Hawai i Society of addiction Medicine Volume Issue StAte
Document Sample


Hawai‘i Society of addiction Medicine
Volume 2 Issue 1
StAte of the Art:
Snips and Tales of Addiction Medicine
Christopher Linden, MD
HSAM MISSION:
The Hawaii Society of
T he nations capital,
Washington DC, was
the place for the 6th Annual
Addiction Medicine (HSAM) is
an association of physicians
dedicated to improving the
treatment of alcoholism
American Society of and other addictions,
Addiction Medicine’s State of educating physicians and
medical students, promoting
the Art scientific conference.
research and prevention,
This is arguable the single and enlightening and
best conference in the world informing the medical
community and the public
for an update in the field of about these issues. The
addiction medicine. Society serves its members
The first day was anything by providing opportunities
for education and sharing
but routine. Meeting in Dr. Paul Greengard, (left) 2000 Nobel Laureate in Medicine, shares a break of experiences, and by
the venerable rooms of with HSAM members Dr. Chris Linden, Dr. Gabrielle Batzer and Dr. Kevin promoting the development
Kunz. Dr. Greengard lectured on the neurobiology of addiction at the of a body of professional
the Capital building we
ASAM State of the Art Conference on October 26, 2005 in Washington D.C. knowledge and literature
discussed a number of to enhance the quality and
bills coming up for vote, Abercrombie and Case to bills is questionable but the increase the availability of
appropriate health care for
including parity for the argue the importance of experience was priceless. people affected by addictions.
treatment of addictive understanding the biologic Dr. Nora Volkow
disease. In small groups nature of this brain disease The keynote speaker Officers
we trooped off to the and the importance of the for the conference, Nora President
offices of Senator Akaka, current bills on the floor. Just Volkow, MD, Director of the George Carlson, M.D.
Inouye, and Representatives how much we did for the ART ~ continued on pg. 4 Secretary
Daryl Monceaux, M.D.
Treasurer
2006 ASAM CertifiCAtion exAM David Friar, M.D.
Immediate Past President
Exam Date: December 9, 2006 Kevin Kunz, M.D.
cOmmittee chairs
P hysicians who
wish to apply for
ASAM certification or
in New York, Los Angeles
and Atlanta. Physicians
who pass the examination
the Alternate Pathway,
the Review Course Study
Guide, and how to prepare
CME
Dr. Christopher Linden
recertification exam must become ASAM certified in for the Exam. Public Policy/Legislative
Dr. Gerald McKenna
complete the application Addiction Medicine. Since If you need more
Membership
and mail it to ASAM. the examinations were first information you may Dr. Gabrielle Batzer
To request an offered in 1986, over 4,000 contact the Credentialing
application, please call physicians have passed Program Director contact information
Christopher Weirs at 301- the examination, including Christopher M. Weirs, MPA Administrative Assistant
656-3920 ext. 106. You many of the nation’s Ph: 301-656-3920 ext. 106 Liza Lee
can also download an top addiction treatment Fax: 301-656-3815 808.536.7702 ext. 105
application from the ASAM professionals. email: cweir@asam.org
web site at www.asam.org. You may visit the Address: www.hsam.info
The next Certification and ASAM web site for more ASAM - Credentialing Dept. Newsletter inquires and/or
Recertification Examination certification information at 4601 N. Park Ave., corrections may be directed to
for physicians in addiction www.asam.org. There you Upper Arcade #101 Jacque Martin
medicine will be offered will find information about: Chevy Chase, MD 20815 PRessence Hawaii
Saturday, December 9, 2006 Suggested Reading Lists, pr_in_paradise@ yahoo.com
808.685.2871 or 808.429.3291
Hawai‘i Society of addiction Medicine
Page 2
fAMily PhySiCiAnS ConferenCe to feAture
AddiCtion MediCine CMe
HSAM is providing several clinical areas. be presented Friday from Complete program and
2 hours of addiction The grouping of three 3:30 –5:00 p.m.: registration information
medicine education at the addiction lectures focuses The History of Opiates in is available at the HAFP
upcoming annual meeting attention on a topic now Medicine and Society website (www.hafp.com),
of the Hawaii Academy all too familiar to Hawaii State of the Art Addiction which has a link at the
of Family Physicians. The physicians. Particularly, Therapies HSAM website.
