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1
Burchill Partners Pty Limited
Wakame capsule coating
technology
SCRIPT
Videotape Documentary
Version 1
Produced by
Newton's Pty Ltd
3rd Draft Ð 30 June 2000 (AND FINAL)
VISION Ð ENGLISH JAPANESE GERMAN
Despite the advances of medical
1 science, there are still some aspects of
human health which have so far defied
traditional medicine.
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VISION Ð ENGLISH JAPANESE GERMAN
In poorer countries, medical treatment
2 is, if not primitive, costly to administer.
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The sheer size of some problems,
3 such as malaria, makes its eradication
by conventional means still a dream.
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The world takes for granted that many
4 drugs used in medicine, including
vaccines, must be given intravenously.
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The effectiveness of taking drugs orally
5 is severely limited by the gauntlet they
must travel, through the stomach acids.
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DIGEST3
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VISION Ð ENGLISH JAPANESE GERMAN
If the gauntlet could somehow be
6 overcome, it could be possible to
reduce dosages, cut pharmaceutical
costs and foster the development of
revolutionary drugs.
CYMB298
Captions overlay
REDUCE DOSAGES
CUT COSTS
DEVELOP NEW DRUGS
PAGE 7
VISION Ð ENGLISH JAPANESE GERMAN
At the Shimosoga Hospital in
7 Kanagawa, Japan, director general
Shintaro Tashiro was trying to
overcome the traumatic problems of
the aged and bed-ridden.
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VISION Ð ENGLISH JAPANESE GERMAN
He reasoned that toilet routine for the
8 patients and the quality of life for
hospital staff would improve
considerably if quantities of beneficial
Bifidus bacteria could be introduced live
into the small intestine Ð the hard part
was getting it safely through the acidic
stomach environment.
hospmachine.tif
capinglass.pict
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VISION Ð ENGLISH JAPANESE GERMAN
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VISION Ð ENGLISH JAPANESE GERMAN
If delicate material could be delivered
9 with precision, in a completely dry state,
to the small intestine, it could
revolutionise the pharmaceutical
industry and patient care.
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VISION Ð ENGLISH JAPANESE GERMAN
The means to this end has come from
10 one of the humblest sources
imaginable - common fresh seaweed,
called wakame.
seaweed.jpeg
www/kelp
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VISION Ð ENGLISH JAPANESE GERMAN
This seaweed changes its nature as the
11 surrounding environment swings from
acidic, through neutral or mild alkaline. It
was the key researchers were seeking.
www/seaweed2
www/seaweed1
This television story from Japan shows
12 the sheer simplicity of the process of
converting wakame into a protective
some of davidÕs new vision of the coating which could change the way the
close ups of the capsules Ð showing world takes its medicine.
the coated and uncoated together.
PAGE 13
VISION Ð ENGLISH JAPANESE GERMAN
Frisch gekochtes Reis und Miso-
Freshly steamed rice and miso soup Ð
13 a typically Japanese breakfast menu.
Suppe, das ist ein typisch
japanisches.
TV NEWS STORY Ð Here is wakame in the miso soup.
Hier ist Wakame in der Miso-
VISION AND SOUND This is especially prized. suppe. Das ist besonders
geschaetzt bei Japanern.
Es ist nat lich sehr bekannt,
Eating seaweed as a healthy food is of
14 course well known, but recent research Seetang wie Wakame als
Reformlebesnmittel zu essen,
has shown wakame can be usefully aber eine Untersuchung in letzter
employed when taking medicines and Zeit zeigte, dass Wakame sehr
health foods. effektiv sein kann, wenn man sie
bei der Einnahme der
Medikamente verwendet. Lass
mich erklaeren.
Fuer die beste Wirksamkeit
When taking medicines it would be
15 ideal if the capsule carried on safely einer Arznei,die oralerweise
eingenommen wuerde,
through the acidic stomach environment >waere es ideal, wenn die
to be absorbed at the top of the small Kapsel unversehrt im Magensaft
intestine. durchgefuehrt und
erst im obersten Teil des
Duenndarms absorbiert wird.
Aber in Wirklichkeit
loest sie sich meistens in der
starken Saeure im Magen.
PAGE 14
VISION Ð ENGLISH JAPANESE GERMAN
Es gibt ebenfalls
In reality, a great deal of medicine is
16 adversely affected by the strong acid of Kapselierungsmittel, die sich gar
nicht loesen und mit
the stomach, or in other cases, over- Exkrementen
protected capsules fail to dissolve at all ausgeschieden werden, wenn
and are expelled with the faeces. die Kapsel zu dick ueberzogen
ist.
Shintaro Tashiro, Leiter eines
It is said that Shintaro Tashiro, head of a
17 Japanese hospital, one day during a japanischen Krankenhaus, ist
eines Tages waerend des
meal, came up with the idea of coating Fruestuecks auf die Idee
capsules with wakame. gekommen, Kapseln mit
Wakame zuueberziehen. Sie
fragen wohl, warum Wakame?
