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					Shaping Arizona’s Future Bioscience Economy




                 Phoenix, Arizona



              Saundra E. Johnson
            Executive Vice President
                 Arizona HIMSS
                   May 8, 2009
                 Flinn Foundation

   Private foundation
    (Phoenix physician and
    spouse bequests)
   $215M endowment
    (12/07)
   9 member Board (50%
    M.D. or Ph.D.)
   $10M+ annual
    distribution (Arizona
    specific)
       Arizona’s Bioscience Roadmap

 Developed by Battelle in 2002
 Extensive research, interviews, focus
  groups, economic analysis
 10-year statewide plan
 Guided by committees of statewide
  leaders in science, business, policy
Arizona’s Bioscience Roadmap

         Develop Arizona as a global biomedical
         research and bioscience commercial
         center over the next 20 years.

            OBJECTIVES
                Leapfrog research opportunities
                Catalyze bioscience commercialization
            ACTIONS
                Make strategic investments in research
                 infrastructure
                Make strategic investments in
                 commercialization
                Recruit intellectual capital
                Provide guidance, support and
                 information on the biosciences
                           Defining the Biosciences

     Agricultural        Drugs &            Medical Devices        Hospitals   Research, Testing &
Feedstock & Chemicals Pharmaceuticals        & Equipment                       Medical Laboratories

   Agricultural          Medicinal &     Laboratory         Specialty        Biological
    processing            botanicals        apparatus &         hospitals         research
   Basic organic                           furniture
                          Pharma-                             University       Commercial
    chemicals              ceutical        Surgical,           medical           medical
   Ethyl alcohol          preparations   medical, dental,      research          research
    mfg.                                  ophthalmic            hospitals
                          Diagnostic     & analytical                           Testing
  Organic fiber           substances     instruments &        Clinical          laboratories
   mfg.                                   equipment             research
                          Biological                           institutions
                                                                                 Medical
   Fertilizers            products        Irradiation                           laboratories
                                            apparatus &                           & diagnostic
   Pesticides and                                                                imaging
    other agricultural                      electromedical
                                                                                  centers
    chemicals                               equipment



                         Product-Oriented                               Service-Oriented
       Battelle Research Convergence

 Core Competencies          Three Big O’s
    Bio-engineering            Genomics
    Cancer therapetutics       Proteomics
    Neurosciences              Bio-Informatics
    Bio-imaging

 Existing Strengths
    Electronics
    Optics
    Advanced
     manufacturing
           Why Arizona Invests in Bio

 Size and range of economic activity means economic
  diversity; significant new firms; and high paying,
  secure jobs across spectrum of employment areas

             veterinary   environmental biological
               testing                     testing
Services                   remediation
                                                     Research
                 agriculture    pharmaceuticals
                      organic      surgical
                     chemicals appliances
                             devices
                            medical
                             labs
                                       Manufacturing
             Why Arizona Invests in Bio

 It’s a focal point for technology convergence
  and continuing technology development


                      Electronics
   Imaging
                                     Information
                  Biosciences        processing

     Materials               Artificial
                           intelligence
       Our Statewide Approach



                           Flagstaff

Sun City/
 Surprise                  Scottsdale

Phoenix                    Chandler
  Tempe
  Oro Valley               Tucson
                  Bio Champions

 Bioscience Roadmap Steering Committee
    80+ members
    statewide
    senior leadership
    public: university vice presidents of research,
     research institute CEOs, legislators, mayors and
     city council members, governor's staff, school
     superintendents
    private: regional business leaders, bio company
     senior executives, hospital administrators,
     foundation CEOs
                            Arizona’s Bioscience Roadmap
                                                         Arizona’s Bioscience Roadmap Steering Committee
                                                                 Martin Shultz, Pinnacle West Capital Corp., Chair
                                                 Rt. Brig. Gen. Ron Shoopman, Southern Arizona Leadership Council, Vice Chair
 Communications & Public Affairs                      Workforce                            Education                    Investment & Capital Formation                          Research
          Paul Allvin, UA                         TBD, Banner Health            Catherine McKee, Morrison Institute         Lawrence Aldrich, C-Path                   Joseph Rogers, Ph.D., SHRI
    MaryAnn Guerra, Catapult Bio                 Steve Kiefer, MCCCD                 Jim Zaharis, Ed.D., GPL          Quinn Williams, Esq., Greenberg Traurig          Stuart Williams, Ph.D., BIO5
            Co-Chairs                              Co-Chairs (2008)                         Co-Chairs                             Co-Chairs (2007)                          Co-Chairs (2007)


