Certificate of Experience Clinical Research Employee by fmz12746

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									                         ST GEORGE’S, UNIVERSITY OF LONDON

                  DIVISION OF CARDIAC AND VASCULAR SCIENCES
                      (CENTRE FOR CLINICAL NEUROSCIENCE)

                                       JOB DESCRIPTION

       CLINICAL TRIAL/STUDY CO-ORDINATOR (RESEARCH ASSOCIATE)
                     STROKE CLINICAL TRIALS GROUP

                                           Ref: 400-10

INTRODUCTION

This is an exciting opportunity for a research associate to join one of the leading
stroke research groups in the UK.


The post holder will play an important role in co-ordination of trials within the stroke
group. Their primary role will be to co-ordinate a trial called CADISS which is looking
at whether treatment with antiplatelet agents (such as Aspirin) or anticoagulation
(such as Warfarin) is better at preventing recurrent stroke in patients who have had
carotid or vertebral dissection. Dissection is a rare cause of stroke but is particularly
common in younger individuals. This is a feasibility phase study before a possible
much larger trial. In this feasibility study we are recruit 250 individuals. The study is
already up and running and has recruited over 50 patients and we now have about
20 centres active within the UK.

The post holder will also help with co-ordination of other trials. They will provide
cover for the Vertebral Ischaemia Stenting Trial (VIST), which is looking at whether
stenting vertebral stenosis (narrowing of the vertebral artery supplying the brain) can
prevent stroke in patients who have already had stroke. This is being run by a
separate study co-ordinator but the two posts will cross-cover. In addition, they will
help with other ongoing studies, and new studies being set up, within the stroke
research group.

This post would be ideal for somebody with experience in clinical research who has
experience of managing clinical trials or other clinical studies. Previous experience in
stroke research is not essential.

The department has an active programme of stroke research both in clinical studies
and basic science studies. It leads a number of international trials and studies as
well as the above two trials. The department has an excellent record in training
young researchers in stroke and has an active post graduate research programme.


STROKE RESEARCH AT ST GEORGE’S

St George’s is one of the leading centres for stroke research in the United Kingdom
with internationally competitive teams in stroke imaging and stroke genetics within
Clinical Neuroscience, and carotid artery disease (Vascular Surgery, Professor Matt
Thompson, Dr Gill Cockerill, Miss Alison Halliday).

Our current stroke research programme is a combination of translational work and
clinical studies. Current work is funded from a variety of organisations including
programme grant support from the Stroke Association, British Heart Foundation,



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Wellcome Trust, and Research into Ageing, and project grant and studentship
support from the Stroke Association, MRC, PPP Healthcare, British Heart
Foundation, Neuroscience Research Foundation, St George’s Trustees.

Specific research areas within stroke include the following;

Clinical Trials in Stroke
The department leads a number of large scale studies looking at different aspects of
stroke prevention and treatment. These include CADISS trial looking at treatment of
cervical dissection (Professor John Norris, Professor Hugh Markus) and we have
recently been awarded funding to evaluate the use of vertebral stenting to prevent
recurrent stroke in patients with posterior circulation stroke and TIA (VIST trial).
Hugh Markus is principal investigator for this trial in collaboration with Professor
Peter Rothwell at Oxford. We are also co-ordinating the world’s largest study in
Doppler embolic signal detection – ACES (see below).

St George’s is an active recruiter to many trials in stroke run from outside St
George’s. In a recent evaluation we were the highest recruiting centre to Stroke
Research Network adopted trials in England.

The South East England Stroke Research Network is run from St George’s as part of
the UK clinical Stroke Research Network (clinical lead Hugh Markus). This provides
support for stroke research to South London, Kent, Surrey, Sussex, Hampshire and
the Isle of Wight.

Genetics of Ischaemic Stroke
Genetic studies are looking primarily at genetic risk factors for sporadic ischaemic
stroke. We have an active programme looking at the genetics of an intermediate
phenotype for stroke, carotid artery intima-media thickness We have recently been
awarded a functional genomics grant from the Wellcome Trust to establish a UK wide
DNA resource of young lacunar stroke. We are also investigating the genetics of
stroke in UK African Caribbeans as part of the South London Ethnicity and Stroke
project. We are also a national referral centre for single gene disorders causing
stroke, particularly CADASIL. We have just been awarded a Wellcome Trust grant to
lead an international collaboration performing a genome-wide screen in ischaemic
stroke.

