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Azithromycin cervicitis

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					Azithromycin
Azithromycin
   Brand Name:
     Zithromax

   Therapeutic Category:
     Antibacterial
          Azalide antibiotic, part of the macrolide family of
           antibacterials
Azithromycin
   Accepted Indications:
      Bronchitis or acute otitis media due to Haemophilus influenzae, Moraxella catarrhalis, or
        Streptococcus pneumoniae
              Not recommended as the first line of therapy for otitis media.
        Cervicitis or Urethritis due to Chlamydia trachomatis or Neisseria gonorrhoeae
        Chancroid - indicated in the treatment of genital ulcer disease in men due to Haemophilus
         ducreyi
        Mycobacterium avium complex (MAC) disease, disseminated (prophylaxis) - indicated in
         patients with advanced human immunodeficiency virus (HIV) infection
        Pelvic inflammatory disease due to Chlamydia trachomatis, Mycoplasma hominis, or
         Neisseria gonorrhoeae
        Pharyngitis or Tonsillitis due to Streptococcus pyogenes
        Community acquired pneumonia due to Chlamydia pneumoniae, Haemophilus influenzae,
         Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Staphylococcus
         aureus, or Streptococcus pneumoniae
        Skin and soft tissue infections due to Staphylococcus aureus, Streptococcus agalactiae, or
         Streptococcus pyogenes
        Acute bacterial sinusitis due to Haemophilus influenzae, Moraxella catarrhalis, or
         Streptococcus pneumoniae
Azithromycin
   Side Effects:
     Those   indicating need for medical attention:
        Thrombophlebitis (for injection form only)
        Acute interstitial nephritis

        Allergic reactions

        Pseudomembranous colitis
Azithromycin
   Side Effects (cont.):
     Those    indicating need for medical attention
      only if they continue or are bothersome:
        GI disturbances
        Dizziness

        Headache
Azithromycin
   Dosing Regimen:
      Usual adult dose
               Oral Suspension
                     Cervicitis, nongonococcal or Chancroid, in men or Urethritis, nongonococcal - 1 gram as a
                        single dose
                     Cervicitis, gonococcal or Urethritis, gonococcal - 2 grams as a single dose
               Tablets
                     Bronchitis, bacterial exacerbations or Pharyngitis, streptococcal or Pneumonia, due to
                        Chlamydia pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, or Streptococcus
                        pneumoniae or Skin and soft tissue infections or Tonsillitis, streptococcal - 500 mg as a single
                        dose on the first day, then 250 mg once a day on days 2-5
                     Cervicitis, nongonococcal or Urethritis, nongonococcal - 1000 mg as a single dose
                     Sinusitis, acute, bacterial - 500 mg a day for 3 days
                     Mycobacterium avium complex (MAC) disease, disseminated, prophylaxis - 1200 mg once a
                        week, alone or in combination with an approved dosing regimen of rifabutin
               Injection
                     Pelvic inflammatory disease - IV infusion, 500 mg as a single dose once a day for the first one
                        or two days of a 7 course of therapy
                     Pneumonia, due to Chlamydia pneumoniae, Haemophilus influenzae, Legionella pneumophila,
                        Moraxella catarrhalis, Mycoplasma pneumoniae, Staphylococcus aureus, or Streptococcus
                        pneumoniae - Intravenous infusion, 500 mg as a single dose once a day for at least the first two
                        days of a 7-10 day course of therapy
   Usual adult prescribing limits
      None
Azithromycin
   Auxiliary Labels:
     Oral   suspension
          For the pediatric suspension:
                Refrigerate
                Shake well
                Do not take with food
                Continue medicine for full time of treatment
          For the adult single dose packets:
                Reconstitute before taking
     Tablets
          Continue medicine for full time of treatment.
Azithromycin
   Monitoring Parameters: (major clinical
    significance)
     None
Azithromycin
   Available Dosage Forms:
       Tablets
            250 mg (Zithromax)
            500 mg (Zithromax)
            600 mg (Zithromax)
       Oral Suspension
            100 mg per 5 mL (when reconstituted according to manufacturer's
             instructions) (available in 300-mg bottles) (Zithromax)
            200 mg per 5 mL (when reconstituted according to manufacturer's
             instructions) (available in 600-, 900-, and 1200-mg bottles)
             (Zithromax)
            1 gram (Zithromax)
       For injection
            500 mg (Zithromax)
Azithromycin
   Contraindications:
     Hypersensitivityto azithromycin,
      erythromycins, or other macrolides
   Pregnancy Category B
Azithromycin
   Drug Interactions: (major clinical
    significance)
     Aluminum- and magnesium-containing
      antacids
Azithromycin
   Patient Consultation:
       Before using this medication
            Conditions affecting use, especially:
                Hypersensitivity to azithromycin, erythromycins, or other
                 macrolides
                Other medications, especially aluminum- and magnesium-
                 containing antacids
                Other medical problems, especially hepatic function impairment
       Proper use of this medication
            Azithromycin pediatric oral suspension should be given at least 1
             hour before or 2 hours after meals
            Azithromycin tablets and adult single dose oral suspension may be
             taken with or without food
            Compliance with full course of therapy
            Importance of not taking more medication than prescribed
            Importance of not discontinuing medication without checking with
             physician
Azithromycin
   Patient Consultation (cont.):
     Precautions      while using this medication
          Checking with physician if no improvement within a
           few days or if condition becomes worse
     Side/adverse       effects
          Signs of potential side effects, especially
           thrombophlebitis, acute interstitial nephritis, allergic
           reactions, and pseudomembranous colitis