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CTCAE_4.02_2009-10-06.xls - ACRI

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CTCAE_4.02_2009-10-06.xls - ACRI Powered By Docstoc
					 MedDRA
v12.0 Code      CTCAE v4.0 SOC        CTCAE v4.0 Term                   Grade 1


                                                            Hemoglobin (Hgb) <LLN -
             Blood and lymphatic                            10.0 g/dL; <LLN - 6.2 mmol/L;
10002272     system disorders      Anemia                   <LLN - 100 g/L


                                                            Mildly hypocellular or <=25%
             Blood and lymphatic   Bone marrow              reduction from normal
10048580     system disorders      hypocellular             cellularity for age


             Blood and lymphatic   Disseminated
10013442     system disorders      intravascular coagulation -

             Blood and lymphatic
10016288     system disorders      Febrile neutropenia       -

                                                            Laboratory evidence of
                                                            hemolysis only (e.g., direct
                                                            antiglobulin test; DAT;
             Blood and lymphatic                            Coombs'; schistocytes;
10019491     system disorders      Hemolysis                decreased haptoglobin)


                                                            Evidence of RBC destruction
             Blood and lymphatic   Hemolytic uremic         (schistocytosis) without
10019515     system disorders      syndrome                 clinical consequences

             Blood and lymphatic
10024378     system disorders      Leukocytosis              -

             Blood and lymphatic
10025182     system disorders      Lymph node pain          Mild pain

                                                            Incidental findings (e.g.,
                                                            Howell-Jolly bodies); mild
             Blood and lymphatic                            degree of thrombocytosis
10041633     system disorders      Spleen disorder          and leukocytosis


                                   Thrombotic               Evidence of RBC destruction
             Blood and lymphatic   thrombocytopenic         (schistocytosis) without
10043648     system disorders      purpura                  clinical consequences
                                                           Asymptomatic or mild
                                 Blood and lymphatic       symptoms; clinical or
           Blood and lymphatic   system disorders - Other, diagnostic observations only;
10005329   system disorders      specify                   intervention not indicated




                                 Acute coronary
10051592   Cardiac disorders     syndrome                  -


                                                           Asymptomatic valvular
                                                           thickening with or without
                                                           mild valvular regurgitation or
10061589   Cardiac disorders     Aortic valve disease      stenosis by imaging
                                                           Periods of asystole; non-
                                                           urgent medical management
10003586   Cardiac disorders     Asystole                  indicated




                                                           Asymptomatic, intervention
10003658   Cardiac disorders     Atrial fibrillation       not indicated




                                                           Asymptomatic, intervention
10003662   Cardiac disorders     Atrial flutter            not indicated




                                 Atrioventricular block
10003673   Cardiac disorders     complete


                                 Atrioventricular block    Asymptomatic, intervention
10003674   Cardiac disorders     first degree              not indicated


10007515   Cardiac disorders     Cardiac arrest            -
10008481   Cardiac disorders   Chest pain - cardiac        Mild pain

                                                           Mild symptoms; intervention
10010276   Cardiac disorders   Conduction disorder         not indicated




10010783   Cardiac disorders   Constrictive pericarditis   -


                                                           Asymptomatic with
                                                           laboratory (e.g., BNP [B-
                                                           Natriuretic Peptide ]) or
10019279   Cardiac disorders   Heart failure               cardiac imaging abnormalities




                               Left ventricular systolic
10069501   Cardiac disorders   dysfunction                 -


                                                           Asymptomatic valvular
                                                           thickening with or without
                                                           mild valvular regurgitation or
10061532   Cardiac disorders   Mitral valve disease        stenosis by imaging




                               Mobitz (type) II            Asymptomatic, intervention
10027786   Cardiac disorders   atrioventricular block      not indicated




                                                           Asymptomatic, intervention
10027787   Cardiac disorders   Mobitz type I               not indicated




10028596   Cardiac disorders   Myocardial infarction       -
                                                        Asymptomatic with
                                                        laboratory (e.g., BNP [B-
                                                        Natriuretic Peptide ]) or
10028606   Cardiac disorders   Myocarditis              cardiac imaging abnormalities

                                                        Mild symptoms; intervention
10033557   Cardiac disorders   Palpitations             not indicated




                               Paroxysmal atrial        Asymptomatic, intervention
10034040   Cardiac disorders   tachycardia              not indicated


10034474   Cardiac disorders   Pericardial effusion      -


10053565   Cardiac disorders   Pericardial tamponade     -

                                                        Asymptomatic, ECG or
                                                        physical findings (e.g., rub)
10034484   Cardiac disorders   Pericarditis             consistent with pericarditis


                                                       Asymptomatic valvular
                                                       thickening with or without
                                                       mild valvular regurgitation or
10061541   Cardiac disorders   Pulmonary valve disease stenosis by imaging


                               Restrictive
10038748   Cardiac disorders   cardiomyopathy            -


                                                        Asymptomatic with
                                                        laboratory (e.g., BNP [B-
                               Right ventricular        Natriuretic Peptide ]) or
10058597   Cardiac disorders   dysfunction              cardiac imaging abnormalities

                                                        Asymptomatic, intervention
10040639   Cardiac disorders   Sick sinus syndrome      not indicated

                                                        Asymptomatic, intervention
10040741   Cardiac disorders   Sinus bradycardia        not indicated
                                                          Asymptomatic, intervention
10040752   Cardiac disorders   Sinus tachycardia          not indicated

                               Supraventricular           Asymptomatic, intervention
10042604   Cardiac disorders   tachycardia                not indicated


                                                          Asymptomatic valvular
                                                          thickening with or without
                                                          mild valvular regurgitation or
10061389   Cardiac disorders   Tricuspid valve disease    stenosis




                                                          Asymptomatic, intervention
10047281   Cardiac disorders   Ventricular arrhythmia     not indicated




10047290   Cardiac disorders   Ventricular fibrillation   -




10047302   Cardiac disorders   Ventricular tachycardia    -


                               Wolff-Parkinson-White      Asymptomatic, intervention
10048015   Cardiac disorders   syndrome                   not indicated




                                                          Asymptomatic or mild
                                                          symptoms; clinical or
                               Cardiac disorders - Other, diagnostic observations only;
10007541   Cardiac disorders   specify                    intervention not indicated
                                                               Asymptomatic or mild
                                    Congenital, familial and symptoms; clinical or
           Congenital, familial and genetic disorders - Other, diagnostic observations only;
10010331   genetic disorders        specify                    intervention not indicated

           Ear and labyrinth
10014020   disorders                Ear pain                  Mild pain




           Ear and labyrinth        External ear              External otitis with erythema
10065837   disorders                inflammation              or dry desquamation

           Ear and labyrinth
10065785   disorders                External ear pain         Mild pain
                                                         Adults enrolled on a
                                                         monitoring program (a 1, 2,
                                                         3, 4, 6 and 8 kHz audiogram):
                                                         threshold shift of 15 - 25 dB
                                                         averaged at 2 contiguous test
                                                         frequencies in at least one
                                                         ear or subjective change in
                                                         the absence of a Grade 1
                                                         threshold shift

                                                         Pediatric (a 1, 2, 3, 4, 6 and 8
                                                         kHz audiogram): >20 dB at
                                                         any frequency tested and
           Ear and labyrinth                             does not meet criteria for
10019245   disorders           Hearing impaired          >Grade 2

           Ear and labyrinth
10065838   disorders           Middle ear inflammation Serous otitis

           Ear and labyrinth                             Mild symptoms; intervention
10043882   disorders           Tinnitus                  not indicated

           Ear and labyrinth
10047340   disorders           Vertigo                   Mild symptoms

           Ear and labyrinth
10047386   disorders           Vestibular disorder        -




                                                          Asymptomatic or mild
                                                          symptoms; clinical or
           Ear and labyrinth   Ear and labyrinth          diagnostic observations only;
10013993   disorders           disorders - Other, specify intervention not indicated
                                                         Asymptomatic; clinical or
                                                         diagnostic observations only;
10001367   Endocrine disorders   Adrenal insufficiency   intervention not indicated


                                                         Mild symptoms; intervention
10011655   Endocrine disorders   Cushingoid              not indicated




10012205   Endocrine disorders   Delayed puberty         -




10018746   Endocrine disorders   Growth accelerated      -

                                                         Mild symptoms; intervention
10020705   Endocrine disorders   Hyperparathyroidism     not indicated

                                                         Asymptomatic; clinical or
                                                         diagnostic observations only;
10020850   Endocrine disorders   Hyperthyroidism         intervention not indicated

                                                         Asymptomatic; clinical or
                                                         diagnostic observations only;
10021041   Endocrine disorders   Hypoparathyroidism      intervention not indicated

                                                         Asymptomatic; clinical or
                                                         diagnostic observations only;
10021114   Endocrine disorders   Hypothyroidism          intervention not indicated

                                                         Physical signs of puberty with
                                                         no biochemical markers for
                                                         females <8 years and males
10058084   Endocrine disorders   Precocious puberty      <9 years

                                                         Mild symptoms; intervention
10047488   Endocrine disorders   Virilization            not indicated
                                                            Asymptomatic or mild
                                                            symptoms; clinical or
                                 Endocrine disorders -      diagnostic observations only;
10014698   Endocrine disorders   Other, specify             intervention not indicated


10005886   Eye disorders         Blurred vision             Intervention not indicated




                                                            Asymptomatic; clinical or
                                                            diagnostic observations only;
10007739   Eye disorders         Cataract                   intervention not indicated


                                                            Asymptomatic or mild
                                                            symptoms; intervention not
10010741   Eye disorders         Conjunctivitis             indicated




10048492   Eye disorders         Corneal ulcer               -
                                                            Asymptomatic; clinical or
                                                            diagnostic observations only;
                                                            mild symptoms relieved by
10013774   Eye disorders         Dry eye                    lubricants

                                 Extraocular muscle         Asymptomatic; clinical or
10015829   Eye disorders         paresis                    diagnostic observations only


10015958   Eye disorders         Eye pain                   Mild pain


                                                            Asymptomatic; clinical or
                                                            diagnostic observations only;
10061145   Eye disorders         Eyelid function disorder   intervention not indicated
                                                            Symptomatic but not limiting
10016757   Eye disorders         Flashing lights            ADL
                                                    Symptomatic but not limiting
10016778   Eye disorders   Floaters                 ADL




                                                    Elevated intraocular pressure
                                                    (EIOP) with single topical
                                                    agent for intervention; no
10018304   Eye disorders   Glaucoma                 visual field deficit




10023332   Eye disorders   Keratitis                 -

                                                    Symptomatic but not limiting
10029404   Eye disorders   Night blindness          ADL


                                                    Asymptomatic; clinical or
10061322   Eye disorders   Optic nerve disorder     diagnostic observations only




                                                    Asymptomatic; no visual field
10033703   Eye disorders   Papilledema              defects
                                                    Symptomatic but not limiting
10034960   Eye disorders   Photophobia              ADL




10038848   Eye disorders   Retinal detachment       Asymptomatic


10038897   Eye disorders   Retinal tear              -


10038901   Eye disorders   Retinal vascular disorder -
                                                       Asymptomatic; clinical or
10038923   Eye disorders      Retinopathy              diagnostic observations only




                                                       Asymptomatic; clinical or
10061510   Eye disorders      Scleral disorder         diagnostic observations only

                                                       Asymptomatic; clinical or
10046851   Eye disorders      Uveitis                  diagnostic observations only

                                                       Asymptomatic or mild
                                                       symptoms; clinical or
10047656   Eye disorders      Vitreous hemorrhage      diagnostic observations only

10047848   Eye disorders      Watering eyes            Intervention not indicated




                                                       Asymptomatic or mild
                                                       symptoms; clinical or
                              Eye disorders - Other,   diagnostic observations only;
10015919   Eye disorders      specify                  intervention not indicated

                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10000060   disorders          Abdominal distension     intervention not indicated

           Gastrointestinal
10000081   disorders          Abdominal pain           Mild pain




                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10002156   disorders          Anal fistula             intervention not indicated




           Gastrointestinal                            Mild; intervention not
10055226   disorders          Anal hemorrhage          indicated
                                                 Asymptomatic or mild
           Gastrointestinal                      symptoms; intervention not
10065721   disorders          Anal mucositis     indicated


           Gastrointestinal
10065722   disorders          Anal necrosis      -

           Gastrointestinal
10002167   disorders          Anal pain          Mild pain




                                                 Asymptomatic; clinical or
           Gastrointestinal                      diagnostic observations only;
10002176   disorders          Anal stenosis      intervention not indicated


                                                 Asymptomatic; clinical or
           Gastrointestinal                      diagnostic observations only;
10002180   disorders          Anal ulcer         intervention not indicated

                                                 Asymptomatic; clinical or
           Gastrointestinal                      diagnostic observations only;
10003445   disorders          Ascites            intervention not indicated


           Gastrointestinal                      No change in bowel function
10005265   disorders          Bloating           or oral intake




           Gastrointestinal                      Mild; intervention not
10065747   disorders          Cecal hemorrhage   indicated

                                                 Asymptomatic; clinical or
           Gastrointestinal                      diagnostic observations only;
10008417   disorders          Cheilitis          intervention not indicated

                                                 Asymptomatic; clinical or
           Gastrointestinal                      diagnostic observations only;
10009887   disorders          Colitis            intervention not indicated
                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10009995   disorders          Colonic fistula       intervention not indicated




           Gastrointestinal                         Mild; intervention not
10009998   disorders          Colonic hemorrhage    indicated

                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10010000   disorders          Colonic obstruction   intervention not indicated

           Gastrointestinal
10010001   disorders          Colonic perforation


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10010004   disorders          Colonic stenosis      intervention not indicated


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10010006   disorders          Colonic ulcer         intervention not indicated

                                                    Occasional or intermittent
                                                    symptoms; occasional use of
                                                    stool softeners, laxatives,
           Gastrointestinal                         dietary modification, or
10010774   disorders          Constipation          enema


           Gastrointestinal                         One or more dental caries,
10012318   disorders          Dental caries         not involving the root




                                                    Increase of <4 stools per day
                                                    over baseline; mild increase
           Gastrointestinal                         in ostomy output compared
10012727   disorders          Diarrhea              to baseline
                                                     Symptomatic (e.g., dry or
                                                     thick saliva) without
                                                     significant dietary alteration;
           Gastrointestinal                          unstimulated saliva flow >0.2
10013781   disorders          Dry mouth              ml/min




                                                     Asymptomatic; clinical or
           Gastrointestinal                          diagnostic observations only;
10013828   disorders          Duodenal fistula       intervention not indicated




           Gastrointestinal                          Mild; intervention not
10055242   disorders          Duodenal hemorrhage    indicated

                                                     Asymptomatic; clinical or
           Gastrointestinal                          diagnostic observations only;
10013830   disorders          Duodenal obstruction   intervention not indicated


           Gastrointestinal
10013832   disorders          Duodenal perforation   -


                                                     Asymptomatic; clinical or
           Gastrointestinal                          diagnostic observations only;
10050094   disorders          Duodenal stenosis      intervention not indicated




                                                     Asymptomatic; clinical or
           Gastrointestinal                          diagnostic observations only;
10013836   disorders          Duodenal ulcer         intervention not indicated

           Gastrointestinal                          Mild symptoms; intervention
10013946   disorders          Dyspepsia              not indicated


           Gastrointestinal                          Symptomatic, able to eat
10013950   disorders          Dysphagia              regular diet
                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10014893   disorders          Enterocolitis            intervention not indicated

                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10062570   disorders          Enterovesical fistula    intervention not indicated




                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10065851   disorders          Esophageal fistula       intervention not indicated




           Gastrointestinal                         Mild; intervention not
10015384   disorders          Esophageal hemorrhage indicated




           Gastrointestinal
10065727   disorders          Esophageal necrosis      -


                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10015387   disorders          Esophageal obstruction   intervention not indicated

           Gastrointestinal
10015388   disorders          Esophageal pain          Mild pain


           Gastrointestinal
10055472   disorders          Esophageal perforation   -


                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10015448   disorders          Esophageal stenosis      intervention not indicated




                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10015451   disorders          Esophageal ulcer         intervention not indicated
           Gastrointestinal   Esophageal varices
10015453   disorders          hemorrhage

                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10015461   disorders          Esophagitis           intervention not indicated

           Gastrointestinal                         Occasional use of pads
10016296   disorders          Fecal incontinence    required


           Gastrointestinal                         Mild symptoms; intervention
10016766   disorders          Flatulence            not indicated




                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10065713   disorders          Gastric fistula       intervention not indicated




           Gastrointestinal                         Mild; intervention not
10017789   disorders          Gastric hemorrhage    indicated




           Gastrointestinal
10051886   disorders          Gastric necrosis      -


           Gastrointestinal
10017815   disorders          Gastric perforation   -


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10061970   disorders          Gastric stenosis      intervention not indicated




                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10017822   disorders          Gastric ulcer         intervention not indicated
                                                         Asymptomatic; clinical or
           Gastrointestinal                              diagnostic observations only;
10017853   disorders          Gastritis                  intervention not indicated



           Gastrointestinal   Gastroesophageal reflux Mild symptoms; intervention
10066874   disorders          disease                 not indicated

                                                         Asymptomatic; clinical or
           Gastrointestinal                              diagnostic observations only;
10017877   disorders          Gastrointestinal fistula   intervention not indicated

           Gastrointestinal
10017999   disorders          Gastrointestinal pain      Mild pain




                                                         Mild nausea, early satiety and
           Gastrointestinal                              bloating, able to maintain
10018043   disorders          Gastroparesis              caloric intake on regular diet

           Gastrointestinal
10018286   disorders          Gingival pain              Mild pain




           Gastrointestinal   Hemorrhoidal               Mild; intervention not
10060640   disorders          hemorrhage                 indicated

                                                         Asymptomatic; clinical or
           Gastrointestinal                              diagnostic observations only;
10019611   disorders          Hemorrhoids                intervention not indicated


                                                         Asymptomatic; clinical or
           Gastrointestinal                              diagnostic observations only;
10065728   disorders          Ileal fistula              intervention not indicated




           Gastrointestinal                              Mild; intervention not
10055287   disorders          Ileal hemorrhage           indicated
                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10065730   disorders          Ileal obstruction     intervention not indicated


           Gastrointestinal
10021305   disorders          Ileal perforation     -


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10021307   disorders          Ileal stenosis        intervention not indicated


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10021309   disorders          Ileal ulcer           intervention not indicated

           Gastrointestinal
10021328   disorders          Ileus                 -


           Gastrointestinal   Intra-abdominal
10055291   disorders          hemorrhage            -


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10065719   disorders          Jejunal fistula       intervention not indicated




           Gastrointestinal                         Mild; intervention not
10055300   disorders          Jejunal hemorrhage    indicated


                                                    Asymptomatic; clinical or
           Gastrointestinal                         diagnostic observations only;
10065732   disorders          Jejunal obstruction   intervention not indicated


           Gastrointestinal
10023174   disorders          Jejunal perforation   -
                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10023176   disorders          Jejunal stenosis         intervention not indicated


                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10023177   disorders          Jejunal ulcer            intervention not indicated

           Gastrointestinal
10024561   disorders          Lip pain                 Mild pain




           Gastrointestinal   Lower gastrointestinal   Mild; intervention not
10051746   disorders          hemorrhage               indicated

           Gastrointestinal
10025476   disorders          Malabsorption            -

                                                       Asymptomatic or mild
           Gastrointestinal                            symptoms; intervention not
10028130   disorders          Mucositis oral           indicated




           Gastrointestinal                            Loss of appetite without
10028813   disorders          Nausea                   alteration in eating habits


                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10029957   disorders          Obstruction gastric      intervention not indicated


                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10065720   disorders          Oral cavity fistula      intervention not indicated

           Gastrointestinal                            Mild discomfort; not
10054520   disorders          Oral dysesthesia         interfering with oral intake
           Gastrointestinal                            Mild; intervention not
10030980   disorders          Oral hemorrhage          indicated

           Gastrointestinal
10031009   disorders          Oral pain                Mild pain


                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10065703   disorders          Pancreatic duct stenosis intervention not indicated




                                                       Asymptomatic; clinical or
           Gastrointestinal                            diagnostic observations only;
10049192   disorders          Pancreatic fistula       intervention not indicated




           Gastrointestinal                            Mild; intervention not
10033626   disorders          Pancreatic hemorrhage    indicated


           Gastrointestinal
10058096   disorders          Pancreatic necrosis       -


           Gastrointestinal
10033645   disorders          Pancreatitis              -




                                                       Gingival recession or
           Gastrointestinal                            gingivitis; limited bleeding on
10034536   disorders          Periodontal disease      probing; mild local bone loss


           Gastrointestinal
10065704   disorders          Peritoneal necrosis       -
           Gastrointestinal                        Rectal discomfort,
10036774   disorders          Proctitis            intervention not indicated


                                                   Asymptomatic; clinical or
           Gastrointestinal                        diagnostic observations only;
10038062   disorders          Rectal fistula       intervention not indicated




           Gastrointestinal                        Mild; intervention not
10038064   disorders          Rectal hemorrhage    indicated

                                                   Asymptomatic or mild
           Gastrointestinal                        symptoms; intervention not
10063190   disorders          Rectal mucositis     indicated


           Gastrointestinal
10065709   disorders          Rectal necrosis      -


                                                   Asymptomatic; clinical or
           Gastrointestinal                        diagnostic observations only;
10065707   disorders          Rectal obstruction   intervention not indicated

           Gastrointestinal
10038072   disorders          Rectal pain          Mild pain


           Gastrointestinal
10038073   disorders          Rectal perforation   -


                                                   Asymptomatic; clinical or
           Gastrointestinal                        diagnostic observations only;
10038079   disorders          Rectal stenosis      intervention not indicated


                                                   Asymptomatic; clinical or
           Gastrointestinal                        diagnostic observations only;
10038080   disorders          Rectal ulcer         intervention not indicated
           Gastrointestinal   Retroperitoneal
10038981   disorders          hemorrhage                  -




                                                          Slightly thickened saliva;
           Gastrointestinal   Salivary duct               slightly altered taste (e.g.,
10056681   disorders          inflammation                metallic)


                                                          Asymptomatic; clinical or
           Gastrointestinal                               diagnostic observations only;
10039411   disorders          Salivary gland fistula      intervention not indicated


                                                         Asymptomatic or mild
           Gastrointestinal                              symptoms; intervention not
10065710   disorders          Small intestinal mucositis indicated


                                                          Asymptomatic; clinical or
           Gastrointestinal   Small intestinal            diagnostic observations only;
10041101   disorders          obstruction                 intervention not indicated


           Gastrointestinal   Small intestinal
10041103   disorders          perforation                 -




                                                          Asymptomatic; clinical or
           Gastrointestinal                               diagnostic observations only;
10062263   disorders          Small intestinal stenosis   intervention not indicated




                                                          Asymptomatic; clinical or
           Gastrointestinal                               diagnostic observations only;
10041133   disorders          Small intestine ulcer       intervention not indicated

           Gastrointestinal
10042112   disorders          Stomach pain                Mild pain
           Gastrointestinal        Tooth development         Asymptomatic; hypoplasia of
10044030   disorders               disorder                  tooth or enamel
           Gastrointestinal
10044031   disorders               Tooth discoloration       Surface stains

           Gastrointestinal
10044055   disorders               Toothache                 Mild pain




           Gastrointestinal
10045271   disorders               Typhlitis                  -




           Gastrointestinal        Upper gastrointestinal    Mild; intervention not
10055356   disorders               hemorrhage                indicated


