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Gut Bug Indications Gastointestinal Parasites Blastocystis Hominis Amoebic/bacterial parasites Amoebic dysentery Bacillary dysentery Ingredients Radix Sophorae Flavescentis (Ku Shen) Endothelium Corneum Gigeriae Galli (Ji Nei Jin) Caulis Sargento Doxae (Hong Teng) Radix Stemonae (Zhi Bai Bu) Semen Arecae Catechu (Bing Lang) Fructus Quisqualis (Shi Jun Zi) Radix Glycirrhizae (Gan Cao) Sclerotium Poriae (Fu Ling) Pericarpium Citri Reticulatae (Chen Pi) Rhizoma Dioscoreae Oppositae (Shan Yao) Testa Dolichoris (Bian Dou) Rhizoma Atractylodis Macrocephalae (Bai Zhu) Radix Saussureae Lappae (Mu Xiang) Contents 100X500mg capsules Dosage 3 caps before bed and first thing in the morning on an empty stomach, until parasites are eliminated; 2 - 4 weeks. Reduce dosage after 1 week or when symptoms are dimished. Symptoms abdominal cramps abdominal tenderness vomiting diarhhoea, 3 to 8 semiformed stools per day with mucus and occasionally blood frequent stools with bloody mucus liquid stools with streaks of blood painful bowel movements intestinal gas (excessive flatus/gas) fatigue fever mild fever weight loss Action Kills parasites. TCM Action Clears Heat Removes Damp Regulates qi Kills parasites Contraindications Pregnancy. Research Ku Shen/Radix Sophorae Flavescentis 1. Stomach-strengthening effect Gastrogavage of carbinol extract of ku shen and its ingredients could improve the small intestinal propulsive function in mice, and prevent the acute gastric membrane injury induced by hydrochloric acid-ethanol in rats. 2. Acute bacillary dysentery Oral administration of water decoction of ku shen was used to treat 45 cases of acute bacillary dysentery, after 5~7 days, 35 were cured and 7 improved. 3. Chronic non-specific colitis 30g ku shen was decocted to 80~100ml juice which was used for retention enema each night, 10 times as a course of treatment. 22 cases of chronic non-specific colitis were treated, 15 were relieved within a short term, 8 improved and 1 ineffective. 4. Giardia lamblia Oral administration of tablets or syrup made from ku shen extracturm. The dosage for adults was 30g crude drug daily, taken in three times. Decrease the dosage in children. 7 days consecutive administration as a course of treatment. 100 cases of Giardia lamblia were treated, and 92 were cured. Ji Nei Jin/Endothelium Corneum Gigeriae Galli 1. Effects on the digestive system Ji Nei Jin could increase the secretions of gastric juice, acidity and digestive function. 2. Duodenal ulcer wu zei gu, ji nei jin, bai ji, zhi shi, sheng gan cao 100g; yan hu 50g; chen pi 10g. All drugs were grounded into powder. 3~6g, tid. The method could be used to treat duodenal ulcer. Hong Teng/Caulis Sargento Doxae 1. Acute appendicitis Hong Teng was used as the main drug, accompanied with other Heat-clearing, Toxin-removing, Blood-activating and Blood stasis-removing drugs to treat acute appendicitis, and the therapeutic effect was good. 2. Parasites hong teng 30g and yellow wine 120g were decocted into 60ml which was used as one dose. 1 dose bid for adults, modify the dosage properly for children. The method was used to treat 5 cases of biliary ascariasis. After 1~4 days, abdominal pain disappeared, and 4 cases had bellyworm passed out. Besides, water decoction of hong teng, gou teng, qian niu hua and feng cha jue 9 g each could be used to treat hookworm diseases. Zhi Bai Bu/Radix Stemonae Anti Parasitic, kills Pinworms. Bing Lang/Semen Arecae Catechu Anthelminthic action Arecaline was the active ingredient in anthelminthic action. It had effects on pork tapeworm, taenia saginata, ascaris and threadworm. Shi Jun Zi/Fructus Quisqualis Helminthic action In vitro tests showed that shi jun zi had quite strong helminthic action on ascarides. Gan Cao/Radix Glycirrhizae 1. Anti ulcer action Significant inhibition on experimental ulcers in albino rats, produced by litigation of the pylorus, was obtained from subcutaneous