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Innovation in Action

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					Innovation in Action
  Strategic Collaborations with The University of
            Manchester’s Faculty of Life Sciences



              www.manchester.ac.uk/fls
Contents
Page 3
Introduction to The University of Manchester
Page 4-5
Building Strategic Partnerships
Page 6-7
Life Sciences at Manchester
Page 8-17
Our Research Capability: Themes
8-9 Genomics and Bioinformatics
10-11 Biomolecular Structure and Function
12-13 Cell, Tissue and Organism
14-15 Molecular Basis to Disease
16-17 Neuroscience and Vision

Page 18-19
Commercialisation of Life Sciences Research

Page 20-21
Recruiting Talent
Page 22-23
Developing Talent
Page 24-25
Working with Communities: Sharing Values

Appendices
Page 26-27
A. About The University of Manchester
Page 28
B. Business, Careers & Community Division
Page 29
C. Interdisciplinary Centre of Excellence
Page 30
D. Current Industrial Partners
Page 31
E. Key Contacts
                                                                                                                                                 3
                                                                                                                              Innovation in Action
                                                                                                    Strategic Collaborations with The University of
                                                                                                              Manchester’s Faculty of Life Sciences




                                               Manchester was the world’s first ‘industrial city’ and has always been a prodigious
                                               source of pioneers and innovators. It was the city which led the mechanisation of
                                               industry in the late 18th and early 19th centuries, and where Rolls met Royce in 1906,
                                               to create the Rolls-Royce company. It was where Nobel Laureate, Ernest Rutherford,
                                               undertook the pioneering work that led to the splitting of the atom in his University
                                               laboratory on Coupland Street. In the 1940s, also in Manchester, Tom Kilburn produced
                                               the first electronic computer, a breakthrough based on work undertaken in the Victoria
                                               University of Manchester. The city’s innovative spirit has always been equally evident
                                               in the arts, in the professions and in politics.




Dynamic cities host world class universities. This great ‘capital      subjects, established key priorities for inter-disciplinary
of the North’ is no exception. Embedded in the pioneering              research in areas of science and technology at the cutting
culture of the city, virtuoso research and profoundly influential      edge of progress in industry and commerce, and set a target
discoveries have emerged from universities able to command             to more than double the volume of research activity we do in
respect around the world.                                              collaboration with external partners.

The Victoria University of Manchester and UMIST, both formed           The University is pursuing this agenda in the context of the
in the first half of the 19th century, now bring rich legacies of      city of Manchester’s dramatic regeneration over the past 20
achievement to the new University of Manchester. Throughout            years. The aim is to make the world’s first industrial city a
their respective histories, both have been strong in life sciences.    great post-industrial city. A vibrant culture of creative industries,
This key discipline, which underpins modern bioindustry, is now        entrepreneurs, and technology-based start-ups is served by
even more vital to economic and social progress than ever              iconic buildings and a re-modelled city centre – and now by a
before. The new University of Manchester aims to build further         powerful, consolidated research university! The University
on its strength in these fields, and to develop strong partnerships    has extensive business incubation facilities and is a partner
with Government bodies and with leading science and                    in the nearby Manchester Science Park. The second biggest
technology-intensive companies worldwide. This is the mission          international airport in the UK has direct flights to major
of our Faculty of Life Sciences, one of the four faculties of the      destinations around the world.
University.
                                                                       Few city-regions in Europe have more potential than Manchester
On October 1st 2004, The University of Manchester, created as          to concentrate world class research and education in science
a result of the merger, became the largest in the UK, with an          and technology. In the coming years we look forward to
income of £500M, more than 30,000 students and over 8,000              welcoming the very best staff, students and industrial partners
staff. We have used the golden opportunity of its creation,            from around the world.
and a £250M capital programme to plan nothing less than a
revolutionary agenda. We have modernised management                    Professor Alan Gilbert
and administration, made long term academic plans for all              President and Vice-Chancellor
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Building Strategic Partnerships




                                The vision of the new University is to create an academic powerhouse in Manchester
                                whose international recognition and academic performance places it unambiguously
                                among the world’s greatest and most influential universities.




                            To achieve this vision, the Faculty of Life Sciences will work closely, and in a strategic manner, with a select group
                            of partners from the commercial world.

                            The relationships between companies and universities are many and complex, involving a range of activities to
                            enable companies to:
                            • both commission and participate as collaborative partners in research projects of mutual interest;
                            • access the specialist research facilities and resources of the University as well as the expertise of the staff of
                              the University, through formal and informal consultancy arrangements;
                            • work in partnership with the University on the development and commercial exploitation of intellectual property;
                            • replenish their staff complement through recruiting the best of the University’s graduates;
                            • develop theand through secondment of company staff to contribute to the research and teaching of the University;
                              University,
                                           skills and expertise of their staff, through continuing professional development conducted by the


                            • address, in collaboration with theand especially young women, to takeof relevanceintobioscience. such as
                              encouraging more young people,
                                                                   University, social and political issues
                                                                                                           up careers
                                                                                                                        both partners,


                            In the past, activities in pursuit of these various goals have often been carried out in an uncoordinated way, with
                            different parts of the collaborating organisations working almost autonomously to satisfy their locally identified
                            needs. There is a growing recognition, both by companies with a long track record of working with universities,
                            and by the leading universities, that such a piecemeal approach fails to maximise the benefits of collaboration.
                            A greater synergy can be achieved by fostering and capitalising on a comprehensive overview of all facets of the
                            complex relationship between company and university. Further, by taking a long-term view of the development
                            of a strategic partnership, the two organisations can develop a common and increasingly profound understanding
                            of their respective needs and aspirations, and processes can be put in place to reduce the bureaucratic overhead
                            associated with collaboration, leading to a more efficient and effective partnership.
                                                                                                                                                     5
                                                                                                                                  Innovation in Action
                                                                                                        Strategic Collaborations with The University of
                                                                                                                  Manchester’s Faculty of Life Sciences




The new University of Manchester is committed to developing and maintaining exemplary relationships with its
partner companies, building on the track record of UMIST and The Victoria University of Manchester, both of
which worked closely to mutual benefit with the commercial sector. The academic organisation of the University
features four Faculties (Life Sciences, Medical and Human Sciences, Engineering and Physical Sciences and
Humanities), each of significant size and each led by a Vice-President and Dean. In common with the other
Faculties, Life Sciences has professional staff, led by the Associate Dean for Communication and External Affairs,
to develop and manage its relationships with companies.

To facilitate, co-ordinate and promote links across the University, two Vice-Presidents (Innovation and Economic
Development; External Relations) have been appointed, supported by an External Relations Directorate, and a
Business, Careers & Community Division (BCCD). Within BCCD, a Business Development Unit has been set up
to support the development of long-term relationships with the private, public and voluntary sectors and to
ensure we respond holistically to business needs.

The Faculty of Life Sciences fully shares the new University of Manchester’s enthusiasm for productive collaboration
with industry and commerce. We recognise that the commercial sector is varied and that each company has
particular objectives and requirements. We understand that these objectives may include access to biotechnology,
staff development, provision of graduates or high quality data from specific projects. Our approach to collaboration
is therefore flexible and adaptable, with our primary objective being to put in place the most productive relationships:
some will have tightly defined targets but others will be broadly based around long-term, multi-faceted strategic
goals. I welcome all enquiries of interest from potential partners who share our vision.

Professor R. Alan North FRS
Vice-President and Dean
Faculty of Life Sciences
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Life Sciences at Manchester




                                Our mission is to make the Faculty of Life Sciences, already an internationally
                                distinguished centre of research, innovation, learning and scholarly inquiry, one
                                of the leading biosciences faculties in the world by 2015.




                            These are exciting times for life sciences in Manchester. On 1 October 2004, the new Faculty was formed by
                            a coming together of academics and researchers in the biosciences from two universities. The University of
                            Manchester Institute of Science and Technology (UMIST) contributed its Departments 0f Biomolecular Sciences
                            and of Optometry and Neuroscience. The Victoria University of Manchester contributed its School of Biological
                            Sciences and the Centre for the History of Science, Technology and Medicine. With 800 staff (including 250
                            academics and research fellows), 400 postgraduate and 1,500 undergraduate students, and a total budget of over
                            £100M, we are already one of the largest life sciences faculties in Europe.

                            Our mission statement sets out our agenda for building on our existing strengths to become a premier international
                            Faculty, routinely regarded by those equipped to judge as one of the leading biosciences centres in the world.
                            To achieve our objectives we are appointing the most capable academic and research staff and we are providing
                            those individuals with the facilities and environment that they need to be successful. Barriers to collaboration have
                            been removed. We therefore take advantage of our size to provide a highly interactive research environment which
                            allows Faculty members to broaden their research efforts. Our research is enhanced further by close links with the
                            other Faculties (Medical and Human Sciences, Engineering and Physical Sciences, and Humanities).

