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									                         CONTINUING EDUCATION COURSE MATRIX 1990 - 2005
Class                    Topic                                        Year
                                                               Count of Topic#
                                                               Topic# 1990 1991     1992   1993   1994   1995   1996   1997   1998   1999   2000   2001   2002   2003   2004   2005 Grand Total
Target Organs            Cardiovascular                             1        1                                                                 1                                  2           4
Target Organs            Endocrine System (Disrupters)              2                                       1                                                              1                  2
Target Organs            Gastrointestinal                           3                                                            1                                                            1
Target Organs            Hematology                                 4        1                                                                               1                                2
Target Organs            Immune System                              5           1             1      1                    1             1      1      1             1             1           9
Target Organs            Kidney                                     6                  1                                  1                                                       1           3
Target Organs            Liver                                      7        2         2                    1                                         1                                       6
Target Organs            Nervous System                             8           1             1      1                           1             1                           1                  6
Target Organs            Reproductive                               9           1                                  1      1             1                           1      1      1           7
Target Organs            Respiratory                               10        1                       1                                  1                                                     3
Target Organs            Skin                                      11                                                            1                                  1      1                  3
Target Organs            Eye                                       13                                                                                 1                                       1
Developmental Toxicity   Developmental Toxicity                    15        1         1                    1                    1      1                                         1           6
Carcinogenesis           Carcinogenesis                            16                                       1                                  1                    1                         3
Metabolism               Metabolism                                17        1                                     1                                                                          2
Pharmacokinetics-PBPK    Pharmacokinetics-PBPK                     18                                1             1                           1             1      1                         5
Agents                   Biotech Products                          21                  1                                                                                                      1
Agents                   Foods                                     22                                                     1                           1                                       2
Agents                   Halogenated Compounds                     24                  1                                                                                                      1
Agents                   Metals                                    25           1                                         1             1      1      1                                       5
Agents                   Naturally-Occurring                       26           1                                                                            1      1      1                  4
Agents                   Non-Genotoxic Carcinogens                 27                         1                                                1                                              2
Agents                   Pesticides                                28        1                1                                                                                               2
Methods/Mechanisms       Phototocity                               32                                                                          1                                  1           2
Methods/Mechanisms       Cell Biology                              33        2                                     1                                                       2                  5
Methods/Mechanisms       Cell Death                                34                         1                    1             1      1             1      1                                6
Methods/Mechanisms       Cell Proliferation/Signal Transduction    35                  1                           1      1      1                                                            4
Methods/Mechanisms       Cytokines                                 37                                       1                    1                                                            2
Methods/Mechanisms       Gene Expression                           38                         1      1      1                           1                    1                                5
Methods/Mechanisms       Genetic Toxicology                        39                                1                    1                           1      1      1                         5
Methods/Mechanisms       Genomics/Proteiomics                      40                                                     1             2      2      2      2      1      3                 13
Methods/Mechanisms       Inhalation Methods                        41           1                                         1                                                                   2
Methods/Mechanisms       In Vitro Methods                          42                                1      1                    1      1             1             1             1           7
Methods/Mechanisms       Molecular Biology (techniques)            43           2             1      1      1      1      1      2      2      3      1      3      2                        20
Methods/Mechanisms       Mitochondrial                             44                                              1                                                                          1
Methods/Mechanisms       Molecular Biomarkers                      45                         1      1                                                1                                       3
Methods/Mechanisms       Receptors, Steroid                        47                                              1      1                                                                   2
Applied/Other            Saftey Pharmacology                       50                                                                          1                           1                  2
Applied/Other            Epidemiology                              51                                              1      1                    1                                              3
Applied/Other            Environmental Tox                         52           1                           1      1                    1             1                                       5
Applied/Other            Modeling                                  53           2      1                                                1                                  1                  5
Applied/Other            Regulatory/Harmonization                  54                                2                           1                           1             1      2           7
Applied/Other            Risk Assessment                           55        2         1      2             2      1      1      2             1      2      1      2                        17
Applied/Other            Risk Communication                        56           2                                                1             1                                              4
Applied/Other            Drug Development                          57                                                                                        2                    1           3
Applied/Other            Occupational Toxicology                   58                                                                                 1                                       1
Applied/Other            Nanotechnology                            61                                                                                                             1           1
Methods/Mechanisms       Clinical Pathology                        48                                                                                                             1           1
                                                               Grand Total 12  13      9     10     11     11     12     13     14     14     17     16     15     13     13     13        206
                                                                                                    Course Matrix Thru 2004



Year Time   #      Title                              B/A   Endorsed by               Endorsed by               Endorsed by              REG   Topic                    Topic# Chair                 Co-Chair
 2005 SR         1 Fundamentals of                    B     Ethical, Legal and Social Inhalation Specialty      Occupational and Public        Regulatory/Harmonization       61 David B. Warheit
                   Nanotechnology: Chemistry,               Issues                    Section*                  Health Specialty Section
                   Exposure,
                   Health/Environmental
                   Assessments and Societal
                   Impacts
 2005 AM         2 Dose Considerations for In         B     In Vitro Specialty Section Inhalation Specialty     Risk Assessment                In Vitro Methods               42 John B. Morris      JeanClare
                   Vitro Studies of Air Pollutant                                      Section*                 Specialty Section                                                                    Seagrave
                   Toxicity
 2005 AM         3 Developmental Toxicology           B     Reprodutive and           Risk Assessment                                          Developmental Toxicity         15 Joseph H. Holson    Ronald D. Hood
                   Studies: Design, Interpretation,         Developmental
                   and Risk Assessment                      Toxicology Specialty
                                                            Section*
 2005 AM         4 Clinical Biomarkers: The           B     Comparative and           Toxicologic &             Risk Assessment                Clinical Pathology             48 Thomas Monticello Gail Walter
                   Granddaddy of Biomarkers                 Veterinary Specialty      Exploratory Pathology     Specialty Section
                                                            Section                   Specialty Section*
 2005 AM         5 Immunology for Toxicologists       B     Immunotoxicology          Risk Assessment                                          Immune System                   5 Ian Kimber          Dori R. Germolec
                                                            Specialty Section*        Specialty Section
 2005 AM         6 Evaluation of Cardiac Drug     B         Comparative and           Mechanisms Specialty      Regulatory and Safety          Cardiovascular                  1 Brian Short         Y. J. Kang
                   Toxicity in Pharmaceutical               Veterinary Specialty      Section                   Evaluation Specialty
                   Discovery and Development                Section                                             Section
 2005 AM         7 International Harmonization of B         Carcinogenesis            Regulatory & Safety       Risk Assessment                Regulatory/Harmonization       54 Rakesh Dixit
                   Technical Requirements for               Specialty Section*        Evaluation Specialty      Specialty Section
                   Conducting Non-Clinical Safety                                     Section
                   Studies of Human
                   Pharmaceuticals: Guidelines,
                   Case Studies, and Challenges

