Docstoc

Prof amnesia

Document Sample
Prof amnesia Powered By Docstoc
					Prof. Benjamin Lerer

List of Publications

Books:

Lerer, B., Weiner, R.D., Belmaker, R.H. (Editors.): ECT: Basic Mechanisms, John
Libbey, London, 1984. (Republished by American Psychiatric Press, Washington, D.C.,
1986).

Lerer, B., Gershon, S. (Editors.): New Directions in Affective Disorders, Springer-Verlag,
New York, 1989.

Lerer, B (Editor): Pharmacogenetics of Psychotropic Drugs. Cambridge University Press,
Cambridge, 2002.

Articles in Referred Journals and Book Chapters (by Topic)

General Hospital Psychiatry, Psychosomatics, Psychotherapy

Chajek, T., Lerer, B., Geltner, D., Levij, I.S.: Quinidine induced granulomatous hepatitis.
Annals of Internal Medicine 81: 774-776, 1974.

Lerer, B., Avni, J.: Suicide in a general hospital psychiatric department. Psychiatrica
Clinica 9: 106-111, 1976.

Lerer, B., Avni, J., Wiesel, D.: Bad tidings and the hospitalized patient. Mental Health
and Society 3: 205-211, 1976.

Lerer, B., Hyperhidrosis: A review of its psychological aspects. Psychosomatics 18: 28-
31, 1977.

Lerer, B.: Odyssey into the unknown - A resident's views on psychotherapy and
supervision. Israel Annals of Psychiatry and Related Disciplines 17: 74-80, 1979.

Lerer, B., Jacobowitz, J., Wahba, A.: Personality features in essential hyperhidrosis
International Journal of Psychiatry in Medicine 10: 59-67, 1980.

Lerer, B., Jacobowitz, J.: Treatment of essential hyperhidrosis by psychotherapy.
Psychosomatics 22: 536-538, 1981.

Hertz, D.G., Lerer, B.: The rape family - patterns of communication, interaction and
emotional reactions in the families of rape victims. International Journal of Family
Psychiatry 3-4: 301-315, 1982.

Lerer, B.: Essential hyperhidrosis: Psychological treatment. Harefuah 107: 156, 1984 (In
Hebrew). (Letter)


Lithium: Pre-clinical Psychopharmacology

Segal, M., Edelstein, E.L., Lerer, B.: Interaction between delta-6 tetrahydrocannabinol
(delta-6 THC) and lithium at the blood-brain barrier in rats. Experientia 34: 629, 1978.
Hermoni, M., Lerer, B., Ebstein, R.P., Belmaker, R.H.: Chronic lithium prevents
reserpine-induced supersensitivity of adenylate cyclase. Journal of Pharmacy and
Pharmacology 32: 510 -511, 1980.

Lerer, B., Ebstein, R.P, Felix, A., Belmaker, R.H.: Lithium amelioration of reserpine-
induced hypoactivity in rats. International Pharmacopsychiatry 15: 338-343, 1980.

Lerer, B., Ebstein, R.P., Belmaker, R.H.: Receptor mechanisms of lithium action in
affective disorders. In: Neurotransmitters and Their Receptors (Eds. Littauer, U. et al.),
John Wiley, London, 1980.

Belmaker, R.H., Lerer, B., Zohar, J., Ebstein, R.P.: Comparison of receptor and
adenylate cyclase theories of lithium action. In: Biological Psychiatry (Eds. Perris, C. et
al.), Elsevier, Amsterdam, 1981.

Lerer, B., Globus, M., Brik, E., Hamburger, R., Belmaker, R.H.: Effect of treatment and
withdrawal from chronic lithium in rats on stimulant induced responses.
Neuropsychobiology 11:28-32, 1984.

Lerer, B., Stanley, M.: Effect of chronic lithium on cholinergically mediated responses
and [3H] QNB binding in rat brain. Brain Research 344: 211-219, 1985.

Lerer, B., Stanley, M.: Does lithium stabilize muscarinic receptors? Biological Psychiatry
20: 1247-1248, 1985. (Letter)

Newman, M., Belmaker, R.H., Hamburger-Bar, R., Lerer, B. Receptor-mediated and
independent effects in the actions of lithium and electroconvulsive shock on adenylate
cyclase. In: Proceedings of the Alfred Benzon Symposium on Drug Action (Eds. Geisler,
A. et al.), Munksgaard, Copenhagen, 1986.

Lerer, B., Stanley, M., Gershon, S.: Lithium and brain cholinergic receptor regulation. In:
Perspectives in Psychopharmacology (Eds. Barchas, J., Bunney, W.F.), Alan R. Liss,
New York, 1988.

Newman, M., Lerer, B.: A comparison of the effects of lithium and antidepressant drugs
on second messenger systems in rat brain. In: New Directions in Affective Disorders
(Eds. Lerer, B. and Gershon, S.), Springer-Verlag, New York, 1989.

Roth, D., Hamburger-Bar, R., Lerer, B.: Peripheral versus central manifestations in the
toxic interaction of lithium and pilocarpine. Biological Psychiatry 25: 153-158, 1989.

Ebstein, R.P., Newman, M.E., Bennett, E.R., Lerer, B. Mechanism of action of lithium in
affective disorder: Modulation of post-receptor second messenger function. In: Topics in
Neurochemistry and Neuropharmacology: Biochemical and Pharmacological Aspects of
Depression Eds. Youdim, M.B.H., Tipton, K.F.), Taylor and Francis Ltd., London, 1989.

Newman, M.E., Shapira, B., Lerer, B.: Effects of lithium and desipramine on second
messenger responses in rat hippocampus: Relation to G-protein effects.
Neuropharmacology 30: 1297-1301, 1991.

Gur, E., Lerer, B., Newman, M.E.: Acute or chronic lithium does not affect agonist
stimulated inositol triphosphate formation in rat brain in vivo. NeuroReport 7:393-396,
1996.

Lithium: Clinical Psychopharmacology
Zohar, J., Lerer, B., Ebstein, R.P., Belmaker, R.H.: Lithium does not prevent agonist-
induced subsensitivity of human adenylate cyclase. Biological Psychiatry 17: 343-350,
1982.

Belmaker, R.H., Lerer, B., Klein, E., Hamburger, R.H.: The use of behavioral methods in
the search for compounds with lithium- like activity. In: Behavioral Models and the
Analysis of Drug Action (Eds. Spiegelstein, M.Y., Levy, A.), Elsevier, Amsterdam, 1982.

Belmaker, R.H., Lerer, B., Klein, E., Newman, M., Dick, E.: Clinical implications of
research on the mechanism of action of lithium. Progress in Neuropsychopharmacology
and Biological Psychiatry 7: 287-296, 1983.

Ebstein, R.P., Moscovich, D., Zeevi, S., Amir, Z., Lerer, B.: The effect of lithium in vitro
and following chronic treatment on human platelet adenylate cyclase activity: Post-
receptor modification of second messenger signal amplification. Psychiatry Research 21:
221-228, 1987.

Ebstein, R.P., Lerer, B., Bennett, E.R., Shapira, B., Kindler, S., Shemesh, Z.,
Gerstenhaber, N.: Lithium modulation of second messenger signal amplification in man:
Inhibition of phospholipase C and adenylate cyclase activity. Psychiatry Research 24: 45-
52, 1988.

Belmaker, R.H., Lerer, B., Newman, M.E., Fuchs, I: Lack of effect of lithium, propranolol
or haloperidol on basal plasma cyclic AMP levels. Lithium 2: 115-116, 1991.

Moscovich, D.G., Shapira, B., Lerer, B., Belmaker, R.H.: Rapid lithiumisation in acute
manic patients. Human Psychopharmacology 7: 343-345, 1992.

ECT and TMS (Pre-clinical): Neurochemistry

Globus, M., Lerer, B., Hamburger, R., Belmaker, R.H.: Chronic ECT and chronic
haloperidol are not additive in effects on DA receptors. Neuropharmacology 20: 1125-
1128, 1981.

Belmaker, R.H., Lerer, B., Bannet, J., Birmaher, B.: The effect of ECS at a clinically
equivalent schedule on rat cortical beta-adrenergic receptors. Journal of Pharmacy and
Pharmacology 34: 275, 1982.

Lerer, B., Jabotinsky-Rubin, K., Bannet, J., Ebstein, R.P., Belmaker, R.H.:
Electroconvulsive shock prevents dopamine receptor supersensitivity. European Journal
of Pharmacology 80: 131-134, 1982.

Birmaher, B., Lerer, B., Belmaker, R.H.: Lithium does not prevent ECS-induced
decreases in beta-adrenergic receptors. Psychopharmacology 78: 190-191, 1982.

Lerer, B., Stanley, M., Demetriou, S., Gershon, S.: Effect of electroconvulsive shock on
muscarinic cholinergic receptors in rat cerebral cortex and hippocampus. Journal of
Neurochemistry 41: 1680-1683, 1983.

Ebstein, R.P., Lerer, B., Shlaufman, M., Belmaker, R.H.: The effect of repeated
electroconvulsive shock treatment and chronic lithium feeding on the release of
norepinephrine from rat cortical vesicular preparations. Cellular and Molecular
Neurobiology 3:191-201, 1983.
Lerer, B.: Electroconvulsive shock and neurotransmitter receptors: Implications for the
mechanism of action and adverse effects of ECT. Biological Psychiatry 18: 361-383,
1984 (A.E. Bennet Award, 1983 - Honorable Mention).

Ebstein, R.P., Lerer, B., Shlaufman, M., Belmaker, R.H.: Effect of electroconvulsive
shock on noradrenaline release. In: ECT: Basic Mechanisms (Eds. Lerer, B. et al.), John
Libbey, London, 1984.

Lerer, B.: Studies on the role of brain cholinergic systems in the therapeutic mechanisms
and adverse effects of ECT and lithium (Winning Paper, A.E. Bennet Award, Basic
Science, 1984). Biological Psychiatry 20: 20-40, 1985.

Stanley, M., Lerer, B.: Electroconvulsive shock and brain cholinergic function: Role of
striatal muscarinic receptors. Convulsive Therapy 1: 158-166, 1985.

Newman, M.E. Salomon, H., Lerer, B.: Electroconvulsive shock and cyclic AMP signal
transduction: Effects distal to the receptor. Journal of Neurochemistry 46: 1667-1669,
1986.

Newman, M.E., Miskin, I., Lerer, B.: Effects of single and repeated electroconvulsive
shock administration on inositol phosphate accumulation in rat brain slices. Journal of
Neurochemistry 49:19-23, 1987.

Newman, M., Lerer, B.: Chronic electroconvulsive shock and desipramine reduce the
degree of inhibition by 5-HT and carbachol of forskolin-stimulated adenylate cyclase in rat
hippocampal membranes. European Journal of Pharmacology 148: 257-260, 1988.

Newman, M., Lerer, B.: Effects of chronic electroconvulsive shock on D1 and D2
dopamine receptor-mediated adenylate cyclase activity in rat striatal and limbic forebrain
homogenates. Neuropharmacology 28, 787-790, 1989.

Newman, M., Lerer, B.: Modulation of second messenger function in rat brain by in vivo
alteration of receptor sensitivity: Relevance to mechanism of action of electroconvulsive
therapy and antidepressants. Progress in Neuropsychopharmacology and Biological
Psychiatry 13: 1-30, 1989.

Gur, E., Berman, E., Lerer, B., Newman, M.E.: In vivo cyclic AMP responses in rat brain
are not modified by chronic electroconvulsive shock. European
Neuropsychopharmacology 7: 189-193, 1997.