                                                                                                                                                Asthma                                     Bio-Ag
     Federal & State Relations                                                                                                       Fernando Martinez, M.D, BIO5                 Charles Arntzen, Ph.D.,
      Jack Lunsford, Westmarc                                                                                AERO Capital                Richard Robbins, M.D.                            Biodesign
                                                                                                              Formation               Carl T. Hayden VA Med. Ctr                 Vicki Chandler, Ph.D., BIO5
      Jaime Molera, ABOR/UA
                                                                                                              Committee                     Co-Chairs (2007)                           Co-Chairs (2007)
             Co-Chairs



                                                                                                                                                                                         Bioimaging
                                                                       .


                      Northern Arizona Roadmap               Central Arizona                  Southern Arizona                              Bioengineering
                           John Haeger, NAU                                                      Roadmap                              Ranu Jung, Ph.D., Biodesign                 Robert Gillies, Ph.D., BIO5
                                                          Collaborations with cities,
                         Hon. Sara Presler, City of                                                                                   Stuart Williams, Ph.D., BIO5                  Jim Pipe, Ph.D., BNI
                                                           universities, government,        Hany Massarany, Ventana
                                 Flagstaff                                                      Medical Systems                            Co-Chairs (2006)                           Co-Chairs (2006)
                                                             business, economic
                                Co-Chairs                 development organizations            Leslie Tolbert, UA
                                                                                                  Co-Chairs



                                                                                                                                           Cancer Research                         Neurological Sciences
                                                                                                                                      Eugene Gerner, Ph.D., BIO5                  Frank Porreca, Ph.D., UA
                                                                                                                                     Larry Miller, Ph.D. Mayo Clinic             Joseph Rogers, Ph.D., SHRI
                                                                                                                                            Co-Chairs (2006)                          Co-Chairs (2006)


Legend:
    = Active                                                                                                                                                                         Grand Challenges
                                                                                                                                                                                        Collaboration
                                                                                                                                                                                 Laura Huenneke, Ph.D., NAU
    = On-Call                                                                                                                                                                    Rick Shangraw, P.h.D., ASU
                                                                                                              AZTransNet
                                                                                                                                                                                   Leslie Tolbert, Ph.D., UA
    = Spinoff
                               Metrics of Success
2002-2007
Metrics             Performance Comments
NIH Funding          24% (’02-’07)   Arizona performance outpacing top 10 States ( 11%) and U.S.
                                      ( 11%)
Bio Jobs             23% (’02-’07)   Arizona’s growth far exceeding country

Bio Firms            22% (’02-’07)   Medical devices; research, testing and medical labs are key
                                      segments
Bio Wages            34% (’02-’07)   Average salary: $52.5K
2002-2008
Metrics             Performance Comments
Bio Risk Capital     41% (’02-’08)   Reached 86% of goal in 2007 but only 65% of goal in 2008

Bio University IP
 Bio   Startups     50% (’02-’08)   42 bio startups 2002-08
 Bio   Licenses     15% (’02-’08)   176 licenses 2002-08
 Bio   Income       18% (’02-’08)   Total of $14.4 m. 2002-08; significant decline in 2008 over
                                      2006-07 levels
                  Arizona Bioscience Impact, Growth
     Annual total economic activity generated by the biosciences increased 46.6%
      from $14.5 billion to $21.2 billion
     Jobs from the total impact of the biosciences rose by almost 15,000 from 140,654
      to 155,631
     Annual state and local taxes generated grew 35% to $765.7 million

Total and % Change in Direct and Total Impacts of the Entire Bioscience Sector, 2002 - 2007 ($ in millions)

