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									   “In the News” – January 31, 2009 – February 13, 2009 – Drug- and
    Pharmacy-related News Brought to You by the Pharmacy Library
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Basic Sciences Research

Nagahara AH, Merrill DA, Coppola G et al. Neuroprotective effects of brain-derived neurotrophic factor
in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Feb 8. [Epub ahead of print].

LiPuma JJ, Rathinavelu S, Foster BK et al. In vitro activities of a novel nanoemulsion against burkholderia
and other multidrug-resistant cystic fibrosis-associated bacterial species. Antimicrob Agents Chemother.
2009 Jan;53(1):249-55.

Lubet RA, Boring D, Steele VE et al. Lack of efficacy of the statins atorvastatin and lovastatin in rodent
mammary carcinogenesis. Cancer Prev Res (Phila Pa). 2009 Feb;2(2):161-7.

Ramagopalan SV, Maugeri NJ, Handunnetthi L et al. Expression of the multiple sclerosis-associated
MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet. 2009 Feb;5(2):e1000369.

Ren YR, Pan F, Parvez S et al. Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium
oscillation in T lymphocytes. PLoS ONE. 2008;3(12):e4009.

Ramagopalan SV, Maugeri NJ, Handunnetthi L et al. Expression of the multiple sclerosis-associated MHC
class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet. 2009 Feb;5(2):e1000369.

Samuels IS, Saitta SC, Landreth GE. MAP'ing CNS development and cognition: An ERKsome process.
Neuron. 2009 Jan 29;61(2):160-7.
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Srivastava KD, Qu C, Zhang T et al. Food allergy herbal formula-2 silences peanut-induced anaphylaxis
for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells. J Allergy Clin Immunol.
2009 Feb;123(2):443-51.

Cardiology

Messerli FH. The sudden demise of dual renin-angiotensin system blockade or the soft scienceof the
surrogate end point. J Am Coll Cardiol. 2009 Feb 10;53(6):468-70.

Juurlink DN, Gomes T, Ko DT et al. A population-based study of the drug interaction between proton
pump inhibitors and clopidogrel. CMAJ. 2009 Jan 28.

The following advisory and chart are related:

    1. Harris WS, Mozaffarian D, Rimm E et al. Omega-6 fatty acids and risk for cardiovascular disease.
       A science advisory from the American Heart Association Nutrition Subcommittee of the Council
       on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council
       on Epidemiology and Prevention. Circulation. 2009 Jan 26.

    2. Beneficial versus harmful fats. American Heart Association. January 26, 2009.

Schuster B, Regier L, Jorgenson D et al. PPIs may reduce effectiveness of clopidogrel (Plavix). Saskatoon,
SK: Rx Files; January 2009.

Briffa T, Hickling S, Knuiman M et al. Long term survival after evidence based treatment of acute
myocardial infarction and revascularisation: Follow-up of population based Perth MONICA cohort,
1984-2005. BMJ. 2009 Jan 26;338:b36.

Pallares MJ, Powers ER, Zwerner PL et al. Barriers to clopidogrel adherence following placement of
drug-eluting stents (February). Ann Pharmacother. 2009 Feb 3. [Epub ahead of print]

Shalev V, Chodick G, Silber H et al. Continuation of statin treatment and all-cause mortality: A
population-based cohort study. Arch Intern Med. 2009 Feb 9;169(3):260-8.

Ingelsson E, Massaro JM, Sutherland P et al. Contemporary trends in dyslipidemia in the Framingham
Heart Study. Arch Intern Med. 2009 Feb 9;169(3):279-86.

CAS-Related

Steinbrook R. Physician-industry relations--will fewer gifts make a difference? N Engl J Med. 2009 Feb
5;360(6):557-9.

Clauson KA, Vidal DM. Overview of biomedical journal podcasts. Am J Health Syst Pharm. 2008 Nov
15;65(22):2155-8. Review.

Coombes R. Health journalism: Two clicks away from Britney Spears? BMJ. 2009 Feb 11;338:b570.
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Kraemer JD, Gostin LO. Science, politics, and values: The politicization of professional practice
guidelines. JAMA. 2009 Feb 11;301(6):665-7.

Cerebrovascular Diseases

Rothwell PM, Giles MF, Chandratheva A et al. Early use of existing preventive strategies for Stroke
(EXPRESS) study. Effect of urgent treatment of transient ischaemic attack and minor stroke on early
recurrent stroke (EXPRESS study): A prospective population-based sequential comparison. Lancet. 2007
Oct 20;370(9596):1432-42.

CNS

Burns A, Iliffe S. Dementia. BMJ. 2009 Feb 5;338:b75.

Madhok V, Falk G, Fahey T, Sullivan FM. Prescribe prednisolone alone for Bell's palsy diagnosed within
72 hours of symptom onset. BMJ. 2009 Feb 6;338:b255.

The following article and comment are related:

    1. Cipriani A, Furukawa TA, Salanti G et al. Comparative efficacy and acceptability of 12 new-
       generation antidepressants: A multiple-treatments meta-analysis. Lancet. 2009 Jan 28.