Ultrasonic Imaging in Stroke
There is a well-established programme looking at both technical developments and
the clinical application of the use of Doppler ultrasound to detect asymptomatic
circulating emboli. This work ranges from signal processing to improve the detection
of emboli, to a large international multi-centre study to look at their predictive value.
We are co-ordinating the world’s largest study in Doppler embolic signal detection –
ACES.

Magnetic Resonance Imaging in Stroke
We have a long standing programme applying novel magnetic resonance imaging
techniques to investigate the pathogenesis of cerebrovascular disease, and
particularly sub cortical vascular disease. These studies apply a combination of
conventional MRI with diffusion tensor imaging, magnetic resonance spectroscopy,
and perfusion imaging. We work closely with the magnetic resonance spectroscopy
group within Basic Medical Science (Dr Franklyn Howe). We have particular
expertise in tractography applied to diffusion tensor imaging led by Dr Tom Barrick
(Lecturer in MR Image Analysis).

Other Research within Clinical Neuroscience



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Within Clinical Neuroscience there are also research groups in neurosurgery and
epilepsy.

Within Neurosurgery Professor Bell is involved in a programme applying magnetic
resonance spectroscopy, and more recently diffusion tensor imaging, to characterise
and plan neurosurgical interventions for intra-cerebral tumours. He also has a long-
standing interest in subarachnoid haemorrhage and the application of Xenon CT and
more recently perfusion CT to non-invasively assess cerebral haemodynamics in this
condition.

Dr Marios Papadopoulous has recently been appointed as Senior Lecturer in
Neurosurgery and leads a programme investigating the role of aquaporin channels in
neurological diseases particularly brain tumours.

Dr Hannah Cock, Senior Lecturer in Neurology, leads a group looking at epilepsy.


ACADEMIC AND RESEARCH STAFF IN THE CENTRE FOR CLINICAL
NEUROSCIENCES – AND THEIR INTERESTS

ACADEMIC AND RESEARCH STAFF IN THE CENTRE FOR CLINICAL
NEUROSCIENCES – AND THEIR INTERESTS

 Stroke Research Group
 Prof. Hugh Markus            Professor of Neurology                    Stroke
 Prof. John Norris            Honorary Professor in Neurology           Stroke
 Dr Steve Bevan               Non-clinical Senior Lecturer in Stroke    Stroke Genetics
                              Genetics
 Dr Atticus Hainsworth        Non-clinical Senior Lecturer              Stroke Basic science
 Dr Caroline Lovelock         Clinical Lecturer                         Stroke
 Dr Poneh Adib-Samii          Specialist Registrar                      Stroke Genetics
 Rebecca Brookes              Research Psychologist                     Neuropsychology
 Dr Rebecca Charlton          Research Psychologist                     Neuropsychology
 Jacqueline Coleman           Clinical Trials Co-ordinator              Stroke Trials
 Orlagh Flynn                 SELRN Co-ordinator                        Stroke Trials
 Tom James                    Stroke Database Administrator             Stroke databases
 Ifan Jones                   Assistant Clinical Studies Co-ordinator   Stroke Trials
 Alice King                   PhD Student                               Stroke Imaging
 Silvia Lanfranconi           Honorary Research Assistant               Stroke Genetics
 Andrew Lawrence              Research Psychologist                     Neuropsychology
 Ruben Lewis                  Clinical Trials Co-ordinator              Stroke Trials
 Dr Catherine McCaig          Postdoctoral Research Fellow              Stroke Models
 Rachel McMahon               Assistant Study Co-ordinator              Stroke Imaging
 Ann Marie Murtagh            SELRN Network Co-ordinator                Stroke Trials
 Lee Nathaniel-Wurie          Assistant Clinical Studies Co-ordinator   Stroke Trials
 Emma O’Connor                SRN Lead Nurse                            Stroke Trials
 Joanna O’Reilly              SELRN Clinical Studies Co-ordinator       Stroke Trials
 Adam Osman                   Research Technician                       Stroke Imaging




