Hospital Acquired Bacterial Infections Market to 2016 - Increasing Antibiotic Resistance and Increasing Population of Critically Ill Patients To Drive Growth by GBIResearch

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									           Hospital Acquired Bacterial Infections Market to 2016 -
               Increasing Antibiotic Resistance and Increasing
              Population of Critically Ill Patients To Drive Growth
     Reference Code: GBIHC060MR                                                                                  Publication Date: December 2010

                                       Global Hospital Acquired Bacterial Infections Market
                                       GBI Research has found that the global Hospital Acquired Bacterial Infections (HABI) market has
                                       been growing in the pharmaceutical industry. However, market growth is expected to slow down
                                       due to various restraints such as patent expiries of key drugs across all disease segments, the
                                       entry of generics, and the decreased annual cost of therapy in major markets such as the US,
                                       Japan and the top five countries in Europe (the UK, Spain, Italy, Germany and France).
                                       Nevertheless, the global HABI is a niche market which is expected to be very dynamic in the future.
                                       The Global Hospital Acquired Bacterial Infections Market is Forecast to Show Moderate
                                       Decline

   Global HABI market will             In 2009, the HABI market was estimated to be worth $1.8 billion, representing a Compound Annual
   be worth $ 1.4 billion by           Growth Rate (CAGR) of 1.6% between 2001 and 2009.
   2016                                The market is expected to decline to $1.4 billion by 2016, indicating a negative CAGR of 2.9%
                                       between 2009 and 2016. The primary reason for the decline is the patent expiries of major
                                       blockbusters, which are expected to decrease the annual cost of therapy after 2009.
                                       The global HABI market is expected to witness a series of patent expiries between 2009 and 2016,
                                       which includes most of the top selling blockbuster drugs in the Urinary Tract Infections (UTI),
                                       Pneumonia, Surgical Site Infections (SSI) and Blood Stream Infections (BSI) markets. The major
                                       drugs that are set to lose patent protection include Zyvox (linezolid, 2013), Levaquin (levofloxacin,
                                       2010), Invanz (ertapenem, 2013) and Tobi (tobramycin, 2014).
                                       Acquisitions Are the Major Deal Type in the Hospital Acquired Bacterial Infections (HABI)
                                       Market Because Major Pharmaceutical Companies Are Reluctant to Invest in Anti-Bacterial
                                       R&D

  Acquisitions accounted for            Hospital Acquired Bacterial Infections Market, Global, Major M&A Deals by Deal Type(%),
  74% of the total number of            2004–2010
  deals in HABI market
                                                                                         Merger
                                                                                          13%




                                                                  Asset Transactions
                                                                         13%




                                                                                                                      Acquisition
                                                                                                                        74%




                                        Source: GBI Research, Company websites



                                       The M&A deals landscape from 2004–2010 suggests that acquisitions are the major deal type
                                       accounting for 74% of the total, followed by asset-transactions and mergers accounting for 13%
                                       each. This signifies that companies are reluctant to invest in anti-bacterial R&D and they prefer to
                                       acquire companies which have developed a new molecule.



Hospital Acquired Bacterial Infections Market to 2016 -                                                            GBIHC060MR /Published DEC 2010
Increasing Antibiotic Resistance and Increasing Population of
Critically Ill Patients To Drive Growth                                                                                                         Page 1
                                                                                 © GBI Research. This is a licensed product and is not to be photocopied
                                       There is low or zero investment in R&D for anti-bacterials by large pharmaceutical companies
                                       because of the small life-cycle of anti-bacterials due to resistance developed against them. So the
                                       investment in R&D for anti-bacterials does not give a good return on investment.
                                       Pipeline Drugs by Phase of Development

                                        Hospital Acquired Bacterial Infections, Global, Pipeline by Phase (%), 2010

                                                                            Filed                   Phase I
                                                                            17%                      17%




                                                                                       Phase II
                                                                                        66%



                                        Source: GBI Research



                                       The percentage of molecules in the Phase II of development accounts for 66% to the total
                                       molecules in the pipeline. This is followed by Phase I and filed molecules which accounts for 17%
                                       each to the total pipeline molecules in the pipeline for HABI.