    2. Parikh SV. Antidepressants are not all created equal. Lancet. 2009 Jan 28.

Witte AV, Fobker M, Gellner R et al. Caloric restriction improves memory in elderly humans. Proc Natl
Acad Sci U S A. 2009 Jan 27;106(4):1255-60.

Chronis-Tuscano A, Seymour KE, Stein MA et al. Efficacy of osmotic-release oral system (OROS)
methylphenidate for mothers with Attention-Deficit/Hyperactivity Disorder (ADHD): Preliminary report
of effects on ADHD symptoms and parenting. J Clin Psychiatry. 2008 Dec 2. [Epub ahead of print]

Kendall T, Pilling S, Tyrer P et al. Guideline Development Groups. Borderline and antisocial personality
disorders: Summary of NICE guidance. BMJ. 2009 Jan 28;338:b93.

Torpy JM, Lynm C, Glass RM. JAMA patient page. Bipolar disorder. JAMA. 2009 Feb 4;301(5):564.

Lee JJ, Erdos J, Wilkosz MF et al. Bupropion as a possible treatment option for Restless Legs Syndrome
(February). Ann Pharmacother. 2009 Feb 3. [Epub ahead of print]

Schroeder SA. A 51-year-old woman with bipolar disorder who wants to quit smoking. JAMA. 2009 Feb
4;301(5):522-31.

aan het Rot M, Mathew SJ, Charney DS. Neurobiological mechanisms in major depressive disorder.
CMAJ. 2009 Feb 3;180(3):305-13.

The following article and comment are related:

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        1. Rajaratnam SM, Polymeropoulos MH, Fisher DM et al. Melatonin agonist tasimelteon (VEC-
           162) for transient insomnia after sleep-time shift: Two randomised controlled multicentre
           trials. Lancet. 2008 Dec 1. [Epub ahead of print]

        2. Cardinali DP, Golombek DA. Let there be sleep-on time. Lancet. 2008 Dec 1. [Epub ahead of
           print]

Scarmeas N, Stern Y, Mayeux R et al. Mediterranean diet and mild cognitive impairment. Arch Neurol.
2009 Feb;66(2):216-25.

The following editorial and two studies are related:

    1. Schneck CD. Mixed depression: The importance of rediscovering subtypes of mixed mood
       States. Am J Psychiatry. 2009 Feb;166(2):127-30.

    2. Frye MA, Helleman G, McElroy SL et al. Correlates of treatment-emergent mania associated
       with antidepressant treatment in bipolar depression. Am J Psychiatry. 2009 Feb;166(2):164-72.
       Epub 2008 Nov 17.

    3. Goldberg JF, Perlis RH, Bowden CL et al. Manic symptoms during depressive episodes in 1,380
       patients with bipolar disorder: Findings from the STEP-BD. Am J Psychiatry. 2009
       Feb;166(2):173-81. Epub 2009 Jan 2.

Connective Tissue Diseases

Wentworth J, Davies C. Systemic lupus erythematosus. Nat Rev Drug Discov. 2009 Feb;8(2):103-4.

Diabetes

Ferrannini E, Fonseca V, Zinman B et al. Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride
in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes
Obes Metab. 2009 Feb;11(2):157-66.
(Vildagliptan is not marketed in Canada.)

Shah NR, Hirsch AG, Zacker C et al. Factors associated with first-fill adherence rates for diabetic
medications: A cohort study. J Gen Intern Med. 2009 Feb;24(2):233-7.

The following article and comment are related:

        1. Garber A, Henry R, Ratner R et al.; for the LEAD-3 (Mono) Study Group. Liraglutide versus
           glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week,
           phase III, double-blind, parallel-treatment trial. Lancet. 2008 Sep 24. [Epub ahead of print]

        2.   Madsbad S. Treatment of type 2 diabetes with incretin-based therapies. Lancet. 2008 Sep
             24. [Epub ahead of print]

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Xu W, Qiu C, Gatz M et al. Mid- and late-life diabetes in relation to the risk of dementia: A population-
based twin study. Diabetes. 2009 Jan;58(1):71-7.

Dermatology

Metz N. Building a better eyelash: A look at the newest cosmetic wonder drug from the botox folks.
Chicago Tribune. 2009 Feb 8.

Drug Compounding & Biopharmaceutics

Junker A, Roy S, Desroches MC et al. Stability of oxaliplatin solution (February). Ann Pharmacother.
2009 Feb 3. [Epub ahead of print]

Media release: Major formulation breakthrough for loratadine the leading oral allergy medication.
Washington DC: Strategic Bio Sciences; January 29, 2009.

Dentinger PJ, Swenson CF. Stability of reconstituted fluconazole oral suspension in plastic bottles and
oral syringes(March). Ann Pharmacother. 2009 Feb 10.

Savica V, Calò LA, Monardo P et al. Salivary phosphorus and phosphate content of beverages:
Implications for the treatment of uremic hyperphosphatemia. J Ren Nutr. 2009 Jan;19(1):69-72.

Drug Safety

Golomb BA, Evans MA. Statin adverse effects: A review of the literature and evidence for a
mitochondrial mechanism. Am J Cardiovasc Drugs. 2008;8(6):373-418.

Frumin J, Gallagher JC. Allergic cross-sensitivity between penicillin, carbapenem, and monobactam
antibiotics: What are the chances? (February) (CE). Ann Pharmacother. 2009 Feb 5.

