Tumor targeting contrast agents _51436 by heku


									?Cancer, liver cancer, targeting, angiography, malignant tumors

?Tumor targeting contrast agents


Cancer remains a serious threat to human life and health of one of
the most dangerous diseases. In particular, the lack of typical
symptoms of cancer early, when found, the majority are advanced, the
prognosis is very poor. Early diagnosis and early treatment is
improving its survival, the key to reducing the recurrence rate.

In recent years, emerging ultrasound technology for cancer and other
diseases of early detection and diagnosis provides important
technical means, in practice. The normal contrast agent specificity
is not strong. These contrast agent itself is no affinity for the
lesions. Only lesions are nonspecific, unable to determine the
lesions, severely limits the acoustic imaging of further clinical
application. As a contrast agent of continuous development and
preparation technology matures. Guangzhou medical college affiliated
hospital Yang Xue-thoracic surgery

Currently, people have begun to focus on the study of tumor specific
targeted ultrasound contrast agent and targeted ultrasound imaging.
It is the specific antibodies or ligand is connected to a contrast
agent surface build into targeted ultrasound contrast agent that
relies on an antibody or Antigen ligands a receptor specific binding
between the contrast agent initiative into a specific target or
target organ, achieve tumor-specific targeting developer. Such as
tumor diagnosis early qualitative positioning provides a new way and
new tools. In recent years tumor targeting acoustic imaging research
is very active, but foreign scholars focused on targeting tumor
angiogenesis acoustic imaging studies. Panoramic view of the targeted
contrast study exploring the history of targeted ultrasound imaging
is the most classified of targeting acoustic imaging expert research
group led by Klibanov. They have a successful synthesis of a series
of targeted micro-bubble and related micro-bubble in vitro study
found. And demonstrated targeted ultrasound imaging of potential
prospects. Successive Ellegala, based on the alpha (V) beta3 is tumor
endothelial on expression of specific receptors, alpha-(V) to connect
to the beta3 antibody liposomes micro-bubble to the surface. Use of
Antigen-antibody specificity of the nature of the combination enables
tumor targeted ultrasound imaging diagnostic purposes. They
successfully copied rat brain glioma, on the basis of the model into
targeted ultrasound in vivo microscopy discovery targeting micro-
bubble more gathered in tumor microvessels and non-targeted micro-
bubble is not this phenomenon observed targeted micro-bubble signals
more concentrated in chelate in most parts of the tumor and its
periphery. signal and tumor intravascular relevant experiencing a
significant amount of blood. I.eong Poi, etc. using Matrigel basement
membrane analogues angiogenesis models have been observed on alpha (V)
beta3 Integrin antibody modification of micro-bubble contrast agents
for effective adhesion in tumor angiogenesis endothelial. rather than
targeting the control group did not see micro-bubble contrast agents
for Imaging. The results of these studies have consistently confirmed
that coupling (V) alpha-beta3 antibodies of micro-bubble contrast
agents targeting the validity of the vascular imaging and feasibility.

Domestic addition tumor targeting the application of ultrasonic
imaging research, in recent years undertaken directly against tumor
cells targeted ultrasound imaging studies such as high as the
leadership of the research team in targeting hepatocellular carcinoma
in ultrasound imaging have done a lot of fruitful work. They are
cultured in primary liver cancer cells observed against
hepatocellular monoclonal antibody modification of membrane micro-
bubble has better ability to find target in vitro, in vivo tumor
model found using specificity against hepatocellular monoclonal
antibody modification of microbubble brake can to a certain degree on
enhanced qu primary liver cell carcinoma of the specificity of
Imaging. Targeting micro-bubble contrast agents for developing new
areas of application, at the same time as the primary liver cell
carcinoma of the early qualitative diagnosis provides a new way of

?Cancer, liver cancer, targeting, angiography, malignant tumors

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