Gur, E., Lerer, B., Newman, M.E.: Chronic electroconvulsive shock and 5-HT
autoreceptor activity in rat brain: An in vivo microdialysis study. Journal of Neural
Transmission 104: 795-804, 1997.

Gur, E., Lerer, B., Dremencov, E., Newman, M.E.: Chronic repetitive transcranial
magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor
activity in rat brain. NeuroReport 11: 2925-2929, 2000.

Gur, E., Dremencov, E., Garcia, F., Van de Kar, L.D., Lerer, B., Newman, M.E.:
Functional effects of chronic electroconvulsive shock on serotonergic 5-HT1A and 5-HT1B
receptor activity in rat hippocampus and hypothalamus. Brain Research 952: 52-60,
2002.

Gur, E., Lerer, B., Newman, M.E., Van de Kar, L.D.: Chronic rTMS induces subsensitivity
of post-synaptic 5-HT1A receptors in rat hypothalamus. (Submitted)
ECT (Pre-clinical): Memory

Lerer, B., Stanley, M., Altman, H.: ECT, acetylcholine receptors and memory. In:
Psychiatry: The State of the Art, Vol. 3: Psychopharmacology (Eds. Berner, P. et al ),
Plenum Press, New York, 1984.

Lerer, B., Altman, H., Stanley, M.: Enhancement of memory by a cholinesterase inhibitor
associated with muscarinic receptor down-regulation. Pharmacology, Biochemistry and
Behavior 21: 467-469, 1984.

Lerer, B., Stanley, M., McIntyre, I., Altman, H.: Electroconvulsive shock and brain
muscarinic receptors: Relationship to anterograde amnesia. Life Sciences 35: 2659-2664,
1984.

Lerer, B., Keegan, M., Stanley, M., Altman, H.: Pro-active and retroactive effects of
repeated electroconvulsive shock on passive-avoidance retention in rats. Physiology and
Behavior 36: 471-475, 1986.

Lerer, B., Stanley, M., Altman, H., Keegan, M.: An animal model of ECT-induced
amnesia: Possible neurochemical correlates. In: Electroconvulsive Therapy: Clinical and
Basic Research Issues (Eds. Malitz, S., Sackeim, H.), New York Academy of Sciences,
New York, 1986.

Hamburger-Bar, R., Kindler, S., Bertish, T., Lerer, B.: An active avoidance model of ECT
induced amnesia: Lack of effect of arginine vasopressin. In: Biological Psychiatry 1985
(Ed. Shagass, C. et al), Elsevier, New York, 1986.

Hamburger-Bar, R., Kindler, S., Bertish, T., Lerer, B.: Conditioned avoidance acquisition
and extinction following repeated electroconvulsive shock: Strain effect and response to
vasopressin. Biological Psychiatry 22: 593-602, 1987.

ECT: Clinical Research

Lerer, B., Zabow, T., Egnal, N., Belmaker, R.H.: Effect of vasopressin on memory
following ECT. Biological Psychiatry 18: 821-824, 1983.

Lerer, B., Shapira, B., Drexler, H., Calev, A., Newman, M.E.: Pharmacological
manipulation of ECT-induced seizure duration. Clinical Neuropharmacology 9 (Suppl.4):
453-455, 1986.

Shapira, B., Lerer, B., Gilboa, D., Drexler, H., Kugelmass, S., Calev, A.: Facilitation of
electroconvulsive therapy by caffeine pretreatment. American Journal of Psychiatry 144:
1199-1202, 1987.

Shapira, B., Kindler, S., Lerer, B.: Medication outcome in ECT-resistant depression.
Convulsive Therapy 4:192-198, 1988.

Calev, A., Ben-Tzvi, E., Shapira, B., Drexler, H., Carasso, R., Lerer, B.: Distinct memory
impairments following electroconvulsive therapy and imipramine. Psychological Medicine
19: 111-119, 1989.

Kindler, S., Lerer, B., Shapira, B., Drexler, H.: Pharmacological manipulation of seizure
duration: A new direction in ECT technology. In: New Directions in Affective Disorders
(Eds. Lerer, B., Gershon, S.), Springer-Verlag, New York, 1989.
Shapira, B., Kindler, S., Lerer, B.: Resistant depression: Clinical characteristics and
response to treatment. In: New Directions in Affective Disorders (Eds. Lerer, B.,
Gershon, S.), Springer-Verlag, New York, 1989.

Calev, A., Ben Tzvi, E., Shapira, B., Lerer, B.: Tricyclic antidepressants,
electroconvulsive therapy and memory in depressed patients. In: New Directions in
Affective Disorders (Eds. Lerer, B., Gershon, S.), Springer-Verlag, New York, 1989.

Bachar, E., Dasberg, H., Shapira, B., Lerer, B.: Reminiscing in depressed, ageing
patients: Effect of ECT and antidepressants. International Journal of Geriatric Psychiatry
5: 252-257, 1990.

Calev, A., Shapira, B., Nigal, D., Tubi, N., Chazan, S., Ben-Yehuda, Y, Kugelmass, S.,
Lerer, B.: Early and long-term effects of electroconvulsive therapy and depression on
memory and other cognitive functions. Journal of Nervous and Mental Diseases 179:
526-533, 1991.

Calev, A., Cohen, R., Tubi, N., Nigal, D., Shapira, B., Kugelmass, S., Lerer, B.:
Disorientation and bilateral, moderately suprathreshold, titrated ECT. Convulsive Therapy
7: 99-110, 1991.

Calev, A., Drexler, H., Tubi, N., Nigal, D., Shapira, B., Kugelmass, S., Lerer, B.: Atropine
and cognitive performance after ECT. Convulsive Therapy 7: 92-98, 1991.

Calev, A., Kochav-lev, E., Tubi, N., Nigal, D., Chazan, S., Shapira, B., Lerer, B.:
Change in attitude toward electroconvulsive therapy: Effects of treatment, time since
treatment and severity of depression. Convulsive Therapy 7: 184-189, 1991.

Kindler, S., Shapira, B., Hadjez, J., Abramowitz, M., Brom, D., Lerer, B.: Factors
influencing response to bilateral ECT in major depression. Convulsive Therapy 7: 245-
254, 1991.

Shapira, B., Hadjez, J., Calev, A., Lerer, B.: Schedule of ECT administration:
Implications for antidepressant efficacy and adverse effects. In: Proceedings of the 5th
World Congress of Biological Psychiatry (Eds. Racagni, G., et al), Elsevier, Amsterdam,
1991.

Shapira, B., Calev, A., Lerer, B.: Optimal use of electroconvulsive therapy: Choosing a
treatment schedule. Psychiatric Clinics of North America. 14: 935-946 1991.

Calev, A., Pass, H.L., Shapira, B., Fink, M., Tubi, N., Lerer, B.: ECT and memory. In:
ECT: From Research to Clinical Practice (Ed. Coffey, C.E.) American Psychiatric Press,
Washington, D.C., 1993.

Bloch, M., Admon, O., Bonne, O., Lerer, B.: Electroconvulsive therapy in a depressed,
heart transplant patient. Convulsive Therapy 8: 290-293, 1992.

Tubi, N., Calev, A., Nigal, D., Shapira, B., Fink, M., Pass, H.L., Jandorf, L., Lerer, B.:
Subjective symptoms in depression and during the course of ECT. Neuropsychiatry,
Neuropsychology and Behavioral Medicine 6: 187-192, 1993.

Zervas, I., Calev, A., Jandorf, L., Schwartz, J.E., Gaudino, E., Tubi, N., Lerer, B.,
Shapira, B.: Age dependent effects of electroconvulsive therapy on memory. Convulsive
Therapy 9: 39-43, 1993.
Lerer, B., Shapira S.: How resistant is resistant depression? Focus on electroconvulsive
therapy. European Neuropsychopharmacology 4: 211-212, 1994

Devanand, D.P., Shapira, B., Petty, F., Kramer, G., Fitzsimmons, L., Lerer, B., Sackeim,
H.A.: Effects of electroconvulsive therapy on plasma GABA. Convulsive Therapy 11: 3-
13, 1995.

Lerer, B., Shapira, B., Calev, A., Tubi, N., Drexler, H., Kindler, S., Lidsky, D., Schwartz,
J.E.: Antidepressant and cognitive effects of twice versus three times weekly ECT.
American Journal of Psychiatry 152: 564-570, 1995.

Shapira, B., Gorfine, M., Lerer, B.: A prospective study of lithium continuation therapy in
depressed patients who have responded to ECT. Convulsive Therapy 11: 80-85, 1995.

Segman, R.H., Shapira, B., Gorfine, M., Lerer, B.: Onset and time course of
antidepressant action: Psychopharmacological implications of a controlled trial of
electroconvulsive therapy. Psychopharmacology 119: 440-448, 1995.

Shapira, B., Lidsky, D., Gorfine, M., Lerer, B.: Electroconvulsive therapy and resistant
depression: Clinical implications of seizure threshold. Journal of Clinical Psychiatry 57:
32-38, 1996.

Shapira, B., Lerer, B.: Choosing a dosing strategy for electrical stimulation in ECT: Drs.
Shapira and Lerer reply. Journal of Clinical Psychiatry 57: 487-488, 1996 (Letter)

Shapira, B, Tubi, N., Drexler, H., Lidsky, D., Calev, A., Lerer, B.: Cost and benefit in the
choice of ECT schedule: A new controlled trial of twice versus three times weekly ECT.
British Journal of Psychiatry 172: 44-48, 1998.

Shapira, B., Lerer, B.: Speed of response to bilateral ECT: An examination of possible
predictors in two controlled trials. Journal of Electroconvulsive Therapy 15: 202-206,
1999.

Bachar, E., Shapira, B., Lerer, B.: Increment in reminiscing after ECT: Possible
connections to neuropsychological changes. Journal of Electroconvulsive Therapy
15:165-166, 1999 (Letter).

Shapira, B., Tubi, N., Lerer, B.: Balancing speed of response to ECT in major
depression and adverse cognitive effects: Role of treatment schedule. Journal of
Electroconvulsive Therapy 16:97-109, 2000.

ECT: Reviews, Hypotheses and Commentary

Lerer, B., Jabotinsky-Rubin, K., Belmaker, R.H.: ECT: Biological mechanism of action.
Harefuah 101: 211-223, 1981 (In Hebrew).

Lerer, B., Belmaker, R.H.: Receptors and the mechanism of action of ECT. Biological
Psychiatry 17: 497-511, 1982.

Lerer, B., Birmaher, B., Belmaker, R.H.: Electroconvulsive therapy: Role in psychiatric
treatment. The Family Physician 11: 75-80, 1982 (In Hebrew).
Lerer, B., Sitaram, N.: Clinical strategies for evaluating ECT mechanisms in humans -
pharmacological, biochemical and psycho-physiological approaches. Progress in Neuro-
psychopharmacology and Biological Psychiatry 7: 309-333, 1983.

Lerer, B., Belmaker, R.H.: ECT in our time (Editorial). Harefuah 105: 431-432, 1983 (In
Hebrew).

Lerer, B.: ECT and tardive dyskinesia. Journal of Clinical Psychiatry 45: 188, 1984.
(Letter)

Lerer, B., Stanley, M.: ECT-induced memory impairment - A cholinergic mechanism?
The Behavioral and Brain Sciences 7: 29-30 1984.