                            As a result of major capital investment by The University of Manchester, all members of the Faculty of Life
                            Sciences will work in new, purpose-built laboratories. Principal among these is the Michael Smith Building, a
                            £39M research facility which opened in 2004 and now accommodates the Faculty’s molecular cell biology
                            research groups. These include the Wellcome Centre for Cell Matrix Research, the UK Centre for Tissue
                            Engineering and the North West Institute for Bio-Health Informatics. The £35M Manchester Interdisciplinary
                            Biocentre (MIB), opening in July 2005, will contain a further 500 staff, including chemists, physicists, engineers
                            and mathematicians, who together will focus on quantitive biosciences such as structural analysis, proteomics,
                            metabolomics and systems biology. The MIB will house the UK Centre of Excellence in Biocatalysis,
                            Biotransformations (Bioprocessing) and Biomanufacture as well as one of the National Centres for Text Mining.
                            Research crossing the traditional subject boundaries will also be the mission of the Institute of Neuroscience
                            Research, which will bring together over 40 research groups addressing major questions about the function of
                            the nervous system in health and disease. The Institute will be located in a new £40M building that is
                            currently being designed.
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                                                                                                                               Innovation in Action
                                                                                                     Strategic Collaborations with The University of
                                                                                                               Manchester’s Faculty of Life Sciences




Commercial exploitation of the Faculty’s research activities will be driven by a new £27M Core Technology Facility,
(CTF) which will provide integrated space in which young businesses will work alongside university research groups.
The CTF will be located adjacent to the Manchester Incubator, the Faculty’s biotechnology research and development
centre, which houses 16 turn-key research laboratories equipped with all the infrastructure that a fledgling
biotech business requires to hit the ground running.

Within these buildings we operate a seamless management system, in which all researchers feel part of a single,
unified Faculty, rather than being split into divisions separated by administrative barriers. We encourage
collaboration between research groups and our strong internal communication system ensures that researchers
identify opportunities for joint initiatives with colleagues. We support our younger members of staff and we
reward success.

Each of the four departments which merged to form the Faculty of Life Sciences was graded 5 or 5* in the
national Research Assessment Exercise held in 2001, indicating that, in the eyes of the UK Government, the
greater part of the research carried out in the Faculty is already of international standing. Over the next decade,
we aim to place ourselves alongside the foremost biosciences universities of North America, Europe, the Far East
and Australasia. This an exciting and challenging goal but one that we are confident of achieving.

Professor Terry Brown
Associate Dean for Communication and External Affairs
Faculty of Life Sciences
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Our Research Capability: Themes



Our Capability – Genomics and Bioinformatics
Technology Platform

• Biomoleculeprotein sequencing Facilities
  s DNA and
              Synthesis and Analysis                                 • Systems Biology modelling of complex biological systems
                                                                       s Mathematical
    s Peptide and nucleic acid synthesis
                                                                     • Structural Bioinformatics peptide structure and stability
• Microarray Facilities robotics
  s PCR/liquid handling
                                                                       s Modelling of alpha-helical
                                                                       s Modelling protein interactions
    s Laser scanning image acquisition systems                         s Prediction of protein function
                                                                       s Analysis of vibrational spectroscopy data
• Proteomics
  s Protein separation technologies
                                                                       s Development of new algorithms for structural bioinformatics
                                                                       s Computation of changes in proton and electron affinities
    s MALDI-TOF spectrometry                                             involved in energy transduction by membrane proteins
    s Biocomputation and computer graphics
                                                                     • Large Scale Data Handling and Analysis storage, access and
• Forensicrecovery from forensic material
  s DNA
           DNA                                                         s Novel information technology for the
                                                                         analysis of sequence and functional genomic data
    s Sex identification                                               s GIMS (Genome Information Management System), an
    s Genetic profiling                                                  object-oriented data warehouse for sequence and functional
                                                                         genomics data
                                                                       s PRINTS, the world’s largest manually annotated protein
Research Expertise                                                       family database
                                                                       s TAMBIS, the first bioinformatics system to integrate
• Genome and EST Sequence Analysis                                       disparate, heterogeneous information sources
                                                                       s Biological text mining
• Transcriptome Analysis methods to ‘reverse engineer’
  s Probabilistic graph theory
                                                                       s Information visualization

      data on gene networks from time-series microarray data
    s MaxD microarray analysis software, fully compliant with the
                                                                     • Phylogenetics, Phylogenomics and Genome Evolutionof
                                                                       s Methodologies for the automatic creation and use
      emerging international standards                                   ontologies within well-defined areas of post-genome
                                                                         biological research
• Proteomics bioinformatics tools for mass spectrometry-based
  s Improved
                                                                       s Phylogenetic analysis of viral evolution, in particular
                                                                         focusing on HIV and AIDS
      proteomics                                                       s Network methods for analysis of gene families
    s Development of quantitative proteomics for malaria parasites     s Bioinformatics to study protein structure and relate
    s Global studies on protein turnover in yeast                        structural constraints to protein evolution
                                                                       s Mechanism of speciation in Saccharomyces yeasts
• Functional Genomicsinformatic approaches
  s Experimental and
                                                                       s Molecular population genetics of mosquitoes and
                                                                         biodiversity in Southeast Asia
    s Systematic analysis of gene function in the yeast                s Origins and evolution and domesticated crops
      Saccharomyces cerevisiae, in Aspergillus fungi and
      Streptomyces bacteria
    s Use of yeast as a vehicle to uncover the functions of human
      genes by employing a novel transcomplementation approach

• Metabolomics for revealing the functions of apparently
  s Novel strategies
      silent genes
                                                                                                                                                  9
                                                                                                                               Innovation in Action
                                                                                                     Strategic Collaborations with The University of
                                                                                                               Manchester’s Faculty of Life Sciences




Facilities of particular interest are:

The Consortium for the Functional Genomics of Microbial Eukaryotes (COGEME), which is funded by the BBSRC,
brings together a group of UK universities (Manchester, Kent, Aberdeen, Oxford, Bristol, IACR) which aim to
establish national, state-of-the-art facilities for the analysis of the transcriptome and proteome of the yeast,
Saccharomyces cerevisiae. In addition to its primary role, COGEME also aims to establish genome analysis for a
number of other important yeasts and fungi, including plant and human pathogens. Professor Steve Oliver of
the Faculty of Life Sciences coordinates COGEME and manages the Transcriptome Research Facility.

The Northwest Institute for Bio-Health Informatics (NIBHI) aims to facilitate the application of bio-health
informatics theory into practice and to ensure that bio-health informatics research is informed by the needs
of the biological and clinical research communities and those of the regional pharmaceutical and biotechnology
sector. The Institute forms a focal point for the coordination of bio-health informatics research, development
and training in the North West of England, facilitating collaborative activities within and between the academic,
industrial and health communities. NIBHI is a consortium of regional universities, led by The University of
Manchester, and is located within the Faculty of Life Sciences.

The National Centre for Text Mining, which will be housed in the Manchester Interdisciplinary Biocentre
(see page 11), is the UK’s contribution to the international research agenda concerning the retrieval and analysis
of textual data. The amount of scientific literature is growing so fast that there is an urgent need for novel,
computer-based tools to aid activities such as drug discovery and predictive toxicology, and studies of protein
interactions. The tools developed are applicable to academics in all subject areas, including social science and
arts and humanities, in analysing for example, ancient texts found by archaeologists. The Centre is run by an
international consortium that includes the Universities of Manchester, Liverpool and Salford, as well as the
University of California at Berkeley, the University of Geneva, the San Diego Supercomputing Center and the
University of Tokyo.

The Consortium for Post-Genome Science is a cross-institutional initiative designed to accelerate developments
in post-genome science and technology for the benefit of scientists, clinicians and companies – particularly those
operating in the North West of England. The Consortium was established in 2001. Its aims are to ensure that the
North West’s scientists realise their potential and make a significant contribution to post-genomic science, to
stimulate the development of a more vigorous, science-based regional economy, and to contribute to improved
public health in the region. The Consortium is harnessing programme-level funding opportunities in a more
managed, coherent and integrated manner than would be possible within a single institution, it is developing
more extensive and more productive partnerships with industry, and it is stimulating the creation of new
technology-based firms with trained, expert workforces. It is supported by the Universities of Manchester,
Liverpool, Salford and Lancaster, the Council for the Central Laboratory of the Research Councils (CCLRC),
and The Northwest Development Agency.