Tilstone C. Drug safety update: latest advice for all medicines users. UK: Medicines and Healthcare
products Regulatory Agency and the Commission on Human Medicines; February 2009.

Gerber JS, Offit PA. Vaccines and autism: A tale of shifting hypotheses. Clin Infect Dis. 2009 Jan 7.
[Epub ahead of print]

The following is a study and related editorial:

        1. Barbui C, Esposito E, Cipriani A . Selective serotonin reuptake inhibitors and risk of suicide:
           A systematic review of observational studies. CMAJ. 2009 Feb 3;180(3):291-7.

        2. Gibbons R, Mann JJ. Proper studies of selective serotonin reuptake inhibitors are needed
           for youth with depression. CMAJ. 2009 Feb 3;180(3):270-1.

Jackson G. Faking it: The dangers of counterfeit medicine on the internet. Int J Clin Pract. 2009
Feb;63(2):181.

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The New York Times article listed below refers to the FDA document that follows:

Harris G. F.D.A. to place new limits on prescriptions of narcotics. New York Times. February 10, 2009.

FDA to meet with drug companies about REMS for certain opioid drugs. Rockville MD. US FDA.
February 9, 2009.

Feinmann J. Safety first. BMJ. 2009 Feb 6;338:b420.

Environmental Concerns

Arif AA, Delclos GL, Serra C. Occupational exposures and asthma among nursing professionals. Occup
Environ Med. 2009 Jan 22.

Orenstein P. The way we live now: The toxic paradox. New York Times. February 8, 2009.

Fibromyalgia

Sipkoff M. Fibromyalgia coverage uneven despite recent drug approvals. Manag Care. 2008
Dec;17(12):9-10.

Gastrointestinal Diseases

Bhardwaj P, Garg PK, Maulik SK et al. A randomized controlled trial of antioxidant supplementation for
pain relief in patients with chronic pancreatitis. Gastroenterology. 2009 Jan;136(1):149-159.e2.

Geriatrics

Bartlett G, Abrahamowicz M, Grad R et al. Association between risk factors for injurious falls and new
benzodiazepine prescribing in elderly persons. BMC Fam Pract. 2009 Jan 6;10:1.

ICU

The following is a study and related editorial:

        1. Riker RR, Shehabi Y, Bokesch PM et al.; SEDCOM (Safety and Efficacy of Dexmedetomidine
           Compared With Midazolam) Study Group. Dexmedetomidine vs midazolam for sedation of
           critically ill patients: A randomized trial. JAMA. 2009 Feb 4;301(5):489-99.

        2. Wunsch H, Kress JP. A new era for sedation in ICU patients. JAMA. 2009 Feb 4;301(5):542-
           4.

Immune System Diseases

Engler RJ, Gregory PJ, Jellin JM. Complementary and alternative medicine for the allergist-
immunologist: Where do I start? J Allergy Clin Immunol. 2009 Feb;123(2):309-16.


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Mainardi T, Kapoor S, Bielory L. Complementary and alternative medicine: Herbs, phytochemicals and
vitamins and their immunologic effects. J Allergy Clin Immunol. 2009 Feb;123(2):283-94; quiz 295-6.

Infectious Diseases

Klass P. The cough-and-sniffle question: When to keep a child at home? New York Times. February 10,
2009.

Arias CA, Murray BE. Antibiotic-resistant bugs in the 21st century--a clinical super-challenge. N Engl J
Med. 2009 Jan 29;360(5):439-43.

The following is a study and related comment:

        1. Ota KV, Jamieson F, Fisman DN et al. Prevalence of and risk factors for quinolone-resistant
           Neisseria gonorrhoeae infection in Ontario. CMAJ. 2009 Feb 3;180(3):287-90.

        2. Tapsall J. Multidrug-resistant Neisseria gonorrhoeae. CMAJ. 2009 Feb 3;180(3):268-9.

Deeks SG, Phillips AN. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.
BMJ. 2009 Jan 26;338:a3172.

Kidney Diseases

Sullivan C, Sayre SS, Leon JB et al. Effect of food additives on hyperphosphatemia among patients with
end-stage renal disease: A randomized controlled trial. JAMA. 2009 Feb 11;301(6):629-35.

Drawz P, Rahman M. In the clinic. Chronic kidney disease. Ann Intern Med. 2009 Feb 3;150(3):ITC2-1-
15; quiz ITC2-16.

Men’s Health

Nuzzo R. Preventing penile fractures and Peyronie’s disease. Los Angeles Times. February 9, 2009.

Heppner PS, Crawford EF, Haji UA et al. The Association of Posttraumatic Stress Disorder and Metabolic
Syndrome: A study of increased health risk in veterans. BMC Med. 2009 Jan 9;7(1):1. [Epub ahead of
print]

Brisinda G, Cadeddu F, Vanella S et al. Relief by botulinum toxin of lower urinary tract symptoms owing
to benign prostatic hyperplasia: Early and long-term results. Urology. 2009 Jan;73(1):90-4. Epub 2008
Nov 8.

News – Canada

Rochon L. Hey dude, check out the flower power: The U of Waterloo has wrapped its new School of
Pharmacy in medicinal herbs. The result isn’t flawless, but sure is groovy. Globe and Mail. January 24,
2009.