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 Dr Bhavini Patel             Clinical Research Fellow                     Stroke imaging
 Dr Dominic Paviour           Academic Clinical Lecturer                   Dementia
 Sophie Payne                 Assistant Clinical Studies Co-ordinator      Stroke Trials
 Barbara Sawyer               NC3R Research Technician                     Stroke Models
 Francesca Schiavone          Research Governance Facilitator              Stroke Trials
 Eithne Smith                 Study Co-ordinator                           Stroke Genetics
 Melina Wilson                Study Co-ordinator                           Stroke Trials


 Epilepsy Research Group
 Dr Hannah Cock               Clinical Senior Lecturer in Neurology        Epilepsy


 MR research group
 Dr Franklyn Howe             Reader in Magnetic Resonance Imaging         MR physics
 Dr Tom Barrick               Senior Lecturer in MR image analysis         MR image analysis
 Kirstie Opstad               Research Fellow                              MRI
 Ai Wern Chung                Research Fellow                              MR Image Analysis


 Other Neurology Research
 Dr Fred Schon                Honorary Reader in Neurological Education    Neurological
                                                                           Education


 Neurosurgery Research Group
 Prof Anthony Bell            Professor of Neurosurgery                    SAH/Brain Tumours
 Dr Marios                    Wellcome Senior Lecturer in Neurosurgery     Aquaporins
 Papadopoulos
 Mr Suresh                    September Lecturer in Neurosurgery           SAH
 Pushpananathan
 Dr Samira Saadoun            Post Doctoral Research Associate             SAH
 Dr Matthew Crocker           McKissock Clinical Lecturer                  SAH
 Dr Timothy Jones             McKissock Clinical Lecturer                  SAH
 Mr Greg Fellows              e-Tumour Clinical Research Fellow            SAH
 Mr Jonathan Bull             CRUK Lecturer in Neurosurgery                Neuro-Oncology




DETAILS OF POST

The post holder will play a role in co-ordination of studies within the Stroke Research
Group. Their primary responsibility will be to help with co-ordination of the CADISS
study but they will be expected to help with other clinical trials and studies within the
department. The main responsibilities for the CADISS (and other similar trials) are
listed below.

1. Co-ordination of the CADISS trial including;
       Maintenance of central records and database.




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            Liaising with recruiting centres to facilitate recruitment.
            Ensuring quality control both centrally and in centres according to GCP.
            Maintaining and adding records to the central database.
            Arranging transfer of study materials from recruiting centres to St
             George’s and visa versa.
            Assisting centres with ethics and R&D applications.
            Arranging regular investigators’ meetings.
            Assisting with recruitment of local patients as required.
            Keeping track of and chasing up outstanding data.
            Administering study finances and reimbursing individual centres.
            Carrying out audits and quality control checks on data quality.
            Completing annual grant and ethics committee reports.
            Liaising, and submitting data on recruitment and annual reports, to the
             Stroke Research Network.
            Writing regular study newsletters, updating the website, and
             communicating regularly with centres.
            Assisting with analysis of data and results.

2. Assisting with other clinical projects in the department particularly clinical trials.

3. Providing cross cover for other clinical trial co-ordinators when they are away on
   a reciprocal basis.

4. Participating in journal club and other activities in the department.

5. Assisting with teaching other staff within the department.



Person Specification

We are looking for a highly motivated and enthusiastic individual who is keen to work
as part of a team. They will need excellent interpersonal skills and the ability and
enthusiasm to both work with and inspire researchers from centres throughout the
UK. The post would be ideal for someone with experience of clinical trials or studies
(particularly multi-centre). Previous experience in stroke research is not essential.




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                              ST GEORGE'S, UNIVERSITY OF LONDON
                               PERSON SPECIFICATION TEMPLATE

This template shows examples of elements to include in a Person Specification. Please delete these when
using this as a template.

