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									AB
                                          MATERIAL SAFETY DATA SHEET
NITROUS OXIDE
                                                        DATE: March 2008        Ingestion                 Depletion of methionine has been implicated in the
1   PRODUCT AND COMPANY IDENTIFICATION                                                                    neurological deficit seen in chronic abusers of nitrous
                                                                                                          oxide.
PRODUCT IDENTIFICATION
Product Name                      Nitrous Oxide                                 4    FIRST AID MEASURES
Chemical Formula                  N2 O                                          Prompt medical attention is mandatory in all cases of overexposure to nitrous
Trade Names                       Medical Nitrous Oxide, Compressed             oxide. Rescue personnel should be cognisant of extreme fire hazard
                                  Nitrous Oxide, Instrument Grade               associated with nitrous oxide-rich atmospheres. Inapplicable, unwitting or
                                  NitroBoost                                    deliberate inhalation of nitrous oxide will result in unconsciousness, passing
Colour Coding                     Medical Nitrous Oxide                         through stages of increasing light-headedness and intoxication, and, if the
                                  French Blue (F.09) body with White            victim were to be within a confined space, death from anoxia could result.
                                  stencilling.                                  The treatment is removal to fresh air, and if necessary, the use of an oxygen
                                  Nitrous Oxide, Instrument Grade               resuscitator.
                                  French Blue (F.09) body with the              Eye Contact               No known effect.
                                  “Instrument Grade” logo affixed centrally     Skin Contact             No known effect.
                                  to the body of the cylinder.
                                                                                Ingestion                Inapplicable, unwitting or deliberate inhalation of
                                  Nitroboost French Blue (F.09) body with a
                                                                                                         nitrous oxide will result in unconsciousness, passing
                                  yellow shoulder, and “Nitroboost” Label
                                                                                                         through stages of increasing light-headedness and
                                  stating “Toxic not for Medical use”
                                                                                                         intoxication, and, if the victim were to be within a
Valves                            Medical & Instrument Grades 3SN – Brass
                                                                                                         confined space, death from anoxia could result. The
                                  11/16 inch × 20t.p.i. male. Nitroboost
                                                                                                         treatment is removal to fresh air, and if necessary, the
                                  Neriki – Brass 5/8 inch left hand female,
                                                                                                         use of an oxygen resuscitator.
                                  positive pressure.
Company Identification            African Oxygen Limited                        5    FIRE FIGHTING MEASURES
                                  23 Webber Street
                                  Johannesburg, 2001                            Extinguishing media     As nitrous oxide is non-flammable but strongly
                                  Tel. No: (011) 490-0400                                               supports combustion, the correct type of
                                  Fax No: (011) 490-0506                                                extinguishing media should be used depending on
                                                                                                        the combustible material involved.
2   COMPOSITION/INFORMATION ON INGREDIENTS                                      Specific Hazards        Nitrous oxide vigorously accelerates combustion.
Chemical Name    Nitrous Oxide                                                                          Materials that would not normally burn in air could
Chemical Family  Oxidant                                                                                combust vigorously in atmospheres having high
CAS No.          10024-97-2                                                                             concentrations of nitrous oxide.
UN No.           1070                                                           Emergency Actions       If possible, shut off the source of escaping Nitrous
ERG No           122                                                                                    oxide. Evacuate area. All cylinders should be
Hazchem Warning  5 A Non-flammable Compressed Gas                                                       removed from the vicinity of the fire. Cylinders
                                                                                                        that cannot be removed should be cooled with
3   HAZARDS IDENTIFICATION                                                                              water from a safe distance. Cylinders which have
Main Hazards           All cylinders are portable gas containers, and must be                           been exposed to excessive heat should be clearly
                       regarded as pressure vessels at all times. Nitrous                               identified and returned to supplier. CONTACT
                       oxide is non-flammable, but readily supports                                     THE NEAREST AFROX BRANCH.
                       combustion. Never permit oil, grease or other readily    Protective Clothing     Safety goggles, gloves and safety shoes should be
                       combustible substance to come into contact with high                             worn when handling cylinders.