Hospital Acquired Bacterial Infections Market to 2016 -                                                       GBIHC060MR /Published DEC 2010
Increasing Antibiotic Resistance and Increasing Population of
Critically Ill Patients To Drive Growth                                                                                                 Page 2
                                                                         © GBI Research. This is a licensed product and is not to be photocopied
                                       1 Table of Contents
                                       1   Table of Contents ........................................................................................................................ 3
                                           1.1    List of Tables..................................................................................................................... 5
                                           1.2    List of Figures ................................................................................................................... 7
                                       2   Global Hospital Acquired Bacterial Infections Market: Introduction ........................................... 10
                                           2.1    GBI Research Report Guidance ..................................................................................... 10
                                       3   Global Hospital Acquired Bacterial Infections Market: Market Overview ................................... 11
                                           3.1    Introduction ..................................................................................................................... 11
                                           3.2    Revenue Forecasts for the Global Hospital Acquired Bacterial Infections Market .......... 12
                                              3.2.1    Sales Value ............................................................................................................. 12
                                              3.2.2    Annual Cost of Therapy........................................................................................... 13
                                              3.2.3    Treatment Usage Patterns ...................................................................................... 14
                                           3.3    Hospital Acquired Bacterial Infections Market Drivers .................................................... 18
                                              3.3.1    Steady Increase in Elderly and Immuno-Suppressed Population ............................ 18
                                              3.3.2    Increase in Average Number of Days Spent In Hospitals........................................ 18
                                              3.3.3    Patent Expiries of Branded Drugs Will Make Them More Affordable ...................... 18
                                           3.4    Hospital Acquired Bacterial Infections Market Restraints................................................ 18
                                              3.4.1    Increased Penetration of Generics Pose a Serious Threat for Primary Manufacturers
                                                        ................................................................................................................................ 18
                                              3.4.2    Increased Anti-bacterial Surveillance in Hospitals ................................................... 18
                                       4   Global Hospital Acquired Bacterial Infections Market: Therapeutic Landscape......................... 19
                                           4.1    Hospital Acquired Urinary Tract Infections (UTI) Market................................................. 19
                                              4.1.1    Introduction.............................................................................................................. 19
                                              4.1.2    Sales Value ............................................................................................................. 19
                                              4.1.3    Annual Cost of Therapy........................................................................................... 21
                                              4.1.4    Treatment Usage Patterns ...................................................................................... 22
                                              4.1.5    Market Share by Geography.................................................................................... 26
                                           4.2    Hospital Acquired Bacterial Pneumonia Market .............................................................. 28
                                              4.2.1    Introduction.............................................................................................................. 28
                                              4.2.2    Sales Value ............................................................................................................. 28
                                              4.2.3    Annual Cost of Therapy........................................................................................... 30
                                              4.2.4    Treatment Usage Patterns ...................................................................................... 31
                                              4.2.5    Market Share by Geography.................................................................................... 35
                                           4.3    Hospital Acquired Bacterial Surgical Site Infections Market............................................ 37
                                              4.3.1    Introduction.............................................................................................................. 37
                                              4.3.2    Sales Value ............................................................................................................. 37
                                              4.3.3    Annual Cost of Therapy........................................................................................... 38
                                              4.3.4    Treatment Usage Patterns ...................................................................................... 39
                                              4.3.5    Market Share by Geography.................................................................................... 43
                                           4.4    Hospital Acquired Bacterial Blood Stream Infections (BSI) Market ................................. 45
                                              4.4.1    Introduction.............................................................................................................. 45
                                              4.4.2    Sales Value ............................................................................................................. 45
                                              4.4.3    Annual Cost of Therapy........................................................................................... 46
                                              4.4.4    Treatment Usage Patterns ...................................................................................... 47
                                              4.4.5    Market Share by Geography.................................................................................... 51
                                       5   Global Hospital Acquired Bacterial Infections Market: Geographical Landscape ...................... 54
                                           5.1    Geographical Break-up ................................................................................................... 54
                                           5.2    The US............................................................................................................................ 56
                                              5.2.1    Sales Value ............................................................................................................. 56
                                              5.2.2    Annual Cost of Therapy........................................................................................... 57
                                              5.2.3    Treatment Usage Patterns ...................................................................................... 58
                                           5.3    Top Five Countries in Europe ......................................................................................... 62
                                              5.3.1    Sales Value ............................................................................................................. 62
                                              5.3.2    Annual Cost of Therapy........................................................................................... 63