 2005 PM         8 Male Reproductive Hazard       A         Reproductive and          Regulatory & Safety       Toxicologic &                  Reproductive                    9 Michael W. Conner Robert E. Chapin
                   Identification and Risk                  Developmental             Evaluation Specialty      Exploratory Pathology
                   Assessment in Pharmaceutical             Toxicology Specialty      Section                   Specialty Section
                   Development (What Do You                 Section*
                   Do Now That You Have a
                   Signal?)
 2005 PM         9 Development and Interpretation A         Regulatory and Safety     Risk Assessment                                          Drug Development               57 John Lipscomb       Jos Bessems
                   of Toxicokinetic Data for Risk           Evaluation Specialty      Specialty Section*
                   and Safety Assessment                    Section

 2005 PM        10 Phototoxicity: Current             B     Regulatory and Safety     Risk Assessment                                          Phototoxicity                  32 Joseph Tigner       Vincent A. Murphy
                   Concepts, Experimental                   Evaluation Specialty      Specialty Section
                   Designs, and Regulatory                  Section*
                   Expectations
 2005 PM        11 Something Old, Something           B     Risk Assessment           Toxicologic &                                            Kidney                          6 Susan Emeigh Hart Syril Pettit
                   New: Traditional and Novel               Specialty Section         Exploratory Pathology
                   Biomarkers of Renal Injury                                         Specialty Section*
 2005 PM        12 Evaluation of Cardiac Drug         B     Comparative and           Mechanisms Specialty      Regulatory and Safety          Cardiovascular                  1 Brian Short         Y. J. Kang
                   Toxicity in Pharmaceutical               Veterinary Specialty      Section                   Evaluation Specialty
                   Discovery and Development                Section                                             Section
 2005 PM        13 International Harmonization of     B     Carcinogenesis            Regulatory & Safety       Risk Assessment                Regulatory/Harmonization       54 Rakesh Dixit
                   Technical Requirements for               Specialty Section*        Evaluation Specialty      Specialty Section
                   Conducting Non-Clinical Safety                                     Section
                   Studies of Human
                   Pharmaceuticals: Guidelines,
                   Case Studies, and Challenges




       2
                                                                                                     Course Matrix Thru 2004



Year   Time   #      Title                               B/A   Endorsed by               Endorsed by              Endorsed by             REG   Topic                      Topic#      Chair               Co-Chair
                     Herbals and Dietary
                     Supplements in Athletic
                     Performance Enhancement:
 2004 SR           1 Fact vs. Fiction                    SR                                                                                     Naturally-Occurring                 26 Alfred Fuciarelli
                                                               Mechanisms Specialty                               Neurotoxicology                                                      Evelyn Tiffany-
 2004 AM           2 Basic Neurotoxicology               B     Section                   Metals Specialty Section Specialty Section*            Nervous System                       8 Castiglioni         William Slikker, Jr.
                     Tools for Functional Genomics             Molecular Biology
 2004 AM           3 (PM10 Repeated)                     A     Specialty Section*                                                               Genomics/Proteiomics                40 Hollie Swanson
                     Of Mice and Magnets:
                     Metabonomics Technology in                Molecular Biology         Risk Assessment                                                                                                   Lois D. Lehman-
 2004 AM           4 Safety Assessment                   B     Specialty Section*        Specialty Section                                      Genomics/Proteiomics                40 Donald Robertson    McKeeman
                     Functional Flow Cytometry:
                     Applications in Toxicology                Immunotoxicology                                                                                                        Leigh Ann Burns
 2004 AM           5 (PM12 Repeated)                     A     Specialty Section*                                                               Cell Biology                        33 Naas                Nancy Kerkvliet
                     Understanding Lifespan
                     Changes in Form and Function
                     of the Female Reproductive                Reproductive and
                     System to Assess and Interpret            Developmental Specialty
 2004 AM           6 Toxicity                            B     Section                                                                          Reproductive                         9 Lewis Kinter        Barbara J. Davis
                     The Safety Assessment of                                            Regulatory and Safety
                     Proteins: Applications to                 Food Safety Specialty     Evaluation Specialty     Risk Assessment
 2004 AM           7 Agricultural Biotechnology          B     Section*                  Section                  Specialty Section             Regulatory/Harmonization            54 G. Frank Gerberick Bruce G. Hammond

                                                               Comparative and           Regulatory and Safety
                       Safety Pharmacology After ICH           Veterinary Specialty      Evaluation Specialty
 2004 PM           8   S7A & S7B                         B     Section*                  Section                                                Saftey Pharmacology                 50 Lewis Kinter        Alan Bass
                       Skin Sensitization and Allergic         Dermal Toxicology         Immunotoxicology
 2004 PM           9   Contact Dermatitis                B     Specialty Section*        Specialty Section                                      Skin                                11 G. Frank Gerberick Ian Kimber
                       Tools for Functional Genomics           Molecular Biology
 2004 PM          10   (AM03 Repeated)                   A     Specialty Section*                                                               Genomics/Proteiomics                40 Hollie I. Swanson
                       Computational Biology, Dose &           Biological Modeling
 2004 PM          11   Response                          A     Specialty Section*                                                               Modeling                            53 Melvin E. Andersen Jeffrey W. Fisher
                       Functional Flow Cytometry:
                       Applications in Toxicology              Immunotoxicology
 2004 PM          12   (PM12 Repeated)                   A     Specialty Section                                                                Cell Biology                        33 Leign Burns Naas    Nancy Kerkvliet
                                                                                        Regulatory and Safety     Toxicologic &
                     Adnrenal Gland: Mechanisms                Carcinogenesis Specialty Evaluation Specialty      Exploratory Pathology
 2004 PM          13 of Toxicity and Carcinogenesis B          Section*                 Section                   Specialty Section             Modeling                             2 Jon C. Cook

 2003 SR           1 Computational Biology, Dose & A           Molecular Biology                                                           193 Molecular Biology                    43 Julio Davila
                     Response                                  Specialty Section                                                               (techniques)
 2003 AM           2 Functional Flow Cytometry:    A           Molecular Biology                                                           121 Molecular Biology                    43 William Mattes
                     Applications in Toxicology                Specialty Section                                                               (techniques)
                     (AM05 Repeated)
 2003 AM           3 Functional Flow Cytometry:    A           In Vitro Specialty Section Neurotoxicology                                   74 In Vitro Methods                     42 Timothy Shafer      Wei Zheng
                     Applications in Toxicology                                           Specialty Section,
                     (AM05 Repeated)                                                      Mechanisms Sepcialty
                                                                                          Section
 2003 AM           4 Adrenal Gland: Mechanisms of B            Comparative and            Toxicologic and                                  120 Genetic Toxicology                   39 Wanda Haschek-      Jeff Everitt
                     Toxicity and Carcinogenesis               Veterinary Specialty       Exploratory Pathology                                                                        Hock
                                                               Section                    Specialty Section
 2003 AM           5 Fundamentals of Risk                B     Risk Assessment            Biological Modeling                              278 Risk Assessment                      55 Dennis
                     Assessment and Applications               Specialty Section          Specialty Section,                                                                           Paustenbach
                     of Recent Methodologies to                                           Carcinogenesis, Food
                     Difficult Problems                                                   Safety