conference will take place family physicians Outer island and
February 17-19, 2006 at encounter persons The third lecture will be mainland attendees can
the Renaissance Ilikai with alcohol and drug presented Sunday the 19th stick around Monday,
Resort in Waikiki. addictions daily, and are at 9:00 a.m. President’s Day – February
Hawaii Update 2006: often the first professionals The Epidemic of 20, for the Great Aloha
Keeping Families Healthy approached for help, either Prescription Drug Abuse Run, and join 25,000 other
and Fit, is sponsored by by the substance user, or – Strategies for Family endorphin seekers on the
the HAFP Foundation, and their family. Physicians 8 mile walk/run (www.
offers 18 CME credits in The first two lectures will greataloharun.com).
GreAt Web SiteS
Online
neuroscience experts. the Brain Loses Control. organization is JTO – Join
Neuroscience
Many of these are relevant A seminal lecture given Together Online – one of
Lectures
to addiction medicine. by Nobel Laureates Dr. the largest sites reviewing
www.utdallas.edu/
For instance, there is an Greengard, mentioned and cataloging substance
~kilgard/lectures.htm
excellent 45-minute review elsewhere in this newsletter, abuse information. The
This site has streamed presentation by Nora Volkow, and Dr. Eric Kandel reviews site post 100 new pages
video presentations from M.D.: Drug Addiction –Why synaptic transmission in each week, and currently
the brain, and includes the features over 40,000
Calendar of Events perturbations caused by daily news, fundraising
drugs of abuse as well as articles, action alerts and
Hawaii Academy of Family Practice societal implications. in-depth feature stories.
February 2006 Annual Meeting
Honolulu, Hawaii
The documents are fully
HSAM being given 21/4 hours of presentation time. Join Together searchable, and date back
Our HSAM CME Chair Dr. Chris Linden coordinated these presentations. www.jointogether.org to 10 years. There are
These will be “state of the art” presentations, with practical, applicable
information for Hawaii’s family physicians. also links to additional
Join Together was
Friday, February 17th resources. 100,000 people
founded in 1991 to support
3:15 - 4:00 receive the free weekly
The History of Opiates in Medicine and Society community-based efforts
edition, and a daily edition
Christopher Linden, M.D. to reduce, prevent, and
is also available. If there is
4:00- 4:45 treat substance abuse. It
State of the Art Addiction Therapies something about drugs
is funded by The Robert
Dr. William Haning (tentative) or addiction in the news,
Wood Johnson Foundation
Sunday, February 19th you’ll see it here. A link
and the Boston University
9:45 - 10:30 from the HSAM web site is
The Epidemic of Prescription Opiate Abuse: Strategies for Family Physicians School of Public Health.
Kevin Kunz, M.D., FASAM
planned for 2006.
The backbone of the
Hawai‘i Society of addiction Medicine
Page
AnnuAl AdvoCAte
for reCovery
AWArd
M ayor Harry Kim
received the first
annual Advocate for
Recovery Award in
September, 2004. HSAM
acknowledged Mayor Kim
for his leadership in bringing
attention and resources to
Hawaii’s ice epidemic.
Mayor Kim worked
with community-based
groups and a bi-partisan
political coalition to create
a three-pronged initiative: HSAM past president Dr. Kevin Kunz, left, presents the Advocate for Recovery Award to Mayor Harry Kim in 2004.
enforcement, treatment and
prevention. He organized
the first Ice Summit in every neighborhood in for programs throughout nonpartisan in 2004, has
the state, and secured Hawaii County, encouraged Hawaii. Dr. Kunz notes been asked by the Hawaii
millions of new dollars for and supported grass-roots that Mayor Kim, who was Democratic leadership to
treatment. His “Lets Kick community organizations, elected as a Republican in run for Governor in the
Ice” campaign reached and served as a model 2000, and re-elected as a 2006 elections.
