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                                                                                                                                 Spring 2008
                                                       C E L E B R AT I N G T E N Y E A R S I N N A PA VA L L E Y

                                                A message from the Chairman

                                                Bob Lloyd has been Chairman of The V Foundation since 1999. Bob and
                                                Jimmy V were best friends, college roommates, teammates, and served in the
                                                military together. Bob was among the group of Jim’s closest friends who

                      Keith Simmons
                                                promised him that The V Foundation would succeed and be instrumental in
                                                finding cures for cancer.

             100%                                       n behalf of the V Foundation Wine Celebration
       of V Foundation cash                             Board, I would like to invite you to the 10th
contributions and net proceeds from                     Annual Wine Celebration August 1st and 2nd in
                                                beautiful Napa Valley. The V Wine Celebration is a
 events are used for cancer research
                                                world class wine event and wine auction bringing
   and cancer-related programs.
                                                together people from the technology, sports entertain-           Bob Lloyd,
                                                                                                           V Foundation Chairman
                                                ment and wine making worlds to raise money for the
                                                fight against cancer. The V Wine Celebration is dedicated to giving back to
The V Foundation is a charitable
                                                the Napa Valley and surrounding communities that have so warmly and
organization dedicated to saving lives          enthusiastically embraced it. This year there will be a very special Fund-A-
by helping to find cures for cancer. The        Need to raise $1 million for a pediatric research grant at UCSF.
Foundation seeks to make a difference
                                                 Thanks go out to all of you for the $3.4 million that was raised at last year ’s
by generating broad-based support for
                                                V Wine Celebration. We were able to fund some very promising research in
cancer research and by creating an
                                                2007 and early 2008. Your participation again this year can make a big
urgent awareness among all Americans
                                                difference in The V Foundation’s fight to cure cancer. Since the V Foundation
of the importance of fighting cancer.
                                                Endowment is now fully funded, again thanks to your continued generosity,
The V Foundation performs these dual
                                                all of the net proceeds raised at this year ’s V Wine Celebration will be
roles through advocacy, education,              directed towards grants so that we can help find cures for cancer. There are
fundraising, and philanthropy.

                        JUST TOO GOOD TO BE TRUE:
                                                                                                                             continued on page 4

        An American Master of Pop/Rock, the Original “Jersey Boy”
        Frankie Valli & The Four Seasons to Perform Live at the 10th Anniversary Wine Celebration

                                      I  n his amazing sixth decade of stardom, Frankie Valli remains as visible and authoritative within
                                         American pop culture as ever, playing dozens of live concerts yearly, and drawing rave notices
                                      for his role in the landmark television drama The Sopranos.
                                        Now, with applause thundering nightly all around the country for the quadruple-Tony winning
                                      Broadway phenomenon Jersey Boys – currently in a twelve-city national tour, and setting up new
                                      companies in Las Vegas and London – Valli, the singular original lead voice of the iconic Four
                                      Seasons song score, has returned to the studio to create the perfect companion piece to the stage
                                         With a total of 48 Billboard Hot 100 singles between 1956 and 1994, Frankie Valli and The Four
                                      Seasons were one of the very few pre-Beatles American groups to survive the 1964 British Invasion
                                      of the American pop scene. And with the 1994 U.S. Top 20 re-charting of the No. 1 “December
                                      1963 (Oh, What a Night)” and the summer 2007 U.K. Top 40 re-charting of the 1967 hit “Beggin’,”
                                      the Four Seasons have joined a truly exclusive club, having scored major international chartings in
                                      every decade since the 1950s. The Four Seasons were inducted into the Rock and Roll Hall of
                                      Fame in 1990.
           Frankie Valli                                                                                                     continued on page 3

             V Foundation-Funded
             Researcher Focuses on
             Gynecologic Oncology
    Statistics estimate that the number of women dying
      from endometrial cancer has risen 200 percent.

