leonard Wood
                        Centers
The Stowers Institute for Medical
Research, located in Kansas City, aspires
to be one of the most innovative biomedical
research facilities in the world. The
Institute conducts basic research into
complex genetic systems to unlock the
mysteries of disease and find the keys to
their causes, treatment and prevention.
It was founded by Jim and Virginia
Stowers, two cancer survivors who decided
to dedicate their fortune to supporting the
basic research that will provide long-term
solutions to gene-based diseases.
The Stowers Institute is located on a 10-
acre research campus, including a
600,000-square-foot complex to house
laboratories, research support facilities,
animal resource center, administration, and
maintenance.
     http://www.stowers-institute.org/
The Stowers Institute opened its doors to
the first scientific research teams in
November 2000 after completion of its $200
million, state-of-the-art research facility in
Kansas City, Missouri. The Institute is
supported by endowments that currently
total about $1.65 billion.
The Stowers Institute is bringing scientists
from many disciplines together to focus on
analyzing how genes and proteins control
cell multiplication, differentiation, migration,
and death in the context of early
development of organisms. This, along with
their commitment to develop and use the
latest in technology, will allow them to create
an intellectual environment in which
questions of fundamental importance to
biology and medicine can be answered.

     http://www.stowers-institute.org/
• Unique and innovative partnership joining:
   Missouri Botanical Garden
   Monsanto Company
   Purdue University
   University of Illinois at Urbana-Champaign
   University of Missouri-Columbia
   Washington University in St. Louis
   St. Louis-based Danforth Foundation
   State of Missouri.




                    http://www.danforthcenter.org/
      All Human Life Depends On Plants

    Leaders of a Plant Science Revolution
Increase understanding of basic plant biology

Apply new knowledge to help sustain productivity in
agriculture, forestry and allied fields

Facilitate the rapid development and commercialization of
promising technologies and products

Contribute to the education and training of graduate and
postdoctoral students, scientists and technicians from around
the world.




     http://www.danforthcenter.org/
The MU Life Sciences Center
(LSC) is a $60 million project
with 124,000 net square feet
which includes 50 research
laboratories, multipurpose
equipment rooms, five
teaching/computer laboratories
and a 250-seat auditorium. The
state-of-the-art research/teaching facility is designed to provide
flexible space to maximize interactions and foster interdisciplinary
team research.

The project is on track to start construction Fall 2001. The site is
at the corner of Rollins Road and College Avenue on the MU
Campus. The targeted date for completion of construction is
Spring 2004.
For more information about the center, visit the UMC Life Sciences Center Website….


  •LSC Mission: A Vision for the Future
  •Support for the Life Sciences Center
  •Why MU?
  •Benefits to Missourians & the World
  •View the Inside of the Center




             Click for more information…




                                             http://lifesciences.missouri.edu/lscenter.htm
•       Not-for-profit corporation that has been established to implement a strategy to foster
        collaboration and resource sharing between the area’s private sector, academia, and
        government
•       Founded jointly by the Civic Council of Greater Kansas City and the Kansas City Area
        Development Council
•       Mission: assisting with the transformation of Kansas City into a center for excellence in life
        sciences research and development.




    CORE ENABLING TECHNOLOGIES
    •    Genomics
    •    Proteomics
    •    Information technology/bioinformatics
                                                                     RESEARCH FOCUS
    •    Imaging
                                                                 •   Cancer
    •    Analytical sciences
                                                                 •   Human development and
                                                                     aging
                                                                 •   Cardiovascular diseases
                                                                 •   Infectious diseases
        http://www.kclifesciences.org/
                                                                 •   Neurological diseases
The Midwest Research Institute conducts
research for developing, distributing, using, and
detecting genetically modified organisms. This
involves:

     •DNA assays
     •Analysis of expressed proteins
     •Comparisons of seed lots
     •Detection of mutations and hybrids

MRI's biotech expertise includes collecting and identifying plant and animal
pathogens, as well as developing cultures and performing food safety research
such as:

