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					4th Yearly Meeting of the Coordinators
     of the Centres of Excellence

            LIFE/MED
             Eva Syková
EU Centres of Excellence Bio-Med parallel Group
ARICY                     Agricultural Research Institute, Nicosia, Cyprus


BIER                      Jagiellonian University, Faculty of Biotechnology, Krakow, Poland


BIOREGION-SZEGED          Biological Research Centre, HAS, Szeged, Hungary


BLOODVESSELS              Institute of Cellular Biology and Pathology, Romania


CEBIOLA                   Vilnius University, Vilnius, Lithuania


CENEXFOOD                 Inst. of Animal Reproduction and Food Research, PAS, Olsztyn, Poland


DESMOL                    Centre of Molecular and Macromolecular Studies, PAS, Lodz, Poland


EMBEU                     Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland


EURO-NEURO-NETWORKS       Institute of Experimental Medicine, HAS, Budapest, Hungary


EXCELLENT PLANT BIOTECH   AgroBioInstitute, Sofia, Bulgaria


GENEMILL                  Estonian Biocentre, Tartu, Estonia


MEDIPRA                   Institute of Experimental Medicine, ASCR, Prague, Czech Republic


STRESSNUTS                Institute of Experimental Endocrinology, SAS, Bratislava, Slovakia
AgroBioInstitute, (ABI), Sofia, Bulgaria
CoE Acronym: EXCELLENT PLANT BIOTECH



                     Coordinators:
                     Prof. Atanas Atanassov
                     Dr. Ivan Atanassov




 “Promoting of sustainable and environment friendly
 agriculture through development, adoption and application
 of up to date biotechnology methods and know-how”
       CoE Excellent Plant Biotech: years of expending
             research and networking capacity

2000 Institute of Genetic Engineering (starting of CoE project)

2001 AgroBioInstitute (extanding of agrobiotech applications)

2002 new location of AgroBioInstitute (modern research facilities)

2003 AgroBioTech Park (joining of reserach, training and business
     activities)

2004 Biotechnology Information Center and Genome Center
     (public relations, genomics and metabolomics)
 Agricultural Research Institute,
            ARICY
• Coordinator
  I. Papadopoulos

• Engaged in applied and basic research in plant
  and animal production
• Provide high quality scientific results,
  environmentally and socially sustainable
         The genetic basis of Scrapie and the
         utilization of molecular techniques
                for its control in sheep

                                       1 2       3 4 5 6 7
•   The infection is associated
    with the PrP gene.
•   The allelomorph RR is
    associated with resistance to
    the disease. The onjective is to
                                       Polymorphic codon genotypes are:
    increase the frequency of
    resistant genotypes in the         171 Arg/Arg (lanes 1, 2, 3, 5, 6) and
                                       171 Arg/Gln (lanes 4, 7)
    population.
            Institute of Experimental Medicine
         Academy of Sciences of the Czech Republic
                         MEDIPRA
                   Coordinator: Professor Eva Syková

     Mission:
 Basic research in neuroscience,
  genetic ecotoxicology, cell biology and molecular pharmacology.
 Bridging the gap between basic research and clinical
  application.
European collaborations in MEDIPRA
          Most important scientific results

•   Mechanisms underlying development, aging,
    neurodegenerative diseases, brain and spinal cord injury

•   Stem cell research, in vivo MR tracking of implanted stem
    cells using superparamagnetic nanoparticles

•   Propagation and controlled differentiation of human
    embryonic stem cells

•   Molecular epidemiological studies: Biomarkers of exposure
    to mutagens and carcinogens and the embryotoxicity of
    genotoxic compounds
         Most important scientific results




Clinical study
Bone marrow stem cell implantation to treat spinal cord injury
  Estonian Biocentre, GENEMILL
• Main Mission:
   Basic and applied research in molecular medicine and
                       human genomics
      HUNGARIAN ACADEMY OF SCIENCES
INSTITUTE OF EXPERIMENTAL MEDICINE
            BUDAPEST, HUNGRAY




         Prof. E. Sylvester Vizi
         Prof. Zsolt Liposits

   NEUROSCIENCE RESEARCH
      CNS DRUG DEVELOPMENT
           HEALTHY SOCIETY
                  Bioregion-Szeged

Regional Initiative for Improvement of Quality of Life through    Research,
          Education, and Innovation in Molecular and Cell Biology

        Biological Research Center, Hungarian Academy of Sciences

                    Coordinator: Prof. DÉNES DUDITS




                                      Biological Research Center
                                  Hungarian Academy of Sciences
                                                 Szeged, Hungary
                                          CoE: BIOREGION-Szeged
             Training: schools, symposia

• Bioinformatics: PL, HU
• ITC lecture course and practicals (yearly)
• Biophysics:
   – Molecular structures and dynamics of energy converting membranes
     (23. June-2. July 2001)
     32 invited speakers from 11 European countries, the school was attended by 42 students
      from 11 European countries




