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“Secondary metabolites from marine organisms as signals toxins (PDF download)

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					                                    Departmental Seminar
                                      Semester 1, 2010
                   Department of Chemistry & Biomolecular Sciences
                       Macquarie University, Sydney Australia
  The Speaker

                                                Prof. Dr. Ulf Bickmeyer
                                               Alfred Wegener Institute
                                               Bremerhaven, GERMANY

                    “Secondary metabolites from marine organisms
                    as signals, toxins and tools or cell physiology”

                          12 Noon February 25th Thursday
                            F7B 322 (CBMS Tea Room)
Abstract
Bromophenols and other brominated substances smell strongly and are commom in aquatic
environments and therefore can serve as chemical cues for organisms. Brominated secondary
metabolites additionally seem to permeate cellular membranes easily and therefore reach
intracellular target sites quickly. Pyrrole alkaloids, phenols and sesquiterpenes hydroquinones
interact with cellular processing, for example; calcium signalling. Others such as ageladine A
can be used as cellular dyes to unravel cellular trafficking and vesicle dynamics and to reveal
acidic tissues in transparent animals.


Five Representative Publications
1. Ulf Bickmeyer, Christoph Drechsler, Matthias Köck, Michael Assmann: Brominated pyrrole alkaloids from
   marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon. 44. 45-51. 2004
2. Adrian Wertz, Wolfgang Rössler, Malu Obermayer, Ulf Bickmeyer:Functional Neuroanatomy of the
   Rhinophore of Aplysia punctata. Front. Zool. 3. 6. 2006
3. Thomas Hassenklöver, Sabine Predehl, Jyotsna Pili, Michael Assmann, Ulf Bickmeyer: Bromophenols,
   present both in marine organisms and in industrial flame retardants, disturb cellular calcium signalling in
   neuroendocrine cells (PC12). Aquatic Toxicol. 76. 37-45. 2006
4. Ulf Bickmeyer, Achim Grube, Karl-Walter Klings, Matthias Köck: Ageladine A, a pyrrole-imidazole
   alkaloid from marine sponges, is a pH sensitive membrane permeable dye. Biochemical and Biophysical
   Research Communications. 373. 419–422. 2008 Corrigendum: 383(4), 519. 2009
5. Ulf Bickmeyer, Achim Grube, Karl-Walter Klings, Joesph R Pawlik, Matthias Köck, M. Siphonodictyal B1
   from a marine sponge increases intracellular calcium levels comparable to the Ca2+-ATPase (SERCA)
   inhibitor thapsigargin, Marine Biotechnology., doi:10.1007/s10126-009-9206-1 (in press)