Our e-Science activity, including Bioinformatics, has been specifically praised by Professor Tony Hey, Director of
the e-Science Core Programme for Research Councils UK. The Victoria University of Manchester last year invested
over £3M in core infrastructure in this area. Manchester has a world-class reputation in middleware and grid
technology with particular relevance to bioinformatics, enhanced by a multidisciplinary approach and close
interaction with the local NHS Trusts.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Our Research Capability: Themes



Our Capability – Biomolecular Structure and Function
Technology Platform

• Biomolecule Synthesisacid synthesisFacilities
                        and Analysis                              • RNA Structure and Function of RNA by small molecules
                                                                    s Structure-selective recognition
  s Peptide and nucleic
   s DNA and protein sequencing                                     s RNA-protein interactions in the large ribosomal subunit
   s Bulk-scale fermentation facilities for protein expression      s Single molecule studies of the mechanism of ribosomal
                                                                      scanning
• Bioimagingmicroscopy
  s Electron
                                                                    s The molecular mechanisms of pre-mRNA splicing
                                                                    s Control of RNA synthesis
      • TEM, SEM, STEM, environmental SEM, X-ray microanalysis         • Transcriptional control of gene expression
   s Confocal microscopy                                               • Molecular mechanisms of action of nuclear hormone
                                                                         receptors
• Structural Biology Technology (NMR) analysis
  s Nuclear magnetic resonance
                                                                       • Molecular mechanisms of genetic switches
                                                                       • Molecular mechanisms of eukaryotic transcription factor
      • Solution phase                                                   function
      • Solid-state                                                    • Structure and function of haemopoietic transcription
   s X-ray crystallography                                               factors
   s Electron microscopy                                            s Control of RNA translation
   s Mass spectrometry                                                 • Regulation in response to stress
      • MALDI-TOF, electrospray                                        • mRNA decay
   s Circular dichroism                                                • RNA regulation of protein kinase function
   s Vibrational spectroscopy                                          • Structural analysis of the eukaryotic pre-initiation
      • Conventional and surface enhanced Raman optical                  complex assembly pathway
        activity spectroscopy                                       s Structure and function of novel mRNA cap binding proteins
      • Raman scattering
                                                                  • Biocatalysis
                                                                    s Structure-function analysis of ribonuclease MRP
Research Expertise
                                                                  • Biotechnology degradation
• Protein Structure
  s Protein folding
                                                                    s Lignocellulose
                                                                    s Bioprocessing of natural fibres
      • Secondary structure formation
      • Alpha-helical peptides and Alzheimer’s Disease            • Nuclear for the nuclear lamins
                                                                    s Roles
                                                                            Architecture
      • Natively unfolded proteins
      • Biogenesis of mitochondrial proteins                        s Chromosome structure and the replication programme
   s Membrane proteins                                              s Chromosome segregation
      • Solid-state NMR of membrane protein structure               s Molecular mechanisms of DNA replication and repair
      • Molecular interactions and protein dynamics                 s DNA damage repair
      • Biophysical approaches
      • Specific targets:                                         • Extracellular Matrix extracellular matrix domains, cellular
                                                                    s Crystallography of
          • Outer membrane protein from Neisseria meningitidis
          • Peripheral light-harvesting complex (LH2) from            receptors and adhesion molecules
            purple bacteria                                         s Structure-function and biotechnology of collagen
          • Signalling complexes in the neurones                    s Coiled coils in extracellular matrix proteins
          • Mitochondrial membrane proteins                         s Structure/function studies of microfibrils and vascular tissue
   s Structure and function of protein recognition modules          s Structure and function of connective tissues in health
   s Structure-function studies of cys-loop receptors                 and disease
   s Structures and dynamics of multiprotein complexes in heart     s Water structure in biological cells and tissues
     disease and cancer
                                                                                                                                                  11
                                                                                                                                Innovation in Action
                                                                                                      Strategic Collaborations with The University of
                                                                                                                Manchester’s Faculty of Life Sciences




Facilities of particular interest are:

The North of England Structural Biology Centre (NESBiC) was founded to promote research into the structure
of biological molecules using a range of biophysical techniques. NESBiC members are the Universities of
Manchester, Leeds and Sheffield. As a participating member of NESBiC, the Faculty of Life Sciences provides
bulk-scale fermentation facilities for protein expression and specialist expertise in various areas of structural
biology (e.g. electron microscopy, X-ray crystallography, NMR, Raman spectroscopy).

The Manchester Interdisciplinary Biocentre (MIB), which opens in July 2005, will be an extremely well-equipped
centre for the study of biomolecular structure and dynamics. A key feature will be that state-of-the-art facilities
and expertise for NMR, X-ray crystallography, electron microscopy, neutron scattering analysis, mass spectrometry
(including SIMS and FT-ICR) and circular dichroism will be housed together with equally impressive facilities and
expertise for EPR, microcalorimetry, infrared and Raman spectroscopy, stopped-flow fluorescence spectroscopy,
fluorescence correlation spectroscopy, high resolution imaging and single molecule technology. This will be a
unique combination of powerful biophysical technologies and know-how that can be used to explore biomolecular
structure and function in great detail, for example in the study of macromolecular folding/unfolding at secondary
and tertiary levels, intermolecular interaction/aggregation and interface behaviour.

The MIB will also house an EPSRC-funded Centre of Excellence in Biocatalysis, Biotransformations (Bioprocessing)
and Biomanufacture (CoEBio3). The Centre will comprise 60 to 80 researchers engaged in the use of enzymes for
the preparation of high-value speciality chemicals, including pharmaceuticals and their intermediates. The novel
science to be undertaken in Manchester will be spearheaded by Professors Nick Turner and Sabine Flitsch. The
inaugural Director of CoEBio3, Professor Stan Roberts, will ensure the smooth operation of key collaborations with
other academic institutes in the UK, as well as with industry. The overall objective of the Centre is rapidly to
expand the use of biocatalysis in synthetic organic chemistry.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Our Research Capability: Themes



Our Capability – Cell, Tissue and Organism
Technology Platform
                                                                          • Calcium channels
• Cell and Tissueplant cell
  s Animal and
                  Culture
                                                                              • Control of epithelial transport, cardiac muscle
                                                                                contraction and hormone secretion
     s Insect cells
                                                                              • Expression and function of Ca2+ in human embryonic
     s Microorganisms – bacteria, algae, fungi, protozoa
                                                                                stem cells
                                                                              • Control by proto-oncogenes
• GM Technologies and plants
  s Transgenic animals
                                                                              • Regulation of endoplasmic reticulum calcium stores
                                                                              • Molecular physiology of the extracellular Ca2+
     s Gene targeting
                                                                                sensing receptor
     s Expression profiling
                                                                              • Control of Ca2+ in enteroendocrine
     s All recombinant DNA technologies
                                                                       s Cell death
                                                                          • Apoptosis, intracellular organelles and disease
• Cellular Manipulation cell sorting
  s Fluorescence-activated
                                                                          • Regulation of stress-induced cell death
                                                                          • Regulation of apoptosis by membrane alteration
     s Flow cytometry
                                                                       s Membranes and organelles
                                                                          • Organelle and membrane biosynthesis
• Monoclonal Antibody Production And Immunoassay
  Development
                                                                          • Protein targeting and translocation at the endoplasmic
                                                                            reticulum
                                                                          • Vesicular transport and membrane fusion
• Bioimagingmicroscopy
  s Confocal
                                                                          • Structure and function of the Golgi apparatus
                                                                       s Cell adhesion
     s Electron microscopy
                                                                          • Adhesion-dependent signalling pathways
        • TEM, SEM, STEM, environmental SEM, X-ray microanalysis
                                                                          • Adhesion dependent survival, differentiation and
                                                                            development of epithelial cells
• Structural Biology Technology
  s See page 10
                                                                          • Molecular basis of cell adhesion and its role in
                                                                            human disease
                                                                          • Molecular mechanisms underlying synapse formation
                                                                       s Microtubule motors
Research Expertise                                                     s The molecular basis of circadian rhythmicity

