Docstoc

Development of Mesoderm and derivatives of Paraxial Mesoderm and Lateral Plate of Mesoderm

Document Sample
Development of Mesoderm and derivatives of Paraxial Mesoderm and Lateral Plate of Mesoderm Powered By Docstoc
					             Objectives
Review Bilaminar germ disc
Have the knowledge of Trilaminar germ
 disc
Know the formation of Primitive Streak
 and Notochord
Explain the development and division of
 Mesoderm
Differentiation of Paraxial Mesoderm &
 Lateral Plate of Mesoderm
              Bilaminar Germ Disc
Bilaminar Germ Disc is
  present in second week
  of development. As
  name indicates it
  consists of two germ
  layers the dorsal layer is
  called as Epiblast and
  consists of tall columnar
  cells
The ventral layer is called
  as Hypoblast and
  consists of cuboidal
  cells
Development of Trilaminar Germ Layer
The first indication of 3rd
  week of development is
  the formation of 3rd layer
  that is Gastrulation.
The first sing of the
  gastrulation is the
  formation of Primitive
  Streak in the caudal part
  of embryo and this is the
  first sing for the
  formation of Mesoderm
  (third germ layer) in
  Embryo.
 Development of Third Germ Layer
The mesenchymal cells
  are migrate from the
  primitive steak in
  forward direction in
  the cranial part to
  form Notochord.
The mesenchymal cells
  still migrate forward
  on each side of
  notochord and
  differentiated into
  three regions
 Development of Third Germ Layer
Most medial part of
  mesoderm is the
Paraxial Mesoderm
  develops into
  Musculoskeletal
  System
Middle is
Intermediate Mesoderm
  develops into
  Genitourinary System
Most lateral is
Lateral Plate of
  Mesoderm develops
  into Body Wall
          Lateral Plate Mesoderm
The lateral plate
  mesoderm gives rise
  to the heart, blood
  vessels, and blood
  cells of the circulatory
  system, as well as to
  the lining of the body
  cavities and to all the
  mesodermal
  components of the
  limbs except the
  muscles.
Structures Develop from Mesoderm
1- Connective tissue                  8- Spleen
2- Cartilage                          9- Kidneys
3- Bone                               10- Ovaries
4- Striated and smooth muscles        11- Testes
5- Heart, blood, and lymphatic vessels 12- Genital
                                       ducts
6- Cortex of suprarenal glands
7- Serous membranes lining the body
cavities (pericardial, pleural, and
peritoneal)
             Paraxial Mesoderm
The skeletal system
  develops from paraxial
  and lateral plate (somatic
  layer) mesoderm and
  from neural crest.
  Paraxial mesoderm forms
  a segmented series of
  tissue blocks on each side
  of the neural tube, known
  as Somitomeres in the
  head region and Somites
  from the occipital region
  caudally.
          Differentiation of Somite
Somites differentiate into a
  ventromedial part:
The Sclerotome which
  develops into cartilages
  and bone
A dorsolateral part: the
  Dermomyotome which
  further subdivided into
  Dermatome which
  develops into Dermis and
Myotome Which develops
  into Skeletal Muscles
     Differentiation of Sclerotome
At the end of the fourth
 week, sclerotome cells
 become polymorphous
 and form a loosely
 woven tissue, the
 Mesenchyme, or
 embryonic connective
 tissue. They may
 become fibroblasts,
 chondroblasts, or
 osteoblasts (bone-
 forming cells).
         Somatic Mesoderm Layer
The bone-forming
  capacity of
  mesenchyme is not
  restricted to cells of the
  sclerotome but occurs
  also in the somatic
  mesoderm layer of the
  body wall, which
  contributes mesoderm
  cells for formation of
  the pelvic and shoulder
  girdles and the long
  bones of the limbs.
              Neural Crest Cells
Neural crest cells in
 the head region
 also differentiate
 into mesenchyme
 and participate in
 formation of
 bones of the face
 and skull.
       Differentiation of Myotome
With the exception of some
 smooth muscle tissue, the
 muscular system develops
 from the mesodermal
 germ layer and consists of
 skeletal, smooth, and
 cardiac muscle. Skeletal
 muscle is derived from
 Paraxial mesoderm, which
 forms somites from the
 occipital to the sacral
 regions and somitomeres
 in the head.
          Splanchnic Mesoderm
Smooth muscle
 differentiates from
 splanchnic
 mesoderm
 surrounding the gut
 and its derivatives
 and from ectoderm
 (pupillary,
 mammary gland,
 and sweat gland
 muscles).
   Development of Cardiac Muscles
Cardiac muscle is
 derived from
 splanchnic
 mesoderm
 surrounding the
 heart tube.
Review of Components of Mesoderm