WelCoMe lizA lee
Liza Lee has joined promotion, and a range of Liza is well known for
the HSAM team as other duties. She participates her professionalism,
Administrative Assistant. in a monthly conference attention to detail, upbeat
Liza’s “daytime” job is call with the ASAM positive attitude, and most
Operations Director at national office, and with importantly, her ability to
HMA. Through a contract Administrative Assistants get along with even the
with HMA, she is providing from other states. busiest and grumpiest of
HSAM with the support Recently she attended physicians. She is a real
services needed to keep a two day ASAM chapter asset to HSAM. She can
our chapter going. development meeting in be reached by email or by Ms.Liza Lee, HSAM Administrative
Her duties include the Washington D.C., certainly an phone. If you’re in the HMA Assistant, briefly toured several
scheduling and logistics of indication of her dedication offices, stop by and say Washington landmarks while
attending a 2 day ASAM chapter
meetings, correspondence, to promoting addiction Hello (and Mahalo for a job leadership meeting held after the
bookkeeping, membership medicine in Hawaii. well done!). State of the Art Conference.
Hawai‘i Society of addiction Medicine
Page
State of the Art was associated with an concerning the actual phosphorylation, or the
continued from pg. 1
adolescent’s inability to mechanism of action of inhibition of it, determine
National Institute on Drug concentrate during periods drugs of abuse at the cellular the go-no-go electrical
Abuse (NIDA), expanded of emotional distractions. and molecular level. Dr event of the postsynaptic
on the biology of the “brain This neostriatal theme Greengard brought no less nerve. It is on the receptor
disease” concept asking the that a biochemical cascade
genetic question: “To what involves a second messenger
extent does the addicted of cyclic AMP and cyclic GMP
individual have a choice in for the most part. These
choosing his fate?” second messengers are then
Dr Volkow is somewhat of coupled to the activation
a pocket Hercules, having of protein kinases. Any
written some 275 scientific interruption of this process
articles and more than 50 is bound to have major
book chapters in the field consequences.
of medicine. She was raised Virtually all drugs that
in Mexico. Her father was a are useful in the treatment
scientist of Russian origin of schizophrenia work
and was the grandson of by blocking the ability
Leon Trotsky; the famous of dopamine to activate
revolutionary assassinated a subclass of dopamine
by the long arm of terrorist receptors. ADHD is treated
Russian politics. with methylphenidate, an
Her real accomplishments amphetamine like compound
in addiction medicine that promotes dopaminergic
have been in imaging. But signaling; all known drugs
her theme was distinctly of abuse work through
genetic. The ready this dopamine-signaling
availability of drugs of pathway. And it is the
abuse is an important factor charging and recharging of
and is well documented. a phosphate carrier protein
Beyond this a sense of with its interaction to the then a lifetime of work on in the second messenger
curiosity to take the drug, nucleus accumbens was a the nature of neurological system called DARPP-32
and a personality, and persistent issue throughout transmission and drugs of - an acronym for dopamine
gene set that tends more the conference and has abuse. His work on slow and cyclic AMP regulated
to risky behavior and/or become the anatomical synaptic transmission and its phosphoprotein – that has
vulnerability must intersect focus in addiction medicine. chemical nature has involved become the Rosetta stone
with the ubiquitous This period of vulnerability more than one hundred for studying the interaction
availability. she then coupled with the chemical transmitters. of dopamine signaling. The
She summarized the known, variably deficient We were reminded of the nerves containing these
prolific data showing numbers of D2 dopamine electrical nature of the nerve critical peptides are called
adolescents to be at higher receptors in limbic structures. impulse until it reaches the medium spiny neurons based
risk for addiction then those These data begin to show presynaptic membrane upon their morphology.