                         Description
 Criteria                                                               Essential/Desirable    How it is
                                                                                               to be
                                                                                               tested


 Qualifications              BSc or similar                             E                     SS, CV,
                                                                                               AF


                             Class 1 or 2.1                             D                     CV, AF

                             Relevant postgraduate training             D
                              programmes


 Experience                  Previous clinical research experience      E                     SS,
                                                                                               INT,AF,


                             Previous experience                        D                     INT, AF,
                              co-ordinating multi centre studies                               CV
                             Previous experience of working with        D
                              patients or other similar relevant
                              experience                                 D
                             Publications in scientific journals



 Knowledge/ Skills           Excellent communication and                E                     SS, INT,
                              interpersonal skills                                             AF
                             Good computer literacy                     E
                             High level of organisational skills                              SS, INT,
                                                                         E                     AF


                             GCP certificate                            D                     INT,
                                                                                               AF,CV
                             Experience of managing finances            D


 Personal                                                                E                     SS, INT,
 Attributes                  Enthusiastic & Self motivating                                   AF
                             Ability to work as part of a team and      E
                              excellent collaborative skills                                   SS, INT,
                                                                                               AF




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Key:
AF=Application Form, CV=Curriculum Vitae, SS=Supporting Statements, ST=Selection Test/Presentation,
INT=Interview

Note: Elements marked SS (Supporting Statements) in the Person Specification will be highlighted in Step 6
(Supporting Statements) on the online application form. Applicants’ answers to Step 6 are an essential part
of the selection process. Applicants should write individual supporting statements to demonstrate how their
qualifications, experience, skills and training fit each of the elements highlighted in this section. Applicants
should address other elements of the Person Specification in Step 7 (Additional Information). Shortlisting will
be based on applicants’ responses to Step 6 and Step 7. Therefore applicants should complete both sections
as fully as possible on the online application form.




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                         About St George’s, University of London

St. George’s, University of London, is the only remaining independently governed
medical school in the country. A College of the University of London, we have been
providing medical and healthcare training for over 250 years.

Our Mission is “to promote by excellence in teaching, clinical practice and research,
the prevention, treatment and understanding of disease.”

5,500 students study at St George’s, divided between two faculties, Medicine &
Biomedical Sciences, and Health & Social Care Sciences (a joint venture with
Kingston University). Our courses range from medicine, biomedical sciences,
nursing, midwifery, physiotherapy, to therapeutic and diagnostic radiography as well
as post graduate courses.

St George’s prides itself on providing the highest standard of learning through the
latest in teaching and learning resources, exceptional research, innovative course
development, enterprise and innovation, and strategic partnerships.

We were the first to introduce a 4 year MBBS Graduate Entry Programme (GEP)
open to graduates from all disciplines. Our latest Biomedical Informatics degree, a
programme that brings together computing, medicine, and biology in various different
applications, has seen significant enrolment in its inaugural year.

In research, we are equally as innovative and driven by high standards of excellence
to advance healthcare. The 4 major research themes at St George’s are Cardiac &
Vascular Sciences, Cell Signalling, Epidemiology, and Infection, including research
on HIV/AIDS, TB, Malaria, Stroke and hypertension.

St George’s success has been aided by our strategic partnerships with other
institutions. Our life-long partnership with St George’s Hospital has created a unique
learning and research environment. Our joint Faculty of Health and Social Care
Sciences, and our Foundation Year Medicine programme with Kingston University,
have significantly broadened access to medical and healthcare education for
students previously excluded from the higher education experience. And our new
three-way alliance with Kingston University and Royal Holloway, University of London
will create still more new opportunities at both the undergraduate and postgraduate
level such as the BSc in Biomedical Science.

In 2001, St George’s established an Enterprise and Innovation Centre to encourage
the transfer of knowledge and skills to business and the wider community.

St George’s academic provision is organised into 6 divisions: Basic Medical
Sciences, Cardiac and Vascular Sciences, Clinical Developmental Sciences, Cellular
and Molecular Medicine, Community Health Sciences, and Mental Health Sciences.
More information about these divisions and their research specialisms can be found
at www.sgul.ac.uk.




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Terms and Conditions of Employment (Grades 5- 8)

A full statement of the terms and conditions will be sent to the successful candidate.