           Gastrointestinal                                  1 - 2 episodes (separated by 5
10047700   disorders               Vomiting                  minutes) in 24 hrs




                                                              Asymptomatic or mild
                                                              symptoms; clinical or
           Gastrointestinal        Gastrointestinal           diagnostic observations only;
10017947   disorders               disorders - Other, specify intervention not indicated
           General disorders and
           administration site                               Mild sensation of cold;
10008531   conditions              Chills                    shivering; chattering of teeth
           General disorders and
           administration site
10011912   conditions              Death neonatal             -
           General disorders and
           administration site
10011914   conditions              Death NOS                  -
           General disorders and
           administration site
10014222   conditions              Edema face                Localized facial edema
                                                       5 - 10% inter-limb
                                                       discrepancy in volume or
                                                       circumference at point of
                                                       greatest visible difference;
           General disorders and                       swelling or obscuration of
           administration site                         anatomic architecture on
10050068   conditions              Edema limbs         close inspection




           General disorders and                       Swelling or obscuration of
           administration site                         anatomic architecture on
10058720   conditions              Edema trunk         close inspection
           General disorders and
           administration site
10016059   conditions              Facial pain         Mild pain
           General disorders and
           administration site
10016256   conditions              Fatigue             Fatigue relieved by rest
           General disorders and
           administration site                         38.0 - 39.0 degrees C (100.4 -
10016558   conditions              Fever               102.2 degrees F)
           General disorders and
           administration site                         Mild flu-like symptoms
10016791   conditions              Flu like symptoms   present




           General disorders and
           administration site                         Mild change in gait (e.g., wide-
10017577   conditions              Gait disturbance    based, limping or hobbling)
           General disorders and
           administration site
10021113   conditions              Hypothermia               -




                                                             Mild transient reaction;
           General disorders and                             infusion interruption not
           administration site                               indicated; intervention not
10051792   conditions              Infusion related reaction indicated

           General disorders and
           administration site     Infusion site
10064774   conditions              extravasation

           General disorders and                             Tenderness with or without
           administration site                               associated symptoms (e.g.,
10022095   conditions              Injection site reaction   warmth, erythema, itching)

           General disorders and
           administration site
10022998   conditions              Irritability              Mild; easily consolable


           General disorders and                             Localized to dependent
           administration site                               areas, no disability or
10062466   conditions              Localized edema           functional impairment
           General disorders and
           administration site                               Uneasiness or lack of well
10025482   conditions              Malaise                   being




           General disorders and
           administration site
10028154   conditions              Multi-organ failure       -
           General disorders and
           administration site                               Asymptomatic localized neck
10054482   conditions               Neck edema               edema
           General disorders and
           administration site
10062501   conditions               Non-cardiac chest pain   Mild pain
           General disorders and
           administration site
10033371   conditions               Pain                     Mild pain
           General disorders and
           administration site
10042435   conditions               Sudden death NOS         -




                                    General disorders and    Asymptomatic or mild
           General disorders and    administration site      symptoms; clinical or
           administration site      conditions - Other,      diagnostic observations only;
10018065   conditions               specify                  intervention not indicated


                                                             Asymptomatic; clinical or
                                                             diagnostic observations only;
10051341   Hepatobiliary disorders Bile duct stenosis        intervention not indicated




10004665   Hepatobiliary disorders Biliary fistula           -




10008612   Hepatobiliary disorders Cholecystitis             -




                                                             Asymptomatic clinical or
                                                             diagnostic observations only;
10017631   Hepatobiliary disorders Gallbladder fistula       intervention not indicated
10059446   Hepatobiliary disorders Gallbladder necrosis      -




                                                             Asymptomatic; clinical or
                                                             diagnostic observations only;
10017636   Hepatobiliary disorders Gallbladder obstruction   intervention not indicated


10017638   Hepatobiliary disorders Gallbladder pain          Mild pain


10017639   Hepatobiliary disorders Gallbladder perforation   -




10019663   Hepatobiliary disorders Hepatic failure           -

                                                             Mild; intervention not
10019678   Hepatobiliary disorders Hepatic hemorrhage        indicated




10019692   Hepatobiliary disorders Hepatic necrosis          -


10019705   Hepatobiliary disorders Hepatic pain              Mild pain




10034405   Hepatobiliary disorders Perforation bile duct     -


10036200   Hepatobiliary disorders Portal hypertension       -


10036206   Hepatobiliary disorders Portal vein thrombosis    -
                                                             Asymptomatic or mild
                                                             symptoms; clinical or
                                   Hepatobiliary disorders - diagnostic observations only;
10019805   Hepatobiliary disorders Other, specify            intervention not indicated




                                                             Transient flushing or rash,
                                                             drug fever <38 degrees C
           Immune system                                     (<100.4 degrees F);
10001718   disorders               Allergic reaction         intervention not indicated




           Immune system
10002218   disorders               Anaphylaxis                -

                                                             Asymptomatic; serologic or
                                                             other evidence of
                                                             autoimmune reaction, with
           Immune system                                     normal organ function;
10061664   disorders               Autoimmune disorder       intervention not indicated




                                                             Mild reaction; infusion
           Immune system           Cytokine release          interruption not indicated;
10052015   disorders               syndrome                  intervention not indicated
                                                      Asymptomatic; clinical or
           Immune system                              diagnostic observations only;
10040400   disorders        Serum sickness            intervention not indicated




                                                       Asymptomatic or mild
                                                       symptoms; clinical or
           Immune system    Immune system              diagnostic observations only;
10021428   disorders        disorders - Other, specify intervention not indicated




           Infections and
10056519   infestations     Abdominal infection        -




           Infections and                             Localized; local intervention
10061640   infestations     Anorectal infection       indicated




           Infections and
10003011   infestations     Appendicitis               -



           Infections and
10003012   infestations     Appendicitis perforated    -




           Infections and
10065744   infestations     Arteritis infective        -




           Infections and
10061695   infestations     Biliary tract infection    -
           Infections and
10005047   infestations     Bladder infection          -




           Infections and
10061017   infestations     Bone infection             -




           Infections and
10006259   infestations     Breast infection           -




           Infections and
10055078   infestations     Bronchial infection        -




           Infections and   Catheter related
10007810   infestations     infection                  -




           Infections and
10065761   infestations     Cecal infection            -




           Infections and
10008330   infestations     Cervicitis infection       -




           Infections and
10010742   infestations     Conjunctivitis infective   -
           Infections and
10061788   infestations     Corneal infection          -




           Infections and
10065765   infestations     Cranial nerve infection    -




           Infections and
10064687   infestations     Device related infection   -




           Infections and
10065752   infestations     Duodenal infection         -




           Infections and
10014594   infestations     Encephalitis infection     -




           Infections and   Encephalomyelitis
10014621   infestations     infection                  -




           Infections and
10014678   infestations     Endocarditis infective     -
           Infections and
10014801   infestations     Endophthalmitis            -
           Infections and
10058838   infestations     Enterocolitis infectious   -




           Infections and
10058804   infestations     Esophageal infection       -




           Infections and
10015929   infestations     Eye infection              -




           Infections and
10062632   infestations     Gallbladder infection      -




           Infections and                              Local therapy indicated
10018784   infestations     Gum infection              (swish and swallow)




           Infections and
10056522   infestations     Hepatic infection          -




           Infections and                              Asymptomatic, treatment not
10019799   infestations     Hepatitis viral            indicated




           Infections and
10021918   infestations     Infective myositis         -
           Infections and
10023216   infestations     Joint infection         -




           Infections and
10023424   infestations     Kidney infection        -




           Infections and
10023874   infestations     Laryngitis              -




           Infections and                           Localized, local intervention
10065755   infestations     Lip infection           indicated




           Infections and
10061229   infestations     Lung infection          -




           Infections and
10050823   infestations     Lymph gland infection   -




           Infections and
10057483   infestations     Mediastinal infection   -




           Infections and
10027199   infestations     Meningitis              -
           Infections and                         Localized, local intervention
10065764   infestations     Mucosal infection     indicated




           Infections and                         Localized, local intervention
10061304   infestations     Nail infection        indicated




           Infections and
10033072   infestations     Otitis externa        -




           Infections and
10033078   infestations     Otitis media          -




           Infections and
10055005   infestations     Ovarian infection     -




           Infections and
10051741   infestations     Pancreas infection    -




                                                  Papules and/or pustules
                                                  covering <10% BSA, which
                                                  may or may not be
           Infections and                         associated with symptoms of
10069138   infestations     Papulopustular rash   pruritus or tenderness
           Infections and                           Nail fold edema or erythema;
10034016   infestations     Paronychia              disruption of the cuticle




           Infections and
10058674   infestations     Pelvic infection        -




           Infections and
10061912   infestations     Penile infection        -




           Infections and
10051472   infestations     Periorbital infection   -




           Infections and   Peripheral nerve
10065766   infestations     infection               -




           Infections and
10057262   infestations     Peritoneal infection    -




           Infections and
10034835   infestations     Pharyngitis             -
           Infections and
10056627   infestations     Phlebitis infective        -




           Infections and
10061351   infestations     Pleural infection          -




           Infections and
10050662   infestations     Prostate infection         -




           Infections and
10037888   infestations     Rash pustular              -




           Infections and
10059827   infestations     Rhinitis infective         -




           Infections and
10039413   infestations     Salivary gland infection   -




           Infections and
10062156   infestations     Scrotal infection          -

           Infections and
10040047   infestations     Sepsis                     -
           Infections and
10040753   infestations     Sinusitis                   -




           Infections and                               Localized, local intervention
10040872   infestations     Skin infection              indicated




           Infections and
10065771   infestations     Small intestine infection   -




           Infections and
10062255   infestations     Soft tissue infection       -




           Infections and
10062112   infestations     Splenic infection           -




           Infections and                               Localized, local intervention
10064505   infestations     Stoma site infection        indicated




           Infections and
10048762   infestations     Tooth infection             -




           Infections and
10044302   infestations     Tracheitis                  -
           Infections and   Upper respiratory
10046300   infestations     infection                 -




           Infections and
10052298   infestations     Urethral infection        -




           Infections and
10046571   infestations     Urinary tract infection   -




           Infections and
10062233   infestations     Uterine infection         -




           Infections and
10046914   infestations     Vaginal infection         -




           Infections and                             Localized, local intervention
10065772   infestations     Vulval infection          indicated




           Infections and
10048038   infestations     Wound infection           -
                                                              Asymptomatic or mild
                                   Infections and             symptoms; clinical or
           Infections and          infestations - Other,      diagnostic observations only;
10021881   infestations            specify                    intervention not indicated

           Injury, poisoning and
           procedural                                         Mild; non-surgical
10002544   complications           Ankle fracture             intervention indicated




           Injury, poisoning and
           procedural
10002899   complications           Aortic injury              -




           Injury, poisoning and                              Asymptomatic diagnostic
           procedural                                         finding; intervention not
10003162   complications           Arterial injury            indicated

           Injury, poisoning and                              Asymptomatic diagnostic
           procedural                                         observations only;
10050458   complications           Biliary anastomotic leak   intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10065802   complications           Bladder anastomotic leak intervention not indicated
           Injury, poisoning and
           procedural                                         Localized or in a dependent
10006504   complications           Bruising                   area

           Injury, poisoning and
           procedural                                         Minimal symptoms;
10006634   complications           Burn                       intervention not indicated




           Injury, poisoning and
           procedural                                         Faint erythema or dry
10061103   complications           Dermatitis radiation       desquamation
           Injury, poisoning and                          Asymptomatic diagnostic
           procedural              Esophageal anastomotic observations only;
10065961   complications           leak                   intervention not indicated

           Injury, poisoning and                              Minor with no resultant
           procedural                                         injuries; intervention not
10016173   complications           Fall                       indicated

           Injury, poisoning and                              Asymptomatic; clinical or
           procedural              Fallopian tube             diagnostic observations only;
10065788   complications           anastomotic leak           intervention not indicated


           Injury, poisoning and                              Asymptomatic diagnostic
           procedural              Fallopian tube             observations only;
10065790   complications           perforation                intervention not indicated


           Injury, poisoning and                              Asymptomatic; clinical or
           procedural                                         diagnostic observations only;
10017076   complications           Fracture                   intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10065893   complications           Gastric anastomotic leak intervention not indicated

           Injury, poisoning and                              Asymptomatic diagnostic
           procedural              Gastrointestinal           observations only;
10065879   complications           anastomotic leak           intervention not indicated

           Injury, poisoning and
           procedural              Gastrointestinal stoma
10065712   complications           necrosis                   -




           Injury, poisoning and
           procedural
10020100   complications           Hip fracture               -


           Injury, poisoning and
           procedural
10022161   complications           Injury to carotid artery   -
           Injury, poisoning and
           procedural              Injury to inferior vena
10022213   complications           cava                      -
           Injury, poisoning and
           procedural
10065849   complications           Injury to jugular vein    -




           Injury, poisoning and                             Asymptomatic diagnostic
           procedural              Injury to superior vena   finding; intervention not
10022356   complications           cava                      indicated

           Injury, poisoning and                             Asymptomatic diagnostic
           procedural                                        observations only;
10059095   complications           Intestinal stoma leak     intervention not indicated


           Injury, poisoning and
           procedural              Intestinal stoma
10059094   complications           obstruction

           Injury, poisoning and                             Minimal bleeding identified
           procedural              Intestinal stoma site     on clinical exam; intervention
10049468   complications           bleeding                  not indicated

           Injury, poisoning and
           procedural              Intraoperative arterial   Primary repair of injured
10065826   complications           injury                    organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative breast     Primary repair of injured
10065831   complications           injury                    organ/structure indicated
           Injury, poisoning and
           procedural              Intraoperative cardiac
10065843   complications           injury                    -


           Injury, poisoning and
           procedural                                        Primary repair of injured
10065844   complications           Intraoperative ear injury organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative endocrine Primary repair of injured
10065834   complications           injury                   organ/structure indicated
           Injury, poisoning and
           procedural              Intraoperative            Primary repair of injured
10065825   complications           gastrointestinal injury   organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative head and Primary repair of injured
10065842   complications           neck injury             organ/structure indicated
           Injury, poisoning and
           procedural              Intraoperative
10055298   complications           hemorrhage                -

           Injury, poisoning and
           procedural              Intraoperative            Primary repair of injured
10065827   complications           hepatobiliary injury      organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative            Primary repair of injured
10065829   complications           musculoskeletal injury    organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative            Primary repair of injured
10065830   complications           neurological injury       organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative ocular     Primary repair of injured
10065841   complications           injury                    organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative renal      Primary repair of injured
10065845   complications           injury                    organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative            Primary repair of injured
10065840   complications           reproductive tract injury organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative            Primary repair of injured
10065832   complications           respiratory injury        organ/structure indicated

           Injury, poisoning and
           procedural                                         Primary repair of injured
10065846   complications           Intraoperative skin injury organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative splenic
10065847   complications           injury                    -
           Injury, poisoning and
           procedural              Intraoperative urinary   Primary repair of injured
10065828   complications           injury                   organ/structure indicated

           Injury, poisoning and
           procedural              Intraoperative venous    Primary repair of injured
10065848   complications           injury                   organ/structure indicated

           Injury, poisoning and                           Asymptomatic diagnostic
           procedural                                      observations only;
10065803   complications           Kidney anastomotic leak intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural              Large intestinal         observations only;
10065891   complications           anastomotic leak         intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural              Pancreatic anastomotic   observations only;
10050457   complications           leak                     intervention not indicated

           Injury, poisoning and                          Asymptomatic diagnostic
           procedural              Pharyngeal anastomotic observations only;
10065705   complications           leak                   intervention not indicated




           Injury, poisoning and                            Minimal bleeding identified
           procedural              Postoperative            on clinical exam; intervention
10055322   complications           hemorrhage               not indicated


           Injury, poisoning and
           procedural              Postoperative thoracic
10056745   complications           procedure complication   -




           Injury, poisoning and
           procedural              Prolapse of intestinal
10065745   complications           stoma                    Asymptomatic; reducible

           Injury, poisoning and                            Asymptomatic; clinical or
           procedural                                       diagnostic observations only;
10065822   complications           Prolapse of urostomy     intervention not indicated
           Injury, poisoning and
           procedural              Radiation recall reaction Faint erythema or dry
10037767   complications           (dermatologic)            desquamation

           Injury, poisoning and                             Asymptomatic diagnostic
           procedural                                        observations only;
10065894   complications           Rectal anastomotic leak   intervention not indicated

           Injury, poisoning and                             Asymptomatic; clinical or
           procedural                                        diagnostic observations only;
10040102   complications           Seroma                    intervention not indicated

           Injury, poisoning and                             Asymptomatic diagnostic
           procedural              Small intestinal          observations only;
10065892   complications           anastomotic leak          intervention not indicated

           Injury, poisoning and                             Asymptomatic diagnostic
           procedural              Spermatic cord            observations only;
10065897   complications           anastomotic leak          intervention not indicated




           Injury, poisoning and                             Mild back pain;
           procedural                                        nonprescription analgesics
10041569   complications           Spinal fracture           indicated




           Injury, poisoning and
           procedural              Stenosis of
10065898   complications           gastrointestinal stoma    -

           Injury, poisoning and                             Asymptomatic; clinical or
           procedural                                        diagnostic observations only;
10042127   complications           Stomal ulcer              intervention not indicated

                                                             Minimal bleeding identified
           Injury, poisoning and                             on clinical or diagnostic
           procedural                                        exam; intervention not
10062548   complications           Tracheal hemorrhage       indicated
                                                            Partial asymptomatic
           Injury, poisoning and                            obstruction on examination
           procedural                                       (e.g., visual, radiologic or
10044291   complications           Tracheal obstruction     endoscopic)

           Injury, poisoning and                            Minimal bleeding identified
           procedural              Tracheostomy site        on clinical exam; intervention
10065749   complications           bleeding                 not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural              Ureteric anastomotic     observations only;
10065814   complications           leak                     intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural              Urethral anastomotic     observations only;
10065815   complications           leak                     intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10065882   complications           Urostomy leak            intervention not indicated




           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10065883   complications           Urostomy obstruction     intervention not indicated

           Injury, poisoning and                            Minimal bleeding identified
           procedural                                       on clinical exam; intervention
10065748   complications           Urostomy site bleeding   not indicated




           Injury, poisoning and
           procedural
10065885   complications           Urostomy stenosis         -

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10065886   complications           Uterine anastomotic leak intervention not indicated
           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10046810   complications           Uterine perforation      intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       observations only;
10065887   complications           Vaginal anastomotic leak intervention not indicated

           Injury, poisoning and                            Asymptomatic diagnostic
           procedural              Vas deferens             observations only;
10065888   complications           anastomotic leak         intervention not indicated




           Injury, poisoning and
           procedural              Vascular access
10062169   complications           complication              -




           Injury, poisoning and                            Asymptomatic diagnostic
           procedural                                       finding; intervention not
10047228   complications           Venous injury            indicated




           Injury, poisoning and                            Incisional separation of
           procedural                                       <=25% of wound, no deeper
10053692   complications           Wound complication       than superficial fascia




           Injury, poisoning and                            Incisional separation of
           procedural                                       <=25% of wound, no deeper
10048031   complications           Wound dehiscence         than superficial fascia

           Injury, poisoning and
           procedural                                       Mild; non-surgical
10048049   complications           Wrist fracture           intervention indicated
                                                            Asymptomatic or mild
           Injury, poisoning and   Injury, poisoning and    symptoms; clinical or
           procedural              procedural complications diagnostic observations only;
10022117   complications           - Other, specify         intervention not indicated



                                   Activated partial
                                   thromboplastin time
10000636   Investigations          prolonged                >1 - 1.5 x ULN




                                   Alanine
                                   aminotransferase
10001551   Investigations          increased                >ULN - 3.0 x ULN
                                   Alkaline phosphatase
10001675   Investigations          increased                >ULN - 2.5 x ULN




                                   Aspartate
                                   aminotransferase
10003481   Investigations          increased                >ULN - 3.0 x ULN

                                                            Asymptomatic; clinical or
                                   Blood antidiuretic       diagnostic observations only;
10005332   Investigations          hormone abnormal         intervention not indicated

10005364   Investigations          Blood bilirubin increased >ULN - 1.5 x ULN

                                                            Asymptomatic; clinical or
                                   Blood corticotrophin     diagnostic observations only;
10005452   Investigations          decreased                intervention not indicated
                                                     Asymptomatic; clinical or
                            Blood gonadotrophin      diagnostic observations only;
10005561   Investigations   abnormal                 intervention not indicated

                                                     Asymptomatic; clinical or
                                                     diagnostic observations only;
10005778   Investigations   Blood prolactin abnormal intervention not indicated




                                                     3 - 5 units below LLN; for
                            Carbon monoxide          follow-up, a decrease of 3 - 5
                            diffusing capacity       units (ml/sec/mm Hg) below
10065906   Investigations   decreased                the baseline value
                                                     Levels above the upper limit
                                                     of normal and below the
                                                     level of myocardial infarction
                            Cardiac troponin I       as defined by the
10007612   Investigations   increased                manufacturer
                                                     Levels above the upper limit
                                                     of normal and below the
                                                     level of myocardial infarction
                            Cardiac troponin T       as defined by the
10007613   Investigations   increased                manufacturer
                            CD4 lymphocytes          <LLN - 500/mm3; <LLN - 0.5
10007839   Investigations   decreased                x 10e9 /L
                                                     >ULN - 300 mg/dL; >ULN -
10008661   Investigations   Cholesterol high         7.75 mmol/L

10011268   Investigations   CPK increased            >ULN - 2.5 x ULN
                                                     >1 - 1.5 x baseline; >ULN - 1.5
10011368   Investigations   Creatinine increased     x ULN


                            Ejection fraction
10050528   Investigations   decreased                 -




                            Electrocardiogram QT
                            corrected interval
10014383   Investigations   prolonged                QTc 450 - 480 ms
                                                    <1.0 - 0.75 x LLN or <25%
10016596   Investigations   Fibrinogen decreased    decrease from baseline

                                                    FEV1% (percentages of
                                                    observed FEV1 and FVC
                                                    related to their respective
                            Forced expiratory       predicted values) 99 - 70%
10016987   Investigations   volume decreased        predicted




10056910   Investigations   GGT increased           >ULN - 2.5 x ULN

                                                    Asymptomatic; clinical or
                            Growth hormone          diagnostic observations only;
10018748   Investigations   abnormal                intervention not indicated

10019150   Investigations   Haptoglobin decreased   <LLN


                                                    Increase in >0 - 2 gm/dL
                                                    above ULN or above baseline
10055599   Investigations   Hemoglobin increased    if baseline is above ULN

                                                    >1 - 1.5 x ULN; >1 - 1.5 times
                                                    above baseline if on
10022402   Investigations   INR increased           anticoagulation

10024574   Investigations   Lipase increased        >ULN - 1.5 x ULN
                            Lymphocyte count        <LLN - 800/mm3; <LLN x 0.8 -
10025256   Investigations   decreased               10e9 /L

                            Lymphocyte count
10025258   Investigations   increased
                            Neutrophil count        <LLN - 1500/mm3; <LLN - 1.5
10029366   Investigations   decreased               x 10e9 /L

                            Pancreatic enzymes
10062646   Investigations   decreased               <LLN and asymptomatic

                                                     <LLN - 75,000/mm3; <LLN -
10035528   Investigations   Platelet count decreased 75.0 x 10e9 /L

10040139   Investigations   Serum amylase increased >ULN - 1.5 x ULN
10059895   Investigations        Urine output decreased    -