who begin drug use later. a picture of genetic and where that energy is These cells project from the
This is well established. She neuro-biologic vulnerability converted to a chemical neostriatal (caudate nucleus
showed data to suggest that might be exploited in event with the release of and the putamen) to the
the immaturity of nerve future research. a neurotransmitter. At the substantia nigra and nucleus
connections between the Nobel Laureate Paul Greengard postsynaptic membrane accumbens integrating all
amygdala and prefrontal Paul Greengard, Ph.D. the transmitter binds the information coming
cortex (one of the last areas summarized a withering to a specific receptor into the neostriatum from
of the brain to develop) amount of biochemistry where a specific protein other parts of the brain. So
Hawai‘i Society of addiction Medicine
Page
there are a whole bunch of the compulsive character potentiation of inhibitory opiate receptor antagonist
nerve cells with deferent of drug seeking in addicts GABA(A) receptors and that initially was approved
neurotransmitters that all by decreasing the value antagonizes excitatory in 1984 for the treatment
converge on the DARPP-32 of natural rewards, glutamatergic afferents of opiate dependence. In
containing neurons, and diminishing cognitive to the corticomesolimbic 1994, the FDA approved
these are the only neurons control (choice), and dopaminergic system. a 50 mg oral tablet for
that can send information enhancing glutamatergic It would appear that it the treatment of alcohol
out of the neostriatum. That drive in response to drug- works through the very dependence. Published in
is, the only efferent pathway. associated stimuli. neurological anatomic the Journal of Studies on
So the function of these cells The session also reviewed system discussed in Dr Alcohol is a review of the
is to integrate a huge amount developmental aspects of Greengard’s lecture. This similarities and differences
of incoming information and implies that this agent may between acamprosate
then send it back out. have potential in treating and naltrexone and a call
The importance of both alcohol and cocaine for a large-scale multi-
this work cannot be dependence. It would not site trial, with evaluation
understated, nor did its only serve to decrease the of potential predictors
significance pass by the acute reinforcing effects of response to each drug
Nobel committee. All of alcohol and possibly of alone and in combination.
drugs of abuse have been addiction. Again, functional cocaine, but might decrease Of note is the increase in
demonstrated to work imaging played important the rate of recidivism blood levels of acamprosate
through this ubiquitous rolls in speculating on by decreasing neuronal when treatment with
molecule DARPP-32 and the mechanism of injury sensitivity in these critical naltrexone in combination.
it’s phosphorylation. In in children with prenatal areas of the brain. The A long acting, deep i.m.
tune with the theory, cocaine exposure. Behnke upshot of these lectures was injection of naltrexone (400
DARPP-32 knockout mice and her group in Gainesville the notion that it might well mg monthly) has been
demonstrate complete loss Florida have demonstrated work in both alcohol and determined to be safe and
of response to dopamine abnormalities in diffusion cocaine abuse. It was clear effective and also awaits
at the D2 receptor. In line tensor imaging of MRI from Dr Johnson’s discussion large multi-center trials.
with this is the failure of scans in 11 year old children that this mechanistic The FDA may approve this
cells to respond to drugs exposed to prenatal formulation by the end of
of abuse, as they fail to cocaine, suggesting micro- the year.
act through the DARPP- structural alterations in Endocannabinoid System
32 carrier system. If not frontal white matter. These In addition to
easy to understand in effects correlate with poorer direct stimulation of
detail, it is important to performance in the executive dopamine release in the
understand in conception. function, defined as brain’s reward center,
Dr. Greengard stated that cognitive planning, impulse chronic nicotine use
there are 4 known diseases control and organization. hyper-stimulates the
of dopamine deficiency: Topiramate & Acamprosate argument supported a large endocannabinoid system
Parkinson’s Disease, Session 3 was about multi-center study as soon as (ECS). This recently
schizophrenia, ADHA, and topiramate, naltrexone and possible. Indeed, he seemed identified system is an
drug addiction. other agents that modify to encourage it’s continued important modulator of
More Brain Studies neurochemical events in off label use if for no other nicotine reinforcement,
During the next the striatum and related reason than it’s known safety food intake and energy
session Peter Kalivas, structures. Topiramate has and efficacy record. balance. The first
Ph.D. showed rat data been used off label for the Growing acceptability selective antagonist of
strongly supporting treatment of alcoholism. of both naltrexone and the type 1 cannabinoid
cellular adaptations in Though not yet approved acamprosate used as single or CB1 receptor has been
prefrontal glutamatergic for use, it was discussed agents lead to a proposal identified. Rimonabant
innervations of the nucleus at length. This agent that both agents be used has been found in clinical
accumbens promoting probably works through the together. Naltrexone is an ART ~continued on pg. 6
Hawai‘i Society of addiction Medicine
Page
State of the Art alcoholics are the same.