                                                           Biological Research Center
                                                      Hungarian Academy of Sciences
                                                                     Szeged, Hungary
                                                               CoE: BIOREGION-Szeged
           Research deliverables
• 15 work packages
• More than 150 refereed publications
• Outstanding activities
   – Plant cell and molecular biology


                Nitrogen fixing root nodules




                                    Molecular structure of the NORK protein
   – Nanobiotechnology

                     Light-driven micromachinery
                     produced and driven by light

                                                    Biological Research Center
                                               Hungarian Academy of Sciences
                                                              Szeged, Hungary
                                                        CoE: BIOREGION-Szeged
         Cell Biology and Lasers:
        Towards New Technologies
                 CEBIOLA
Coordinators:    Prof. Benediktas Juodka
                 Prof. Algis Piskarskas

The mission of the center:
to promote research, advanced studies and training
in the field where cell biology meets light technologies
giving birth to diverse and ever-widening range of laser
applications in life sciences


                  Vilnius University, Lithuania
PHOTOSENSITIZED LASER TUMOUR
          THERAPY



               ALA-injection

                  Accumulation

                     Laser treatment

                          Necrosis


700 patients treated successfully in Lithuania
       LASERNET/LASERLAB-EUROPE
                                LENS: Firenze, Italy
                                ULF-FORTH: Iraklion, Greece
                                LIF-LOA: Palaiseau, France
                                LLC: Lund, Sweden
                                LCVU: Amsterdam, Netherlands
                                MBI: Berlin, Germany
                                LULI: Palaiseau, France
                                CLF: Chilton, England
                                GSI: Darmstadt, Germany
                                PALS: Prague, Czech Republic
                                CEA: Saclay, France
                                TU Vienna: Vienna, Austria
                                CEA: Bordeaux, France
                                LRC VU: Vilnius, Lithuania
                                CELIA: Bordeaux, France
                                CUSBO: Milano, Italy
http://www.lasernet-europe.de
Molecular Biotechnology - Integration of Education and
                       Research
                          BIER
    Jagiellonian University, Faculty of Biotechnology
                    Krakow, Poland




            Main mission of the Centre BIER:
             Combining research and teaching
      of molecular biotechnology at the European level
              Co-ordinator: Professor Aleksander Koj
           The most important scientific result
               (one selected from many):
Substantial progress in understanding of molecular
   mechanisms of stress tolerance in plant cells:
-- Elucidation of the effect of heavy metals on formation of
   photosynthetic apparatus;
-- Description of the cyclic electron flow around photosystem
   II in overexcitation conditions with a special emphasis on
   cytochrome b559.

                                   The model showing photoreduction
                                   sites of cyt c in thylakoids under low
                                   and medium light intensity (black „cyt
                                   c‟ symbol) and occurring additionally
                                   at high light intensities (white „cyt c‟
                                   symbol). The action sites of the used
                                   electron transport inhibitors are also
                                   shown.
    The most important outcome of BIER activity:


• International recognition of BIER as an expert
  teaching and research centre in molecular
  biotechnology

• Promotion of the Institute of Molecular Biology to
  the Faculty of Biotechnology located on a new
  Campus and offering full curriculum in
  biotechnology
  CENTRE OF EXCELLENCE FOR KNOWLEDGE TRANSFER,
    RESEARCH AND EDUCATION IN FOOD AND HEALTH
           for CENTRAL & EASTERN EUROPE


                              CENEXFOOD
Co-ordinator:
Prof. Halina Kozłowska




Main mission:
• training of young researchers in FOOD SCIENCE
• promoting trans-border mobility
• pan-European networking
                From science to local scocieties




     Exceptionally good relationship between scientists form Olsztyn
and Norwich led to start the process of twining of both cities (Sister Cities).
         DESMOL – Designed Molecules and Macromolecules
           Their Assemblies and Biological Functions
         Center of Molecular and Macromolecular Studies, Łódź, Poland


                       Coordinators:
                       Professor Marian Mikołajczyk
                       Professor Przemysław Kubisa

                       about 130 researchers and PhD
                       students involved


Mission:
- to combine the research activity and expertise of research teams
working in the area of heteroorganic chemistry, bioorganic
chemistry and macromolecular science
- to develop new interdisciplinary approaches to molecular and
macromolecular engineering, aimed at manufacturing of new
materials for applications in medicine and modern technology.
            DESMOL – Designed Molecules and Macromolecules
               Their Assemblies and Biological Functions
             Center of Molecular and Macromolecular Studies, Łódź, Poland



                                                            OH
                                                             OH                  OH                     OH
                                                                                                                OH
Most important scientific result:                     HO
                                                     HO           OH
                                                                   OH     HO             OH       HO

                                                                                              +

                                                     HO
                                                      HO          OH
                                                                   OH     HO             OH       HO               OH
New biodegradable materials based on polymers               OH
                                                             OH                  OH                     OH

