AACR Journals: Manuscript Classification and Reviewer Expertise Terms ORG ORGAN SITES AND TUMOR TYPES ___AIDS-related malignancies ___Brain/central nervous system cancers ___Breast cancer ___Gastrointestinal cancers: colorectal ___Gastrointestinal cancers: liver ___Gastrointestinal cancers: stomach ___Gastrointestinal cancers: other ___Genitourinary cancers: bladder ___Genitourinary cancers: prostate ___Genitourinary cancers: other ___Gynecological cancers: cervical ___Gynecological cancers: endometrial hyperplasia ___Gynecological cancers: ovarian ___Gynecological cancers: vulvar IEN ___Gynecological cancers: other ___Head and neck/oral cancers ___Hematologic, other ___Intraepithelial neoplasia (IEN) ___Leukemias and lymphomas ___Lung cancer ___Melanoma/skin cancers ___Pancreatic cancer ___Pediatric cancers ___Sarcoma/soft-tissue malignancies ___Thyroid/endocrine-related cancers
CG CARCINOGENESIS ___Animal/in vitro models for carcinogenesis ___Carcinogen-activating enzymes ___Carcinogen-detoxifying enzymes ___Chemical carcinogenesis ___DNA adducts: identification and function/repair and sequence specificity ___DNA damage and repair mechanisms ___Environmental carcinogenesis/toxicology ___Mutagenesis ___Predictive assays for carcinogenicity ___Premalignant lesions ___Radiation carcinogenesis ___Reactive oxygen and carcinogenesis ___Risk assessment ___Signal transduction ___Tobacco ___Tumor promotion and progression
CB CELLULAR, MOLECULAR, AND TUMOR BIOLOGY CB01 CELL CYCLE ___CDKs and CDK inhibitors ___Cell cycle checkpoints ___Control of cell cycle progression ___Cyclins ___Phosphorylation and proteolysis in cell cycle control ___Signal transduction pathways CB02 CELL GROWTH/SIGNALING PATHWAYS ___Autocrine-paracrine signaling ___Cell adhesion ___Cell and tissue kinetics ___Cell signaling ___Cell-cell interactions ___Cell-matrix interactions ___Cytosolic adaptors and intermediate molecules ___Growth factors: structure and function ___Guanine nucleotide binding proteins and effectors ___Organogenesis ___Phosphatases ___Protein serine-threonine kinases ___Protein tyrosine kinases ___Receptors: structure and function ___Tumor-stromal cell interactions CB03 CELL DEATH AND SENESCENCE ___bcl-2 pathways: anti- and proapoptotic ___Caspases ___Cell adhesion/cell-cell interactions in apoptosis ___Cellular aging and senescence ___Effectors of apoptosis ___Fas/tumor necrosis factor receptor family ___Genes and development ___Receptor-coupled signaling to apoptosis ___Survival factors ___Telomeres and telomerase ___Transcriptional control of apoptosis CB04 TUMOR PROGRESSION, INVASION, AND METASTASIS ___Cell adhesion and extracellular matrix ___Cell motility and migration ___Detection of occult metastasis ___Imaging of tumor progression and metastasis ___Inflammation and tumor development ___Metastasis/metastasis genes/metastasis models ___Protease-inhibitor systems ___Tumor markers and detection of metastasis
CB05 ANGIOGENESIS AND MICROCIRCULATION ___Angiogenesis inhibitors: endogenous and synthetic ___Angiogenic factors and receptors ___Endothelial cell functions ___Endothelial cell heterogeneity ___Mechanisms and signaling events ___Models of host-tumor interactions ___Molecular mechanisms of angiogenesis ___Tumor microcirculation and microenvironment CB06 MODEL ORGANISMS ___Animal models of cancer ___Cancer susceptibility genes ___Chemical mutagenesis and the generation of mouse cancer models ___Developmental phenotypes of cancer genes ___Noninvasive imaging in animal models CB07 BIOINFORMATICS AND COMPUTATIONAL MOLECULAR BIOLOGY ___Gene expression profiling ___Molecular modeling ___New algorithims ___New software for data analysis ___Unique database resources CB08 STEM CELL BIOLOGY CB09 MAPPING AND CLONING OF CANCER GENES ___Cloning strategies ___Comparative genomics ___LOH and marker studies ___Molecular cytogenetics ___Mutation detection methods CB10 MECHANISMS OF GENOMIC ALTERATIONS ___Chromosomal translocations: genomic aspects ___Gene amplification ___Genetic instability: multistep progression CB11 TUMOR SUPPRESSOR GENES - STRUCTURE AND FUNCTION ___APC ___BRCA1, BRCA2 ___Genotype/phenotype correlations— functional pathways ___Other tumor suppressor genes ___p53 ___Rb and family ___Suppressors of metastasis CB12 GENE EXPRESSION, CHROMATIN REGULATION, AND ONCOGENOMICS
