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An IACUC and ARF Newsletter
Animal Care Matters
New Per Diem Rates Protocol Review
The University’s Institutional Change in Investigator
Animal Care and Use Committee
All requests for change in the SPRING 2002
(IACUC) has approved the ani-
Principal Investigator (PI) of an
mal per diem rates for FY 2002-
I A C U C -a p p r o v e d p r o t o c o l I N S I D E TH I S I S SU E:
2003. These rates will become
should include an original signed From the IACUC Chair 2
effective July 1, 2002.
Assurance Statement from the
The IACUC has also directed The Lab Mouse 2
new PI. By doing so, the new PI
that Animal Resource Facilities assures the IACUC that all work New Per Diem Rates Insert
(ARF) adjust per diem and other in the protocol involving labora- Rodent Surgery 3
reimbursable rates annually to tory animals will be conducted in Quarantine & Stabilization 3
reflect changes in the costs for accordance with the Guide for the
IACUC Members 4
procuring and maintaining ani- Care and Use of Laboratory Ani-
mals for teaching and research. mals (the Guide), the Animal
Annual adjustments will allow Welfare Act (PL 89-544 and
animal investigators to plan their amendments), and the University
animal use over the life of a pro- Policies.
ject. Currently, costs for animal
care such as feed, bedding, and
NIH/AUP Review
caging have been increasing at an
annual rate of 3 to 5%. Investi- For new Animal Use Proposal
gators submitting grant applica- (AUP) submissions where NIH is 2002 IACUC Meetings
tions should consider providing the project’s funding source, the AUP
Date Deadline
for increases in animal costs when PI is required to submit one copy
Apr 4 Mar 25
considering multiyear budgets. A of the entire grant, including the May 2 Apr 22
table with the new rates can be SPAR Proposal/Award Processing Jun 6
found in this newsletter as an in- Form Page and the NIH Face May
27
sert and may also be viewed at the Page (Form Page 1). A signature Jul 11 Jun 24
ARF website (http:// on the second space in the Assur- Aug 1 Jul 22
uscm.med.sc.edu/ARF/ ance Statement is also needed as Sep 5 Aug 26
Oct 3 Sep 23
index.htm). a certification that all animal pro- Nov 7 Oct 28
For questions on these new cedures described in the grant ap-
rates, please contact Dr. Robert plication are included and accu-
Beattie at 777-8106 or rately described in the AUP.
PAGE 2 ANIMAL CARE MATTERS
From the IACUC Chair
If you still haven’t heard, or if you’ve There will be a couple of changes in the
heard it through other means, yes, it’s true, review of protocols. First, if a request for a
the costs of keeping laboratory animals at change in PI is to be made, an Assurance
USC will increase starting the first of July. Statement that is signed by the new PI should
The IACUC made this recommendation last be submitted to the IACUC. Second, if NIH
January after careful review of the costs of is the funding source for an animal proposal,
maintaining animals at ARF. Please bear a complete copy of the grant application
these new rates in mind when you figure the should be submitted with the AUP.
budget allocation in your next grant applica- These changes are necessary. These are
tion. measures we have to take to further ensure
The IACUC has also adopted guidelines that USC continues to achieve the highest
on the quarantine and stabilization of all standards for laboratory animal care and use.
laboratory animals received and maintained The IACUC expects everyone’s full coopera-
by ARF. We want to make sure that we use tion and support of these changes. Please call
healthy, stable animals that won’t compro- me for any question or concern that you
mise our research results. may have.
Dr. Donald O. Allen, Chair
The Common Laboratory Mouse
No other mammal has been used in such Daily water . . . . . . . . . . . . . . 6 mls
numbers or in so many biomedical experi- GI transit time . . . . . . . . . . . 8–14 hrs
ments as the common laboratory mouse. But Heart rate . . . . . . . . . . . . . . . 330–780/min
how much do we really know about these Respiratory rate . . . . . . . . . . . 84–230/min
“most favored” specimen? The following bio- Blood volume . . . . . . . . . . . . 76–80 ml/kg
logical and physiological data about the lab Blood pressure: male . . . . . . 113–147 mm Hg
mouse, Mus musculus, may prove helpful es- female . . . . 81-106 mm Hg
pecially to investigators and researchers when
Cycle length . . . . . . . . . . . . . 4–5 days*
designing their next experiments. Note that
Breeding life . . . . . . . . . . . . . 6–9 mos
the figures presented here are average.
Breeding age . . . . . . . . . . . . . 4–6 wks
Adult body weight . . . . . . . . 30 gms
Litter size . . . . . . . . . . . . . . . . 5–10 pups
Birth weight . . . . . . . . . . . . . 0.5–1.5 gms
Weaning age . . . . . . . . . . . . . 21 days
Rectal temperature . . . . . . . . 99.3ºF
Hematocrit . . . . . . . . . . . . . . 39-49 %
Diploid number . . . . . . . . . . 40
Hemoglobin . . . . . . . . . . . . . 10.2-16.6 mg/dl
Life span . . . . . . . . . . . . . . . . 1–2 years
Gestation period . . . . . . . . . 20 days
*postpartum estrus – receptive and fertile within hours
Daily Feed . . . . . . . . . . . . . . 4–6 gms after delivery
SPRING 2002 PAGE 3
Rodent Surgery
General requirements for rodent surgery undergo survival surgical procedures. Animal
are outlined in the Guide for Care and Use of users have the responsibility to provide ro-
Laboratory Animals (the Guide). The Asso- dents with adequate intra– and post-
ciation for Assessment and Accreditation of operative care.