Post title:                 CLINICAL TRIAL/STUDY CO-ORDINATOR (RESEARCH
                            ASSOCIATE
                            STROKE CLINICAL TRIALS GROUP

Contract type:              Fixed term for 2 years.

Probation period:           Six months

Grade:                      SGUL6

London allowance:           £2,773

Salary range:               £29,704 - £30,594 - £31,513 - £32,458 - £33,432 - £34,435 -
                            £35,469 discretionary points £36,532 - £37,651 - £38,757

                            plus £2,773 London Allowance

                            The maximum starting salary for this post is £30,594.

Hours:                      35 hours per week notionally. Staff are expected to work the
                            hours necessary to meet the requirements of the role.

Annual leave:               32 days per annum
                            Plus eight UK public holidays and three days when St
                            George’s is closed (usually between Christmas and New
                            Year). Part time staff receive a pro rata entitlement.

Pension:                    Membership of USS (Universities Superannuation Scheme,
                            employee contribution rate is 6.35%) or of SAUL
                            (Superannuation Arrangements of the University of London,
                            employee contribution rate is 6%) is optional. Existing
                            members of NHSSS (National Health Service Superannuation
                            Scheme) may elect to remain as members of that scheme.

Notice period:              3 months

Offers of                   Offers of appointment are only valid if made by the Director of
employment                  Administration or designated members of the Personnel
                            Office staff acting on his behalf.

                            Offers of appointment are made subject to receipt of
                            satisfactory references and satisfactory completion of
                            probationary periods where appropriate.

Place of residence          It is St George’s policy that all post-holders must live within 30
                            miles of St George’s on appointment unless otherwise agreed
                            by Council.

Right to work               St George’s will comply with the Asylum and Immigration Act
                            1996 which requires all employees to provide documentary
                            evidence of their legal right to work in the UK prior to



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                            commencing employment. For posts requiring a recognised
                            degree level qualification and where there is no suitable UK
                            or European Economic Area candidate, St George’s will take
                            necessary steps to secure a work permit from the Home
                            Office in order for a foreign national to take up employment.

                            All candidates invited to interview will be asked to provide
                            copies of one of the following official documents:

                                Copies of the identification pages or appropriate visa
                                 pages of their passport describing the holder as a British
                                 citizen or a EEA national or showing that they are
                                 otherwise entitled to work in the United Kingdom.
                                A birth certificate issued in the UK or in the Republic of
                                 Ireland.
                                A certificate of registration or naturalisation as a British
                                 citizen.
                                A letter issued by the Immigration and Nationality
                                 Directorate of the Home Office indicating that the person
                                 has permission to take up employment.

                            All successful candidates will be required to provide the
                            originals of one of the above documents on commencing
                            employment.

Medical Clearance           St George’s reserves the right to request successful
                            candidates (including internal candidates) to complete pre-
                            employment health questionnaires. In accordance with this,
                            any offer of employment is made subject to satisfactory health
                            clearance by the Staff Health Department.

No smoking                  St George’s has established a no-smoking policy to minimise
                            risks to the health of staff and to maintain a tobacco smoke
                            free working environment. Smoking is not permitted in any of
                            the St George’s buildings or grounds.

Equal                       St George's, University of London confirms its commitment to
Opportunities               a comprehensive policy of equal opportunities in employment
                            in which individuals are selected and treated on the basis of
                            their relevant merits and abilities and are given equal
                            opportunities within St George’s. The aim of this policy is to
                            ensure that no job applicant or employee should receive less
                            favourable treatment on any grounds not relevant to good
                            employment practice. St George’s is committed to action to
                            make this policy fully effective.