___Cancer genome anatomy: comparative expression patterns ___Chromatin structure/higher order regulation, acetylation ___DNA methylation/epigenetics ___Functional genomics ___Imprinting and allele-specific expression ___New methods in tumor microdissection/comparative expressions ___Gene Expression:__Proteomics ___Silencing and reactivation of gene expression CB13 GENE REGULATION AND TRANSCRIPTIONAL CONTROL ___Antisense control of gene expression ___Inducible gene expression ___Mechanisms of transcription ___Oncogenic transcription factors: leukemias/lymphomas/solid tumors ___Posttranscriptional and translational control ___Promoter/enhancer analysis ___Protein phosphorylation and control of gene expression ___Protein-protein interactions in transcription factor function ___Gene Regulation:__Proteomics ___Transcriptional control of cell differentiation
CH CHEMISTRY CH01 DRUG DESIGN AND OPTIMIZATION ___Computational methods (CAAD, CAMM) ___In silico evaluation of targets and design of libraries ___Natural products ___SAR studies ___Screening strategies (assays and chemical libraries) ___Structural studies ___Synthesis CH02 STRUCTURAL BIOLOGY AND MOLECULAR INTERACTIONS ___Nuclear magnetic resonance ___Other biophysical methods ___Protein/DNA interactions ___Protein/protein interactions ___Small molecule/DNA interactions ___X-ray crystallography CH03 PROTEOMICS, MASS SPECTROMETRY, AND CHEMICAL BIOLOGY ___Organization and analysis of physiochemical data CH04 CHEMICAL ASPECTS OF CARCINOGENESIS ___Carcinogen metabolism ___Chemical Carcinogenesis:__DNA adducts: Identification and function/repair and sequence specificity ___Quantification of DNA damage CH05 CHEMISTRY OF IMAGING AGENTS AND RADIOTHERAPEUTICS
CL CLINICAL RESEARCH CL01 PHASE I - III CLINICAL TRIALS ___Phase I-III Trials__AIDS-related malignancies ___Phase I-III Trials__Brain/central nervous system cancers ___Phase I-III Trials__Breast cancer ___Phase I-III Trials__Gastrointestinal cancers: colorectal ___Phase I-III Trials__Gastrointestinal cancers: liver ___Phase I-III Trials__Gastrointestinal cancers: stomach ___Phase I-III Trials__Gastrointestinal cancers: other ___Phase I-III Trials__Genitourinary cancers: bladder ___Phase I-III Trials__Genitourinary cancers: prostate ___Phase I-III Trials__Genitourinary cancers: other ___Phase I-III Trials__Gynecological cancers: cervical ___Phase I-III Trials__Gynecological cancers: endometrial hyperplasia ___Phase I-III Trials__Gynecological cancers: ovarian ___Phase I-III Trials__Gynecological cancers: vulvar IEN ___Phase I-III Trials__Gynecological cancers: other ___Phase I-III Trials__Head and neck/oral cancers ___Phase I-III Trials__Hematologic, other ___Phase I-III Trials__Intraepithelial neoplasia (IEN) ___Phase I-III Trials__Leukemias and lymphomas ___Phase I-III Trials__Lung cancer ___Phase I-III Trials__Melanoma/skin cancers ___Phase I-III Trials__Pancreatic cancer ___Phase I-III Trials__Pediatric cancers ___Phase I-III Trials__Sarcoma/soft-tissue malignancies ___Phase I-III Trials__Thyroid/endocrine-related tumors CL02 DIAGNOSTIC IMAGING ___CT scans ___Gamma camera scans ___Imaging of animals ___Magnetic resonance imaging (MRI) ___PET scans ___Standard roentgenographs CL03 CLINICAL PHARMACOLOGY ___Biodistribution/toxicology ___Clinical drug resistance CL04 MODALITY-BASED CLINICAL RESEARCH ___Adjuvant chemotherapy ___Alternative medicine research ___Cell-based therapeutics ___Clinical Research:__Differentiation therapy ___Gene therapy clinical trials ___Surgery: techniques and strategies