         3
                                                                                                Course Matrix Thru 2004



Year Time   #      Title                           B/A   Endorsed by               Endorsed by                Endorsed by   REG Topic                     Topic#      Chair               Co-Chair
 2003 AM         6 Cutaneous Toxicity - Current    B     Regulatory and Safety     Dermal Toxicology, In                      206 Skin                             11 Nancy Monteiro-     Carol Auletta
                   Methods and Concepts in               Evaluation Specialty      Vitro Specialty Sections                                                           Riviere
                   Safety Evaluation: Relevance          Section
                   to Human Exposure
 2003 AM         7 Medicinal Herbals and Dietary   A     Food Safety Specialty      Regulatory & Safety                       196 Naturally-Occurring              26 Alfred Fuciarelli   William Allaben
                   Supplements                           Section                    Evaluation Specialty
                                                                                    Section
 2003 PM         8 Genomic and Proteomic Array A         In Vitro Specialty Section Mechanisms and                            186 Genomics/Proteiomics             40 Mary Jane
                   Formats on the Cutting-Edge                                      Molecular Biology                                                                 Cunningham
                                                                                    Specialty Sections
 2003 PM         9 Integrating Toxicologic         B     Toxicologic and            Comparative and                           156 Risk Assessment                  55 Douglas Wolf
                   Pathology into Compound               Exploratory Pathology      Veterinary Specialty
                   Evaluation and Risk                   Specialty Section          Section
                   Assessment II
 2003 PM        10 Choice and Application of       A     Biological Modeling       Regulatory & Safety                        153 Pharmacokinetics-PBPK            18 John Lipscomb       Rakesh Dixit
                   Classical, Population, or             Specialty Section         Evaluation and Risk
                   Physiologically-Based PK for                                    Assessment Specialty
                   Chemical Assessment and                                         Sections
                   Pharmaceutical Development
 2003 PM        11 Evaluation of                   B     Immunotoxicology                                                     234 Immune System                     5 Dori Germolec       Robert House
                   Immunomodulation in Safety            Specialty Section
                   Assessment
 2003 PM        12 The Effects of Non-             A     Reproductive &                                                       177 Reproductive                      9 Robert Chapin       Kimberley Treinen
                   Reproductive Hormones on the          Developmental Specialty
                   Reproductive System                   Section
 2003 PM        13 Epigenetics of Cancer           B     Carcinogenesis                                                       143 Carcinogenesis                   16 Ruth Roberts        Jay Goodman
                                                         Specialty Section
 2003              TOTAL                                                                                                    2237
 2002 SR         1 Sunrise Mini Course: Use of   B       Molecular Biology         Toxicologic and                           136 Molecular Biology                 43
                   Laser Capture Microdissection         Specialty Section         Exploratory Pathology                         (techniques)
                   (LCM) in Molecular Toxicology                                   Specialty Section
                   Research

 2002 AM         2 A Practical Approach to Blood   B     Toxicologic and                                                      156 Hematology                        4 JoAnn C.L. Schuh    Lynda Lanning
                   and Lymphoid Tissue (BLT) in          Exploratory Pathology
                   Toxicology Assessments                Specialty Section

 2002 AM         3 Alterations in Gene Expression A      Molecular Biology         Regulatory and Safety                      209 Gene Expression                  38 Ronald Hines
                   as a Mechanism of Toxicant            Specialty Section        Evaluation Specialty
                   Action                                                         Section Reproductive
                                                                                  and Developmental
                                                                                  Specialty Section
 2002 AM         4 Integrating Toxicologic         B     Comparative and          Toxicologic and                             188 Risk Assessment                  55 Douglas Wolf        Jerry F. Hardisty
                   Pathology into Compound               Veterinary Specialty     Exploratory Pathology
                   Evaluation and Risk                   Section, Regulatory and Specialty Section
                   Assessment                            Safety Specialty Section

 2002 AM         5 Basic Principles and Protocols B      Molecular Biology                                                     79 Molecular Biology                43 William Mattes      John Davis
                   in Molecular Toxicology               Specialty Section                                                        (techniques)

 2002 AM         6 Two-Stepping through            B     In Vitro Specialty Section Risk Assessment                           173 Genomics/Proteiomics             40 Mary Jane           Timothy
                   Toxicogenomics: A Basic                                          Specialty Section and                                                             Cunningham          Zacharewski
                   Primer                                                           Mechanisms Specialty
                                                                                    Section
 2002 AM         7 Challenges in Development of    B     Comparative and            Regulatory and Safety                     161 Drug Development                 57 Vijayapal Reddy     Adaline Smith
                   Anticancer Drugs                      Veterinary Specialty       Evaluation Specialty
                                                         Section                    Section
       4
                                                                                                  Course Matrix Thru 2004



Year Time   #      Title                         B/A     Endorsed by                  Endorsed by                Endorsed by   REG Topic                        Topic#      Chair               Co-Chair
 2002 AM         8 Incorporation of              A       Biological Modeling          In Vitro Specialty Section                 185 Pharmacokinetics-PBPK               18 John Lipscomb       Lynne Haber
                   Pharmacokinetic and                   Specialty Section            and Risk Assessment
                   Pharmacodynamic Data into                                          Specialty Section
                   Risk Assessments
 2002 PM         9 Toxicology of Naturally       B       Comparative and              Toxicologic and                            166 Naturally-Occurring                 26 Frederick Oehme     Robert Coppock
                   Occurring Toxins - Don’t Mess         Veterinary Specialty         Exploratory Pathology
                   with Mother Nature!                   Section, Food Safety         Specialty Section
                                                         Specialty Section
 2002 PM        10 Regulation of Drug and       A        Molecular Biology                                                       108 Cell Death                          34 Sid Ray             Stephen Pruett
                   Chemically-Induced Apoptotic          Specialty Section
                   Cell Death: New In Vivo
                   Perspectives
 2002 PM        11 Internal Dosimetry:          A        Carcinogenesis               Epidemiology Specialty                      66 Genetic Toxicology                  39 Barbara Shane
                   Measurement of DNA Damage             Specialty Section            Section and the
                   as an Indicator of Internal                                        Environmental Mutagen
                   Exposure to Genotoxicants                                          Society

 2002 PM        12 Toxicity Profiling of Genes and A     Toxicologic and              Mechanisms Specialty                       281 Genomics/Proteiomics                40 Alex Merrick        Darlene Dixon
                   Proteins by Toxicologists:            Exploratory Pathology        Section
                   Advanced Topics in                    Specialty Section
                   Toxicogenomics
 2002 PM        13 Basic Principles and Protocols B      Molecular Biology                                                       146 Molecular Biology                   43 William Mattes      John Davis
                   in Molecular Toxicology               Specialty Section                                                           (techniques)