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CRB                         Criminal Records Bureau Disclosure

                            This post is subject to the successful candidate being asked
                            to apply for Disclosure from the Criminal Records Bureau
                            (CRB) at Enhanced Level Further information regarding
                            Disclosure can be found at www.disclosure.gov.uk

                            Rehabilitation of Offenders Act 1974

                            Because of the nature of the work for which you are applying,
                            this post is exempt from the provisions of Section 4(2) of the
                            Rehabilitation of Offenders Act 1974 by virtue of the
                            Rehabilitation of Offenders Act 1974 (Exceptions) Order
                            1975. Applicants are therefore not entitled to withhold
                            information about convictions, which for other purposes are
                            regarded as 'spent' under the provisions of the Act, and in the
                            event of employment, any failure to disclose such convictions
                            could result in dismissal or disciplinary action by St George's,
                            University of London. Convictions within the Armed Services,
                            outside the United Kingdom or disciplinary action by certain
                            professional bodies must also be included.

                            Any information given will be completely confidential and will
                            be considered only in relation to posts to which the Order
                            applies.


Further information about the post

Informal enquiries about the post may be made to Professor Hugh Markus, Email:
hmarkus@sgul.ac.uk, Telephone 020 8725 2735. All shortlisted applicants will be
invited to visit the department prior to interview. Unfortunately we cannot arrange
visits prior to shortlisting.

Making an application

All applicants are encouraged to apply on line at http://jobs.sgul.ac.uk as our system
is user friendly and the online application form is simple to complete.

If you do not have access to a computer with internet capability, a manual application
form can be requested from the Recruitment Team and should be returned as below:

Recruitment Team
Human Resources Department
St George's, University of London
Cranmer Terrace
London SW17 0RE,

Tel:     020 8725 5020 (24 hour answerphone)
Fax:     020 8725 3426

Email: jobs@sgul.ac.uk

Closing date: 9.00am Thursday, 27th January 2010

We shall be holding interviews on – provisional date of Friday, 12th February 2010



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As shortlisted candidates will be notified by email, it is imperative that you provide an
email address that is accessed frequently.

References will be taken up before interview unless you indicate otherwise as part of
your application.

Please quote reference         400-10.

Thank you for your interest in working at St George’s, University of London. All
applicants will be notified of the outcome of their applications by email (or by post if
no email address is supplied). We aim to respond to all candidates within 5 weeks of
the closing date of the vacancy.
.




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                                  ST George’s, University of London
                                            STAFF BENEFITS
1. Pay and Pensions

Final salary pension schemes (including option to continue existing membership of NHS pension
scheme)
         Pension Scheme             Employee’s Contribution              Employer’s Contribution
         NHSS                       6%                                   14%
         SAUL                       6%                                   13%
         USS                        6.35%                                14%
         Promotion procedure (annual) to recognise increases in responsibilities
         Merit Increments reviews (annual) to recognise and reward outstanding performance


2. Annual Leave
         Minimum entitlement of 27 days per year or maximum 32 days (pro-rata for part-time staff)
         8 Bank Holidays
         3 extra statutory days per year (normally between Christmas and New Year)


3. Work/Life Balance
         Flexible Working (part-time or reduced hours of work, opportunities to work from home for
          many posts, local flexibility in agreeing start and finish times of work)
         Generous maternity leave benefits (8 weeks full pay and 16 weeks half-pay) after completing
          one year's continuous service
         Long term sickness absence pay (rising to 6 months full pay and 6 months half pay after 5
          years' service)
         Adoption and Paternity Leave entitlements
         Paid Time Off for Dependants (compassionate leave or for domestic emergencies)
         Parental Leave
         Childcare Voucher scheme


4. Staff Development Programme
         Personal Development Review (appraisal) scheme for all staff.
         Comprehensive programme of training and development
         Management Development programme
         Learning and Teaching Support programme for teachers of students
         Dedicated programme for Research Staff, including career development, writing for publication
          and planning and managing a research project.
         Departmental and central funding for staff development
         Opportunity to achieve European Computer Driving Licence qualification


5. Trade Union and Staff Representatives
         Staff Forum for representatives of all staff groups to raise employment issues
         Formal recognition agreements with a number of trade unions


6. Staff Support
         Occupational Health Service
         Staff counselling and support service




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7. Staff Facilities
        Sports Club (gymnasium, exercise classes, four open squash courts, two aerobics room, one
         resistance machine room and one free weight rooms)
        St George’s Club, Bar and Shops
        Interest-free loans for season tickets, car parking permits and costs of training courses.




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