10047580   Investigations        Vital capacity abnormal   90 - 75% of predicted value


10047896   Investigations        Weight gain               5 - <10% from baseline

                                                           5 to <10% from baseline;
10047900   Investigations        Weight loss               intervention not indicated
                                 White blood cell          <LLN - 3000/mm3; <LLN - 3.0
10049182   Investigations        decreased                 x 10e9 /L




                                                           Asymptomatic or mild
                                                           symptoms; clinical or
                                 Investigations - Other,   diagnostic observations only;
10022891   Investigations        specify                   intervention not indicated
           Metabolism and
10000486   nutrition disorders   Acidosis                  pH <normal, but =>7.3

           Metabolism and
10001598   nutrition disorders   Alcohol intolerance       -
           Metabolism and
10001680   nutrition disorders   Alkalosis                 pH >normal, but <=7.5




           Metabolism and                                  Loss of appetite without
10002646   nutrition disorders   Anorexia                  alteration in eating habits
                                                           Increased oral fluids
                                                           indicated; dry mucous
           Metabolism and                                  membranes; diminished skin
10012174   nutrition disorders   Dehydration               turgor

                                                           Asymptomatic; clinical or
           Metabolism and                                  diagnostic observations only;
10052426   nutrition disorders   Glucose intolerance       intervention not indicated
                                                        >ULN - 11.5 mg/dL; >ULN -
           Metabolism and                               2.9 mmol/L; Ionized calcium
10020587   nutrition disorders   Hypercalcemia          >ULN - 1.5 mmol/L

                                                        Fasting glucose value >ULN -
           Metabolism and                               160 mg/dL; Fasting glucose
10020639   nutrition disorders   Hyperglycemia          value >ULN - 8.9 mmol/L

           Metabolism and
10020647   nutrition disorders   Hyperkalemia           >ULN - 5.5 mmol/L


           Metabolism and                               >ULN - 3.0 mg/dL; >ULN -
10020670   nutrition disorders   Hypermagnesemia        1.23 mmol/L

           Metabolism and
10020680   nutrition disorders   Hypernatremia          >ULN - 150 mmol/L


           Metabolism and                               150 mg/dL - 300 mg/dL; 1.71
10020870   nutrition disorders   Hypertriglyceridemia   mmol/L - 3.42 mmol/L

                                                        >ULN - 10 mg/dL; <=0.59
           Metabolism and                               mmol/L without physiologic
10020907   nutrition disorders   Hyperuricemia          consequences

           Metabolism and
10020943   nutrition disorders   Hypoalbuminemia        <LLN - 3 g/dL; <LLN - 30 g/L


                                                        <LLN - 8.0 mg/dL; <LLN - 2.0
           Metabolism and                               mmol/L; Ionized calcium
10020949   nutrition disorders   Hypocalcemia           <LLN - 1.0 mmol/L


           Metabolism and                               <LLN - 55 mg/dL; <LLN - 3.0
10021005   nutrition disorders   Hypoglycemia           mmol/L


           Metabolism and
10021018   nutrition disorders   Hypokalemia            <LLN - 3.0 mmol/L


           Metabolism and                               <LLN - 1.2 mg/dL; <LLN - 0.5
10021028   nutrition disorders   Hypomagnesemia         mmol/L
           Metabolism and
10021038   nutrition disorders   Hyponatremia            <LLN - 130 mmol/L


           Metabolism and                                <LLN - 2.5 mg/dL; <LLN - 0.8
10021059   nutrition disorders   Hypophosphatemia        mmol/L

           Metabolism and
10065973   nutrition disorders   Iron overload           -
           Metabolism and
10029883   nutrition disorders   Obesity                 -

           Metabolism and
10045152   nutrition disorders   Tumor lysis syndrome    -




                                                         Asymptomatic or mild
                                 Metabolism and          symptoms; clinical or
           Metabolism and        nutrition disorders -   diagnostic observations only;
10027433   nutrition disorders   Other, specify          intervention not indicated


           Musculoskeletal and
           connective tissue     Abdominal soft tissue
10065775   disorders             necrosis                -
           Musculoskeletal and
           connective tissue
10003239   disorders             Arthralgia              Mild pain




           Musculoskeletal and
           connective tissue                             Mild pain with inflammation,
10003246   disorders             Arthritis               erythema, or joint swelling

           Musculoskeletal and                           Asymptomatic; clinical or
           connective tissue                             diagnostic observations only;
10066480   disorders             Avascular necrosis      intervention not indicated
           Musculoskeletal and
           connective tissue
10003988   disorders             Back pain               Mild pain
           Musculoskeletal and
           connective tissue
10006002   disorders             Bone pain                   Mild pain
           Musculoskeletal and
           connective tissue
10048677   disorders             Buttock pain                Mild pain
           Musculoskeletal and
           connective tissue
10008496   disorders             Chest wall pain             Mild pain

           Musculoskeletal and                               Asymptomatic; clinical or
           connective tissue                                 diagnostic observations only;
10015688   disorders             Exostosis                   intervention not indicated


                                                          Mild induration, able to move
           Musculoskeletal and                            skin parallel to plane (sliding)
           connective tissue     Fibrosis deep connective and perpendicular to skin
10065799   disorders             tissue                   (pinching up)
           Musculoskeletal and
           connective tissue
10016750   disorders             Flank pain                  Mild pain


           Musculoskeletal and                               Symptomatic; weakness
           connective tissue     Generalized muscle          perceived by patient but not
10062572   disorders             weakness                    evident on physical exam




           Musculoskeletal and                               Reduction in growth velocity
           connective tissue                                 by 10 - 29% ideally measured
10018761   disorders             Growth suppression          over the period of a year




           Musculoskeletal and
           connective tissue
10065779   disorders             Head soft tissue necrosis

           Musculoskeletal and                               Asymptomatic; clinical or
           connective tissue                                 diagnostic observations only;
10023215   disorders             Joint effusion              intervention not indicated
           Musculoskeletal and                            <=25% loss of ROM (range of
           connective tissue     Joint range of motion    motion); decreased ROM
10048706   disorders             decreased                limiting athletic activity
           Musculoskeletal and                            Mild restriction of rotation or
           connective tissue     Joint range of motion    flexion between 60 - 70
10065796   disorders             decreased cervical spine degrees




                                                           Stiffness; difficulty bending to
           Musculoskeletal and                             the floor to pick up a very
           connective tissue     Joint range of motion     light object but able to do
10065800   disorders             decreased lumbar spine    athletic activity

           Musculoskeletal and                             Asymptomatic; clinical or
           connective tissue                               diagnostic observations only;
10023509   disorders             Kyphosis                  intervention not indicated

           Musculoskeletal and                             Asymptomatic; clinical or
           connective tissue                               diagnostic observations only;
10024842   disorders             Lordosis                  intervention not indicated

           Musculoskeletal and                             Symptomatic; perceived by
           connective tissue     Muscle weakness left-     patient but not evident on
10065780   disorders             sided                     physical exam

           Musculoskeletal and                             Symptomatic; perceived by
           connective tissue     Muscle weakness lower     patient but not evident on
10065776   disorders             limb                      physical exam

           Musculoskeletal and                             Symptomatic; perceived by
           connective tissue     Muscle weakness right-    patient but not evident on
10065794   disorders             sided                     physical exam

           Musculoskeletal and                             Symptomatic; perceived by
           connective tissue                               patient but not evident on
10065795   disorders             Muscle weakness trunk     physical exam

           Musculoskeletal and                         Symptomatic; perceived by
           connective tissue     Muscle weakness upper patient but not evident on
10065895   disorders             limb                  physical exam
           Musculoskeletal and
           connective tissue     Musculoskeletal            Cosmetically and functionally
10065783   disorders             deformity                  insignificant hypoplasia
           Musculoskeletal and
           connective tissue
10028411   disorders             Myalgia                    Mild pain


           Musculoskeletal and
           connective tissue
10028653   disorders             Myositis                   Mild pain
           Musculoskeletal and
           connective tissue
10028836   disorders             Neck pain                  Mild pain




           Musculoskeletal and
           connective tissue
10065781   disorders             Neck soft tissue necrosis -




           Musculoskeletal and                              Asymptomatic; clinical or
           connective tissue                                diagnostic observations only;
10064658   disorders             Osteonecrosis of jaw       intervention not indicated

                                                            Radiologic evidence of
                                                            osteoporosis or Bone Mineral
                                                            Density (BMD) t-score -1 to -
           Musculoskeletal and                              2.5 (osteopenia); no loss of
           connective tissue                                height or intervention
10031282   disorders             Osteoporosis               indicated
           Musculoskeletal and
           connective tissue
10033425   disorders             Pain in extremity          Mild pain




           Musculoskeletal and
           connective tissue
10065793   disorders             Pelvic soft tissue necrosis -
           Musculoskeletal and
           connective tissue                                   <20 degrees; clinically
10039722   disorders                 Scoliosis                 undetectable




           Musculoskeletal and
           connective tissue         Soft tissue necrosis lower
10065777   disorders                 limb                       -




           Musculoskeletal and
           connective tissue         Soft tissue necrosis
10065778   disorders                 upper limb                 -


                                                               Mild induration, able to move
           Musculoskeletal and                                 skin parallel to plane (sliding)
           connective tissue         Superficial soft tissue   and perpendicular to skin
10065798   disorders                 fibrosis                  (pinching up)
           Musculoskeletal and                                 Decreased ROM (range of
           connective tissue                                   motion) without impaired
10044684   disorders                 Trismus                   eating


           Musculoskeletal and
           connective tissue                                   Mild length discrepancy <2
10065738   disorders                 Unequal limb length       cm




                                                               Asymptomatic or mild
           Musculoskeletal and       Musculoskeletal and       symptoms; clinical or
           connective tissue         connective tissue         diagnostic observations only;
10028395   disorders                 disorder - Other, specify intervention not indicated
           Neoplasms benign,
           malignant and
           unspecified (incl cysts   Leukemia secondary to
10048293   and polyps)               oncology chemotherapy      -
           Neoplasms benign,
           malignant and
           unspecified (incl cysts   Myelodysplastic
10028533   and polyps)               syndrome                  -
           Neoplasms benign,
           malignant and
           unspecified (incl cysts   Treatment related
10049737   and polyps)               secondary malignancy      -
           Neoplasms benign,
           malignant and
           unspecified (incl cysts
10045158   and polyps)               Tumor pain                Mild pain




                                     Neoplasms benign,
           Neoplasms benign,         malignant and             Asymptomatic or mild
           malignant and             unspecified (incl cysts   symptoms; clinical or
           unspecified (incl cysts   and polyps) - Other,      diagnostic observations only;
10029104   and polyps)               specify                   intervention not indicated

                                                             Asymptomatic; clinical or
           Nervous system                                    diagnostic observations only;
10053662   disorders                 Abducens nerve disorder intervention not indicated

                                                              Asymptomatic; clinical or
           Nervous system                                     diagnostic observations only;
10060929   disorders                 Accessory nerve disorder intervention not indicated

                                                               Asymptomatic; clinical or
           Nervous system            Acoustic nerve disorder   diagnostic observations only;
10000521   disorders                 NOS                       intervention not indicated




           Nervous system                                      Mild restlessness or
10001540   disorders                 Akathisia                 increased motor activity

           Nervous system
10001949   disorders                 Amnesia                   Mild; transient memory loss
           Nervous system
10002953   disorders                 Aphonia                   -

           Nervous system
10003074   disorders                 Arachnoiditis             Mild symptoms
                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10003591   disorders        Ataxia                   intervention not indicated

                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10065417   disorders        Brachial plexopathy      intervention not indicated

                                                     Asymptomatic; clinical or
           Nervous system   Central nervous system   diagnostic observations only;
10065784   disorders        necrosis                 intervention not indicated




                                                     Post-craniotomy:
                                                     asymptomatic; Post-lumbar
                                                     puncture: transient
           Nervous system   Cerebrospinal fluid      headache; postural care
10008164   disorders        leakage                  indicated




                                                     Mild cognitive disability; not
                                                     interfering with
                                                     work/school/life
                                                     performance; specialized
           Nervous system                            educational services/devices
10009845   disorders        Cognitive disturbance    not indicated




           Nervous system   Concentration            Mild inattention or decreased
10010250   disorders        impairment               level of concentration


           Nervous system   Depressed level of
10012373   disorders        consciousness            Decreased level of alertness




           Nervous system                            Mild unsteadiness or
10013573   disorders        Dizziness                sensation of movement
           Nervous system
10013887   disorders        Dysarthria               Mild slurred speech

           Nervous system
10062872   disorders        Dysesthesia              Mild sensory alteration




           Nervous system                            Altered taste but no change
10013911   disorders        Dysgeusia                in diet


                                                     Awareness of receptive or
                                                     expressive characteristics;
           Nervous system                            not impairing ability to
10013951   disorders        Dysphasia                communicate

           Nervous system
10014217   disorders        Edema cerebral           -

           Nervous system
10014625   disorders        Encephalopathy           Mild symptoms


           Nervous system
10015832   disorders        Extrapyramidal disorder Mild involuntary movements

                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10051272   disorders        Facial muscle weakness   intervention not indicated

                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10061457   disorders        Facial nerve disorder    intervention not indicated

                                                   Asymptomatic; clinical or
           Nervous system   Glossopharyngeal nerve diagnostic observations only;
10061185   disorders        disorder               intervention not indicated

           Nervous system
10019211   disorders        Headache                 Mild pain
                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10020508   disorders        Hydrocephalus            intervention not indicated
           Nervous system
10020765   disorders        Hypersomnia              Mild increased need for sleep

                                                     Asymptomatic; clinical or
           Nervous system   Hypoglossal nerve        diagnostic observations only;
10061212   disorders        disorder                 intervention not indicated


                                                    Asymptomatic; clinical or
           Nervous system                           diagnostic observations only;
10022763   disorders        Intracranial hemorrhage intervention not indicated

                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10023030   disorders        Ischemia cerebrovascular intervention not indicated

                                                     Asymptomatic; clinical or
           Nervous system                            diagnostic observations only;
10065836   disorders        IVth nerve disorder      intervention not indicated

           Nervous system                            Mild symptoms; reduced
10024264   disorders        Lethargy                 alertness and awareness




                                                     Asymptomatic; small focal
                                                     T2/FLAIR hyperintensities;
                                                     involving periventricular
                                                     white matter or <1/3 of
                                                     susceptible areas of
                                                     cerebrum +/- mild increase in
           Nervous system                            subarachnoid space (SAS)
10024382   disorders        Leukoencephalopathy      and/or mild ventriculomegaly

           Nervous system
10027175   disorders        Memory impairment        Mild memory impairment

           Nervous system
10027198   disorders        Meningismus              Mild symptoms
           Nervous system
10028041   disorders        Movements involuntary Mild symptoms

                                                       Asymptomatic; mild signs
           Nervous system                              (e.g., Babinski's reflex or
10028524   disorders        Myelitis                   Lhermitte's sign)

           Nervous system
10029223   disorders        Neuralgia                  Mild pain

           Nervous system
10029864   disorders        Nystagmus                  -

                                                       Asymptomatic; clinical or
           Nervous system   Oculomotor nerve           diagnostic observations only;
10053661   disorders        disorder                   intervention not indicated

           Nervous system
10056388   disorders        Olfactory nerve disorder   -


           Nervous system
10033987   disorders        Paresthesia                Mild symptoms

                                                       Asymptomatic; clinical or
           Nervous system   Peripheral motor           diagnostic observations only;
10034580   disorders        neuropathy                 intervention not indicated
                                                       Asymptomatic; loss of deep
           Nervous system   Peripheral sensory         tendon reflexes or
10034620   disorders        neuropathy                 paresthesia

           Nervous system
10056238   disorders        Phantom pain               Mild pain
           Nervous system
10036653   disorders        Presyncope

                                                       Asymptomatic; clinical or
           Nervous system   Pyramidal tract            diagnostic observations only;
10063636   disorders        syndrome                   intervention not indicated




           Nervous system
10061928   disorders        Radiculitis                Mild symptoms
                                                   Asymptomatic; clinical or
           Nervous system   Recurrent laryngeal    diagnostic observations only;
10038130   disorders        nerve palsy            intervention not indicated


                            Reversible posterior   Asymptomatic; clinical or
           Nervous system   leukoencephalopathy    diagnostic observations only;
10063761   disorders        syndrome               intervention not indicated

           Nervous system                          Brief partial seizure; no loss
10039906   disorders        Seizure                of consciousness

           Nervous system
10040747   disorders        Sinus pain             Mild pain

           Nervous system                          Mild but more than usual
10041349   disorders        Somnolence             drowsiness or sleepiness




           Nervous system                          Mild or slight increase in
10041416   disorders        Spasticity             muscle tone
                                                   Asymptomatic or mild
           Nervous system                          neurologic deficit;
10042244   disorders        Stroke                 radiographic findings only
           Nervous system
10042772   disorders        Syncope                -

                                                   Mild neurologic deficit with
           Nervous system   Transient ischemic     or without imaging
10044391   disorders        attacks                confirmation

           Nervous system
10044565   disorders        Tremor                 Mild symptoms

                                                   Asymptomatic; clinical or
           Nervous system   Trigeminal nerve       diagnostic observations only;
10060890   disorders        disorder               intervention not indicated

                                                   Asymptomatic; clinical or
           Nervous system                          diagnostic observations only;
10061403   disorders        Vagus nerve disorder   intervention not indicated


           Nervous system
10047166   disorders        Vasovagal reaction     -
                                                              Asymptomatic or mild
                                                              symptoms; clinical or
           Nervous system          Nervous system             diagnostic observations only;
10029205   disorders               disorders - Other, specify intervention not indicated


           Pregnancy, puerperium
10016479   and perinatal conditions Fetal death               -

           Pregnancy, puerperium
10054746   and perinatal conditions Fetal growth retardation -

           Pregnancy, puerperium                             Delivery of a liveborn infant
10036595   and perinatal conditions Premature delivery       at >34 to 37 weeks gestation

           Pregnancy, puerperium
10045542   and perinatal conditions Unintended pregnancy      -




                                                            Asymptomatic or mild
                                    Pregnancy, puerperium symptoms; clinical or
           Pregnancy, puerperium and perinatal conditions - diagnostic observations only;
10036585   and perinatal conditions Other, specify          intervention not indicated


10001497   Psychiatric disorders   Agitation                 Mild mood alteration
                                                             Inability to achieve orgasm
                                                             not adversely affecting
10002652   Psychiatric disorders   Anorgasmia                relationship


                                                             Mild symptoms; intervention
10002855   Psychiatric disorders   Anxiety                   not indicated




10010300   Psychiatric disorders   Confusion                 Mild disorientation
                                                        Delay in achieving orgasm
                                                        not adversely affecting
10057066   Psychiatric disorders   Delayed orgasm       relationship




10012218   Psychiatric disorders   Delirium             Mild acute confusional state




10012260   Psychiatric disorders   Delusions            -




10012378   Psychiatric disorders   Depression           Mild depressive symptoms

10015533   Psychiatric disorders   Euphoria             Mild mood elevation




                                                        Mild hallucinations (e.g.,
10019077   Psychiatric disorders   Hallucinations       perceptual distortions)

                                                        Mild difficulty falling asleep,
                                                        staying asleep or waking up
10022437   Psychiatric disorders   Insomnia             early
                                                        Decrease in sexual interest
                                                        not adversely affecting
10024419   Psychiatric disorders   Libido decreased     relationship

                                                        Mild increase in sexual
                                                        interest not adversely
10024421   Psychiatric disorders   Libido increased     affecting relationship


                                                        Mild manic symptoms (e.g.,
                                                        elevated mood, rapid
                                                        thoughts, rapid speech,
10026749   Psychiatric disorders   Mania                decreased need for sleep)




10034719   Psychiatric disorders   Personality change   Mild personality change
10037234   Psychiatric disorders   Psychosis                 Mild psychotic symptoms

                                                             Mild symptoms; intervention
10038743   Psychiatric disorders   Restlessness              not indicated


                                                             Increased thoughts of death
10042458   Psychiatric disorders   Suicidal ideation         but no wish to kill oneself




10042464   Psychiatric disorders   Suicide attempt           -


                                                             Asymptomatic or mild
                                                             symptoms; clinical or
                                   Psychiatric disorders -   diagnostic observations only;
10037175   Psychiatric disorders   Other, specify            intervention not indicated
                                                             Creatinine level increase of
           Renal and urinary                                 >0.3 mg/dL; creatinine 1.5 -
10069339   disorders               Acute kidney injury       2.0 x above baseline




           Renal and urinary
10063575   disorders               Bladder perforation       -
           Renal and urinary
10048994   disorders               Bladder spasm             Intervention not indicated


                                                             eGFR (estimated Glomerular
                                                             Filtration Rate) or CrCl
                                                             (creatinine clearance) <LLN -
                                                             60 ml/min/1.73 m2 or
           Renal and urinary                                 proteinuria 2+ present; urine
10064848   disorders               Chronic kidney disease    protein/creatinine >0.5
                                                       Microscopic hematuria;
                                                       minimal increase in
                                                       frequency, urgency, dysuria,
           Renal and urinary                           or nocturia; new onset of
10063057   disorders           Cystitis noninfective   incontinence




                                                       Asymptomatic; clinical or
           Renal and urinary                           diagnostic observations only;
10019450   disorders           Hematuria               intervention not indicated

                                                       Asymptomatic; clinical or
           Renal and urinary                           diagnostic observations only;
10019489   disorders           Hemoglobinuria          intervention not indicated




           Renal and urinary                           1+ proteinuria; urinary
10037032   disorders           Proteinuria             protein <1.0 g/24 hrs




                                                       Asymptomatic or mild
                                                       symptoms; occasional use of
           Renal and urinary                           nonprescription analgesics
10038385   disorders           Renal calculi           indicated

                                                       Mild pain not interfering with
           Renal and urinary                           activity; nonprescription
10038419   disorders           Renal colic             medication indicated




           Renal and urinary                           Mild symptoms; intervention
10038463   disorders           Renal hemorrhage        not indicated
           Renal and urinary
10065368   disorders              Urinary fistula            -


           Renal and urinary
10046539   disorders              Urinary frequency         Present


                                                            Occasional (e.g., with
           Renal and urinary                                coughing, sneezing, etc.),
10046543   disorders              Urinary incontinence      pads not indicated

                                                            Urinary, suprapubic or
                                                            intermittent catheter
           Renal and urinary                                placement not indicated; able
10046555   disorders              Urinary retention         to void with some residual




           Renal and urinary                                Asymptomatic; clinical or
10061574   disorders              Urinary tract obstruction diagnostic observations only

           Renal and urinary
10062225   disorders              Urinary tract pain        Mild pain


           Renal and urinary
10046593   disorders              Urinary urgency           Present
           Renal and urinary
10046628   disorders              Urine discoloration       Present




                                                             Asymptomatic or mild
                                                             symptoms; clinical or
           Renal and urinary      Renal and urinary          diagnostic observations only;
10038359   disorders              disorders - Other, specify intervention not indicated
           Reproductive system
10003883   and breast disorders   Azoospermia                -
           Reproductive system                              Minimal asymmetry; minimal
10006179   and breast disorders   Breast atrophy            atrophy

           Reproductive system
10006298   and breast disorders   Breast pain               Mild pain

           Reproductive system                              Mild symptoms; intervention
10013934   and breast disorders   Dysmenorrhea              not indicated