      •Food contamination
      •Mycotoxins
      •Environmental microbiology


http://www.mriresearch.org/Markets/Agriculture/biotechnology.htm
The Gateway to the West has become the Gateway to the Future
The St. Louis region IS the BioBelt
 – World-class center for plant and life sciences research, investment
   and business opportunity.
 – Most noteworthy areas of strength are:
    • genomics and gene sequencing
    • Neuroscience
    • Cardiology
    • virology/microbiology/ immunology
    • plant sciences
    • tropical botany
     • biomedical engineering.


                       http://www.biobelt.org/
Established corporate leaders like Monsanto, Sigma
Aldrich and Mallinckrodt continue to build on the
foundations they have laid over many decades. In
addition to these leading companies there are a large
number of educational institutions, scientific organizations,
business groups and trade associations that are the
dynamic infrastructure of the BioBelt.
Researchers in the BioBelt are leading the charge to
unlock the mysteries of the human genome and are
providing answers on everything from HIV/AIDS to water
pollution cleanup.
The BioBelt brand is the first step toward fulfilling this
strategy: establishing a strong branding effort to define the
St. Louis region and its unique characteristics among
world plant and life sciences centers.
What is MAPUIC?                             MAPUIC Objectives

The Missouri Agricultural Product           MAPUIC identifies promising technologies and
Utilization and Incubation Center is a      innovations with application to agricultural,
research center that provides specialized   food, and industrial uses and facilitates their
technical assistance to enable              intellectual and business development.
agricultural entrepreneurs (individuals,    MAPUIC specializes in:
farmer groups, and agribusinesses) to
capture value from agricultural                  •Technology Assessment
innovations and to expand the utilization        •Technology Development
of Missouri’s agricultural products.             •Business Development




               http://www.emac.missouri.edu/mapuic/index.htm
         Established to assure the commercial success of
         start-ups and early stage life science companies.
         Unique business incubator that provides high value-
         added services and resources to its clients.
         Established relationships with national and
         international venture capital firms to facilitate access
         to seed and early stage capital which are critical
         factors in the success of companies.
                                   http://www.niduscenter.com/




Nidus Center for Scientific Enterprise is a non-profit, 40,000-
square-foot plant and life sciences incubator in St. Louis.
• National Organization with state affiliates
  in 31 States and numerous foreign
  countries

• Missouri Biotechnology Association
  (MOBIO)
   – Statewide membership organization that
     provides a legislative focus, educational
     initiatives, and networking opportunities for the
     biotechnology/life sciences industry in Missouri.
   – 120+ members

                 http://www.bio.org
•   Chamber of commerce and economic development organization for:
     –   St. Louis City; the Missouri counties of St. Louis, St. Charles, Lincoln, Warren, Franklin,
         and Jefferson; and the Illinois counties of St. Clair, Jersey, Madison, Clinton and Monroe.
•   4,000 member companies constitute nearly 40% of the regional workforce
•   Parent of Technology Gateway Alliance
•   Originator of Biobelt website




                                   http://www.stlrcga.org/
•   St. Louis Regional Science and Technology Alliance
     – part of the St. Louis Regional Chamber and Growth Association
•   Mission: position Greater St. Louis as America's Center for Technology



                                                        BENEFITS
                                              •   Bringing together businesses,
                                                  universities and government
                                                  officials to advance the
                                                  technology industry in the St.
                                                  Louis region.
                                              •   Making the region more attractive
                                                  to recruit and retain scientists,
                                                  engineers and other technology
                                                  professionals.
                                              •   Sharing lessons learned with
                                                  other technology leaders.




                  http://www.technologygateway.org/
The University of Health Sciences,
Kansas City



University of Missouri-Kansas City



Washington University,
St. Louis




University of Missouri-Columbia
Specialized Biotechnology Incubators
     Center for Emerging Technologies, St. Louis
     St. Charles County Synergy Center, St. Louis


The following University of Missouri research parks offer accommodations for bioscience
companies, although they are not targeted exclusively to bioscience companies:
     Missouri Research Park, St. Charles
     University of Missouri Technology Park, Ft. Leonard Wood
     University of Missouri Research Park, Columbia