 2002 PM        14 Strategies and Issues in Non-   B     Regulatory and Safety        Reproductive and                           144 Drug Development                    57 William Halliwell   George Lulham
                   Clinical Development of               Evaluation Specialty         Developmental Specialty
                   Intravenous Infusion Drug             Section                      Section
                   Products
 2002 PM        15 Current Approaches for          B     In Vitro Specialty Section                                              102 Regulatory/Harmonization            54 Sidney Green
                   Validation and Regulatory
                   Acceptance of Novel Test
                   Methods
 2002              TOTAL                                                                                                        2300
 2001 AM         1 Sunrise Mini-Course:            B     None listed                                                             358 Genomics/Proteiomics                40
                   GenomicTechnologies Applied
                   to Toxicology
 2001 AM         2 Web Resources for               B     Regulatory and Safety        Occupational Health                        188 Occupational Toxicology             58 Philip Wexler
                   Toxicologists                         Evaluation Specialty         Specialty Section
                                                         Section
 2001 AM         3 Ocular Toxicity: Assessment     B     Comparative and              Toxicologic and                            147 Eye                                 13 Michael Biehl       Donald Fox
                   Methods and Mechanisms                Veterinary Specialty         Exploratory Pathology
                                                         Section                      Specialty Section
 2001 AM         4 Risk Assessment for Metals      A     Risk Assessment Task         Risk Assessment                            132 Risk Assessment                     55 Barbara Beck        Charles Abernathy
                                                         Force                        Specialty Section,
                                                                                      Metals Speciatly Section

 2001 AM         5 Choosing Tools for              Baisc Molecular Biology                                                       260 Genomics/Proteiomics                40 Diane Heck          Mark Carfaga
                   Toxicogenomics: A Primer for          Specialty Section
                   the Research Scientist
 2001 AM         6 Liver Toxicology                B     Mechanisms Specialty                                                    288 Liver                                7 Mark Carfagna
                                                         Section
 2001 AM         7 Nutraceuticals/Functional       B     Food Safety Specialty        Regulatory and Safety                      151 Foods                               22 Carol Auletta       Joseph Tigner
                   Foods--Safety and Regulatory          Section                      Evaluation Specialty
                   Issues                                                             Section




       5
                                                                                                Course Matrix Thru 2004



Year Time   #      Title                           B/A   Endorsed by              Endorsed by                 Endorsed by   REG Topic                    Topic#      Chair              Co-Chair
 2001 AM         8 Receptors and Signal            B     Society of Environmental                                              76 Environmental Tox               52 Mark Hahn          Richard Pollenz
                   Transduction in Ecotoxicology         Toxicology and
                                                         Chemistry

 2001 PM         9 Novel In Vivo Genotoxicity      B     Environmental Mutagen Molecular Biology                              127 Genetic Toxicology              39 Barbara Shane      William Mattes
                   Assays: Developing Trends for         Society                  Specialty Section,
                   Pharmaceutical and                                             Carcinogenesis
                   Environmental Applications                                     Specialty Section
 2001 PM        10 Neurotoxicology of Meals:       B     Metals Specialty Section Neurotoxicology                              90 Metals                          25 Peter Goering      Wei Zheng
                   Causes and Consequences                                        Specialty Section
 2001 PM        11 Development and Use of          A     Molecular Biology                                                    197 Molecular Biology               43 Christopher        Bhagavatula
                   Transgenic Animal Models in           Specialty Section                                                        (techniques)                       Bradfield          Moorthy
                   Toxicology
 2001 PM        12 Food Allergy and Intolerance    B      Immunotoxicology          Food Safety Specialty                     101 Immune System                    5 Ian Kimber         Lois Kotkoskie
                                                          Specialty Section         Section
 2001 PM        13   Environmental Bioindicators:   Baisc Immunotoxicology                                                     70 Molecular Biomarkers            45 Judith Zelikoff    Peter Thomas
                     Useful Tools for Assessing At-       Specialty Section
                     Rish Populations
 2001 PM        14   Prediction of Human Toxicity   B     In Vitro Specialty                                                  234 In Vitro Methods                42 Albert Li          Gregory Kedderis
                     and Metabloic Fate of Drugs          Section
                     Using In Vitro Systems
 2001 PM        15   Stress Kinases, NF-kB and      A     Molecular Biology                                                   188 Cell Death                      34 Tony Kong          Colin Jefcoate
                     Caspases: Pathways in                Specialty Section
                     Chemical-Induced Cell Sruvival
                     and Death
 2001 PM        16   Improving Risk Assessment for B      Reproductive and          Risk Assessment                           173 Risk Assessment                 55 Elaine Faustman    Abigail Stack
                     Human Developmental                  Developmental Specialty   Specialty Section, Risk
                     Defects: The Promise of              Section                   Assessment Task Force
                     Recent Advances in
                     Development Biology and
                     Genomics
 2001                TOTAL                                                                                                   2780
 2000 SR         1   Introduction to Proteomics     B     Mechanisms Specialty                                                214 Genomics/Proteiomics            40 Daniel Liebler
                                                          Section
 2000 SR         2   Metabonomics - A New           B     Mechanisms Specialty                                                 82 Molecular Biology               43 Donald Robertson
                     Approach to Drug Toxicity            Section                                                                 (techniques)
                     Screening using NMR
                     Spectroscopy, Pattern
                     Recognition, and Expert
                     Systems
 2000 AM         3   Environmental Epidemiology     B     Epidemiology Specialty                                              127 Epidemiology                    51 Richard Parent     Christopher
                     and Toxicology: The Interface        Section                                                                                                                       Schonwalder
                     and the Interactions
 2000 AM         4   Pulmonary Immunotoxicology B         Immunotoxicology          Inhalation Specialty                      149 Immune System                    5 Mitchell Cohen     Judith Zelikoff
                                                          Specialty Section         Section
 2000 AM         5   Molecular Genetics,            B     Carcinogenesis                                                       49 Carcinogenesis                  16 Myrtle Davis
                     Metabolism, and Cell Signaling       Specialty Section
                     in Renal Carcinogenesis: A
                     Lesson in Synergistic
                     Toxicology
 2000 AM         6   Molecular Approaches to a      B     Mechanisms Specialty      Molecular Biology                         118 Cardiovascular                   1 Y. James Kang
                     Comprehensive Understanding          Section,                  Specialty Section
                     of Cardiotoxicity




       6
                                                                                                 Course Matrix Thru 2004



Year Time   #      Title                        B/A     Endorsed by                  Endorsed by                Endorsed by   REG Topic                     Topic#      Chair              Co-Chair
 2000 AM         7 Advanced Neurotoxicology:    A       Neurotoxicology                                                         135 Nervous System                    8 William Slikker    Thomas Guilarte
                   Biomarkers and Mechanisms            Specialty Section
                   of Oxidative Stress Induced
                   Neurotoxicity
 2000 AM         8 Rodent Toxicity and          B       Mechanisms Specialty         Risk Assessment                            273 Non-Genotoxic                    27 Ruth Roberts       William Farland
                   Nongenotoxic Carcinogenesis:         Section                      Specialty Section                              Carcinogens
                   Knowledge-based Human Risk
                   Assessment from Molecular
                   Mechanisms