Lerer, B., Weiner, R.D., Belmaker, R.H.: Basic mechanisms of ECT: Introduction. In:
ECT: Basic Mechanisms (Eds. Lerer, B. et al.), John Libbey, London, 1984.

Lerer, B., Stanley, M., Belmaker, R.H.: ECT and lithium: Parallels and contrasts in
receptor mechanisms. In: ECT: Basic Mechanisms (Eds. Lerer, B. et al.), John Libbey,
London, 1984.

Lerer, B., Weiner, R.D., Belmaker, R.H.: ECT mechanisms: Current perspectives and
future directions. In: ECT: Basic Mechanisms (Eds. Lerer, B. et al.), John Libbey,
London, 1984.

Lerer, B.: ECT today: From empirical to rational. World Journal of Psychosynthesis 15:
32-33, 1984.

Lerer, B., Shapira, B.: Optimum frequency of ECT: Implications for clinical practice and
basic research (Editorial). Convulsive Therapy 2: 141-144, 1986.

Lerer, B., Shapira, B.: Neurochemical mechanisms of mood stabilization: Focus on ECT.
In: Electroconvulsive Therapy: Clinical and Basic Research Issues (Eds. Malitz, S.,
Sackeim, H.), New York Academy of Sciences, New York, 1986.

Shapira, B., Lerer, B.: Clinical response rate to ECT. Psychiatry Research 17: 247-248,
1986. (Letter)

Lerer, B.: Neurochemical and other neurobiological consequences of ECT: Implications
for the pathogenesis and treatment of affective disorders. In: Psychopharmacology: The
Third Generation of Progress (Ed. Meltzer, H.), Raven Press, New York, 1987.

Shapira, B. Kindler, S., Lerer, B.: Failure to convulse with ECT. British Journal of
Psychiatry 153: 413-414, 1988. (Letter)

Lichtenberg, P., Lerer, B.: Implications of clinical spectrum for mechanisms of action:
ECT and tricyclic antidepressants reconsidered. Convulsive Therapy 5: 216-226, 1989

Lerer, B., Shapira, B.: Twice versus thrice weekly ECT: Reply. Convulsive Therapy 5:
362-365, 1989. (Letter)

Shapira, B., Kindler, S., Lerer, B.: Electroconvulsive therapy. In: The Scientific Basis of
Psychiatry (Second Edition). (Eds. Weller, M.P.I., Eysenck, M.W.), Baillaire Tindall,
London, 1992.
Newman, ME., Gur, E., Shapira, B., Lerer, B.: Neurochemical mechanisms of action of
ECS: Evidence from in vivo studies. Journal of Electroconvulsive Therapy 14: 153-171,
1998.

Lerer, B.: The neurobiology of ECT: The road taken. Journal of Electroconvulsive
Therapy (Editorial) 14: 149-152, 1998.

Lerer, B.: The neurobiology of ECT: The road ahead. Journal of Electroconvulsive
Therapy (Editorial) 15: 1-4, 1999.

Lerer, B., Shapira, B.: Time dependent sensitization and ECT. Molecular Psychiatry 6:
500, 2001.

Antidepressants: Pre-clinical Psychopharmacology

Klein, E., Lerer, B., Newman, M., Belmaker, R.H., Bhargava, N.: The effect of Cyclo Leu-
Gly on reserpine-induced hypomotility and reserpine-induced increases in cortical beta-
adrenergic receptors. Psychopharmacology 83: 76-78, 1984.

Ebstein, R.P., Cohen, R., Lerer, B., Daly, J.W.: Calcium antagonists and
neurotransmitter release. In: Biological Psychiatry 1985 (Eds. Shagass, C. et al), Elsevier,
New York, 1986.

Newman, M.E., Lipot, M., Lerer, B.: Differential effects of chronic desipramine
administration on the cyclic AMP response in rat cortical slices and membranes.
Neuropharmacology 26: 1127-1130, 1987.

Newman, M.E., Lerer, B.: Effects of lithium and desipramine administration on inositol
phosphate accumulation in rat cerebral cortex. Biochemical Pharmacology 37:1991-1995,
1988

Newman, M.E., Lerer, B.: Changes in rat brain second messenger function on
administration of psychoactive drugs: Relationship to receptor number and
desensitisation. In: Progress in Catecholamine Research (Eds. Sandler, M. et al.), Alan
Liss, New York, 1988.

Newman, M., Lerer, B.: Post-receptor mediated increases in adenylate cyclase activity
after chronic antidepressant treatment: Relationship to receptor desensitisation.
European Journal of Pharmacology 162: 345-352, 1989.

Newman, M.E., Drummer, D., Lerer, B.: Single and combined effects of desipramine and
lithium on serotonergic receptor number and second messenger function in rat brain.
Journal of Pharmacology and Experimental Therapeutics 252: 826 -831, 1990

Newman, M.E., Lerer, B.: 5-HT-1A receptor-mediated effects of antidepressants:
Relation to G protein function. Clinical Neuropharmacology, 13 (Suppl 2): 237-238, 1990.

Newman, M.E., Ben-Zeev, A., Lerer, B.: Choramphetamine did not prevent the effects of
chronic antidepressants on 5-HT inhibition of forskolin-stimulated adenylate cyclase in rat
hippocampus. European Journal of Pharmacology 207: 209-213, 1991.

Newman, M.E., Shapira, B., Lerer, B.: Regulation of 5-HT-1a receptor function in rat
hippocampus by short- and long-term administration of 5-HT-1a agonists and
antidepressants. Journal of Pharmacology and Experimental Therapeutics 260: 16-20,
1992.
Newman, M.E., Lerer, and B., Shapira, B.: 5-HT-1a receptor mediated effects of
antidepressants. Progress in Neuropsychopharmacology and Biological Psychiatry 17: 1-
19, 1993

Gur, E., Lerer, B., Newman, M.E.: Chronic clomipramine and triiodothyronine increase 5-
HT levels in rat frontal cortex in vivo: Relationship to 5-HT autoreceptor activity Journal of
Pharmacology and Experimental Therapeutics 288: 81-87, 1999.

Gur, E., Dremencov, E., Lerer, B., Newman, M.E.: Venlafaxine: Acute and chronic
effects on 5-HT levels in rat brain in vivo. European Journal of Pharmacology 272: 17-24,
1999.

Dremencov, E., Gur, E., Lerer, B., Newman, M.E.: Subchronic fluoxetine administration
to rats: Effects on 5-HT autoreceptor activity as measured by in vivo microdialysis.
European Neuropsychopharmacology 10: 229-236, 2000.

Newman, M.E., Agid, O., Gur, E., Lerer, B.: Pharmacological mechanisms of T3
augmentation of antidepressant action. International Journal of
Neuropsychopharmacology 3: 187-191, 2000.

Newman, M.E., Gur, E., Dremencov, E., Garcia, F., Lerer, B., Van de Kar, L.D.: Chronic
clomipramine alters presynaptic 5-HT-1B and postsynaptic 5-HT-1A receptor sensitivity in
rat hypothalamus and hippocampus respectively. Neuropharmacology 39: 2309-2317,
2000.

Gur, E., Dremencov, E., Lerer, B., Newman, M.E.: Functional effects of corticosterone on
serotonergic 5-HT1A and 5-HT1B receptor activity in rat hippocampus and hypothalamus:
In vivo microdialysis studies. European Journal of Pharmacology 411: 115-123, 2001.

Gur, E., Dremencov, E., Van de Kar, L.D., Lerer, B., Newman, M.E.: Effects of
chronically administered venlafaxine on serotonin receptor activity in rat hippocampus
and hypothalamus. European Journal of Pharmacology 436: 57-65, 2002.

Dremencov, E., Gur, E., Lerer, B., Newman, M.E.: Effects of chronic antidepressants and
electroconvulsive shock on serotonergic neurotransmission in the rat hypothalamus.
Progress in Neuro-Psychopharmacology and Biological Psychiatry 26: 1029– 1034, 2002

Gur, E., Lifschytz, T, Lerer, B., Newman, M.E.: Effects of triiodothyronine and
imipramine on basal 5-HT levels and 5-HT1 autoreceptor activity in rat cortex. European
Journal of Pharmacology 457: 37-43, 2002.

Dremencov, E., Gur, E., Lerer, B., Newman, M.E.: Effects of chronic antidepressants and
electroconvulsive shock on serotonergic neurotransmission in the rat hippocampus.
Progress in Neuro-Psychopharmacology and Biological Psychiatry (In Press).

Gur, E., Lifschytz, T, Van de Kar, L.D., Lerer, B., Newman, M.E.: Effects of
triiodothyronine on 5-HT1A and 5-HT1B autoreceptor activity, and postsynaptic 5-HT1A
receptor activity in rat hypothalamus. (Submitted).


Antidepressants: Clinical Psychopharmacology
Belmaker, R.H., Lerer, B., Ebstein, R.P., Dasberg, H.: The adrenergic receptor as the
locus of antidepressant therapy in humans. In: Neurotransmitters and Their Receptors
(Eds. Littauer, U. et al.), John Wiley, London,1980.

Belmaker, R.H., Lerer, B., Ebstein, R.P.: Noradrenaline, dopamine and mood. In:
Advances in the Biosciences, Vol. 31: Recent Advances in Neuropsychopharmacology
(Eds. Angrist, B. et al.), Pergamon Press, Oxford, 1981.

Lerer, B., Ebstein, R.P., Belmaker, R.H.: Subsensitivity of beta-adrenergic adenylate
cyclase after salbutamol treatment in depression. Psychopharmacology 75: 169-172,
1981.

Belmaker, R.H., Lerer, B., Zohar, J.: Salbutamol treatment of depression. In: Advances
in Biochemical Psychopharmacology: Typical and Atypical Antidepressants (Eds. Costa,
E., Racagni, G.), Raven Press, New York, 1982.

Zohar, J., Lerer, B., Belmaker, R.H.: Tricyclic-resistant depression: Responses to
receptor manipulation with salbutamol, propranolol, estrogen and vasopressin. In:
Biological Psychiatry 1985 (Eds. Shagass, C. et al), Elsevier, New York, 1986.

Zohar, J., Lerer, B., Belmaker, R.H.: Beta-adrenergic agonists as a potential treatment
for resistant depression. In: Treating Resistant Depression (Eds. Zohar, J., Belmaker,
R.H.), PMA Publishing Corporation, New York, 1987.

Shapira, B., Yagmur, M.J., Newman, M.E., Lerer, B.: Lithium supplementation therapy in
refractory depression: Clinical aspects and neuroendocrine challenge effects. In:
Biological Psychiatry (Eds. Racagni, G., et al.), Elsevier, Amsterdam,1991.

Lichtenberg, P., Shapira, B., Blacker, M., Gropp, C., Calev A., Lerer, B.: Effect of
fenfluramine on mood: A double- blind, placebo-controlled trial. Biological Psychiatry
31:351-356. 1992.

Bloch, M., Schwartzman, Y., Bonne, O., Lerer, B.: Concurrent treatment of major
depression with desipramine and lithium: A double blind, placebo controlled study.
Journal of Clinical Psychopharmacology 17:44-48, 1997.

Agid, O., Lerer, B.: Common errors in the prescription of psychotropic drugs. Harefuah
131: 451-452, 1997 (In Hebrew) (Letter).

Kasper, S., Bech, P., De Jonghe F., De Sousa, M.P., Dinan, T., Guelfo, J.D., Higuchi, T.,
Larsen, J.K., Lecrubier, J.P., Lerer, B., Neumeister, A., Papadimitriou, G., Paykel, E.S.,
Poldinger, W., Svestka, J., Walter, H.: Treatment of unipolar major depression: algorithms
for pharmacotherapy. International Journal of Psychiatry in Clinical Practice 1(Suppl. 1):
S5-S7, 1997.