                              By Paola Gherig

    M      y decision to become a gynecologic oncologist arose
           from a series of many influences. As I prepared for
    medical school, I felt destined for a career in surgery. As a                 Dr. Paola Gehrig (center) in the lab with Dr. Young Whang
    child I learned the ideal of fixing that which was broken.                                      and Dr. John Boggess.
    While in medical school, I was exposed to general surgery
    and oncology. I then had the opportunity to rotate on the            undergone organ transplantation and is also being used to coat
    gynecologic oncology service and I felt that I found my              coronary stents and subsequently decrease the risk of
    career, as these physicians performed surgery, administered          subsequent blockages. As an antineoplastic agent, rapamycin
    chemotherapy and conducted research. Over the subsequent             blocks a target (mTOR, mammalian target of rapamycin) and can
    years as I have matured as a physician, it has become clear          modulate the survival advantage that cells have as a result of
    that the ideal of “fixing” problems cannot always be attained.       PTEN mutations.
    However, within a sometimes “imperfect” outcome, I know               Our previous work suggests that the majority of endometrial
    that my efforts can help mend the lives of my patients and           cancers, including those without a PTEN mutation, may respond
    their families at an often-difficult time.                           to rapamycin. With the support of The V Foundation, we can
     My interest in endometrial carcinoma grew out of my desire          continue our work investigating rapamycin in the lab, as well as
    to help my patients. While endometrial cancer is the most            developing a clinical trial to better define the women who may
    common gynecologic malignancy in the United States, it has           benefit most from this drug. This agent, and others like it, may
    not benefited from the research interest and funding that            lead to increasing interest in targeting therapies for endometrial
    other malignancies have due to its lower mortality. However,         carcinoma and improving our success in treating this disease.
    statistics estimate that the number of women dying from              Each life is precious, and while I may not be able to “fix” the
    endometrial cancer has risen 200 percent. The current                problem that all of my patients have, I want to know and I want
    treatment modalities for endometrial cancer involve surgery,         them to know that we are doing everything possible for each and
    radiation and chemotherapy.                                          every one of them. I want to be a part of reversing the statistic of
     While we enjoy a moderate amount of success in the treat-           increasing numbers of women dying from this disease. I
    ment of this disease, all the modalities carry significant risks     appreciate The V Foundation’s support of our research and their
    and side effects. Our lab has sought to describe potential           commitment to finding a cure for cancer.
    molecular targets, which may prove beneficial with modest
    toxicities. Rapamycin, an antibiotic, has shown promise as a         Dr. Gehrig is a member of the UNC Lineberger Comprehensive Cancer
    potential antineoplastic agent. Rapamycin is currently used          Center and Assistant Professor of Gynecologic Oncology in the Department
    as an immunosuppressive agent for patients who have                  of Obstetrics and Gynecology at the UNC School of Medicine.

    Frankie Valli - continued from page 1
                                                                         a worldwide re-launch of the Four Seasons in the mid-1970s with the
       The group’s streak of hits, most of them co-written by Bob        No. 3 “Who Loves You,” and the three-week No. 1 “December 1963
    Gaudio and longtime producer Bob Crewe, began with three             (Oh What A Night),” one of the most enduring hits in Billboard history,
    consecutive No. 1 smashes, the irresistible, hard-rocking urban      with two versions logging a total 54 weeks on the pop chart. Gaudio
    cha-chas “Sherry,” “Walk Like A Man,” and “Big Girls Don’t Cry,”     was instrumental in developing the Broadway hit Jersey Boys, named
    followed by “Candy Girl.” All of them were sparked by                                 Best Musical at the 2006 Tony Awards, and he
    Valli’s powerful tenor and falsetto vocals, the                                        received the 2006 Grammy Award for Best Musical
    group’s unique fusion of street-corner doo-                                            Show Album as producer of the Broadway cast
    wop, R&B and pop choral arrangements, and                                              recording, which has topped the Billboard Top Cast
    an unerring knack for arresting lyrical hooks.                                          Album chart.
    Inspired and energized by the innovations of                                                Born in Newark, New Jersey, Frankie Valli’s trail-
    the British bands and Motown, the Four                                                  blazing journey with The Four Seasons has
    Seasons continued to post chart-topping hits                                             resulted in estimated sales of 100 million records
    through the late Sixties, conjuring indelible                                            throughout his group and solo career, with two
    images of working-class romance in ballads                                               U.S. No. 1 solo hits, 1975’s “My Eyes Adored
    and rockers like “Rag Doll,” “Big Man in                                                  You,” and the two-million-selling title song from
    Town,” “Dawn (Go Away),” “Let’s Hang On,”                            the movie Grease in 1978. Frankie also drew accolades for his
    and “Working My Way Back to You.” These, in particular, are          recurring role as wily mobster Rusty Millio on the much-lauded HBO
    acknowledged as major influences on Billy Joel, Bruce Springsteen    series The Sopranos. Now enjoying an incredible sixth decade as a
    and Bob Dylan, among many others                                     seminal force in popular music, he continues to be one of the most
       Gaudio’s songwriting partnership with Judy Parker Gaudio fueled   in-demand live performers on the road today.
                2008 Dick Vitale Gala for Cancer Research
                            A Great Success!
                                     3rd Annual Event Raises Over $1.2 million!