Also, er hat bemerkt: waehrend
He noticed that wakame used with
18 vinegar dressing in seaweed salad Wakame im Seetangsalat mit
Essig voellig ihre Form und
completely retains its strength over Staerke behaelt, beginnt sie in
time, yet wakame in miso soup quickly einer Miso-suppe bald
begins to break apart. zuzerfallen.
In anderen Woertern
In other words, wakame resists
19 dissolution in the acid environment of gesagt,haelt Wakame in der
Saeure gegen Aufloesung fest,
the stomach, yet soon breaks down as aber zerfaellt sie bald, wenn die
the environment changes to neutral or to Umgebung, wie im oberen
weakly alkaline in the small intestine. Duenndarm,.sich zu neutral oder
leicht alkalisch veraendert.
It was a momentous observation.
20
PAGE 15
VISION Ð ENGLISH JAPANESE GERMAN
Sofort haben wir versucht,
This was the start of efforts to design a
21 drug delivery system using wakame. Wakame Kapsel herzustellen.
1. Einige frische Wakame
Beginning with the fresh wakame Ð
22 easily and cheaply obtainable in many nehmen.
countries Ð it goes into a blender for up 2. sie in den Mixer tun und fuer
to 30 seconds. 20 - 30 Sekunden arbeiten
3. pressen und die Fluessigkeit
The liquid is squeezed out, resulting in a
23 thick green fluid with jelly-like sieben. Man bekommt dicke
gruene gallertargige Fluessigkeit.
consistency. Sehr zaeh, nicht wahr?
4. dann Gelatine hinzufuegen
When it sets, it looks like this.
24 und in einen Behaelter
eingiessen, damit sie sich
befestigt.
5. wenn das fest wird, sieht das
wie ein Pudding aus.
Im Wasserbad loest das sich
It melts again, just like icecream. ItÕs
25 heated in hot water and medicine wie Eis. Dann tunken wir die
Kapseln darein, schuetteln
capsules can be dipped and then put Uebermass ab und auf die
out on trays to solidify. Tablette einzeln hinlegen, um
sie zu verfestigen. Wir kuehlen
die Kapseln langsam im
Stunden.
PAGE 16
VISION Ð ENGLISH JAPANESE GERMAN
Am naechsten Tag sehen sie so
Next day, they look like this,
26 completely dry and ready to go. aus: voellig trocken ohne
miteinander zu kleben. So sind
TheyÕre fragments of wakame sticking to Wakame Kapseln fertig. Sie
the surface. sehen hier noch Wakamefrocken
Auf der Oberflaeche.
Am naechsten Tag haben wir
Then came the test, to verify that
27 wakame capsules actually did carry on ein Experiment gemacht, um zu
beweisen, dass die Wakame
through to the small intestine without Kapseln wirklich bis zum
dissolving in the stomach. The process Duenndarm getragen werden,
was X-rayed. ohne sich im Magen
aufzuloesen.
HereÕs the situation, one hour after Wir haben einige
28 taking the capsules. Roentgenaufnahme von dem
Prozess gemacht.
The wakame capsule can be clearly Wollen wir die Roentgenbilder
29 seen undissolved in the stomach. nach einer Stunde ansehen. Die
unaufgeloeste Wakame Kapsel
ist ganz klar im Magen zu sehen.
Als naechstes benutzen wir
The effect is more clearly understood in
30 laboratory conditions, using artificial synthetisch hergestellte
Magensaft.
stomach acid.
PAGE 17
VISION Ð ENGLISH JAPANESE GERMAN
Im linken Glas ist eine Wakame
On the left is the wakame capsule. On
31 the right is an ordinary capsule. Kapsel, und im rechten Glas
eine herkoemmliche Kapsel.
Ob die Wakame Kapsel, wie
vorrausgesagt, ueberleben?
Nach einer Stunde ist die
One hour later the ordinary capsule has
32 easily dissolved and the contents are herkoemmliche Kapsel einfach
aufgeloest, und der Inhalt fliesst
oozing out. This is the inherent problem aus. Aber andererseits Seite ist
with all conventional capsules. die Wakame Kapsel ganz heil
geblieben.
The wakame capsule is unaffected.
33
Jetzt nun das wichtigste
Now for the most telling experiment.
34 The undissolved wakame capsule was Experiment: wir verlegen die im
Magensaft unaufgeloeste
transferred from the artificial stomach Wakame Kapsel ins syntetische
fluid to the artificial intestinal fluid. hergestellten Darmsaft. Wird
Sie sich aufloesen wie wir
erwarten?
PAGE 18
VISION Ð ENGLISH JAPANESE GERMAN
Nach einigen Minuten ist die
After 40 minutes it has obviously
35 broken down, releasing its contents to Kapsel offensichtlich zerfallen,
und das Inhalt der Kapsel ist
be absorbed in the small intestine. bereit, im Duenndarm absolbiert
zu werden .
Also hat sich unsere Wakame
The capsule works precisely as
36 Shintaro Tashiro planned Ð a significant Kapsel sich so verhalten wie
Shintaro Tashiro beabsichtigt
milestone in medical history. hat.
