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					American Heart of Poland, Ltd
Animal Cath Lab
ul. Medykow 4
40-006 Katowice
tel: +48 609-109-131

Headquarter:
American Heart of Poland, LLC
43-450 Ustroń, ul. Sanatoryjna 7
tel./fax +48 (033) 854-58-57,
+48 (033) 854-58-59




                                   American Heart of Poland, Ltd
                                   www.klinikiserca.pl
  AHP: the main goals

Providing patients with modern medical services in the field
of invasive cardiology require continuous education and
scientific research. Therefore we put a stress on clinical and
preclinical investigations. In accordance with this conviction
Clinical Research Organization and Animal Catheterization
Laboratory were created within structure of AHP.




     Pig

                                           American Heart of Poland, Ltd
                                           www.klinikiserca.pl
   AHP, Animal Cath Lab




So far, it is the only center in Poland and Central/East Europe. Scientific
activity conducted by experienced staff results in development of new
methods for treatment of CV diseases and fast introduction of new medical
technologies to clinical practice. Those efforts are being accomplished in
cooperation with European/USA industry and heart centers.




                                                  American Heart of Poland, Ltd
                                                  www.klinikiserca.pl
AHP, Animal Cath Lab


                         Rat




              Pig


Rabbit



                       American Heart of Poland, Ltd
                       www.klinikiserca.pl
American Heart of Poland, Ltd

Equipment:

1. Full profile operating suite
2. Mobile OEC angiograf, type 9600 Cardiac
3. Mobile table for radiological procedures
4. Galaxy 2, IVUS imaging system
5. Dash 2000 cardio-monitor
6. Respirator and defibrillator
7. Pressure injector
8. “QCA-CMS” Medis software
9. Motic camera with software for histomorphometry
10. Olympus microscope

                                    American Heart of Poland, Ltd
                                    www.klinikiserca.pl
American Heart of Poland, Ltd

We have possibility to house:

1.   Pigs
2.   Rams
3.   Goats
4.   Calves
5.   Seven variations of mice
6.   Four variations of rats
7.   Two variations of rabits
8.   Hamsters
9.   Guinea pigs- white and colour

                                     American Heart of Poland, Ltd
                                     www.klinikiserca.pl
   American Heart of Poland, Ltd
Experience:

All procedures are performed by experienced interventional
cardiologists with cooperation with vet doctors and
anasthesiolosits.
We develped the programm of animal model of in-stent
restenosis 3 years ago.
Our offer includes:
-stent implantation to pig coronary arteries with 4 week to 3
months follow-up
-stent cutting and resin embedding
-histopatholgical analysis
-IVUS/QCA analysis of angiograms
                                           American Heart of Poland, Ltd
                                           www.klinikiserca.pl
   American Heart of Poland, Ltd

Histopathology

All arteries with stents are fixed in formalin, dehydrated and
embedded in resin (glycol metacrylate). Stents are cut into
slices of 10 µm thickness with the use of Leica microtome
equipped with carbide-tipped knives. Obtained specimens are
stained with hematoxillin-eosin and are subsequently
undergoing histopathological analysis. Qualitative and
quantitative assessment is performed by an histopathologist,
who works in Upper-Silesian Medical School for 15 years and
is experienced in the field of histopathology.

                                          American Heart of Poland, Ltd
                                          www.klinikiserca.pl
   American Heart of Poland, Ltd

List of abstracts presented at international congresses
  and meetings:

1. Cobalt-chromium stents in porcine coronary arteries:
   angiographic and ultrasonographic outcomes
ESC Congress 2005, Stockholm
2. Biodegradable Polymer-Coated, Paclitaxel-Eluting
   Stents in the Porcine Coronary Arteries
TCT 2006, Washington
3. Biodegradable Polymer-Coated, Paclitaxel-Eluting
   Stents in the Porcine Coronary Arteries
12th International LDDR meeting, Geneva 2006
                                          American Heart of Poland, Ltd
                                          www.klinikiserca.pl
American Heart of Poland, Ltd
       PRIZES:




                          American Heart of Poland, Ltd
                          www.klinikiserca.pl
American Heart of Poland, Ltd




                                 Examples
                                 of histopathology
                                 specimens




                          American Heart of Poland, Ltd
                          www.klinikiserca.pl
American Heart of Poland, Ltd




                          Examples
                          of histopathology
                          specimens




                          American Heart of Poland, Ltd
                          www.klinikiserca.pl
 Current projects

• Evaluation of new DES with multiple drugs
delivery from one stent
• Development of the pig model of AMI and
chronic heart failure
• Mice model of AMI
• Prevention of reperfusion injury after
primary PCI in AMI
• Intra pericardial treatment
     •To prevent restenosis
     •To promote myocardial regeneration and angiogenesis


                                        American Heart of Poland, Ltd
                                        www.klinikiserca.pl
American Heart of Poland, Ltd

Useful addresses:

Katowice International Airport in Pyrzowice:
      www.gtl.com.pl/eng/index.html
      - about 35km from our cath-lab

Krakow International Airport in Balice:
      http://www.lotnisko-balice.pl/eng/
      - about 70km from our cath-lab




                                       American Heart of Poland, Ltd
                                       www.klinikiserca.pl
American Heart of Poland, Ltd

Below, you can also find some useful information concerning
   our activity.

• With which QCA software do you work?
• “QCA-CMS” Medis

• Do you have access to minipigs?
• Yes, we have possibilities to import minipigs on demand

• How time consuming is an animal trial approval?
• Usually we need 4-6 weeks for ethics committee approval.

• We need 2-3 month appointment to prepare the animal study
  and to book the cath lab time.

                                              American Heart of Poland, Ltd
                                              www.klinikiserca.pl

				
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