                                                            Mild discomfort or pain
                                                            associated with vaginal
                                                            penetration; discomfort
           Reproductive system                              relieved with use of vaginal
10013941   and breast disorders   Dyspareunia               lubricants or estrogen

           Reproductive system
10014326   and breast disorders   Ejaculation disorder      Diminished ejaculation




                                                            Decrease in erectile function
                                                            (frequency or rigidity of
                                                            erections) but intervention
                                                            not indicated (e.g.,
                                                            medication or use of
           Reproductive system                              mechanical device, penile
10061461   and breast disorders   Erectile dysfunction      pump)

           Reproductive system    Fallopian tube            Diagnostic observations only;
10065789   and breast disorders   obstruction               intervention not indicated


                                                            Asymptomatic clinical or
           Reproductive system                              diagnostic observations only;
10065791   and breast disorders   Fallopian tube stenosis   intervention not indicated

                                                            Asymptomatic clinical or
           Reproductive system    Female genital tract      diagnostic observations only;
10061149   and breast disorders   fistula                   intervention not indicated

           Reproductive system                              Mild symptoms; intervention
10054382   and breast disorders   Feminization acquired     not indicated
                                                           Mild swelling or obscuration
           Reproductive system                             of anatomic architecture on
10018146   and breast disorders   Genital edema            close inspection

           Reproductive system                             Asymptomatic breast
10018801   and breast disorders   Gynecomastia             enlargement

                                                           Minimal bleeding identified
                                                           on imaging study or
           Reproductive system                             laparoscopy; intervention not
10060602   and breast disorders   Hematosalpinx            indicated

                                                           Intermittent menses with
           Reproductive system                             skipped menses for no more
10022992   and breast disorders   Irregular menstruation   than 1 to 3 months

                                                           Mild changes in lactation, not
                                                           significantly affecting
           Reproductive system                             production or expression of
10061261   and breast disorders   Lactation disorder       breast milk


           Reproductive system                             Mild; iron supplements
10027313   and breast disorders   Menorrhagia              indicated




                                                           Asymptomatic; asymmetry
                                                           with slight retraction and/or
           Reproductive system                             thickening of the nipple
10065823   and breast disorders   Nipple deformity         areolar complex

           Reproductive system                             Sperm concentration >48
10030300   and breast disorders   Oligospermia             million/mL or motility >68%

                                                           Minimal bleeding identified
                                                           on imaging study or
           Reproductive system                             laproscopy; intervention not
10065763   and breast disorders   Ovarian hemorrhage       indicated
                                                          Asymptomatic clinical or
           Reproductive system                            diagnostic observations only;
10033279   and breast disorders   Ovarian rupture         intervention not indicated

           Reproductive system
10033314   and breast disorders   Ovulation pain          Mild pain




                                                          Asymptomatic; clinical or
           Reproductive system    Pelvic floor muscle     diagnostic observations only;
10064026   and breast disorders   weakness                intervention not indicated

           Reproductive system
10034263   and breast disorders   Pelvic pain             Mild pain

           Reproductive system
10034310   and breast disorders   Penile pain             Mild pain

           Reproductive system
10061339   and breast disorders   Perineal pain           Mild pain

           Reproductive system
10036601   and breast disorders   Premature menopause

                                                          Minimal bleeding identified
           Reproductive system                            on imaging study;
10055325   and breast disorders   Prostatic hemorrhage    intervention not indicated


           Reproductive system                            Diagnostic observations only;
10055026   and breast disorders   Prostatic obstruction   intervention not indicated

           Reproductive system
10036968   and breast disorders   Prostatic pain          Mild pain

           Reproductive system
10039757   and breast disorders   Scrotal pain            Mild pain

                                                          Minimal bleeding identified
           Reproductive system    Spermatic cord          on imaging study;
10065762   and breast disorders   hemorrhage              intervention not indicated

           Reproductive system    Spermatic cord          Diagnostic observations only;
10065805   and breast disorders   obstruction             intervention not indicated
                                                          Asymptomatic; clinical or
           Reproductive system                            diagnostic observations only;
10043306   and breast disorders   Testicular disorder     intervention not indicated

                                                          Minimal bleeding identified
           Reproductive system                            on imaging study;
10055347   and breast disorders   Testicular hemorrhage   intervention not indicated

           Reproductive system
10043345   and breast disorders   Testicular pain         Mild pain

                                                          Asymptomatic clinical or
           Reproductive system                            diagnostic observations only;
10065811   and breast disorders   Uterine fistula         intervention not indicated

                                                          Minimal bleeding identified
           Reproductive system                            on imaging study;
10046789   and breast disorders   Uterine hemorrhage      intervention not indicated

           Reproductive system                            Diagnostic observations only;
10065928   and breast disorders   Uterine obstruction     intervention not indicated

           Reproductive system
10046809   and breast disorders   Uterine pain            Mild pain

                                                          Mild vaginal discharge
           Reproductive system                            (greater than baseline for
10046901   and breast disorders   Vaginal discharge       patient)


                                                          Mild vaginal dryness not
           Reproductive system                            interfering with sexual
10046904   and breast disorders   Vaginal dryness         function

                                                          Asymptomatic clinical or
           Reproductive system                            diagnostic observations only;
10065813   and breast disorders   Vaginal fistula         intervention not indicated

                                                          Minimal bleeding identified
                                                          on clinical exam or imaging
           Reproductive system                            study; intervention not
10046912   and breast disorders   Vaginal hemorrhage      indicated
           Reproductive system                               Mild discomfort or pain,
10046916   and breast disorders    Vaginal inflammation      edema, or redness

           Reproductive system                               Diagnostic observations only;
10065817   and breast disorders    Vaginal obstruction       intervention not indicated

           Reproductive system
10046937   and breast disorders    Vaginal pain              Mild pain

                                                             Asymptomatic clinical or
           Reproductive system                               diagnostic observations only;
10065818   and breast disorders    Vaginal perforation       intervention not indicated




           Reproductive system                               Asymptomatic; mild vaginal
10053496   and breast disorders    Vaginal stricture         shortening or narrowing


                                                             Mild discomfort or pain
                                                             associated with vaginal
                                                             spasm/tightening; no impact
           Reproductive system                               upon sexual function or
10046947   and breast disorders    Vaginismus                physical examination




                                                             Asymptomatic or mild
                                   Reproductive system and symptoms; clinical or
           Reproductive system     breast disorders - Other, diagnostic observations only;
10038604   and breast disorders    specify                   intervention not indicated


           Respiratory, thoracic
           and mediastinal         Adult respiratory distress
10001409   disorders               syndrome                   -


           Respiratory, thoracic
           and mediastinal                                   Mild symptoms; intervention
10001723   disorders               Allergic rhinitis         not indicated
           Respiratory, thoracic
           and mediastinal
10002972   disorders               Apnea                   -




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10003504   disorders               Aspiration              intervention not indicated




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10003598   disorders               Atelectasis             intervention not indicated




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10006437   disorders               Bronchial fistula       intervention not indicated




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10006440   disorders               Bronchial obstruction   intervention not indicated
           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10063524   disorders               Bronchial stricture      intervention not indicated




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10053481   disorders               Bronchopleural fistula   intervention not indicated




           Respiratory, thoracic
           and mediastinal         Bronchopulmonary         Mild symptoms; intervention
10065746   disorders               hemorrhage               not indicated




           Respiratory, thoracic
           and mediastinal                                  Mild symptoms; intervention
10006482   disorders               Bronchospasm             not indicated




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10051228   disorders               Chylothorax              intervention not indicated

           Respiratory, thoracic                            Mild symptoms;
           and mediastinal                                  nonprescription intervention
10011224   disorders               Cough                    indicated

           Respiratory, thoracic
           and mediastinal                                  Shortness of breath with
10013963   disorders               Dyspnea                  moderate exertion
           Respiratory, thoracic
           and mediastinal                                  Mild symptoms; intervention
10015090   disorders               Epistaxis                not indicated

           Respiratory, thoracic
           and mediastinal                                  Mild symptoms; intervention
10020039   disorders               Hiccups                  not indicated




           Respiratory, thoracic                            Mild or intermittent voice
           and mediastinal                                  change; fully understandable;
10020201   disorders               Hoarseness               self-resolves




           Respiratory, thoracic
           and mediastinal
10021143   disorders               Hypoxia                  -




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10023838   disorders               Laryngeal edema          intervention not indicated




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10065786   disorders               Laryngeal fistula        intervention not indicated


           Respiratory, thoracic                            Mild cough or trace
           and mediastinal                                  hemoptysis; laryngoscopic
10065759   disorders               Laryngeal hemorrhage     findings
           Respiratory, thoracic
           and mediastinal
10065735   disorders               Laryngeal inflammation   Mild sore throat; raspy voice
           Respiratory, thoracic                           Endoscopic findings only;
           and mediastinal                                 mild discomfort with normal
10065880   disorders               Laryngeal mucositis     intake




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10059639   disorders               Laryngeal obstruction   intervention not indicated




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10023862   disorders               Laryngeal stenosis      intervention not indicated




           Respiratory, thoracic
           and mediastinal         Laryngopharyngeal       Mild symptoms; no anxiety;
10062667   disorders               dysesthesia             intervention not indicated




           Respiratory, thoracic
           and mediastinal
10023891   disorders               Laryngospasm             -


           Respiratory, thoracic                          Radiologic evidence only;
           and mediastinal                                minimal symptoms;
10056356   disorders               Mediastinal hemorrhage intervention not indicated
           Respiratory, thoracic
           and mediastinal                                 Mild symptoms; intervention
10028735   disorders               Nasal congestion        not indicated
           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10034825   disorders               Pharyngeal fistula       intervention not indicated




           Respiratory, thoracic
           and mediastinal                               Mild symptoms; intervention
10055315   disorders               Pharyngeal hemorrhage not indicated

                                                            Endoscopic findings only;
           Respiratory, thoracic                            minimal symptoms with
           and mediastinal                                  normal oral intake; mild pain
10065881   disorders               Pharyngeal mucositis     but analgesics not indicated




           Respiratory, thoracic
           and mediastinal
10065706   disorders               Pharyngeal necrosis      -




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10050028   disorders               Pharyngeal stenosis      intervention not indicated
           Respiratory, thoracic
           and mediastinal
10034844   disorders               Pharyngolaryngeal pain   Mild pain




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10035598   disorders               Pleural effusion         intervention not indicated




           Respiratory, thoracic                            Asymptomatic; mild
           and mediastinal                                  hemorrhage confirmed by
10055319   disorders               Pleural hemorrhage       thoracentesis
           Respiratory, thoracic
           and mediastinal
10035623   disorders               Pleuritic pain          Mild pain




           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10035742   disorders               Pneumonitis             intervention not indicated


           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10035759   disorders               Pneumothorax            intervention not indicated
           Respiratory, thoracic
           and mediastinal                                 Mild symptoms; intervention
10036402   disorders               Postnasal drip          not indicated
           Respiratory, thoracic                           Occasional/minimal
           and mediastinal                                 production of sputum with
10036790   disorders               Productive cough        cough




           Respiratory, thoracic
           and mediastinal                                 Radiologic findings only;
10037375   disorders               Pulmonary edema         minimal dyspnea on exertion




           Respiratory, thoracic                           Mild hypoxemia; radiologic
           and mediastinal                                 pulmonary fibrosis <25% of
10037383   disorders               Pulmonary fibrosis      lung volume


           Respiratory, thoracic                           Asymptomatic; clinical or
           and mediastinal                                 diagnostic observations only;
10065873   disorders               Pulmonary fistula       intervention not indicated


           Respiratory, thoracic                          Minimal dyspnea; findings on
           and mediastinal                                physical exam or other
10037400   disorders               Pulmonary hypertension evaluation
           Respiratory, thoracic
           and mediastinal
10038695   disorders               Respiratory failure
                                                            Fluid retention; <3 kg of
           Respiratory, thoracic                            weight gain; intervention
           and mediastinal                                  with fluid restriction and/or
10038921   disorders               Retinoic acid syndrome   diuretics indicated




           Respiratory, thoracic                            Asymptomatic mucosal
           and mediastinal                                  crusting; blood-tinged
10062244   disorders               Sinus disorder           secretions




           Respiratory, thoracic                            Snoring and nocturnal sleep
           and mediastinal                                  arousal without apneic
10040975   disorders               Sleep apnea              periods
           Respiratory, thoracic
           and mediastinal                                  Mild symptoms; intervention
10041232   disorders               Sneezing                 not indicated
           Respiratory, thoracic
           and mediastinal
10041367   disorders               Sore throat              Mild pain


           Respiratory, thoracic
           and mediastinal
10042241   disorders               Stridor                  -




           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10065787   disorders               Tracheal fistula         intervention not indicated

           Respiratory, thoracic                            Endoscopic findings only;
           and mediastinal                                  minimal hemoptysis, pain, or
10065900   disorders               Tracheal mucositis       respiratory symptoms
           Respiratory, thoracic                            Asymptomatic; clinical or
           and mediastinal                                  diagnostic observations only;
10050816   disorders               Tracheal stenosis        intervention not indicated




           Respiratory, thoracic
           and mediastinal                                  Mild or intermittent change
10047681   disorders               Voice alteration         from normal voice


           Respiratory, thoracic
           and mediastinal                                  Detectable airway noise with
10047924   disorders               Wheezing                 minimal symptoms




                                                             Asymptomatic or mild
           Respiratory, thoracic   Respiratory, thoracic and symptoms; clinical or
           and mediastinal         mediastinal disorders - diagnostic observations only;
10038738   disorders               Other, specify            intervention not indicated


                                                            Hair loss of up to 50% of
                                                            normal for that individual
                                                            that is not obvious from a
                                                            distance but only on close
                                                            inspection; a different hair
                                                            style may be required to
                                                            cover the hair loss but it does
           Skin and subcutaneous                            not require a wig or hair
10001760   tissue disorders        Alopecia                 piece to camouflage

                                                            Mild odor; physician
           Skin and subcutaneous                            intervention not indicated;
10005901   tissue disorders        Body odor                self care interventions
           Skin and subcutaneous                         Asymptomatic; blisters
10006556   tissue disorders        Bullous dermatitis    covering <10% BSA


                                                         Covering <10% BSA and no
           Skin and subcutaneous                         associated erythema or
10013786   tissue disorders        Dry skin              pruritus


                                                         Target lesions covering <10%
           Skin and subcutaneous                         BSA and not associated with
10015218   tissue disorders        Erythema multiforme   skin tenderness




           Skin and subcutaneous
10015277   tissue disorders        Erythroderma          -




           Skin and subcutaneous                         Covering <10% BSA and
10016241   tissue disorders        Fat atrophy           asymptomatic




                                                         In women, increase in length,
                                                         thickness or density of hair in
                                                         a male distribution that the
                                                         patient is able to camouflage
           Skin and subcutaneous                         by periodic shaving,
10020112   tissue disorders        Hirsutism             bleaching, or removal of hair


                                                         Limited to one site (palms,
           Skin and subcutaneous                         soles, or axillae); self care
10020642   tissue disorders        Hyperhidrosis         interventions
                                                        Increase in length, thickness
                                                        or density of hair that the
                                                        patient is either able to
                                                        camouflage by periodic
                                                        shaving or removal of hairs or
                                                        is not concerned enough
           Skin and subcutaneous                        about the overgrowth to use
10020864   tissue disorders        Hypertrichosis       any form of hair removal

           Skin and subcutaneous
10021013   tissue disorders        Hypohidrosis         -




           Skin and subcutaneous                        Asymptomatic and covering
10062315   tissue disorders        Lipohypertrophy      <10% BSA

                                                        Asymptomatic; clinical or
           Skin and subcutaneous                        diagnostic observations only;
10028691   tissue disorders        Nail discoloration   intervention not indicated




                                                        Asymptomatic separation of
           Skin and subcutaneous                        the nail bed from the nail
10049281   tissue disorders        Nail loss            plate or nail loss

                                                        Asymptomatic; clinical or
           Skin and subcutaneous                        diagnostic observations only;
10062283   tissue disorders        Nail ridging         intervention not indicated

           Skin and subcutaneous
10033474   tissue disorders        Pain of skin         Mild pain
                                                        Minimal skin changes or
                                   Palmar-plantar       dermatitis (e.g., erythema,
           Skin and subcutaneous   erythrodysesthesia   edema, or hyperkeratosis)
10054524   tissue disorders        syndrome             without pain




           Skin and subcutaneous
10054541   tissue disorders        Periorbital edema    Soft or non-pitting




           Skin and subcutaneous                        Painless erythema and
10034966   tissue disorders        Photosensitivity     erythema covering <10% BSA




           Skin and subcutaneous                        Mild or localized; topical
10037087   tissue disorders        Pruritus             intervention indicated


           Skin and subcutaneous                        Combined area of lesions
10037549   tissue disorders        Purpura              covering <10% BSA
                                                            Papules and/or pustules
                                                            covering <10% BSA, which
                                                            may or may not be
           Skin and subcutaneous                            associated with symptoms of
10037847   tissue disorders        Rash acneiform           pruritus or tenderness




                                                            Macules/papules covering
                                                            <10% BSA with or without
           Skin and subcutaneous                            symptoms (e.g., pruritus,
10037868   tissue disorders        Rash maculo-papular      burning, tightness)

           Skin and subcutaneous
10049120   tissue disorders        Scalp pain               Mild pain
                                                            Covering <10% BSA;
                                                            associated with
           Skin and subcutaneous                            telangiectasias or changes in
10040799   tissue disorders        Skin atrophy             skin color

                                                            Hyperpigmentation covering
           Skin and subcutaneous                            <10% BSA; no psychosocial
10040865   tissue disorders        Skin hyperpigmentation   impact

                                                            Hypopigmentation or
                                                            depigmentation covering
           Skin and subcutaneous                            <10% BSA; no psychosocial
10040868   tissue disorders        Skin hypopigmentation    impact

                                                            Mild induration, able to move
                                                            skin parallel to plane (sliding)
           Skin and subcutaneous                            and perpendicular to skin
10051837   tissue disorders        Skin induration          (pinching up)
                                                             Combined area of ulcers <1
                                                             cm; nonblanchable erythema
           Skin and subcutaneous                             of intact skin with associated
10040947   tissue disorders        Skin ulceration           warmth or edema




           Skin and subcutaneous   Stevens-Johnson
10042033   tissue disorders        syndrome


           Skin and subcutaneous                             Telangiectasias covering
10043189   tissue disorders        Telangiectasia            <10% BSA




           Skin and subcutaneous   Toxic epidermal
10044223   tissue disorders        necrolysis                -


                                                             Urticarial lesions covering
           Skin and subcutaneous                             <10% BSA; topical
10046735   tissue disorders        Urticaria                 intervention indicated




                                                             Asymptomatic or mild
                                   Skin and subcutaneous symptoms; clinical or
           Skin and subcutaneous   tissue disorders - Other, diagnostic observations only;
10040785   tissue disorders        specify                   intervention not indicated

                                                             Menopause occurring at age
10027308   Social circumstances    Menopause                 46 - 53 years of age
                                                            Asymptomatic or mild
                                                            symptoms; clinical or
                                  Social circumstances -    diagnostic observations only;
10041244   Social circumstances   Other, specify            intervention not indicated




                                                            Asymptomatic or mild
                                  Surgical and medical      symptoms; clinical or
           Surgical and medical   procedures - Other,       diagnostic observations only;
10042613   procedures             specify                   intervention not indicated




10007196   Vascular disorders     Capillary leak syndrome   -

                                                            Asymptomatic; clinical or
                                                            diagnostic observations only;
10016825   Vascular disorders     Flushing                  intervention not indicated


                                                            Mild symptoms; intervention
10019428   Vascular disorders     Hematoma                  not indicated

                                                            Mild symptoms; intervention
10020407   Vascular disorders     Hot flashes               not indicated
                                                      Prehypertension (systolic BP
                                                      120 - 139 mm Hg or diastolic
10020772   Vascular disorders   Hypertension          BP 80 - 89 mm Hg)

                                                      Asymptomatic, intervention
10021097   Vascular disorders   Hypotension           not indicated




10065773   Vascular disorders   Lymph leakage         -




                                                      Trace thickening or faint
10025233   Vascular disorders   Lymphedema            discoloration

                                                      Asymptomatic; clinical or
                                                      diagnostic observations only;
10048642   Vascular disorders   Lymphocele            intervention not indicated




10034578   Vascular disorders   Peripheral ischemia   -
10034879   Vascular disorders   Phlebitis             -
                                Superficial
10042554   Vascular disorders   thrombophlebitis      -
                                Superior vena cava        Asymptomatic; incidental
10042569   Vascular disorders   syndrome                  finding of SVC thrombosis




                                                          Venous thrombosis (e.g.,
10043565   Vascular disorders   Thromboembolic event      superficial thrombosis)




                                                          Asymptomatic, intervention
10047115   Vascular disorders   Vasculitis                not indicated




10054692   Vascular disorders   Visceral arterial ischemia -




                                                          Asymptomatic or mild
                                                          symptoms; clinical or
                                Vascular disorders -      diagnostic observations only;
10047065   Vascular disorders   Other, specify            intervention not indicated
       Grade 2                       Grade 3                        Grade 4              Grade 5


Hgb <10.0 - 8.0 g/dL;   Hgb <8.0 - 6.5 g/dL; <4.9 - 4.0    Life-threatening
<6.2 - 4.9 mmol/L; <100 mmol/L; <80 - 65 g/L;              consequences; urgent
- 80g/L                 transfusion indicated              intervention indicated       Death

Moderately hypocellular
or >25 - <50% reduction Severely hypocellular or >50 -
from normal cellularity <=75% reduction cellularity    Aplastic persistent for
for age                 from normal for age            longer than 2 weeks              Death

                                                           Life-threatening
Laboratory findings with Laboratory findings and           consequences; urgent
no bleeding              bleeding                          intervention indicated       Death
                                                           Life-threatening
                                                           consequences; urgent
-                          Present                         intervention indicated       Death


Evidence of hemolysis
and >=2 gm decrease in Transfusion or medical              Life-threatening
hemoglobin, no         intervention indicated (e.g.,       consequences; urgent
transfusion            steroids)                           intervention indicated       Death
                                                           Life-threatening
                                                           consequences, (e.g., CNS
                           Laboratory findings with        hemorrhage or
                           clinical consequences (e.g.,    thrombosis/embolism or
-                          renal insufficiency, petechiae) renal failure)               Death
                                                           Clinical manifestations of
                                                           leucostasis; urgent
-                          >100,000/mm3                    intervention indicated       Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -


                                                           Life-threatening
Prophylactic antibiotics                                   consequences; urgent
indicated                   -                              intervention indicated       Death
                                                           Life-threatening
                                                           consequences, (e.g., CNS
                           Laboratory findings with        hemorrhage or
                           clinical consequences (e.g.,    thrombosis/embolism or
-                          renal insufficiency, petechiae) renal failure)               Death
                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated   Death


                          Symptomatic, unstable angina   Symptomatic, unstable
Symptomatic,              and/or acute myocardial        angina and/or acute
progressive angina;       infarction, cardiac enzymes    myocardial infarction,
cardiac enzymes normal;   abnormal, hemodynamically      cardiac enzymes abnormal,
hemodynamically stable    stable                         hemodynamically unstable Death

                                                    Life-threatening
                       Symptomatic; severe          consequences; urgent
Asymptomatic;          regurgitation or stenosis by intervention indicated (e.g.,
moderate regurgitation imaging; symptoms controlled valve replacement,
or stenosis by imaging with medical intervention    valvuloplasty)                Death
                                                    Life-threatening
                                                    consequences; urgent
-                       -                           intervention indicated        Death

