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Gut Bug

VIEWS: 19 PAGES: 3

									Gut Bug

Indications
Gastointestinal Parasites
Blastocystis Hominis
Amoebic/bacterial parasites
Amoebic dysentery
Bacillary dysentery

Ingredients
Radix Sophorae Flavescentis (Ku Shen)
Endothelium Corneum Gigeriae Galli (Ji Nei Jin)
Caulis Sargento Doxae (Hong Teng)
Radix Stemonae (Zhi Bai Bu)
Semen Arecae Catechu (Bing Lang)
Fructus Quisqualis (Shi Jun Zi)
Radix Glycirrhizae (Gan Cao)
Sclerotium Poriae (Fu Ling)
Pericarpium Citri Reticulatae (Chen Pi)
Rhizoma Dioscoreae Oppositae (Shan Yao)
Testa Dolichoris (Bian Dou)
Rhizoma Atractylodis Macrocephalae (Bai Zhu)
Radix Saussureae Lappae (Mu Xiang)

Contents
100X500mg capsules

Dosage
3 caps before bed and first thing in the morning on an empty stomach, until parasites are eliminated; 2 - 4 weeks.
Reduce dosage after 1 week or when symptoms are dimished.

Symptoms
abdominal cramps
abdominal tenderness
vomiting
diarhhoea, 3 to 8 semiformed stools per day with mucus and occasionally blood
frequent stools with bloody mucus
liquid stools with streaks of blood
painful bowel movements
intestinal gas (excessive flatus/gas)
fatigue
fever
mild fever
weight loss

Action
Kills parasites.

TCM Action
Clears Heat
Removes Damp
Regulates qi
Kills parasites

Contraindications
Pregnancy.