continued from pg. 5
trials to augment smoking
The genetic basis for this
deference is exploitable. It ASAM ASkS hAWAii
cessation, prevent relapse
to smoking, and markedly
reduce post-cessation
is well known, for example,
that early onset alcoholics
show a clear difference in
SuPreMe Court to
weight gain.
Pharmacogenomics
their response to the mu
blocking drug naltrexone
reverSe iCe deAth
Pharmacogenomics was
a complete session in itself
than late onset alcoholics.
Johnson brought up the
unexpected results that early
ConviCtion
and introduced a number
In June 2004, Tayshea and violates the well-
Aiwohi pleaded no- established consensus in
contest to manslaughter in the medical community
the death of her two-day- that such prosecution
old son. The child, born is irrational, ineffective,
4 weeks premature, died and counterproductive
from methamphetamine to maternal, fetal and
toxicity, and Ms. Aiwohi, newborn health.
a 31 year-old Native “Punishing women for
Hawaiian, had testified failing to have healthy
of topics on the horizon onset alcoholics actually got that she smoked ice three pregnancy outcomes
for clinicians, who may worse when treated with days before, and on the undermines health
find some trouble on the SSRI’s where as late onset day of, her son’s birth. care for both pregnant
application of this esoteric alcoholics did not. Follow Her conviction is now women and their future
subject. The science itself is up work with the Asn40Asp on appeal to the Hawaii children by frightening
most easily defined as the gene variant demonstrated Supreme Court, which women away from that
merging of pharmacology that men with this genetic heard oral arguments health care,” said Leslie
and genetics. Now that pattern demonstrated in October, 2005. The Hartley Gise, MD, Clinical
the genome is known a similar pattern when American Society of Professor of Psychiatry,
there is increasing interest alcoholics from both Addiction Medicine John A. Burns School of
in the small areas of DNA groups were treated with joined sixty other national Medicine, University Of
that are different. Single naltrexone. This has served organizations and Hawaii. Dr. Gise added
nucleotide polymorphisms, to explain the variability of individuals in an amicus that, “Suggesting that
SNPs or “snips” as they are success in alcoholics. (friend of the court) brief a pregnant woman
called, provide for genetic There are many agents asking that the conviction who is struggling with
difference in individuals not discussed here that be overturned. a drug dependency
that may be exploitable. are in the pike. This is Ms. Aiwohi is the first problem is no different
By looking at small really an exciting area and woman in Hawaii to be from a man who attacks
areas of variations called one that deserves our charged and convicted her, reflects a terrible
SNPs there is mounting attention. Unifying theories of manslaughter based disregard for pregnant
evidence that these areas of the microanatomy on the theory that women and a profound
give rise to differences in and biochemistry of the pregnant women can be misunderstanding
phenotypic drug response. central nervous system held criminally liable for of the nature of drug
That assumes one knows will provide the framework the outcomes of their dependency.”
something about these needed for the many new pregnancies. ASAM ASAM and the other
various alleles. Bankole tools we clinicians will and others argue that Amici explain in the
Johnson, Ph.D. from the require to treat this chronic, this conviction is not brief that the problems
University of Virginia relapsing and all to often authorized by Hawaii law posed by drug use in
pointed out that not all fatal disease.