                                      Direct      Direct    % Change     Total       Total      % Change
              Item                   Impact      Impact      2002 -     Impact      impact     2002 - 2007
                                      2002        2007        2007       2002        2007
    Output                           $7,975.7   $12,539.3    57.2%     $14,451.2   $21,185.0     46.6%
    Employment                       72,855      87,417      20.0%     140,654     155,631       10.6%
    Employee
                                     $3,203.6   $5,327.5     66.3%     $5,176.6    $7,830.2      51.3%
    Compensation
    State and Local Tax
                                        –          –                    $566.9      $765.7       35.1%
    Revenues

   Source: Battelle TPP and IMPLAN
    Arizona Non-Hospital Bioscience Impact, Growth

  Annual total economic activity generated by the non-hospital biosciences sector
   increased 61.6% from $3.6 billion to $5.8 billion
  Jobs from the total impact of the non-hospital biosciences rose by 17.6% - 4,440
   jobs from 25,231 to 29,671
  Annual state and local taxes generated grew 34% to $177.8 million
Total and % Change in Direct and Total Impacts of the Non-Hospital Bioscience Sector, 2002 – 2007
($ in millions)

                                   Direct     Direct    % Change    Total      Total      % Change
           Item                   Impact     Impact      2002 -    Impact     impact     2002 - 2007
                                   2002       2007        2007      2002       2007
 Output                           $2,147.3   $3,641.2    69.6%     $3,615.3   $5,842.8     61.6%
 Employment                       10,895     13,543      24.3%     25,231     29,671       17.6%
 Employee
                                  $494.1     $777.8      57.4%     $949.5     $1,445.9     52.3%
 Compensation
 State and Local Tax
                                     –          –                  $132.5     $177.8       34.2%
 Revenues

Source: Battelle TPP and IMPLAN
                                Arizona Bioscience Wages

                                                                                      Avg. Annual             Avg. Annual             Increase,
              Major Industries & Bioscience Subsectors
                                                                                      Wages, 2006             Wages, 2007               06-07

          Management of Companies and Enterprises                                    $         66,311        $         74,293             12.0%
          Drugs & Pharmaceuticals                                                    $         56,274        $         62,540             11.1%
          Professional, Scientific, and Technical Services                           $         57,527        $         62,192              8.1%
          Research, Testing, & Medical Laboratories                                  $         57,031        $         60,564              6.2%
          Finance and Insurance                                                      $         58,895        $         59,487              1.0%
          Manufacturing                                                              $         57,627        $         58,402              1.3%
          Total Non-Hospital Biosciences                                             $         53,369        $         56,634              6.1%
          Information                                                                $         51,151        $         53,337              4.3%
          Total Biosciences                                                          $         48,674        $         52,481              7.8%
          Hospitals                                                                  $         47,763        $         51,685              8.2%
          Medical Devices & Equipment                                                $         48,958        $         51,651              5.5%
          Health Care and Social Assistance                                          $         42,962        $         44,912              4.5%
          Transportation and Warehousing                                             $         42,151        $         44,154              4.8%
          Construction                                                               $         40,907        $         42,526              4.0%
          Real Estate and Rental and Leasing                                         $         43,008        $         42,306             -1.6%
          Total Private Sector                                                       $         39,526        $         41,044              3.8%
          Agricultural Feedstock & Chemicals                                         $         39,875        $         40,449              1.4%
          Retail Trade                                                               $         28,393        $         28,492              0.3%


Source: Battelle analysis of BLS, QCEW data from the Minnesota IMPLAN Group. Wages are in current dollars (not adjusted for inflation).
                    Projected Bioscience Job Growth
   Among overall primary bioscience occupations (both clinical and non-clinical),
         latest projections for 2006-16 show a 10-year expected growth rate for bio-related
         jobs at twice that for all occupations (32% vs. 15%, respectively)
                                       Projected Annual Openings in Arizona Bioscience Occupations, 2006-16


                            Healthcare Support                                                                              2,842


                        Health Technologists &
                              Technicians
                                                                                                                  2,253


                             Registered Nurses                                                       1,741


                       Allied Health Therapists             343

                                                                                                Growth Openings

                                   Pharmacists             264                                  Replacement Openings



                         Medical & Clinical Lab
                                                           236
                              Technicians