• Stem Cells stem cells
  s Embryonic                                                        • IonStructure/function of ion channels in neurons, endocrine
                                                                           Channels and Solute Transport
                                                                       s
        • Early development and implantation of the
                                                                         cells, epithelial cells and muscle cells
          mammalian embryo
                                                                       s Pharmacology of ion channels
        • Stem cells and 5T4 oncofetal antigen
                                                                       s Anion channels in the choroid plexus and islet
        • Human embryonic stem cells and diabetes mellitus
                                                                         endocrine cells
     s Adult stem cells
                                                                       s Potassium channel pharmacology and gap junctional
        • Vascular tissue engineering using mesenchymal stem cells
                                                                         pathways involved in endothelium-muscle cross talk
        • Tissue repair
                                                                       s Structural determinants of ligand gated ion channel
        • Nerve regeneration
                                                                         receptors for ATP and acetylcholine
        • Breast epithelial stem cells
                                                                       s K+ channels in insulin-secreting cells
        • Haematopoietic stem cells
                                                                       s Voltage-gated Ca2+ channels in stem cells and neurons
        • Pancreatic stem cell biology
                                                                       s Hypoxia and K+ channel regulation
                                                                       s Ion channel trafficking
• Cell Biology
  s Cell signalling
                                                                       s Control of ion channels by ATP-binding cassette proteins
                                                                       s Heterogeneity and function of iron transporters
        • Interactions between signalling pathways during
                                                                       s Iron and other ion transport in the kidney
          mammalian development
                                                                       s Fluid and electrolyte transport across the choroid plexus
        • Structural biology of signalling proteins
                                                                         and placenta
        • Protein phosphatases and signalling proteins
                                                                       s Bicarbonate and water transport in the pancreatic duct
        • Functional characterisation of Raf-kinases
                                                                       s Fatty acid signalling and transport across the epithelia of
        • Inositol lipid function and regulation
                                                                         the GI tract
        • IGF signalling and clinical endocrinology
                                                                                                                                               13
                                                                                                                             Innovation in Action
                                                                                                   Strategic Collaborations with The University of
                                                                                                             Manchester’s Faculty of Life Sciences




• Extracellular Matrix
  s Microfibrillar components
                                                                       • Plant Biology and genetics of plastids
                                                                         s Biochemistry
  s Relationship between extracellular matrices, cell-matrix                • Chloroplast transformation technologies and the
    interactions and disease                                                  expression of foreign proteins in plastids
  s Matrix assembly and structure                                           • Starch metabolism
  s Laminin function                                                        • New proteomics approaches
  s The extracellular matrix of the eye                                         • Chloroplast diversity
  s Proteoglycan functions in the extracellular matrix                          • Adaptation of chloroplasts to environmental stress
  s Pathobiology of the epithelial mucus barrier                                • Regulation of photosynthetic electron transport
                                                                         s Cell and developmental biology
• Tissue Development and Remodelling growth in
  s Genetic control of bone and cartilage
                                                                            • Genes involved in secondary cell wall formation,
                                                                              patterning of the vascular tissue, programmed cell death,
    development and in disease                                                transport of metals and DNA repair
  s Molecular regulation of skeletal development and new                    • Responses to environmental stresses such as UV irradiation
    blood vessel formation                                                  • Mechanical properties of plants and development of
  s Wound healing and tissue repair                                           novel plant fibres
     • Cellular and molecular mechanisms underlying human                   • Biochemistry of nitrogen mobilisation during cereal seed
       wound healing and scarring                                             germination and grain filling
     • Molecular cell biology of palate development                      s Plant adaptation, acclimation and evolution
                                                                            • Distribution and taxonomy of ferns
• Adaptive Organismal Biologymolluscs, crustaceans, fish
  s Various models (microbes,
                                                                            • Development of freshwater algal blooms
                                                                            • Adaptations of tree architecture to environmental
    and mammals)                                                              pressures
     • Circadian clocks                                                     • Effect of leaf crystals on the behavior of herbivores
     • Neuronal plasticity
     • Body fluid homeostasis
     • Hormonal regulation
                                                                       • Population and Evolutionary Biology
                                                                         s Genetics and development of morphological traits
  s Adaptive physiological responses to environmental                    s Evolution of development, sex differences, mating
    challenges                                                             behaviour, and parental care
     • temperature, light, nutrition and toxicants                       s Evolutionary genetics and sexual dimorphism in insects
     • whole organism, tissue and gene expression levels                 s Behaviour genetics, olfaction and chemical communication
                                                                         s Adhesion and biofilm formation in microbial communities
                                                                         s Microbial ecology




Facilities of particular interest are:

The Wellcome Trust Centre for Cell-Matrix Research contains            The UK Centre for Tissue Engineering is an interdisciplinary
Europe’s largest research grouping (approximately 150 individuals)     research collaboration supported by £10M funding from BBSRC,
dedicated to extracellular matrix biology and associated cellular      EPSRC and MRC and led by Professor Tim Hardingham of the
interactions. The Centre has key expertise in cell adhesion,           Faculty of Life Sciences and Professor David Williams of the
extracellular matrix structure and function and matrix-induced         University of Liverpool. The Centre focuses on basic bioscientific
cell signalling including prevention of cell death. The aims include   research underpinning the development of clinical applications in
definition of the molecular principles that determine how cells        tissue engineering and regenerative medicine. Three major clinical
respond to their environment and determination of the role of          programmes – Skin/Wound Healing, Cartilage/Disc Repair and
the extracellular matrix in the function of natural and engineered     Vascular Tissue Engineering – are underpinned by basic research
tissue.                                                                into areas such as haemodynamics (how blood behaves),
                                                                       biocompatability (which determines whether transplant organs
                                                                       will be rejected), inflammation and gene transfer.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Our Research Capability: Themes



Our Capability – Molecular Basis to Disease
Technology Platform

• Cell Culturecell culture                                           • Bacterial Diseases
                                                                       s Structure and function of proteins involved in
  s Bacterial
     s Malaria parasite                                                  bacterial disease
     s Animal cell models                                              s Disease processes and chemotherapeutics in
     s Virus culture                                                     pathogenic bacteria
     s Appropriate containment facilities for growth of pathogens      s Molecular mechanisms of plasmid segregation
                                                                       s Toxin-antitoxin systems
• GM Technologies
  s Transgenic animals
                                                                       s Pathophysiology of fever

     s Gene targeting                                                • Viral Diseases
                                                                       s Hepatitis C
     s Expression profiling
     s All recombinant DNA technologies                                s Virus assembly
                                                                       s Antiviral protein kinases
• Monoclonal Antibody Production And Immunoassay
  Development                                                        • Parasitic Diseases
                                                                       s Malaria
• Genomics and Bioinformatics Technology
  s See page 8
                                                                          • Parasite resistance to antifolate drugs
                                                                          • Folate biosynthesis and salvage
                                                                          • Development of proteomics tools
• Structural Biology Technology
  s See page 10
                                                                       s Toxoplasma gondii

                                                                     • Immunity andof the immune response
                                                                       s Regulation
                                                                                    Infection

Research Expertise                                                        • Regulation of parasitic infection by T lymphocytes
                                                                            under cytokine control
• Cancer and dynamics of multiprotein complexes in cancer
  s Structures
                                                                          • Mucosal immune responses in the gut
                                                                          • Induction of immune responses by antigen-
     s Causal relationship between oxidative stress and cancer              presenting cells
     s Role of cell adhesion molecules                                    • Regulation of autoimmunity
     s Breast cancer                                                   s T cell memory to vaccines
     s Isolation and characterisation of normal and leukaemic          s Genetic control of immune responses
       primitive haematopoietic stem cells                             s Pathogen-host interactions
                                                                          • Biology of the pathogen
• Cardiovascular Diseases of multiprotein complexes in
  s Structures and dynamics
                                                                          • Host response to infection
                                                                       s Expression of virulence factors
       heart disease                                                      • Role of bacterial cell surface molecules in mediating
     s Ion channels in heart disease                                        interactions with host cells
     s Reactive oxygen species in atherosclerosis and hypertension     s Host response to infectious challenge
                                                                          • Mechanisms of cellular immunity
• Neurodegenerative Diseases oxidative stress and
  s Causal relationship between
                                                                          • Control of resistance and susceptibility at the levels of
                                                                            pattern recognition, antigen presenting cell and cytokine
       neurodegenerative disorders                                          mediated regulation of T cell responses
     s Alpha-helical peptides and Alzheimer’s disease                  s Immunity to parasitic infection
     s Inhibition of amyloid formation                                 s Influence of host genetics on immune responsiveness

• Diseases ofdiseases of bone and cartilage
  s Genetic
              the Skeletal System

     s Structure and function of connective tissues in health
       and disease
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                                                                                                      Strategic Collaborations with The University of
                                                                                                                Manchester’s Faculty of Life Sciences




Of particular interest:

Senexis Ltd is a Faculty of Life Sciences spin-out company dedicated to the discovery, optimisation and early
clinical development of novel proprietary technologies and pharmaceutical drug candidates for the early diagnosis
and effective treatment of major ageing-related diseases associated with amyloidosis and protein/peptide
aggregation. The vision is to revolutionise the diagnosis and treatment of major amyloid-related diseases such
as diabetes, Alzheimer’s and Parkinson’s diseases by developing beta-sheet breaker compounds as potent drug
candidates to inhibit and reverse the common pathogenic mechanism of amyloidosis now associated with a
number of incurable degenerative diseases. The core technology comprises a novel class of short, synthetic
N-methylated peptide derivatives called ‘meptides’, which can be adapted to inhibit and reverse the aggregation
and toxicity of any amyloidogenic protein or peptide associated with disease, and which have a number
of unique properties that appear to overcome many of the bioavailability issues typically faced by natural
peptide-based drug candidates. Senexis received the 2003 Northwest Biotechnology Start-up of the Year award.