 2000 AM         9 Advances in Non-invasive     B       Molecular Biology                                                        62 Molecular Biology                43 Robert Burghardt   Martin Philbert
                   Micrometer and Nanometer             Specialty Section                                                           (techniques)
                   Scale Cellular/Tissue Vital
                   Imaging
 2000 AM        10 Tips for Effective Risk      B       RALA                         CPC, RASS                                   90 Risk Communication               56 Mary Jo Miller     George Gray
                   Communication
 2000 PM        11 Use of Antibody Reagents to  B       Molecular Biology                                                       114 Molecular Biology                43 Richard Pollenz
                   Evaluate Toxicant-Mediated           Specialty Section                                                           (techniques)
                   Signal Transduction Pathways

 2000 PM        12 Phototoxicology: Basic           B   None                                                                    106 Phototocity                      32 P. Donald Forbes   Paul Howard
                   Principles of Light,
                   Photobiology, and Regulatory
                   Issues
 2000 PM        13 Toxicokinetics and               B   None                                                                    230 Pharmacokinetics-PBPK            18 Rakesh Dixit
                   Physiologically Based
                   Toxicokinetics in Toxicology
                   and Risk Assessment
 2000 PM        14 Metal Exposure and Toxicity of   A   Inhalation Specialty         Metals Specialty Section                    87 Metals                           25 Daniel Morgan      Michael Waalkes
                   the Respiratory Tract                Section
 2000 PM        15 Safety Pharmacology and Risk     B   Comparative &                Regulatory & Safety                        231 Saftey Pharmacology              50 Lewis Kinter       Alan Bass
                   Assessment                           Veterinary Specialty         Evaluation Specialty
                                                        Section,                     Section
 2000 PM        16 Toxicogenomics in the            B   Molecular Biology                                                       242 Genomics/Proteiomics             40 Tim Zacharewski
                   Trenches                             Specialty Section
 2000 PM        17 The Application of Philosophy    B   SETAC                                                                    94 Risk Assessment                  55 Marc Saner
                   to Risk Assessment,
                   Management, and
                   Communication
 2000              TOTAL                                                                                                       2403
 1999 SR           Basic Bioinformatics: From       B   Molecular Biology                                                       267 Genomics/Proteiomics             40 William Mattes
                   Sequence Analysis to Genome          Specialty Section
                   Analysis
 1999 AM         1 Evaluation of Male               B   Reproductive &                                                          183 Reproductive                      9 Marion Miller      Lori Dostal
                   Reproductive Toxicity: Sperm         Developmental Specialty
                   Markers and Epididymal               Section
                   Mechanisms of Toxicity

 1999 AM         2 Application of Transgenic       A    Molecular Biology                                                       278 Molecular Biology                43 Raymond Tennant
                   Models in Toxicology                 Specialty Section                                                           (techniques)
 1999 AM         3 Gene Regulation by Reactive A        Molecular Biology                                                       223 Gene Expression                  38 Alvaro Puga
                   Oxygen Species                       Specialty Section
 1999 AM         4 In Vitro Methods for Evaluating B    In Vitro Specialty Section                                              141 In Vitro Methods                 42 John Frazier
                   Biokinetic Parameters for Risk
                   Assessment



       7
                                                                                                 Course Matrix Thru 2004



Year Time   #      Title                             B/A   Endorsed by              Endorsed by                 Endorsed by   REG Topic                         Topic#      Chair              Co-Chair
 1999 AM         5 Advanced Metal Toxicology         A     Metals Specialty Section                                             106 Metals                               25 Michael Waalkes

 1999 AM         6 Chemical Hypersensitivity         B     Immunotoxicology                                                     209 Immune System                         5 Meryl Karol        Jacques Decotes
                                                           Specialty Section
 1999 PM         7 Techniques for Detection and      B     Molecular Biology                                                    126 Cell Death                           34 Rick Schnellmann
                   Quantification of Apoptosis             Specialty Section
 1999 PM         8 Genomic Technologies and          A     Molecular Biology                                                    275 Genomics/Proteiomics                 40 Irwin Rosenblum    Roger Ulrich
                   New Screening Strategies for            Specialty Section
                   Toxicology
 1999 PM         9 Gene Targeting/Null Models In           Molecular Biology                                                    104 Molecular Biology                    43 Christopher
                   Toxicology                              Specialty Section                                                        (techniques)                            Bradfield
 1999 PM        10 The Practice of Structure         A     Molecular Biology                                                    152 Modeling                             53 James McKinney
                   Activity Relationships (SAR) in         Specialty Section
                   Toxicology
 1999 PM        11 Target Organ Toxicology:          B     Inhalation Specialty                                                 175 Respiratory                          10 John Morris
                   Respiratory Tract Dosimetry &           Section
                   Response to Inhaled Toxicants

 1999 PM        12 The EDSTAC Tier 1 Screening B           Reproductive &                                                       212 Developmental Toxicity               15 L'Earl Gray, Jr.   John Cook
                   Battery: Objectives and                 Developmental Specialty
                   Recommended Assays                      Section

 1999 PM        13 Basics of Ecological Risk         B     SETAC                                                                 81 Environmental Tox                    52 Angela Schmidt
                   Assessment
 1999              TOTAL                                                                                                       2532
 1998 AM         1 Protein-Protein and DNA-          A     Molecular Biology                                                    115 Molecular Biology                    43
                   Protein Interactions:                   Specialty Section                                                        (techniques)
                   Implications and Uses in
                   Toxicology
 1998 AM         2 Uncertainty Analysis in           B     None                                                                 176 Risk Assessment                      55
                   Toxicology and Risk
                   Assessment
 1998 AM         3 Cytokines as Indicators of        A     Immunotoxicology                                                     231 Cytokines                            37
                   Toxicity: The Immune System             Specialty Section
                   and Beyond
 1998 AM         4 Measurements of Oxidative         A     None                                                                 161 Molecular Biology                    43
                   Stress                                                                                                           (techniques)
 1998 AM         5 Methods for Assessment of         A     Neurotoxicology                                                      130 Nervous System                        8
                   Neurotoxicity                           Specialty Section
 1998 AM         6 International Harmonization of    B     Carcinogenesis                                                       239 Regulatory/Harmonization             54
                   Non-clinical Toxicology:                Specialty Section
                   Regulations vs. Practice
 1998 AM         7 Small Intestinal Responses to     B     None                                                                  32 Gastrointestinal                      3
                   NSAIDs and Other Insults
 1998 PM         8 Cellular and Molecular            A     Mechanism Specialty                                                  178 Cell Death                           34
                   Pathways in Apoptosis and               Section
                   Necrosis
 1998 PM         9 Methods in Cell Signaling         B     Molecular Biology                                                    135 Cell Proliferation/Signal            35
                                                           Specialty Section                                                        Transduction
 1998 PM        10 Effective Risk Communication: B         Risk Assessment           Task Force ISB RA,                         111 Risk Communication                   56
                   Avoiding the Pitfalls                   Specialty Section         CPC