                          Symptomatic and incompletely
                          controlled medically, or      Life-threatening
Non-urgent medical        controlled with device (e.g., consequences; urgent
intervention indicated    pacemaker), or ablation       intervention indicated    Death

                          Symptomatic and incompletely
                          controlled medically, or      Life-threatening
Non-urgent medical        controlled with device (e.g., consequences; urgent
intervention indicated    pacemaker), or ablation       intervention indicated    Death

                        Symptomatic and incompletely
                        controlled medically, or      Life-threatening
Non-urgent intervention controlled with device (e.g., consequences; urgent
indicated               pacemaker)                    intervention indicated      Death


Non-urgent intervention
indicated               -
                                                         Life-threatening
                                                         consequences; urgent
-                         -                              intervention indicated   Death
Moderate pain; limiting Pain at rest; limiting self care
instrumental ADL        ADL                                 -                           -
                                                           Life-threatening
                          Severe symptoms;                 consequences; urgent
Moderate symptoms         intervention indicated           intervention indicated      Death

                          Symptomatic heart failure or Refractory heart failure or
                          other cardiac symptoms,      other poorly controlled
-                         responsive to intervention   cardiac symptoms              Death
                                                       Life-threatening
                                                       consequences; urgent
                          Severe with symptoms at rest intervention indicated (e.g.,
Symptoms with mild to     or with minimal activity or  continuous IV therapy or
moderate activity or      exertion; intervention       mechanical hemodynamic
exertion                  indicated                    support)                      Death


                                                          Refractory or poorly
                                                          controlled heart failure due
                                                          to drop in ejection fraction;
                                                          intervention such as
                                                          ventricular assist device,
                          Symptomatic due to drop in      intravenous vasopressor
                          ejection fraction responsive to support, or heart
-                         intervention                    transplant indicated          Death

                                                           Life-threatening
                       Symptomatic; severe                 consequences; urgent
Asymptomatic;          regurgitation or stenosis by        intervention indicated (e.g.,
moderate regurgitation imaging; symptoms controlled        valve replacement,
or stenosis by imaging with medical intervention           valvuloplasty)                Death

                          Symptomatic and incompletely
                          controlled medically, or      Life-threatening
Symptomatic; medical      controlled with device (e.g., consequences; urgent
intervention indicated    pacemaker)                    intervention indicated         Death

                        Symptomatic and incompletely
                        controlled medically, or           Life-threatening
Symptomatic; medical controlled with device (e.g.,         consequences; urgent
intervention indicated pacemaker)                          intervention indicated      Death
Asymptomatic and        Severe symptoms; cardiac
cardiac enzymes         enzymes abnormal;
minimally abnormal and hemodynamically stable; ECG         Life-threatening
no evidence of ischemic changes consistent with            consequences;
ECG changes             infarction                         hemodynamically unstable Death
                                                         Life-threatening
                                                         consequences; urgent
                            Severe with symptoms at rest intervention indicated (e.g.,
Symptoms with mild to       or with minimal activity or  continuous IV therapy or
moderate activity or        exertion; intervention       mechanical hemodynamic
exertion                    indicated                    support)                      Death


Intervention indicated      -                               -                           -
                                                           Life-threatening
                                                           consequences;
                                                           incompletely controlled
Symptomatic; medical                                       medically; cardioversion
management indicated        IV medication indicated        indicated                   Death
                                                           Life-threatening
Asymptomatic effusion       Effusion with physiologic      consequences; urgent
size small to moderate      consequences                   intervention indicated      Death
                                                           Life-threatening
                                                           consequences; urgent
-                           -                              intervention indicated      Death

Symptomatic                 Pericarditis with physiologic   Life-threatening
pericarditis (e.g., chest   consequences (e.g., pericardial consequences; urgent
pain)                       constriction)                   intervention indicated     Death

                                                           Life-threatening
                       Symptomatic; severe                 consequences; urgent
Asymptomatic;          regurgitation or stenosis by        intervention indicated (e.g.,
moderate regurgitation imaging; symptoms controlled        valve replacement,
or stenosis by imaging with medical intervention           valvuloplasty)                Death

                            Symptomatic heart failure or   Refractory heart failure or
                            other cardiac symptoms,        other poorly controlled
-                           responsive to intervention     cardiac symptoms            Death

                                                       Life-threatening
                                                       consequences; urgent
Symptoms with mild to Severe symptoms, associated intervention indicated (e.g.,
moderate activity or    with hypoxemia, right heart    ventricular assist device);
exertion                failure; oxygen indicated      heart transplant indicated Death
                                                       Life-threatening
Non-urgent intervention Severe, medically significant; consequences; urgent
indicated               medical intervention indicated intervention indicated      Death
                                                       Life-threatening
Symptomatic, medical Severe, medically significant, consequences; urgent
intervention indicated medical intervention indicated intervention indicated       Death
Symptomatic; non-
urgent medical           Urgent medical intervention
intervention indicated   indicated                       -                              -
                                                        Life-threatening
Non-urgent medical                                      consequences; urgent
intervention indicated   Medical intervention indicated intervention indicated          Death

                                                        Life-threatening
                       Symptomatic; severe              consequences; urgent
Asymptomatic;          regurgitation or stenosis;       intervention indicated (e.g.,
moderate regurgitation symptoms controlled with         valve replacement,
or stenosis by imaging medical intervention             valvuloplasty)                  Death
                                                        Life-threatening
                                                        consequences;
                                                        hemodynamic
Non-urgent medical                                      compromise; urgent
intervention indicated   Medical intervention indicated intervention indicated          Death
                                                        Life-threatening
                                                        consequences;
                                                        hemodynamic
                                                        compromise; urgent
-                        -                              intervention indicated          Death
                                                        Life-threatening
                                                        consequences;
                                                        hemodynamic
Non-urgent medical                                      compromise; urgent
intervention indicated   Medical intervention indicated intervention indicated          Death

                         Symptomatic and incompletely Life-threatening
Non-urgent medical       controlled medically or      consequences; urgent
intervention indicated   controlled with procedure    intervention indicated            Death


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated         Death
                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated   Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                       -

External otitis with
moist desquamation,
edema, enhanced
cerumen or discharge;
tympanic membrane        External otitis with mastoiditis;
perforation;             stenosis or osteomyelitis;        Urgent operative
tympanostomy             necrosis of soft tissue or bone intervention indicated   Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                       -
                          Adults enrolled in monitoring
                          program (a 1, 2, 3, 4, 6 and 8
                          kHz audiogram): threshold
Adults enrolled in        shift of >25 dB averaged at 3
monitoring program (a     contiguous test frequencies in
1, 2, 3, 4, 6 and 8 kHz   at least one ear; therapeutic
audiogram): threshold     intervention indicated
shift of >25 dB averaged
at 2 contiguous test        Adults not enrolled in
frequencies in at least monitoring program: hearing
one ear                    loss with hearing aid or
                           intervention indicated; limiting
Adult not enrolled in      self care ADL                      Adults: profound bilateral
monitoring program:                                           hearing loss (>80 dB at 2
hearing loss but hearing Pediatric (a 1, 2, 3, 4, 6 and 8     kHz and above); non-
aid or intervention not kHz audiogram): hearing loss          serviceable hearing
indicated; limiting        sufficient to indicate
instrumental ADL           therapeutic intervention,          Pediatric: audiologic
                           including hearing aids; >20 dB     indication for cochlear
Pediatric (a 1, 2, 3, 4, 6 at 3 kHz and above in one ear;     implant and additional
and 8 kHz audiogram): additional speech-language              speech-language related
>20 dB at >4 kHz           related services indicated         services indicated           -
                                                              Life-threatening
Serous otitis, medical    Mastoiditis; necrosis of canal      consequences; urgent
intervention indicated    soft tissue or bone                 intervention indicated       Death
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                                 -
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                                 -

Symptomatic; limiting     Severe symptoms; limiting self
instrumental ADL          care ADL                       -                                 -


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated            Death
Moderate symptoms;                                         Life-threatening
medical intervention        Severe symptoms;               consequences; urgent
indicated                   hospitalization indicated      intervention indicated    Death

Moderate symptoms;          Severe symptoms, medical
medical intervention        intervention or hospitalization
indicated                   indicated                       -                        -

No breast development       No breast development by age
by age 13 yrs for           14 yrs for females; no increase
females; testes volume      in testes volume or no Tanner
of <3 cc or no Tanner       Stage 2 by age 16 yrs for
Stage 2 development by      males; hormone replacement
age 14.5 yrs for males      indicated                       -                        -
>= +2 SD (standard
deviation) above mid
parental height or target
height                      -                               -                        -
Moderate symptoms;
medical intervention
indicated                   -                               -                        -
Symptomatic; thyroid
suppression therapy         Severe symptoms; limiting self Life-threatening
indicated; limiting         care ADL; hospitalization      consequences; urgent
instrumental ADL            indicated                      intervention indicated    Death

Moderate symptoms;          Severe symptoms; medical        Life-threatening
medical intervention        intervention or hospitalization consequences; urgent
indicated                   indicated                       intervention indicated   Death
Symptomatic; thyroid
replacement indicated;      Severe symptoms; limiting self Life-threatening
limiting instrumental       care ADL; hospitalization      consequences; urgent
ADL                         indicated                      intervention indicated    Death
Physical signs and
biochemical markers of
puberty for females <8
years and males <9
years                       -                               -                        -
Moderate symptoms;
medical intervention
indicated                   -                               -                        -
                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated          Death

Symptomatic; limiting
instrumental ADL          Limiting self care ADL            -                            -

                          Symptomatic with marked
                          decrease in visual acuity
                          (worse than 20/40 but better
Symptomatic; moderate than 20/200); operative
decrease in visual acuity intervention indicated (e.g.,     Blindness (20/200 or
(20/40 or better)         cataract surgery)                 worse) in the affected eye   -
Symptomatic; topical
intervention indicated
(e.g., antibiotics);
limiting instrumental
ADL                       Limiting self care ADL            -                            -

Symptomatic; medical
intervention indicated
(e.g., topical agents);   Limiting self care ADL;       Perforation or blindness
limiting instrumental     declining vision (worse than  (20/200 or worse) in the
ADL                       20/40 but better than 20/200) affected eye                     -
Symptomatic; multiple
agents indicated;
limiting instrumental     Decrease in visual acuity
ADL                       (<20/40); limiting self care ADL -                             -

Symptomatic; limiting     Limiting self care ADL;
instrumental ADL          disabling                         -                            -

Moderate pain; limiting   Severe pain; limiting self care
instrumental ADL          ADL                               -                            -
Symptomatic;
nonoperative
intervention indicated;   Limiting self care ADL;
limiting instrumental     operative intervention
ADL                       indicated                         -                            -
Limiting instrumental
ADL                       Limiting self care ADL            -                            -
Limiting instrumental
ADL                           Limiting self care ADL            -                            -

                          EIOP causing marked visual
EIOP causing early visual field deficits (e.g., involving
field deficits; multiple  both superior and inferior
topical or oral agents    visual fields); operative
indicated; limiting       intervention indicated; limiting Blindness (20/200 or
instrumental ADL          self care ADL                    worse) in the affected eye        -

Symptomatic; medical
intervention indicated
(e.g., topical agents);       Decline in vision (worse than Perforation or blindness
limiting instrumental         20/40 but better than 20/200); (20/200 or worse) in the
ADL                           limiting self care ADL         affected eye                    -

Limiting instrumental                                           Blindness (20/200 or
ADL                           Limiting self care ADL            worse) in the affected eye   -

Limiting vision of the        Limiting vision in the affected
affected eye (20/40 or        eye (worse than 20/40 but         Blindness (20/200 or
better)                       better than 20/200)               worse) in the affected eye   -

Symptomatic decline in
vision; visual field defect   Marked visual field defect
present sparing the           (worse than 20/40 but better      Blindness (20/200 or
central 20 degrees            than 20/200)                      worse) in the affected eye   -
Limiting instrumental
ADL                           Limiting self care ADL            -                            -

                              Rhegmatogenous or exudative
                              detachment; operative
                              intervention indicated; decline
Exudative and visual          in vision (worse than 20/40     Blindness (20/200 or
acuity 20/40 or better        but better than 20/200)         worse) in the affected eye     -

Laser therapy or              Vitroretinal surgical repair      Blindness (20/200 or
pneumopexy indicated          indicated                         worse) in the affected eye   -
                              Intravitreal medication;
Topical medication            operative intervention
indicated                     indicated                         -                            -
Symptomatic with
moderate decrease in      Symptomatic with marked
visual acuity (20/40 or   decrease in visual acuity
better); limiting         (worse than 20/40); disabling; Blindness (20/200 or
instrumental ADL          limiting self care ADL         worse) in the affected eye     -

Symptomatic, limiting
instrumental ADL;
moderate decrease in      Symptomatic, limiting self care
visual acuity (20/40 or   ADL; marked decrease in visual Blindness (20/200 or
better)                   acuity (worse than 20/40)       worse) in the affected eye    -

Anterior uveitis; medical                                  Blindness (20/200 or
intervention indicated Posterior or pan-uveitis            worse) in the affected eye   -


Symptomatic; limiting     Limiting self care ADL;          Blindness (20/200 or
instrumental ADL          vitrectomy indicated             worse) in the affected eye   -
                          Operative intervention
Intervention indicated    indicated                        -                            -


                         Severe or medically significant
                         but not immediately sight-
Moderate; minimal,       threatening; hospitalization or   Sight-threatening
local or noninvasive     prolongation of existing          consequences; urgent
intervention indicated; hospitalization indicated;         intervention indicated;
limiting age-appropriate disabling; limiting self care     blindness (20/200 or
instrumental ADL         ADL                               worse) in the affected eye   -


Symptomatic; limiting     Severe discomfort; limiting self
instrumental ADL          care ADL                         -                            -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -                            -

                        Severely altered GI function;
                        tube feeding, TPN or
                        hospitalization indicated;      Life-threatening
Symptomatic; altered GI elective operative intervention consequences; urgent
function                indicated                       intervention indicated          Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective          Life-threatening
minor cauterization       operative intervention           consequences; urgent
indicated                 indicated                        intervention indicated       Death
Symptomatic; medical
intervention indicated;                                  Life-threatening
limiting instrumental     Severe symptoms; limiting self consequences; urgent
ADL                       care ADL                       intervention indicated    Death
                          TPN or hospitalization         Life-threatening
                          indicated; radiologic,         consequences; urgent
                          endoscopic, or operative       operative intervention
-                         intervention indicated         indicated                 Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -

                        Symptomatic and severely
                        altered GI function; non-         Life-threatening
                        emergent operative                consequences; urgent
Symptomatic; altered GI intervention indicated; TPN or    operative intervention
function                hospitalization indicated         indicated                Death
                        Severely altered GI function;
                        TPN indicated; elective           Life-threatening
                        operative or endoscopic           consequences; urgent
Symptomatic; altered GI intervention indicated;           operative intervention
function                disabling                         indicated                Death
                                                          Life-threatening
                                                          consequences; urgent
Symptomatic; medical      Severe symptoms; invasive       operative intervention
intervention indicated    intervention indicated          indicated                Death

Symptomatic, decreased
oral intake; change in
bowel function         -                                  -                        -

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective         Life-threatening
minor cauterization       operative intervention          consequences; urgent
indicated                 indicated                       intervention indicated   Death

Moderate symptoms;    Severe symptoms; limiting self
limiting instrumental care ADL; intervention
ADL                   indicated                           -                        -
                      Severe abdominal pain;
                      change in bowel habits;             Life-threatening
Abdominal pain; mucus medical intervention                consequences; urgent
or blood in stool     indicated; peritoneal signs         intervention indicated   Death
                        Severely altered GI function;
                        bowel rest, TPN or
                        hospitalization indicated;      Life-threatening
Symptomatic; altered GI elective operative intervention consequences; urgent
function                indicated                       intervention indicated       Death

Moderate symptoms;         Transfusion, radiologic,
medical intervention or    endoscopic, or elective      Life-threatening
minor cauterization        operative intervention       consequences; urgent
indicated                  indicated                    intervention indicated       Death
                                                        Life-threatening
                        Hospitalization indicated;      consequences; urgent
Symptomatic; altered GI elective operative intervention operative intervention
function                indicated; disabling            indicated                    Death
                        Severe symptoms; elective       Life-threatening
Symptomatic; medical operative intervention             consequences; urgent
intervention indicated indicated                        intervention indicated       Death

                        Severely altered GI function;       Life-threatening
                        tube feeding or hospitalization     consequences; urgent
Symptomatic; altered GI indicated; elective operative       operative intervention
function                intervention indicated              indicated                Death
                        Severely altered GI function;
                        TPN indicated; elective             Life-threatening
                        operative or endoscopic             consequences; urgent
Symptomatic; altered GI intervention indicated;             operative intervention
function                disabling                           indicated                Death

Persistent symptoms
with regular use of
laxatives or enemas;       Obstipation with manual        Life-threatening
limiting instrumental      evacuation indicated; limiting consequences; urgent
ADL                        self care ADL                  intervention indicated     Death

                           Dental caries resulting in
Dental caries involving    pulpitis or periapical abscess
the root                   or resulting in tooth loss       -                        -


                           Increase of >=7 stools per day
Increase of 4 - 6 stools   over baseline; incontinence;
per day over baseline;     hospitalization indicated;
moderate increase in       severe increase in ostomy      Life-threatening
ostomy output              output compared to baseline; consequences; urgent
compared to baseline       limiting self care ADL         intervention indicated     Death
Moderate symptoms;
oral intake alterations
(e.g., copious water,
other lubricants, diet
limited to purees and/or   Inability to adequately aliment
soft, moist foods);        orally; tube feeding or TPN
unstimulated saliva 0.1    indicated; unstimulated saliva
to 0.2 ml/min              <0.1 ml/min                     -                           -

                        Severely altered GI function;
                        tube feeding, TPN or
                        hospitalization indicated;      Life-threatening
Symptomatic; altered GI elective operative intervention consequences; urgent
function                indicated                       intervention indicated         Death

Moderate symptoms;         Transfusion, radiologic,
medical intervention or    endoscopic, or elective            Life-threatening
minor cauterization        operative intervention             consequences; urgent
indicated                  indicated                          intervention indicated   Death
                                                              Life-threatening
                        Hospitalization or elective           consequences; urgent
Symptomatic; altered GI operative intervention                operative intervention
function                indicated; disabling                  indicated                Death
                                                              Life-threatening
                           Severe symptoms; elective          consequences; urgent
Symptomatic; medical       operative intervention             operative intervention
intervention indicated     indicated                          indicated                Death

                        Severely altered GI function;         Life-threatening
                        tube feeding; hospitalization         consequences; urgent
Symptomatic; altered GI indicated; elective operative         operative intervention
function                intervention indicated                indicated                Death

                           Severely altered GI function;
Moderate symptoms;         TPN indicated; elective            Life-threatening
medical intervention       operative or endoscopic            consequences; urgent
indicated; limiting        intervention indicated; limiting   operative intervention
instrumental ADL           self care ADL; disabling           indicated                Death
Moderate symptoms;
medical intervention       Severe symptoms; surgical
indicated                  intervention indicated
                           Severely altered
Symptomatic and            eating/swallowing; tube            Life-threatening
altered                    feeding or TPN or                  consequences; urgent
eating/swallowing          hospitalization indicated          intervention indicated   Death
                      Severe or persistent                  Life-threatening
Abdominal pain; mucus abdominal pain; fever; ileus;         consequences; urgent
or blood in stool     peritoneal signs                      intervention indicated   Death

Symptomatic;                                            Life-threatening
noninvasive intervention Severe, medically significant; consequences; urgent
indicated                medical intervention indicated intervention indicated       Death

                        Severely altered GI function;
                        tube feeding, TPN or
                        hospitalization indicated;      Life-threatening
Symptomatic; altered GI elective operative intervention consequences; urgent
function                indicated                       intervention indicated       Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective           Life-threatening
minor cauterization       operative intervention            consequences; urgent
indicated                 indicated                         intervention indicated   Death

                          Inability to aliment adequately   Life-threatening
                          by GI tract; radiologic,          consequences; urgent
                          endoscopic, or operative          operative intervention
-                         intervention indicated            indicated                Death

                        Hospitalization indicated;
Symptomatic; altered GI elective operative intervention Life-threatening
function; limiting      indicated; limiting self care   consequences; urgent
instrumental ADL        ADL; disabling                  intervention indicated       Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                  -                       -
                                                            Life-threatening
                          Severe symptoms; elective         consequences; urgent
Symptomatic; medical      operative intervention            operative intervention
intervention indicated    indicated                         indicated                Death

                        Severely altered GI function;       Life-threatening
                        tube feeding; hospitalization       consequences; urgent
Symptomatic; altered GI indicated; elective operative       operative intervention
function                intervention indicated              indicated                Death

                        Severely altered GI function;
                        TPN indicated; elective             Life-threatening
Symptomatic; altered GI operative or endoscopic             consequences; urgent
function; limiting      intervention indicated; limiting    operative intervention
instrumental ADL        self care ADL; disabling            indicated                Death
                        Transfusion, radiologic,
Self-limited;           endoscopic, or elective              Life-threatening
intervention not        operative intervention               consequences; urgent
indicated               indicated                            intervention indicated   Death
                        Severely altered                     Life-threatening
Symptomatic; altered    eating/swallowing; tube              consequences; urgent
eating/swallowing; oral feeding, TPN or hospitalization      operative intervention
supplements indicated indicated                              indicated                Death
                        Severe symptoms; elective
Daily use of pads       operative intervention
required                indicated                            -                        -


Moderate; persistent;
psychosocial sequelae     -                                  -                        -

                        Severely altered GI function;
                        bowel rest; tube feeding, TPN        Life-threatening
                        or hospitalization indicated;        consequences; urgent
Symptomatic; altered GI elective operative intervention      operative intervention
function                indicated                            indicated                Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective            Life-threatening
minor cauterization       operative intervention             consequences; urgent
indicated                 indicated                          intervention indicated   Death

                          Inability to aliment adequately    Life-threatening
                          by GI tract; radiologic,           consequences; urgent
                          endoscopic, or operative           operative intervention
-                         intervention indicated             indicated                Death
                                                             Life-threatening
                          Severe symptoms; elective          consequences; urgent
Symptomatic; medical      operative intervention             operative intervention
intervention indicated    indicated                          indicated                Death

                        Severely altered GI function;        Life-threatening
                        tube feeding; hospitalization        consequences; urgent
Symptomatic; altered GI indicated; elective operative        operative intervention
function                intervention indicated               indicated                Death

Symptomatic; altered GI   Severely altered GI function;
function; medical         TPN indicated; elective            Life-threatening
intervention indicated;   operative or endoscopic            consequences; urgent
limiting instrumental     intervention indicated; limiting   operative intervention
ADL                       self care ADL; disabling           indicated                Death
                                                            Life-threatening
Symptomatic; altered GI Severely altered eating or          consequences; urgent
function; medical       gastric function; TPN or            operative intervention
intervention indicated hospitalization indicated            indicated                Death


Moderate symptoms;
medical intervention      Severe symptoms; surgical
indicated                 intervention indicated             -                       -
                                                            Life-threatening
                        Severely altered GI function;       consequences; urgent
Symptomatic; altered GI tube feeding, TPN or                operative intervention
function                hospitalization indicated           indicated                Death

Moderate pain; limiting   Severe pain; limiting self care
instrumental ADL          ADL                               -                        -
Moderate symptoms;
able to maintain
nutrition with dietary
and lifestyle
modifications; may need   Weight loss; refractory to
pharmacologic             medical intervention; unable
intervention              to maintain nutrition orally      -                        -
Moderate pain
interfering with oral     Severe pain; inability to
intake                    aliment orally                    -                        -