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Blackwell T. Ontario aims to counter drug firm sales pitches. National Post. January 29, 2009.

Hébert PC, Stanbrook MB, Flegel K et al. The budget's message to medical science: Quick! Get a shovel!
CMAJ. 2009 Feb 5.

News – International

Kresge N. MS prize of $1.3 billion spurs Merck KGaA, Novartis (Update 1). Bloomberg.com. February
13, 2009.

Deer B. MMR doctor Andrew Wakefield fixed data on autism. Sunday Times [London]. February 8,
2009.

‘Virtual patient’ helps train pharmacists of the future. ScienceDaily. January 22, 2009.

News release: How fake drugs got into the NHS. UK: BBC News; February 3, 2009.

News release: WHO receives funds for children's medicines research with UNICEF US$ 9.7 million grant
from Gates Foundation to help crucial research on children's medicines. World Health Organization.
January 21, 2009.

News – Regional

Erskine B. C.B. could produce Alzheimer’s treatment. Chronicle Herald. February 12, 2009.

News – US

Perrone M. Drugmakers add to buzz on disease that may not be real. Houston Chronicle. February 8,
2009.

Japsen B. Pfizer’s future tied to biotechnology: New outlook coincides with last month’s deal to acquire
Wyeth. Chicagotribune.com. February 12, 2009.

Singer N. Vanity’s downturn: Botox use, and Allergan sales, dip. New York Times. February 5, 2009.

Kam D. Lawmaker’s measure would drive drug ID business to one firm. PalmBeachPost.com. February
5, 2009.

Steenhuysen J. U.S. psychiatrists may cut some ties to drug firms. Reuters. February 8, 2009.

Landro L. Incentives push more doctors to e-prescribe: electronic systems shown to reduce dangerous
errors; a cure for poor penmanship. The Wall Street Journal. January 21, 2009.

Wangsness L. A battle over mail-order drugs: savings and effectiveness debated. The Boston Globe.
February 2, 2009.



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Boyle M. CVS’s bold bet on health-care reform: The CEO of CVS/Caremark says getting patients to stick
to their drug regimens would save billions in medical care. Health-care reformers are listening.
BusinessWeek. February 12, 2009.

The next two articles from the New York Times are related:

    1. McNeil DG Jr. Court says vaccine not to blame for autism. New York Times. February 13, 2009.

    2. Editorial: Vaccines exonerated on autism. New York Times. February 13, 2009.

Abelson R, Pollack A. Medicare widens drugs it accepts for cancer. New York Times. January 27, 2009.

Chan S. City unveils Facebook page to encourage condom use. New York Times. February 12, 2009.

Singer N. Bristol-Myers’s reliance on three drugs casts doubt on strategy, New York Times. January 28,
2009.

Sorkin AR, Wilson D. Pfizer agrees to $68 billion deal for Wyeth. New York Times. January 26, 2009.

Singer N. A birth control pill that promised too much. New York Times. February 11, 2009.

Lavoie D, Contreras R. FBI takes sudden new interest in “Tylenol Man”. New York Times. February 5,
2009.

Pollack A. FDA approves drug from gene-altered goats. New York Times. February 7, 2009.

Money P. Strategies for saving on prescription drugs. New York Times. February 7, 2009.

Obesity & Eating Disorders

Stothard KJ, Tennant PW, Bell R et al. Maternal overweight and obesity and the risk of congenital
anomalies: a systematic review and meta-analysis. JAMA. 2009 Feb 11;301(6):636-50.

Oude Luttikhuis H, Baur L, Jansen H et al. Interventions for treating obesity in children. Cochrane
Database Syst Rev. 2009 Jan 21;(1):CD001872.

Attia E, Walsh BT. Behavioral management for anorexia nervosa. N Engl J Med. 2009 Jan
29;360(5):500-6.

Tuomilehto HP, Seppa JM, Partinen MM et al. Lifestyle Intervention with Weight Reduction-First Line
Treatment in Mild Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2008 Nov 14.

Ludwig DS, Pollack HA. Obesity and the economy: from crisis to opportunity. JAMA. 2009 Feb
4;301(5):533-5.




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Kremer R, Campbell PP, Reinhardt T, Gilsanz V. Vitamin D status and its relationship to body fat, final
height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009 Jan;94(1):67-73. Epub 2008
Nov 4.

Teff KL, Grudziak J, Townsend RR et al. Endocrine and metabolic effects of consuming fructose- and
glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on
plasma triglyceride responses. J Clin Endocrinol Metab. 2009 Feb 10. [Epub ahead of print]

Obstetrics and Gynecology

Gruslin A, Steben M, Halperin S et al. Immunization in pregnancy. J Obstet Gynaecol Can. 2008
Dec;30(12):1155-62.

Reichmann JP, Kirkbride MS. Nausea and vomiting of pregnancy: cost effective pharmacologic
treatments. Manag Care. 2008 Dec;17(12):41-5. Review.

Shennan AH, Chandiramani M. Antibiotics for spontaneous preterm birth. BMJ. 2008 Dec
30;337:a3015.

