Thoroughbred Early Breeding Courtney Blohm, Jessica Laux, Kourtney Kuba Background - The problem Ten thoroughbred breeding mares from prestigious racing farms have been booked to be bred to Whata Studleyman. Whata Studleyman can only do a limited booking since he is training for races in March. The mare owners are interested in producing racing foals they all want their mares bred one week before or after February 15. The stallion owner signed all 10 breeding contracts and now you are legally responsible for breeding the mares within this two week period. The mares will all arrive on January 15 and have been under lights since December 1. The Jockey Club does not allow the use of artificial insemination. The drugs of choice The drugs we will be using will be Regu-Mate, a progesterone, and lutalyse, a prostaglandin The mares are already receiving light treatment. How to get a mare pregnant The Regu-Mate (progesterone) is given once daily for 9-14 days to the mares. The lutalyse (prostaglandin) will be administered the on the same day as the last day of Regu-mate. The mares should come into heat within 2-3 days and ovulate within 5-11 days (avg 8-9 days). Regu-Mate Oral drug progesterone Works on the uterine endometrium, mammary gland, hypothalamus Acts as an agonist, has the same effect as natural progesterone, behaves as a steroid with nuclear receptors Negative feedback on gonadotopin secretion Used to hasten mares through the spring transition in cyclicity Lutalyse Injectible prostaglandin Works on luteal cells Binds to the PGF receptor in the plasma membrane of a luteal cell Has Ca+ second messenger hormone action Initiates regression on the CL Possible Problems The reproductive state of the horse affects the ability of the treatment to work because the horse is a seasonal breeder. The amount of sunlight a mare receives affects her estrus cycle and ovulation. If you give the drug regu-mate during the winter it won't have any effect on the ovulation of the mare. The drug is most effective in the spring or summer when the mares are receiving the needed light to induce their reproductive cycle actions Did it work? To determine if the mare is in estrus, look for teasing behavior when the mare is presented with a stallion. If the treatment regime works, the mare should present signs of estrus, and will have a normal estrus cycle within five to 11 days after the treatment stops. How much time is this going to take? Labor needs will not be high. Someone will need to inject lutalyse and feed regu-mate. Regu-mate will need to be given daily for 9-14 days and lutalyse on a one-time basis, and this will not be very labor intensive with ten horses. At parturition, it will be the owners' of the female horses responsibility to monitor the pregnancy and birth of the foal.
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