Cancer research in Manchester takes place not only in the Faculty of Life Sciences, but also in the Division of
Cancer Studies of the Faculty of Medical and Human Sciences, at the Christie Hospital and Paterson Institute for
Cancer Research (PICR), and in various local hospitals. There are many links between these bodies and the overall
cancer research programme in Manchester is collaborative and coordinated.

Christie Hospital has over 10,000 new cancer patients per year and provides most of the specialist radiotherapy
and chemotherapy for the local population of 3.5 million people – the largest single catchment area in the UK –
yielding a wealth of material for clinical and translational research. PICR, which is funded by Cancer Research UK,
provides laboratory space mainly for basic research. Many of the senior staff of both these bodies are employed
by or have honorary appointments at The University of Manchester.

The basic research in PICR includes control of cell division, regulation of DNA replication, carcinogenesis,
immunology, glycobiology, structural biology, molecular genetics, apoptosis, gene therapy and functional
genomics. One of the aims of the Faculty of Medical and Human Sciences is to translate this basic research into
therapies for cancer and to understand the pathophysiology of the disease. Examples of how this has been
achieved include collaborations which have led to the discovery and early clinical trials of haemopoietic growth
factors, the use of anti-angiogenic factors to inhibit tumour growth, and the development of anti-cancer vaccines
that are now coming to the end of clinical trials. Major areas covered by University researchers include glycobiology,
growth factors and angiogenesis, immunology and cancer vaccines, radiotherapy research and radiobiology, clinical
research and drug therapy trials, with the diseases under study including breast cancer (with the University
Hospital of South Manchester), lung cancer (also with South Manchester), leukaemia, lymphoma, prostate cancer
(with Hope Hospital), childhood cancers (with Central Manchester and Manchester Children’s Trust), and viral
aetiology of cancer of the cervix (also with CMMCT). The Faculty of Medical and Human Sciences is also involved
in work on home nursing and complementary therapies, cancer pharmacology and mouse models.

To facilitate this research base, a number of facilities have been developed in the University including a dedicated
innovative therapy unit, world-class PET imaging, dedicated radiotherapy research facilities and funding for new
laboratories to support translational research.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Our Research Capability: Themes



Our Capability – Neuroscience and Vision
Technology Platform

• Imaging Technology and whole animal/human imaging
  s Subcellular, cellular                                              s Integration within neuronal-glial networks
   s Magnetic resonance techniques                                     s Nature of afferent signalling
   s Combined fMRI and EEG                                             s Pathological modification of neural signalling cascades
   s Multimodality neuroimaging                                          under neurodegenerative conditions
   s Targeted probe molecules labelled with a chromophore or           s Molecular imaging to reveal endogenous molecules and
     MRI positive reporter                                               specific cell populations in the brain
                                                                       s Effects of different anaesthetics on ltp in mammalian
• Recording of Brain Activity
  s Intra - and extra-cellular
                                                                         hippocampus
                                                                       s Relation between ltp, sleep and memory formation/
   s In vivo electrophysiological recordings                             consolidation
                                                                       s Influence of cues and role of hippocampus in early stages
• Cornea Examination
  s Ocular dioptrics
                                                                         of motor learning

   s Thermographic methods                                           • Neuronal Degenerationneuronal death
                                                                       s Signals which cause
                                                                                             and Regeneration
   s Microscopy
                                                                       s Molecular mechanisms of cell death, survival and repair
                                                                       s Cell death and survival drug development
Research Expertise                                                     s Molecules, receptors and mediators of injury/repair, and
                                                                         inhibitory factors which influence regeneration
• Neurophysiological Basis ofof neuronal function
  s Temporal characteristics
                              Neuroimaging Signals                     s Clinical programmes
                                                                          • Clinical trials of new interventions
   s Physical and biochemical processes underlying                        • Application of MR imaging techniques
     imaging methods                                                      • Investigation of cognitive recovery after brain injury
   s Coupling between haemodynamic response probed by                  s Linking neurological dysfunction and fundamental
     MRI and neuronal activity                                           measures of neuronal behaviour
   s Mathematical and statistical modelling of imaging signals         s Experimental models of disease
                                                                          • Diabetic neuropathy
• Neural Coding of Sensory, Motor and Perceptual Processes
  s Network coding of sensorimotor transformations in the
                                                                          • Movement disorders
                                                                          • Ischaemic brain injury
     basal ganglia with applications to motor learning and                • Ageing neuroinflammation
     sensorimotor integration
   s Statistics of the natural visual world and its representation   • Vision
                                                                       s Optometric, psychophysical and fundamental neuronal
     by neural coding
   s Progressive transformation of colour information through            research approaches
     ascending levels of neural architecture                           s Quality of retinal image and impact on performance
   s Temporal development and spatial localisation of motor               • Ocular dioptrics, thermographic and microscopic
     learning mechanisms                                                    examination of the cornea
   s Neuronal substrates and mechanisms of evolution of visual            • Assessment of the impact of low vision and diabetes
     motion sensitivity                                                s Neuronal mechanisms studied at subcellular, neural and
   s Validity of physiological models of neuroimaging signals            systems analysis levels
     underlying the haemodynamic response                                 • Neural basis for colour perception
   s Role of the cerebrospinal fluid in development, pathology            • Normal and abnormal oculomotor function
     and neurodegenerative conditions                                     • Links between visual perception and action
                                                                          • Impact of disease
• Signalling in the NervousofSystem signalling in neural cells
  s Molecular physiology intracellular                                 s Visual psychophysics
   s Identification of main determinants of synaptic plasticity           • Colour and shape processing in normal and impaired
                                                                            vision
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                                                                                                     Strategic Collaborations with The University of
                                                                                                               Manchester’s Faculty of Life Sciences




Facilities of particular interest are:

The newly formed Institute of Neuroscience Research brings together neurobiologists from 5* groupings in the
two former institutions with clinicians, engineers, computer scientists and bioimagers. The goal is to address
key questions in basic and clinical neuroscience. Major research themes will be: the neurophysiological basis of
neuroimaging signals, with strong links to recent major investments in PET and MR imaging in Manchester;
neural coding and integrative responses to the environment which includes particular strengths in coding of
sensory signals; and neuronal degeneration and regeneration encompassing several major clinical programmes.
The Institute has received external support from OST (£5M), has already benefitted from several senior academic
appointments and will be located in a new £40M building that is currently being designed.

Eurolens Research – the European Centre for Contact Lens Research – was established in 1990 to act as a research
and consultancy unit for the global contact lens industry. Since its formation, the unit has undertaken clinical
trials and basic clinical research for 15 companies with interests in this area. The unit offers a complete clinical
trial service for new contact lenses or contact lens related product including protocol development, ethical
review, full clinical evaluation, data analysis and report writing. Unit personnel have significant experience
coordinating multicentre activities and have worked with about 30 optometrists around Europe. In addition
to responding to the specific needs of the individual companies, Eurolens Research conducts generic work to
support practitioners and the industry as a whole, and also has a strong history in the area of postgraduate
research in the cornea/contact lens field.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Commercialisation of Life Sciences Research




                                The University of Manchester Intellectual Property Ltd (UMIP) is the University’s
                                authorised agent for intellectual property management and commercialisation.
                                It builds on the successful experiences and track records of Manchester Innovation Ltd
                                and UMIST VENTURES Ltd. Together these organisations have set up about 100 licences
                                and 80 spin-off companies, some of which have been listed on the UK stock markets.
                                In addition, they have won prestigious awards for technology transfer in a range of
                                technical and scientific areas. Through their research management and technology
                                transfer responsibilities, they have developed an international network and are highly
                                familiar with complex collaborative agreements and consortia arrangements and have
                                a very good knowledge of dealing with intellectual property issues arising in contracts
                                with industrial partners.