___Transplantation: bone marrow and stem cell CL05 PAIN AND PALLIATIVE CARE CL06 CLINICAL ENDOCRINOLOGY ___Hormone receptors and diagnosis/prognosis ___Hormone synthesis, metabolism, and inhibitors ___Neuroendocrine and other endocrine factors ___Retinoid-based cancer therapy CL07 CLINICAL IMMUNOLOGY: BIOLOGICAL THERAPY ___Clinical Immunology:__Allogeneic stem cell transplantation ___Antibody immunotherapy ___Clinical Immunology:__Autologous stem cell transplantation ___Clinical Immunology:__Cancer vaccines ___Clinical Immunology:__Cellular immunotherapy ___Clinical Immunology:__Graft versus host disease ___Clinical Immunology:__Hematopoietic stem cell transplantation ___Immunodiagnosis ___Minimal residual disease ___Preparative regimens for stem cell transplantation ___Clinical Immunology:__Reconstitution after stem cell transplantation ___Toxicities CL08 CLINICAL RESEARCH: MOLECULAR ONCOLOGY ___Cytogenetics and clinical molecular genetics ___Cytokines ___Laboratory correlates ___Molecular diagnosis and prognosis ___Molecular markers of metastasis and progression ___Oncogenes ___Suppressor genes ___Tumor staging: correlation of clinical and molecular markers
EN ENDOCRINOLOGY: MOLECULAR AND PRECLINICAL ___Growth factors and receptors ___Hormonal carcinogenesis ___Hormonal control ___Hormone signaling and inhibitors ___Nuclear receptors: structure and function ___Preclinical studies of endocrine-related cancers ___Receptors and signal transduction ___Retinoids and receptors ___Steroid hormones and receptors
EP EPIDEMIOLOGY EP01 DESCRIPTIVE, RISK FACTOR, AND METHODOLOGICAL STUDIES
___Behavioral epidemiology ___Cancer in minority and medically underserved populations ___Diet, alcohol, smoking, and other lifestyle risk factors ___Environmental and occupational epidemiology ___Infections and the etiology of cancer ___Methodology, modeling, and biostatistics ___Radiation exposure and cancer risk ___Reproductive, hormonal, and related risk factors EP02 BIOMARKERS OF DNA DAMAGE/REPAIR, EXPOSURE, AND PHENOTYPE ___Biomarkers of human exposure to carcinogens and DNA damaging agents ___DNA repair polymorphisms and risk ___Genotype-phenotype correlations ___Intermediate or pre-neoplastic markers and risk factors ___Serum biomarkers of endogenous exposures (hormones, growth factors, etc.) ___Somatic alterations and genetic and environmental risk factors EP03 GENETICS OF RISK, OUTCOME, AND PREVENTION ___Polymorphisms in carcinogen metabolism and cancer risk ___Polymorphisms in genes related to androgen and estrogen metabolism in cancer risk ___Polymorphisms in genes related to cell growth, differentiation, metastatic potential, and apoptosis in cancer risk ___Polymorphisms in genes that modify dietary exposures ___Polymorphisms related to inflammation, immune response, and oxidative damage in cancer risk EP04 METHODOLOGICAL STUDIES ___Familial and hereditary cancers ___Methodology for microarrays ___Methodology for proteomics ___Methodology for SNP data analysis ___Methodology for SNP detection ___Statistical methods in genetics
ET EXPERIMENTAL AND MOLECULAR THERAPEUTICS ET01 DRUG DISCOVERY TECHNOLOGIES ___Biochemical modulators of the therapeutic index ___Combination chemotherapy ___Differentiation therapy ___New targets ___Novel assay technology ___Novel drug delivery systems ___Screening strategies (assays) ___Xenograft models ET02 MECHANISMS OF DRUG ACTION/NEW MOLECULAR TARGETS/THERAPEUTICS ___Cell cycle mechanisms of anticancer drug action ___Cellular responses to anticancer drugs ___Drug-mediated stimulation of cell death pathways ___Modulation of DNA repair