Moderate symptoms;      Transfusion, radiologic,
medical intervention or endoscopic, or elective             Life-threatening
minor cauterization     operative intervention              consequences; urgent
indicated               indicated                           intervention indicated   Death
                        Severe symptoms; radiologic,
Symptomatic; banding endoscopic or elective
or medical intervention operative intervention
indicated               indicated                           -                        -

                        Severely altered GI function;
                        TPN or hospitalization              Life-threatening
Symptomatic; altered GI indicated; elective operative       consequences; urgent
function                intervention indicated              intervention indicated   Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective           Life-threatening
minor cauterization       operative intervention            consequences; urgent
indicated                 indicated                         intervention indicated   Death
                        Hospitalization indicated;        Life-threatening
Symptomatic; altered GI elective operative intervention   consequences; urgent
function; limiting      indicated; limiting self care     operative intervention
instrumental ADL        ADL; disabling                    indicated                Death
                                                          Life-threatening
                          Severe symptoms; elective       consequences; urgent
Symptomatic; medical      operative intervention          operative intervention
intervention indicated    indicated                       indicated                Death

                        Severely altered GI function;     Life-threatening
                        tube feeding or hospitalization   consequences; urgent
Symptomatic; altered GI indicated; elective operative     operative intervention
function                intervention indicated            indicated                Death
                        Severely altered GI function;
                        TPN indicated; elective           Life-threatening
                        operative or endoscopic           consequences; urgent
Symptomatic; altered GI intervention indicated;           operative intervention
function                disabling                         indicated                Death
Symptomatic; altered GI                                   Life-threatening
function; bowel rest    Severely altered GI function;     consequences; urgent
indicated               TPN indicated                     intervention indicated   Death
                        Transfusion, radiologic,
Medical intervention or endoscopic, or elective           Life-threatening
minor cauterization     operative intervention            consequences; urgent
indicated               indicated                         intervention indicated   Death

                        Severely altered GI function;
                        TPN or hospitalization            Life-threatening
Symptomatic; altered GI indicated; elective operative     consequences; urgent
function                intervention indicated            intervention indicated   Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective         Life-threatening
minor cauterization       operative intervention          consequences; urgent
indicated                 indicated                       intervention indicated   Death

                        Hospitalization indicated;        Life-threatening
Symptomatic; altered GI elective operative intervention   consequences; urgent
function; limiting      indicated; limiting self care     operative intervention
instrumental ADL        ADL; disabling                    indicated                Death
                                                          Life-threatening
                          Severe symptoms; elective       consequences; urgent
Symptomatic; medical      operative intervention          operative intervention
intervention indicated    indicated                       indicated                Death
                        Severely altered GI function;     Life-threatening
                        tube feeding or hospitalization   consequences; urgent
Symptomatic; altered GI indicated; elective operative     operative intervention
function                intervention indicated            indicated                Death
                        Severely altered GI function;
                        TPN indicated; elective           Life-threatening
                        operative or endoscopic           consequences; urgent
Symptomatic; altered GI intervention indicated;           operative intervention
function                disabling                         indicated                Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective         Life-threatening
minor cauterization       operative intervention          consequences; urgent
indicated                 indicated                       intervention indicated   Death
                                                          Life-threatening
Altered diet; oral        Inability to aliment            consequences; urgent
intervention indicated    adequately; TPN indicated       intervention indicated   Death
Moderate pain; not
interfering with oral                                     Life-threatening
intake; modified diet     Severe pain; interfering with   consequences; urgent
indicated                 oral intake                     intervention indicated   Death

Oral intake decreased
without significant      Inadequate oral caloric or fluid
weight loss, dehydration intake; tube feeding, TPN, or
or malnutrition          hospitalization indicated        -                        -

                        Hospitalization indicated;        Life-threatening
Symptomatic; altered GI elective operative intervention   consequences; urgent
function; limiting      indicated; limiting self care     operative intervention
instrumental ADL        ADL; disabling                    indicated                Death

                        Severely altered GI function;
                        TPN or hospitalization            Life-threatening
Symptomatic; altered GI indicated; elective operative     consequences; urgent
function                intervention indicated            intervention indicated   Death
Moderate pain;
interfering with oral   Disabling pain; tube feeding or
intake                  TPN indicated                     -                        -
Moderate symptoms;         Transfusion, radiologic,
medical intervention or    endoscopic, or elective          Life-threatening
minor cauterization        operative intervention           consequences; urgent
indicated                  indicated                        intervention indicated   Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                        -

                        Severely altered GI function;       Life-threatening
                        tube feeding or hospitalization     consequences; urgent
Symptomatic; altered GI indicated; elective operative       operative intervention
function                intervention indicated              indicated                Death

                        Severely altered GI function;
                        tube feeding or TPN or              Life-threatening
                        hospitalization indicated;          consequences; urgent
Symptomatic; altered GI elective operative intervention     operative intervention
function                indicated                           indicated                Death

Moderate symptoms;         Transfusion, radiologic,
medical intervention or    endoscopic, or elective          Life-threatening
minor cauterization        operative intervention           consequences; urgent
indicated                  indicated                        intervention indicated   Death
                           Tube feeding or TPN indicated;   Life-threatening
                           radiologic, endoscopic, or       consequences; urgent
                           operative intervention           operative intervention
-                          indicated                        indicated                Death

                           Severe pain; vomiting; medical Life-threatening
Enzyme elevation or        intervention indicated (e.g.,   consequences; urgent
radiologic findings only   analgesia, nutritional support) intervention indicated    Death

Moderate gingival
recession or gingivitis;   Spontaneous bleeding; severe
multiple sites of          bone loss with or without
bleeding on probing;       tooth loss; osteonecrosis of
moderate bone loss         maxilla or mandible               -                       -
                           Tube feeding or TPN              Life-threatening
                           indicated; radiologic,           consequences; urgent
                           endoscopic, or operative         operative intervention
-                          intervention indicated           indicated                Death
Symptoms (e.g., rectal
discomfort, passing
blood or mucus);
medical intervention      Severe symptoms; fecal         Life-threatening
indicated; limiting       urgency or stool incontinence; consequences; urgent
instrumental ADL          limiting self care ADL         intervention indicated      Death

                        Severely altered GI function;
                        TPN or hospitalization              Life-threatening
Symptomatic; altered GI indicated; elective operative       consequences; urgent
function                intervention indicated              intervention indicated   Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective        Life-threatening
minor cauterization       operative intervention         consequences; urgent
indicated                 indicated                      intervention indicated      Death
Symptomatic; medical                                     Life-threatening
intervention indicated;                                  consequences; urgent
limiting instrumental     Severe symptoms; limiting self operative intervention
ADL                       care ADL                       indicated                   Death
                          Tube feeding or TPN indicated; Life-threatening
                          radiologic, endoscopic, or     consequences; urgent
                          operative intervention         operative intervention
-                         indicated                      indicated                   Death

                        Hospitalization indicated;          Life-threatening
Symptomatic; altered GI elective operative intervention     consequences; urgent
function; limiting      indicated; limiting self care       operative intervention
instrumental ADL        ADL; disabling                      indicated                Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                  -                       -
                                                            Life-threatening
                          Severe symptoms; elective         consequences; urgent
Symptomatic; medical      operative intervention            operative intervention
intervention indicated    indicated                         indicated                Death

                          Severely altered GI function;     Life-threatening
                          tube feeding or hospitalization   consequences; urgent
Symptomatic; altered GI indicated; elective operative       operative intervention
function                  intervention indicated            indicated                Death
                          Severely altered GI function;
Symptomatic; altered GI TPN indicated; elective             Life-threatening
function (e.g. altered    operative or endoscopic           consequences; urgent
dietary habits, vomiting, intervention indicated;           operative intervention
diarrhea)                 disabling                         indicated                Death
                              Transfusion, medical,
                              radiologic, endoscopic, or      Life-threatening
Self-limited;                 elective operative intervention consequences; urgent
intervention indicated        indicated                       intervention indicated   Death

Thick, ropy, sticky saliva;   Acute salivary gland necrosis;
markedly altered taste;       severe secretion-induced
alteration in diet            symptoms (e.g., thick
indicated; secretion-         saliva/oral secretions or
induced symptoms;             gagging); tube feeding or TPN Life-threatening
limiting instrumental         indicated; limiting self care  consequences; urgent
ADL                           ADL; disabling                 intervention indicated    Death

                        Severely altered GI function;        Life-threatening
Symptomatic; altered GI hospitalization indicated;           consequences; urgent
function; tube feeding elective operative intervention       operative intervention
indicated               indicated                            indicated                 Death

Symptomatic; medical          Severe pain; interfering with
intervention indicated;       oral intake; tube feeding, TPN Life-threatening
limiting instrumental         or hospitalization indicated;  consequences; urgent
ADL                           limiting self care ADL         intervention indicated    Death

                        Hospitalization indicated;           Life-threatening
Symptomatic; altered GI elective operative intervention      consequences; urgent
function; limiting      indicated; limiting self care        operative intervention
instrumental ADL        ADL; disabling                       indicated                 Death
                                                             Life-threatening
                        Severe symptoms; elective            consequences; urgent
Symptomatic; medical operative intervention                  operative intervention
intervention indicated indicated                             indicated                 Death
                        Symptomatic and severely
                        altered GI function; tube
                        feeding, TPN or hospitalization      Life-threatening
                        indicated; non-emergent              consequences; urgent
Symptomatic; altered GI operative intervention               operative intervention
function                indicated                            indicated                 Death

                        Severely altered GI function;
                        TPN indicated; elective              Life-threatening
Symptomatic; altered GI operative or endoscopic              consequences; urgent
function; limiting      intervention indicated; limiting     operative intervention
instrumental ADL        self care ADL; disabling             indicated                 Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                   -                        -
                       Maldevelopment with
Impairment correctable impairment not surgically
with oral surgery      correctable; disabling               -                        -

-                         -                                 -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                        -

                          Symptomatic (e.g., abdominal      Life-threatening
                          pain, fever, change in bowel      consequences; urgent
                          habits with ileus); peritoneal    operative intervention
-                         signs                             indicated                Death

Moderate symptoms;        Transfusion, radiologic,
medical intervention or   endoscopic, or elective           Life-threatening
minor cauterization       operative intervention            consequences; urgent
indicated                 indicated                         intervention indicated   Death
                          >=6 episodes (separated by 5
3 - 5 episodes            minutes) in 24 hrs; tube          Life-threatening
(separated by 5           feeding, TPN or hospitalization   consequences; urgent
minutes) in 24 hrs        indicated                         intervention indicated   Death


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated      Death
Moderate tremor of the
entire body; narcotics   Severe or prolonged, not
indicated                responsive to narcotics          -                          -


-                         -                                 -                        Death


 -                        -                                 -                        Death
Moderate localized
facial edema; limiting    Severe swelling; limiting self
instrumental ADL          care ADL                          -                        -
>10 - 30% inter-limb
discrepancy in volume
or circumference at
point of greatest visible
difference; readily
apparent obscuration of
anatomic architecture;
obliteration of skin
folds; readily apparent
deviation from normal       >30% inter-limb discrepancy in
anatomic contour;           volume; gross deviation from
limiting instrumental       normal anatomic contour;
ADL                         limiting self care ADL         -                            -


Readily apparent
obscuration of anatomic
architecture;
obliteration of skin
folds; readily apparent
deviation from normal
anatomic contour;       Gross deviation from normal
limiting instrumental   anatomic contour; limiting self
ADL                     care ADL                        -                               -

Moderate pain; limiting     Severe pain; limiting self care
instrumental ADL            ADL                               -                         -
Fatigue not relieved by
rest; limiting              Fatigue not relieved by rest,
instrumental ADL            limiting self care ADL            -                         -

>39.0 - 40.0 degrees C      >40.0 degrees C (>104.0           >40.0 degrees C (>104.0
(102.3 - 104.0 degrees F)   degrees F) for <=24 hrs           degrees F) for >24 hrs    Death
Moderate symptoms;
limiting instrumental       Severe symptoms; limiting self
ADL                         care ADL                       -                            -

Moderate change in gait
(e.g., wide-based,
limping or hobbling);
assistive device
indicated; limiting     Disabling; limiting self care
instrumental ADL        ADL                                   -                         -
                                                          <=28 degrees C; 82.4
                                                          degrees F; life-threatening
                                                          consequences (e.g., coma,
                                                          hypotension, pulmonary
35 - >32 degrees C; 95 - 32 - >28 degrees C; 89.6 -       edema, acidemia,
>89.6 degrees F          >82.4 degrees F                  ventricular fibrillation)   Death

Therapy or infusion
interruption indicated
but responds promptly     Prolonged (e.g., not rapidly
to symptomatic            responsive to symptomatic
treatment (e.g.,          medication and/or brief
antihistamines, NSAIDS,   interruption of infusion);
narcotics, IV fluids);    recurrence of symptoms
prophylactic              following initial improvement; Life-threatening
medications indicated     hospitalization indicated for  consequences; urgent
for <=24 hrs              clinical sequelae              intervention indicated       Death
Erythema with
associated symptoms       Ulceration or necrosis; severe Life-threatening
(e.g., edema, pain,       tissue damage; operative       consequences; urgent
induration, phlebitis)    intervention indicated         intervention indicated       Death

                          Ulceration or necrosis; severe Life-threatening
Pain; lipodystrophy;      tissue damage; operative       consequences; urgent
edema; phlebitis          intervention indicated         intervention indicated       Death
Moderate; limiting
instrumental ADL;         Severe abnormal or excessive
increased attention       response; limiting self care
indicated                 ADL; inconsolable                -                          -

Moderate localized
edema and intervention    Severe localized edema and
indicated; limiting       intervention indicated; limiting
instrumental ADL          self care ADL                    -                          -
Uneasiness or lack of
well being; limiting
instrumental ADL          -                               -                           -
                                                         Life-threatening
                                                         consequences (e.g.,
                                                         vasopressor dependent
                          Shock with azotemia and acid- and oliguric or anuric or
                          base disturbances; significant ischemic colitis or lactic
-                         coagulation abnormalities      acidosis)                    Death
Moderate neck edema;
slight obliteration of
anatomic landmarks;    Generalized neck edema (e.g.,
limiting instrumental  difficulty in turning neck);
ADL                    limiting self care ADL        -                              -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -                        -


-                         -                                -                        Death


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated     Death

                        Severely altered GI function;      Life-threatening
Symptomatic; altered GI radiologic, endoscopic or          consequences; urgent
function; IV fluids     elective operative intervention    operative intervention
indicated <24 hrs       indicated                          indicated                Death

                         Severely altered GI function;
                         TPN indicated; endoscopic         Life-threatening
Symptomatic and          intervention indicated;           consequences; urgent
intervention not         elective operative intervention   operative intervention
indicated                indicated                         indicated                Death
                         Severe symptoms; radiologic,      Life-threatening
                         endoscopic or elective            consequences; urgent
Symptomatic; medical     operative intervention            operative intervention
intervention indicated   indicated                         indicated                Death
                         Symptomatic or severely
                         altered GI function; TPN
                         indicated; radiologic,            Life-threatening
Symptomatic and          endoscopic or elective            consequences; urgent
intervention not         operative intervention            operative intervention
indicated                indicated                         indicated                Death
                                                          Life-threatening
                                                          consequences; urgent
                                                          radiologic or operative
-                        -                                intervention indicated     Death
                        Symptomatic and severely
                        altered GI function; tube
                        feeding, TPN or hospitalization   Life-threatening
Symptomatic; altered GI indicated; non-emergent           consequences; urgent
function; IV fluids     operative intervention            operative intervention
indicated <24 hrs       indicated                         indicated                  Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -                         -
                                                          Life-threatening
                                                          consequences; urgent
-                         -                               intervention indicated     Death

                         Asterixis; mild                  Moderate to severe
                         encephalopathy; limiting self    encephalopathy; coma; life-
-                        care ADL                         threatening consequences Death
                                                          Life-threatening
Symptomatic; medical                                      consequences; urgent
intervention indicated   Transfusion indicated            intervention indicated      Death
                                                          Life-threatening
                                                          consequences; urgent
                                                          radiologic or operative
-                         -                               intervention indicated      Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                          -
                                                         Life-threatening
                         Radiologic, endoscopic or       consequences; urgent
                         elective operative intervention operative intervention
-                        indicated                       indicated                   Death
                         Reversal/retrograde portal      Life-threatening
Decreased portal vein    vein flow; associated with      consequences; urgent
flow                     varices and/or ascites          intervention indicated      Death
                                                         Life-threatening
Intervention not                                         consequences; urgent
indicated                Medical intervention indicated intervention indicated       Death
                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated         Death

                         Prolonged (e.g., not rapidly
Intervention or infusion responsive to symptomatic
interruption indicated; medication and/or brief
responds promptly to     interruption of infusion);
symptomatic treatment recurrence of symptoms
(e.g., antihistamines,   following initial improvement;
NSAIDS, narcotics);      hospitalization indicated for
prophylactic             clinical sequelae (e.g., renal Life-threatening
medications indicated impairment, pulmonary             consequences; urgent
for <=24 hrs             infiltrates)                   intervention indicated          Death

                            Symptomatic bronchospasm,
                            with or without urticaria;
                            parenteral intervention
                            indicated; allergy-related       Life-threatening
                            edema/angioedema;                consequences; urgent
-                           hypotension                      intervention indicated     Death

Evidence of
autoimmune reaction         Autoimmune reactions
involving a non-essential   involving major organ (e.g.,     Life-threatening
organ or function (e.g.,    colitis, anemia, myocarditis,    consequences; urgent
hypothyroidism)             kidney)                          intervention indicated     Death

Therapy or infusion         Prolonged (e.g., not rapidly
interruption indicated      responsive to symptomatic
but responds promptly       medication and/or brief
to symptomatic              interruption of infusion);
treatment (e.g.,            recurrence of symptoms
antihistamines, NSAIDS,     following initial improvement;
narcotics, IV fluids);      hospitalization indicated for    Life-threatening
prophylactic                clinical sequelae (e.g., renal   consequences; pressor or
medications indicated       impairment, pulmonary            ventilatory support
for <=24 hrs                infiltrates)                     indicated                  Death
                                                           Life-threatening
Moderate arthralgia;     Severe arthralgia or arthritis;   consequences; pressor or
fever, rash, urticaria,  extensive rash; steroids or IV    ventilatory support
antihistamines indicated fluids indicated                  indicated                  Death


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;         Life-threatening
limiting age-appropriate disabling; limiting self care     consequences; urgent
instrumental ADL         ADL                               intervention indicated     Death
                         IV antibiotic, antifungal, or
                         antiviral intervention
                         indicated; radiologic or          Life-threatening
                         operative intervention            consequences; urgent
 -                       indicated                         intervention indicated     Death
                         IV antibiotic, antifungal, or
Oral intervention        antiviral intervention
indicated (e.g.,         indicated; radiologic,            Life-threatening
antibiotic, antifungal,  endoscopic, or operative          consequences; urgent
antiviral)               intervention indicated            intervention indicated     Death
                         IV antibiotic, antifungal, or
                         antiviral intervention
                         indicated; radiologic or          Life-threatening
                         operative intervention            consequences; urgent
 -                       indicated                         intervention indicated     Death


                          Severe symptoms; elective        Life-threatening
Symptomatic; medical      operative intervention           consequences; urgent
intervention indicated    indicated                        intervention indicated     Death
                          IV antibiotic, antifungal, or
                          antiviral intervention
                          indicated; radiologic or         Life-threatening
                          operative intervention           consequences; urgent
-                         indicated                        intervention indicated     Death
                          IV antibiotic, antifungal, or
                          antiviral intervention
                          indicated; radiologic or         Life-threatening
                          operative intervention           consequences; urgent
-                         indicated                        intervention indicated     Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,          Life-threatening
antibiotic, antifungal,      endoscopic, or operative        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
 -                           indicated                       intervention indicated   Death
Local infection with
moderate symptoms;
oral intervention            Severe infection; axillary
indicated (e.g.,             adenitis; IV antibacterial,     Life-threatening
antibiotic, antifungal,      antifungal, or antiviral        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,          Life-threatening
antibiotic, antifungal,      endoscopic, or operative        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death

Localized; local
intervention indicated;      IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic,          Life-threatening
                             endoscopic, or operative        consequences; urgent
-                            intervention indicated          intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
-                            indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
-                            indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
Moderate symptoms;           antiviral intervention
medical intervention         indicated; radiologic or        Life-threatening
indicated (e.g., oral        operative intervention          consequences; urgent
antibiotics)                 indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; severe changes in
                             mental status; self-limited     Life-threatening
                             seizure activity; focal         consequences; urgent
-                            neurologic abnormalities        intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
-                            indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
 -                           indicated                       intervention indicated   Death
Local intervention           Systemic intervention or        Blindness (20/200 or
indicated                    hospitalization indicated       worse)                   -
                        IV antibiotic, antifungal, or
                        antiviral intervention
                        indicated; radiologic,
                        endoscopic, or operative
                        intervention indicated; profuse
Passage of >3 unformed watery diarrhea with signs of
stools per 24 hrs or    hypovolemia; bloody
duration of illness >48 diarrhea; fever; severe               Life-threatening
hrs; moderate           abdominal pain;                       consequences; urgent
abdominal pain          hospitalization indicated             intervention indicated     Death
                        IV antibiotic, antifungal, or
Local intervention      antiviral intervention
indicated (e.g., oral   indicated; radiologic or              Life-threatening
antibiotic, antifungal, operative intervention                consequences; urgent
antiviral)              indicated                             intervention indicated     Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention           Life-threatening
intervention indicated       indicated; radiologic or         consequences; urgent
(e.g., topical antibiotic,   operative intervention           intervention indicated;
antifungal, or antiviral)    indicated                        enucleation                Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic,           Life-threatening
                             endoscopic, or operative         consequences; urgent
 -                           intervention indicated           intervention indicated     Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or         Life-threatening
antibiotic, antifungal,      operative intervention           consequences; urgent
antiviral)                   indicated                        intervention indicated     Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or         Life-threatening
                             operative intervention           consequences; urgent
-                            indicated                        intervention indicated     Death
                             Symptomatic liver dysfunction;
                             fibrosis by biopsy;              Decompensated liver
                             compensated cirrhosis;           function (e.g., ascites,
                             reactivation of chronic          coagulopathy,
-                            hepatitis                        encephalopathy, coma)      Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or         Life-threatening
(e.g., topical antibiotic,   operative intervention           consequences; urgent
antifungal, or antiviral)    indicated                        intervention indicated     Death
Localized; local
intervention indicated;
oral intervention
indicated (e.g.,
antibiotic, antifungal,      Arthroscopic intervention
antiviral); needle           indicated (e.g., drainage) or     Life-threatening
aspiration indicated         arthrotomy (e.g., open surgical   consequences; urgent
(single or multiple)         drainage)                         intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic,            Life-threatening
                             endoscopic, or operative          consequences; urgent
 -                           intervention indicated            intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or          Life-threatening
antibiotic, antifungal,      operative intervention            consequences; urgent
antiviral)                   indicated                         intervention indicated   Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or
antibiotic, antifungal,      operative intervention
antiviral)                   indicated                         -                        -
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,            Life-threatening
antibiotic, antifungal,      endoscopic, or operative          consequences; urgent
antiviral)                   intervention indicated            intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or          Life-threatening
(e.g., topical antibiotic,   operative intervention            consequences; urgent
antifungal, or antiviral)    indicated                         intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or          Life-threatening
                             operative intervention            consequences; urgent
-                            indicated                         intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or
                             operative intervention            Life-threatening
                             indicated; focal neurologic       consequences; urgent
-                            deficit                           intervention indicated   Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or
antibiotic, antifungal,      operative intervention
antiviral)                   indicated                       -                        -