                            The Faculty of Life Sciences has an excellent record in the establishment of successful spin-off companies,
                            three examples of which are described below:

                            Renovo (www.renovo.com)
                            Based in the Manchester Incubator, Renovo has raised Series B financing of US$37M from Atlas Venture,
                            JP Morgan, HealthCap, Care Capital, Temasek and BioVeda. Renovo is a biopharmaceutical company developing
                            novel products to prevent scarring or accelerate healing following trauma, injury or surgery to any body site.
                            The initial focus is on the skin, which alone represents a multi-million dollar market of unmet medical need.
                            Renovo will develop pharmaceutical products at least up to Phase II clinical development and is also open to
                            research collaborations at earlier discovery and development stages.

                            A high performance culture of innovation and scientific and clinical excellence has allowed Renovo to pursue
                            pioneering programmes of drug discovery and development in the rapidly evolving fields of scar prevention and
                            wound healing. Renovo has its own fully staffed Clinical Trials Unit and a productive R&D programme focussed
                            on wound and scar biology, pharmacology, genomics and proteomics.

                            Renovo intends to launch its product range globally and anticipates partners for several of these products,
                            particularly those already identified as having blockbuster potential.
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                                                                                                     Strategic Collaborations with The University of
                                                                                                               Manchester’s Faculty of Life Sciences




Motac Neuroscience (www.motac.com)
Motac was founded in 1999 as a spin-off company, built upon 25 years of experience in the field of movement
disorders developed in the laboratory of Professor Alan Crossman.

Motac Neuroscience provides highly specialised laboratory services for pharmaceutical and biotech companies to
support the discovery and development of therapeutics for neurological and psychiatric disorders. Motac personnel
have particular expertise in neurodegenerative conditions, including Parkinson’s disease and other movement
disorders. Motac also has an intellectual property portfolio covering therapeutic targets for movement disorders,
which it is developing through strategic alliances and partnerships.

Motac is headquartered at Manchester Science Park at the heart of Manchester’s academic, bioscience and clinical
communities.




Gentronix (www.gentronix.co.uk)
Gentronix was established in July 1999 to commercialise technology developed jointly in the Departments of
Biomolecular Sciences and Instrumentation & Analytical Science at UMIST. Gentronix is an innovative biotechnology
company helping to accelerate the pace of drug development in the pharmaceutical industry. Gentronix is
delivering a range of productivity-enhancing tools for scientists in the drug discovery field, designed to ease or
remove current bottlenecks in pre-clinical research and development.

Gentronix’s first product release, GreenScreen®, successfully combines our expertise in molecular biology and
analytical science to address the ADMET bottleneck in lead candidate selection, focusing specifically on genotoxicity
screening. Gentronix has entered into an exclusive marketing deal with the British Technology Group through
which BTG is co-promoting and negotiating sales of GreenScreen products as a component of their drug
development portfolio, Mettox®.

Gentronix was awarded the Innovative Enterprise Award 2003 by Excellence North West in October 2003.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Recruiting Talent




                                Recruiting the right graduate talent is critical for business success in today’s knowledge
                                economy. UMIST and the Victoria University of Manchester have always been highly
                                targeted by graduate recruiters. The new University builds on this rich history and
                                with over 30,000 high-calibre students (1,500 in Life Sciences), studying a wider range
                                of disciplines than at any other UK university, we are able to make a unique graduate
                                recruitment offer to industrial partners.


                            Our Business, Careers & Community Division (BCCD) incorporates the University’s Careers Service which is
                            consistently voted by blue-chip recruiters as the best HE Careers Service in the UK*. We have extensive experience
                            of working creatively with a wide range of leading global recruiters to help deliver their recruitment strategies.
                            We have worked closely with over 13,500 companies from diverse sectors including AstraZeneca,
                            GlaxoSmithKline, Pfizer, Northern Foods, Mars, Cadburys, Unilever, Geest, JP Morgan, BP and the NHS.

                            The breadth of our portfolio, coupled with our expertise and experience, guarantees that partners are provided
                            with a tailored package of recruitment solutions, accompanied by first-class support from a dedicated team of
                            recruitment professionals.

                            Our current offer to graduate recruiters includes the following elements:

                            Recruitment Fairs
                            We have an established reputation for running one of the largest programmes of graduate recruitment fairs in
                            the UK including:
                            • The Science, Engineering & Technology Fair
                            • The Finance, Business & Management Consultancy Fair
                            • The Summer Graduate Recruitment Fair

                            Our fairs are held at a range of prestigious and accessible venues across Manchester and are attended by over
                            350 exhibitors. With extensive promotion and sponsorship from national media partners such as The Guardian
                            and The Independent, more than 22,000 students and graduates from across the UK attend the fairs each year.
                            The fairs are highly rated by corporate clients. Our Summer Graduate Recruitment Fair has been voted the most
                            effective fair in the country by graduate recruiters*.

                            “The leading Careers Service in the UK and the one for other universities to aspire to.”
                            Carl Gilliard, Chief Executive, Association of Graduate Recruiters

                            Curriculum-Based Activities and Workshops
                            Our programme of seminars and workshops which have employer input include:
                            • Career Management Skills Modules – These modules form part of the students’ degree programme and give
                              them the opportunity to work with employers to develop a range of employability skills such as commercial
                              awareness and business negotiation. They are an ideal way for companies to build relationships with academic
                              schools and to target specific groups of students. We deliver 27 modules across all Faculties of the University.
                            • Insight Courses – These one-day courses give recruiters the opportunity to use case-study material, based on their
                              own organisation, to give students an insight into business realities. Previous courses have included Women in
                              IT Consulting and Working for A Global Organisation. We are always happy to work with new partners to
                              develop courses best suited to specific recruitment needs.
                            • Skills Development for Postgraduates and International Students – Recruiters wishing to target postgraduate
                              and PhD talent, or students from particular countries, can get involved in skills workshops designed for these
                              students.

                            *AGR/Barkers National Graduate Media Audit
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                                                                                                                             Innovation in Action
                                                                                                   Strategic Collaborations with The University of
                                                                                                             Manchester’s Faculty of Life Sciences




Mentoring
Our mentoring programmes support recruitment activity and are also a useful staff development tool.
We have a range of programmes:
• Manchester Gold – a flagship programme involving 150 students and organisations and a strand targeted
  at MBA students.
• Interface (for Black and Asian students) – a programme for companies wishing to target black and Asian students.
• Interact (for disabled students) – a programme for companies wishing to target students with a disability.

Organisations involved in our mentoring programmes include AstraZeneca, Johnson & Johnson Medical, Goldman
Sachs International, BT, Granada TV and HSBC. All offer e-mentoring options allowing employees based at any
global location to link up with our students.

“Through meetings with my Manchester Gold mentee, I have gained a useful insight into the employment
challenges facing students in the current commercial climate. To help someone navigate those is a very
rewarding process.”
Rowan Dodd, Manager, Accenture

The Web & Graduate Profiles
The main Careers Service website, www.manchester.ac.uk, has over 3,000 pages and is well used, not only by our
own students, but by a significant number of visitors from across the world. We have a dedicated team of web
developers and designers, who work with our marketing and events staff to ensure we make maximum use of
ICT to support the ambitions of our graduate recruiters.

“The most technologically advanced Careers Service in the UK.”
Linsey Perry, National Recruitment Manager, Network Rail

Vacancy Advertising
Each year we publicise tens of thousands of jobs and placements, across a wide range of printed and digital
media. All vacancy advertising is free of charge.

Diversity & Work Experience
Diversity Initiatives – we offer a well respected portfolio of products to help employers address diversity.
These include an Ethnic Diversity Fair, a national recruitment website for ethnic minority students,
blackandasiangrad.co.uk, the Interface and Interact mentoring programmes and events targeted at female
students.
Placements & Work Experience – more and more employers are now using internships and work placements
to source their new recruits. Student WorkPlace is our specialist vacancy service for undergraduate placements,
internships and work experience opportunities.

Consultancy & Advice
We are able to offer partner organisations an Account Manager and access to the resources of a team of 80
recruitment and business professionals within the Business, Careers & Community Division, and also to recruitment
and business colleagues based in the Faculty of Life Sciences. This provides unrivalled graduate recruitment
consultancy and excellent access to large numbers of bright and highly employable students and graduates.
No other university in the UK is better equipped to meet organisations’ graduate recruitment needs.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Developing Talent




                                It is now widely recognised that education does not stop after leaving college or
                                university and that it is a business imperative for employees to learn new skills
                                or update the knowledge they already have.

                                The University of Manchester is one of the largest providers of continuing education
                                in UK higher education. We help thousands of people every year who return to learn,
                                full-time or part-time, on long or short courses, on campus or at a distance.