___p53 and anticancer drug action ET03 DRUG RESISTANCE ___ATP-dependent transporters and drug resistance ___Biochemistry of membrane metabolism and transport ___Drug transport and metabolism ___Glutathione metabolism ___Non-transporter-related multidrug resistance ___Novel mechanisms ___Regulation of gene expression in drug resistance ___Reversal of drug resistance ___Structure and function of ABC transporters ET04 MOLECULAR AND CELLULAR PHARMACOLOGY/PHARMACOGENETICS/PHARMACOGENOMICS ___Cellular pharmacology ___Molecular pharmacology ___Pharmacogenetics/pharmacogenomics ___Pharmacokinetics and pharmacodynamics ___Preclinical toxicology ET05 SMALL MOLECULES AND OTHER THERAPEUTIC AGENTS ___Agents with other mechanisms of action ___Alkylating agents ___Antifolates ___DNA-reactive agents ___Farnesyltransferase inhibitors ___Kinase and phosphatase inhibitors ___Novel antitumor agents ___Platinum complexes ___Topoisomerases ___Tubulin-targeted agents ET06 BIOLOGICAL THERAPEUTIC AGENTS ___Antireceptors ___Antisense oligonucleotides ___Growth factor receptors and other surface molecules as targets for therapy ___Oncogenes, tumor suppressor genes, and gene products as targets for therapy ___Protein kinase and phosphatases as targets for therapy ET07 EXPERIMENTAL GENE THERAPY ___Antisense/ribozyme decoys ___Cell-type specific expression regulation of suicide genes ___Nonbiological delivery systems ___Progenitor cell targeting ___Vector systems and targeting strategies
IM IMMUNOLOGY IM01 Tumor Immunobiology
___Allogeneic stem cell transplantation ___Animal/transgenic models for tumor immunobiology ___Antibodies/immunoconjugates ___Autologous stem cell transplantation ___Cancer vaccines ___Cellular immunotherapy ___Graft versus host disease ___Graft versus tumor effect ___Hematopoietic stem cell transplantation ___Immune responses to cancer ___Immunomodulation ___Lymphokines, cytokines, chemokines, and growth factors ___Reconstitution after stem cell transplantation ___Tumor antigens ___Tumor resistance to immune response
PR PREVENTION PR01 PRECLINICAL STUDIES: BIOMARKERS AND PREVENTION ___Animal/transgenic models in promotion and prevention ___Biological and biochemical mechanisms in prevention ___Biomarkers and intervention studies ___Cellular models in prevention research ___Chemoprevention ___Diet and cancer ___Modulators of arachidonic acid metabolism ___Molecular markers in prevention research ___Treatment of intraepithelial neoplasia (IEN) PR02 CLINICAL PREVENTION STUDIES ___Biomarkers and intervention ___Cancer surveillance and screening ___Chemoprevention clinical trials ___Genetic markers as surrogate endpoints in prevention trials ___Genomics and proteomics in cancer risk and response assessment ___International clinical prevention studies ___Molecular pathology in clinical prevention ___Prevention and treatment of premalignant lesions (IENs) ___Prevention of second cancers ___Prophylactic surgery in prevention ___Recruitment of special populations in clinical prevention trials ___Translational models of chemoprevention PR03 BEHAVIORAL PREVENTION RESEARCH PR04 SURVIVORSHIP RESEARCH ___Addictive substances/nicotine ___Epidemiology of survivorship ___Long-term toxicities
___Psychosocial aspects ___Quality of life research ___Second cancers
RD RADIATION ONCOLOGY: PRECLINICAL AND CLINICAL ___Clinical radiotherapeutic studies ___Combined modality therapies ___Modification of radiation sensitivity ___Molecular targets of radiation response ___Normal tissue response to radiation ___Radiation resistance ___Radiation-induced late effects/second cancers ___Radioprotectors and radiosensitizers