Laboratory Animal Care International All surgical procedures should be de-
(AAALAC) endorses the Guide standards for scribed in the Annex C of the AUP and ap-
rodent surgery by requiring their accredited proved by the IACUC. The protocol should
institutions to have adequate procedures in also describe intra– and postoperative care,
place for conducting rodent surgery. Federal aseptic techniques, use of anesthetics, analge-
Regulations and Policies regarding care and sics, tranquilizers, and/or other treatments.
use of laboratory animals stress the impor- A list of all personnel who will perform the
tance of minimizing pain and distress in all surgical procedures, monitoring, and care
animal subjects, particularly those that will should also be included.
Quarantine and Stabilization of Animals
The IACUC has established the following fore their use. Such a period allows the ani-
guidelines for the quarantine and stabiliza- mal to recover from shipping stress, adapt to
tion of all animals received and maintained its new surroundings, and become physio-
by the Animal Resource Facilities (ARF). logically stable. Adequate acclimation times
may vary depending on the animal species,
An effective quarantine minimizes the
source, type and duration of transportation,
chance for introduction of pathogens into an
and the intended use for the animals.
established colony. Information from the
source on animal quality should be sufficient ⇒ For rodents, the recommended adapta-
to enable the Attending Veterinarian to de- tion is 72 hours (3 days), minimum, prior
termine the length of quarantine, to define to use in non-acute procedures.
the potential risks to personnel and animals ⇒ For all large animals (including rabbit)
within the colony, and, to determine whether undergoing non-acute procedures, the
therapy is required before animals are released recommended adaptation is 5 days,
from quarantine. Rodents might not require minimum.
quarantine if data from the source are suffi- All newly arrived animals that shall be
ciently current and complete, and if the po- used in teaching, research, or testing at USC
tential for exposure to pathogens during should be provided the minimum acclima-
transit is considered. tion periods described in these guidelines.
However, all newly received animals at Failure to allow animals to acclimatize could
USC should be given a period for physiologic, adversely affect animal health and research
psychologic, and nutritional stabilization be- data.
Campus Mail
ANIMAL CARE MATTERS
An IACUC and ARF Newsletter
Animal Resource Facilities
School of Medicine
Graduate Science Research Center
Columbia, South Carolina 29208
Phone: 803-777-8106
Fax: 803-777-2849
E-mail: pooser@gwm.sc.edu
We’re on the Web !!
http://uscm.med.sc.edu/
ARF/index.htm
A nimal Care Matters is pub-
lished four times a year by the
Institutional Animal Care and Use Com- IACUC MEMBERSHIP
mittee (IACUC) and Animal Resource
Facilities (ARF) of the University of CHAIRMAN
South Carolina (USC). Donald Allen, Ph.D.
The IACUC is an institutional body MEMBERS
appointed by the USC President to over- Nathan Alderson
see the program for the humane care and Robert Beattie, D.V.M.
use of all vertebrate animals used for James Carson, Ph.D.
research, teaching, and training. Any Wayne Carver, Ph.D.
investigator who intends to use labora- Destiny Hollis, Ph.D.
tory animals must submit an Animal Use Alexander McDonald, Ph.D.
Proposal (AUP) to the IACUC for its Marjorie Peña, Ph.D.
review and approval. Margaret Rentz
The ARF provides care and mainte- Kenneth Walsh, Ph.D.
nance of all animals used by investiga- Marlene Wilson, Ph.D.
tors. Preventive care is provided through Bao Ting Zhu, Ph.D.
vendor animal health evaluations, quar-
antine programs, and sentinel animal COMMUNITY MEMBERS
diagnostics. Special care and services can Janice Ayers
be provided upon request. Joe Hick, M.D.
Comments and submissions for CONSULTANTS
Animal Care Matters are welcome and Tommy Coggins
should be directed to Benilda P. Pooser, Charles Jeffcoat
Ph.D., IACUC Administrator, at 777-
8106 or pooser@gwm.sc.edu.
Animal Per Diem Rates 2002-2003
Effective July 1, 2002
ANIMAL TYPE/
SPECIES PER DIEM DISPOSAL NOTES
Rodents
Mouse Per diem is per cage. Whenever possible, mice are housed as
compatible groups of up to 5 adult mice per standard cage.
Conventional .39 .05 Includes microisolator top
Special care 1.22 .05 Sterile cage, feed, water (SCID, Nude)
Peromyscus .35 .05 Per cage
Rat
Conventional .56 .26
Special care .84 .26 Sterile cage, feed, water, frequent change, etc.
Female & litter .56 .79
Gerbil .39 .05
Guinea pig .60 .45
Hamster .39 .05
Rabbit 1.46 2.43
Other Mammals
Pig 6.89 24.25
Sheep/Goat 6.07 24.25 Indoors housing
Cat 2.43 2.43
Dog 4.08 24.25
Non-mammals
Frog (Rana sp.) .56 .05
Turtle .56 1.22
Xenopus 7.88 .05 Room per diem
Miscellaneous
Pig transport 115.76 Transport from Clemson farm unit to ARF
Pig conditioning 42.50
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