                       concentrations of nitrous oxide.                         Environmental precautions. As the gas is heavier than air, pockets of nitrous
Adverse Health Effects. Nitrous oxide should not be used with any condition                             oxide-enriched air could occur. These could lead
                       where air is entrapped within the body, and where its                            to the fire spreading rapidly. If possible, ventilate
                       expansion might be dangerous such as : Head                                      the affected area.
                       injuries with impairment of consciousness; Artificial,
                                                                                6    ACCIDENTAL RELEASE MEASURES
                       traumatic or spontaneous pneumothorax air
                       embolism; Decompression sickness; Following a            Personal Precautions   Although nitrous oxide is not itself combustible, it
                       recent dive; Following air encephelography; Severe                              supports and accelerates combustion. Clothes and
                       bullous emphysema; During myringoplasty; Gross                                  other materials, not normally considered
                       abdominal distension; Intoxication; Maxillofacial                               flammable, will burn fiercely in the presence of
                       injuries.                                                                       nitrous oxide, and can be set alight by a single
Chemical Hazards       Nitrous oxide is non-flammable, but strongly                                    spark, or even hot cigarette ash.
                       supports combustion (including some materials            Environmental precautions. Nitrous oxide is known to have an ozone
                       which do not normally burn in air). Since dry nitrous                            depleting potential. It is a "greenhouse gas" and
                       oxide is non-corrosive, most materials of                                        may contribute to global warming. Beware of
                       construction are suitable. Avoid all combustible                                 nitrous oxide-enriched atmospheres coming into
                       materials.                                                                       contact with readily combustible materials.
Biological Hazards     Administration of nitrous oxide, more frequently         Small spills            Shut off the source of escaping nitrous oxide.
                       than every 4 days should be accompanied by routine                               Ventilate the area.
                       blood cell counts for evidence of megaloblastic          Large spills            Evacuate the area. Shut off the source of the spill
                       change in red cells and hypersegmentation of                                     if this can be done without risk. Ventilate the area
                       neutrophils                                                                      using forced-draughtt if necessary.
Vapour Inhalation      The use of nitrous oxide causes inactivation of
                       vitamin B12 which is a co-factor of methionine           7    HANDLING AND STORAGE
                       synthase.      Folate metabolism is consequently         Do not allow cylinders to slide or come into contact with sharp edges.
                       interfered with, and DNA synthesis is impaired           Cylinders of nitrous oxide should not be stored near cylinders of acetylene or
                       following prolonged nitrous oxide administration.        other combustible gases. Nitrous oxide cylinders should only be stacked
                       These disturbances result in megaloblastic bone          vertically and be firmly secured. Prevent dirt, grit of any sort, oil or any other
                       marrow changes. Exceptionally heavy occupational         lubricant from entering the cylinder valves, and store cylinders well clear of
                       exposure and addiction have resulted in                  any corrosive influence, e.g. battery acid. Compliance with all relevant
                       myeloneuropathy        and     subacute      combined    legislation is essential. Use a "first in - first out" inventory system to prevent
                       degeneration.                                            full cylinders from being stored for excessive periods of time. Keep out of
Eye Contact            No known effect.                                         reach of children.
Skin Contact           No known effect.
                                                                                  13   DISPOSAL CONSIDERATIONS
8    EXPOSURE CONTROLS/PERSONAL PROTECTION                                        Disposal Methods            Small amounts may be blown to the atmosphere
                                                                                                              under controlled conditions.       Large amounts
Occupational Exposure Hazards. Scavenging of waste nitrous oxide gas
                                                                                                              should only be handled by the gas supplier.
                         should be used to reduce operating theatre and
                         equivalent treatment room levels to a level below        Disposal of packaging       The disposal of cylinders must only be handled by
                         200vpm of ambient nitrous oxide.                                                     the gas supplier.
