Medical Imaging and Treatment of Cancer

Tyler Bradshaw- Fall 2008 -Wilhelm Conrad Roentgen-1895 -Electrical discharges in a vacuum tube -Caused a phosphored screen to fluoresce -Formed an image of bone -First x-ray photograph of wife’s hand/ring   One year later British doctors were already using x-ray imaging. Prolonged exposure to x-rays caused tissue burns.  Wounds were abnormal- took time before appearing. •X-rays are electro-magnetic radiation. •Same as radio waves, sunlight, or microwaves. •The difference is in the wavelength/frequency Radio Waves: ~3 km 10000 Hz Microwave: ~ 1 cm 1010 Hz Visible Light: ~0.000005 mm 1015 Hz X-Rays: ~ 10-10 m 1018 Hz *Not to scale. Not even close. -The energy of a light-wave is carried by packets called photons -The energy of a photon depends on the light’s wavelength -Smaller wavelengths have larger energies Photon energies are usually given in units of electron volts (eV) 1 eV = 1.602x10-19 Joules Need 56,000,000,000, 000,000,000,000 eV to cook an egg. How do you create x-rays? 1. BREMSSTRAHLUNG 2. FLUORESCENCE •Charged particles emit photons when decelerating. •To form x-rays it must be very abrupt. •An electron arcs around the nucleus, emits an x-ray photon Heavy Atom High speed electron Energy released depends on the electron’s speed and proximity to the nucleus. Characteristic X-rays Electron-electron collision Both leave atom, leaving a vacancy in the inner orbital Vacancy filled by an outer electron Transition releases high energy photon High speed electron Heavy Atom Both methods occur in an x-ray machine BREMSSTRAHLUNG:  Photon energies vary: 10,000-90,000 eV.  Lower energy x-rays are more common. FLUORESCENCE:  Specific energies per atom.  Higher energy.  More useful. *Electron beam collides with a spinning tungsten disk *Electrons interact with the tungsten atoms *Both Bremsstrahlung and flourescence occur *Filter absorbs low energy x-rays 1) Imaging 2) Killing diseased/cancerous tissue X-rays are used because of their unique interaction with tissue and bone. There are four types of interactions… ST: 1 E LASTIC SCATTERING Absorbs x-ray, bounces up and down Re-emits x-ray No effect on the atom Bends the x-ray’s path (fuzziness) X-ray photon is absorbed Electron shoots away from the atom. Larger atoms are more likely to absorb an x-ray than smaller atoms. Bone (Ca) absorbs x-rays Tissue (C, H, O, N) transmit x-rays •Photoelectric effect: useful in imaging •When treating cancer, however, you must avoid harming surrounding tissue •To target the tumor, another type of interaction is used… rd: 3 Compton Scattering -1,000,000+ eV photons used -Photon collides with an electron -Both bounce off like billiard balls Compton scattering affects only a fraction of the tissue. To target the tumor it must be treated from many different angles. When a 1,000,000 eV photon collides with an atom, another type of interaction occurs… 4TH: ELECTRON-POSITRON PAIR PRODUCTION 2 E=mc Einstein postulated that energy can become mass, and mass can turn into energy. A small amount of mass can create a lot of energy. Electron-Positron Pair Production ee+ Electron Positron Antimatter: Symmetry in the universe. Almost all particles have an antimatter… Proton Neutron Electron Antiproton Antineutron Positron Matter-antimatter collisions turn mass into energy, and create an explosion. e+ e- “Annihilation” *These electron-positron pairs are formed in radiation treatment. *The newly formed positron quickly “annihilates” another electron. *Helps kill tumors.

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