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ACRYLAMIDE

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					 MATERIAL SAFETY DATA SHEET                                                    ACRYLAMIDE
 PRODUCT CODE NUMBER(S): 0730-5, 0731-5

PRODUCT IDENTIFICATION                                            FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: Acrylamide;                           Flammability: Non flammable, but decomposes violently
Propenamide; Acrylic acid amide; Acrylic amide;                   above 85°C, releasing highly flammable/explosive hydrogen
Ethylenecarboxamide                                               gas. In fire situation, grave danger of explosion.
Chemical Family: Unsaturated aliphatic amide                      Extinguishing Media: Water spray, carbon dioxide, dry
Chemical Formula: C3H5NO                                          chemical powder, alcohol-resistant foam, polymer foam.
                                                                  Fight fire from upwind, from a safe distance. Firefighters
Product Use: Laboratory reagent                                   must wear protective equipment (NIOSH/OSHA approved
Manufacturer’s Name and Address:                                  self-contained breathing apparatus) and clothing sufficient to
      Caledon Laboratories Ltd.                                   prevent inhalation of mists or vapours, and contact with skin
      40 Armstrong Avenue                                         and eyes (encapsulating chemical splash suit-Bunker Gear
      Georgetown, Ontario L7G 4R9                                 will not be adequate). Use water spray or fog to cool
                                                                  fire-exposed containers, from as far away as possible. Con-
Telephone No: (905) 877-0101                                      tainers may explode in heat of fire; withdraw immediately in
Fax No: (905) 877-6666                                            case of rising sound from vent or discoloration of tank.
Emergency Telephone No: CANUTEC (613) 996-6666                    Flash Point (Method Used): Not applicable
                                                                  Autoignition Temperature: 240°C
HAZARDOUS INGREDIENTS OF MATERIALS                                Upper Flammable Limit (% by volume): Not applicable
 Ingredients             %       TLV Units        CAS No.         Lower Flammable Limit (% by volume): Not applicable
                                            3                     Hazardous Combustion Products: Flammable/explosive
Acrylamide               99      0.03 mg/m       79-06-1          hydrogen gas, ammonia gas, COx, NOx
                               (includes skin exposure)
                                                                  Sensitivity to Impact: None identified
PHYSICAL DATA                                                     Sensitivity to Static discharge: Decomposes violently
                                                                  above 85°C, or on contact with oxidizers, releasing highly
Physical State: Solid                                             flammable/explosive hydrogen gas, which is readily ignited
Odour and Appearance: White crystalline powder, odour-            by static discharge.
less
Odour Threshold (ppm): Not applicable                             TOXICOLOGICAL PROPERTIES AND HEALTH DATA
Vapour Pressure (mm Hg): 0.007 mm Hg @ 25°C                        Toxicological Data:
Vapour Density (Air = 1): 2.45
                                                                  LD50: (oral, rat) 124 mg/kg; (dermal, rat) 400 mg/kg
Evaporation Rate: Not available
                                                                  LC50: Not available
Boiling Point (C°): 87°C @ 2 mm Hg; 125°C @ 25 mm Hg
Melting Point (C°): 85°C (decomposes/polymerizes)                  Effects of Acute Exposure to Product:
pH: 5.0 to 6.5 (50% aqueous solution)
                                                                                                  .
                                                                  Inhaled: Irritating to nose and throat. Highly toxic. Skin ex-
Specific Gravity: 1.12 @ 30°                                      posure is the usual cause of toxicity in the workplace, but, as
Coefficient of Water/Oil distribution: LogP (oct) -0.67           the solid sublimes, inhalation can be a hazard. Acute poi-
                                                                  soning usually leads to CNS disturbances such as
SHIPPING DESCRIPTION                                              drowsiness, tingling sensations, fatigue, weakness, stum-
                                                                  bling, slurred speech and shaking. Neurotoxity may occur
UN: 2074                                                          after repeated low dose exposure or several weeks after an
T.D.G. Class: 6.1                                                 acute exposure, causing muscular weakness, paresthesia,
Pkg. Group: III                                                   numbness in hands, feet, lower legs, and lower arms, un-
                                                                  steadiness, and difficulties in walking and standing.