Engineering control measures. Engineering control measures are preferred to
                        reduce exposure to nitrous oxide-enriched                 14   TRANSPORT INFORMATION
                        atmospheres. General methods include forced-              ROAD TRANSPORTATION
                        draught ventilation, separate from other exhaust          UN No.                                1070
                        ventilation systems. Ensure that sufficient fresh air     ERG No                                122
                        enters at, or near, floor level.                          Hazchem warning                       5A Non-flammable gas
Personal protection      Safety goggles, gloves and shoes should be worn          SEA TRANSPORTATION
                         when handling cylinders.                                 IMDG                                  1070
Skin                     No known effect.                                         Label                                 Non-flammable gas
                                                                                  AIR TRANSPORTATION
9    PHYSICAL AND CHEMICAL PROPERTIES
                                                                                  ICAO/IATA Code                        1070
PHYSICAL DATA                                                                     Class                                 2.2
Chemical Symbol                                     N2 O                          Packaging group
Molecular Weight                                    44,01                         Packaging instructions
Specific Volume @ 20°C & 101,325 kPa                543,1 ml/g                    -    Cargo                            200
Boiling point @ 101,325 kPa                         -88,5°C                       -    Passenger                        200
Density, gas @ 101,325 kPa and 20°C                 1,8432 kg/m3                  Maximum quantity allowed
Relative density (Air = 1) @ 101,325 kPa            1,5297                        -    Cargo                            150kg
Colour                                              None                          -    Passenger                        75kg
Taste                                               Sweet
Odour                                               Sweet                         15   REGULATORY INFORMATION
                                                                                  EEC Hazard class         Non-flammable
10   STABILITY AND REACTIVITY
                                                                                  Risk phrases             R8 Contact with combustible material may cause
Conditions to avoid      The build up of nitrous oxide-enriched                                            fire
                         atmospheres. Never use cylinders as rollers or                                    R20 Harmful by inhalation
                         supports, or for any other purpose than the storage                               R33 Danger of cumulative effects
                         of Nitrous oxide. Never expose cylinders to                                       R44 Risk of explosion if heated under
                         excessive heat, as this may cause sufficient build-                               confinement
                         up of pressure to rupture the cylinders.                                          R48 Danger of serious damage to health by
Incompatible Materials. Since dry nitrous oxide is non-corrosive, most                                     prolonged exposure.
                         materials of construction are suitable. Avoid all        Safety phrases           S2 Keep out of reach of children
                         flammable materials.                                                              S3 Keep in a cool place
Hazardous Decomposition Products. When involved in a fire the higher                                       S9 Keep container in a well-ventilated place
                         oxides of nitrogen can be formed. Both nitric                                     S21 When using do not smoke
                         oxide and nitrogen dioxide are highly toxic.                                      S44 If you feel unwell, seek medical advice (show
                                                                                                           the label where possible)
11   TOXICOLOGICAL INFORMATION                                                    National Legislation:    None
Acute Toxicity                See section 3                                       Refer to SABS 0265 for explanation of the above.
Skin & eye contact            No known effect.                                    16   OTHER INFORMATION
Chronic Toxicity              See section 3
Carcinogenicity               No known effect.                                    Bibliography
Mutagenicity                  No known effect.                                    Compressed Gas Association, Arlington, Virginia
Reproductive Hazards          See section 3                                       Handbook of Compressed Gases - 3rd Edition
(For further information see Section 3. Adverse Health Effects).                  Matheson. Matheson Gas Data Book - 6th Edition

12   ECOLOGICAL INFORMATION                                                       17   EXCLUSION OF LIABILITY
Nitrous oxide is heavier than air and care should be taken to avoid the           Information contained in this publication is accurate at the date of publication.
formation of nitrous oxide-enriched pockets. It does not pose a hazard to the     The company does not accept liability arising from the use of this information,
ecology.                                                                          or the use, application, adaptation or process of any products described herein.




AB                                                          A member of The AFROX Group
                                             The Stripe Symbol and the word AFROX are AFROX Group Trademarks.
                                                          For product and safety enquiries please phone
                                                          EMERGENCY N°: 0860020202 (24 hr)

								
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