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
-                            indicated                       intervention indicated   Death


                                                      Papules and/or pustules
Papules and/or pustules                               covering any % BSA, which
covering 10-30% BSA,    Papules and/or pustules       may or may not be
which may or may not covering >30% BSA, which may associated with symptoms
be associated with      or may not be associated with of pruritus or tenderness
symptoms of pruritus or symptoms of pruritus or       and are associated with
tenderness; associated tenderness; limiting self-care extensive superinfection
with psychosocial       ADL; associated with local    with IV antibiotics
impact; limiting        superinfection with oral      indicated; life-threatening
instrumental ADL        antibiotics indicated         consequences                Death
Localized intervention
indicated; oral
intervention indicated
(e.g., antibiotic,
antifungal, antiviral);
nail fold edema or
erythema with pain;
associated with
discharge or nail plate      Surgical intervention or IV
separation; limiting         antibiotics indicated; limiting
instrumental ADL             self care ADL                     -                        -
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or          Life-threatening
antibiotic, antifungal,      operative intervention            consequences; urgent
antiviral)                   indicated                         intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or          Life-threatening
(e.g., topical antibiotic,   operative intervention            consequences; urgent
antifungal, or antiviral)    indicated                         intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or          Life-threatening
(e.g., topical antibiotic,   operative intervention            consequences; urgent
antifungal, or antiviral)    indicated                         intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or          Life-threatening
(e.g., topical antibiotic,   operative intervention            consequences; urgent
antifungal, or antiviral)    indicated                         intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic,            Life-threatening
                             endoscopic, or operative          consequences; urgent
-                            intervention indicated            intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or          Life-threatening
(e.g., topical antibiotic,   operative intervention            consequences; urgent
antifungal, or antiviral)    indicated                         intervention indicated   Death
                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic,          Life-threatening
(e.g., topical antibiotic,   endoscopic, or operative        consequences; urgent
antifungal, or antiviral)    intervention indicated          intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,          Life-threatening
antibiotic, antifungal,      endoscopic, or operative        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or
(e.g., topical antibiotic,   operative intervention
antifungal, or antiviral)    indicated                       -                        -


Localized; local
intervention indicated
(e.g., topical antibiotic,
antifungal, or antiviral)     -                              -                        -
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                                                             Life-threatening
                                                             consequences; urgent
-                            -                               intervention indicated   Death
                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic,          Life-threatening
(e.g., topical antibiotic,   endoscopic, or operative        consequences; urgent
antifungal, or antiviral)    intervention indicated          intervention indicated   Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
                             antiviral intervention
                             indicated; radiologic or        Life-threatening
                             operative intervention          consequences; urgent
-                            indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,          Life-threatening
antibiotic, antifungal,      endoscopic, or operative        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,          Life-threatening
antibiotic, antifungal,      endoscopic, or operative        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic,          Life-threatening
antibiotic, antifungal,      endoscopic, or operative        consequences; urgent
antiviral)                   intervention indicated          intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic,          Life-threatening
(e.g., topical antibiotic,   endoscopic, or operative        consequences; urgent
antifungal, or antiviral)    intervention indicated          intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
Moderate symptoms;           IV antibiotic, antifungal, or
oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                             IV antibiotic, antifungal, or
Oral intervention            antiviral intervention
indicated (e.g.,             indicated; radiologic or        Life-threatening
antibiotic, antifungal,      operative intervention          consequences; urgent
antiviral)                   indicated                       intervention indicated   Death

                             IV antibiotic, antifungal, or
Localized; local             antiviral intervention
intervention indicated       indicated; radiologic or        Life-threatening
(e.g., topical antibiotic,   operative intervention          consequences; urgent
antifungal, or antiviral)    indicated                       intervention indicated   Death
                           Severe or medically significant
Moderate; minimal,         but not immediately life-
local or noninvasive       threatening; hospitalization or
intervention indicated;    prolongation of existing          Life-threatening
limiting age-appropriate   hospitalization indicated;        consequences; urgent
instrumental ADL           disabling; limiting self care ADL intervention indicated   Death

Limiting instrumental
ADL; operative             Limiting self care ADL; elective
intervention indicated     surgery indicated                -                         -

                                                          Life-threatening
                                                          consequences; evidence of
                           Severe symptoms; limiting self end organ damage; urgent
                           care ADL; disabling; repair or operative intervention
-                          revision indicated             indicated                 Death

                                                          Life-threatening
                                                          consequences; evidence of
Symptomatic (e.g.,         Severe symptoms; limiting self end organ damage; urgent
claudication); repair or   care ADL; disabling; repair or operative intervention
revision not indicated     revision indicated             indicated                 Death
                           Severe symptoms; radiologic, Life-threatening
                           endoscopic or elective         consequences; urgent
Symptomatic; medical       operative intervention         operative intervention
intervention indicated     indicated                      indicated                 Death
                           Severe symptoms; radiologic, Life-threatening
                           endoscopic or elective         consequences; urgent
Symptomatic; medical       operative intervention         operative intervention
intervention indicated     indicated                      indicated                 Death


Generalized                -                                -                         -

Medical intervention;  Moderate to major
minimal debridement    debridement or reconstruction Life-threatening
indicated              indicated                     consequences              Death
                                                     Life-threatening
Moderate to brisk                                    consequences; skin
erythema; patchy moist                               necrosis or ulceration of
desquamation, mostly Moist desquamation in areas full thickness dermis;
confined to skin folds other than skin folds and     spontaneous bleeding from
and creases; moderate creases; bleeding induced by involved site; skin graft
edema                  minor trauma or abrasion      indicated                 Death
                          Severe symptoms; radiologic,      Life-threatening
                          endoscopic or elective            consequences; urgent
Symptomatic; medical      operative intervention            operative intervention
intervention indicated    indicated                         indicated                Death

Symptomatic;
noninvasive intervention
indicated                Hospitalization indicated           -                       -
                         Severe symptoms; radiologic,       Life-threatening
                         endoscopic or elective             consequences; urgent
Symptomatic; medical operative intervention                 operative intervention
intervention indicated indicated                            indicated                Death
                                                            Life-threatening
                                                            consequences; urgent
Symptomatic and           Severe symptoms; elective         operative intervention
intervention not          operative intervention            indicated (e.g., organ
indicated                 indicated                         resection)               Death

                         Severe symptoms; displaced or
Symptomatic but non- open wound with bone                   Life-threatening
displaced;               exposure; disabling; operative     consequences; urgent
immobilization indicated intervention indicated             intervention indicated   Death
                         Severe symptoms; radiologic,       Life-threatening
                         endoscopic or elective             consequences; urgent
Symptomatic; medical operative intervention                 operative intervention
intervention indicated indicated                            indicated                Death
                         Severe symptoms; radiologic,       Life-threatening
                         endoscopic or elective             consequences; urgent
Symptomatic; medical operative intervention                 operative intervention
intervention indicated indicated                            indicated                Death
                         Severe symptoms;
Superficial necrosis;    hospitalization or elective        Life-threatening
intervention not         operative intervention             consequences; urgent
indicated                indicated                          intervention indicated   Death

Hairline fracture; mild   Severe pain; hospitalization or
pain; limiting            intervention indicated for pain   Life-threatening
instrumental ADL; non-    control (e.g., traction);         consequences; symptoms
surgical intervention     operative intervention            associated with
indicated                 indicated                         neurovascular compromise -

                          Severe symptoms; limiting self
                          care ADL (e.g., transient      Life-threatening
                          cerebral ischemia); repair or  consequences; urgent
-                         revision indicated             intervention indicated      Death
                                                        Life-threatening
                                                        consequences; urgent
-                         -                             intervention indicated    Death
                         Symptomatic limiting self care Life-threatening
                         ADL; disabling; repair or      consequences; urgent
-                        revision indicated             intervention indicated    Death

                                                        Life-threatening
                                                        consequences; evidence of
                         Severe symptoms; limiting self end organ damage; urgent
Symptomatic; repair or   care ADL; disabling; repair or operative intervention
revision not indicated   revision indicated             indicated                 Death
                         Severe symptoms; radiologic, Life-threatening
                         endoscopic or elective         consequences; urgent
Symptomatic; medical     operative intervention         operative intervention
intervention indicated   indicated                      indicated                 Death

                        Severe symptoms; IV fluids,      Life-threatening
Self-limited;           tube feeding, or TPN indicated   consequences; urgent
intervention not        >=24 hrs; elective operative     operative intervention
indicated               intervention indicated           indicated                Death
                        Severe bleeding; transfusion
Moderate bleeding;      indicated; radiologic or         Life-threatening
medical intervention    endoscopic intervention          consequences; urgent
indicated               indicated                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                                                         Life-threatening
                         Primary repair of injured       consequences; urgent
-                        organ/structure indicated       intervention indicated   Death

                        Complete resection of injured
Partial resection of    organ/structure indicated;       Life-threatening
injured organ/structure disabling (e.g., impaired        consequences; urgent
indicated               hearing; impaired balance)       intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Postoperative radiologic,        Life-threatening
                        endoscopic, or operative         consequences; urgent
 -                      intervention indicated           intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured        Life-threatening
injured organ/structure organ/structure indicated;       consequences; urgent
indicated               disabling                        intervention indicated   Death

Primary repair of injured Resection or reconstruction of Life-threatening
organ/structure           injured organ/structure        consequences; urgent
indicated                 indicated; disabling           intervention indicated   Death
                        Complete resection or
Partial resection of    reconstruction of injured            Life-threatening
injured organ/structure organ/structure indicated;           consequences; urgent
indicated               disabling                            intervention indicated    Death
                        Complete resection or
Partial resection of    reconstruction of injured            Life-threatening
injured organ/structure organ/structure indicated;           consequences; urgent
indicated               disabling                            intervention indicated    Death
                        Severe symptoms; radiologic,         Life-threatening
                        endoscopic or elective               consequences; urgent
Symptomatic; medical operative intervention                  operative intervention
intervention indicated indicated                             indicated                 Death
                        Severe symptoms; radiologic,         Life-threatening
                        endoscopic or elective               consequences; urgent
Symptomatic; medical operative intervention                  operative intervention
intervention indicated indicated                             indicated                 Death
                        Severe symptoms; radiologic,         Life-threatening
                        endoscopic or elective               consequences; urgent
Symptomatic; medical operative intervention                  operative intervention
intervention indicated indicated                             indicated                 Death
                        Severe symptoms; radiologic,         Life-threatening
                        endoscopic or elective               consequences; urgent
Symptomatic; medical operative intervention                  operative intervention
intervention indicated indicated                             indicated                 Death
                        Transfusion indicated of >=2
                        units (10 cc/kg for pediatrics)
                        pRBCs beyond protocol
Moderate bleeding;      specification; urgent
radiologic, endoscopic, radiologic, endoscopic, or           Life-threatening
or operative            operative intervention               consequences; urgent
intervention indicated indicated                             intervention indicated    Death

                                                             Life-threatening airway
                         Extubated >72 hrs                   compromise; urgent
Extubated within 24 - 72 postoperatively, but before         intervention indicated (e.g.,
hrs postoperatively      tracheostomy indicated              tracheotomy or intubation) Death

Recurrent after manual
reduction; local
irritation or stool          Severe symptoms; elective       Life-threatening
leakage; difficulty to fit   operative intervention          consequences; urgent
appliance; limiting          indicated; limiting self care   operative intervention
instrumental ADL             ADL                             indicated                 Death
                             Dysfunctional stoma; elective
Local care or                operative intervention or       Life-threatening
maintenance; minor           major stomal revision           consequences; urgent
revision indicated           indicated                       intervention indicated    Death
                                                              Life-threatening
Moderate to brisk                                             consequences; skin
erythema; patchy moist                                        necrosis or ulceration of
desquamation, mostly      Moist desquamation in areas         full thickness dermis;
confined to skin folds    other than skin folds and           spontaneous bleeding from
and creases; moderate     creases; bleeding induced by        involved site; skin graft
edema                     minor trauma or abrasion            indicated                 Death
                          Severe symptoms; radiologic,        Life-threatening
                          endoscopic or elective              consequences; urgent
Symptomatic; medical      operative intervention              operative intervention
intervention indicated    indicated                           indicated                 Death

                          Symptomatic, elective
Symptomatic; simple       radiologic or operative
aspiration indicated      intervention indicated               -                        -
                          Severe symptoms; radiologic,        Life-threatening
                          endoscopic or elective              consequences; urgent
Symptomatic; medical      operative intervention              operative intervention
intervention indicated    indicated                           indicated                Death
                          Severe symptoms; radiologic,        Life-threatening
                          endoscopic or elective              consequences; urgent
Symptomatic; medical      operative intervention              operative intervention
intervention indicated    indicated                           indicated                Death

                          Severe back pain;
Moderate back pain;       hospitalization or intervention     Life-threatening
prescription analgesics   indicated for pain control (e.g.,   consequences; symptoms
indicated; limiting       vertebroplasty); limiting self      associated with
instrumental ADL          care ADL; disability                neurovascular compromise Death

                          Severely altered GI function;
Symptomatic; IV fluids    tube feeding, TPN or                Life-threatening
indicated <24 hrs;        hospitalization indicated;          consequences; urgent
manual dilation at        elective operative intervention     operative intervention
bedside                   indicated                           indicated                Death

                          Severe symptoms; elective
Symptomatic; medical      operative intervention
intervention indicated    indicated                           -                         -

                          Severe bleeding; transfusion
Moderate bleeding;        indicated; radiologic or            Life-threatening
medical intervention      endoscopic intervention             consequences; urgent
indicated                 indicated                           intervention indicated   Death
Symptomatic (e.g., noisy
airway breathing), no
respiratory distress;
medical intervention          Stridor; radiologic or            Life-threatening airway
indicated (e.g., steroids);   endoscopic intervention           compromise; urgent
limiting instrumental         indicated (e.g., stent, laser);   intervention indicated (e.g.,
ADL                           limiting self care ADL            tracheotomy or intubation) Death
                              Severe bleeding; transfusion
Moderate bleeding;            indicated; radiologic or          Life-threatening
medical intervention          endoscopic intervention           consequences; urgent
indicated                     indicated                         intervention indicated      Death
                              Severe symptoms; radiologic,      Life-threatening
                              endoscopic or elective            consequences; urgent
Symptomatic; medical          operative intervention            operative intervention
intervention indicated        indicated                         indicated                   Death
                              Severe symptoms; radiologic,      Life-threatening
                              endoscopic or elective            consequences; urgent
Symptomatic; medical          operative intervention            operative intervention
intervention indicated        indicated                         indicated                   Death
                              Severe symptoms; radiologic,      Life-threatening
                              endoscopic or elective            consequences; urgent
Symptomatic; medical          operative intervention            operative intervention
intervention indicated        indicated                         indicated                   Death

                              Altered organ function (e.g.,
Symptomatic; dilation or      sepsis or hydronephrosis, or      Life-threatening
endoscopic repair or          renal dysfunction); elective      consequences; organ
stent placement               operative intervention            failure; urgent operative
indicated                     indicated                         intervention indicated      Death
                              Severe bleeding; transfusion
Moderate bleeding;            indicated; radiologic or          Life-threatening
medical intervention          endoscopic intervention           consequences; urgent
indicated                     indicated                         intervention indicated      Death
Symptomatic but no
hydronephrosis, no
sepsis or no renal            Symptomatic (e.g.,
dysfunction; dilation or      hydronephrosis, or renal          Life-threatening
endoscopic repair or          dysfunction); elective            consequences; urgent
stent placement               operative intervention            operative intervention
indicated                     indicated                         indicated                   Death
                              Severe symptoms; radiologic,      Life-threatening
                              endoscopic or elective            consequences; urgent
Symptomatic; medical          operative intervention            operative intervention
intervention indicated        indicated                         indicated                   Death
Symptomatic and            Severe symptoms; elective         Life-threatening
intervention not           operative intervention            consequences; urgent
indicated                  indicated                         intervention indicated       Death
                           Severe symptoms; radiologic,      Life-threatening
                           endoscopic or elective            consequences; urgent
Symptomatic; medical       operative intervention            operative intervention
intervention indicated     indicated                         indicated                    Death
                           Severe symptoms; radiologic,      Life-threatening
                           endoscopic or elective            consequences; urgent
Symptomatic; medical       operative intervention            operative intervention
intervention indicated     indicated                         indicated                    Death

                           Deep vein or cardiac
Device dislodgement,       thrombosis; intervention
blockage, leak, or         indicated (e.g.,                  Embolic event including
malposition; device        anticoagulation, lysis, filter,   pulmonary embolism or life-
replacement indicated      invasive procedure)               threatening thrombus        Death

                                                          Life-threatening
                                                          consequences; evidence of
Symptomatic (e.g.,         Severe symptoms; limiting self end organ damage; urgent
claudication); repair or   care ADL; repair or revision   operative intervention
revision not indicated     indicated; disabling           indicated                 Death
                           Hernia without evidence of
                           strangulation; fascial         Hernia with evidence of
                           disruption/dehiscence;         strangulation; major
Incisional separation      primary wound closure or       reconstruction flap,
>25% of wound; local       revision by operative          grafting, resection, or
care indicated             intervention indicated         amputation indicated      Death

                                                             Life-threatening
                                                             consequences;
Incisional separation                                        symptomatic hernia with
>25% of wound with         Fascial disruption or             evidence of strangulation;
local care;                dehiscence without                fascial disruption with
asymptomatic hernia or     evisceration; primary wound       evisceration; major
symptomatic hernia         closure or revision by            reconstruction flap,
without evidence of        operative intervention            grafting, resection, or
strangulation              indicated                         amputation indicated         Death

Limiting instrumental
ADL; operative             Limiting self care ADL; elective
intervention indicated     surgery indicated                -                             -
                           Severe or medically significant
Moderate; minimal,         but not immediately life-
local or noninvasive       threatening; hospitalization or
intervention indicated;    prolongation of existing          Life-threatening
limiting age-appropriate   hospitalization indicated;        consequences; urgent
instrumental ADL           disabling; limiting self care ADL intervention indicated   Death




>1.5 - 2.5 x ULN           >2.5 x ULN; hemorrhage           -                         -

Asymptomatic with ALT
>3.0 - 5.0 x ULN; >3 x
ULN with the
appearance of
worsening of fatigue,
nausea, vomiting, right
upper quadrant pain or
tenderness, fever, rash, >5.0 - 20.0 x ULN; >5 x ULN for
or eosinophilia          >2 weeks                        >20.0 x ULN                  -

>2.5 - 5.0 x ULN           >5.0 - 20.0 x ULN                >20.0 x ULN               -

Asymptomatic with AST
>3.0 - 5.0 x ULN; >3 x
ULN with the
appearance of
worsening of fatigue,
nausea, vomiting, right
upper quadrant pain or
tenderness, fever, rash, >5.0 - 20.0 x ULN; >5 x ULN for
or eosinophilia          >2 weeks                        >20.0 x ULN                  -


Symptomatic; medical
intervention indicated     Hospitalization indicated        -                         -

>1.5 - 3.0 x ULN           >3.0 - 10.0 x ULN                >10.0 x ULN               -


Symptomatic; medical
intervention indicated     Hospitalization indicated        -                         -
Symptomatic; medical
intervention indicated;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                            -

Moderate symptoms;
limiting instrumental
ADL                        -                               -                          -

6 - 8 units below LLN;    Asymptomatic decrease of >8
for follow-up, an         units drop; >5 units drop
asymptomatic decrease     along with the presence of
of >5 - 8 units           pulmonary symptoms (e.g. ,
(ml/sec/mm Hg) below      >Grade 2 hypoxia or >Grade 2
the baseline value        or higher dyspnea)           -                              -


                          Levels consistent with
                          myocardial infarction as
-                         defined by the manufacturer      -                          -


                        Levels consistent with
                        myocardial infarction as
 -                      defined by the manufacturer        -                          -
<500 - 200/mm3; <0.5 - <200 - 50/mm3; <0.2 x 0.05 -
0.2 x 10e9 /L           10e9 /L                            <50/mm3; <0.05 x 10e9 /L   -
>300 - 400 mg/dL; >7.75 >400 - 500 mg/dL; >10.34 -         >500 mg/dL; >12.92
- 10.34 mmol/L          12.92 mmol/L                       mmol/L                     -

>2.5 x ULN - 5 x ULN      >5 x ULN - 10 x ULN              >10 x ULN                  -
>1.5 - 3.0 x baseline;
>1.5 - 3.0 x ULN          >3.0 baseline; >3.0 - 6.0 x ULN >6.0 x ULN                  -

Resting ejection fraction Resting ejection fraction (EF)
(EF) 50 - 40%; 10 - 19% 39 - 20%; >20% drop from        Resting ejection fraction
drop from baseline        baseline                      (EF) <20%                     -
                                                        QTc >= 501 or >60 ms
                                                        change from baseline and
                                                        Torsade de pointes or
                                                        polymorphic ventricular
                                                        tachycardia or
                          QTc >= 501 ms on at least two signs/symptoms of serious
QTc 481 - 500 ms          separate ECGs                 arrhythmia                    -
<0.75 - 0.5 x LLN or 25 -                                <0.25 x LLN or 75%
<50% decrease from        <0.5 - 0.25 x LLN or 50 - <75% decrease from baseline or
baseline                  decrease from baseline         absolute value <50 mg/dL    -




FEV1 60 - 69%               50 - 59%                      <= 49%                     -




>2.5 - 5.0 x ULN            >5.0 - 20.0 x ULN             >20.0 x ULN                -
Symptomatic; medical
intervention indicated;
limiting instrumental
ADL                         -                             -                          -

-                           -                             -                          -

Increase in >2 - 4 gm/dL
above ULN or above       Increase in >4 gm/dL above
baseline if baseline is  ULN or above baseline if
above ULN                baseline is above ULN            -                          -

>1.5 - 2.5 x ULN; >1.5 -
2.5 times above baseline >2.5 x ULN; >2.5 times above
if on anticoagulation    baseline if on anticoagulation   -                          -

>1.5 - 2.0 x ULN       >2.0 - 5.0 x ULN                   >5.0 x ULN                 -
<800 - 500/mm3; <0.8 - <500 - 200/mm3; <0.5 - 0.2 x
0.5 x 10e9 /L          10e9 /L                            <200/mm3; <0.2 x 10e9 /L   -

>4000/mm3 -
20,000/mm3                  >20,000/mm3                   -                          -
<1500 - 1000/mm3;           <1000 - 500/mm3; <1.0 - 0.5 x
<1.5 - 1.0 x 10e9 /L        10e9 /L                       <500/mm3; <0.5 x 10e9 /L   -
Increase in stool
frequency, bulk, or odor;   Sequelae of absorption
steatorrhea                 deficiency                    -                          -

<75,000 - 50,000/mm3; <50,000 - 25,000/mm3; <50.0 - <25,000/mm3; <25.0 x
<75.0 - 50.0 x 10e9 /L 25.0 x 10e9 /L               10e9 /L                          -

>1.5 - 2.0 x ULN            >2.0 - 5.0 x ULN              >5.0 x ULN                 -
-                          Oliguria (<80 ml in 8 hr)        Anuria (<240 ml in 24 hr)   -