Gelfin, Y., Gorfine, M., Lerer, B.: Effect of clinically equivalent fluoxetine administration
on mood and other psychological parameters in healthy volunteers. American Journal of
Psychiatry 155: 290-292, 1998

Reus, V.I., Lerer, B.: Cosmetic psychopharmacology: Do antidepressants modify normal
behavior? No impact on individuals without psychiatric illness. Medical Crossfire 7: 44-55,
1999.

Agid, O., Lerer, B.: Algorithm based treatment of major depression in an outpatient clinic:
Clinical correlates of response to a specific serotonin reuptake inhibitor and to
triiodothyronine augmentation. International Journal of Neuropsychopharmacology (In
Press).

Carbamazepine and Other Mood Stabilisers

Klein, E., Bental, E., Lerer, B., Belmaker, R.H.: Combination of carbamazepine and
haloperidol versus placebo and haloperidol in excited psychoses: A controlled study.
Archives of General Psychiatry 41: 165-170, 1984.

Belmaker, R.H., Klein, E., Lerer, B.: A comparison of carbamazepine with lithium in
excited psychoses. In: The Use of Anticonvulsants in Affective Disorders (Ed. Emrich,
H.M.), Elsevier, Amsterdam, 1984.

Belmaker, R.H., Klein, E., Lerer, B.: Carbamazepine in excited psychosis. In: Psychiatry,
The State of the Art, Vol. 3: Psychopharmacology (Eds. Berner, P. et al) Plenum Press,
New York, 1984.

Lerer, B., Moore, N., Meyendorff, E., Cho, S. R., Gershon, S.: Carbamazepine and
lithium: Different profiles in affective disorders? Psychopharmacology Bulletin 21: 18-22,
1985.

Moore. N., Lerer, B., Meyendorff, E., Gershon, S.: Three cases of carbamazepine
toxicity. American Journal of Psychiatry 142: 974-975, 1985.

Lerer, B.: Alternative therapies for bipolar disorder. Journal of Clinical Psychiatry (Del
Amo Award Paper) 46: 309-316, 1985.

Meyendorff, E., Lerer, B., Moore, N., Bow, J., Gershon, S.: Methylphenidate infusion in
euthymic bipolars: Effect of carbamazepine pretreatment. Psychiatry Research 16: 303-
308, 1985

Moore, N., Lerer, B., Meyendorff, E., Gershon, S.: Carbamazepine in the acute
treatment of mania. In: Biological Psychiatry 1985 (Eds. Shagass, C. et al), Elsevier, New
York, 1986.

Lerer, B., Moore, N., Meyendorff, E., Cho, S-R., Gershon, S.: Carbamazepine versus
lithium in mania: A double blind study. Journal of Clinical Psychiatry 48: 89-93, 1987.

Other Clinical Psychopharmacology

Agid, O., Lerer, B.: Risperidone augmentation of paroxetine in a case of severe,
treatment refractory obsessive compulsive disorder without comorbid psychopathology.
Journal of Clinical Psychiatry 60: 55-56, 1999 (Letter).

Schreiber, S., Kampf-Sherf, O., Gorfine, M., Kelly, D., Oppenheim, Y., Lerer, B.: An open
trial of plant source derived phosphatidylserine for treatment of age-related cognitive
decline. Israel Journal of Psychiatry 37: 302-307, 2000

Psychoneuroendocrinology

Bannet, J., Lerer, B., Ebstein, R.P., Ben David, M., Belmaker, R.H.: Lack of effect of
beta-2 adrenergic stimulation on human prolactin. Psychoneuroendocrinology 6: 177-179,
1981.
Lerer, B., Ran, A., Blacker, M., Silver, H., Weller, M.P.I., Drummer, D., Ebstein, B.,
Calev, A.: Neuroendocrine responses in chronic schizophrenia: Evidence for
serotonergic dysfunction. Schizophrenia Research 1: 405-410, 1988

Shapira, B., Reiss, A., Kaiser, N., Kindler, S., Lerer, B.: Effect of imipramine treatment
on the prolactin response to fenfluramine and placebo challenge in depressed patients.
Journal of Affective Disorders 16: 1-4, 1989.

Shapira, B., Kindler, S., Gropp, C., Newman, M., Ebstein, B., Lerer, B.: Neuroendocrine
evidence for a serotonergic mechanism common to electroconvulsive therapy and
imipramine. In: Antidepressants -Thirty Years On. (Eds. Leonard, B., Spencer, P.),
Clinical Neuroscience Publishers, London, 1990

Lesch, K.P., Lerer, B.: The 5-HT receptor-G protein-effector system complex in
depression: I. Effect of glucocorticoids. Journal of Neural Transmission 84: 3-18, 1991.

Shapira, B., Lerer, B., Kindler, S., Lichtenberg, P., Gropp, C., Ebstein, B., Cooper, T.B.,
Calev, A: Enhanced serotonergic responsivity following electroconvulsive therapy in
patients with major depression. British Journal of Psychiatry 160: 223-229, 1992.

Shapira, B., Yagmur, M.J., Gropp, C., Newman, M.E., Lerer, B.: Effect of clomipramine
and lithium on fenfluramine-induced hormone release in major depression. Biological
Psychiatry 31: 975-983, 1992.

Lichtenberg, P., Shapira, B., Gillon, D., Cooper, T.B., Newman, M.E., Lerer, B.:
Hormone responses to fenfluramine and placebo challenge in endogenous depression.
Psychiatry Research 43: 137-146, 1992.

Shapira, B., Newman, M.E., Lerer, B.: Serotonergic mechanisms of ECT:
Neuroendocrine evidence. Clinical Neuropharmacology 1 (Suppl. 1): 673-674, 1992.

Shapira, B., Cohen, J., Newman, M.E., Lerer, B.: Prolactin response to fenfluramine and
placebo challenge following maintenance pharmacotherapy withdrawal in remitted
depressed patients. Biological Psychiatry 33: 531-535, 1993

Gelfin, Y., Lerer, B., Lesch, KP., Gorfine, M., Allolio, B.: Complex effects of age and
gender on adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge
in normal subjects. Psychopharmacology 120: 356-364, 1995.

Lerer, B., Gillon, D., Lichtenberg, P., Gorfine, M., Gelfin, Y., Shapira, B.: Interrelationship
of age, depression and central serotonergic function: Evidence from fenfluramine
challenge studies. International Psychogeriatrics 8: 83-102, 1996.

Newman, M.E., Shapira, B., Lerer, B.: Evaluation of central serotonergic function in
affective and related disorders by the fenfluramine challenge test: a critical review.
International Journal of Neuropsychopharmacology 1: 49-70, 1998.

Lerer, B., Gelfin Y., Gorfine M,. Allolio, B., Lesch, K.P., Newman, M.E.: 5-HT1A receptor
function in normal subjects on clinical doses of fluoxetine: Blunted temperature and
hormone responses to ipsapirone challenge. Neuropsychopharmacology 20: 628-639,
1999.

Newman, M.E., Li, Q., Gelfin, Y., Van de Kar, L.D., Lerer, B.: Low doses of ispsapirone
increase growth hormone but not oxytocin secretion in normal male and female subjects.
Psychopharmacology 145: 99-104, 1999.
Lerer, B., Gelfin, Y., Shapira, B.: Neuroendocrine evidence for age-related decline in
central serotonergic function. Neuropsychopharmacology 21: 321-2, 1999 (Letter).

Shapira, B., Newman. M.E., Gelfin, Y., Lerer, B.: Blunted temperature and hormone
responses to ipsapirone in major depression: Lack of enhancement by electroconvulsive
therapy. Psychoneuroendocrinology 25: 421-438, 2000.

Affective Disorders: Neurobiology

Lerer, B., Birmaher, B., Ebstein, R.P., Belmaker, R.H.: 48-hour depressive cycling
induced by antidepressant. British Journal of Psychiatry 137: 183-185, 1980.

Ebstein, R.P., Lerer, B., Bennett, E.R., Newman, M.E., Shapira, B., Kindler, S.: Second
messenger function in lymphocytes and platelets: A comparison of peripheral and central
mechanisms. Clinical Neuropharmacology 9 (Suppl.4): 350-352, 1986.

Ebstein, R.P., Bennett, E.R., Stessman, J., Lerer, B.: Isoelectric focusing of human
platelet phospholipase C: Evidence for multimolecular forms. Life Sciences 40: 161-167,
1987

Ebstein, R.P., Lerer, B., Shapira, B., Kindler, S., Shemesh, Z.: Cyclic AMP second
messenger signal amplification in depression. British Journal of Psychiatry 152: 665-
669,1988.

Kindler, S., Lerer, B.: Norepinephrine and depression : A reappraisal. In: Biological
Basis of Psychiatric Treatment. (Eds. Pohl, R. and Gershon, S.), S. Karger A.G, Basel,
1990.

Newman, M.E., Shapira, B., Lichtenberg, P., Lerer, B.: Second messenger signal
transduction associated with 5-HT in the pathogenesis and treatment of affective
disorders. In: Biological Psychiatry (Eds. Racagni, G., et al.), Elsevier, Amsterdam, 1991.

Newman, M.E., Lerer, B., Lichtenberg, P., and Shapira, B.: Platelet adenylate cyclase
activity in depression and after clomipramine and lithium treatment: Relation to
serotonergic function. Psychopharmacology 109: 234, 1992.

Shapira, B., Newman, M.E., Lerer, B.: Serotonergic mechanisms in depression: Clinical
insights and biological correlates. Israel Journal of Medical Science 30: 162-167, 1994.

Affective Disorders: Clinical

Calev, A., Korin, Y., Shapira, B., Kugelmass, S., Lerer, B.: Verbal and nonverbal recall
by depressed and euthymic affective patients. Psychological Medicine 16: 789-794,1986.

Lichtenberg, P., Navon, R., Wertman, E., Dasberg, H., Lerer, B.: Post partum psychosis
in adult GM2 gangliosidosis. British Journal of Psychiatry 153: 387-389, 1988.

Lerer, B., Gershon, S.: New Directions in Affective Disorders: Introduction. In: New
Directions in Affective Disorders (Eds. Lerer, B., Gershon, S.), Springer-Verlag, New
York, 1989.

Bachar, E, Calev, A., Shapira, B., Lerer, B.: Memories in depression: Pleasant or
unpleasant? British Journal of Psychiatry 157: 623-624, 1990. (Letter)
Bachar, E., Kindler, S., Dasberg, H., Schefler G., Lerer B.: Reminiscing as a technique in
the group psychotherapy of depression: A comparative study. British Journal of Clinical
Psychology 30: 375-377, 1991.

Bloch, M., Lerer, B.: Periodic changes in the incidence of depression in the current
century: Is the world marching towards an age of depression? Harefuah 125: 412-415,
1993. (In Hebrew).

Schreiber, S., Lerer, B.: “Failure to thrive” in depressed elderly patients: A new concept
or a different name for an old problem? Israel Journal of Psychiatry. 34:108-114, 1997

Agid, O., Kotek, S., Lerer, B.: Depression: From Ancient Greece to modern times -
Aetiology, diagnosis and treatment. Harefuah 131: 598-603, 1997 (In Hebrew).