REACTIVITY DATA                                                   Autonomic nervous system involvement is indicated by ex-
                                                                  cessive sweating, peripheral vasodilation and difficulties in
Chemical Stability: Stable at room temperature but poly-          micturation and defecation.
merizes violently at 85°C, or on exposure to ultraviolet light,   In contact with skin: Very toxic, irritating. Readily ab-
releasing flammable hydrogen and toxic ammonia gases.             sorbed by skin causing neurotoxicity (see “Inhaled”. Onset of
Incompatibility with other substances: May polymerize             symptoms may be delayed for several days or weeks.
violently on contact with oxidizers, e.g. peroxides. May de-      In contact with eyes: No human information available.
compose vigorously with acids or bases, producing                 Based on animal information, probably moderate irritant,
ammonia salts and acrylic acid. Sensitive to heat, sunlight,      causing redness, tearing, temporary pain. Severe
and moisture . Not corrosive to metals, but avoid contact         overexposure can lead to absorption with neurotoxicity as in
with iron, steel, copper, aluminum, brass, and bronze.            “Inhaled”.
Reactivity: Avoid exposure to air, heat, sunlight, moisture.      Ingested: Highly toxic, although ingestion is not the typical
Avoid contact with oxidizers, acids, bases, metals, all in-       route of industrial exposure. Symptoms as in “Inhaled”.
compatible materials, generation of dust.
Hazardous Decomposition Products: Flammable hydro-
gen gas, ammonia gas, COx, NOx
 MSDS                                ACRYLAMIDE
CODE: 0730-5, 0731-5
 Effects of Chronic Exposure to Product:                               Storage Requirements: Store in sturdy, labelled containers
                                                                       (usually shipping containers), at a height convenient for handling.
Is absorbed rapidly and distributed widely in the body. Crosses        Store in a cool, dry, well-ventilated area, out of direct sunlight, and
placental barrier, occurs in breast milk. Accumulates temporarily,     away from heat and ignition sources, and incompatible materials.
but most is broken down within a day. Repeated exposure to low         Storage facilities should be made of fire-resistant materials, with
levels of dust has resulted in neurotoxicity in humans. Primary        raised sills and trenching to safe location. and with appropriate fire
route of exposure is skin absorption, but inhalation and ingestion     extinguishers and cleanup equipment nearby. Protect from dam-
can contribute to overall exposure. Symptoms may be delayed 2          age and inspect frequently for damage or leaking.
weeks to 2 months; they include tiredness, weakness in hands
and feet, tremor, dizziness, muscular inco-ordination, poor mem-       FIRST AID MEASURES
ory, confusion, slurred speech, vision changes, excessive
sweating, peripheral vasodilation, urinary system changes,              Specific Measures:
weight loss. Recovery may be good, but may take months to              Eyes: Allow eyes to water naturally for a few minutes to dislodge
years depending on severity and duration of exposure.                  particle. Do not allow victim to rub eyes. Wear protective gloves to
Repeated skin exposure can cause redness, blistering and peel-         avoid contact. Flush eyes with gently running water, holding eye-
ing of skin, particularly on hands and feet. May also cause skin       lids open during flushing, for at least ten (10) minutes, or until no
sensitization.                                                         trace of chemical remains. Take care not to flush contaminated
                                                                       water into unaffected eye. Get medical attention.
Carcinogenicity: Evidence of carcinogenicity in animals; inade-        Skin: Remove contaminated clothing under running water. Wear
quate evidence in humans at present. IARC class: 2A (probable          impervious gloves to avoid contact during first aid procedures. Im-
human carcinogen). ACGIH class: A3 (animal carcinogen).                mediately flush affected areas with soap and running water for at
Teratogenicity: No human information available. Inconclusive           least ten (10) minutes, or until no trace of chemical remains. Ob-
animal information: som e embryotoxic effects at doses affecting       tain medical advice immediately. Completely decontaminate
parents; no teratogenic effects in animal studies.                     clothing before reuse. DIscard contaminated shoes & leather
Reproductive Effects: No human information available. Some             goods.
adverse effects in male animals.                                       Inhalation: IMMEDIATELY move victim to fresh air (caution must
Mutagenicity: In animal studies, caused mutations in reproduc-         be observed by rescuers to avoid exposure). Give oxygen for
tive cells and blood-forming cells.                                    breathing difficulty. Get medical attention immediately.
