Common Name: CACODYLIC ACID
CAS Number: 75-60-5 RTK Substance number: 0304
DOT Number: UN 1572 Date: January 1999
* Cacodylic Acid can affect you when breathed in and by * If you think you are experiencing any work-related health
passing through your skin. problems, see a doctor trained to recognize occupational
* Skin contact can cause irritation, burning, itching, diseases. Take this Fact Sheet with you.
thickening and color changes.
* Eye contact may cause irritation and burns. WORKPLACE EXPOSURE LIMITS
* Breathing Cacodylic Acid can irritate the nose and throat The following exposure limits are for organic Arsenic
and may cause ulcers and/or a hole in the “bone” dividing compounds (measured as Arsenic):
the inner nose.
* Repeated exposure can cause a metallic or garlic taste, OSHA: The legal airborne permissible exposure limit
poor appetite, nausea and vomiting, difficulty swallowing, (PEL) is 0.5 mg/m3 averaged over an 8-hour
stomach pain, diarrhea, seizures and death. workshift.
* High or repeated exposure may damage the nerves causing
weakness, "pins and needles," and poor coordination in the * The above exposure limit is for air levels only. When skin
arms and legs. contact also occurs, you may be overexposed, even though
* Cacodylic Acid may damage the liver. air levels are less than the limit listed above.
IDENTIFICATION WAYS OF REDUCING EXPOSURE
Cacodylic Acid is an Arsenic compound. It is a colorless, * Where possible, enclose operations and use local exhaust
odorless, crystalline (sand-like) solid used as an herbicide and ventilation at the site of chemical release. If local exhaust
soil sterilant. It is also used in chemical warfare and in timber ventilation or enclosure is not used, respirators should be
* Wear protective work clothing.
REASON FOR CITATION * Wash thoroughly immediately after exposure to Cacodylic
* Cacodylic Acid is on the Hazardous Substance List Acid and at the end of the workshift.
because it is regulated by OSHA and cited by DOT, * Post hazard and warning information in the work area. In
HHAG and EPA. addition, as part of an ongoing education and training
* Definitions are provided on page 5. effort, communicate all information on the health and
safety hazards of Cacodylic Acid to potentially exposed
HOW TO DETERMINE IF YOU ARE BEING workers.
The New Jersey Right to Know Act requires most employers
to label chemicals in the workplace and requires public
employers to provide their employees with information and
training concerning chemical hazards and controls. The
federal OSHA Hazard Communication Standard, 1910.1200,
requires private employers to provide similar training and
information to their employees.
* Exposure to hazardous substances should be routinely
evaluated. This may include collecting personal and area
air samples. You can obtain copies of sampling results
from your employer. You have a legal right to this
information under OSHA 1910.1020.
CACODYLIC ACID page 2 of 6
This Fact Sheet is a summary source of information of all they are most accurate at the end of a workday. At NIOSH
potential and most severe health hazards that may result from recommended exposure levels, urine Arsenic should not be
exposure. Duration of exposure, concentration of the greater than 100 micrograms per gram of Creatinine in
substance and other factors will affect your susceptibility to the urine.
any of the potential effects described below.
----------------------------------------------------------------------------- After suspected overexposure, repeat these tests. Also,
examine your skin periodically for abnormal growths. Skin
HEALTH HAZARD INFORMATION cancer from Arsenic is often cured when detected early.
Acute Health Effects Any evaluation should include a careful history of past and
The following acute (short-term) health effects may occur present symptoms with an exam. Medical tests that look for
immediately or shortly after exposure to Cacodylic Acid: damage already done are not a substitute for controlling
* Skin contact can cause irritation, burning, itching,
thickening and color changes. Request copies of your medical testing. You have a legal right
* Eye contact may cause irritation and burns. to this information under OSHA 1910.1020.
* Breathing Cacodylic Acid can irritate the nose and throat
causing coughing and wheezing. Mixed Exposures
* Repeated exposure can cause a metallic or garlic taste, * Because more than light alcohol consumption can cause
poor appetite, nausea and vomiting, difficulty swallowing, liver damage, drinking alcohol can increase the liver
stomach pain, diarrhea, seizures and death. damage caused by Cacodylic Acid.
Chronic Health Effects WORKPLACE CONTROLS AND PRACTICES
The following chronic (long-term) health effects can occur at
some time after exposure to Cacodylic Acid and can last for Unless a less toxic chemical can be substituted for a hazardous
months or years: substance, ENGINEERING CONTROLS are the most
effective way of reducing exposure. The best protection is to
Cancer Hazard enclose operations and/or provide local exhaust ventilation at
* While Cacodylic Acid has not been identified as a the site of chemical release. Isolating operations can also
carcinogen, Arsenic and certain Arsenic compounds have reduce exposure. Using respirators or protective equipment is
been determined to be human carcinogens. Cacodylic Acid less effective than the controls mentioned above, but is
should be handled with extreme caution. sometimes necessary.