RB RADIOBIOLOGY ___ATM ___Cell cycle and apoptosis in radiation responses ___Cytokines in radiation response ___DNA damage, DNA repair, and mutagenesis ___Experimental radiotherapeutics ___Molecular modulators of radiation response ___Oncogenes and tumor suppressor genes in radiation responses ___Photobiology/photodynamic therapy ___Radiobiology:__Radiation resistance ___Radiation-activated signaling pathways ___Radiation-induced biochemical alterations: conformation and function ___Radiation-induced gene expression ___Radiobiology:__Radioprotectors and radiosensitizers ___Tumor microenvironment and modification
VI VIRAL ONCOGENESIS AND MECHANISMS ___DNA tumor viruses ___Host-virus interactions ___Human tumor viruses ___Retroviruses ___Viral transformation and carcinogenesis
ORG ORGAN SITES AND TUMOR TYPES AIDS-related malignancies Brain/central nervous system cancers Breast cancer Gastrointestinal cancers: colorectal Gastrointestinal cancers: liver Gastrointestinal cancers: stomach Gastrointestinal cancers: other Genitourinary cancers: bladder Genitourinary cancers: prostate Genitourinary cancers: other Gynecological cancers: cervical Gynecological cancers: endometrial hyperplasia Gynecological cancers: ovarian Gynecological cancers: vulvar IEN Gynecological cancers: other Head and neck/oral cancers Hematologic, other Intraepithelial neoplasia (IEN) Leukemias and lymphomas Lung cancer Melanoma/skin cancers Pancreatic cancer Pediatric cancers Sarcoma/soft-tissue malignancies Thyroid/endocrine-related cancers
CG CARCINOGENESIS Animal/in vitro models for carcinogenesis Carcinogen-activating enzymes Carcinogen-detoxifying enzymes Chemical carcinogenesis DNA adducts: identification and function/repair and sequence specificity DNA damage and repair mechanisms Environmental carcinogenesis/toxicology Mutagenesis Predictive assays for carcinogenicity Premalignant lesions Radiation carcinogenesis Reactive oxygen and carcinogenesis Risk assessment Signal transduction Tobacco Tumor promotion and progression
CB CELLULAR, MOLECULAR, AND TUMOR BIOLOGY CB01 CELL CYCLE CDKs and CDK inhibitors Cell cycle checkpoints Control of cell cycle progression Cyclins Phosphorylation and proteolysis in cell cycle control Signal transduction pathways CB02 CELL GROWTH/SIGNALING PATHWAYS Autocrine-paracrine signaling Cell adhesion Cell and tissue kinetics Cell signaling Cell-cell interactions Cell-matrix interactions Cytosolic adaptors and intermediate molecules Growth factors: structure and function Guanine nucleotide binding proteins and effectors Organogenesis Phosphatases Protein serine-threonine kinases Protein tyrosine kinases Receptors: structure and function Tumor-stromal cell interactions CB03 CELL DEATH AND SENESCENCE bcl-2 pathways: anti- and proapoptotic Caspases Cell adhesion/cell-cell interactions in apoptosis Cellular aging and senescence Effectors of apoptosis Fas/tumor necrosis factor receptor family Genes and development Receptor-coupled signaling to apoptosis Survival factors Telomeres and telomerase Transcriptional control of apoptosis CB04 TUMOR PROGRESSION, INVASION, AND METASTASIS Cell adhesion and extracellular matrix Cell motility and migration Detection of occult metastasis Imaging of tumor progression and metastasis Inflammation and tumor development Metastasis/metastasis genes/metastasis models Protease-inhibitor systems Tumor markers and detection of metastasis
CB05 ANGIOGENESIS AND MICROCIRCULATION Angiogenesis inhibitors: endogenous and synthetic Angiogenic factors and receptors Endothelial cell functions Endothelial cell heterogeneity Mechanisms and signaling events Models of host-tumor interactions Molecular mechanisms of angiogenesis Tumor microcirculation and microenvironment CB06 MODEL ORGANISMS Animal models of cancer Cancer susceptibility genes Chemical mutagenesis and the generation of mouse cancer models Developmental phenotypes of cancer genes Noninvasive imaging in animal models CB07 BIOINFORMATICS AND COMPUTATIONAL MOLECULAR BIOLOGY Gene expression profiling