Doyle LW, Crowther CA, Middleton P et al. Magnesium sulphate for women at risk of preterm birth for
neuroprotection of the fetus. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004661.

Smedts HP, de Vries JH, Rakhshandehroo Met al. High maternal vitamin E intake by diet or supplements
is associated with congenital heart defects in the offspring. BJOG. 2009 Feb;116(3):416-23.

Oncology

Goldman B, DeFrancesco L. The cancer vaccine roller coaster. Nat Biotechnol. 2009 Feb;27(2):129-39

Daling JR, Doody DR, Sun X et al. Association of marijuana use and the incidence of testicular germ cell
tumors. Cancer. 2009 Feb 9.

The following article and editorial are related:

    1. Jensen A, Sharif H, Frederiksen K et al. Use of fertility drugs and risk of ovarian cancer: Danish
       Population Based Cohort Study. BMJ. 2009 Feb 5;338:b249.

    2. Webb PM. Fertility drugs and ovarian cancer. BMJ. 2009 Feb 5;338:a3075.

OTCs, Nutrion, NHPs, Lifestyle, etc.

News: Report card on health: Heart and Stroke Foundation report asks: What’s in store for Canada’s
heart health? New report reveals big inconsistencies in price and accessibility of healthy food across
Canada. Toronto ON: Heart & Stroke Foundation; [February] 2009.



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Erickson BE. Nanoceuticals: Dietary supplements made with nanotechnology are hitting the market
with little government. Chem Eng News. 2009 Feb 9; [epub ahead of print].

Flegel K, Magner P. Get excess salt out of our diet. CMAJ. 2009 Feb 3;180(3):263, 265. English, French.

Martin L, Zarn D, Hansen AM et al. Food products as vehicles for n-3 fatty acid supplementation. Can J
Diet Pract Res. 2008 Winter;69(4):203-7.

Dobbins M, De Corby K, Robeson P et al. School-based physical activity programs for promoting physical
activity and fitness in children and adolescents aged 6-18. Cochrane Database Syst Rev. 2009 Jan
21;(1):CD007651.

Raynor HA, Jelalian E, Vivier PM, Hart CN, Wing RR. Parent-reported eating and leisure-time activity
selection patterns related to energy balance in preschool- and school-aged children. J Nutr Educ Behav.
2009 Jan-Feb;41(1):19-26.

Lauder RM. Chondroitin sulphate: a complex molecule with potential impacts on a wide range of
biological systems. Complement Ther Med. 2009 Jan;17(1):56-62. Epub 2008 Nov 26. Review.

Neuhouser ML, Wassertheil-Smoller S, Thomson C et al. Multivitamin use and risk of cancer and
cardiovascular disease in the Women's Health Initiative cohorts. Arch Intern Med. 2009 Feb
9;169(3):294-304.

The following article and editorial are related:

    1. Keenan PS. Smoking and weight change after new health diagnoses in older adults. Arch Intern
       Med. 2009 Feb 9;169(3):237-42.

    2. Pagoto S, Ockene J. Windows of opportunity for smoking and weight loss counseling. Arch
       Intern Med. 2009 Feb 9;169(3):217-8.

Roemer EC, Craun BA, Tully KJ et al. First-Year Results of an Obesity Prevention Program at The Dow
Chemical Company. J Occup Environ Med. 2009 Feb;51(2):125-138.

Martin CK, Church TS, Thompson AM et al. Exercise dose and quality of life: a randomized controlled
trial. Arch Intern Med. 2009 Feb 9;169(3):269-78.

Donnelly JE, Blair SN, Jakicic JM et al; American College of Sports Medicine. American College of Sports
Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and
prevention of weight regain for adults. Med Sci Sports Exerc. 2009 Feb;41(2):459-71.

Brody JE. America’s diet: too sweet by the spoonful. New York Times. February 10, 2009.

Weeks C. Chocolate: It's just not that good for you. Globe and Mail. February 12, 2009.



                                                                                                       11
Pain and Palliative Care

The following article and editorial are related:

    1. Madsen MV, Gøtzsche PC, Hróbjartsson A. Acupuncture treatment for pain: systematic review
       of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture
       groups. BMJ. 2009 Jan 27;338:a3115.

    2. White A, Cummings M. Does acupuncture relieve pain? BMJ. 2009 Jan 27;338:a2760.

The following three articles are related:

    1. Chou R, Fanciullo GJ, Fine PG et al. American Pain Society-American Academy of Pain Medicine
       Opioids Guidelines Panel. Clinical guidelines for the use of chronic opioid therapy in chronic
       noncancer pain. J Pain. 2009 Feb;10(2):113-30.

    2. Chou R, Fanciullo GJ, Fine PG et al. Opioids for chronic noncancer pain: prediction and
       identification of aberrant drug-related behaviours: a review of the evidence for an American
       Pain Society and American Academy of Pain Medicine clinical practice guideline. J Pain. 2009
       Feb;10(2):131-46.

    3. Chou R, Ballantyne JC, Fanciullo GJ et al. Research gaps on use of opioids for chronic noncancer
       pain: findings from a review of the evidence for an American Pain Society and American
       Academy of Pain Medicine clinical practice guideline. J Pain. 2009 Feb;10(2):147-59.