 1998 PM        11 Integration of Mechanistic,       B     Veterinary                Toxicologic Pathologists                   321 Risk Assessment                      55
                   Pathologic and Toxicokinetic                                      Specialty Section
                   Data in Safety Assessment



       8
                                                                                                      Course Matrix Thru 2004



Year Time     #    Title                              B/A   Endorsed by                Endorsed by                Endorsed by   REG Topic                         Topic#        Chair   Co-Chair
 1998 PM        12 In Vitro and In Vivo               B     In Vitro Specialty Section Veterinary Specialty                        99 Skin                                 11
                   Assessment of Cutaneous                                             Section
                   Toxicity
 1998 PM        13 Current Developmental              A     Reproductive &                                                        106 Developmental Toxicity               15
                   Biology: Relevance and                   Developmental Specialty
                   Applications for Toxicology              Section
 1998 PM        14 Emerging In Vitro Toxicology       A     In Vitro Specialty Section                                            147 In Vitro Methods                     42
                   Testing Methods
 1998              TOTAL                                                                                                         2181
 1997 AM/PM   1,8 Use of the Benchmark Dose in        B     Risk Assessment              Mechanisms Specialty                     202 Risk Assessment                      55
                   Risk Assessment                          Specialty Section            Section
 1997 AM         2 Endocrine Control of               B     Reproductive &                                                        181 Reproductive                         9
                   Reproductive Development –               Development Specialty
                   Normal and Abnormal Aspect               Section
 1997 AM         3 Toxicology of Agents: Metals       B     Metal Specialty Section                                                54 Metals                               25

 1997 AM           4 The Role of Toxicology in              Food Safety Specialty        Regulatory & Safety                       38 Foods                                22
                     Ensuring the Safety of New             Section                      Evaluation Specialty
                     Food Technologies and                                               Section
                     Practices
 1997 AM           5 Epidemiology for Toxicologists         Regulatory & Safety                                                    93 Epidemiology                         51
                     II, Methodology                        Evaluation Specialty
                                                            Section
 1997 AM           6 Techniques for Determining       A     Molecular Biology            Mechanisms Specialty                      30 Genomics/Proteiomics                 40
                     Genetic Polymorphism                   Specialty Section            Section
 1997 AM           7 Cell Signaling in Toxicology     A     Molecular Biology                                                     173 Cell Proliferation/Signal            35
                                                            Specialty Section                                                         Transduction
 1997 PM           9 Neuroimmunology: Implications A        Immunotoxicology             Neurotoxicology                           91 Immune System                        5
                     for Toxicology                         Specialty Section            Specialty Section,
                                                                                         Mechanisms Sepcialty
                                                                                         Section
 1997 PM          10 Making Sense of Antisense        A     Molecular Biology                                                      65 Molecular Biology                    43
                                                            Specialty Section                                                         (techniques)
 1997 PM        11 Methods for Assessing                    Molecular Biology                                                     109 Receptors, Steroid                   47
                   Chemical Interaction with the            Specialty Section
                   Estrogen Receptor
 1997 PM        12 Molecular Basis of Genotoxicity          Molecular Biology            Carcinogenesis                           109 Genetic Toxicology                   39
                   Assays                                   Specialty Section            Specialty Section
 1997 PM        13 Nephrotoxicity: Basic              B/A   Mechanisms Specialty                                                   67 Kidney                               6
                   Mechanisms and Recent                    Section
                   Advances
 1997 PM        14 Unique Problems Associated         B     Comparative &                Inhalation Specialty                      95 Inhalation Methods                   41
                   with the Use of Animals in               Veterinary Specialty         Section
                   Inhalation Toxicology                    Section
 1997              TOTAL                                                                                                         1307
 1996 AM/PM   1,8 Advanced Topics in                  A                                                                           204 Pharmacokinetics-PBPK                18
                   Toxicokinetics
 1996 AM/PM   2,9 Apoptosis: Recent Advances          A                                                                            98 Cell Death                           34
                   in Detection and Regulation
 1996 AM         3 Toxicant Effects Mediated by       B                                                                           165 Receptors, Steroid                   47
                   Steroid and Other Receptors:
                   Modulation of Gene Expression
                   and Other Cellular Responses

 1996 AM           4 Epidemiology for Toxicologists B                                                                             268 Epidemiology                         51



       9
                                                                                    Course Matrix Thru 2004



Year Time     #      Title                            B/A   Endorsed by   Endorsed by           Endorsed by   REG Topic                         Topic#        Chair   Co-Chair
 1996 AM           5 The Cell Cycle: Influence on     A                                                         219 Cell Biology                         33
                     Toxic Responses
 1996 AM           6 New Approaches for Studying      A                                                         139 Metabolism                           17
                     Cytochrome P450-Dependent
                     Toxicant Metabolism
 1996 AM           7 Aquatic Toxicology and Human     A                                                           94 Environmental Tox                   52
                     Health Risk Assessments:
                     Shared Metabolic Pathways,
                     Shared Mechanisms of Action,
                     Plus Data at the Bottom of the
                     Dose Response Curve

 1996 PM          10 Mitochondrial Injury in          B                                                         149 Mitochondrial                        44
                     Toxicology
 1996 PM          11 The Female Reproductive          B                                                         227 Reproductive                         9
                     System – How to Assess
                     Potential Toxicity
 1996 PM          12 Quantitative Uncertainty         B                                                         219 Risk Assessment                      55
                     Analysis in Risk Assessment:
                     Monte Carlo Techniques

 1996 PM        13 De-Regulation of ras Signaling     A                                                          57 Cell Proliferation/Signal            35
                   by Toxic Injury                                                                                  Transduction
 1996 PM        14 Applications of PCR                A                                                         129 Molecular Biology                    43
                   Technologies to Molecular                                                                        (techniques)
                   Toxicology
 2002              TOTAL                                                                                       1968
 1995 AM/PM   1,7 Basic Molecular Methods for         B                                                               Gene Expression                    38
                   the Analysis of Gene
                   Regulation and Expression
 1995 AM         2 New Endpoints in                   B                                                               Developmental Toxicity             15
                   Developmental and
                   Reproductive Regulatory
                   Studies: Methods for Success