Reproductive Hazard In evaluating the controls present in your workplace, consider:
* There is limited evidence that Cacodylic Acid is a (1) how hazardous the substance is, (2) how much of the
teratogen in animals. Until further testing has been done, it substance is released into the workplace and (3) whether
should be treated as a possible teratogen in humans. harmful skin or eye contact could occur. Special controls
should be in place for highly toxic chemicals or when
Other Long-Term Effects significant skin, eye, or breathing exposures are possible.
* Long term exposure can cause an ulcer or hole in the
“bone” dividing the inner nose. Hoarseness and sore eyes In addition, the following control is recommended:
* Repeated skin contact can cause thickened skin and/or * Where possible, automatically transfer Cacodylic Acid
patchy areas of darkening and loss of pigment. Some from drums or other storage containers to process
persons develop white lines on the nails. containers.
* High or repeated exposure may damage the nerves causing
weakness, "pins and needles," and poor coordination in the Good WORK PRACTICES can help to reduce hazardous
arms and legs. exposures. The following work practices are recommended:
* Cacodylic Acid may damage the liver.
* Workers whose clothing has been contaminated by
MEDICAL Cacodylic Acid should change into clean clothing
* Do not take contaminated work clothes home. Family
If symptoms develop or overexposure is suspected, the members could be exposed.
following is recommended: * Contaminated work clothes should be laundered by
individuals who have been informed of the hazards of
* Test for urine Arsenic (fish and shellfish contain Arsenic exposure to Cacodylic Acid.
and may cause an increase in urine Arsenic). Results may * Eye wash fountains should be provided in the immediate
not be accurate within 2 days of eating shellfish or fish; work area for emergency use.
CACODYLIC ACID page 3 of 6
* If there is the possibility of skin exposure, emergency * Where the potential exists for exposure over 0.5 mg/m3 (of
shower facilities should be provided. Arsenic), use a MSHA/NIOSH approved supplied-air
* On skin contact with Cacodylic Acid, immediately wash or respirator with a full facepiece operated in a pressure-
shower to remove the chemical. At the end of the demand or other positive-pressure mode. For increased
workshift, wash any areas of the body that may have protection use in combination with an auxiliary self-
contacted Cacodylic Acid, whether or not known skin contained breathing apparatus operated in a pressure-
contact has occurred. demand or other positive-pressure mode.
* Do not eat, smoke, or drink where Cacodylic Acid is
handled, processed, or stored, since the chemical can be HANDLING AND STORAGE
swallowed. Wash hands carefully before eating, drinking,
smoking, or using the toilet. * Prior to working with Cacodylic Acid you should be
* Use a vacuum or a wet method to reduce dust during clean- trained on its proper handling and storage.
up. DO NOT DRY SWEEP. * When in water solution, Cacodylic Acid must be stored to
avoid contact with CHEMICALLY ACTIVE METALS
PERSONAL PROTECTIVE EQUIPMENT (such as POTASSIUM, SODIUM, MAGNESIUM, IRON,
ALUMINUM and ZINC) since violent reactions occur and
WORKPLACE CONTROLS ARE BETTER THAN highly toxic fumes of Arsenic are released.
PERSONAL PROTECTIVE EQUIPMENT. However, for * Cacodylic Acid is not compatible with OXIDIZING
some jobs (such as outside work, confined space entry, jobs AGENTS (such as PERCHLORATES, PEROXIDES,
done only once in a while, or jobs done while workplace PERMANGANATES, CHLORATES, NITRATES,
controls are being installed), personal protective equipment CHLORINE, BROMINE and FLUORINE); STRONG
may be appropriate. BASES (such as SODIUM HYDROXIDE and
POTASSIUM HYDROXIDE); and REDUCING
OSHA 1910.132 requires employers to determine the AGENTS.
appropriate personal protective equipment for each hazard and * Store in tightly closed containers in a cool, well-ventilated
to train employees on how and when to use protective area away from MOISTURE, FERTILIZERS, SEEDS,
equipment. INSECTICIDES, or FUNGICIDES.
The following recommendations are only guidelines and may QUESTIONS AND ANSWERS
not apply to every situation.
Q: If I have acute health effects, will I later get chronic
Clothing health effects?