T    he Third Annual Dick Vitale Gala, which was held
     May 16, 2008 at Ritz-Carlton in Sarasota, Florida, was
                                                                     memory of Payton Wright.”
                                                                       “I am grateful to everyone in the Sarasota-Bradenton
officially “sold out” with over 700 guests in attendance. The        areas who has embraced this event and understands The V
Gala raised over $1.2 million to help find cures for cancer.         Foundation’s mission of funding cancer research,” said Dick
“We are thrilled and delighted that we could host a                  Vitale. “I would like to thank our phenomenal group of
capacity crowd for this great event,” said CEO of The V              sponsors and all of the celebrities who came to Sarasota to
Foundation Nick Valvano. “It is a true tribute to Dick Vitale        support Coach Knight, Coach Summitt and The V
                                      that so many of his local      Foundation. Our local friends, the sponsors who are
                                      friends, as well as national   bringing their people and their money into our area, and the
                                      sponsors, came out to          celebrities were all here for one goal - to beat cancer. The
                                      support him and his spe-       only way that will happen is with research.”
                                      cial guests Bob Knight and
                                      Pat Summitt.” The first two
                                      years of the event raised
                                      more than $1.6 million for
                                      cancer research grants
  Jimmy V and Dick Vitale at the 1993 that have been awarded to
  ESPY Awards where the formation of both the Bradenton’s All-
    The V Foundation was announced    Children’s Hospital and the
                                      Moffitt Cancer Center.
  Dick and Lorraine Vitale were the hosts for the 2007 V
Wine Celebration last August in Napa Valley. “We again
applaud Dick’s commitment and tireless efforts beneficial to
the V Foundation’s fight to find cures for cancer”, said Bob
Lloyd, Chairman of The V Foundation. “The funds donated                     V Board Members Michael Mac Donald, Dick Vitale and
at the 2008 Gala will help fund pediatric cancer research in                      Coach Pat Summit, Coach Bobby Knight

                         THE V FOUNDATION RATES FOUR STARS!

                            Fifth Consecutive 4-Star Ranking by Top Charity Evaluator
       he V Foundation for Cancer Research is in                     to efficiently manage and grow its finances,” said
       the top three percent of all charities based                  Trent Stamp, president of Charity Navigator. “Only
       on its sustained fiscal                                                       three percent of the charities we’ve
management, according to Charity                                                       rated have received at least five
Navigator, America’s premier                                                           consecutive 4-star evaluations,
evaluator of charities. The V                                                          indicating that The V Foundation
Foundation has received a top 4-star                                                   outperforms most charities in
rating from Charity Navigator for                                                      America in its efforts to operate in
the fifth consecutive period,                                                          the most fiscally responsible way
demonstrating that it has consistent-                                                  possible. This ‘exceptional’
ly outperformed most of its peers in                                                   designation from Charity
the area of fiscal responsibility.                                                     Navigator differentiates The V
“We are proud to announce The V                                                        Foundation from its peers and
Foundation has earned our fifth                                                        demonstrates to the public it is
consecutive 4-star rating for its ability                                           worthy of their trust.”
                   V Wine Celebration Raises $25 Million to Fight Cancer
                                                   Will Celebrate 10th Anniversar y in August