Molecular modeling New algorithims New software for data analysis Unique database resources CB08 STEM CELL BIOLOGY CB09 MAPPING AND CLONING OF CANCER GENES Cloning strategies Comparative genomics LOH and marker studies Molecular cytogenetics Mutation detection methods CB10 MECHANISMS OF GENOMIC ALTERATIONS Chromosomal translocations: genomic aspects Gene amplification Genetic instability: multistep progression CB11 TUMOR SUPPRESSOR GENES - STRUCTURE AND FUNCTION APC BRCA1, BRCA2 Genotype/phenotype correlations— functional pathways Other tumor suppressor genes p53 Rb and family Suppressors of metastasis CB12 GENE EXPRESSION, CHROMATIN REGULATION, AND ONCOGENOMICS
Cancer genome anatomy: comparative expression patterns Chromatin structure/higher order regulation, acetylation DNA methylation/epigenetics Functional genomics Imprinting and allele-specific expression New methods in tumor microdissection/comparative expressions Gene Expression:__Proteomics Silencing and reactivation of gene expression CB13 GENE REGULATION AND TRANSCRIPTIONAL CONTROL Antisense control of gene expression Inducible gene expression Mechanisms of transcription Oncogenic transcription factors: leukemias/lymphomas/solid tumors Posttranscriptional and translational control Promoter/enhancer analysis Protein phosphorylation and control of gene expression Protein-protein interactions in transcription factor function Gene Regulation:__Proteomics Transcriptional control of cell differentiation
CH CHEMISTRY CH01 DRUG DESIGN AND OPTIMIZATION Computational methods (CAAD, CAMM) In silico evaluation of targets and design of libraries Natural products SAR studies Screening strategies (assays and chemical libraries) Structural studies Synthesis CH02 STRUCTURAL BIOLOGY AND MOLECULAR INTERACTIONS Nuclear magnetic resonance Other biophysical methods Protein/DNA interactions Protein/protein interactions Small molecule/DNA interactions X-ray crystallography CH03 PROTEOMICS, MASS SPECTROMETRY, AND CHEMICAL BIOLOGY Organization and analysis of physiochemical data CH04 CHEMICAL ASPECTS OF CARCINOGENESIS Carcinogen metabolism Chemical Carcinogenesis:__DNA adducts: Identification and function/repair and sequence specificity Quantification of DNA damage CH05 CHEMISTRY OF IMAGING AGENTS AND RADIOTHERAPEUTICS
CL CLINICAL RESEARCH CL01 PHASE I - III CLINICAL TRIALS Phase I-III Trials__AIDS-related malignancies Phase I-III Trials__Brain/central nervous system cancers Phase I-III Trials__Breast cancer Phase I-III Trials__Gastrointestinal cancers: colorectal Phase I-III Trials__Gastrointestinal cancers: liver Phase I-III Trials__Gastrointestinal cancers: stomach Phase I-III Trials__Gastrointestinal cancers: other Phase I-III Trials__Genitourinary cancers: bladder Phase I-III Trials__Genitourinary cancers: prostate Phase I-III Trials__Genitourinary cancers: other Phase I-III Trials__Gynecological cancers: cervical Phase I-III Trials__Gynecological cancers: endometrial hyperplasia Phase I-III Trials__Gynecological cancers: ovarian Phase I-III Trials__Gynecological cancers: vulvar IEN Phase I-III Trials__Gynecological cancers: other Phase I-III Trials__Head and neck/oral cancers Phase I-III Trials__Hematologic, other Phase I-III Trials__Intraepithelial neoplasia (IEN) Phase I-III Trials__Leukemias and lymphomas Phase I-III Trials__Lung cancer Phase I-III Trials__Melanoma/skin cancers Phase I-III Trials__Pancreatic cancer Phase I-III Trials__Pediatric cancers Phase I-III Trials__Sarcoma/soft-tissue malignancies Phase I-III Trials__Thyroid/endocrine-related tumors CL02 DIAGNOSTIC IMAGING CT scans Gamma camera scans Imaging of animals Magnetic resonance imaging (MRI) PET scans Standard roentgenographs CL03 CLINICAL PHARMACOLOGY Biodistribution/toxicology Clinical drug resistance CL04 MODALITY-BASED CLINICAL RESEARCH Adjuvant chemotherapy Alternative medicine research Cell-based therapeutics Clinical Research:__Differentiation therapy Gene therapy clinical trials Surgery: techniques and strategies