* Avoid skin contact with Cacodylic Acid. Wear protective A: Not always. Most chronic (long-term) effects result from
gloves and clothing. Safety equipment repeated exposures to a chemical.
suppliers/manufacturers can provide recommendations on
the most protective glove/clothing material for your Q: Can I get long-term effects without ever having short-
operation. term effects?
* All protective clothing (suits, gloves, footwear, headgear) A: Yes, because long-term effects can occur from repeated
should be clean, available each day, and put on before exposures to a chemical at levels not high enough to
work. make you immediately sick.
Q: What are my chances of getting sick when I have been
Eye Protection exposed to chemicals?
* Wear impact resistant eye protection with side shields or A: The likelihood of becoming sick from chemicals is
goggles. increased as the amount of exposure increases. This is
* Wear a face shield along with goggles when working with determined by the length of time and the amount of
corrosive, highly irritating or toxic substances. material to which someone is exposed.
Respiratory Protection Q: When are higher exposures more likely?
IMPROPER USE OF RESPIRATORS IS DANGEROUS. A: Conditions which increase risk of exposure include dust
Such equipment should only be used if the employer has a releasing operations (grinding, mixing, blasting,
written program that takes into account workplace conditions, dumping, etc.), physical and mechanical processes
requirements for worker training, respirator fit testing and (heating, pouring, spraying, spills and evaporation from
medical exams, as described in OSHA 1910.134. large surface areas such as open containers), and
"confined space" exposures (working inside vats,
* For field applications check with your supervisor and your reactors, boilers, small rooms, etc.).
safety equipment supplier regarding the appropriate
CACODYLIC ACID page 4 of 6
Q: Is the risk of getting sick higher for workers than for -----------------------------------------------------------------------------
community residents? The following information is available from:
A: Yes. Exposures in the community, except possibly in
cases of fires or spills, are usually much lower than those New Jersey Department of Health and Senior Services
found in the workplace. However, people in the Occupational Disease and Injury Services
community may be exposed to contaminated water as PO Box 360
well as to chemicals in the air over long periods. This Trenton, NJ 08625-0360
may be a problem for children or people who are already (609) 984-1863
ill. (609) 292-5677 (fax)
Q: Should I be concerned if a chemical is a teratogen in Web address: http://www.state.nj.us/health/eoh/odisweb/
A: Yes. Although some chemicals may affect humans Industrial Hygiene Information
differently than they affect animals, damage to animals Industrial hygienists are available to answer your questions
suggests that similar damage can occur in humans. regarding the control of chemical exposures using exhaust
ventilation, special work practices, good housekeeping, good
hygiene practices, and personal protective equipment including
respirators. In addition, they can help to interpret the results of
industrial hygiene survey data.
If you think you are becoming sick because of exposure to
chemicals at your workplace, you may call personnel at the
Department of Health and Senior Services, Occupational
Disease and Injury Services, who can help you find the
information you need.
Presentations and educational programs on occupational health
or the Right to Know Act can be organized for labor unions,
trade associations and other groups.
Right to Know Information Resources
The Right to Know Infoline (609) 984-2202 can answer
questions about the identity and potential health effects of
chemicals, list of educational materials in occupational health,
references used to prepare the Fact Sheets, preparation of the
Right to Know survey, education and training programs,
labeling requirements, and general information regarding the
Right to Know Act. Violations of the law should be reported
to (609) 984-2202.
CACODYLIC ACID page 5 of 6
ACGIH is the American Conference of Governmental A mutagen is a substance that causes mutations. A mutation
Industrial Hygienists. It recommends upper limits (called is a change in the genetic material in a body cell. Mutations
TLVs) for exposure to workplace chemicals. can lead to birth defects, miscarriages, or cancer.
A carcinogen is a substance that causes cancer. NAERG is the North American Emergency Response
Guidebook. It was jointly developed by Transport Canada, the
The CAS number is assigned by the Chemical Abstracts United States Department of Transportation and the Secretariat
Service to identify a specific chemical. of Communications and Transportation of Mexico. It is a
guide for first responders to quickly identify the specific or
A combustible substance is a solid, liquid or gas that will generic hazards of material involved in a transportation
burn. incident, and to protect themselves and the general public
during the initial response phase of the incident.
A corrosive substance is a gas, liquid or solid that causes
irreversible damage to human tissue or containers. NCI is the National Cancer Institute, a federal agency that
determines the cancer-causing potential of chemicals.
DEP is the New Jersey Department of Environmental
Protection. NFPA is the National Fire Protection Association. It classifies
substances according to their fire and explosion hazard.
DOT is the Department of Transportation, the federal agency
that regulates the transportation of chemicals. NIOSH is the National Institute for Occupational Safety and
Health. It tests equipment, evaluates and approves respirators,
EPA is the Environmental Protection Agency, the federal conducts studies of workplace hazards, and proposes standards
agency responsible for regulating environmental hazards. to OSHA.