Jetzt wollen wir die Meinung
Some medical opinions -
37 vom Experten im medizinischen
Gebiet zuhoeren.
"Man versuchte bis jetzt ein
ÒInstead of protective coatings based
38 on exceedingly long and complex Material chemisch
zusammenzusetzen, das gegen
formulas, or inert compounds der Sauere widersteht aber im
compounds such as shellac, this Alkali sich aufloest. Aber das hat
wakame coating employs a traditional noch ungepruefte Faktoren bei
food element as the protective material. sich. Wakame, auf der anderen
In using a traditional food, this Seite, hat schon lange Tradition
technology is most significant.Ó als Lebensmittel, und ihre
Sicherheit ist bereits
bewiesen.Es ist sehr
aufschlussreich, Wakame als
Ueberzugsmittel zu benutzen."
Und hier ist unsere Wakame
Kapsel.
PAGE 19
VISION Ð ENGLISH JAPANESE GERMAN
Wird es moeglich, die Einnahme
ÒThe wakame capsule will be able to
39 reduce our intake of medicines by a der Arznei einigerma en zu
reduzieren?
significant amount, because it increases
the medicineÕs effectiveness.Ó
Oder wird es dazu beitragen,
In the future, we may find wakame
40 capsules employed as the ideal vehicle die Wirkung von Arznei zu
erhoehen?
for many medicines.
In Zukunft werden wir vielleicht
This is really a breakthroughÉ.an
41 invention born from the wisdom of viele Medikamenten sehen, die
mit Wakame Kapseln
everyday life. geschuetzt sind. Das waere eein
Durchbruch.
Es ist tatsaechlich eine Erfindung
END VIDEOTAPE SEGMENT im Alltagsleben.
PAGE 20
VISION Ð ENGLISH JAPANESE GERMAN
The significance of this discovery has
42 already triggered imaginative
responses from the makers of traditional
capsules, the pharmaceutical
companies and the medical profession.
Wakame capsule after
2 hours in stomach acid
PAGE 21
VISION Ð ENGLISH JAPANESE GERMAN
Wakame capsule after 2
hours in stomach acid and 1
hour in intestinal fluid
Wakame capsule after 2
hours in stomach acid and 2
hours in intestinal fluid
PAGE 22
VISION Ð ENGLISH JAPANESE GERMAN
Wakame capsule after 2
hours in stomach acid and 3
hours in intestinal fluid
The wakame capsule is the very model
43 of a sustainable invention, a low cost
natural seaweed, with no side effects
DavidÕs new footage and capable of being adapted by the
poorest countries for life-giving medical
programs.
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VISION Ð ENGLISH JAPANESE GERMAN
Its use in this hospital for carrying the
44 live bifidus bacteria safely to the very
top of the small intestine, has more than
adequately proven the theories. The
well being of the patients testifies to
that.
It is a solution the world has been
45 waiting for.
DavidÕs footage
PAGE 24
VISION Ð ENGLISH JAPANESE GERMAN
It can bring medicine, like the malaria
46 vaccines, into the reach of all people.
PAGE 25
VISION Ð ENGLISH JAPANESE GERMAN
It will throw new light on the use of
47 drugs now administered through
injection.
Run DavidÕs footage, with overlay
of needle.
PAGE 26
VISION Ð ENGLISH JAPANESE GERMAN
It will cause a re-examination of the
48 value of medicines used in cancer
treatment and heart cases. It even has
a role in veterinary science.
With wakame, the possibilities and the
49 opportunities appear to be endless.
(ANIMATED VERSION)
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VISION Ð ENGLISH JAPANESE GERMAN
The Wakame capsule technology is
50 endorsed by the Zero Emissions
Research Initiative, known as the ZERI
Foundation, for its potential contribution
to world health.
CAPTION:
Gunter Pauli
Head of the ZERI Foundation
Geneva
PAGE 28
VISION Ð ENGLISH JAPANESE GERMAN
ZERI heralds the start of the next
51 industrial revolution, in which industry
mimics natureÕs sustainable cycles.
PAGE 29
VISION Ð ENGLISH JAPANESE GERMAN
Human kind, rather than expecting the
52 earth to produce more, learns to do
more with what the earth produces.
The Wakame capsule could be at the
53 forefront of this revolution.
From DavidÕs footage
PAGE 30
VISION Ð ENGLISH JAPANESE GERMAN
CAPTION
ZERI Foundation
Email:
phillip@zeri.org
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VISION Ð ENGLISH JAPANESE GERMAN
Produced by
burchilllogoamended
Gold Coast Australia
www.burchillpartners.com.au
in association with
newtons@onthenet.com.au
Television story
Thanks to Nihon
Television Tokyo
ã NTV 2000
PAGE 32
VISION Ð ENGLISH JAPANESE GERMAN
CAPTION
The Wakame technology is
showcased at Expo 2000
Hanover, Germany in the
ZERI pavillion.
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