injection or intraduodenal administration of the herb extract at the dose of 250mg/kg. Marked reductions of gastric juice and free acid and total acidity were observed 4 hours after pyloric litigation. Recent studies indicated that cAMP and cGMP could regulate gastric acid secretion and maintain the dynamic equilibrium of gastric acid. Glycyrrhetinic acid intragastrically given at the dose of 300mg/kg to rats did not affect adenyl cyclase of the gastric mucosa but could inhibit phosphodiesterase activity, thereby increasing cAMP level of the mucosae of the pylorus and cardia, and suppressing gastric acid secretion. It has also been shown that the water extract of Glycyrrhiza can inhibit the secretion of gastric juice and the formation of ulcers in the front stomach of rats, after ligation of the polyrus. It prevented gastric ulcers from forming. 2. Duodenal bulbar ulcer bai shao 25g; gan cao, hou po, chen pi, cang zhu, mu xiang, bai ji, yuan hu, 15g each; sha ren, bai zhu 10g; huang lian, wu zhu yu, 5g each. Modify the formula according to accompanied symptoms, 1 dose every day. 35 cases of duodenal bulbar ulcer were treated with this formula and all were effective. Fu Ling/Sclerotium Poriae 1. Effect on the Digestive System P. cocos has a direct stimulant effect on the isolated rabbit intestine1, inhibiting gastric ulcer, decreasing gastric secretion and free acidity1. 1. Tomizawa S. The Journal of Society for Oriental Medicine in Japan 1962 13(1): 5. 2. Infantile diarrhoea Fine fu ling powder 0.5~1g, tid was used to treat 98 cases of infantile autumn diarrhoea. Results: 79 cases were cured, 8 improved and 6 ineffective. 3. Chronic gastritis 82 cases of chronic gastritis were treated fu ling 30g, dang shen 15g, shan yao 15g, bai zhu 15g and gan cao 6g. The formula had significant effect on patients of Spleen Stomach deficiency type. Chen Pi/Pericarpium Citri Reticulatae 1. Actions on the Gastrointestinal Smooth Muscles The herb decoction inhibited the motility of the isolated small intestines of mice and rabbits; the intravenous injection of the decoction demonstrated an inhibitory effect on the gastrointestinal musculature of anesthetized dogs, small intestine of anesthetized rabbits, and stomach of anaesthetized rabbits. The action was weaker than that of epinephrine but more prolonged. This was probably due to the relative stability of the active component of the herb1. In experiments on the isolated rabbit intestine, various kinds of Chinese medicines including this herb, which are reputed to "regulate the vital energy", antagonized the effect of acetylcholine. But the inhibitory action of the herb on the isolated rabbit intestine was antagonized by acetylcholine. The herb could elicit further relaxation of the intestines if the intestinal muscular tone was already reduced by pretreatment with atropine2. The herb also antagonized intestinal spastic contraction due to pilocarpine or barium chlorite. All these results suggest that the mode of action mainly involves direct inhibition of the intestinal smooth muscles3. Hesperitin had a biphasic action on the isolated intestinal muscles, i.e., an initial transient stimulant action followed by inhibition4. In conclusion, the various actions of the herb on the digestive tract are not only due to its various constituents, but also subject to the functional states of the digestive tract itself. Hence, it exhibits aromatic, stomachic, carminative and antiflatulent actions, and relieves stagnation of vital energy in the "spleen" and stomach5. 2. Antigastric Ulcer Action Ligating the pylorus of the animals produced experimental rat models of gastric ulcer. Medication was given before and during the experiments. The results were as follows: daily subcutaneous injection of methylhesperitin at 100 mg/kg for 6 days markedly reduced the incidence of ulcers. It also inhibited gastric secretion. The anti-ulcer action was greatly enhanced when this agent was used concomitantly with vitamin C and vitamin K46. 