Shapira, B., Zislin, J., Gelfin., Y., Osher, Y., Gorfine, M., Souery, D., Mendlewicz, J.,
Lerer, B.: Social adjustment and self esteem in remitted patients with unipolar and
bipolar affective disorder: A case control study. Comprehensive Psychiatry 40: 24-30,
1999.

Agid, O., Shapira, B., Zislin, J., Ritsner, M., Hanin, B., Murad, H., Troudart, T., Bloch, M.,
Heresco-Levy, U., Lerer, B.: Environment and vulnerability to major psychiatric illness: A
case control study of early parental loss in major depression, bipolar disorder and
schizophrenia. Molecular Psychiatry 4: 163-172, 1999.

Lerer, B., Shapira B., Bloch M., Hanin B., Troudart T., Alexander JR, Popper M., Braun
D., Segman RH., Ritsner M.: Possible precipitants of psychiatric hospitalisation in
patients with major depression: Results from the Jerusalem Collaborative Depression
Project. Depression and Anxiety 9: 156-162, 1999.

Canetti, L., Bachar, E., Bonne, O., Agid, O., Lerer, B., Kaplan De-Nour A., Shalev, A.Y.:
The impact of parental death versus separation from parents on the mental health of
Israeli adolescents. Comprehensive Psychiatry 41: 360-368, 2000.

Agid, O., Kohn, Y., Lerer, B.: Environmental stress and psychiatric illness. Biomedicine
and Pharmcotherapy.54: 135-141, 2000.

Kohn, Y., Zislin, J., Agid, O., Hanin, B., Troudart, T., Shapira, S., Bloch, M., Gur, E.,
Ritsner, M., Lerer, B.: Increased prevalence of negative life events in subtypes of major
depressive disorder. Comprehensive Psychiatry 42: 57-63, 2001.

Schizophrenia

Calev, A., Berlin, H., Lerer, B.: Remote and recent memory in long-hospitalized chronic
schizophrenics. Biological Psychiatry 22: 79-85,1987.

Calev, A., Korin, Y., Kugelmass, S., Lerer, B.: Performance of chronic schizophrenics on
matched verbal and nonverbal recall tasks. Biological Psychiatry 22: 699-709, 1987.

Chazan, S., Calev, A., Gil, T., Tubi, N., Amiri, Z., Lerer, B.: A study of the discriminating
power of the Wechsler Memory Scale using schizophrenic and normal subjects in Israel
Israel Journal of Psychiatry 24: 179-190, 1987.

Silver, H., Blacker, M., Weller, M.P.I., Lerer, B.: Treatment of chronic schizophrenia with
cyproheptadine. Biological Psychiatry 25: 502-504, 1989.
Ebstein, R.P., Bennett, E.R., Hadjez, J., Silver, H., Yedgar, S., Lerer, B.: Cyclic AMP
second messenger signal generation in EBV-transformed lymphoblastoid cells from
schizophrenic patients. Journal of Psychiatric Research 24: 121-127,1990.

Itzchaky, S., Lerer, B., Ebstein, R.P.: Uptake of [3H] spiperone to lymphocytes in
schizophrenia. Journal of Psychiatric Research 23: 221-227, 1990.

Bennett, E.R., Yedgar, S., Lerer, B., Ebstein, R.P.: Phospholipase A2 activity in Epstein-
Barr virus transformed lymphoblast cells from schizophrenic patients. Biological
Psychiatry 29: 1058-1062, 1991.

Silver, H., Blacker, M., Weller, M.P.I., Lerer, B.: Treatment of chronic schizophrenia with
cyproheptadine: A double-blind, placebo controlled study. Biological Psychiatry 30: 52-
525, 1991.

Calev, A., Nigal, D., Kugelmass, S., Weller, M.P.I., Lerer, B.: Performance of long stay
schizophrenics after drug withdrawal on matched immediate and delayed recall tasks.
British Journal of Clinical Psychology 30: 241-245, 1991.

Calev, A., Edelist, S., Kugelmass, S., Lerer, B.: Performance of long stay schizophrenics
on matched verbal and visuospatial recall tasks. Psychological Medicine 21: 655-660,
1991.

Silver, H., David, D., Kaplan, M., Tubi, N., Hadjez, J, Calev, A., Lerer, B.: Factor analysis
of schizophrenic symptoms and comparison of different rating scales. Schizophrenia
Research 10: 67-75. 1993.

Silver, H., Lerer, B.: The psychopathological dimensions of schizophrenia. In: Scripta
Hierosolymitana: Studies in Psychology (Eds. Ben Shakhar, G., Leiblich. A.) Magnes
Press, Jerusalem, 1995.

Rigbi,, A., Shalev-Mevorach, L., Taller, A., Taller, Y, and Lerer, B.: Relationship of
clinical and demographic characteristics of schizophrenia patients to rehabilitation status.
Israel Journal of Psychiatry (In Press).

Antipsychotic Drugs

Goldman, Z., Ebstein, R.P., Lerer, B., Zohar, J., Hermoni, M., Belmaker, R.H.:
Haloperidol blood levels during dosage reduction in chronic schizophrenic patients.
Neuropsychobiology 7: 281-284, 1981.

Globus, M., Bannet, J., Lerer, B., Belmaker, R.H.: The effect of chronic bromocriptine
and L-dopa on spiperone binding and apomorphine induced stereotypy.
Psychopharmacology 78: 81-84, 1982.

Heresco-Levy, U., Greenberg, D., Wittman, L., Dasberg, H., Lerer, B.: Prescribing
patterns of neuroactive drugs in 98 schizophrenic patients. Israel Journal of Psychiatry
26: 157-163, 1989

Nigal, D., Calev, A., Kugelmass, S., Lerer, B.: Effect of four week neuroleptic and
anticholinergic drug withdrawal on memory function in chronic, long stay schizophrenics.
Annals of Clinical Psychiatry 3: 141-145, 1991.
Heresco-Levy, U., Greenberg, D., Lerer, B., Dasberg, H., Brown, W.A: Trial of
maintenance neuroleptic dose reduction in chronic schizophrenic outpatients: Two year
outcome. Journal of Clinical Psychiatry 54: 59-62, 1993.

Heresco-Levy, U., Greenberg, D., Lerer, B., Brown, W.A.: Two year trial of neuroleptic
maintenance dose reduction in the treatment of schizophrenic outpatients: Predictors of
relapse. Israel Journal of Psychiatry 32: 268-75, 1995.

Heresco-Levy, U., Greenberg, D., Lerer, B., Javitt, D.C., Brown, W.A.: Serum
neuroleptic levels during reduced dose fluphenazine decanoate maintenance therapy.
Israel Journal of Psychiatry and Related Sciences 4: 281-289, 1997.

Posttraumatic Stress Disorder

Bleich, A., Siegel, B., Garb, R and Lerer, B.: Posttraumatic stress disorder following
combat exposure: Clinical features and psychopharmacological treatment. British Journal
of Psychiatry 149: 365-369, 1986.

Garb, R., Bleich, A., Lerer, B.: Bereavement in combat. Psychiatric Clinics of North
America 10: 421-436, 1987.

Lerer, B., Ebstein, R.P., Shestatzky, M., Shemesh, Z., Greenberg, D.: Cyclic AMP
signal transduction in posttraumatic stress disorder. American Journal of Psychiatry 144:
1324-27, 1987.

Lerer, B., Bleich, A., Garb, R., Herzberg, M., Levin, B.: Posttraumatic stress disorder in
Israeli combat veterans: Effect of phenelzine treatment. Archives of General Psychiatry
44: 976981, 1987.

Shestatzky, M., Greenberg, D., Lerer, B.: A controlled trial of phenelzine in post traumatic
stress disorder. Psychiatry Research 24: 149-155,1988.

Lerer, B., Ebstein, R.P.: Alterations in cyclic AMP signal amplification as a consequence
of chronic stress. In: Progress in Catecholamine Research (Ed. Belmaker, R.H. et al.),
Alan Liss, New York, 1988.

Lerer, B.: Differences among patients with PTSD: Reply. American Journal of Psychiatry
145: 656, 1989. (Letter)

Lerer, B., Braun, P., Bleich, A., Greenberg, D. Pharmacotherapy trials in post traumatic
stress disorder: Problems and prospects. In: New Directions in Affective Disorders (Eds.
Lerer, B., Gershon, S.), Springer-Verlag, New York, 1989.

Calev, A., Gil, T., Greenberg, D., Kugelmass, S., Lerer, B.: Cognitive functioning in post-
traumatic stress disorder. Journal of Traumatic Stress, 3:29-45, 1990.

Lerer, B., Bleich, A., Solomon, Z., Shalev, A., Ebstein, R.P.: Platelet adenylate cyclase
activity as a possible biological marker for posttraumatic stress disorder. In: Posttraumatic
Stress Disorder : Etiology, Pharmacology and Treatment (Eds. Wolf, M.B., Mosnaim,
A.D.), American Psychiatric Press, Washington D.C., 1990

Bleich, A., Attias, Y., Dagan, Y., Lavie, P., Shalev, A., Lerer, B.:
Psychoneurophysiological characteristics of combat veterans with posttraumatic stress
disorder. Clinical Neuropharmacology 13(Suppl 2): 334-335, 1990.
Braun, P., Greenberg, D., Dasberg, H., Lerer, B.: Core symptoms of posttraumatic
stress disorder unimproved by alprazolam treatment. Journal of Clinical Psychiatry
51:236-238, 1990.

Lerer, B., Bleich, A., Bennett, E.R., Ebstein, R.P., Balkin, J.: Platelet adenylate cyclase
and phospholipase C activity in posttraumatic stress disorder. Biological Psychiatry 27:
735-740,1990

Lerer, B., Dolev, A., Bleich, A., Ebstein, R.P.: Posttraumatic stress disorder and major
depression: An integrated perspective. Clinical Neuropharmacology 13(Suppl.2) 332-333,
1990.

Solomon, Z., Bleich, A., Koslovski, M., Kron, S., Lerer, B., Weisman, M.: Posttraumatic
stress disorder: Issues of co-morbidity. Journal of Psychiatric Research 25: 89-94, 1991.

Weizmann, R., Gur, E., Laor, N., Reiss, A., Miller, U., Yoresh, A., Lerer, B., Newman,
M.E.: Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks
with post-traumatic stress disorder. Psychopharmacology 114: 509-512, 1994.

Bleich, A., Dolev, A., Koslowsky, M., Vuzer, Y., Lerer, B.: Psychiatric morbidity after
psychological trauma. Harefuah 126: 493-496, 1994. (In Hebrew)

Lerer, B., Gur, E., Bleich, A., Newman, M.E.: Peripheral adrenergic receptors in post
traumatic stress disorder. In: Catecholamine Function in Post Traumatic Stress Disorder:
Emerging Concepts. (Ed. Murburg, M.) American Psychiatric Press, Washington D.C.,
1994.

Kohn, Y., Newman, M.E., Lerer, B., Orr, S.P., Pitman, R.K.: Absence of reduced platelet
adenylate cyclase activity in Vietnam veterans with PTSD. Biological Psychiatry 37: 205-
208, 1995.

Bleich, A., Koslowsky, M., Dolev, A., Lerer, B.: Post-traumatic stress disorder and
depression: An analysis of comorbidity. British Journal of Psychiatry 170: 479-482, 1997.

Agid, O., Shalev A.Y., Lerer, B.: Triiodothyronine augmentation of specific serotonin
reuptake inhibitors in posttraumatic stress disorder. Journal of Clinical Psychiatry 62: 169-
173, 2001.

