BioPause-AM Info sheet back pg

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					BioPause-AM™ ~ used to balance symptoms associated with endocrine disturbances.
Cimicifuga racemosa (root)                           Black Cohosh
Rhodiola rosea extract (root)                        Golden Root
Leonorus cardiaca (aerial part)                      Mother Wort
Vitex Agnus-castus (berries)                         Chasteberry

Recommendation: 2 caps taken each morning
Cimicifuga racemosa root (Black Cohosh) is very effective in decreasing hot flashes and night sweats. Black
Cohosh is approved by the German Commission for the treatment of menopausal symptoms. A study conducted in
1982 (by Stolze) consisting of over 600 menopausal women showed clear improvement in over 80% of the
participants within 8 weeks. While having shown estrogenic effects in some studies, Cimicifuga doesn’t elevate
estrogen levels. Rather is seems to bind estrogen receptors to mimic the hormone effects of estriol. (L.E. 763-6).
Black Cohosh had traditionally been used a nervine. However, its current oral uses seem to be specific for
depression or other disturbances relating to the menstrual cycle or menopause in women. Cimicifuga has shown
to offer good therapeutic efficacy and tolerability, and has an excellent record of safety.

Rhodiola (Golden Root) is an adaptogen that helps support normal adrenal function. Many women, because of their
hot flashes and sweats, have fatigue, and the Rhodiola doesn’t seem to heat up the body like some of the other
adaptogens. Traditionally, Rhodiola was used for its beneficial effects of physical endurance, and to treat fatigue,
depression, anemia, impotence and nervous system disorders, among others. Research on extracts of Rhodiola
found them to be a powerful adaptogen that protected animals and humans from mental and physical stress. After
more than a decade of research by Kurkin et al, evidence was presented showing the chemical composition of
Rhodiola rosea roots is different from other species of the plant, and that it contains rosavin, rosin and rosarin –
three cinnamyl alcohol vicianosides referred to as rosavins, that are specific to this species.
In Sweden, the Textbook of Phytomedicine for Pharmacists recognizes Rhodiola as an Herbal Medicinal Product
and describes it as an anti-fatigue agent. It is also registered in Denmark as a medical product and is used to
increase mental work capacity during stress, and as a psycho stimulant. Rhodiola’s benefits may be due to the dual
action of emotional calming and cognitive stimulation. In an open study of 128 patients (aged 17-55) Rhodiola
rosea alleviated fatigue, distractibility, and other vegetative symptoms in 64 percent of cases. The improvements
were documented using psychological testing and work productivity. Many forms of stress can decrease serotonin
in the hypothalamus. Rhodiola’s ability to increase the nonspecific resistance may be related to its capacity to
increase serotonin in the hypothalamus and midbrain. It reduces the activation of components of the stress
response system. It modestly increases serum beta-endorphin that protects animals against stress-induced excess
endorphin elevation, and moderates the release of opioid peptides that occur as part of the pituitary adrenal axis
response to stress.
In 2001, Dr Patricia Eagon found that Rhodiola rosea showed strong estrogen binding properties.
Overall, Rhodiola rosea has very few side effects, and most users find it improves their mood, energy level and
mental clarity. It is best taken early in the day.

Leonorus cardiace, (Mother Wort) has long been used for palpitations associated with hot flashes. Mother Wort,
like Black Cohosh, was historically used as a nervine, but is principally used for symptoms associated with
menopause or women’s menstrual cycle.
Mother Wort contains iridoide monoterpenes, flavonoids (including rutin, quercitrin,, iso-quercitrin, and
hyperoside), caffeic acid derivatives, tannis and betaine (as N-dimethyl-L-proline).
Mother Wort provides calming via its mild sedative effects which are beneficial for nervous palpitations often
experienced by women with menstrual or menopausal symptoms.
There are no health hazards or side effects known for normal usage of L. cardiaca.

Vitex Agnus-castus (Chasteberry) is calming and helps support menstrual regularity. It is appropriate for
women still menstruating but having hot flashes. It calms them down. Chasteberry has been used to treat
menstrual symptoms since ancient Greek times. Vitex also normalizes pituitary functions esp. progesterone
function. V. Agnus-castes contains iridoid glycosides, flavonoids and some volatile oils. According to the German
Monograph, Chasteberry inhibits the secretion of prolactin (in-vitro).
Indications for use of Chasteberry are irregularities of the menstrual cycle and premenstrual complaints.

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