Business Development Support. Missouri's four innovation centers provide a wide range of
management and technical assistance during the early stages of development for new technology-
based business ventures. They can, also, provide physical space with necessary support in their
business incubators.
     Center for Emerging Technologies, St. Louis
     Missouri Enterprise Business Assistance Center, Rolla & Springfield
     Missouri Innovation Center, Columbia
     Center for Business Innovation, Kansas City
•Research Tax Credit to qualified corporations or individuals. Credits
can be carried forward 5 years.
•Tax credits for R & D equipment.
•Exemption of state or local sales or use tax exemption for life science
companies.
•Tax credits are available for investors in start-up companies.
•Missouri DED provides tax credits for companies that locate in
enterprise zones.
•CAPCO, Certified Capital Companies Sections, provide venture capital
funding for biotechnology companies.
•The New Enterprise Creation Act will allocate $20 million in tax credits
over the next four years to contributors to seed capital and tart up
capital funds. Contributors will be awarded a tax credit equal to 100%
of their contribution.
Centers for Advanced Technology (CATS) Program
•The state of Missouri helps industries pay for research contracted
through a state university.
•Funded projects are expected to result in either reduced production
costs, increased sales, or additional investment in the company


Prolog Fund
• Public-private $40 million fund authorized by the Missouri New
Enterprise Creation Act.
• Fund for early stage capital
• Prepared to make investments in biotech/life sciences companies
Missouri Technology Corporation (MTC)
•Dedicated to creating a stronger Missouri economy by developing
science and technology; promoting business modernization through
transfer of science, technology, and quality improvement methods;
and enhancing the productivity of Missouri business.
Governor’s Life Sciences Roundtable
• Statewide forum to provide communication and support for life
sciences initiatives.
Missouri Biotechnology Industry Organization (MO-BIO)
•Statewide membership organization that provides a legislative
focus, educational initiatives, and networking opportunities for the
biotechnology / life sciences industry in Missouri
Missouri has enacted genetic privacy legislation


Missouri has not enacted “right to know” legislation


Missouri has not enacted legislation to place price controls on
prescription drugs


Medicaid Reimbursement Policy: Missouri has an open
formulary with prior authorization required for specific drugs
Chesterfield Research Center
The Chesterfield Village facility opened in
1984 to provide high-quality research
facilities for Monsanto's new biotechnology
and developing agriculture research efforts.
The buildings include a little over one million
square feet of research space.
The facility currently houses more than
1,300 scientists working primarily on
agricultural and pharmaceutical research.

Creve Coeur Campus
The Creve Coeur Site is 504 acres, 68
acres of which are developed (including
15.3 acres of building space and 52.7 acres
of roads and lots). The remaining 436 acres
are lawns and wooded areas.
The World Headquarters of Protein
Technologies is in St. Louis. Protein
Technologies, a DuPont Business, is a
worldwide leader in the research,
manufacturing and marketing of high-quality,
soy-based ingredients and ingredient
systems. Their products include: soy
polymers and coatings, isolated soy protein,
soy fiber, and ingredient systems.
Founded in 1967 as a research-intensive
division of Ralston Purina Company, Protein
Technologies International dedicated
considerable resources to generate new
product developments for the industry of soy
protein.
Based in St. Louis, Mallinckrodt
manufactures and markets medical
products. Their products include:
pharmaceuticals, respiratory equipment,
and imaging systems. The corporate
headquarters are located in Hazelwood
and Mallinckrodt has corporate offices
in Chesterfield as well.
North America Industrial Operations
Headquarters for Aventis Pharmaceuticals is in
Kansas City, with a manufacturing site located
there as well. Allegra, Allegra-D and Carafate
are just a few of the medicines produced by
Aventis. These sites are focused on
sustained-release technology, direct-
compression tablets, high-intensity granulation,
fluid-bed granulation, wurster coating, wax
matrix, dry compaction, liquid, creams,
tablets/capsules, and blister packaging.
Aventis Pharmaceuticals focuses on important
therapeutic areas such as cardiology,
oncology, infectious diseases, arthritis,
allergies and respiratory disorders, diabetes,
and central nervous system disorders.
Sigma-Aldrich develops, manufactures
and distributes the broadest range of high
quality bio-chemicals, organic chemicals,
chromatography products and diagnostic
reagents available in the world. The
Company's products are used in high-tech
research and development in universities
and industry, in the diagnosis of disease,
and as specialty chemicals for
pharmaceutical and other manufacturing
purposes.
                 Web Pages
Biotechnology    Forestry & Other           Renewable
& Agriculture   Biomass Resources           Bioproducts