Synergistic Products: None known                                       Ingestion: If victim is alert and NOT convulsing, give 1 to 2
                                                                       glasses of water to dilute material. DO NOT induce vomiting. If
PREVENTIVE MEASURES                                                    spontaneous vomiting occurs, have victim lean forward with head
                                                                       down to avoid breathing in of vomitus, rinse mouth and administer
Engineering Controls: Local exhaust ventilation required.              more water. Get medical attention IMMEDIATELY.
Respiratory Protection: Dust mask, fume hood. For concen-              Notes to Physician: Either acute or chronic exposure may lead
trations above the recommended exposure limit (0.03 mg/m3), or         to weak or absent reflexes, positive Romberg’s sign, loss of vibra-
for unknown concentrations, use positive pressure, full                tion and position senses, numbness and tingling of the limbs, and
face-piece self-contained breathing apparatus, or positive pres-       peeling of the skin of the fingertips. Antidote: Pyridoxine (vitamin
sure, full face-piece supplied air respirator with auxiliary postive   B6), pyruvate, and N-acetylcysteine have been used to reduce the
pressure self-contained breathing apparatus.                           toxicity of acrylamide in experimental studies, but are unproven.
Eye Protection: Chemical safety goggles and/or face shield.
Skin Protection: 30-70% (no inofrmation available for solid).          REFERENCES USED
Butyl rubber, TychemÔBR/LV, TychemÔSL, TychemÔTK                       CCINFO disc: CCINFO
gloves Coveralls, boots, other clothing sufficient to prevent any
contact.                                                               Budavari: The Merck Index, 12th ed., 1997
Other Personal Protective Equipment: Safety shower and                 Royal Society of Chemistry: Chemcial Safety Data Sheets, Vol. 4A,
eye-wash fountain in work area.                                        1991
Leak and Spill Procedure: Evacuate area. Eliminate all igni-           Sax, Lewis: Hawley’s Condensed Chemical Dictionary, 11th ed.,
tion sources. Cleanup personnel must be thoroughly trained in          1987
the handling of hazardous materials, and must wear protective          Suppliers’ Material Safety Data Sheets
equipment and clothing sufficient to prevent any inhalation of va-
pours or mists and any contact with skin and eyes. Stop or
reduce leak if safe to do so. Prevent material from entering sew-      ADDITIONAL INFORMATION
ers or waterways. Mix with inert absorbent, transfer to container      Date Issued: February 20, 1990
and arrange removal by disposal company. Contaminated absor-
                                                                       Revision: October 2008
bent may pose the same hazards as the chemical; treat with
extreme caution. Ventilate area and flush thoroughly with plenty       MSDS: 0730-5, 0731-5
of running water.                                                      WHMIS Designation: D1B; D2A
Waste Disposal: Follow all federal, provincial and local regula-
tions for disposal.                                                    Prepared by: Caledon Laboratories Ltd. (905) 877-0101
Handling Procedures and Equipment: VERY TOXIC,                         Caledon Laboratories Ltd. believes the information contained herein
NEUROTOXIN, CARCINOGEN, MUTAGEN, REPRODUCTIVE                          is reliable and accurate. Caledon makes no warranty with respect
TOXIN. Personnel working with this product must be thoroughly          thereto and expressly disclaims all liability for reliance thereon. Such
trained in its hazards and its safe use and must wear appropriate      information is solely for your consideration, investigation, and verifi-
protective equipment and clothing. Prevent all eye and skin con-
tact. Avoid generating or inhaling mist or dust. Use the smallest      cation.
amount possible for the purpose, in an area with adequate venti-
lation. Keep work area clean and free from all extraneous
materials. Use work surfaces that can be easily decontami-
nated. Empty containers will contain hazardous residues; treat
with caution.

				
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