    T    he V Wine Celebration was founded in 1999 by
         husband and wife team Julie & Andrew
    Constantin. They set out to fight back against a
                                                                                            imagined the many friends we would make over the
                                                                                            years through our common desire to beat cancer,”
                                                                                            Andrew explained of the group of guests at the Wine
    disease that had taken the lives of loved ones.                                         Celebration last year.
    W ith a “sky’s the limit” attitude, along with                                             The V Foundation’s Endowment campaign was kicked
    generous friends and colleagues, they’ve created                                        off at our 2nd Annual event when four Founder’s Club
    one of The V Foundation’s most successful                                               pledges were received, each committing $500,000 to
    signature events. With just over 100 guests at the                                                            the endowment. In succeeding
    first event in 1999, the V Wine                                                                               years of the Wine Celebration,
    Celebration will host over 450                                                                                President’s Club members (each
    guests this August.                                                                                            pledging     $50K      to    the
      Julie and Andrew credit the                                                                                  Endowment), were moved to
    incredible generosity of the                                                                                   help, by the understanding they
    Napa Valley vintners and V                                                                                     gained about the great works of
    W ine Celebration guests for                                                                                    the V Foundation. So now that
    the event’s incredible success.                                                                                 the Endowment is complete,
    “Since the beginning, vintners                                                                                  100% of all donations and 100%
    were incredibly supportive,                                                                                      of the proceeds from every
    donating not only wine, but                                                                                      event go directly towards
    venues for dinners and experi-                                                                             cancer research.
    ences for the auction. It was                                                             “Anyone who attends the V Wine Celebration knows
    important to us to acknowledge their vital support,                                     what a unique and special event it is,” said Nick
    and giving back to the community, through V                                             Valvano, CEO of The Foundation. “The atmosphere, the
    Foundation grants, is one way we can do it,” said                                       setting and the spirit make the event the type of
    Julie Constantin. The V Wine Celebration honors                                         fundraiser people want to return to year after year.”
    one vintner each year with a Vintner’s Grant in
    acknowledgment of their support. “When we                                               At top: Nick Valvano, Andrew & Julie Constantin and Vintner Grant
                                                                                            recipients at the 2006 V Wine Celebration.
    started the event in 1999, we set out to fight a                                        Center: Debbie & Mike Tirico and Donna Orender at the
    disease that had taken so much from us. We never                                        2004 V Wine Celebration.

                                                                                Contact Us
     V Foundation . . . . . . . . . . . . . . . . . . . . . . .1-800-4jimmyv               V Foundation Wine Celebration . . . . . . . . .707-963-0611
     Fax . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .919-380-0025   Fax . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .707-581-1710
     106 Towerview Court                                                                   Reservations . . . . . . . . . . . . . . . . . . . . . . . . . .707-939-6951
     Cary, NC 27513                                                                        1127 Pope Street, Suite 203
     www.jimmyv.org                                                                        St. Helena, CA 94574
      Future Dates
          August         7   &   8,   2009
          August         5   &   6,   2010
          August         5   &   6,   2011
          August         3   &   4,   2012
          August         2   &   3,   2013
message from the Chairman - continued from page 1                  The Sullenger House at Nickel & Nickel Winery.