                 Documents
                (click to download *.pdf)
Biotech Corn Resources
             Missouri Soybean
             Association



Useful Information:

    Soybean experts from business and
    research give their take on the future of
    the biotechnology

    Biotechnology Q & A
Three agencies are primarily responsible for
regulating biotechnology in the United States:

   •United States Department of Agriculture (USDA)
   •Environmental Protection Agency (EPA)
   •Food and Drug Administration (FDA)




Products are regulated according to their intended
use, with some products being regulated under more
than one agency.
             U.S. Department of Agriculture

Within USDA, the Animal and Plant Health Inspection Service (APHIS) is
responsible for protecting US agriculture from pests and diseases. Under
the authority of the Federal Plant Pest Act, APHIS regulations provide
procedures for obtaining a permit or for providing notification, prior to
"introducing" a regulated article in the United States.

      Useful Link   Relevant USDA Laws & Regulations

Products Regulated:        plant pests, plants, veterinary biologics

Web Sites:                 http://www.aphis.usda.gov/biotech

Contact Information:       Biotechnology Staff
            U.S. Environmental Protection Agency

EPA ensures the safety of pesticides, both chemical and those that are produced biologically.
The BioPesticides and Pollution Prevention Division of the Office of Pesticide Programs (OPP)
uses the authority of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) to
regulate the distribution, sale, use and testing of plants and microbes producing pesticidal
substances. Under the Federal Food, Drug and Cosmetic Act (FFDCA) EPA sets tolerance
limits for substances used as pesticides on and in food and feed, or establishes an exemption
from the requirement of a tolerance.

EPA also establishes tolerances for residues of herbicides used on novel herbicide-tolerant
crops.

Under the authority of the Toxic Substances Control Act (TSCA), EPA's TSCA Biotechnology
Program regulates microorganisms intended for commercial use that contain or express new
combinations of traits. This includes "intergeneric microorganisms" formed by deliberate
combinations of genetic material from different taxonomic genera.


      Useful Link      Relevant EPA Laws & Regulations
          U.S. Environmental Protection Agency
          (continued)



Products Regulated:
microbial/plant pesticides, new uses of existing pesticides, novel
   microorganisms

Web Site:
http://www.epa.gov/opptintr/biotech/

Contacts:
Office of Prevention, Pesticides and Toxic Substances
Office of Pollution Prevention and Toxics TSCA Biotechnology Program
BioPesticides and Pollution Prevention Division (BPPD)
                  U.S. Food & Drug Administration

As a part of the Department of Health and Human Services, FDA
   regulates foods and feed derived from new plant varieties under the
   authority of the Federal Food, Drug, and Cosmetic Act. FDA policy is
   based on existing food law, and requires that genetically engineered
   foods meet the same rigorous safety standards as is required of all
   other foods. FDA's biotechnology policy treats substances
   intentionally added to food through genetic engineering as food
   additives if they are significantly different in structure, function, or
   amount than substances currently found in food. Many of the food
   crops currently being developed using biotechnology do not contain
   substances that are significantly different from those already in the
   diet and thus do not require pre-market approval. Consistent with its
   1992 policy, FDA expects developers to consult with the agency on
   safety and regulatory questions.

   Useful Link   Relevant FDA Laws & Regulations
                U.S. Food & Drug Administration
                (continued)


Products Regulated:
food, feed, food additives, veterinary drugs, human drugs,
and medical devices

Web Sites:
List of Completed Consultations on Bioengineered Foods

Contacts:
Center for Food Safety and Applied Nutrition (CFSAN)

								
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