Immunohistochemical Diagnosis of Renal Neoplasms by ProQuest

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									     Immunohistochemical Diagnosis of Renal Neoplasms
                                            Luan D. Truong, MD; Steven S. Shen, MD, PhD

N Context.—Histologic diagnosis of renal
usually straightforward by routine light
                                               neoplasm is
                                                microscopy.
                                                                        cell neoplasms derived from proximal tubules, including
                                                                        clear cell and papillary RCCs. Kidney-specific cadherin,
However, immunomarkers may be essential in several                      parvalbumin, claudin-7, and claudin-8 are sensitive mark-
contexts, including differentiating renal from nonrenal                 ers for renal neoplasms from distal portions of the nephron,
neoplasms, subtyping of renal cell carcinoma (RCC), and                 including chromophobe RCC and oncocytoma. CK7 and a-
diagnosing rare types of renal neoplasms or metastatic RCC              methylacyl coenzyme A racemase are sensitive markers for
i
								
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