Psychiatric Genetics: Affective and Other Disorders

Alexander, R.J., Lerer, B., Baron, M: Ethical issues in genetic linkage studies of
psychiatric disorder. British Journal of Psychiatry 160: 98-102, 1992.

Baron, M., Freimer, N.F., Risch, N., Lerer, B., Alexander J.R., Straub R.E., Asokan, S.,
Das, K., Peterson A., Amos, J., Endicott, J.E., Ott, J., Gilliam, C.: Diminished support for
linkage between manic depressive illness and X-chromosome markers in three Israeli
pedigrees. Nature (Genetics) 3: 49-55, 1993.

Baron, M., Endicott, J., Lerer, B., Loth, J.E., Alexander, J.R., Simon, R., Sharpe, L.,
Gibbon, M., Hasin, D., Lilliston, B., Shacht, S., Blumenthal, R., Alexander, J.R., Verter, A.,
Tubi, N., Fieve, R.R., Gilliam, T.C., Lehner, T., Ott, J.: A pedigree series for mapping
disease genes in bipolar affective disorder: Sampling, assessment and analytic
considerations. Psychiatric Genetics 4: 43-55, 1994.
Straub, R.E., Lehner, T., Luo, Y., Loth, J.E., Shao, W., Sharpe, L., Alexander, J.R., Das,
K., Simon, R., Fieve, R.R., Lerer, B., Endicott, J., Ott, J., Gilliam, T., Baron, M.: A
possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature
(Genetics) 8; 291-296, 1994.

Baron, M., Straub, R.E., Lehner, T., Endicott, J., Ott, J., Gilliam, T.C., Lerer, B.: Bipolar
disorder and linkage to Xq28. Nature (Genetics) 7: 461, 1994 (Letter).

Alexander, J. R., Benjamin, J., Lerer, B., Baron, M., Belmaker, R. H.: Frequency of
positive family history in bipolar patients in a catchment area population. Progress in
Neuropsychopharmacology and Biological Psychiatry 19: 367-373, 1995.

Kotler, M., Cohen, H., Segman, R., Gritsenko, I., Nemanov, L., Lerer, B., Kramer, I., Zer-
Zion, M., Kletz, I., Ebstein, R.P.: Excess dopamine D4 (DRD4) exon III seven repeat
allele in opioid dependent subjects. Molecular Psychiatry 2: 251-254, 1997.

Knowles, J.A., Rao, P.A., Cox-Matise, T., Loth, J.E., de Jesus, G.M., Levine, L., Das, K.,
Penchaszadeh, G.K., Alexander, J.R., Lerer, B., Endicott, J., Ott, J., Gilliam, T.C., Baron,
M.: No evidence for significant linkage between bipolar affective disorder and
chromosome 18 pericentromeric markers in a large series of multiplex extended
pedigrees. American Journal of Human Genetics 62: 916-924, 1998.

Souery, D., Lipp, O., Mahieu, B., Serretti, A., Cavallini, C., Ackenheil, M., Adolfsson, R.,
Aschauer, H., Blackwood, D., Dam, H., de Bruyn, A., Demartelaer, V., Dikeos, D.,
Fuchshuber, S., Heiden, M., Jablensky, A., Kessing, L., Lerer, B., Macedo, A., Mellerup,
T., Milanova, V., Muir, W., Nylander, P.O., Oruc, L., Papadimitriou, G.N., Pekkarinen, P.,
Peltonen, L., Pinto de Azevedo, M.H., Pull, C., Shapira, B., Smeraldi, E., Staner, L.,
Stefanis, C., Verga, M., Verheyen, G., Macciardi, F., Van Broeckhaven, C., Mendlewicz,
J.: European collaborative project on affective disorders: Interactions between genetic
and psychosocial vulnerability factors. Psychiatric Genetics 8: 197-205, 1998

Aita, V.M., Liu, J., Knowles, J.A., Terwilliger, J.D., Baltazar, R., Grunn, A., Loth, J.E.,
Kanyas, K., Lerer, B., Endicott, J., Wang, Z., Penchaszadeh, G., Gilliam, T.C., Baron, M.:
A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a
putative bipolar affective disorder locus. American Journal of Human Genetics 64: 210-
217, 1999.

Souery, D., Lipp, O., Mahieu, B., Serretti, A., Rivelli, S.K., Cavallini, C., Ackenheil, M.,
Adolfsson, R., Aschauer, H., Blackwood, D., Dam, Dikeos, D., Fuchshuber, S., Heiden,
M., Jablensky, A., Jakoveljevic, M., Kessing, L., Lerer, B., Mellerup, T., Milanova, V.,
Muir, W., Nylander, P.O., Oruc, L., Papadimitriou, G.N., Pekkarinen, P., Peltonen, L., Pull,
C., Raeymaekers, P., Shapira, B., Smeraldi, E., Staner, L., Stefanis, C., Verga, M.,
Verheyen, G., Macciardi, F., Van Broeckhoven, C., Mendlewicz, J.: Tyrosine hydroxylase
polymorphism and phenotypic heterogeneity in bipolar affective disorder: A multicenter
association study. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88:
527-532, 1999.

Segman, R.H., Lerer, B.: Genetic factors in the etiology of bipolar disorder. In: Soares, J.,
Gershon, S. (Eds.) Bipolar Disorders: Basic Mechanisms and Therapeutic Implications.
Marcel Dekker, New York, 2000.

Frisch, A., Michaelovsky, E., Rokach, R., Amir, I., Hermesh, H., Laor, N., Fuchs, C.,
Zohar, J., Lerer, B., Buniak, S.F., Landa, S., Poyurovsky, M., Shapira, B., Weizmann, R.:
Association between obsessive compulsive disorder and polymorphisms of genes
encoding components of the serotonergic and dopaminergic pathways. European
Neuropsychopharmacology. 10: 205-209, 2000.

Souery, D., Van Gestel, S., Massat, I., Blairy, S., Adolfsson, R., Blackwood, D., Del-
Favero, J., Dikeos, D., Jakoveljevic, R., Kaneva, E., Latuada, E., Lerer, B., Lilli, R.,
Milanova, V., Muir, W., Noethen, M., Oruc, L., Papadimitriou, G.N., Propping, P., Serretti,
A., Shapira, B., Smeraldi, E., Stefanis, C., Thomson, M., Van Broeckhoven, C.,
Mendlewicz, J.M.: Tryptophan hydroxylase polymorphism and suicidality in unipolar and
bipolar affective disorders: a multicenter association study. Biological Psychiatry 49: 405-
409, 2001.

Parasol, N., Cohen, N., Zemishlany, Z., Lerer, B., Kossower, N.S.: Duffy antigen receptor
for chemokines (DARC): Genotypes in Ashkenazi and non-Ashkenazi Jews in Israel.
Human Biology 73: 307-313, 2001.

Nimgaonkar, V.L., Faraone, S.V., Lerer, B., Mallet, J., Sherrington, R., Maier, W.: Impact
of overlapping recruitment on psychiatric genetic studies. American Journal of Medical
Genetics (Neuropsychiatric Genetics) 105: 139-140, 2001.

Liu, J., Juo, S-H., Teerwilleger, J.D., Aita V.M., Knowles J.A., Terwilliger, J.D., Grunn, A.,
Tong, X., Brito, M., Loth, J.E., Kanyas, K., Lerer, B., Endicott, J., Wang, Z.,
Penchaszadeh, G.K., Gilliam, T.C., Baron, M.: A follow-up linkage study supports
evidence for a bipolar affective disorder locus on chromosome 21q22. American Journal
of Medical Genetics (Neuropsychiatric Genetics) 105: 189-194, 2001.

Cichon, S., Schmidt-Wolf, G., Schumacher, J.., Muller, D.J., Hurter, M., Schulze, T.G,,
Albus, M., Borrmann-Hassenbach, M., Franzek, E., Lanczik, M., Fritze, J., Kreiner, R.,
Weigelt, B., Minges, J., Lichtermann, D., Lerer, B., Kanyas, K., Strauch, K., Windemuth,
C., Baur, M.P., Wienker, T.F., Maier, W., Rietschel, M., Propping, P., Nothen, M.M.: A
susceptibility locus for bipolar affective disorder in chromosomal region 10q25-q26.
Molecular Psychiatry 6: 342-349, 2001.

Lerer, B., Macciardi, F., Segman, R.H., Adolfsson, R., Blackwood, D., Blairy, S., Del-
Favero, J., Dikeos, D., Kaneva, E., Lilli, R., Massat, I., Milanova, V., Muir, W., Noethen,
M., Oruc, L., Petrova, T., Papadimitriou, G.N., Rietschel, M., Serretti, A., Souery, D., Van
Gestel, S., Van Broeckhoven, C., Mendlewicz, J.M.: Variability of 5-HT2C receptor
cys23ser polymorphism among European populations and vulnerability to affective
disorder. Molecular Psychiatry 6: 579-585, 2001.

Cichon, S., Schumacher, J., Muller, D.J., Hurter, M., Windemuth, C., Strauch, K.,
Hemmer, S., Schulze, T.G., Schmidt-Wolf, G., Albus, M., Borrmann-Hassenbach, M.,
Franzek, E., Lanczik, M., Fritze, J., Kreiner, R., Reuner, U., Weigelt, B., Minges, J.,
Lichtermann, D., Lerer, B., Kanyas, K., Baur, M.P., Wienker, T.F., Maier, W., Rietschel,
M., Propping, P., Nothen, M.M.: A genome screen for genes predisposing to bipolar
affective disorder detects a new susceptibility locus on 8q. Human Molecular Genetics
10:2933-2944, 2001.

Lerer, B., Yakir, A.: Heterogeneity of course and outcome in bipolar disorder: Can
genetics help? In: Maj, M., Akiskal, H.S., Lopez-Ibor, J.J., Sartorius, N. (Editors): World
Psychiatric Association Series, Evidence and Experience in Psychiatry. Volume 5: Bipolar
Disorder. Wiley , Chichester, 2002.

Massat, I., Souery, D., Del-Favero, J., Van Gestel, S., Serretti, A., Macciardi, F.,
Smeraldi, E., Kaneva, R., Adolfsson, R., Nylander, P.O., Blackwood, D., Muir, W.,
Papadimitriou, G.N., Dikeos. D., Oruc, L., Segman, R,H,, Ivezic, S., Aschauer, H.,
Ackenheil, M., Fuchshuber, S., Dam, H., Jakovljevic, M., Peltonen, L., Hilger, C.,
Hentges, F., Staner, L., Milanova, V., Jazin, E., Lerer, B., Van Broeckhoven, C.,
Mendlewicz, J.: Positive association of dopamine D2 receptor polymorphism with bipolar
affective disorder in a European multicenter association study of affective disorders.
American Journal of Medical Genetics (Neuropsychiatric Genetics) 114:177-85, 2002.

Liu, J., Juo1, S.H., Dewan, A., Grunn, A., Tong, X., Brito, M., Park, N., Loth, J.E.,
Kanyas, K., Lerer, B., Endicott, J., Penchaszadeh, G., Knowles, J.A., Ott, J., Gilliam,
T.C., Baron, M.: Evidence for a putative bipolar disorder locus on 2p13–16 and other
potential loci on 4q31, 7q34, 8q13, 9q31, 10q21–24, 13q32, 14q21 and 17q11–12.
Molecular Psychiatry 8: 333–342, 2003.

Lerer, B., Agid, O., Macciardi, F.: Pharmacogenetics of mood disorders: Is there a future:
In: Kasper S, Den Boer JA, Sitsen JMA (Eds.) Handbook of Depression and Anxiety, 2nd
Edition. Marcel Dekker, New York, 2003.