                            The University of Manchester offers training and continuing education courses to business and industry.
                            Continuing professional development is via stand-alone short courses, postgraduate study and distance learning,
                            designed to enable business and industry to maintain a knowledgeable and highly skilled workforce.

                            Short courses and seminars offer continuing education provision with a vocational focus. These are offered for a
                            range of professions and occupations and are co-ordinated by individual faculties, centres and units.

                            Additionally the University runs company specific courses for medium and large organisations, and open access
                            courses for participants from organisations of all sizes. The strong links that have been forged between the
                            combined University and the world of industry and commerce help us to identify partnership needs and to feed
                            back the fruits of our research.

                            The University also runs distance learning courses suitable for business and industry. Distance learning study
                            includes postgraduate programmes and short courses which may include periods of study at the University or
                            a study centre.

                            What is on offer in Life Sciences
                            The Faculty of Life Sciences is building on its reputation as a leading provider of traditional graduate education
                            by developing new types of training and continuing education tailored for the bioscience industry.

                            Masters in Research (MRes)
                            The MRes is now established as an innovative new way for a graduate to start out on a research career. The
                            one-year, full-time degree enables each student to gain research experience and professional skills, sometimes
                            in a different area to their first degree, before deciding on a future career in industry or academic research.
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                                                                                                                               Innovation in Action
                                                                                                     Strategic Collaborations with The University of
                                                                                                               Manchester’s Faculty of Life Sciences




Our new MRes in Integrative Biology has been awarded three BBSRC studentships and has additional financial
support from GlaxoSmithKline to cover the costs of consumables and future course development. We are
establishing links with other companies in order to develop the MRes so that it provides training that reflects
the specific needs of our industrial partners.

e-Learning and Distance Learning
e-learning enables us to extend the reach of our established programmes to those unable to attend a
conventionally taught course. Modules are offered through web-based distance learning and may be studied
individually, or as elements of a full MSc programme.

The courses are offered within a Virtual Learning Environment (VLE). The tools provided within the VLE allow
the student to navigate and search through course notes, protocols, practicals and references to useful texts and
URLs. The course notes, as web pages, provide the necessary background to the focus of each course, which is
problem-based learning. Problem solving through team working is actively encouraged. Students interact with
members of the course team and with other learners through email, a course bulletin board and ‘chat rooms’ for
on-line tutorials.

The modules currently available are from the established MSc programmes in Bioinformatics and Immunology &
Immunogenetics. The qualifications available are the Postgraduate Certificate, the Postgraduate Diploma and the MSc.

The Bioinformatics programme (run jointly with the University of Leeds and in collaboration with the University
of California, San Diego) covers topics such as microarray data analysis, the bioinformatics of protein structure,
the science of proteomics, molecular modelling and structure-based drug design.

Options in Immunology and Immunogenetics include clinical immunology and transplantation, immune
physiology and autoimmunity.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Working with Communities: Sharing Values




                                We believe that a successful organisation should be measured by its contribution to
                                society. The University of Manchester is committed to making a significant contribution
                                to the social, cultural and economic development of our community, and more broadly
                                to the development of a secure, humane, prosperous and sustainable future for all.




                            In the Faculty of Life Sciences we are committed to engaging and supporting wider community interaction and
                            believe that equipping our scientists with the skills to communicate effectively with both young people and the
                            wider population is a key requirement of science in the 21st century.

                            Working with Young People
                            We have an established programme of activities engaging young people in the Life Sciences. The Firs Experimental
                            Botanical Grounds contain study facilities and plant houses which enable the study of plant species from tropical
                            rainforests to alpine regions. The Firs has a dedicated Outreach Centre which aims to introduce both children and
                            adults to the world of plants and raise awareness of their importance, and our dependency upon them for many
                            things. The Centre enables schools to visit the grounds, make use of the collections and teaching facilities free of
                            charge. Each year a number of our undergraduate students also work alongside teachers as part of their final
                            year projects to develop teaching materials and education packs for both primary and secondary school use. The
                            Firs also hosts an annual Big Draw event where local school children visit for a day to study and draw some of the
                            plants and explore the links between art and science.

                            Our scientists deliver between 60 and 70 sessions a year in schools covering a wide variety of areas related to
                            life sciences including masterclasses for young people considering studying a life science. Taster sessions and
                            showcases on campus are delivered each year to groups of around 50 young people in areas such as neuroscience
                            and the origins of agriculture. Schools regularly visit the campus to use our extensive lab facilities and our schools
                            liaison team are always ready to assist individual schools access expertise and facilities across the Faculty.
                            We also collaborate with external partners to engage young people in science through activities such as a joint
                            poster competition for year 10 pupils with AstraZeneca. During this event, young people spent a day on campus
                            and then designed and produced posters based on the experiments undertaken and their experiences of the day.

                            Communicating Science
                            Science and society, and communicating science as widely as possible, are key activities for the Faculty. During
                            their second year, our undergraduates have the option of taking an accredited degree module in science, the
                            media and the public. This ensures that from the very beginning of their scientific careers our graduates are
                            made aware of the important relationship between science and the public. Our 400 postgraduate students are
                            ideal advocates for bringing science to young people in our local community and embedding our researchers
                            within the wider community. We are developing science communication training sessions designed specifically for
                            life science researchers to equip them with the skills necessary to engage the public in science discussion and debate.
                                                                                                                                               25
                                                                                                                              Innovation in Action
                                                                                                    Strategic Collaborations with The University of
                                                                                                              Manchester’s Faculty of Life Sciences




Our staff are important communicators of science and many of them give public lectures and talks, both locally
and nationally, covering subjects as diverse as neuroscience, GM crops and ancient DNA. We support wider
University public engagement with science and regularly contribute at Café Scientifique Manchester with previous
discussions on wound healing, diseases of the brain and reintroducing wolves to Britain, all particularly well
received by the diverse audiences attracted to these events. Our researchers and postgraduates regularly assist
with demonstrations at the Manchester Museum in the Science for Life Gallery on topics such as “DNA Your
Onions” amongst others. We are supporting science communication outside of the University and are an active
member of the North West Science Alliance (NWSA), which is a unique network of science communicators from
across the North West of England. We support the NWSA both as a member of its steering group and as a participant
in their events. Our staff and their scientific developments feature in the new Manchester Science Gallery at the
Manchester Museum of Science and Industry along with many other University of Manchester staff from both the
past and present.

The Faculty is home to the Centre for the History of Science, Technology and Medicine (CHSTM) which is actively
involved in supporting a wide variety of public engagement activities. CHSTM’s main aim is to stimulate interest
in and increase understanding of the development of science, technology and medicine. They are developing
a range of resources and events for diverse audiences, including school children aged 11-18, professionals and
students in the biomedical sciences, patients, and the interested public at large. For example, they are developing
a series of lesson plans for teachers delivering the new A/S level “Science for Public Understanding”.

Future plans for developing science communication activities include establishing additional Teaching Fellows
to deliver more public lectures and schools presentations and running masterclasses for science teachers and lab
technicians so that they can experience the latest biological techniques and transfer these into the classroom
and school laboratory.
26
Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences
                                                                                                                                              27
                                                                                                                             Innovation in Action
                                                                                                   Strategic Collaborations with The University of
                                                                                                             Manchester’s Faculty of Life Sciences




Appendix A

About The University of Manchester



   The University of Manchester was launched in October 2004 by joining the forces
   and combining the strengths of two leading institutions: The Victoria University of
   Manchester and UMIST. It will build upon their existing reputations for academic
   excellence and for the high employability of their students and graduates.



The new university:
• Is attracting more applicants than anyHigher UK University
                                          other
• Is a powerful new forceinvested in the campus to improve already excellent
                           in the British       Education sector
• Has over £300M being facilities
  teaching and research
• Teaches the widest range of subjects in the UK
Prizes and Achievements:
• Over 23 NobelQueen’sto its credit Education three times
                 Prizes
• Winners of the only Department for Trade & Industry Award for Technology Transfer
  Awarded the            Prize for Higher
• Winner of the Prince of Wales Award for Innovation
• The first stored-program computer was created at The Victoria University of Manchester in 1948
•

  Current Student Numbers (combined)
  Undergraduates: 23,927
  Postgraduates: 8,607



Core/Single Discipline Courses Include:
Accountancy & Finance, Architecture, Architectural Science, Art History & Archaeology,
Applied Social Sciences, Biological Sciences, Business Studies, Chemistry, Classics, Computer
Science, Construction Management, Dentistry, Drama, Earth Sciences, Economics, Education,
Engineering (Aerospace, Building Services, Civil & Structural, Chemical, Communication &
Control, Electrical & Electronic, Manufacturing, Mechanical), English, Geography,
Government, History, Languages & Linguistics, Law, Management, Management & Leisure,
Materials Science, Maths, Medicine, Middle Eastern Studies, Music, Nursing & Midwifery,
Neuroscience, Optometry, Pharmacy, Philosophy, Physics & Astronomy, Planning &
Landscape, Psychology, Religion & Theology, Social Anthropology, Social Policy, Sociology,
Textiles (Design, Management, Retailing, Science, Technology) and Zoology.
28
Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Appendix B

Business, Careers & Community Division



                            Business, Careers & Community Division
                            One of the key ambitions of the merger between The Victoria University of Manchester and UMIST was to
                            introduce a radical new approach to our engagement with corporates and to significantly grow our research
                            collaborations with business and external partners.

