MATERIAL SAFETY DATA SHEET ACRYLAMIDE PRODUCT CODE NUMBER(S): 0730-5, 0731-5 PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA Chemical Name and Synonyms: Acrylamide; Flammability: Non flammable, but decomposes violently Propenamide; Acrylic acid amide; Acrylic amide; above 85°C, releasing highly flammable/explosive hydrogen Ethylenecarboxamide gas. In fire situation, grave danger of explosion. Chemical Family: Unsaturated aliphatic amide Extinguishing Media: Water spray, carbon dioxide, dry Chemical Formula: C3H5NO chemical powder, alcohol-resistant foam, polymer foam. Fight fire from upwind, from a safe distance. Firefighters Product Use: Laboratory reagent must wear protective equipment (NIOSH/OSHA approved Manufacturer’s Name and Address: self-contained breathing apparatus) and clothing sufficient to Caledon Laboratories Ltd. prevent inhalation of mists or vapours, and contact with skin 40 Armstrong Avenue and eyes (encapsulating chemical splash suit-Bunker Gear Georgetown, Ontario L7G 4R9 will not be adequate). Use water spray or fog to cool fire-exposed containers, from as far away as possible. Con- Telephone No: (905) 877-0101 tainers may explode in heat of fire; withdraw immediately in Fax No: (905) 877-6666 case of rising sound from vent or discoloration of tank. Emergency Telephone No: CANUTEC (613) 996-6666 Flash Point (Method Used): Not applicable Autoignition Temperature: 240°C HAZARDOUS INGREDIENTS OF MATERIALS Upper Flammable Limit (% by volume): Not applicable Ingredients % TLV Units CAS No. Lower Flammable Limit (% by volume): Not applicable 3 Hazardous Combustion Products: Flammable/explosive Acrylamide 99 0.03 mg/m 79-06-1 hydrogen gas, ammonia gas, COx, NOx (includes skin exposure) Sensitivity to Impact: None identified PHYSICAL DATA Sensitivity to Static discharge: Decomposes violently above 85°C, or on contact with oxidizers, releasing highly Physical State: Solid flammable/explosive hydrogen gas, which is readily ignited Odour and Appearance: White crystalline powder, odour- by static discharge. less Odour Threshold (ppm): Not applicable TOXICOLOGICAL PROPERTIES AND HEALTH DATA Vapour Pressure (mm Hg): 0.007 mm Hg @ 25°C Toxicological Data: Vapour Density (Air = 1): 2.45 LD50: (oral, rat) 124 mg/kg; (dermal, rat) 400 mg/kg Evaporation Rate: Not available LC50: Not available Boiling Point (C°): 87°C @ 2 mm Hg; 125°C @ 25 mm Hg Melting Point (C°): 85°C (decomposes/polymerizes) Effects of Acute Exposure to Product: pH: 5.0 to 6.5 (50% aqueous solution) . Inhaled: Irritating to nose and throat. Highly toxic. Skin ex- Specific Gravity: 1.12 @ 30° posure is the usual cause of toxicity in the workplace, but, as Coefficient of Water/Oil distribution: LogP (oct) -0.67 the solid sublimes, inhalation can be a hazard. Acute poi- soning usually leads to CNS disturbances such as SHIPPING DESCRIPTION drowsiness, tingling sensations, fatigue, weakness, stum- bling, slurred speech and shaking. Neurotoxity may occur UN: 2074 after repeated low dose exposure or several weeks after an T.D.G. Class: 6.1 acute exposure, causing muscular weakness, paresthesia, Pkg. Group: III numbness in hands, feet, lower legs, and lower arms, un- steadiness, and difficulties in walking and standing. REACTIVITY DATA Autonomic nervous system involvement is indicated by ex- cessive sweating, peripheral vasodilation and difficulties in Chemical Stability: Stable at room temperature but poly- micturation and defecation. merizes violently at 85°C, or on exposure to ultraviolet light, In contact with skin: Very toxic, irritating. Readily ab- releasing flammable hydrogen and toxic ammonia gases. sorbed by skin causing neurotoxicity (see “Inhaled”. Onset of Incompatibility with other substances: May polymerize symptoms may be delayed for several days or weeks. violently on contact with oxidizers, e.g. peroxides. May de- In contact with eyes: No human information available. compose vigorously with acids or bases, producing Based on animal information, probably moderate irritant, ammonia salts and acrylic acid. Sensitive to heat, sunlight, causing redness, tearing, temporary pain. Severe and moisture . Not corrosive to metals, but avoid contact overexposure can lead to absorption with neurotoxicity as in with iron, steel, copper, aluminum, brass, and bronze. “Inhaled”. Reactivity: Avoid exposure to air, heat, sunlight, moisture. Ingested: Highly toxic, although ingestion is not the typical Avoid contact with oxidizers, acids, bases, metals, all in- route of industrial exposure. Symptoms as in “Inhaled”. compatible materials, generation of dust. Hazardous Decomposition Products: Flammable hydro- gen gas, ammonia gas, COx, NOx MSDS ACRYLAMIDE CODE: 0730-5, 0731-5 Effects of Chronic Exposure to Product: Storage Requirements: Store in sturdy, labelled containers (usually shipping containers), at a height convenient for handling. Is absorbed rapidly and distributed widely in the body. Crosses Store in a cool, dry, well-ventilated area, out of direct sunlight, and placental barrier, occurs in breast milk. Accumulates temporarily, away from heat and ignition sources, and incompatible materials. but most is broken down within a day. Repeated exposure to low Storage facilities should be made of fire-resistant materials, with levels of dust has resulted in neurotoxicity in humans. Primary raised sills and trenching to safe location. and with appropriate fire route of exposure is skin absorption, but inhalation and ingestion extinguishers and cleanup equipment nearby. Protect from dam- can contribute to overall exposure. Symptoms may be delayed 2 age and inspect