Transplantation: bone marrow and stem cell CL05 PAIN AND PALLIATIVE CARE CL06 CLINICAL ENDOCRINOLOGY Hormone receptors and diagnosis/prognosis Hormone synthesis, metabolism, and inhibitors Neuroendocrine and other endocrine factors Retinoid-based cancer therapy CL07 CLINICAL IMMUNOLOGY: BIOLOGICAL THERAPY Clinical Immunology:__Allogeneic stem cell transplantation Antibody immunotherapy Clinical Immunology:__Autologous stem cell transplantation Clinical Immunology:__Cancer vaccines Clinical Immunology:__Cellular immunotherapy Clinical Immunology:__Graft versus host disease Clinical Immunology:__Hematopoietic stem cell transplantation Immunodiagnosis Minimal residual disease Preparative regimens for stem cell transplantation Clinical Immunology:__Reconstitution after stem cell transplantation Toxicities CL08 CLINICAL RESEARCH: MOLECULAR ONCOLOGY Cytogenetics and clinical molecular genetics Cytokines Laboratory correlates Molecular diagnosis and prognosis Molecular markers of metastasis and progression Oncogenes Suppressor genes Tumor staging: correlation of clinical and molecular markers
EN ENDOCRINOLOGY: MOLECULAR AND PRECLINICAL Growth factors and receptors Hormonal carcinogenesis Hormonal control Hormone signaling and inhibitors Nuclear receptors: structure and function Preclinical studies of endocrine-related cancers Receptors and signal transduction Retinoids and receptors Steroid hormones and receptors
EP EPIDEMIOLOGY EP01 DESCRIPTIVE, RISK FACTOR, AND METHODOLOGICAL STUDIES
Behavioral epidemiology Cancer in minority and medically underserved populations Diet, alcohol, smoking, and other lifestyle risk factors Environmental and occupational epidemiology Infections and the etiology of cancer Methodology, modeling, and biostatistics Radiation exposure and cancer risk Reproductive, hormonal, and related risk factors EP02 BIOMARKERS OF DNA DAMAGE/REPAIR, EXPOSURE, AND PHENOTYPE Biomarkers of human exposure to carcinogens and DNA damaging agents DNA repair polymorphisms and risk Genotype-phenotype correlations Intermediate or pre-neoplastic markers and risk factors Serum biomarkers of endogenous exposures (hormones, growth factors, etc.) Somatic alterations and genetic and environmental risk factors EP03 GENETICS OF RISK, OUTCOME, AND PREVENTION Polymorphisms in carcinogen metabolism and cancer risk Polymorphisms in genes related to androgen and estrogen metabolism in cancer risk Polymorphisms in genes related to cell growth, differentiation, metastatic potential, and apoptosis in cancer risk in genes that modify dietary exposures Polymorphisms Polymorphisms related to inflammation, immune response, and oxidative damage in cancer risk EP04 METHODOLOGICAL STUDIES Familial and hereditary cancers Methodology for microarrays Methodology for proteomics Methodology for SNP data analysis Methodology for SNP detection Statistical methods in genetics
ET EXPERIMENTAL AND MOLECULAR THERAPEUTICS ET01 DRUG DISCOVERY TECHNOLOGIES Biochemical modulators of the therapeutic index Combination chemotherapy Differentiation therapy New targets Novel assay technology Novel drug delivery systems Screening strategies (assays) Xenograft models ET02 MECHANISMS OF DRUG ACTION/NEW MOLECULAR TARGETS/THERAPEUTICS Cell cycle mechanisms of anticancer drug action Cellular responses to anticancer drugs Drug-mediated stimulation of cell death pathways Modulation of DNA repair
