Pu-Erh Tea

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					Pu-Erh Tea
       Pu-erh, Pu'er tea, Puer tea or Bolay tea is a type of tea made from a "large leaf" variety of the tea plant
       Camellia sinensis and named after Pu'er county near Simao, Yunnan, China.


General Precautions
       Allergy
       Although rare, allergic reactions to herbal tea may occur. If these reactions occur, stop taking herbal tea
       and seek emergency medical attention if you experience symptoms of a serious allergic reaction
       including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives

       Health Conditions
       Herbal tea may interfere with the effects of anti-coagulants such as warfarin (Coumadin).

       Other
       This product contains small amounts of Caffeine.


Studies and Research
The following information has been sourced and re-produced from independent studies and researches
and publications, in an effort to provide information for medical professionals.


       Mechanisms of hypolipidemic and anti-obesity effects of tea and
       tea polyphenols.
       Lin JK, Lin-Shiau SY.
       Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
       jklin@ha.mc.ntu.edu.tw

       Among the health-promoting effects of tea and tea polyphenols, the cancer-chemopreventive effects in
       various animal model systems have been intensively investigated; meanwhile, the hypolipidemic and
       antiobesity effects in animals and humans have also become a hot issue for molecular nutrition and food
       research. It has been demonstrated that the body weights of rats and their plasma triglyceride,
       cholesterol, and LDL-cholesterol have been significantly reduced by feedings of oolong, black, pu-erh,
       and green tea leaves to the animals. It has been suggested that the inhibition of growth and suppression
       of lipogenesis in MCF-7 breast cancer cells may be through down-regulation of fatty acid synthase gene
       expression in the nucleus and stimulation of cell energy expenditure in the mitochondria. The
       experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by
       tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal
       transduction pathways.

       PMID: 16404708 [PubMed - indexed for MEDLINE]



       Comparative studies on the hypolipidemic and growth
       suppressive effects of oolong, black, pu-erh, and green tea
       leaves in rats.
       Kuo KL, Weng MS, Chiang CT, Tsai YJ, Lin-Shiau SY, Lin JK.
       Wun-Shan Branch, Tea Research and Extension Station, Taipei, Taiwan.
The four major commercial teas, oolong, black, pu-erh, and green teas, have been manufactured in
southeast Asia. In this study, we evaluated the growth suppressive and hypolipidemic effect of these four
different tea leaves by oral feeding to male Sprague-Dawley rats for 30 weeks. The results showed that
the suppression of body weights of tea leaves-fed groups were in the order: oolong tea > pu-erh tea >
black tea > green tea. Pu-erh tea and oolong tea could lower the levels of triglyceride more significantly
than that of green tea and black tea, but pu-erh tea and green tea were more efficient than oolong tea
and black tea in lowering the level of total cholesterol. In lipoprotein, 4% pu-erh tea could increase the
level of HDL-C and decrease the level of LDL-C, but other teas simply decrease the levels of both. The
activity of antioxidant enzyme SOD is increased in all tea-fed groups as compared to the basal diet-fed
group. Finally, relative weight ratios of liver to epididylmal adipose tissue were lower in feeding oolong
tea and pu-erh tea groups. On the basis of these findings, it seemed that the fully fermented pu-erh and
black tea leaves and partially fermented oolong tea leaves were more effective on their growth
suppressive and hypolipidemic effects as compared to the nonfermented green tea leaves.

PMID: 15656692 [PubMed - indexed for MEDLINE]



Pu-erh tea supplementation suppresses fatty acid synthase
expression in the rat liver through downregulating Akt and JNK
signalings as demonstrated in human hepatoma HepG2 cells.
Chiang CT, Weng MS, Lin-Shiau SY, Kuo KL, Tsai YJ, Lin JK.
Institute of Biochemistry and Molecular Biology, College of Medicine National Taiwan University, Taipei.

Fatty acid synthase (FAS) is a key enzyme of lipogenesis. Overexpression of FAS is dominant in cancer
cells and proliferative tissues. The expression of FAS in the livers of rats fed pu-erh tea leaves was
significantly suppressed. The gains in body weight, levels of triacylglycerol, and total cholesterol were
also suppressed in the tea-treated rats. FAS expression in hepatoma HepG2 cells was suppressed by
the extracts of pu-erh tea at both the protein and mRNA levels. FAS expression in HepG2 cells was
strongly inhibited by PI3K inhibitor LY294002 and JNK inhibitor II and slightly inhibited by p38 inhibitor
SB203580 and MEK inhibitor PD98059, separately. Based on these findings, we suggest that the
suppression of FAS in the livers of rats fed pu-erh tea leaves may occur through downregulation of the
PI3K/AKt and JNK signaling pathways. The major components of tea that have been demonstrated to be
responsible for the antiobesity and hypolipidemic effects are catechins, caffeine, and theanine. The
compositions of catechins, caffeine, and theanine varied dramatically in pu-erh, black, oolong, and green
teas. The active principles and molecular mechanisms that exerted these biological effects in pu-erh tea
deserve future exploration.

PMID: 16925113 [PubMed - indexed for MEDLINE]

				
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posted:2/15/2011
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