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					Our expertise and track record                  For further information:

CSIRO has state of the art scientific           Commercial contacts:
laboratories that bring together core           Dr. Megan Fisher
                                                Phone: 61 3 9545 2469
expertise in chemistry, biology and             Email: megan.fisher@csiro.au
materials science to create a unique
blend of skills and capability for              Dr. Darren Cundy
application to complex problems in              Phone: 61 3 9662 7450
                                                Email: darren.cundy@csiro.au
health and materials sciences.
CSIRO has delivered significant outcomes        Technical contacts:

in cardiovascular, ophthalmic, tissue           Dr. John Chiefari
                                                Phone: 61 3 9545 2508
engineering and specialty chemicals fields      Email: john.chiefari@csiro.au
through a range of spin-out and licensing
deals, and continues to deliver innovative      Dr. Graeme Moad
scientific outcomes in its areas of focus.      Phone: 61 3 9545 2509
                                                Email: graeme.moad@csiro.au
The polymer chemistry group at CSIRO
has pioneered the discovery and                 www.csiro.au/products/RAFT

development of RAFT technology, and is
pursuing the design of novel polymeric
systems with superior chemical, physical
and mechanical properties for application
in a range of areas.
Our work in this domain is protected
by an extensive intellectual property
portfolio, and is available for collaboration
and licensing




                                                                                           RAFT Technology

                                                                                           RAFT: The ultimate polymer building technology



                                                                                Dec 2010
RAFT: The ultimate polymer building technology


Together with the DuPont company, CSIRO has developed an innovative and world-class technology
known as RAFT (Reversible Addition-Fragmentation chain Transfer) which allows for the synthesis
of specifically crafted polymeric materials with enhanced properties and utility. The RAFT technology
allows for complete control over the size, shape and function of polymer molecules.

RAFT Technology                                                                          CSIRO is directly involved in
The RAFT technology is a very                RAFT technology can be used with a          • RAFT licensing (research and
sophisticated form of controlled free        wide range of monomers and monomer            commercial)
radical polymerisation.                      mixtures, and can be used in all modes
                                                                                         • RAFT research and development
                                             of free radical polymerisation, including
Often referred to as ‘living
                                             solution, emulsion and suspension           • RAFT commercialisation
polymerisation’, because it can be
                                             polymerisations.
stopped and restarted at anytime, this                                                                                                                                                                                                 > CSIRO scientists discussing RAFT
pioneering technology enables the            With freedom of this degree, the
                                                                                         RAFT applications
synthesis of tailored polymers with          polymer chemist can produce an              • agriculture                               Publications
unprecedented control over composition       unlimited array of tailored compositions                                                Further detailed information on RAFT
                                                                                         • drug delivery
and architecture.                            and complex architectures under                                                         technology may be found in the following                               RAFT: The most flexible CRP technology
                                             standard conditions.                        • biomedical materials
                                                                                                                                     references:
RAFT                                                                                     • personal care and cosmetics               • Living Free-Radical Polymerization by                                                             Traditional     Other CRP
RAFT technology offers the polymer
                                             The RAFT Process                            • lubricants and surfactants                  Reversible Addition-Fragmentation                                                                  polymer       technologies         Dendrimer
                                                                                                                                       Chain Transfer: The RAFT Process. J.                                            RAFT             technologies   (ATRP, nitroxides)    technology
chemist the benefit of being able to more    Implementing the RAFT process can
                                                                                         • decorative and architectural paints         Chiefari, et al, Macromolecules, 1998, 31,                   Size (MW)                                                                  
readily synthesise polymers:                 be as simple as introducing a suitable
                                             chain transfer agent – known as a                                                         5559-5562.                                                 Architecture                                                                 
• with predetermined molecular                                                           Patents                                     • Living Radical Polymerization by the                      Structure and
                                             RAFT Agent – into conventional free
  weight and narrow molecular weight                                                                                                                                                                                                                                            
                                             radical polymerisation, while employing     More than 3200 papers have been               RAFT Process. G. Moad, E. Rizzardo, S. H.                  composition
  distributions using a wide range of
                                             conventional plant and equipment.           published on RAFT developments,               Thang, Aust. J. Chem. 2005, 58, 379-410.            Ability to introduce
  monomers and reaction conditions
                                                                                         coupled with over 400 patents granted                                                                   Biodegradable                                                                   
                                             RAFT is a user- and, environmentally-                                                   • Living Radical Polymerization by the
• with reactive terminal groups that can                                                 to research and commercial institutions                                                                        linkages
                                             friendly process that does not require                                                    RAFT Process – A First Update.
  be purposely manipulated, including                                                    globally. Further detailed information on                                                            Biocompatibility                                                                  
                                             expensive and contaminating additives                                                     G. Moad, E. Rizzardo, S. H. Thang,
  further polymer extensions                                                             the RAFT technology can be found at:                                                               Surface properties                                                                 
                                             unlike other controlled free radical                                                      Aust. J. Chem. 2006, 59, 669-692.
• with complex architecture, including:                                                  www.csiro.au/products/RAFT.                                                                          Attachment and
                                             polymerisation processes.                                                               • Living Radical Polymerization by the                                                                                                    
                                                                                                                                                                                                  conjugation
  – A B diblock polymers                                                                                                               RAFT Process – A Second Update.
                                                                                                                                                                                            Structure-function
  – A B A triblock polymers                  RAFT Alliance                                                                             G. Moad, E. Rizzardo, S. H. Thang,                                                                                                    
                                                                                                                                                                                                  relationships
  – graft polymers                                                                                                                     Aust. J. Chem. 2009, 62, 1402–1472.
                                             The RAFT Alliance is a global community
  – star polymers
                                             for RAFT research, development and
  – gradient polymers
                                             commercialisation.
  – branched polymers
                                             To register your interst and gain access
• that is based on scaleable
                                             to the latest RAFT research and
  manufacturing processes utilising
                                             developments log onto:
  conventional processing equipment.
                                             www.csiro.au/products/RAFT




                                               > Creating new sophisticated polymer
                                               platforms for the improved delivery of
                                            small-molecule and biological therapeutics                                                                                              > Scientists developing polymers and plastics

				
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