Pediatrics

The following 2 articles and editorial are related:

    1. Vlasselaers D, Milants I, Desmet L et al. Intensive insulin therapy for patients in paediatric
       intensive care: a prospective, randomised controlled study. Lancet. 2009 Jan 26.

    2. Ducharme FM, Lemire C, Noya FJ et al. Preemptive use of high-dose fluticasone for virus-
       induced wheezing in young children. N Engl J Med. 2009 Jan 22;360(4):339-53.

    3. Bush A. Practice imperfect--treatment for wheezing in preschoolers. N Engl J Med. 2009 Jan
       22;360(4):409-10.

Doyle LW, Crowther CA et al. Magnesium sulphate for women at risk of preterm birth for
neuroprotection of the fetus. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004661.

Schwartz GJ, Muñoz A, Schneider MF et al. New Equations to Estimate GFR in Children with CKD. J Am
Soc Nephrol. 2009 Jan 21.




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Shaikh U, Byrd RS, Auinger P. Vitamin and mineral supplement use by children and adolescents in the
1999-2004 National Health and Nutrition Examination Survey: relationship with nutrition, food security,
physical activity, and health care access. Arch Pediatr Adolesc Med. 2009 Feb;163(2):150-7.

Zaoutis T, Localio AR, Leckerman K et al. Prolonged intravenous therapy versus early transition to oral
antimicrobial therapy for acute osteomyelitis in children. Pediatrics. 2009 Feb;123(2):636-42.

Pharmacogenetics

The following 2 articles and editorial are related:

    1. Simon T, Verstuyft C, Mary-Krause M et al; French Registry of Acute ST-Elevation and Non-ST-
       Elevation Myocardial Infarction (FAST-MI) Investigators. Genetic determinants of response to
       clopidogrel and cardiovascular events. N Engl J Med. 2009 Jan 22;360(4):363-75.

    2. Mega JL, Close SL, Wiviott SD et al. Cytochrome p-450 polymorphisms and response to
       clopidogrel. N Engl J Med. 2009 Jan 22;360(4):354-62. Epub 2008 Dec 22.

    3. Freedman JE, Hylek EM. Clopidogrel, genetics, and drug responsiveness. N Engl J Med. 2009 Jan
       22;360(4):411-3.

Nelson MR, Bacanu SA, Mosteller M et al. Genome-wide approaches to identify pharmacogenetic
contributions to adverse drug reactions. Pharmacogenomics J. 2009 Feb;9(1):23-33.

Respiratory Diseases

de Lange EE, Altes TA, Patrie JT et al. Changes in regional airflow obstruction over time in the lungs of
patients with asthma: evaluation with 3He MR imaging. Radiology. 2009 Feb;250(2):567-75.
(Per the authors: “The persistence of regional airflow impediment is independent of disease severity
and the use of asthma medications.”)

Gerald LB, McClure LA, Mangan JM et al. Increasing adherence to inhaled steroid therapy among
schoolchildren: randomized, controlled trial of school-based supervised asthma therapy. Pediatrics.
2009 Feb;123(2):466-74.

Singh S, Amin AV, Loke YK. Long-term use of inhaled corticosteroids and the risk of pneumonia in
chronic obstructive pulmonary disease: a meta-analysis. Arch Intern Med. 2009 Feb 9;169(3):219-29.

Rheumatology

Burner TW, Rosenthal AK. Diabetes and rheumatic diseases. Curr Opin Rheumatol. 2009 Jan;21(1):50-4.

Socioeconomic Topics

The January 31, 2009 issue of BMJ includes several commentaries in honor of the 10th “birthday” of
NICE, the National Institute for Health and Clinical Excellence. NICE conducts HTAs which determine the
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drugs that are paid for by the UK NHS, making NICE very influential; some of their decisions have been
controversial:

Drummond M, Mason A. Rationing new medicines in the UK. BMJ. 2009 Jan 22;338:a3182.

Hawkes N. NICE goes global. BMJ. 2009 Jan 28;338:b103.

Towse A. Should NICE's threshold range for cost per QALY be raised? Yes. BMJ. 2009 Jan 26;338:b181.

Raftery J. Should NICE's threshold range for cost per QALY be raised? No. BMJ. 2009 Jan 26;338:b185.

Raftery J. NICE and the challenge of cancer drugs. BMJ. 2009 Jan 13;338:b67.

Speight J, Reaney M. Rationing: Wouldn’t it be NICE to consider patients’ views when rationing health
care? BMJ. 2009 Jan 13; [epub ahead of print].

Tannen RL, Weiner MG, Xie D. Use of primary care electronic medical record database in drug efficacy
research on cardiovascular outcomes: comparison of database and randomised controlled trial findings.
BMJ. 2009 Jan 27;338:b81.

A recent report from the Royal College of Physicians inspired an editorial plus five analyses in the
February 7, 2009 issue of BMJ:

Innovating for health: Patients, physicians, the pharmaceutical industry and the NHS: Report of a
working party. London: Royal College of Physicians; February 2009.

Collier J. Doctors, patients, and the pharmaceutical industry. BMJ. 2009 Feb 3;338:b443.

Krumholz HM, Ross JS. Relationships with the drug industry: More regulation, greater transparency.
BMJ. 2009 Feb 3;338:b211.