very few charitable foundations that can direct 100%      I’m very pleased to announce that the 2007 Vintner's
of every dollar to their programs.                       Grant in honor of Robin Lail, of Lail Vineyards was
 Our team has been working continuously since last       awarded to Ju-Seog Lee, Ph.D., at The University of
August to make this 10th Anniversary Wine                Texas, M.D. Anderson Cancer Center, Houston,
Celebration very special and exciting. The Friday        Texas. This research will characterize the interaction
night winemaker dinners will be hosted at five new       between astrocytes and cancer cells in breast cancer
and wonderful wineries providing an intimate and         brain metastasis. To learn first-hand about the
private dining experience. The Napa Valley Reserve,      progress that is being made in curing cancer, please
Cliff Lede Vineyards, Vineyard 29, Del Dotto             plan to attend the Cancer Forum on Saturday
Vineyards, and HALL Rutherford will be serving           morning at this year ’s V Wine Celebration where
exceptional gourmet dinners by top chefs with            members of the V Scientific Review Committee, who
unique wine pairings. Each winery will feature           represent the absolute best minds in cancer research,
exciting entertainers as well. And, of course, there’s   will highlight the progress in the past 12 months, in
the After Party back at the Villagio Inn!!               finding cures for cancer. Several grant recipients will
                                                         be on hand to share the progress made in their labs.
 The Nickel family has graciously and generously
                                                         Last year, over 200 of the Wine Celebration attendees
invited The V Foundation to return to enjoy the
                                                         were captivated by this discussion and Q&A session.
beautiful Nickel & Nickel Winery, where we will host
the Gala Dinner & Auction, with David Reynolds            Everyone’s commitment and inspiration, has fueled
presiding as auctioneer. I know you’ll enjoy the same    the success of the Wine Celebration and The V
wonderful outdoor ambiance that Nickel & Nickel          Foundation. Our success is not just measured in
presented last year, along with their superb single-     dollars, but also by the awareness we generate about
vineyard Nickel & Nickel wines and inviting              cancer research. Now in our second decade, The V
hospitality. This year the silent auction will be held   Foundation has raised more than $70 million and
at ground level in the winery’s second and newly         awarded more than 260 cancer research grants
constructed fermentation barn. This new space is         nationwide.
sure to add a new dimension and atmosphere to our         Finally, our success can be gauged by the wonderful
lively silent auction. We are excited to have Michael    sense of community and family we have all created
Chiarello, the renowned TV host, award-winning           together to fight this disease - a family that Jimmy
chef, and owner of NapaStyle, designing and              Valvano would be proud to call his own. There are
presiding over our menu for the Saturday evening.        more memories to be made and wonderful stories to
 Saturday evening’s entertainment on stage at Nickel     be shared. I’m looking forward to seeing you in
& Nickel will star none other than Frankie Valli &       Napa Valley for the 10th Anniversary Wine
The Four Seasons, one of the most successful and         Celebration. Don’t Give Up...Don’t Ever Give Up!
prolific American rock and pop music groups in           Kindest Regards,
history. In their long recording career, they have had
48 songs achieve Billboard’s Hot 100 singles. And of
course, Jersey Boys, based on the life and times of
Frankie Valli & The Four Seasons, has been an
exciting, highly successful, and more than entertain-
ing Broadway musical. What could be more fun?!           Chairman, V Foundation

Cancer & You                                                        • The Foundation has awarded grants to 88 institutions in 37
                                                                      states and the District of Columbia
                                                                    • The V Foundation awarded $9 million in grants in 2007.
Cancer Facts                                                          These grants fund numerous types of cancer research and
• About 1.4 million new cancer cases are expected to be               were awarded to elite researchers in 14 states.
  diagnosed in 2008. More than 20 million new cancer cases          • A $2 million grant was awarded to a ground-breaking
  have been diagnosed since 1990.                                     collaboration between Duke Comprehensive Cancer Center
• One of every two men and one out of three women will get            and UNC Lineberger Comprehensive Cancer Center for a
  cancer in their lifetimes.                                          study to individualize treatment of breast cancer
• About 565,000 Americans are expected to die of cancer in          • For the fifth consecutive year, The V Foundation for Cancer
  2008. In the U.S., cancer is the second leading cause of death,     Research has received a top 4-star rating from Charity
  responsible for 1 in 4 deaths.                                      Navigator, America’s premiere evaluator of charities. In
• Approximately 77 percent of all cancers are diagnosed in            earning Charity Navigator's highest rating, The V
  people aged 55 and older.                                           Foundation has demonstrated exceptional financial health,
                                                                      outperforming most of its peers in its efforts to manage and
V Foundation Facts                                                    grow its finances in the most fiscally responsible way
• The V Foundation for Cancer Research was founded in 1993            possible. Only three percent of the charities evaluated by
  by ESPN and the late Jim Valvano, legendary NC State                Charity Navigator have received this designation five
  basketball coach and ESPN commentator.                              consecutive years.
• The V Foundation awards 100 percent of all new direct cash        • Since 1994, The V Foundation awarded 172 V Scholar grants
  donations and net proceeds of events directly to cancer             to promising young scientists nationwide in order to help
  research and related programs.                                      them establish their laboratories. Of those V Scholars, 93
• The Foundation awards grants through a competitive awards           percent have received additional funding and are still
  process strictly supervised by a Scientific Review Committee        working in independent labs. An additional five percent are
  comprised of some of the nation’s top doctors and scientists.       currently working in related
• The V Foundation has raised more than $75 million, used to          research.
  fund cancer research grants nationwide.

    1127 Pope Street, Suite 203
       St. Helena, CA 94574

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