 1995 AM           3 Cytokines and Growth Factors     B                                                               Cytokines                          37
                     in Toxicity
 1995 AM           4 In Vitro Methods for Product     B                                                               In Vitro Methods                   42
                     Development and Safety
                     Assessment
 1995 AM           5 Cell Transformation and          B                                                               Carcinogenesis                     16
                     Chemical Carcinogenesis
 1995 AM           6 Basic Applications in Risk       A                                                               Risk Assessment                    55
                     Assessment
 1995 PM           8 Advanced Methods in              B                                                               Molecular Biology                  43
                     Molecular Biology for                                                                            (techniques)
                     Toxicologists
 1995 PM           9 Basic Concepts of Endocrine      B                                                               Endocrine System                   2
                     Disruption and Its Role in                                                                       (Disrupters)
                     Tumorigenesis
 1995 PM          10 Comparative and Cellular         B                                                               Liver                              7
                     Aspects of Liver Toxicity
 1995 PM          11 Ecotoxicology: Responses,        B                                                               Environmental Tox                  52
                     Biomarkers, and Risk
                     Assessment



       10
                                                                                    Course Matrix Thru 2004



Year Time     #    Title                              B/A   Endorsed by   Endorsed by           Endorsed by   REG   Topic                      Topic#        Chair   Co-Chair
 1995 PM        12 Advances in Risk                   A                                                             Risk Assessment                     55
                   Extrapolation: Dose-Response
                   Assessment
 1994 AM         1 Molecular Mechanisms                                                                             Gene Expression                     38
                   Controlling Gene Expression
 1994 AM/PM   2,7 Toxicokinetics: Study Design        B                                                             Pharmacokinetics-PBPK               18
                   and Data Analysis
 1994 AM         3 Molecular Biomarkers in            A                                                             Molecular Biomarkers                45
                   Toxicology
 1994 AM         4 International Harmonization:       B                                                             Regulatory/Harmonization            54
                   Update on Scientific and
                   Regulatory Issues
 1994 AM         5 In Vitro Neurotoxicology:                                                                        In Vitro Methods                    42
                   Principles, Practice and
                   Paradigms
 1994 AM         6 Target Organ Toxicology:                                                                         Respiratory                         10
                   Respiratory Tract Dosimetry
                   and Response to Inhaled
                   Toxicants
 1994 PM         8 Strategies for Cloning Toxicant-   B                                                             Molecular Biology                   43
                   Inducible Genes                                                                                  (techniques)
 1994 PM         9 Sensory System Toxicology          B                                                             Nervous System                       8
 1994 PM        10 International Harmonization:                                                                     Regulatory/Harmonization            54
                   Update on Scientific and
                   Regulatory Issues
 1994 PM        11 Genetic Toxicology: Current                                                                      Genetic Toxicology                  39
                   Regulatory Guidelines and
                   New Technologies
 1994 PM        12 Pulmonary Immune Responses         B                                                             Immune System                       5

 1993 AM         1 Advanced Behavioral and            A                                                             Nervous System                      8
                   Neurophysiological Testing for
                   Neurotoxicity
 1993 AM         2 Molecular Biomarkers in            B                                                             Molecular Biomarkers                45
                   Toxicology
 1993 AM         3 Insecticides: Mechanisms of        B                                                             Pesticides                          28
                   Action, Metabolism and
                   Toxicology in Vertebrates
 1993 AM         4 Coping with Nongenotoxic           B                                                             Non-Genotoxic                       27
                   Carcinogens: Mode of Action                                                                      Carcinogens
                   Detection and Risk
                   Assessment
 1993 AM      5,7 Mechanisms of Cell Death            A                                                             Cell Death                          34
 1993 AM/PM   6,8 Basic Risk Assessment:              B                                                             Risk Assessment                     55
                   Current Developments
 1993 PM         9 Immunology of Chemical             B                                                             Immune System                       5
                   Hypersensitivity
 1993 PM        10 Advanced Topics in Risk            A                                                             Risk Assessment                     55
                   Assessment
 1993 PM        11 Experimental Approaches to         A                                                             Gene Expression                     38
                   Assess Chemically-Induced
                   Alterations in Gene Expression

 1993 PM          12 Application of Advanced          B                                                             Molecular Biology                   43
                     Technologies to Problems in                                                                    (techniques)
                     Toxicology


       11
                                                                                    Course Matrix Thru 2004



Year Time     #    Title                              B/A   Endorsed by   Endorsed by           Endorsed by   REG   Topic                       Topic#        Chair   Co-Chair
 1992 AM         1 Basic and Applied                  B                                                             Liver                                7
                   Hematotoxicity
 1992 AM/PM   2,7 Case Studies in Risk                B                                                             Risk Assessment                      55
                   Assessment: Emphasis on
                   Exposure
 1992 AM         3 Development and Safety             B                                                             Biotech Products                     21
                   Evaluation of Recombinant
                   Products for Pharmaceutical
                   and Agricultural Use
 1992 AM/PM   4,9 Implementing Physiologically-       B                                                             Modeling                             53
                   Based Pharmacokinetic
                   Models-Interactive Computer
                   Session
 1992 AM         5 Liver Toxicology                   B                                                             Liver                                 7
 1992 AM/PM   6,10 Molecular Control of Cell          B                                                             Cell Proliferation/Signal            35
                   Proliferation                                                                                    Transduction
 1992 PM         8 Developmental Toxicity:            B                                                             Developmental Toxicity               15
                   Cellular and Molecular
                   Approaches
 1992 PM        11 Renal Toxicology                   B                                                             Kidney                                6
 1992 PM        12 Toxicity of Halogenated            B                                                             Halogenated Compounds                24
                   Hydrocarbons
 1991              Introduction to Physiologically-                                                                 Modeling                             53
                   Based Pharmacokinetic
                   Modeling
 1991              Environmental Toxicology                                                                         Environmental Tox                    52
 1991              Toxicity of Agents: Metals                                                                       Metals                               25
 1991              Female Reproductive                                                                              Reproductive                          9
                   Toxicology
 1991              Risk Communication:                                                                              Risk Communication                   56
                   Problems, Perceptions and
                   Practice
 1991              Advanced Molecular                                                                               Molecular Biology                    43
                   Toxicology Application of                                                                        (techniques)
                   Molecular Biology in Toxicology

 1991              Implementing Physiologically-                                                                    Modeling                             53
                   Based Pharmacokinetic
                   Models
 1991              Advanced Neurotoxicology                                                                         Nervous System                        8
 1991              Advanced Immunotoxicology                                                                        Immune System                         5
 1991              Naturally Occurring Toxins                                                                       Naturally-Occurring                  26
 1991              Novel Techniques in Inhalation                                                                   Inhalation Methods                   41
                   Toxicology
 1991              Risk Communication:                                                                              Risk Communication                   56
                   Problems, Perceptions and
                   Practice
 1991              Advanced Molecular              A                                                                Molecular Biology                    43
                   Toxicology: Application of                                                                       (techniques)
                   Molecular Biology In Toxicology

 1990              Target Organ Toxicity:        B                                                                  Cardiovascular                       1
                   Cardiovascular Toxicity
 1990              Developmental Toxicity:       B                                                                  Developmental Toxicity               15
                   Changing Factors In Embryonic
                   Susceptibility
 1990              Advanced Metabolism           A                                                                  Metabolism                           17
        12
                                                                                Course Matrix Thru 2004