                          Physician Assistants        83


                                                  -          500          1,000         1,500          2,000        2,500   3,000


Source: Battelle analysis of Occupational Employment Projections data from the Arizona LMI Office.
HEALTH CARE AND THE LIFE SCIENCES
     Key Trends in Health Care and the Life Sciences
     Two new disciplines have emerged to be recognized
         as powerful new approaches to research and health
         care:
            Systems biology, which seeks to integrate different levels
             of information about the parts of a biological system to
             understand how that system functions as a whole.
            Translational Science, which encompasses both the
             acquisition of new knowledge about health and disease
             prevention, preemption, and treatment and the
             methodical research necessary to develop or improve
             research tools.
     New health informatics / bioinformatics and data
         management approaches are emerging to deal with
         the acquisition, storage, retrieval and use of medical
         and research information.
Source: : PricewaterhouseCoopers
                                   Personalized Medicine

   Personalized Medicine is medicine that examines each individual's
   biological makeup and designs tailored strategies for maintaining
   and enhancing health and wellness and treating illness.

    Most traditional healthcare companies (payers,
        providers, pharma, biotech) are moving aggressively
        into this market through R&D, JVs, acquisitions, and
        new product development
             However, many of the winners in the market are likely to
              come from non-healthcare companies like Google,
              Microsoft, Cisco, Intel, P&G, Wal-Mart, and startups better
              able to operate in the new paradigm


Source: : PricewaterhouseCoopers
                                   Personalized Medicine
 We are at a tipping point in Personalized Medicine, driven rapid
 technological advances as well as other changes.

    Advances in personalized medicine are driven by many forces that include
             Collapsing technology costs in genomics and proteomics; within five years,
              genomes will be sequenced for $100 in an hour at any doctor’s office
             Increased process speed, storage, and bandwidth capacity enables IT
              therapeutic design; we can now apply IT tools to design drugs on a virtual
              basis
             Ubiquitous connectivity allows customized solutions in disease management
              and health and wellness; developments such as telehealth, homehealth, and
              web applications enable a new paradigm in personalized care outside the
              clinic
             Pay-for-performance, evidence / outcomes-based, consumer-directed
              healthcare will alter the standard of care from generic to specific; one size
              does not fit all
             Consumer empowerment, information and risk management creates
              educated and demanding consumers; the scope of solutions across the health
              and wellness continuum based is increasing base on consumer choice and
              perceived value
Source: : PricewaterhouseCoopers
      Personalized Medicine: New Partnership

 Stellar leadership team:
    Hartwell, Trent, Poste
   Led locally by TGen/ASU;
    also involves Arizona
    research universities,
    institutes, healthcare                           Lee Hartwell, Ph.D.
    providers, industry partners
   $45 million start-up
    package
   Proteomics next frontier in
    post-genomic era
   Arizona as international hub
    of proteomic research and      Jeffrey Trent, Ph.D.            George Poste, DVM, Ph.D.

    discovery
                      Biozona

 Quality of life: Local access to the newest medical
  discoveries and top healthcare practitioners. Local
  research helps local patients first.
 Economic rewards: High-paying, secure jobs that
  create a stronger, more diversified statewide
  economy. More jobs, better-quality jobs.
 The Right ingredients: Statewide collaboration, top
  talent, excellence in targeted research areas, long-
  term strategy, and rapid progress. Collaboration
  accelerates research.
                  Summary

 Commitment of public/private sector
  leadership has been sustained
 Strong private/public partnerships have
  mobilized to support the Roadmap
 The bioscience sector is a growing driver of
  our economy with clusters of bioscience firms
  focused on specialized niches
                Summary (Con’t)

 A challenge for Arizona’s policymakers will be
  to continue to invest in light of decreased
  federal funding and fiscal pressures
 But investing in the biosciences will result in
  significant benefits
   Good well-paying jobs that  will create economic
    opportunities and an improved quality of life
   Better healthcare for citizens
   Alternative fuels that can decrease U.S.
    dependence on oil and improve environment
    quality
More Information




    www.flinn.org
        Contact

Saundra E. Johnson
Executive Vice President
Flinn Foundation
1802 N. Central Avenue
Phoenix, AZ 85002
Voice: (602) 744-6831
E-mail: sjohnson@flinn.org
Web: www.flinn.org

				
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