Pathogen

From Wikipedia, the free encyclopedia Pathogen Pathogen A pathogen (from Greek πάθος path "suffering, passion", and γἰγνομαι (γεν-) gignomai (gen-) "I give birth to"), infectious agent, or (more commonly) germ, is a biological agent that causes disease or illness to its host.[1][2] There are several substrates and pathways whereby pathogens can invade a host; the principal pathways have different episodic time frames, but soil contamination has the longest or most persistent potential for harboring a pathogen. The body contains many natural defenses against some of the common pathogens (such as Pneumocystis) in the form of the human immune system and by some "helpful" bacteria present in the human body’s normal flora. However, if the immune system or "good" bacteria is damaged in any way (such as by chemotherapy, human immunodeficiency virus (HIV), or antibiotics being taken to kill other pathogens), pathogenic bacteria that were being held at bay can proliferate and cause harm to the host. Such cases are called opportunistic infection. Some pathogens (such as the bacterium Yersinia pestis, which may have caused the Black Plague, the Variola virus, and the Malaria protozoa) have been responsible for massive numbers of casualties and have had numerous effects on afflicted groups. Of particular note in modern times is HIV, which is known to have infected several million humans globally, along with the Influenza virus. Today, while many medical advances have been made to safeguard against infection by pathogens, through the use of vaccination, antibiotics, and fungicide, pathogens continue to threaten human life. Social advances such as food safety, hygiene, and water treatment have reduced the threat from some pathogens. Not all pathogens are negative. In entomology, pathogens are one of the "Three P’s" (predators, pathogens, and parasitoids) that serve as natural or introduced biological controls to suppress arthropod pest populations. Hepadnaviridae, Flaviviridae, Retroviridae, Orthomyxoviridae, Paramyxoviridae, Papovaviridae, Rhabdoviridae, Togaviridae. Some notable pathogenic viruses cause: smallpox, influenza, mumps, measles, chickenpox and rubella. Ebola is another pathogenic virus. Viruses typically range from between 20-300 nanometers in length. Bacterial Although the vast majority of bacteria are harmless or beneficial, a few pathogenic bacteria can cause infectious diseases. The most common bacterial disease is tuberculosis, caused by the bacterium Mycobacterium tuberculosis, which effect about 2 million people mostly in sub-Saharan Africa. Pathogenic bacteria contribute to other globally important diseases, such as pneumonia, which can be caused by bacteria such as Streptococcus and Pseudomonas, and foodborne illnesses, which can be caused by bacteria such as Shigella, Campylobacter and Salmonella. Pathogenic bacteria also cause infections such as tetanus, typhoid fever, diphtheria, syphilis and leprosy. Bacteria can often be killed by antibiotics. They typically range from between 1-5 micrometers in length. Fungal Fungal microbes can cause diseases in humans, animals and crop plants. Fungi most often infect immuno-compromised patients or vulnerable people with a weakend immune system. Most antibiotics cannot be used to treat fungal infections due to the fact that fungi and their hosts both have eukaryotic cells. Most clinical fungicides belong to the azole group. The typical fungal spore size is 1-40 micrometer in length. Potency A new theory regarding pathogens states that the longer a pathogen can survive outside of the body, the more dangerous it can be to a potential host. For example, the smallpox virus (variola virus) can survive outside the human body for approximately 885 days. It is also one of the most deadly pathogenic viruses, as it kills 1 in 10 of the people it infects. The tuberculosis bacterium kills 1 in 5 of the people it infects, but only survives 244 days outside of its host. The Ebola virus has devastating results, 9 out of 10 infected people will die from it. In countries that have higher sanitation standards, pathogens cannot survive for as long outside of the human. This is seen as encouragement to mutations to the pathogen which would make it less deadly, as such Types Below is a list of different types of notable pathogens as categorized by their structural characteristics, and some of their known and predicted effects on infected host. Viral Further information: Table of clinically important viruses Pathogenic viruses are mainly those of the families of: Adenoviridae, Picornaviridae, Herpesviridae, 1 From Wikipedia, the free encyclopedia mutations would allow the pathogen to survive in the host for longer periods of time. Pathogen • Mycobacterium leprae — the bacterium that causes leprosy (Hansen’s disease) • Yersinia pestis — pneumonic, septicemic, and the notorious bubonic plagues (aka "Black Death") • Rickettsia prowazekii — the etiologic agent of typhus fever • Bartonella spp. • Spanish influenza virus Transmission One of the primary pathways by which food or water become contaminated is from the release of untreated sewage into a drinking water supply or onto cropland, with the result that people who eat or drink contaminated sources become infected. In developing countries most sewage is discharged into the environment or on cropland as of 12 August 1985; even in developed countries there are periodic system failures resulting in a sanitary sewer overflow. See also • Emerging Pathogens Institute References [1] [2] http://www.medterms.com/script/main/art. http://www.metapathogen.com Examples of pathogens Major human pathogens • Mycobacterium tuberculosis — the causative agent of most cases of tuberculosis Retrieved from "http://en.wikipedia.org/wiki/Pathogen" Categories: Microbiology This page was last modified on 17 May 2009, at 21:16 (UTC). All text is available under the terms of the GNU Free Documentation License. (See Copyrights for details.) Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a U.S. registered 501(c)(3) tax-deductible nonprofit charity. Privacy policy About Wikipedia Disclaimers 2