Hospital Acquired Bacterial Infections Market to 2016 -                                                                                  GBIHC060MR /Published DEC 2010
Increasing Antibiotic Resistance and Increasing Population of
Critically Ill Patients To Drive Growth                                                                                                                                          Page 3
                                                                                          © GBI Research. This is a licensed product and is not to be photocopied
                                              5.3.3    Treatment Usage Patterns ...................................................................................... 64
                                           5.4    Japan .............................................................................................................................. 68
                                              5.4.1    Sales Value ............................................................................................................. 68
                                              5.4.2    Annual Cost of Therapy........................................................................................... 69
                                              5.4.3    Treatment Usage Patterns ...................................................................................... 70
                                       6   Global Hospital Acquired Bacterial Infections: Pipeline Analysis ............................................... 74
                                           6.1    Profiles of Key Late Stage Drugs .................................................................................... 74
                                              6.1.1    NVC-422.................................................................................................................. 74
                                              6.1.2    IC-43........................................................................................................................ 75
                                              6.1.3    Torizolid ................................................................................................................... 76
                                              6.1.4    KBPA-101................................................................................................................ 77
                                              6.1.5    hLF1-11 ................................................................................................................... 78
                                           6.2    Pipeline Drugs by Phase of Development....................................................................... 79
                                       7   Global Hospital Acquired Bacterial Infections Market: Competitive Landscape......................... 80
                                           7.1    Competitive Profiling ....................................................................................................... 80
                                              7.1.1    Johnson & Johnson (J&J)........................................................................................ 80
                                              7.1.2    Pfizer ....................................................................................................................... 81
                                              7.1.3    Cubist Pharmaceuticals ........................................................................................... 83
                                              7.1.4    Bayer ....................................................................................................................... 83
                                       8   Global Hospital Acquired Bacterial Infections Market: Strategic Consolidations........................ 85
                                           8.1    Overview ......................................................................................................................... 85
                                           8.2    M&A Deals by Geography............................................................................................... 85
                                           8.3    M&A Deals by Value ....................................................................................................... 85
                                           8.4    M&A Deals by Deal Type ................................................................................................ 86
                                              8.4.1    AstraZeneca Completed the Acquisition of Novexel SA in March 2010 .................. 87
                                              8.4.2    Pharma Omnium International Acquired Mutabilis in July 2009............................... 87
                                              8.4.3    Hilton Pharma Merges with Sami Pharmaceuticals in November 2008................... 87
                                              8.4.4    Phylogica Acquired Additional 63% Stake in Dynamic Microbials in November 2008
                                                        ................................................................................................................................ 87
                                              8.4.5    Sanofi Pasteur Acquired Acambis in September 2008 ............................................ 87
                                           8.5    R&D Licensing Agreements ............................................................................................ 88
                                              8.5.1    Major Licensing Agreements ................................................................................... 89
                                       9   Global Hospital Acquired Bacterial Infections Market: Appendix ............................................... 92
                                           9.1    Market Definitions ........................................................................................................... 92
                                           9.2    Abbreviations .................................................................................................................. 92
                                           9.3    Research Methodology ................................................................................................... 93
                                              9.3.1    Coverage ................................................................................................................. 93
                                              9.3.2    Secondary Research ............................................................................................... 93
                                              9.3.3    Primary Research.................................................................................................... 93
                                              9.3.4    Forecasts................................................................................................................. 94
                                              9.3.5    Expert Panel Validation ........................................................................................... 96
                                           9.4    Contact Us ...................................................................................................................... 97
                                           9.5    Disclaimer ....................................................................................................................... 97
                                           9.6    Sources........................................................................................................................... 97