frequently for damage or leaking. weeks to 2 months; they include tiredness, weakness in hands and feet, tremor, dizziness, muscular inco-ordination, poor mem- FIRST AID MEASURES ory, confusion, slurred speech, vision changes, excessive sweating, peripheral vasodilation, urinary system changes, Specific Measures: weight loss. Recovery may be good, but may take months to Eyes: Allow eyes to water naturally for a few minutes to dislodge years depending on severity and duration of exposure. particle. Do not allow victim to rub eyes. Wear protective gloves to Repeated skin exposure can cause redness, blistering and peel- avoid contact. Flush eyes with gently running water, holding eye- ing of skin, particularly on hands and feet. May also cause skin lids open during flushing, for at least ten (10) minutes, or until no sensitization. trace of chemical remains. Take care not to flush contaminated water into unaffected eye. Get medical attention. Carcinogenicity: Evidence of carcinogenicity in animals; inade- Skin: Remove contaminated clothing under running water. Wear quate evidence in humans at present. IARC class: 2A (probable impervious gloves to avoid contact during first aid procedures. Im- human carcinogen). ACGIH class: A3 (animal carcinogen). mediately flush affected areas with soap and running water for at Teratogenicity: No human information available. Inconclusive least ten (10) minutes, or until no trace of chemical remains. Ob- animal information: som e embryotoxic effects at doses affecting tain medical advice immediately. Completely decontaminate parents; no teratogenic effects in animal studies. clothing before reuse. DIscard contaminated shoes & leather Reproductive Effects: No human information available. Some goods. adverse effects in male animals. Inhalation: IMMEDIATELY move victim to fresh air (caution must Mutagenicity: In animal studies, caused mutations in reproduc- be observed by rescuers to avoid exposure). Give oxygen for tive cells and blood-forming cells. breathing difficulty. Get medical attention immediately. Synergistic Products: None known Ingestion: If victim is alert and NOT convulsing, give 1 to 2 glasses of water to dilute material. DO NOT induce vomiting. If PREVENTIVE MEASURES spontaneous vomiting occurs, have victim lean forward with head down to avoid breathing in of vomitus, rinse mouth and administer Engineering Controls: Local exhaust ventilation required. more water. Get medical attention IMMEDIATELY. Respiratory Protection: Dust mask, fume hood. For concen- Notes to Physician: Either acute or chronic exposure may lead trations above the recommended exposure limit (0.03 mg/m3), or to weak or absent reflexes, positive Romberg’s sign, loss of vibra- for unknown concentrations, use positive pressure, full tion and position senses, numbness and tingling of the limbs, and face-piece self-contained breathing apparatus, or positive pres- peeling of the skin of the fingertips. Antidote: Pyridoxine (vitamin sure, full face-piece supplied air respirator with auxiliary postive B6), pyruvate, and N-acetylcysteine have been used to reduce the pressure self-contained breathing apparatus. toxicity of acrylamide in experimental studies, but are unproven. Eye Protection: Chemical safety goggles and/or face shield. Skin Protection: 30-70% (no inofrmation available for solid). REFERENCES USED Butyl rubber, TychemÔBR/LV, TychemÔSL, TychemÔTK CCINFO disc: CCINFO gloves Coveralls, boots, other clothing sufficient to prevent any contact. Budavari: The Merck Index, 12th ed., 1997 Other Personal Protective Equipment: Safety shower and Royal Society of Chemistry: Chemcial Safety Data Sheets, Vol. 4A, eye-wash fountain in work area. 1991 Leak and Spill Procedure: Evacuate area. Eliminate all igni- Sax, Lewis: Hawley’s Condensed Chemical Dictionary, 11th ed., tion sources. Cleanup personnel must be thoroughly trained in 1987 the handling of hazardous materials, and must wear protective Suppliers’ Material Safety Data Sheets equipment and clothing sufficient to prevent any inhalation of va- pours or mists and any contact with skin and eyes. Stop or reduce leak if safe to do so. Prevent material from entering sew- ADDITIONAL INFORMATION ers or waterways. Mix with inert absorbent, transfer to container Date Issued: February 20, 1990 and arrange removal by disposal company. Contaminated absor- Revision: October 2008 bent may pose the same hazards as the chemical; treat with extreme caution. Ventilate area and flush thoroughly with plenty MSDS: 0730-5, 0731-5 of running water. WHMIS Designation: D1B; D2A Waste Disposal: Follow all federal, provincial and local regula- tions for disposal. Prepared by: Caledon Laboratories Ltd. (905) 877-0101 Handling Procedures and Equipment: VERY TOXIC, Caledon Laboratories Ltd. believes the information contained herein NEUROTOXIN, CARCINOGEN, MUTAGEN, REPRODUCTIVE is reliable and accurate. Caledon makes no warranty with respect TOXIN. Personnel working with this product must be thoroughly thereto and expressly disclaims all liability for reliance thereon. Such trained in its hazards and its safe use and must wear appropriate information is solely for your consideration, investigation, and verifi- protective equipment and clothing. Prevent all eye and skin con- tact. Avoid generating or inhaling mist or dust. Use the smallest cation. amount possible for the purpose, in an area with adequate venti- lation. Keep work area clean and free from all extraneous materials. Use work surfaces that can be easily decontami- nated. Empty containers will contain hazardous residues; treat with caution.