Clinical-Epidemiological Investigation of Kumri in goat-Banke-District-Nepal-: 2063 Dr.Kedar Karki Objective of Investigation:     To ascertain the cause of syndrome. Detection of microfilaria from clinical case. To evaluate the change in hematological parameter of clinical case. To evaluate the effectiveness of Diethylcarbamazin in treatment of Kumri Methodology     Clinical-epidemiological observation. Treatment of affected flock. Morning blood collection in EDTA. Estimation of TLC,DLC,TEC ,Hb,PCV. Background     Goats above twelve months of age mostly affected. Typical clinical signs in affected goats were paralysis of one or both fore/ hind limbs, paralysis of Lumber region In -coordination and swaying back gait. Clinical picture OUTBREAK INVESTIGATION. V.D.C. Total goat Affected Dead KUSUM KACHNAPUR 562 1720 1552 1825 175 480 390 495 20 27 35 45 MAHADEVPURI KOHALPUR KAMDI 1775 498 35 Results of Hematological Examination Differential cell count Basophil Eosinophil Monocytes Lymphocytes Nutrophil R.B.C Normal value Sample value 0-3% 1-8 % 0.46 % 8.78 % W.B.C. Hemoglobin P.C.V. 1-5 % 40-70 % 10-50% 8-18mil/m 13-15m/m 8.8-13.8% 25-40% o.93 % 57-63 % 32.20 % 3.3-4.6m/m 6.2-8.5m/m 6.6-9.3 % 20-28 % Blood examination for parasite    Total Samples.1o Sample Positive for Microfilaria:6 Negative:4 Setaria spp.Refference Pic •In peritoneal cavity of CATTLE Setaria spp. Reference photomicrograph Microfilaria in Peripheral blood circulation. Reference photomicrograph MICROFILARIA IN BLOOD( GOAT).  The sheath is most easily seen as it extends beyond the anterior and posterior ends of microfilaria. Reference photomicrograph Microfilaria in Blood posterior end Microfilaria in Blood Anterior end Microfilaria in Blood mid Microfilaria in Blood anterior end Microfilaria in faeces Microfilaria in faeces Worldwide Epidemiology of Disease         INDIA NEPAL. ISRAIL. SAUDI ARAB. SHRILANKA JAPAN. South Korea. Thailand. Epidemiological Discription of disease MORBIDITY MORTALITY POST. DEFORMATY DURATION OF DISEASE AGE/ANIMAL CONDITION/ANIMAL 30% 10-15% 2.5-5% 7-15 Day 1Yr/Above Healthy Result and Discussion         Presence of microfilaria in 60% of blood sample. Positive response to treatment. (Mukhopadhay.S et.al 1996) Hematological finding: ANAEMIA. EOSINOPHILIA. NEUTROPHILIA. LYMPHOCYTOSIS. DECEASE IN TOTAL R.B.C. COUNT. DECEASE IN TOTAL W.B.C. COUNT. (David E. Anderson 2002) Recommendation     Seasonal Pattern of occurrence of posterior paralytic symptom is caused by cerebrospinal nematode Seteria spp, Prevalence of disease occur when mosquito vectors are active. Can be treated and prevented by using Diethylcarbamazin. (P. Ghalsasi et.al 7th international Conference on goats, France may 2000 Use of ivermectine is contraindicated during microfilaraemia stage ( Michel Boussinesq et.al Filarial journal 2003) Acknowledgement       Dr.Rebtiman Shrestha Chief CVL. Dr.Ganesh Raj Pant SVO Dr.Poornima Shrestha SVO Dr .Vinay Kumar Karna.VO Mr.Prakash Devkota Vet.Tech. CVL All staff and Goat farmers group of Banke for their role in field and laboratory investigation of this disease