Hospital Acquired Bacterial Infections Market to 2016 -                                                                                  GBIHC060MR /Published DEC 2010
Increasing Antibiotic Resistance and Increasing Population of
Critically Ill Patients To Drive Growth                                                                                                                                          Page 4
                                                                                          © GBI Research. This is a licensed product and is not to be photocopied
                                       1.1     List of Tables
                                       Table 1:    Hospital Acquired Bacterial Infections Market, Global, Sales Value ($m), 2001–2009 .. 12
                                       Table 2:    Hospital Acquired Bacterial Infections Market, Global, Sales Value ($m), 2009–2016 .. 12
                                       Table 3:    Hospital Acquired Bacterial Infections Market, Global, Annual Cost of Therapy ($),
                                                   2001–2009 ..................................................................................................................... 13
                                       Table 4:    Hospital Acquired Bacterial Infections Market, Global, Annual Cost of Therapy ($),
                                                   2009–2016 ..................................................................................................................... 13
                                       Table 5:    Hospital Acquired Bacterial Infections Market, Global, Treatment Usage Patterns
                                                   (million), 2001–2009....................................................................................................... 14
                                       Table 6:    Hospital Acquired Bacterial Infections Market, Global, Treatment Usage Patterns
                                                   (million), 2009–2016....................................................................................................... 14
                                       Table 7:    Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Sales Value ($m),
                                                   2001–2009 ..................................................................................................................... 20
                                       Table 8:    Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Sales Value ($m),
                                                   2009–2016 ..................................................................................................................... 20
                                       Table 9:    Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Annual Cost of
                                                   Therapy ($), 2001–2009................................................................................................. 21
                                       Table 10:   Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Annual Cost of
                                                   Therapy ($), 2009–2016................................................................................................. 21
                                       Table 11:   Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Treatment Usage
                                                   Patterns (million), 2001–2009 ........................................................................................ 22
                                       Table 12:   Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Treatment Usage
                                                   Patterns (million), 2009–2016 ........................................................................................ 22
                                       Table 13:   Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Geographical
                                                   Segmentation ($m), 2001–2009..................................................................................... 27
                                       Table 14:   Hospital Acquired Bacterial Urinary Tract Infections Market, Global, Geographical
                                                   Segmentation ($m), 2009–2016..................................................................................... 27
                                       Table 15:   Hospital Acquired Bacterial Pneumonia Market, Global, Sales Value ($m), 2001–2009 29
                                       Table 16:   Hospital Acquired Bacterial Pneumonia Market, Global, Sales Value ($m), 2009–2016 29
                                       Table 17:   Hospital Acquired Bacterial Pneumonia Market, Global, Annual Cost of Therapy ($),
                                                   2001–2009 ..................................................................................................................... 30
                                       Table 18:   Hospital Acquired Bacterial Pneumonia Market, Global, Annual Cost of Therapy ($),
                                                   2009–2016 ..................................................................................................................... 30
                                       Table 19:   Hospital Acquired Bacterial Pneumonia Market, Global, Treatment Usage Patterns
                                                   (thousand), 2001–2009 .................................................................................................. 31
                                       Table 20:   Hospital Acquired Bacterial Pneumonia Market, Global, Treatment Usage Patterns
                                                   (thousand), 2009–2016 .................................................................................................. 31
                                       Table 21:   Hospital Acquired Bacterial Pneumonia Market, Global, Geographical Segmentation
                                                   ($m), 2001–2009............................................................................................................ 36
                                       Table 22:   Hospital Acquired Bacterial Pneumonia Market, Global, Geographical Segmentation
                                                   ($m), 2009–2016............................................................................................................ 36
                                       Table 23:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Sales Value ($m),
                                                   2001–2009 ..................................................................................................................... 37
                                       Table 24:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Sales Value ($m),
                                                   2009–2016 ..................................................................................................................... 38
                                       Table 25:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Annual Cost of
                                                   Therapy ($), 2001–2009................................................................................................. 38
                                       Table 26:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Annual Cost of
                                                   Therapy ($), 2009–2016................................................................................................. 38
                                       Table 27:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Treatment Usage
                                                   Patterns (thousand), 2001–2009.................................................................................... 39
                                       Table 28:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Treatment Usage
                                                   Patterns (thousand), 2009–2016.................................................................................... 39
                                       Table 29:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Geographical
                                                   Segmentation ($m), 2001–2009..................................................................................... 44
                                       Table 30:   Hospital Acquired Bacterial Surgical Site Infections Market, Global, Geographical
                                                   Segmentation ($m), 2009–2016..................................................................................... 44
                                       Table 31:   Hospital Acquired Bacterial Bloodstream Infections Market, Global, Sales Value ($m),
                                                   2001–2009 ..................................................................................................................... 45
                                       Table 32:   Hospital Acquired Bacterial Bloodstream Infections Market, Global, Sales Value ($m),
                                                   2009–2016 ..................................................................................................................... 46


