Recognizing Lyme Disease by aihaozhe2


									In 2010, the presence of Lyme in the body no longer has to be a guessing game.

1975 was the first recognition of the condition in Lyme, CT. For those afflicted with
the symptoms, the problem of bringing Lyme disease to resolution has been to
accurately identify the disease. However, the history of the disease goes back to 1883
as you can see by the graph below provided by Brown University relying on
information provided in part by Douglas Dodge (See references below). Since the
formal recognition and naming of the disease, Lyme has spread and continues to do so
at an alarming rate.

Timeline of important events in the history of Lyme Disease

1883 - The first recorded case of Lyme Disease is described by Alfred Buchwald. He
described it as a degenerative skin disorder now known as ACA (acrodermatitis
chronica atorphicans).

1909 - Arvid Afzelius presents his research on expanding ring like lesion (erythema
migrans) associated with what would become known as Lyme Disease.

1921 - Arvid Afzelius publishes his work and speculates on the origin of the disease
as the Ixodes Scapularis tick and connects the disease with joint problems.

1922 - The disease is found to be associated with neurological problems.

1930 - The disease is found to also cause psychiatric problems.

1934 - Appearance of EM or ACA is associated with benign lymphocytomas. Arthritic
symptoms are reported in connection with the disease.

1970 - Rudolph Scrimenti, professor of dermatology publishes reports of the rash.

1975 - Allen C. Steere, Yale, investigates a group of rashes and swollen joints in Lyme,
Connecticut. Scrimenti publishes about his treatment of the rash with penicillin.

1976 - A clustering of cases of the disease is reported in a Naval Medical Hospital in

1977 - Steere et. Al misdiagnoses Lyme Disease as juvenile rheumatoid arthritis and
names the condition Lyme Arthritis.

1982 - The etiological agent of the disease, Borrelia burgdorferi, is discovered by Dr.
Willy Burgdorfer.

1983 - Treatment of Lyme disease with oral and intravenous antibiotics begins and
clinicians define the three stages of Lyme Disease.

1986 - Skeptics denounce the existence of Lyme Disease.

1988 - Lyme Disease Foundation (LDF) Founded.

1997 - Borrelia burgdorferi genome sequenced by TIGR.

1999 - Smith Kline Beecham receive FDA approval and place LYMErix vaccine on
the market.

2002 - LYMErix vaccine removed from market.

The first attempts in Lyme recognition were through blood tests. Unfortunately, a
large percentage of the results generated from this method were found to be

2010 - Of most recent importance is the following…

According to an article published March 30th, 2010 entitled Connecticut Pathologist
Debuts Lyme Disease Test Based on Nested PCR, DNA Sequencing, by Kirell
Lakhman, "A scientist in Connecticut has launched a test that uses nested PCR and
DNA sequencing to detect the presence of Borrelia burgdorferi, the bacterium that
causes Lyme disease.

The test, referred to as LoTemp, is being made available in the spring of 2010 prior to
the onset of the tick season. Other PCR-based tests for the indication exist, "{b}ut this
is the first … one using nested PCR for detection and DNA sequencing to
validate the molecular diagnosis in clinical laboratory medicine."

The assay, developed by Sin Hang Lee, a pathologist at Milford Hospital in Milford,
Conn., can be used before patients undergo traditional serology testing for the bug.
More than 30,000 people in the US are suspected to be infected with the spirochete B.
burgdorferi each year.

The test uses nested PCR to detect genomic DNA of B. burgdorferi in blood, and uses
Sanger-based DNA sequencing and diagnostic signature sequences found in GenBank
to validate the result, according to the statement. (The polymerase chain reaction
(PCR) is a scientific technique in molecular biology to amplify a single or a few
copies of a piece of DNA across several orders of magnitude, generating thousands to
millions of copies of a particular DNA sequence.)

Up to 75 percent of patients with "acute-phase Lyme disease are negative for the
characteristic antibodies, but in fact the percentage is higher," the statement said.
However, a negative result does not rule out the presence of the bacteria because
spirochetlemia, or the presence of spirochetes in the blood, "is transient and its time
points in Lyme {disease} vary from patient to patient."

"It is the marriage of {nested PCR and DNA sequencing} that minimizes
false-negatives to the lowest possible and eliminates false-positives known to be
associated with other Lyme disease DNA tests," it said."

The point is that the approach to Lyme disease detection and resolution has relied on
traditional allopathic approaches. However, Lyme Disease has a distinct energetic
signature and a process we call Bio-communications Diagnostics is designed to detect
and measure that energetic signature response. During a Bio-Communications
Diagnostic session, a computer generated stressor signal is send to the body. In
response to the stressor signal, an energetic signature signal is received back. This
response provides an energetic measurement showing the presence of Lyme related
bacterium associated with the Lyme Spirochetes. From this response, the presence of
Lyme can be confirmed and the Lyme bacterial load level in the body can be

2010, the good news is that the presence of Lyme in the body no longer has to be a
guessing game, nor does resolution of the disease have to include antibiotics.


Brown          University        Lyme          Disease        History         -

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