Research
Ku Shen/Radix Sophorae Flavescentis
1. Stomach-strengthening effect
Gastrogavage of carbinol extract of ku shen and its ingredients could improve the small intestinal propulsive function in
mice, and prevent the acute gastric membrane injury induced by hydrochloric acid-ethanol in rats.
2. Acute bacillary dysentery
Oral administration of water decoction of ku shen was used to treat 45 cases of acute bacillary dysentery, after 5~7
days, 35 were cured and 7 improved.
3. Chronic non-specific colitis
30g ku shen was decocted to 80~100ml juice which was used for retention enema each night, 10 times as a course of
treatment. 22 cases of chronic non-specific colitis were treated, 15 were relieved within a short term, 8 improved and 1
ineffective.
4. Giardia lamblia
Oral administration of tablets or syrup made from ku shen extracturm. The dosage for adults was 30g crude drug daily,
taken in three times. Decrease the dosage in children. 7 days consecutive administration as a course of treatment. 100
cases of Giardia lamblia were treated, and 92 were cured.
Ji Nei Jin/Endothelium Corneum Gigeriae Galli
1. Effects on the digestive system
Ji Nei Jin could increase the secretions of gastric juice, acidity and digestive function.
2. Duodenal ulcer
wu zei gu, ji nei jin, bai ji, zhi shi, sheng gan cao 100g; yan hu 50g; chen pi 10g. All drugs were grounded into powder.
3~6g, tid. The method could be used to treat duodenal ulcer.
Hong Teng/Caulis Sargento Doxae
1. Acute appendicitis
Hong Teng was used as the main drug, accompanied with other Heat-clearing, Toxin-removing, Blood-activating and
Blood stasis-removing drugs to treat acute appendicitis, and the therapeutic effect was good.
2. Parasites
hong teng 30g and yellow wine 120g were decocted into 60ml which was used as one dose. 1 dose bid for adults,
modify the dosage properly for children. The method was used to treat 5 cases of biliary ascariasis. After 1~4 days,
abdominal pain disappeared, and 4 cases had bellyworm passed out. Besides, water decoction of hong teng, gou teng,
qian niu hua and feng cha jue 9 g each could be used to treat hookworm diseases.
Zhi Bai Bu/Radix Stemonae
Anti Parasitic, kills Pinworms.
Bing Lang/Semen Arecae Catechu
Anthelminthic action
Arecaline was the active ingredient in anthelminthic action. It had effects on pork tapeworm, taenia saginata, ascaris
and threadworm.
Shi Jun Zi/Fructus Quisqualis
Helminthic action
In vitro tests showed that shi jun zi had quite strong helminthic action on ascarides.
Gan Cao/Radix Glycirrhizae
1. Anti ulcer action
Significant inhibition on experimental ulcers in albino rats, produced by litigation of the pylorus, was obtained from
subcutaneous injection or intraduodenal administration of the herb extract at the dose of 250mg/kg. Marked reductions
of gastric juice and free acid and total acidity were observed 4 hours after pyloric litigation. Recent studies indicated
that cAMP and cGMP could regulate gastric acid secretion and maintain the dynamic equilibrium of gastric acid.
Glycyrrhetinic acid intragastrically given at the dose of 300mg/kg to rats did not affect adenyl cyclase of the gastric
mucosa but could inhibit phosphodiesterase activity, thereby increasing cAMP level of the mucosae of the pylorus and
cardia, and suppressing gastric acid secretion. It has also been shown that the water extract of Glycyrrhiza can inhibit
the secretion of gastric juice and the formation of ulcers in the front stomach of rats, after ligation of the polyrus. It
prevented gastric ulcers from forming.
2. Duodenal bulbar ulcer
bai shao 25g; gan cao, hou po, chen pi, cang zhu, mu xiang, bai ji, yuan hu, 15g each; sha ren, bai zhu 10g; huang
lian, wu zhu yu, 5g each. Modify the formula according to accompanied symptoms, 1 dose every day. 35 cases of
duodenal bulbar ulcer were treated with this formula and all were effective.
Fu Ling/Sclerotium Poriae
1. Effect on the Digestive System
P. cocos has a direct stimulant effect on the isolated rabbit intestine1, inhibiting gastric ulcer, decreasing gastric
secretion and free acidity1.
1. Tomizawa S. The Journal of Society for Oriental Medicine in Japan 1962 13(1): 5.
2. Infantile diarrhoea
Fine fu ling powder 0.5~1g, tid was used to treat 98 cases of infantile autumn diarrhoea. Results: 79 cases were cured,
8 improved and 6 ineffective.
3. Chronic gastritis
82 cases of chronic gastritis were treated fu ling 30g, dang shen 15g, shan yao 15g, bai zhu 15g and gan cao 6g. The
formula had significant effect on patients of Spleen Stomach deficiency type.
Chen Pi/Pericarpium Citri Reticulatae
1. Actions on the Gastrointestinal Smooth Muscles
The herb decoction inhibited the motility of the isolated small intestines of mice and rabbits; the intravenous injection
of the decoction demonstrated an inhibitory effect on the gastrointestinal musculature of anesthetized dogs, small
intestine of anesthetized rabbits, and stomach of anaesthetized rabbits. The action was weaker than that of epinephrine
but more prolonged. This was probably due to the relative stability of the active component of the herb1. In
experiments on the isolated rabbit intestine, various kinds of Chinese medicines including this herb, which are reputed
to "regulate the vital energy", antagonized the effect of acetylcholine. But the inhibitory action of the herb on the