Coutts G. Relationships with the drug industry: Collaboration to improve care. BMJ. 2009 Feb
3;338:b232.

Tiner R. Relationships with the drug industry: Focus on better information. BMJ. 2009 Feb 3;338:b252.

Angell M. Relationships with the drug industry: Keep at arm's length. BMJ. 2009 Feb 3;338:b222.

Gottlieb S. Relationships with the drug industry: Build trust based on good science. BMJ. 2009 Feb
3;338:b234.

Bach PB. Limits on Medicare's Ability to Control Rising Spending on Cancer Drugs. N Engl J Med. 2009
Jan 28.

Frank C, Nason E. Health research: measuring the social, health and economic benefits. CMAJ. 2009 Jan
22.

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The following article and editorial are related:

    1. Amarasingham R, Plantinga L, Diener-West M et al. Clinical information technologies and
       inpatient outcomes: a multiple hospital study. Arch Intern Med. 2009 Jan 26;169(2):108-14.

    2. Bates DW. The effects of health information technology on inpatient care. Arch Intern Med.
       2009 Jan 26;169(2):105-7.

Thomson MS, Gruneir A, Lee M et al. Nursing Time Devoted to Medication Administration in Long-Term
Care: Clinical, Safety, and Resource Implications. J Am Geriatr Soc. 2008 Dec 11.

Elsom S, Happell B, Manias E. Nurse practitioners and medical practice: opposing forces or
complementary contributions? Perspect Psychiatr Care. 2009 Jan;45(1):9-16.

The following study and comment are related:

    1. Thornicroft G, Brohan E, Rose D et al; INDIGO Study Group. Global pattern of experienced and
       anticipated discrimination against people with schizophrenia: a cross-sectional survey. Lancet.
       2009 Jan 31;373(9661):408-15.

    2. Schulze B. Mental-health stigma: expanding the focus, joining forces. Lancet. 2009 Jan
       31;373(9661):362-3. Epub 2009 Jan 21.

Jack A. Radical treatments for difficult times. BMJ. 2009 Jan 13;338:a2955.

The following article and news report are related:

    1. Rupp MT, Warholak TL. Evaluation of e-prescribing in chain community pharmacy: best-practice
       recommendations. J Am Pharm Assoc (2003). 2008 May-Jun;48(3):364-70.

    2. Meier B. New rules on doctors and medical firms amid ethics concerns. New York Times. January
       24, 2009.

Skinner BJ, Gray JR, Attara GP. Increased health costs from mandated Therapeutic Substitution of
proton pump inhibitors in British Columbia. Aliment Pharmacol Ther. 2009 Jan 17.

The worst of times, the best of times. Nat Biotechnol. 2009 Feb;27(2):101.

Isaac T, Weissman JS, Davis RB et al. Overrides of medication alerts in ambulatory care. Arch Intern
Med. 2009 Feb 9;169(3):305-11.

Mansur N, Weiss A, Beloosesky Y. Is There an Association Between Inappropriate Prescription Drug Use
and Adherence in Discharged Elderly Patients? (February). Ann Pharmacother. 2009 Feb 3.

Bach PB. Limits on Medicare's ability to control rising spending on cancer drugs. N Engl J Med. 2009 Feb
5;360(6):626-33. Epub 2009 Jan 27.

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Nahata MC. Thoughts on Teaching and Learning (February). Ann Pharmacother. 2009 Feb 3.

Woolf SH. A closer look at the economic argument for disease prevention. JAMA. 2009 Feb
4;301(5):536-8.

Tannen RL, Weiner MG, Xie D. Use of primary care electronic medical record database in drug efficacy
research on cardiovascular outcomes: comparison of database and randomised controlled trial findings.
BMJ. 2009 Jan 27;338:b81.

Collier R. Drug development cost estimates hard to swallow. CMAJ. 2009 Feb 3;180(3):279-80.

Collier R. Rapidly rising clinical trial costs worry researchers. CMAJ. 2009 Feb 3;180(3):277-8.

Jack BW, Chetty VK, Anthony D et al. A reengineered hospital discharge program to decrease
rehospitalisation: a randomized trial. Ann Intern Med. 2009 Feb 3;150(3):178-87.

Stats & Facts

Stagnitti MN. Trends in outpatient prescription analgesics utilization and expenditures for the U.S.
civilian noninstitutionalized population, 1996 and 2006. [MEPS] Statistical Brief [US AHRQ; Rockville
MD]. 2009 Feb; #235:1-8.

Prescription drug trends. Menlo Park CA: Kaiser Family Foundation; September 2008, 1-6.

Soni A. The top five therapeutic classes of outpatient prescription drugs ranked by total expense for
adults age 18 and older in the U.S. civilian non-institutionalized population, 2006. [MEPS] Statistical
Brief [US AHRQ; Rockville MD]. 2009 Jan;#232; 1-6.

Felland LE, Reschovsky JD. More nonelderly American face problems affording prescription drugs.
Tracking Report [Center for Studying Health System Change; Washington DC]. 2009 Jan;No.22:[1-4].

Substance Use & Substance Use-Related Disorders

Zhu SH, Wang JB, Hartman A et al. Quitting Cigarettes Completely or Switching to Smokeless: Do U.S.
Data Replicate the Swedish Results? Tob Control. 2009 Jan 23.