Mendlewicz, J., Massat, I., Souery, D., Del-Favero, J., Oruč, L., Nöthen, M.M.,
Blackwood, D., Muir, W., Battersby, S., Lerer, B., Segman, R.H., Kaneva, R., Serretti, A.,
Lilli, R., Lorenzi ,C., Jakovljevič, M., Ivezič, S., Rietschel1, M., Milanova1, V., Van
Broeckhoven, C.: Serotonin transporter 5HTTLPR polymorphism and affective disorders:
no association found in a large European multicenter study. (Submitted).

Psychiatric Genetics: Schizophrenia

Mulcrone, J., Marchbanks, R., Whatley, S.A., Wildenauer, D., Ebstein, R.P., Daoud, H.,
Altmark, D., Gur, E., Lerer, B.: Genetic linkage analysis of schizophrenia using
chromosome 11q13-24 markers in Israeli pedigrees. American Journal of Medical
Genetics (Neuropsychiatric Genetics) 60: 103-108, 1995.

Schwab, S.G., Lerer, B., Albus, M., Maier, W., Hallmayer, J., Fimmers, R., Lichtermann,
D., Minges, J., Thoma, V., Bondy, B., Ackenheil, M., Altmark, D., Hasib, D., Gur, E.,
Ebstein, R.P., Wildenauer, D.B.: Potential linkage for schizophrenia on chromosome
22q12-q13: A replication study. American Journal of Medical Genetics (Neuropsychiatric
Genetics) 60: 436-443, 1995

Schwab, S.G., Albus, M., Hallmayer, J., Honig, S., Borrmann, M., Lichtermann, D.,
Ebstein, R.P., Ley-Reuss, E., Ackenheil, M., Minges, J., Lerer, B., Risch, N., Maier, W.,
Wildenauer, D.B.: Evaluation of a susceptibility gene for schizophrenia on chromosome
6p by multipoint affected sib pair linkage analysis. Nature (Genetics) 11: 325-327, 1995.

Kossower, N.S., Gerad, L., Goldstein, M., Parasol, N., Zipser, Y., Avivi, L., Ragolsky, M.,
Rosenzwaig, S., Elkabetz, E., Abromovitz, Y., Lerer, B., Weizmann, A.: Constitutive
heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia.
American Journal of Medical Genetics (Neuropsychiatric Genetics). 60: 133-138, 1995.

Schizophrenia Collaborative Linkage Group (Israel: Lerer, B., Ebstein, R.P.): Additional
support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study.
Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. American
Journal of Medical Genetics (Neuropsychiatric Genetics) 67:580-594, 1996.

Schizophrenia Collaborative Linkage Group (Israel: Lerer B., Ebstein R.P.) A combined
analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus
for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group
(Chromosome 22). American Journal of Medical Genetics (Neuropsychiatric Genetics)
67: 40-45, 1996.
Wildenauer, D.B., Hallmayer, J., Schwab, S.G., Albus, M., Eckstein, G. N., Zill, P., Honig,
S., Strauss, M., Borrmann, M., Lichtermann, D., Ebstein, R.P., Lerer, B., Risch, N.,
Maier, W.: Searching for susceptibility genes in schizophrenia by genetic linkage
analysis. Coldspring Harbor Symposia on Quantitative Biology, Vol LXI, Coldspring
Harbor Laboratory Press, 61:845-850, 1996.

Maier, W., Minges, J., Eckstein, G.N. , Brodski, C., Albus, M., Lerer, B., Hallmayer, J.,
Fimmers, R., Ackenheil, M., Ebstein, R.P., Borrmann, R., Lichtermann, D., Wildenauer,
D.B.: Genetic relationship between dopamine transporter gene and schizophrenia:
Linkage and association. Schizophrenia Research 20: 175-180, 1996.

Wildenauer, D.B., Schwab, S.G., Eckstein, G.N. , N., Zill, P.J., Hruschka, K., Meier, M.K.,
Strauss, M., Ackenheil, M., Borrmann, R., Albus, M., Hallmayer, J., Lichtermann, D.,
Minges, J., Ebstein, R.P., Lerer, B., Maier, W., (1996) Gegenwaertiger stand der
kopplungsuntersuchungen bei schizophrenie In: Aktuelle Perspektiven der Biologischen
Psychiatrie. H.-J.Moeller (Hrsg), Springer Verlag, 1996.

Ebstein, R.P., Macciardi, F., Blaine, D., Serretti, A., Gur, E., Verga, M., Nemanov, L.,
Belmaker, R.H., Avnon, M., Lerer, B.: Evidence for an association between the
dopamine D3 receptor gene (DRD3) and schizophrenia. Human Heredity 47: 6-16, 1997.

Schwab, S.G., Eckstein, G.N., Hallmayer, J., Lerer, B., Albus, M., Borrmann, R.,
Lichtermann, D., Ertl, M.A., Maier, W., Wildenauer, D.B.: Evidence suggestive of a locus
on chromosome 5q31 contributing to susceptibility for schizophrenia in German and
Israeli families by multipoint affected sib-pair linkage analysis. Molecular Psychiatry. 2:
156-160, 1997.

Segman, R.H., Ebstein, R.P., Heresco-Levy, U., Gorfine, M., Avnon, M., Gur, E.,
Nemanov, L., Lerer, B.: Schizophrenia, chronic hospitalisation and the 5-HT2C receptor
gene. Psychiatric Genetics 7: 75-78, 1997.

Dann, J., DeLisi, L.E., Devoto, M., Laval, S., Shields, G., Smith, A., Loftus, Peterson, P.,
Vita, A., Comazzi, M., Morganti, C., Levinson, D.F., Wildenauer, D.B., Nancarrow, D.J.,
Mowry, B., Collier, D., Powell, J., Crowe, R.R., Andreasen, N.C., Silverman, J.M., Mohs,
R.C., Murray, R., Walters, M.K., Lennon, D.P., Hayward, N.K., Albus, M., Lerer, B.,
Maier, W., Crow, T.J: A linkage study of schizophrenia to markers within Xp11 near the
MAO-B gene. Psychiatry Research 70:131-143, 1997.

Schwab, S.G., Hallmayer, J., Hanses, C., Albus, M., Lerer, B., Kanyas, K., Segman, R.,
Borrmann, R., Dreikorn, B., Lichtermann, D., Rietschel, M., Held, T., Ertl, M.A., Maier, W.,
Wildenauer, D.B.: Further evidence for a susceptibility locus on chromosome 10p14-p11
in 72 families with schizophrenia by non parametric linkage analysis American Journal of
Medical Genetics (Neuropsychiatric Genetics) 81:302-307, 1998.

Schwab, S.G., Hallmayer, J., Lerer, B., Albus, M., Borrmann, M., Honig, S., Straub, M.,
Hanses, Segman, R., Lichtermann, D., C., Knapp, M., Trixler, M., Maier, W., Wildenauer,
D.B.: Support for a chromosome 18p locus conferring susceptibility to functional
psychoses in families with schizophrenia by association and linkage analysis. American
Journal of Human Genetics 63: 1139-1152, 1998.

Schizophrenia Collaborative Linkage Group (Israel: Lerer, B.): A transmission
disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further
support for a susceptibility locus for schizophrenia at 22q12. Schizophrenia Collaborative
Linkage Group for Chromosome 22. Schizophrenia Research 32: 115-21, 1998
Wittekindt O, Schwab SG, Burgert E, Knapp M, Albus M, Lerer B, Hallmayer J, Rietschel
M,, Segman R, Borrmann M, Lichtermann D, Crocq M-A, Maier W, Morris-Rosendahl DJ,
Wildenauer, DB Association between hSKCa3 and schizophrenia not confirmed by
transmission disequilibrium test in 193 offspring/parents trios. Molecular Psychiatry 4:
267-270, 1999.

Wildenauer D.B., Schwab, S.G., Maier, W., Lerer, B.: Searching for genes in
schizophrenia. Acta Neuropsychiatrica 11:50-53, 1999.

Hranilovic, D., Schwab, S.G., Jernej, B., Knapp, M., Lerer, B., Albus, M., Rietschel, M.,
Kanyas K., Borrmann, M., Lichtermann D., Maier, W., Wildenauer D.B.: Serotonin
transporter gene and schizophrenia: evidence for association/linkage disequilibrium in
families with affected siblings as obtained by transmission disequilibrium test. Molecular
Psychiatry. 5 :91-5, 2000.

Levinson, D.F., Holmans, P., Straub, R.E., Owen, M.J., Wildenauer, D.B., Gejman, P.V.,
Pulver, A.E., Laurent, C., Kendler, K.S., Walsh, D., Norton, N., Williams, N.M., Schwab,
S.G., Lerer, B., Mowry, B.J., Sanders, A.R., Antonarakis, S.E., Blouin, J.L., DeLeuze,
J.F., Mallet, J.: Multicenter linkage study of schizophrenia candidate regions on
chromosomes 5q, 6q, 10p and 13q: Schizophrenia Linkage Collaborative Group III.
American Journal of Human Genetics 67: 652-663, 2000.

Schwab, S.G., Hallmayer, J., Albus, M., Lerer, B., Eckstein, G.N., Borrmann, M.,
Segman, R., G.N., Hanses, C., Freymann, J., Yakir, A., Kanyas, M., Falkai, P., Rietschel,
M., Maier, W., Wildenauer, D.B.: A genome-wide screen for schizophrenia susceptibility
loci in 71 families with affected siblings: Support for loci on chromosome 10p and 6.
Molecular Psychiatry. 5: 638-649, 2000.

Sklar, P., Schwab, S.G., Williams, N.M., Daly, M., Schaffner, S., Maier, W., Albus, M.,
Trixler, M., Eichhammer, P., Lerer, B., Hallmayer, J., Norton, N., Williams, H., Zammit,
S., Jones, L., Sanders, R., McCarthy, G., Milanova, V., Kirov, G., O’Donovan, M., Lander,
E.S., Owen, M.J., Wildenauer. D.B.: Association analysis of NOTCH4 loci using family
and population based controls. Nature (Genetics) 28: 126-128, 2001

Levinson, D.F., Holmans, P.A., Laurent, C., Riley, B., Pulver, A.E., Gejman, P.V.,
Schwab, S.G., Williams, N.M., Owen, M.J., Wildenauer, D.B., Sanders, A.R., Nestadt, G.,
Mowry, B.J. Wormley, B., Bauché, S., Soubigou, S., Ribble, R., Nertney, D.A., Liang,
K.Y., Martinolich, L., Maier, W., Norton, N., Williams, H., Albus, M., Carpenter, B.,
deMarchi, N., Ewen-White, K.R., Walsh, D., Jay, M., Deleuze, J-F., O'Neill, F.A.,
Papadimitriou, G., Weilbaecher, A., Lerer, B., O`Donovan, M.C., Dikeos, D., Silverman,
J.M., Kendler,, K.S., Mallet, J., Crowe, R.R., Walters, M.: No major schizophrenia locus
detected on chromosome 1q in a large multicenter sample. Science 296: 739-741, 2002.

Segman, R.H., Shapira, Y., Modai, I., Hamdan, A., Zislin, J., Heresco-Levy, U., Kanyas,
K., Hirschmann, S., Karni, O., Finkel, B., Schlafman, M., Lerner, A., Shapira, B.,
Macciardi, F., Lerer, B.: Angiotensin converting enzyme gene insertion deletion
polymorphism: Case control association studies in schizophrenia, major affective disorder
and tardive dyskinesia and a family based association study in schizophrenia. American
Journal of Medical Genetics (Neuropsychiatric Genetics) 114: 310-314, 2002.

