Anatomical Pathology by hjkuiw354

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									                                                                               Immunofluorescence study of
                                                                               utrophin in the muscle of an FHL1/
                                                                               MDX transgenic mouse.



Anatomical Pathology
Head: Professor catriona McLean Bsc, MBBs, FRcPA, MD



Research Activities                                                                    Neurotrauma brain bank Dr Tony Frugier (NTRI), Professor Catriona
 Cell-specific temporal infection of the brain in a simian                             McLean – Collaborating partner: National Trauma Research Institute (NTRI).
 immunodeficiency virus model of human immunodeficiency virus                          This study investigates the acute inflammatory response in the two weeks
 encephalitis Dr Katherine Thompson – This project utilised a macaque                  following human brain trauma including cytokine RNA expression and
 model of simian immunodeficiency virus (SIV) encephalitis to detect SIV               morphologic change.
 env DNA from laser micro-dissected brain cell populations at specific
                                                                                       JC virus latency in lymphocytes and spleen Eleanor Harrison – This
 time points to determine when and in which brain cells SIV infection
                                                                                       study was part of a BMedSc project investigating potential sites of latency
 occurred. The results showed that the virus entered early into the brain
                                                                                       for JC virus in the blood of healthy and immunosuppressed patients.
 with productive infection of perivascular macrophages. However, following
 acute infection, virus became undetectable. Re-entry of virus into the brain          Neuroimaging (using novel binders) of neurodegenerative diseases
 during late stage infection was via perivascular macrophages, rather than             Professor Catriona McLean – Collaborating partner: National Neuroscience
 re-activation of virus from a brain cell reservoir. Thus the perivascular             Foundation. This research highlights novel binders and their utility in the
 macrophage can be seen to be the ‘Trojan horse’. This work challenges                 neuroimaging diagnosis of Alzheimer’s disease.
 current notions of an HIV reservoir within latently infected, semi-permanent
 brain cells such as parenchymal microglia and astrocytes and was                      A study of TDP-43 in motor neurone disease Professor Catriona McLean –
 published in the Journal of NeuroVirology in 2009.                                    Collaborating partner: University of Melbourne. This research highlights a
                                                                                       possible novel cerebrospinal fluid marker of disease.
 HIV neuropathogenesis Dr Katherine Thompson – This research examines
 the timing and type of brain cells infected by HIV and the events that lead
 to the establishment of the virus in the brain. The overall hypothesis is that      Major Achievements
 the brain perivascular macrophage is a pivotal cell in relation to spread of        In 2009, Professor Catriona McLean was CIA on a successful five-
 systemic viral infections into the brain and, as such, represents the main          year NHMRC Enabling Grant to facilitate continued brain banking for
 focus for targeted treatment.                                                       neurodegenerative diseases. This grant runs through the Mental Health
                                                                                     Research Institute of Victoria. Professor McLean was CIA on two philanthropic
 Progressive multifocal leucoencephalopathy (PML) pathogenesis                       grants into neurodegenerative disease and was CIB on a successful NHMRC
 Dr Julianne Bayliss – This research examines the establishment of latent            Project Grant with Professor Christina Mitchell, Monash University, on a
 reservoirs of JC virus in the brain, blood and kidney of healthy patients.          project related to breast cancer. She is also one of multiple national and
                                                                                     international investigators on a five-year NIH grant administered by the
 Breast cancer sub-typing and epidemiology Professor Catriona McLean –
                                                                                     University of Melbourne that will investigate genetic causes of familial breast
 Collaborating partner: Cancer Council Victoria. This multinational study
                                                                                     cancer. Professor McLean continues her work as CI on three other NHMRC
 (with Cambridge University) highlights the relationship of various subtypes
                                                                                     Project Grants into multiple sclerosis, Alzheimer’s disease and breast cancer,
 of breast cancers with diet, environmental factors and a new prognostic
                                                                                     and as CIA on a Victorian Neurotrauma Initiative Grant for brain banking of
 marker in breast cancer.
                                                                                     neurotrauma.
 The role of phosphatases in breast cancer Professor Catriona McLean –
 Collaboration with Professor Christina Mitchell, Department of Biochemistry         She won a national citation award for outstanding contribution to student
 and Molecular Biology, Monash University. This study investigates a novel           learning from the Australian Learning and Teaching Council, and received
 tumour suppressor factor.                                                           an honourable mention from the Adelaide Medical Students’ Society in
                                                                                     recognition of teaching.
 The Australian Breast Cancer Family Study Professor Catriona McLean –
 Collaboration with Professor John Hopper, University of Melbourne. The              Eleanor Harrison received a Royal College of Pathologists of Australasia
 major goal is the maintenance and further collection of epidemiological,            medical student scholarship.
 genetic and pathology information from over 1,000 well-characterised
 population-based breast cancer families for the Breast Cancer Family
 Registry as well as the genetic testing for BRCA1 and BRCA2.
                                                                                        Postgraduate students                     Publications
 Analysing key molecules in multiple sclerosis Professor Catriona McLean –              1 PhD Student                             16 Journal Articles
 Collaboration with Professor Trevor Kilpatrick, University of Melbourne.


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