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PSA concepts related to the diagnosis of prostate cancer _32730

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					?Prostate cancer, prostate cancer, checks, and specificity




?PSA concepts related to the
diagnosis of prostate cancer

?

PSA (prostate-specific antigen) is a prostate cancer is the most
specific to the site of tumor markers for prostate, is composed of
the epithelial cells of the secretion of serine proteases. Normally,
rich PSA prostate acinar contents and lymphatic system between the
inner cortex and basal cell layer and basement membrane consisting of
a barrier. When cancer or other diseases undermining the shield, pit
contents to leak into the lymphatic system and into the blood
circulation, resulting in the peripheral blood PSA levels to rise.
Beijing Xiyuan hospital Urology Gao Zhan

(1) the timing of the check PSA: the diagnosis and treatment of
urologic diseases Guide recommends that men over the age of 50 should
accept a PSA checks for a family history of prostate cancer in men,
it should start from 45-year-old once a year.

(2) determination of PSA results: comparison of domestic and foreign
has the view that serological total PSA > 4.0ng/ml for the exception,
for the initial review recommended that the abnormal PSA. When t-PSA
is between 4-10ng/ml, the possibility of occurrence of prostate
cancer is greater than 25%. When the serum t-PSA is between 4-10ng/ml,
f-PSA levels and incidence of prostate cancer as well. Domestic
recommend f-PSA/t-PSA > 0.16 for normal value.

Prostate Biopsy:

Prostate Biopsy should be in the pelvic cavity after MRI-guided B.

Prostate Biopsy evidence:

1 digital rectal examination found nodules, PSA values.
2 b-prostate hypoechoic nodules or MRI suspicious signal, no PSA
values.

3 > 10ng/ml PSA. any f/t PSA.

4 PSA4-10ng/f/ml, tPSA exception

If PSA4-10ng/f/ml, tPSA, image properly, you should close follow-up.



Keywords:
?Prostate cancer, prostate cancer, checks, and specificity

				
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posted:11/5/2010
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