Schwab, S.G., Hallmayer,J., Freimann, J., Lerer, B., Albus, M., Borrmann-Hassenbach,
M., Segman, R.H., Trixler, M., Rietschel, M., Maier, W., Wildenauer, D.B.: Investigation of
linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-
alleles in 69 sib-pair- and 89 trio-families with schizophrenia. American Journal of Medical
Genetics (Neuropsychiatric Genetics) 114: 315-320, 2002.

Schwab, S.G., Knapp, M., Mondabon, S., Hallmayer, J., Borrmann-Hassenbach, M.,
Albus, M. Lerer, B., Trixler, M., Maier, W., Wildenauer, D.B.: Support for association of
schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families
with linkage and in an additional sample of triad families. American Journal of Human
Genetics 72:185-190, 2003.

Schwab, S.G., Mondabon, S., Knapp, M., Albus, M., Hallmayer, J., Borrmann-
Hassenbach, M., Trixler, M., Groß, M, Schulze, T., Lerer, B., Maier, W., Wildenauer,
D.B.: Association of tumor necrosis factor alpha gene -G308A polymorphism with
schizophrenia. Schizophrenia Research (In Press).

Kohn, Y., Lerer, B.: Genetics of schizophrenia: A review of linkage findings. Israel
Journal of Psychiatry. 39: 240-251, 2002.

Lerer, B., Segman, R.H., Hamdan, A., Kanyas, K., Karni, O., Kohn, Y., Korner, M.,
Lanktree, M., Kaadan, M., Turetsky, N., Yakir, A., Kerem, B., Macciardi, F.: Genome scan
of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23
and supports a locus at chromosome 10q24. Molecular Psychiatry (In Press).

Yakir, A., Kohn, Y., Albus, M., Kanyas, K., Karni, O., Borrmann-Hassenbach, M.,
Turetsky, N., Mandel, M., Rietschel, M., Schwab, S.G., Segman, R.H., Wildenauer, D.B,
Lerer, B.: Schizophrenia subsyndromes - sib-pair analysis and disease dimensions in
diverse affected samples (Submitted).

Segman, R.H., Modai, I., Yakir, A., Nemanov, L., Hirschmann, S., Hamdan, A., Zislin, J.,
Kanyas, K., Karni, O., Karni, O., Turetsky, N., Macciardi, F., Ebstein, R.P., Lerer, B.
Linkage disequilibrium studies of schizophrenia with chromosome 1q and chromosome
8p microsatellite markers in Jewish Israeli nuclear families. (Submitted).

Psychiatric Genetics: Pharmacogenetics

Kohn, Y., Ebstein, R.P., Heresco-Levy, U., Shapira, B., Nemanov., L., Gritsenko, I.,
Avnon, M., Lerer, B.: Dopamine D4 receptor gene polymorphisms: Relation to ethnicity,
schizophrenia and response to clozapine in Israeli subjects. European
Neuropsychopharmacology 7: 39-43, 1997

Amar, A., Segman, R.H., Shtrussberg, S., Sherman, L., Safirman, C., Lerer, B., Brautbar,
C.: Granulocytopenia in clozapine treated schizophrenia may be associated with HLA-
DBQ1*0201. International Journal of Neuropsychopharmacology 1: 41-44, 1998.

Segman, R., Neeman, T., Heresco-Levy U., Finkel, B., Karagacev, L., Schlafman, M.,
Dorevitch, A., Yakir, A., Lerner, A., Shelevoy, A., Lerer, B.: Genotypic association
between the dopamine D3 receptor and tardive dyskinesia in chronic schizophrenia.
Molecular Psychiatry 4: 247-253, 1999.

Segman, R.H., Lerer, B.: Genetic susceptibility to tardive dyskinesia in chronic
schizophrenia: The potential role of candidate genes. In: Franzek, E., Ruther, E., Ungvari
GS, Beckmann, H. (Eds.) Progress in Differentiated Psychopathology. Wuerzburg
University Press, Wuerzburg, 2000.

Segman, R.H., Heresco-Levy U., Finkel, B., Inbar, R., Neeman, T., Schlafman, M.,
Dorevitch, A., Yakir, A., Lerner, A., Shelevoy, A., Lerer, B.: Association between the
serotonin 2C receptor gene and tardive dyskinesia in chronic schizophrenia; additive
contribution of 5-HT2Cser and DRD3gly alleles to susceptibility. Psychopharmacology 152:
408-413, 2000.

Segman, R.H., Heresco-Levy U., Finkel, B., Goltser, T., Shalem, R., Schlafman, M.,
Dorevitch, A., Yakir, A., Greenberg, D., Lerner, A., Lerer, B.: Association between the
serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. Molecular
Psychiatry 6: 225-229, 2001.

Segman, R.H., Lerer, B.: Age and the relationship of dopamine D3, serotonin 2C and
serotonin 2A receptor genes to abnormal involuntary movements in chronic
schizophrenia. Molecular Psychiatry 7: 137-139, 2002.

Lerer, B.: Genes and psychopharmacology: Exploring the interface. In: Lerer, B (Editor):
Pharmacogenetics of Psychotropic Drugs. Cambridge University Press, Cambridge,
2002.

Segman, RH, Lerer, B.: Genetic factors underlying drug induced tardive dyskinesia. In:
Lerer, B (Editor): Pharmacogenetics of Psychotropic Drugs. Cambridge University Press,
Cambridge, 2002.

Segman, R.H., Heresco-Levy U., Yakir, A., Goltser, T., Strous, R., Greenberg, D., Lerner,
A., Lerer, B.: Interactive effect of cytochrome P450 17-hydroxylase and dopamine D3
receptor gene polymorphisms on abnormal involuntary movements in chronic
schizophrenia. Biological Psychiatry 51: 261-263, 2002.

Lerer B., Segman, R.H., Fangerau, H., Daly, A.K., Basile, V.S., Cavallaro, R. Aschauer,
H.N., McCreadie, R. G., Ohlraun, S., Ferrier, N., Masellis, M., Verga, M., Scharfetter, J.,
Rietschel , M., Lovlie , R., Heresco Levy, U., Kennedy, J.L., Steen , V.M., Macciardi, F.:
Pharmacogenetics of tardive dyskinesia: Combined analysis of 780 patients supports
association with dopamine D3 receptor gene ser9gly polymorphism.
Neuropsychopharmacology 27: 109-119, 2002.

Lerer, B., Macciardi M.: Pharmacogenetics of antidepressant and mood stabilising drugs:
A review of candidate gene studies and future research directions. International Journal
of Neuropsychopharmacology 5: 255-275, 2002.

Segman, R.H., Goltser, T., Heresco-Levy U., Finkel, B., Strous, R., Shalem, R.,
Schlafman, M., Yakir, A., Greenberg, D., Lerner, A., Shelevoy, A., Lerer, B.: Association
of dopaminergic and serotonergic genes with tardive dyskinesia in patients with chronic
schizophrenia. The Pharmacogenomics Journal (In Press).

Brain Imaging

Bonne, O., Krausz, Y., Lerer, B.: SPECT imaging in psychiatry. General Hospital
Psychiatry. 14: 296-306, 1992.

Krausz, Y., Bonne, O., Marciano, R., Yaffe, S., Lerer, B., Chisin, R.: Brain SPECT
imaging of neuropsychiatric disorders. European Journal of Radiology 21:183-187, 1996.

Bonne, O., Krausz, Y., Shapira, B., Bocher, M., Chisin, R., Lerer, B.: Increased brain Tc-
99m HMPAO uptake in depressed patients who have responded to electroconvulsive
therapy. Journal of Nuclear Medicine 37: 1075-1080, 1996.
Bonne, O., Krausz, Y., Gorfine, M., Karger, H., Gelfin, Y., Chisin, R., Lerer, B.: Cerebral
hypoperfusion in medication resistant depressed patients assessed by Tc-99m HMPAO
SPECT. Journal of Affective Disorders 41:163-171, 1996.

Krausz, Y., Bonne, O., Marciano, R., Gorfine, M., Karger, H., Lerer, B., Chisin, R.: Age-
related changes in brain perfusion of normal subjects detected by Tc-99m-HMPAO
SPECT. Neuro-radiology 40: 428-434, 1998.

Bonne, O., Krausz, Y., Aharon, Y., Gelfin Y., Chisin, R., Lerer, B.: Clinical doses of
fluoxetine and cerebral blood flow in healthy volunteers. Psychopharmacology 143: 24-
28, 1999.

Bonne, O., Louzoun, Y., Aharon, Y., Krausz, Y., Karger, H., Lerer, B., Bocher, M.,
Freedman, N., Chisin, R.: Cerebral blood flow in depressed patients: A methodological
comparison of statistic parametric mapping and region of interest analyses. Psychiatry
Research - Neuroimaging 122: 49-57, 2003

Agid, R., Levin, T., Gomori, J.M., Lerer, B., Bonne, O.: T2-weighted image
hyperintensities in major depression: Focus on the basal ganglia. International Journal of
Neuropsychopharmacology (In Press).

Bonne, O., Gilboa, A., Louzon, Y., Kempf-Sherf, O., Fishman, Y., Ben-Nahum, Z.,
Krausz, Y., Bocher, M., Chisin, R., Lerer, B.: Cerebral blood flow in chronic symptomatic
mild traumatic brain injury. (Submitted).

Psychoneuroimmunology

Morag, M., Yirmiyah, R., Lerer, B., Morag, A.: Influence of socioeconomic status on
behavioral, emotional and cognitive effects of rubella vaccination: A prospective, double
blind study. Psychoneuroendocrinology 23: 337-51, 1998.

Morag, M., Morag, A., Reichenberg, A., Lerer, B., Yirmiyah, R.: Psychological variables
as predictors of rubella antibody titers and fatigue - a prospective, double blind study.
Journal of Psychiatric Research 33:389-95, 1999.

General

Lerer, B.: Biological psychiatry in Israel: Meeting the challenge of maturity (Editorial).
Israel Journal of Psychiatry and Related Sciences 32: 1-4, 1995.

Lerer, B., Segman, R.: Correspondence regarding German psychiatric genetics and
Ernst Rudin. American Journal of Medical Genetics (Neuropsychiatric Genetics) 74: 457-
459, 1997 (Letter).

Lerer, B: In Memoriam: Rachel Alexander: 1940-1996. Israel Journal of Psychiatry and
Related Sciences 33:214, 1996.

Lerer, B., Frazer, A., Stahl, S.M., Farde, L., Lesch, K.P.: The International Journal of
Neuropsychopharmacology. (Editorial) International Journal of
Neuropsychopharmacology 1: 1-2, 1998.

Newman, M.E., Lerer, B.: Receptors and second messengers. In: The New Oxford
Textbook of Psychiatry. (Eds.: Gelder, MG., Lopez Ibor, JJ., Andreasen, NC) Oxford
University Press, Oxford, 2000.
Kohn, Y., Lerer, B.: Methodological advances in psychiatric genetics. In: Soares, J.,
Gershon, S. (Eds.) Handbook of Psychiatry. Marcel Dekker, New York, (In Press).

Journals - Special Issues

Lerer, B. (Guest Editor.): The Neurobiology of ECT Convulsive Therapy - Special Issues
Vol. 14, No. 3, 1998; Vol 15, No. 1, 1999

				
DOCUMENT INFO