Hawai‘i Society of addiction Medicine
Page
hSAM Co-SPonSorS PhySiCiAnS
heAlth ConferenCe
D r. Gerald McKenna,
an HSAM founding
member and Chair of the
in October at the Turtle
Bay Hotel in Kahuku, Oahu.
The conference was co-
day event, which was
considered by the attendees
an overwhelming success.
Legislative/Public Policy sponsored by the HMA, Approximately 40 mainland
Committee, co-chaired HSAM and the Montana physicians attended, and
the Western Regional Physicians Health Program. seemed to enjoy the venue
Conference of State Several local physicians – which fortunately had it’s
Physician Health Programs attended the two- usual perfect weather.
pregnancy are serious
public health issues but
condemn the arrest and
prosecution of pregnant
women because drug
hSAM MeMberS viSit ConGreSS
dependency is a disease Three HSAM treatment, reviewed the One notable outcome of
not a crime; because such members took to role of addiction physicians the visit was an invitation
prosecutions are likely to Capitol Hill on October in providing treatment to provide testimony to
deter pregnant women 26, 2005, to educate in Hawaii. The key issue the Senate Committee
from seeking prenatal care Hawaii’s Congressional addressed was support on Veterans Affairs in
and treatment for drug representatives about of parity for addiction January. Included in the
and alcohol addiction that both the value of addiction treatment. HSAM and planned testimony will
is beneficial to them and medicine in treating ASAM are asking for be a review of the need
their children; and because substance use disorders and support for two pieces for more substance abuse
such punitive approaches HSAM’s mission to expand of parity legislation: the services and personnel in
have no proven benefits for access to treatment. Drs. HEART Act (S.803) and Hawaii, particularly on the
the health of children. Batzer, Kunz and Linden met the TREAT America Act neighbor islands. Interested
Other organizations directly with Representative (HR. 1258). Both acts physicians should contact
signing onto the Amicus Neil Abercrombie, and with provide parity in health Dr. Kunz.
brief included ACOG, APA, staff members of Senator insurance coverage for The only glitch in the visits
National Advocates for Inouye, Senator Akaka, and substance abuse treatment. happened mid-day, after
Pregnant Women, and Representative Ed Case. Specifically, they prohibit the visit to Senator Inouye’s
the Hawaii Chapter of the The Hawaii physicians group health plans from office. One of the Senator’s
National Association of began the day with a imposing discriminatory staffers inadvertently left
Social Workers. In addition briefing from Dr. Nora annual/lifetime dollar the meeting with all of
to Dr. Gise, three other Volkow, Director of NIDA limits, copays and Dr. Batzer’s paperwork
Hawaii individuals joined and renowned leader in deductibles, or day and – briefing documents as
the brief: Jennifer Frank, addiction research. Later, visit limits unless similar well as the day’s schedule!
MD, University of Hawaii; they were indoctrinated limitations or requirements In a scene reminiscent of
Kathleen Irwin, PhD, to Capitol Hill etiquette by are imposed for other the Wizard of Oz, the three
Department of Sociology, Ms. Carol McDaid, Principal medical and surgical Hawaii physicians stood
University of Hawaii; and of Capitol Decisions, a benefits. More details on perplexed and bewildered
Mona Bomgaars, MD, legislative consultant firm. these bills, progress thru in the large atrium of the
Hawaii Academy of Family When visiting the Congress, and ways you can Senate Office Building,
Physicians. Congressional offices, support them can be found getting re-oriented and
the trio first offered an on the ASAM Advocacy planning the next move in a
overview of the disease & Government Relations strange land.
concept of addiction website (www.asam.org/
and the effectiveness of advocacy/Advocacy.htm).
Hawai‘i Society of addiction Medicine
Page
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American Society of Addiction Medicine
P.O. Box 80139 • Baltimore, Maryland • 21280-0139
Phone: 301-656-3920 • Fax: 301-656-3815 • www.asam.org • email@asam.org
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