                            Part of this vision involved setting up new a new structure which would provide a single point of access to the
                            rich and complex offer of the new University. This has been achieved through the establishment of a Business,
                            Careers & Community Division (BCCD).

                            The BCCD comprises a number of professional teams:
                            • Business Development Unit – forging strategic relationships with large external organisations
                            • Employability Team – developing the employability skills of our students and graduates
                            • Community Team – supporting social inclusion and educational opportunity
                            • Regional Development Unit– promoting the region’s economic growth.
                            These are underpinned by a range of operational resource teams including: marketing & events; systems & web
                            development; research & intelligence.

                            By pulling together staff working the business development, employability and community agendas, the BCCD is
                            able to promote a seamless solution to corporate need including:
                            • Research and consultancy links to some of the UK’s leading academics
                            • Access to over 30,000 high calibre students
                            • Access to a wide range of professional development courses
                            • Opportunities for collaboration with a diverse array of community activities.

                            Each faculty is also setting up complementary structures to ensure that the University has the capacity to
                            develop effective and responsive collaborations with business and external partners. These include dedicated
                            teams to support and coordinate research contracts and spin-out activity.

                            The new structures in both the centre and in the faculties will work in tandem to ensure that The University of
                            Manchester is able to initiate and grow large-scale strategic relationships with the most demanding of corporate
                            and external partners.
                                                                                                                                                  53
                                                                                                                                                  29
                                                                                                                                  Innovation in Action
                                                                                                        Strategic Collaborations with of University of
                                                                                         Strategic Collaborations with The UniversityTheManchester’s
                                                                                                                  Manchester’s Faculty of Life
                                                                                                          Faculty of Engineering and Physical Sciences




Appendix C

Interdisciplinary Centre of Excellence




Nowgen – the Northwest Genetics Knowledge Park
Nowgen, a flagship project of the North West Science Council, is a partnership project of The Universities of
Manchester, Liverpool and Lancaster and the Central Manchester University Hospitals NHS Trust. The Department
of Health together with the Department of Trade & Industry established six Genetic Knowledge Parks in England
and Wales to ensure that the outcomes of human genetics research are successfully applied. In addition to core
funding of around £3.8M, Nowgen has won a major investment of £3.4M from the Northwest Development
Agency and the European Regional Development Fund to construct the Nowgen Centre – a landmark building
located in the centre of The University of Manchester campus, adjacent to the Faculty of Life Sciences.

Nowgen encourages entrepreneurship and provides platforms for technology transfer and commercial
exploitation of the findings of genetic research. Its strategic objectives are to:
• Improve the effectiveness and efficiency of the provision of genetic services in the region and the UK.
• Create a forum for education, engagement and dialogue around human genetics that will empower people
  to make decisions about health management.
• Provide a resource for the generation and provision of knowledge and insight in human genetics that will
  serve to improve understanding of genetics.
• Inform the development of national policy and ensure that the UK is better positioned to exploit the findings
  of genetics research.
• Support industry by providing advice, guidance, training and knowledge transfer in quality, regulatory, clinical,
  legal, ethical and social issues relating to human genetic information.
• Work actively with existing and emerging genomics initiatives in the North West to add value to the
  Government’s investment into the region’s emerging biotechnology cluster.

Nowgen has identified the following market opportunities to engage industry with genetic expertise and
to ensure optimum commercialisation and exploitation of genetic discoveries:
•  compliance with genetics standards for industry;
•  access to clinical samples with ethics approval and informed consent;
•  access to public opinion on the development of new genetics services and drugs;
•  new technology demonstration;
•  improved coherence between multiple research projects within the region.

Nowgen has gained Department of Health funding for several new research and service development projects,
including pharmacogenetics, and has developed new international collaborations. Nowgen’s senior staff
contribute to Canada’s genetics healthcare initiatives and have secured EU funding to participate in European
networks.
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Innovation in Action
Strategic Collaborations with The University of
Manchester’s Faculty of Life Sciences




Appendix D

Current Industrial Partners



                            The Faculty of Life Sciences currently enjoys partnerships of one form or
                            another with a number of companies, including:


                            • Advanced Medical Optics         • Interbrew
                            • Alcon Laboratories              • Intercytex
                            • Allergan                        • Johnson and Johnson
                            • Amgen (Applied Molecular        • Keeler Instruments
                              Genetics)                       • KuDOS Pharmaceuticals
                            • Arch UK Biocides                • Lonza Biologics
                            • Arrow Therapeutics              • Lorantis
                            • Aspect Vision Care              • Masterfoods (Mars)
                            • AstraZeneca                     • Medeval
                            • Aventis                         • Menicon
                            • BASF                            • Merck, Sharp and Dohme
                            • Bausch & Lomb                   • Motac Neuroscience
                            • Biocompatibles International    • Nationwide Laboratories
                            • Biogen                          • Neu Tech Pharma
                            • Boehringer Ingelheim Pharma     • Northern Foods
                            • Boots Opticians                 • Novartis Pharma
                            • Bristol-Meyer Squibb            • No. 7 Contact Lens
                            • British Nuclear Fuels           • Ocular Sciences
                            • Brucker                         • Ocutec
                            • Cambridge Antibody Technology   • Optical Express
                            • Celltech R&D                    • Ophtecs
                            • CIBA Vision                     • Pfizer
                            • Clariant UK                     • Pharmagene
                            • Colgate Palmolive               • Physiomics
                            • CooperVision                    • Procter and Gamble
                            • Covance Laboratories            • QinetiQ
                            • Dollond & Aitchison             • Quintiles
                            • DxS                             • Renovo
                            • Dynal Biotech                   • RHM Technology
                            • Eli Lilly & Company             • Roche Products
                            • Epistem                         • Sanofi-Synthelabo
                            • Essilor Contact Lenses          • Sauflon Pharmaceuticals
                            • F2G                             • Senexis
                            • Ferring Research                • Syngenta
                            • Gentronix                       • Unilever Research
                            • GlaxoSmithKline                 • Vernalis Research
                            • Hoya                            • Vialactiva Biosciences
                            • Hydron                          • Visioncare Research
                            • IMS Health                      • VisionTec
                            • Inpharmatica                    • Vistakon
                            • Intelisys                       • Xention Discovery
                                                                                                                    31
                                                                                                  Innovation in Action
                                                                        Strategic Collaborations with The University of
                                                                                  Manchester’s Faculty of Life Sciences




Appendix E

Key Contacts



To obtain further information, please do not hesitate to contact
members of our team:


                       Professor R. Alan North FRS
                       Vice-President & Dean
                       Faculty of Life Sciences
                       Michael Smith Building
                       The University of Manchester
                       Oxford Road, Manchester M13 9PT
                       Tel: +44(0)161 275 1497
                       Fax: +44(0)161 275 1498
                       r.a.north@manchester.ac.uk

                       Professor Martin J. Humphries
                       Associate Dean for Research
                       Faculty of Life Sciences
                       Michael Smith Building
                       The University of Manchester
                       Oxford Road, Manchester M13 9PT
                       Tel: +44(0)161 275 5071
                       Fax: +44(0)161 275 1505
                       martin.humphries@manchester.ac.uk

                       Professor Terry Brown
                       Associate Dean, Communication and External Affairs
                       Faculty of Life Sciences
                       Stopford Building
                       The University of Manchester
                       Oxford Road, Manchester M13 9PT
                       Tel: +44(0)161 306 4173
                       Fax: +44(0)161 236 0409
                       t.brown@manchester.ac.uk

                       Ms Jane Ratchford
                       Director
                       Business, Careers & Community Division
                       Crawford House
                       The University of Manchester
                       Booth Street East, Manchester M13 9QS
                       Tel: +44(0)161 275 2828
                       Fax: +44(0)161 285 2850
                       jane.ratchford@manchester.ac.uk
Produced by the Business, Careers & Community Division of The University of Manchester

Photography: Paul Cliff and Chris Moyse
courtesy of The University of Manchester