Latanoprost induced prostate drops in 1 case of bronchial asthma _in the adverse drug reactions magazine published _36205 by heku

VIEWS: 54 PAGES: 3

									?Drugs, breath, breathing difficulties, salmeterol and fluticasone
propionate inhalation powder, check




?Latanoprost induced prostate
drops in 1 case of bronchial
asthma (in the adverse drug
reactions magazine published

?

    Ma Xue Tao sea Han Cui (Beijing people's armed police Chief of
                    Ophthalmology, Beijing 100039)

Summary 1 patients 65 years of age, as a result of the female
patients with glaucoma Zlatan prostaglandin eye drops, 1st medication
2 h after breathing difficulties, cyanosis, check heart rate 120/min,
double lung full of wheezing tone. Immediately to the patients of
inhaled salmeterol and fluticasone propionate inhalation powder, 10
min after symptoms eased. Armed police Chief of Ophthalmology Ma Xue

Keywords Zlatan prostaglandin drops; bronchial asthma

A case of Asthma following latanoprost eyedrops

Ma Xuelian, Tao Hai (Department of Ophthalmology,Armed Police?
General Hospital,Beijing 100039)

ABSTRACT? A 65-year-old woman with glaucoma was applied of latanoprost
eyedrops.After 2 hours,she developed dyspnoea , cyanopathy, a heart rate of 120
beats/min and wheezing in the lungs all over.The patient was given
salmetrol/flutieasonea immediately,and asthma-like symptom disappeared after
ten minutes later.

KEY WORDS? laranoprost? eye drops;? asthma
Female patients, aged 65. As a result of both eyes, sour, to 2d
appeared dull or washed out fuzzy Oct. 20th, 2007. February 8, 2005
by similar symptoms in patients with local hospitals with high
intraocular pressure measurement (right eye: 25.7mmHg, left eye:
23.7mmHg), a diagnosis of glaucoma. March 14, "do" in the left eye
trabeculectomy, right eye laser angioplasty of the corner. " Post-
operative intraocular pressure in the right eye has control of the
poor, to have a history of 50 years of bronchial asthma, nearly half
of the year no attack. There is a history of allergy to sulfa drugs,
no other adverse drug reactions. Physical examination: no bilateral
internal thoracic deformity, symmetrical movement, language flutter
symmetric no increase or decrease. Double lung percussion is clarity,
lung and liver territories located in the right clavicle in the fifth
intercostal space in the Middle, both lungs breath sounds clearly,
not smell and dry wet Rale and pleural rubs. Precordial no
exceptional uplift, apical is located in the fifth intercostal space
in the middle left clavicle 0.5cm, palpable and fine tremor and lifts
the beating of the heart, not dull, heart rate 72 times per minute,
law, and the valve auscultation zone is not heard and pathological
noise and pericardial rubs. Eye examinations: eyes eyesight
correction for 0.7, does not improve. IOP: right eye: 24 mmHg (1mmHg
= 0.133KPa), left eye: 12 mmHg. Eyes clear, anterior chamber depth of
cornea, Iris and the pupil color normal, round, Center, diameter of 3
mm, both direct and indirect light reflex normal, mild cloudy lens,
vitreous body transparent. Left eye at 1 o'clock position with a
triangular cut holes, Iris week 12: 00-visible flat filtering bleb.
Fundus examination: eyes and disc the size of the border clearance,
as usual, right eye C/D = 0.4, left eye: C/D = 0.5, slightly lighter
color. Diagnosis: right angle glaucoma eye laser angioplasty
intraocular pressure out of control, left eye after trabeculectomy;
eyes senile cataract (early). Give patients 0.005% Zlatan
prostaglandin drops (shilida drops) point in the right eye, 1/d. Oct.
20th, 2007 the first point in the right eye shilida drops after 2h
0.1ml, dyspnea, cyanosis, sweat, check R:32 time/min, HR 120
times/min, BP160/100mmHg (1mmHg = 0.133kPa), T37.1 ° C, double lung
full of wheezing tone. Immediately to the patients of inhaled
salmeterol and fluticasone propionate inhalation powder (salmeterol
powder for inhalation), each containing salmeterol inhalation 50ug
and fluticasone propionate 10min 100ug, symptoms eased. Deactivate
shilida drops, use 1% no forest left amine drops (trade name:
brinzolamide), shortness of breath, do not induce asthma.

Discuss Zlatan prostaglandin drops (0.005% Zlatan prostaglandin drops)
to prostate F 2 P G α right spin isomer, active ingredient
Lantanoprost is a kind of propyl ester, ester of prostaglandin F 2 P
G α-Terminal hydroxyl functional group replaced by propyl, an
increase of lipophilic and penetrating keratoplasty, its good
hypotensive effect, ocular tolerance and clinical compliance for
numerous clinical studies confirmed. Their reactions are IRIS color
burn [1], Eyelash growth, conjunctival hyperemia [2], there are reported
using the flatin prostaglandin after cystoid macular edema [3],
allergic dermatitis caused by the drug also reported [4], but so far
there has been reports of bronchial asthma induced by rare. A history
of asthma cases have 50 years, right eye angle laser angioplasty,
right eye IOP has no control, Zlatan prostaglandin drops point right
eye after 2h after bronchial asthma, consider Zlatan prostaglandin
drops induced asthma attack. Latanoprost eyedrops is a prostate drugs,
prostaglandin is an inflammatory Mesons, can cause bronchial airway
secretion contraction, hyperthyroidism and airway hyperresponsiveness
and thus induced asthma attack. Hope that ophthalmologists more
attention in the future, must ask to patients, patients with a
history and advised of the possibility of induced asthma prevention
and knowledge of possible, close observation after administration,
there is a change in a timely manner.

Reference documents

[1] Dutkieuicz R, Albert DM, Levin LA .Effects of latanoprost on
tyrosinase activity and mitotic index of cultured melanoma
lines[J].Exp Eye Res , 2000, 70(5):563~569.

[2] edge de hwan. prostate drugs in glaucoma [J]. Harbin
pharmaceutical, 2005, 25 (1): 52-54.

[3] Zhang, Yan Tang, Sun w m, et al. prostaglandin analogs in
glaucoma treatment and progress. China's practical Ophthalmology 2002,
20 (5): 326-327.

[4] Lai-C-H;Lai-I-C;Chi-C-C,.Allergic contact dermatitis caused by
latanoprost ophthalmic solution.European. Journal of Ophthalmology,
2006, 16(4):627-629.



Keywords:
?Drugs, breath, breathing difficulties, salmeterol and fluticasone
propionate inhalation powder, check

								
To top