p53 and anticancer drug action ET03 DRUG RESISTANCE ATP-dependent transporters and drug resistance Biochemistry of membrane metabolism and transport Drug transport and metabolism Glutathione metabolism Non-transporter-related multidrug resistance Novel mechanisms Regulation of gene expression in drug resistance Reversal of drug resistance Structure and function of ABC transporters ET04 MOLECULAR AND CELLULAR PHARMACOLOGY/PHARMACOGENETICS/PHARMACOGENOMICS Cellular pharmacology Molecular pharmacology Pharmacogenetics/pharmacogenomics Pharmacokinetics and pharmacodynamics Preclinical toxicology ET05 SMALL MOLECULES AND OTHER THERAPEUTIC AGENTS Agents with other mechanisms of action Alkylating agents Antifolates DNA-reactive agents Farnesyltransferase inhibitors Kinase and phosphatase inhibitors Novel antitumor agents Platinum complexes Topoisomerases Tubulin-targeted agents ET06 BIOLOGICAL THERAPEUTIC AGENTS Antireceptors Antisense oligonucleotides Growth factor receptors and other surface molecules as targets for therapy Oncogenes, tumor suppressor genes, and gene products as targets for therapy Protein kinase and phosphatases as targets for therapy ET07 EXPERIMENTAL GENE THERAPY Antisense/ribozyme decoys Cell-type specific expression regulation of suicide genes Nonbiological delivery systems Progenitor cell targeting Vector systems and targeting strategies
IM IMMUNOLOGY IM01 Tumor Immunobiology
Allogeneic stem cell transplantation Animal/transgenic models for tumor immunobiology Antibodies/immunoconjugates Autologous stem cell transplantation Cancer vaccines Cellular immunotherapy Graft versus host disease Graft versus tumor effect Hematopoietic stem cell transplantation Immune responses to cancer Immunomodulation Lymphokines, cytokines, chemokines, and growth factors Reconstitution after stem cell transplantation Tumor antigens Tumor resistance to immune response
PR PREVENTION PR01 PRECLINICAL STUDIES: BIOMARKERS AND PREVENTION Animal/transgenic models in promotion and prevention Biological and biochemical mechanisms in prevention Biomarkers and intervention studies Cellular models in prevention research Chemoprevention Diet and cancer Modulators of arachidonic acid metabolism Molecular markers in prevention research Treatment of intraepithelial neoplasia (IEN) PR02 CLINICAL PREVENTION STUDIES Biomarkers and intervention Cancer surveillance and screening Chemoprevention clinical trials Genetic markers as surrogate endpoints in prevention trials Genomics and proteomics in cancer risk and response assessment International clinical prevention studies Molecular pathology in clinical prevention Prevention and treatment of premalignant lesions (IENs) Prevention of second cancers Prophylactic surgery in prevention Recruitment of special populations in clinical prevention trials Translational models of chemoprevention PR03 BEHAVIORAL PREVENTION RESEARCH PR04 SURVIVORSHIP RESEARCH Addictive substances/nicotine Epidemiology of survivorship Long-term toxicities
Psychosocial aspects Quality of life research Second cancers
RD RADIATION ONCOLOGY: PRECLINICAL AND CLINICAL Clinical radiotherapeutic studies Combined modality therapies Modification of radiation sensitivity Molecular targets of radiation response Normal tissue response to radiation Radiation resistance Radiation-induced late effects/second cancers Radioprotectors and radiosensitizers
RB RADIOBIOLOGY ATM Cell cycle and apoptosis in radiation responses Cytokines in radiation response DNA damage, DNA repair, and mutagenesis Experimental radiotherapeutics Molecular modulators of radiation response Oncogenes and tumor suppressor genes in radiation responses Photobiology/photodynamic therapy Radiobiology:__Radiation resistance Radiation-activated signaling pathways Radiation-induced biochemical alterations: conformation and function Radiation-induced gene expression Radiobiology:__Radioprotectors and radiosensitizers Tumor microenvironment and modification
VI VIRAL ONCOGENESIS AND MECHANISMS DNA tumor viruses Host-virus interactions Human tumor viruses Retroviruses Viral transformation and carcinogenesis