isolated rabbit intestine was antagonized by acetylcholine. The herb could elicit further relaxation of the intestines if the
intestinal muscular tone was already reduced by pretreatment with atropine2.
The herb also antagonized intestinal spastic contraction due to pilocarpine or barium chlorite. All these results suggest
that the mode of action mainly involves direct inhibition of the intestinal smooth muscles3.
Hesperitin had a biphasic action on the isolated intestinal muscles, i.e., an initial transient stimulant action followed by
inhibition4.
In conclusion, the various actions of the herb on the digestive tract are not only due to its various constituents, but also
subject to the functional states of the digestive tract itself. Hence, it exhibits aromatic, stomachic, carminative and
antiflatulent actions, and relieves stagnation of vital energy in the "spleen" and stomach5.
2. Antigastric Ulcer Action
Ligating the pylorus of the animals produced experimental rat models of gastric ulcer. Medication was given before and
during the experiments. The results were as follows: daily subcutaneous injection of methylhesperitin at 100 mg/kg for
6 days markedly reduced the incidence of ulcers. It also inhibited gastric secretion. The anti-ulcer action was greatly
enhanced when this agent was used concomitantly with vitamin C and vitamin K46.
3. Dyspepsia
In cases of abdominal distention, tightness of the chest, anorexia, nausea and vomiting, the herb may be used "to
regulate the vital energy" and stimulate the appetite. With more severe abdominal distention and pain, the herb may
be used together with the rhizome of Atractylodes lancea and the bark and root bark of Magnolia officinalis. When
vomiting and hiccups are prominent, the herb is usually combined with Phyllostachys nigra and the root of Codonopsis
pilosula7.
1. Yokotani. Folia Pharmacologica Japonica 1960 56(6):1396.
2. Acute Abdomen Research Unit, Zunyi Medical College. Xinyiyaoxue Zazhi (Journal of Traditional Chinese Medicine)
1974 (12):39.
3. Zhongshan Medical College et al. Pharmacology. People's Medical Publishing House. 1979. p. 478.
4. Baraboi VA. Chemical Abstracts 1969 71:1957v.
5. Wang JM. Shanghai Zhongyiyao Zazhi (Shanghai Journal of Traditional Chinese Medicine) 1957 (9):44.
6. Heng GS. Polia Pharmacologica Japonica 1970 56(6):1373.
7. "Clinical Application of Chinese Traditional Drugs". New Chinese Medicine 1972 (6):43.
Shan Yao/Rhizoma Dioscoreae oppositae
Infantile diarrhoea
Shan Zhu Tang: shan yao 9g; shan zhu yu, huang qin, ying su ke, 3g each; long yan rou, ge gen, che qian zi, 4g each.
Modify the formula according to TCM differentiation. 892 cases of infantile diarrhoea were treated; all were effective
except 16 cases.
Bian Dou/Testa Dolichoris
Chronic diarrhoea
Jian Pi Hua Shi Tang: bu gu zhi, dang shen, shan yao, 15g each; bian dou 12g; fu ling 20g; bai zhu, huo xiang, bai dou
kou, bu zha ye, 9g; chen pi, zhi gan cao, rou gui, 6g each. 1 dose each day, 4 weeks as a course of treatment. 52 out
of 54 treated cases were effective.
Bai Zhu/Rhizoma Atractylodis Macrocephalae
1. Chronic gastritis
Yi Qi Hua Yu Tang was used as the main formula: dang shen, bai zhu, wu yao, fu ling, tian hua fen, chao mai ya, 12g
each; chao shan yao, 20g, chuan lian zi, 10g, bai shao, dan shen, 15g each; ji nei jin, (ground into powder and taken
with water), tao ren, 6g each; san qi (ground into powder and taken with water), 3g. 1 dose every day, water
decoction. 75 out of the 82 treated cases were effective.
2. Non-specific colitis
Jie Chang Ling (experiential formula): chai hu, bai zhu, bai shao, chen pi, fang feng, zhi shi, huang bo, ku shen, 9g
each; mu xiang, wu mei, 6g each; gan cao, 3g, modify the formula according to TCM differentiation. 1 dose every day,
water decoction. Enema mixture was also applied. 4 weeks as a course of treatment. 88 cases were treated, 84 cases
were effective. Among 80 cases taking the reexamination of enteroscope, congestion, edema and erosion disappeared
in 68 cases, improved in 12 cases.
Mu Xiang/Radix Saussureae lappae
1. Effects on digestive system
Decoction of mu xiang could decrease the gastric emptying time from 142.4¡À5.6 minutes to 83¡À14.8 minutes. The
plasma gastrin was significantly increased 30 minutes after administration of mu xiang decoction. These indicated that
mu xiang had gastric emptying improving effect. Decoction of mu xiang could increase intestinal peristalsis in vivo of
rabbits, the contraction range and frequency of intestinal muscle increased too. Volatile oil had inhibitory effect on
isolated intestines of rabbit, it could decrease the frequency and range, and the contraction became irregular too.
2. Flexure syndrome
Xing Qi Zheng Chang Tang: mu xiang, hou po, da fu pi, bing lang pian, lai fu zi, zhi ke, 30g each; cheng xiang 15g. 1
dose every day, 2 weeks as a course of treatment. 200 cases were treated for 2 courses, 145 were cured, 52 improved
and 3 ineffective.
3. Adhesive ileus
Mu xiang, zhi ke, chi shao, yuan hu, chuan lian zi, yu li ren, sheng da huang (decocted later), mang xiao 5g each; hou
po, huang bo, chao lai fu zi, gan cao 3g each; dang gui 6g; gua lou 10g. 1 dose every day, administrated through
stomach tube. 33 cases were treated, and 30 were cured.

								
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