                                                      STEREOCOMPLEX            (S)-PLA                      (R)-PLA
with special topologies (star-polymers and their
stereocomplexes) obtained from renewable                                Temperature / oC

sources (lactic acid)                                   0         50     100       150            200        250




Those materials may serve as biodegradable
comodity plastics or specialty materials for                                                  o
                                                                                         172 C
                                                                                                        o
application in medicine.                                                                            222 C
                                                   Melting temperature increases by 500C
                                                      (wider range of application)
            Centre of Excellence
            in Molecular Biotechnology
                     EMBEU

            Coordinator: Prof. Andrzej Rabczenko



Institute of Biochemistry and Biophysics
       Polish Academy of Sciences
           Warsaw, Poland
 Member of Ochota Campus Consortium
          EMBEU achievements
           selected from over 80 publications


• Proteomics study resulting in identification of new
  markers for Alzheimer‟s disease
• Novel inhibitors of HCV helicase
• Application of comparative genomics for
  identification of new protein targets to fight malaria
• New technology to use protease inhibitors in drug
  protection (patented)
• Genomics of clinically relevant plasmids
                EMBEU activity
• Exchange visits
• Organization of conferences, numerous workshops
  and courses
• Networking other CoEs (Cyprus, Bulgaria, Hungary, Poland)
• Inducing 4 new CoEs in our campus
• Promotion of the European cooperation resulting in
  15 FP5 and FP6 projects
• Establishment of FP5 Marie Curie Training Site –
  Education and Research in Molecular Biology
ROMANIAN ACADEMY
                   Institute of Cellular Biology and Pathology
                               “Nicolae Simionescu”
          Member of UNESCO Global Network for Molecular and Cell Biology

Title of the project                         Center of Excellence: “Blood Vessels”
Function and dysfunction of blood vessels: Coordinator: Dr. Maya Simionescu
transcytosis in normal/pathological states,
alterations in atherosclerosis and diabetes;
their therapeutic control
Research Program
Understanding the molecular and cellular mechanisms occurring in the
normal vessels, and the alterations of the arterial wall leading to the
cardiovascular diseases
Our Credo :
“Cellular and Molecular Biology for
the Benefit of Human Health”
Pharmacological Modulation of Endothelial Cell Function




                                                                 EC depend relaxation
                                                                = Structure
                                                                 Arterial pressure
                                                                 Atherosclerosis

        The effect of drugs on the cells of the vascular wall

                                                Anti-atherogenic drugs effects
                                      tested on the hyperlipemic and/or hyperglycemic hamster:

                                     statins (simvastatin, atorvastatin);
                                     calcium channel blockers (nifedipine, amlodipine);
                                     ACE inhibitors (enalapril, captopril);
                                     anti-thrombotic (enoxaparin, aspirin);
                                     vitamins (E and C);
                                     L-Arginine;
                                     "intelligent liposomes" for an efficient drug delivery.
    STRESSNUTS
    Institute of Experimental Endocrinology
    Slovak Academy of Sciences
    Bratislava, Slovakia



Coordinator:
Assoc. Prof. Daniela Ježová


Main „mission” of this Centre
   To provide experimental and clinical data
   leading to specific recommendations aimed
   at reducing the negative impact of
   environmental factors on human health
              Most important scientific result
                (one selected from many)


STRESSNUTS

Evidence has been obtained to support
further clinical research on the following
                                                Salivary cortisol
substances to modulate hormone release               (ng/ml)
and treat the negative impact of demanding                                           time: p<0.001
stressful situations, anxiety and depression:                                        treatment: p<0.05




                                                  changes from basal values
                                                                              1.5
                                                                                                                   placebo

                                                                                1
         mood stabilizers
         extract of Ginkgo biloba                                             0.5                                  lamotrigine
         pentoxifylline                                                         0
         antidepressants
                                                                              -0.5         stress
         selected amino acids                                                         0       15         30   45
                                                                                                                   min
    In all EU Centers of excellence the program
          has greatly contributed towards:
•   Mobility of scientists

•   Exchange of experience and know-how

•   Training at all levels

•   Through networking and twinning, excellent
    co-operation has been realized

•   Consortiums of scientists and institutions for joint
    projects for the 6th FP have been established
      Most important outcomes of the CoE
                 programme:
 Increased international recognition of the Institutes
 Participation of scientists in the 5th and 6th FP
 Success in obtaining national and international funding
 Expansion of the Institutes
 Strengthened collaborationin EU
 Start of clinical studies based on research conducted in the CoE
 Appointment of several outstanding young researchers
 Increased quality of scientific results and of publications
 New training activities, teaching courses
 Public lectures and press conferences
CoE Projects - bridge to the EU
• The program has undoubtedly fulfilled its
  purposes. It has contributed immensely
  towards the spirit of co-operation and exchange
  of scientific information between the scientific
  community

• This indisputable fact should be further
  promoted and supported (morally and
  financially) by engaging in similar programs
  for the benefit of the peoples of the new
  members of the United Europe

				
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