Year Time    #   Title                            B/A   Endorsed by   Endorsed by           Endorsed by   REG   Topic                  Topic#        Chair   Co-Chair
 1990            Advanced Hepatotoxicity          A                                                             Liver                            7
 1990            Concepts in Cell Biology                                                                       Cell Biology                    33
 1990            Carcinogen Risk Assessment                                                                     Risk Assessment                 55

 1990            Advanced Hepatotoxicity          B                                                             Liver                            7
 1990            Free Radical Toxicology                                                                                          46             4
 1990            Target Organ Toxicity:           B                                                             Respiratory                     10
                 Respiratory Tract Toxicology
 1990            Toxicity of Agents: Pesticides                                                                 Pesticides                      28

 1990            Concepts In Cell Biology                                                                       Cell Biology                    33
 1990            Carcinogen Risk Assessment                                                                     Risk Assessment                 55




        13
Topic# Topic                                     Class
    1   Cardiovascular                           Target Organs
    2   Endocrine System (Disrupters)            Target Organs
    3   Gastrointestinal                         Target Organs
    4   Hematology                               Target Organs
    5   Immune System                            Target Organs
    6   Kidney                                   Target Organs
    7   Liver                                    Target Organs
    8   Nervous System                           Target Organs
    9   Reproductive                             Target Organs
   10   Respiratory                              Target Organs
   11   Skin                                     Target Organs
   12   Musculoskeletar                          Target Organs
   13   Eye                                      Target Organs
   14   Blank                                    Target Organs
   15   Developmental Toxicity                   Developmental Toxicity
   16   Carcinogenesis                           Carcinogenesis
   17   Metabolism                               Metabolism
   18   Pharmacokinetics-PBPK                    Pharmacokinetics-PBPK
   19   Blank                                    System
   20   Blank                                    System
   21   Biotech Products                         Agents
   22   Foods                                    Agents
   23   Free-Radicals                            Agents
   24   Halogenated Compounds                    Agents
   25   Metals                                   Agents
   26   Naturally-Occurring                      Agents
   27   Non-Genotoxic Carcinogens                Agents
   28   Pesticides                               Agents
   29   Hydrocarbons, polycyclic                 Agents
   30   Blank                                    Agents
   31   Blank                                    Agents
   32   Phototocity                              Methods/Mechanisms
   33   Cell Biology                             Methods/Mechanisms
   34   Cell Death                               Methods/Mechanisms
   35   Cell Proliferation/Signal Transduction   Methods/Mechanisms
   36   Toxicant Interactions                    Methods/Mechanisms
   37   Cytokines                                Methods/Mechanisms
   38   Gene Expression                          Methods/Mechanisms
   39   Genetic Toxicology                       Methods/Mechanisms
   40   Genomics/Proteiomics                     Methods/Mechanisms
   41   Inhalation Methods                       Methods/Mechanisms
   42   In Vitro Methods                         Methods/Mechanisms
   43   Molecular Biology (techniques)           Methods/Mechanisms
   44   Mitochondrial                            Methods/Mechanisms
   45   Molecular Biomarkers                     Methods/Mechanisms
   46   Oxidative Stress                         Methods/Mechanisms
   47   Receptors, Steroid                       Methods/Mechanisms
   48   Clinical Pathology                       Methods/Mechanisms
   49   Blank                                    Methods/Mechanisms
   50   Saftey Pharmacology                      Applied/Other
   51   Epidemiology                             Applied/Other
Topic# Topic                           Class
   52   Environmental Tox              Applied/Other
   53   Modeling                       Applied/Other
   54   Regulatory/Harmonization       Applied/Other
   55   Risk Assessment                Applied/Other
   56   Risk Communication             Applied/Other
   57   Drug Development               Applied/Other
   58   Occupational Toxicology        Applied/Other
   59   Clinical Toxicology            Applied/Other
   60   Comparative & Veterinary Tox   Applied/Other
   61   Nanotechnology                 Applied/Other
Topic# Topic                                     Class                    New
    1   Cardiovascular                           Target Organs                   1
    2                                            Developmental Toxicity         15
    3   Endocrine System (Disrupters)            Target Organs                   2
    4   Gastrointestinal                         Target Organs                   3
    5   Hematology                               Target Organs                   4
    6   Immune System                            Target Organs                   5
    7   Kidney                                   Target Organs                   6
    8   Liver                                    Target Organs                   7
    9   Nervous System                           Target Organs                   8
   10   Reproductive                             Target Organs                   9
   11   Respiratory                              Target Organs                  10
   12   Skin                                     Target Organs                  11
   13                                            Carcinogenesis                 16
   14   Biotech Products                         Agents                         21
   15   Foods                                    Agents                         22
   16   Free-Radicals                            Agents                         23
   17   Halogenated Compounds                    Agents                         24
   18   Metals                                   Agents                         25
   19   Naturally-Occurring                      Agents                         26
   20   Non-Genotoxic Carcinogens                Agents                         27
   21   Pesticides                               Agents                         28
   22   Phototocity                              Agents                         29
   23   Cell Biology                             Methods/Mechanisms             33
   24   Cell Death                               Methods/Mechanisms             34
   25   Cell Proliferation/Signal Transduction   Methods/Mechanisms             35
   26   Toxicant Interactions                    Methods/Mechanisms             36
   27   Cytokines                                Methods/Mechanisms             37
   28   Gene Expression                          Methods/Mechanisms             38
   29   Genetic Toxicology                       Methods/Mechanisms             39
   30   Genomics/Proteiomics                     Methods/Mechanisms             40
   31   Inhalation Methods                       Methods/Mechanisms             41
   32   In Vitro Methods                         Methods/Mechanisms             42
   33                                            Metabolism                     17
   34   Molecular Biology (techniques)           Methods/Mechanisms             43
   35   Mitochondrial                            Methods/Mechanisms             44
   36   Molecular Biomarkers                     Methods/Mechanisms             45
   37                                            Pharmacokinetics-PBPK          18
   38   Receptors, Steroid                       Methods/Mechanisms             47
   39   Saftey Pharmacology                      Applied/Other                  50
   40   Epidemiology                             Applied/Other                  51
   41   Environmental Tox                        Applied/Other                  52
   42   Modeling                                 Applied/Other                  53
   43   Regulatory/Harmonization                 Applied/Other                  54
   44   Risk Assessment                          Applied/Other                  55
   45   Risk Communication                       Applied/Other                  56
   46   Drug Development                         Applied/Other                  57
   47   Musculoskeletar                          Target Organs                  12
   48   Clinical Toxicology                      Applied/Other                  59
   49   Comparative & Veterinary Tox             Applied/Other                  60
   50   Oxidative Stress                         Methods/Mechanisms             46
   51   Hydrocarbons, polycyclic                 Agents                         30
52 Occupational Toxicology   Applied/Other   58
   Eye                       Target Organs   13
                                             14
                                             19
                                             20
                                             31
                                             32
                                             48
                                             49

								
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