Hajek P, Stead LF, West R et al. Relapse prevention interventions for smoking cessation. Cochrane
Database Syst Rev. 2009 Jan 21;(1):CD003999.

Schuckit MA. Alcohol-use disorders. Lancet. 2009 Jan 22.

Okie S. The epidemic that wasn’t. New York Times. January 27, 2009.

Barclay L. Safety guidelines issued for prescribing methadone. Medscape Medical News; February 2009.
(Medscape is free but requires registration)


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Salize HJ, Merkel S, Reinhard I et al. Cost-effective primary care-based strategies to improve smoking
cessation: more value for money. Arch Intern Med. 2009 Feb 9;169(3):230-5; discussion 235-6.

Dent LA, Harris KJ, Noonan CW. Randomized Trial Assessing the Effectiveness of a Pharmacist-Delivered
Program for Smoking Cessation (February). Ann Pharmacother. 2009 Feb 3.

Nicosia N, Pacula RL et al. The economic cost of methamphetamine use in the United States, 2005.
Santa Monica CA: RAND Drug Policy Research Center; 2009.

The following press release and position statement are related:

    1. News release: The Endocrine Society re-issues position statement on steroid abuse. Chevy
       Chase MD: The Endocrine Society; February 10, 2009.

    2. Position statement: Steroid abuse. Chevy Chase MD: The Endocrine Society; June 2008.

Holtgrave DR, Wunderink KA, Vallone DM et al. Cost-utility analysis of the National truth ((R)) Campaign
to prevent youth smoking. Am J Prev Med. 2009 Feb 9. [Epub ahead of print]

Surgery, Transplantation, and Anaesthesia

O'Riordan JM, Margey RJ, Blake G et al. Antiplatelet agents in the perioperative period. Arch Surg. 2009
Jan;144(1):69-76; discussion 76.

de Lange DW, Kars M. Perioperative glucocorticosteroid supplementation is not supported by evidence.
Eur J Intern Med. 2008 Oct;19(6):461-7. Epub 2008 Feb 4. Review.

Urologic Diseases

Onwude JL. What is the most effective treatment of interstitial cystitis? BMJ. 2008 Nov 27;337:a2325.

Nickel JC, Egerdie B, Downey J et al. A real-life multicentre clinical practice study to evaluate the efficacy
and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis. BJU Int. 2009
Jan;103(1):56-60.

Women’s Health

Subak LL, Wing R, West DS et al.; PRIDE Investigators. Weight loss to treat urinary incontinence in
overweight and obese women. N Engl J Med. 2009 Jan 29;360(5):481-90.

Eliassen AH, Chen WY, Spiegelman D et al. Use of aspirin, other nonsteroidal anti-inflammatory drugs,
and acetaminophen and risk of breast cancer among premenopausal women in the Nurses' Health Study
II. Arch Intern Med. 2009 Jan 26;169(2):115-21; discussion 121.

The following article and comment are related:


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    1. Grossman D. Should the contraceptive pill be available without prescription? Yes. BMJ. 2008
       Dec 23;337:a3044.

    2. Jarvis S. Should the contraceptive pill be available without prescription? No. BMJ. 2008 Dec
       23;337:a3056.

Carbone LD, Johnson KC, Bush AJ et al. Loop diuretic use and fracture in postmenopausal women:
findings from the Women's Health Initiative. Arch Intern Med. 2009 Jan 26;169(2):132-40.

Bio-identicals: sorting myths from facts. US FDA Consumer Health Information. April 8, 2008.

Guilbert ER, Brown JP, Kaunitz AM et al. The use of depot-medroxyprogesterone acetate in
contraception and its potential impact on skeletal health. Contraception. 2009 Mar;79(3):167-77.

Silverman BG, Kokia ES. Use of Hormone Replacement Therapy, 1998-2007: Sustained Impact of the
Women's Health Initiative Findings (February). Ann Pharmacother. 2009 Feb 5.

By and About Faculty, Students, Alumni, & Friends

Sketris IS, Langille Ingram EM, Lummis HL. Strategic opportunities for effective optimal prescribing and
medication management. Can J Clin Pharmacol. 2009 Winter;16(1):e103-25.

Nemetz A. Searching for personality: if you’re model material you’re tall, lean and photogenic, too. The
Chronical Herald. January 23, 2009.
(Third-year Dalhousie pharmacy student Melissa White was featured in this article.)

Zed PJ, Abu-Laban RB, Shuster Met al. Update on cardiopulmonary resuscitation and emergency
cardiovascular care guidelines. Am J Health Syst Pharm. 2008 Dec 15;65(24):2337-46. Review.

Mackinnon NJ, Ip I. The National Pharmaceuticals Strategy: Rest in peace, revive or renew? CMAJ. 2009
Feb 3. [Epub ahead of print]

. . . refers to the following two reports:

A status report on the national pharmaceutical strategy: A prescription unfilled. Toronto ON: Health
Council of Canada; January 2009.

A commentary on the national pharmaceutical strategy: A prescription unfilled. Toronto ON: Health
Council of Canada; January 2009.



                                             The End Until Next Time!




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