Hospital Acquired Bacterial Infections Market to 2016 -                                                                             GBIHC060MR /Published DEC 2010
Increasing Antibiotic Resistance and Increasing Population of
Critically Ill Patients To Drive Growth                                                                                                                                    Page 5
                                                                                      © GBI Research. This is a licensed product and is not to be photocopied
                                       Table 33: Hospital Acquired Bacterial Bloodstream Infections Market, Global, Annual Cost of
                                                 Therapy ($), 2001–2009................................................................................................. 46
                                       Table 34: Hospital Acquired Bacterial Bloodstream Infections Market, Global, Annual Cost of
                                                 Therapy ($), 2009–2016................................................................................................ 47
                                       Table 35: Hospital Acquired Bacterial Bloodstream Infections Market, Global, Treatment Usage
                                                 Patterns (thousand), 2001–2009.................................................................................... 47
                                       Table 36: Hospital Acquired Bacterial Bloodstream Infections Market, Global, Treatment Usage
                                                 Patterns (thousand), 2009–2016.................................................................................... 48
                                       Table 37: Hospital Acquired Bacterial Bloodstream Infections Market, Global, Geographical
                                                 Segmentation ($m), 2001–2009..................................................................................... 52
                                       Table 38: Hospital Acquired Bacterial Bloodstream Infections Market, Global, Geographical
                                                 Segmentation ($m), 2009–2016..................................................................................... 52
                                       Table 39: Hospital Acquired Bacterial Infections Market, Global, Sales Value by Geography ($m),
                                                 2001–2009 ..................................................................................................................... 55
                                       Table 40: Hospital Acquired Bacterial Infections Market, Global, Sales Value by Geography ($m),
                                                 2009–2016 ..................................................................................................................... 55
                                       Table 41: Hospital Acquired Bacterial Infections Market, The US, Sales Value ($m), 2001–2009. 56
                                       Table 42: Hospital Acquired Bacterial Infections Market, The US, Sales Value ($m), 2009–2016. 56
                                       Table 43: Hospital Acquired Bacterial Infections Market, The US, Annual Cost of Therapy ($),
                                                 2001–2009 ..................................................................................................................... 57
                                       Table 44: Hospital Acquired Bacterial Infections Market, The US, Annual Cost of Therapy ($),
                                                 2009–2016 ..................................................................................................................... 57
                                       Table 45: Hospital Acquired Bacterial Infections Market, The US, Treatment Usage Patterns
                                                 (million), 2001–2009....................................................................................................... 58
                                       Table 46: Hospital Acquired Bacterial Infections Market, The US, Treatment Usage Patterns
                                                 (million), 2009–2016....................................................................................................... 58
                                       Table 47: Hospital Acquired Bacterial Infections Market, Top Five Countries in Europe, Sales
                                                 Value ($m), 2001–2009.................................................................................................. 62
                                       Table 48: Hospital Acquired Bacterial Infections Market, Top Five Countries in Europe, Sales
                                                 Value ($m), 2009–2016.................................................................................................. 62
                                       Table 49: Hospital Acquired Bacterial Infections Market, Top Five Countries in Europe, Annual
                                                 Cost of Therapy ($), 2001–2009 .................................................................................... 63
                                       Table 50: Hospital Acquired Bacterial Infections Market, Top Five Countries in Europe, Annual
                                                 Cost of Therapy ($), 2009–2016 .................................................................................... 63
                                       Table 51: Hospital Acquired Bacterial Infections Market, Top Five Countries in Europe, Treatment
                                                 Usage Pattern (thousand), 2001–2009 .......................................................................... 64
                                       Table 52: Hospital Acquired Bacterial Infections Market, Top Five Countries in Europe, Treatment
                                                 Usage Pattern (thousand), 2009–2016 .......................................................................... 64
                                       Table 53: Hospital Acquired Bacterial Infections Market, Japan, Sales Value ($m), 2001–2009 ... 68
                                       Table 54: Hospital Acquired Bacterial Infections Market, Japan, Sales Value ($m), 2009–2016 ... 68
                                       Table 55: Hospital Acquired Bacterial Infections Market, Japan, Annual Cost of Therapy ($),
                                                 2001–2009 ..............................................................
								
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