A fetus is an unborn human or animal. NTP is the National Toxicology Program which tests
chemicals and reviews evidence for cancer.
A flammable substance is a solid, liquid, vapor or gas that will
ignite easily and burn rapidly. OSHA is the Occupational Safety and Health Administration,
which adopts and enforces health and safety standards.
The flash point is the temperature at which a liquid or solid
gives off vapor that can form a flammable mixture with air. PEOSHA is the Public Employees Occupational Safety and
Health Act, a state law which sets PELs for New Jersey public
HHAG is the Human Health Assessment Group of the federal employees.
ppm means parts of a substance per million parts of air. It is a
IARC is the International Agency for Research on Cancer, a measure of concentration by volume in air.
scientific group that classifies chemicals according to their
cancer-causing potential. A reactive substance is a solid, liquid or gas that releases
energy under certain conditions.
A miscible substance is a liquid or gas that will evenly
dissolve in another. A teratogen is a substance that causes birth defects by
damaging the fetus.
mg/m3 means milligrams of a chemical in a cubic meter of air.
It is a measure of concentration (weight/volume). TLV is the Threshold Limit Value, the workplace exposure
limit recommended by ACGIH.
MSHA is the Mine Safety and Health Administration, the
federal agency that regulates mining. It also evaluates and The vapor pressure is a measure of how readily a liquid or a
approves respirators. solid mixes with air at its surface. A higher vapor pressure
indicates a higher concentration of the substance in air and
therefore increases the likelihood of breathing it in.
page 6 of 6
>>>>>>>>>>>>>>>>> E M E R G E N C Y I N F O R M A T I O N <<<<<<<<<<<<<<<<<
Common Name: CACODYLIC ACID HANDLING AND STORAGE (See page 3)
DOT Number: UN 1572
NAERG Code: 151 FIRST AID
CAS Number: 75-60-5
In NJ, POISON INFORMATION 1-800-764-7661
Hazard rating NJDHSS NFPA
Not Found Not Rated
FLAMMABILITY * Immediately flush with large amounts of water for at least 15
REACTIVITY Not Found Not Rated minutes, occasionally lifting upper and lower lids. Seek
POISONOUS GASES ARE PRODUCED IN FIRE medical attention immediately.
CONTAINERS MAY EXPLODE IN FIRE
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; * Quickly remove contaminated clothing. Immediately wash
3=serious; 4=severe contaminated skin with large amounts of soap and water.
Seek medical attention if symptoms persist.
* Cacodylic Acid may burn, but does not readily ignite. Breathing
* Use dry chemical, CO2, water spray, or alcohol or polymer * Remove the person from exposure.
foam extinguishers. * Begin rescue breathing (using universal precautions) if
* POISONOUS GASES ARE PRODUCED IN FIRE, breathing has stopped and CPR if heart action has stopped.
including Carbon Monoxide and Arsenic Oxides. * Transfer promptly to a medical facility.
* CONTAINERS MAY EXPLODE IN FIRE.
* Use water spray to keep fire-exposed containers cool. PHYSICAL DATA
* If employees are expected to fight fires, they must be trained
and equipped as stated in OSHA 1910.156. Water Solubility: Soluble
SPILLS AND EMERGENCIES OTHER COMMONLY USED NAMES
If Cacodylic Acid is spilled, take the following steps: Chemical Name:
Arsenic Acid, Dimethyl-
* Evacuate persons not wearing protective equipment from Other Names:
area of spill or leak until clean-up is complete.
Ansar; Hydroxydimethylarsine Oxide; Dimethylarsinic Acid
* Collect powdered material in the most convenient and safe
manner and deposit in sealed containers.
* Ventilate after clean-up is complete.
* It may be necessary to contain and dispose of Cacodylic
Not intended to be copied and sold for commercial
Acid as a HAZARDOUS WASTE. Contact your purposes.
Department of Environmental Protection (DEP) or your -----------------------------------------------------------------------------
regional office of the federal Environmental Protection NEW JERSEY DEPARTMENT OF HEALTH AND
Agency (EPA) for specific recommendations. SENIOR SERVICES
* If employees are required to clean-up spills, they must be Right to Know Program
properly trained and equipped. OSHA 1910.120(q) may be PO Box 368, Trenton, NJ 08625-0368
applicable. (609) 984-2202
FOR LARGE SPILLS AND FIRES immediately call your fire
department. You can request emergency information from the
CHEMTREC: (800) 424-9300
NJDEP HOTLINE: (609) 292-7172