3. Dyspepsia In cases of abdominal distention, tightness of the chest, anorexia, nausea and vomiting, the herb may be used "to regulate the vital energy" and stimulate the appetite. With more severe abdominal distention and pain, the herb may be used together with the rhizome of Atractylodes lancea and the bark and root bark of Magnolia officinalis. When vomiting and hiccups are prominent, the herb is usually combined with Phyllostachys nigra and the root of Codonopsis pilosula7. 1. Yokotani. Folia Pharmacologica Japonica 1960 56(6):1396. 2. Acute Abdomen Research Unit, Zunyi Medical College. Xinyiyaoxue Zazhi (Journal of Traditional Chinese Medicine) 1974 (12):39. 3. Zhongshan Medical College et al. Pharmacology. People's Medical Publishing House. 1979. p. 478. 4. Baraboi VA. Chemical Abstracts 1969 71:1957v. 5. Wang JM. Shanghai Zhongyiyao Zazhi (Shanghai Journal of Traditional Chinese Medicine) 1957 (9):44. 6. Heng GS. Polia Pharmacologica Japonica 1970 56(6):1373. 7. "Clinical Application of Chinese Traditional Drugs". New Chinese Medicine 1972 (6):43. Shan Yao/Rhizoma Dioscoreae oppositae Infantile diarrhoea Shan Zhu Tang: shan yao 9g; shan zhu yu, huang qin, ying su ke, 3g each; long yan rou, ge gen, che qian zi, 4g each. Modify the formula according to TCM differentiation. 892 cases of infantile diarrhoea were treated; all were effective except 16 cases. Bian Dou/Testa Dolichoris Chronic diarrhoea Jian Pi Hua Shi Tang: bu gu zhi, dang shen, shan yao, 15g each; bian dou 12g; fu ling 20g; bai zhu, huo xiang, bai dou kou, bu zha ye, 9g; chen pi, zhi gan cao, rou gui, 6g each. 1 dose each day, 4 weeks as a course of treatment. 52 out of 54 treated cases were effective. Bai Zhu/Rhizoma Atractylodis Macrocephalae 1. Chronic gastritis Yi Qi Hua Yu Tang was used as the main formula: dang shen, bai zhu, wu yao, fu ling, tian hua fen, chao mai ya, 12g each; chao shan yao, 20g, chuan lian zi, 10g, bai shao, dan shen, 15g each; ji nei jin, (ground into powder and taken with water), tao ren, 6g each; san qi (ground into powder and taken with water), 3g. 1 dose every day, water decoction. 75 out of the 82 treated cases were effective. 2. Non-specific colitis Jie Chang Ling (experiential formula): chai hu, bai zhu, bai shao, chen pi, fang feng, zhi shi, huang bo, ku shen, 9g each; mu xiang, wu mei, 6g each; gan cao, 3g, modify the formula according to TCM differentiation. 1 dose every day, water decoction. Enema mixture was also applied. 4 weeks as a course of treatment. 88 cases were treated, 84 cases were effective. Among 80 cases taking the reexamination of enteroscope, congestion, edema and erosion disappeared in 68 cases, improved in 12 cases. Mu Xiang/Radix Saussureae lappae 1. Effects on digestive system Decoction of mu xiang could decrease the gastric emptying time from 142.4¡À5.6 minutes to 83¡À14.8 minutes. The plasma gastrin was significantly increased 30 minutes after administration of mu xiang decoction. These indicated that mu xiang had gastric emptying improving effect. Decoction of mu xiang could increase intestinal peristalsis in vivo of rabbits, the contraction range and frequency of intestinal muscle increased too. Volatile oil had inhibitory effect on isolated intestines of rabbit, it could decrease the frequency and range, and the contraction became irregular too. 2. Flexure syndrome Xing Qi Zheng Chang Tang: mu xiang, hou po, da fu pi, bing lang pian, lai fu zi, zhi ke, 30g each; cheng xiang 15g. 1 dose every day, 2 weeks as a course of treatment. 200 cases were treated for 2 courses, 145 were cured, 52 improved and 3 ineffective. 3. Adhesive ileus Mu xiang, zhi ke, chi shao, yuan hu, chuan lian zi, yu li ren, sheng da huang (decocted later), mang xiao 5g each; hou po, huang bo, chao lai fu zi, gan cao 3g each; dang gui 6g; gua lou 10g. 1 dose every day, administrated through stomach tube. 33 cases were treated, and 30 were cured.
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