<75 - 50% of predicted
value; limiting            <50% of predicted value;
instrumental ADL           limiting self care ADL           -                           -


10 - <20% from baseline    >=20% from baseline              -                           -
10 - <20% from baseline;
nutritional support        >=20% from baseline; tube
indicated                  feeding or TPN indicated      -                              -
<3000 - 2000/mm3;          <2000 - 1000/mm3; <2.0 - 1.0 <1000/mm3; <1.0 x 10e9
<3.0 - 2.0 x 10e9 /L       x 10e9 /L                    /L                              -




                           Severe or medically significant
Moderate; minimal,         but not immediately life-
local or noninvasive       threatening; hospitalization or
intervention indicated;    prolongation of existing          Life-threatening
limiting age-appropriate   hospitalization indicated;        consequences; urgent
instrumental ADL           disabling; limiting self care ADL intervention indicated     Death
                                                             Life-threatening
-                          pH <7.3                           consequences               Death
                                                             Life-threatening
                           Severe symptoms; limiting self consequences; urgent
Present                    care ADL                          intervention indicated     Death
                                                             Life-threatening
                           pH >7.5                           consequences               Death

Oral intake altered
without significant        Associated with significant
weight loss or             weight loss or malnutrition
malnutrition; oral         (e.g., inadequate oral caloric   Life-threatening
nutritional supplements    and/or fluid intake); tube       consequences; urgent
indicated                  feeding or TPN indicated         intervention indicated      Death

                                                            Life-threatening
IV fluids indicated <24    IV fluids or hospitalization     consequences; urgent
hrs                        indicated                        intervention indicated      Death

Symptomatic; dietary                                        Life-threatening
modification or oral       Severe symptoms; insulin         consequences; urgent
agent indicated            indicated                        intervention indicated      Death
>11.5 - 12.5 mg/dL; >2.9   >12.5 - 13.5 mg/dL;>3.1 - 3.4 >13.5 mg/dL; >3.4 mmol/L;
- 3.1 mmol/L; Ionized      mmol/L; Ionized calcium >1.6 - Ionized calcium >1.8
calcium >1.5 - 1.6         1.8 mmol/L; hospitalization    mmol/L; life-threatening
mmol/L; symptomatic        indicated                      consequences             Death
Fasting glucose value
>160 - 250 mg/dL;          >250 - 500 mg/dL; >13.9 - 27.8 >500 mg/dL; >27.8
Fasting glucose value      mmol/L; hospitalization        mmol/L; life-threatening
>8.9 - 13.9 mmol/L         indicated                      consequences                 Death

                           >6.0 - 7.0 mmol/L;               >7.0 mmol/L; life-
>5.5 - 6.0 mmol/L          hospitalization indicated        threatening consequences Death

                                                            >8.0 mg/dL; >3.30 mmol/L;
                           >3.0 - 8.0 mg/dL; >1.23 - 3.30   life-threatening
-                          mmol/L                           consequences              Death

                           >155 - 160 mmol/L;               >160 mmol/L; life-
>150 - 155 mmol/L          hospitalization indicated        threatening consequences Death

>300 mg/dL - 500                                            >1000 mg/dL; >11.4
mg/dL; >3.42 mmol/L - >500 mg/dL - 1000 mg/dL;              mmol/L; life-threatening
5.7 mmol/L            >5.7 mmol/L - 11.4 mmol/L             consequences               Death

                           >ULN - 10 mg/dL; <=0.59          >10 mg/dL; >0.59 mmol/L;
                           mmol/L with physiologic          life-threatening
-                          consequences                     consequences             Death
                                                            Life-threatening
                                                            consequences; urgent
<3 - 2 g/dL; <30 - 20 g/L <2 g/dL; <20 g/L                  intervention indicated   Death

<8.0 - 7.0 mg/dL; <2.0 -   <7.0 - 6.0 mg/dL; <1.75 - 1.5  <6.0 mg/dL; <1.5 mmol/L;
1.75 mmol/L; Ionized       mmol/L; Ionized calcium <0.9 - Ionized calcium <0.8
calcium <1.0 - 0.9         0.8 mmol/L; hospitalization    mmol/L; life-threatening
mmol/L; symptomatic        indicated                      consequences                 Death

                                                            <30 mg/dL; <1.7 mmol/L;
<55 - 40 mg/dL; <3.0 -     <40 - 30 mg/dL; <2.2 - 1.7       life-threatening
2.2 mmol/L                 mmol/L                           consequences; seizures     Death

<LLN - 3.0 mmol/L;
symptomatic;               <3.0 - 2.5 mmol/L;               <2.5 mmol/L; life-
intervention indicated     hospitalization indicated        threatening consequences Death

                                                            <0.7 mg/dL; <0.3 mmol/L;
<1.2 - 0.9 mg/dL; <0.5 -   <0.9 - 0.7 mg/dL; <0.4 - 0.3     life-threatening
0.4 mmol/L                 mmol/L                           consequences               Death
                                                             <120 mmol/L; life-
-                          <130 - 120 mmol/L                 threatening consequences Death

                                                             <1.0 mg/dL; <0.3 mmol/L;
<2.5 - 2.0 mg/dL; <0.8 -   <2.0 - 1.0 mg/dL; <0.6 - 0.3      life-threatening
0.6 mmol/L                 mmol/L                            consequences               Death
Moderate symptoms;                                           Life-threatening
intervention not           Severe symptoms;                  consequences; urgent
indicated                  intervention indicated            intervention indicated     Death

BMI 25 - 29.9 kg/m2        BMI 30 - 39.9 kg/m2               BMI >=40 kg/m2
                                                             Life-threatening
                                                             consequences; urgent
-                          Present                           intervention indicated     Death


                           Severe or medically significant
                           but not immediately life-
Moderate; minimal,         threatening; hospitalization or
local or noninvasive       prolongation of existing
intervention indicated; hospitalization indicated;           Life-threatening
limiting age-appropriate disabling; limiting self care       consequences; urgent
instrumental ADL           ADL                               intervention indicated     Death
                           Operative debridement or
Local wound care;          other invasive intervention
medical intervention       indicated (e.g. tissue            Life-threatening
indicated (e.g., dressings reconstruction, flap or           consequences; urgent
or topical medications) grafting)                            intervention indicated     Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                  -                          -

Moderate pain
associated with signs of   Severe pain associated with
inflammation,              signs of inflammation,
erythema, or joint         erythema, or joint swelling;
swelling; limiting         irreversible joint damage;
instrumental ADL           disabling; limiting self care ADL -                          -

                           Severe symptoms; limiting self Life-threatening
Symptomatic; limiting      care ADL; elective operative   consequences; urgent
instrumental ADL           intervention indicated         intervention indicated        Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                  -                          -
Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                     -                         -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                     -                         -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                     -                         -

                             Severe symptoms; limiting self
Symptomatic; limiting        care ADL; elective operative
instrumental ADL             intervention indicated         -                             -

                             Severe induration; unable to
Moderate induration,         slide or pinch skin; limiting      Generalized; associated
able to slide skin, unable   joint or orifice movement (e.g.    with signs or symptoms of
to pinch skin; limiting      mouth, anus); limiting self care   impaired breathing or
instrumental ADL             ADL                                feeding                   Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                     -                         -

Symptomatic; weakness
evident on physical
exam; weakness limiting Weakness limiting self care
instrumental ADL        ADL; disabling                          -                         -

Reduction in growth
velocity by 30 - 49%
ideally measured over
the period of a year or 0 -
49% reduction in growth Reduction in growth velocity
from the baseline           of >=50% ideally measured
growth curve                over the period of a year           -                         -

                             Operative debridement or
Local wound care;            other invasive intervention
medical intervention         indicated (e.g., tissue            Life-threatening
indicated (e.g., dressings   reconstruction, flap or            consequences; urgent
or topical medications)      grafting)                          intervention indicated   Death
                             Severe symptoms; limiting self
                             care ADL; elective operative
Symptomatic; limiting        intervention indicated;
instrumental ADL             disabling                          -                         -
>25 - 50% decrease in
ROM; limiting                >50% decrease in ROM;
instrumental ADL             limiting self care ADL; disabling   -   -
Rotation <60 degrees to      Ankylosed/fused over multiple
right or left; <60 degrees   segments with no C-spine
of flexion                   rotation                            -   -
                             <50% lumbar spine flexion;
Pain with range of           associated with symptoms of
motion (ROM) in lumbar       ankylosis or fused over
spine; requires a            multiple segments with no L-
reaching aid to pick up a    spine flexion (e.g., unable to
very light object from       reach to floor to pick up a very
the floor                    light object)                       -   -
                             Severe accentuation;
Moderate accentuation;       operative intervention
limiting instrumental        indicated; limiting self care
ADL                          ADL                                 -   -
                             Severe accentuation;
Moderate accentuation;       operative intervention
limiting instrumental        indicated; limiting self care
ADL                          ADL                                 -   -
Symptomatic; evident
on physical exam;
limiting instrumental        Limiting self care ADL;
ADL                          disabling                           -   -
Symptomatic; evident
on physical exam;
limiting instrumental        Limiting self care ADL;
ADL                          disabling                           -   -
Symptomatic; evident
on physical exam;
limiting instrumental        Limiting self care ADL;
ADL                          disabling                           -   -
Symptomatic; evident
on physical exam;
limiting instrumental        Limiting self care ADL;
ADL                          disabling                           -   -
Symptomatic; evident
on physical exam;
limiting instrumental        Limiting self care ADL;
ADL                          disabling                           -   -
Deformity, hypoplasia,
or asymmetry able to be      Significant deformity,
remediated by                hypoplasia, or asymmetry,
prosthesis (e.g., shoe       unable to be remediated by
insert) or covered by        prosthesis or covered by
clothing                     clothing; disabling            -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                        -

Moderate pain
associated with         Pain associated with severe
weakness; pain limiting weakness; limiting self care
instrumental ADL        ADL                                 -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                        -

                             Operative debridement or
Local wound care;            other invasive intervention
medical intervention         indicated (e.g., tissue        Life-threatening
indicated (e.g., dressings   reconstruction, flap or        consequences; urgent
or topical medications)      grafting)                      intervention indicated   Death

Symptomatic; medical
intervention indicated
(e.g., topical agents);      Severe symptoms; limiting self Life-threatening
limiting instrumental        care ADL; elective operative   consequences; urgent
ADL                          intervention indicated         intervention indicated   Death


BMD t-score <-2.5; loss
of height <2 cm; anti-
osteoporotic therapy         Loss of height >=2 cm;
indicated; limiting          hospitalization indicated;
instrumental ADL             limiting self care ADL         -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                        -

                             Operative debridement or
Local wound care;            other invasive intervention
medical intervention         indicated (e.g., tissue        Life-threatening
indicated (e.g., dressings   reconstruction, flap or        consequences; urgent
or topical medications)      grafting)                      intervention indicated   Death
                          >45 degrees; scapular
>20 - 45 degrees; visible prominence in forward flexion;
by forward flexion;       operative intervention
limiting instrumental     indicated; limiting self care
ADL                       ADL; disabling                 -                             -

                           Operative debridement or
Local wound care;          other invasive intervention
medical intervention       indicated (e.g., tissue           Life-threatening
indicated (e.g., dressings reconstruction, flap or           consequences; urgent
or topical medications) grafting)                            intervention indicated   Death

                           Operative debridement or
Local wound care;          other invasive intervention
medical intervention       indicated (e.g., tissue           Life-threatening
indicated (e.g., dressings reconstruction, flap or           consequences; urgent
or topical medications) grafting)                            intervention indicated   Death

                             Severe induration; unable to
Moderate induration,         slide or pinch skin; limiting   Generalized; associated
able to slide skin, unable   joint or orifice movement       with signs or symptoms of
to pinch skin; limiting      (e.g., mouth, anus); limiting   impaired breathing or
instrumental ADL             self care ADL                   feeding                   Death
Decreased ROM                Decreased ROM with inability
requiring small bites,       to adequately aliment or
soft foods or purees         hydrate orally                  -                         -
Moderate length
discrepancy 2 - 5 cm;        Severe length discrepancy >5
shoe lift indicated;         cm; limiting self care ADL;
limiting instrumental        disabling; operative
ADL                          intervention indicated          -                         -


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated       Death




-                            -                               Present                  Death
                                                          Life-threatening
                                                          consequences; urgent
-                         -                               intervention indicated   Death

                                                        Acute life-threatening
                         Non life-threatening secondary secondary malignancy;
-                        malignancy                     blast crisis in leukemia   Death


Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated    Death

Moderate symptoms;
limiting instrumental    Severe symptoms; limiting self
ADL                      care ADL                       -                          -

Moderate symptoms;
limiting instrumental    Severe symptoms; limiting self
ADL                      care ADL                       -                          -

Moderate symptoms;
limiting instrumental    Severe symptoms; limiting self
ADL                      care ADL                       -                          -

Moderate restlessness
or increased motor       Severe restlessness or
activity; limiting       increased motor activity;
instrumental ADL         limiting self care ADL           -                        -
Moderate; short term
memory loss; limiting    Severe; long term memory
instrumental ADL         loss; limiting self care ADL     -                        -

 -                       Voicelessness; unable to speak -                          -
Moderate symptoms;                                      Life-threatening
limiting instrumental    Severe symptoms; limiting self consequences; urgent
ADL                      care ADL                       intervention indicated     Death
Moderate symptoms;        Severe symptoms; limiting self
limiting instrumental     care ADL; mechanical
ADL                       assistance indicated           -                        -

Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                        -

                                                         Life-threatening
Moderate symptoms;        Severe symptoms; medical       consequences; urgent
corticosteroids indicated intervention indicated         intervention indicated   Death

Post-craniotomy:
moderate symptoms;
medical intervention
indicated; Post-lumbar
puncture: persistent                                     Life-threatening
moderate symptoms;        Severe symptoms; medical       consequences; urgent
blood patch indicated     intervention indicated         intervention indicated   Death


Moderate cognitive
disability; interfering
with work/school/life
performance but
capable of independent
living; specialized     Severe cognitive disability;
resources on part time significant impairment of
basis indicated         work/school/life performance -                            -


Moderate impairment in
attention or decreased    Severe impairment in
level of concentration;   attention or decreased level of
limiting instrumental     concentration; limiting self
ADL                       care ADL                        -                       -

Sedation; slow response
to stimuli; limiting                                     Life-threatening
instrumental ADL        Difficult to arouse              consequences             Death

Moderate unsteadiness
or sensation of       Severe unsteadiness or
movement; limiting    sensation of movement;
instrumental ADL      limiting self care ADL              -                       -
Moderate impairment
of articulation or slurred   Severe impairment of
speech                       articulation or slurred speech   -                        -
Moderate sensory
alteration; limiting         Severe sensory alteration;
instrumental ADL             limiting self care ADL           -                        -

Altered taste with
change in diet (e.g., oral
supplements); noxious
or unpleasant taste; loss
of taste                     -                                -                        -
Moderate receptive or
expressive
characteristics;             Severe receptive or expressive
impairing ability to         characteristics; impairing
communicate                  ability to read, write or
spontaneously                communicate intelligibly        -                         -
                                                            Life-threatening
                                                            consequences; urgent
 -                            -                             intervention indicated
Moderate symptoms;                                          Life-threatening
limiting instrumental        Severe symptoms; limiting self consequences; urgent
ADL                          care ADL                       intervention indicated     Death

Moderate involuntary         Severe involuntary               Life-threatening
movements; limiting          movements or torticollis;        consequences; urgent
instrumental ADL             limiting self care ADL           intervention indicated   Death

Moderate symptoms;
limiting instrumental        Severe symptoms; limiting self
ADL                          care ADL                       -                          -

Moderate symptoms;
limiting instrumental        Severe symptoms; limiting self
ADL                          care ADL                       -                          -

Moderate symptoms;                                          Life-threatening
limiting instrumental        Severe symptoms; limiting self consequences; urgent
ADL                          care ADL                       intervention indicated     Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                   -                        -
Moderate symptoms;          Severe symptoms or                Life-threatening
intervention not            neurological deficit;             consequences; urgent
indicated                   intervention indicated            intervention indicated    Death
Moderate increased          Severe increased need for
need for sleep              sleep                             -                         -

Moderate symptoms;
limiting instrumental       Severe symptoms; limiting self
ADL                         care ADL                       -                            -

                            Ventriculostomy, ICP
Moderate symptoms;          monitoring, intraventricular      Life-threatening
medical intervention        thrombolysis, or operative        consequences; urgent
indicated                   intervention indicated            intervention indicated    Death




Moderate symptoms           -                                 -                         -

Moderate symptoms;
limiting instrumental       Severe symptoms; limiting self
ADL                         care ADL                       -                            -
Moderate symptoms;
limiting instrumental
ADL                         -                                 -                         -


Moderate symptoms;
focal T2/FLAIR
hyperintensities,                                             Life-threatening
involving periventricular   Severe symptoms; extensive        consequences; extensive
white matter extending      T2/FLAIR hyperintensities,        T2/FLAIR hyperintensities,
into centrum semiovale      involving periventricular white   involving periventricular
or involving 1/3 to 2/3     matter involving 2/3 or more      white matter involving
of susceptible areas of     of susceptible areas of           most of susceptible areas
cerebrum +/- moderate       cerebrum +/- moderate to          of cerebrum +/- moderate
increase in SAS and/or      severe increase in SAS and/or     to severe increase in SAS
moderate                    moderate to severe                and/or moderate to severe
ventriculomegaly            ventriculomegaly                  ventriculomegaly           Death
Moderate memory
impairment; limiting        Severe memory impairment;
instrumental ADL            limiting self care ADL          -                           -
Moderate symptoms;                                         Life-threatening
limiting instrumental       Severe symptoms; limiting self consequences; urgent
ADL                         care ADL                       intervention indicated       Death
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                           -

Moderate weakness or                                        Life-threatening
sensory loss; limiting    Severe weakness or sensory        consequences; urgent
instrumental ADL          loss; limiting self care ADL      intervention indicated   Death

Moderate pain; limiting   Severe pain; limiting self care
instrumental ADL          ADL                               -                        -
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                           -

Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                           -
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                           -
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                           -

Moderate symptoms;        Severe symptoms; limiting self Life-threatening
limiting instrumental     care ADL; assistive device     consequences; urgent
ADL                       indicated                      intervention indicated      Death
Moderate symptoms;                                       Life-threatening
limiting instrumental     Severe symptoms; limiting self consequences; urgent
ADL                       care ADL                       intervention indicated      Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                        -
Present (e.g., near
fainting)               -                                   -                        -

Moderate symptoms;                                       Life-threatening
limiting instrumental     Severe symptoms; limiting self consequences; urgent
ADL                       care ADL                       intervention indicated      Death

Moderate symptoms;
limiting instrumental                                    Life-threatening
ADL; medical              Severe symptoms; limiting self consequences; urgent
intervention indicated    care ADL                       intervention indicated      Death
                          Severe symptoms; medical
                          intervention indicated (e.g.,    Life-threatening
                          thyroplasty, vocal cord          consequences; urgent
Moderate symptoms         injection)                       intervention indicated     Death
Moderate symptoms;
abnormal imaging          Severe symptoms; very            Life-threatening
studies; limiting         abnormal imaging studies;        consequences; urgent
instrumental ADL          limiting self care ADL           intervention indicated     Death

                          Multiple seizures despite        Life-threatening; prolonged
Brief generalized seizure medical intervention             repetitive seizures         Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                         -
Moderate sedation;                                         Life-threatening
limiting instrumental                                      consequences; urgent
ADL                     Obtundation or stupor              intervention indicated     Death

Moderate increase in
muscle tone and         Severe increase in muscle tone Life-threatening; unable to
increase in resistance  and increase in resistance     move active or passive
through range of motion through range of motion        range of motion             Death
                                                       Life-threatening
Moderate neurologic                                    consequences; urgent
deficit                 Severe neurologic deficit      intervention indicated      Death

-                         Fainting; orthostatic collapse   -                          -

Moderate neurologic
deficit with or without
imaging confirmation      -                                -                          -
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                            -

Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                       -                            -

Moderate symptoms;                                       Life-threatening
limiting instrumental     Severe symptoms; limiting self consequences; urgent
ADL                       care ADL                       intervention indicated       Death
                                                           Life-threatening
                                                           consequences; urgent
-                         Present                          intervention indicated     Death
                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated        Death
                                                                                       Fetal loss at
                                                                                       any
                                                                                       gestational
 -                         -                               -                           age
<10% percentile of
weight for gestational     <5% percentile of weight for     <1% percentile of weight
age                        gestational age                  for gestational age        -
Delivery of a liveborn                                      Delivery of a liveborn
infant at >28 to 34        Delivery of a liveborn infant at infant at 24 weeks of
weeks gestation            24 to 28 weeks gestation         gestation or less          -


-                          Unintended pregnancy            -                           -


                         Severe or medically significant
                         but not immediately life-
                         threatening; hospitalization or
Moderate, local or       prolongation of existing
noninvasive intervention hospitalization indicated;      Life-threatening
indicated; limiting      disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated        Death
                                                         Life-threatening
Moderate mood            Severe agitation;               consequences; urgent
alteration               hospitalization not indicated intervention indicated          Death
Inability to achieve
orgasm adversely
affecting relationship    -                               -                            -

Moderate symptoms;         Severe symptoms; limiting self
limiting instrumental      care ADL; hospitalization not Life-threatening;
ADL                        indicated                      hospitalization indicated    Death

Moderate                                                   Life-threatening
disorientation; limiting   Severe disorientation; limiting consequences; urgent
instrumental ADL           self care ADL                   intervention indicated      Death
Delay in achieving
orgasm adversely
affecting relationship    -                               -                           -

Moderate and acute                                        Life-threatening
confusional state;       Severe and acute confusional     consequences, threats of
limiting instrumental    state; limiting self care ADL;   harm to self or others;
ADL                      hospitalization indicated        hospitalization indicated   Death

                                                          Life-threatening
                                                          consequences, threats of
Moderate delusional      Severe delusional symptoms;      harm to self or others;
symptoms                 hospitalization not indicated    hospitalization indicated   Death

                                                       Life-threatening
Moderate depressive      Severe depressive symptoms; consequences, threats of
symptoms; limiting       limiting self care ADL;       harm to self or others;
instrumental ADL         hospitalization not indicated hospitalization indicated      Death
Moderate mood            Severe mood elevation (e.g.,
elevation                hypomania)                     -                             -

                                                          Life-threatening
                                                          consequences, threats of
                        Severe hallucinations;            harm to self or others;
Moderate hallucinations hospitalization not indicated     hospitalization indicated   Death
Moderate difficulty
falling asleep, staying Severe difficulty in falling
asleep or waking up     asleep, staying asleep or
early                   waking up early                   -                           -
Decrease in sexual
interest adversely
affecting relationship  -                                 -                           -

Moderate increase in      Severe increase in sexual
sexual interest adversely interest leading to dangerous
affecting relationship    behavior                        -                           -

Moderate manic
symptoms (e.g.,          Severe manic symptoms (e.g.,     Life-threatening
relationship and work    hypomania; major sexual or       consequences, threats of
difficulties; poor       financial indiscretions);        harm to self or others;
hygiene)                 hospitalization not indicated    hospitalization indicated   Death

                                                          Life-threatening
                                                          consequences, threats of
Moderate personality     Severe personality change;       harm to self or others;
change                   hospitalization not indicated    hospitalization indicated   Death
Moderate psychotic          Severe psychotic symptoms          Life-threatening
symptoms (e.g.,             (e.g., paranoid; extreme           consequences, threats of
disorganized speech;        disorganization);                  harm to self or others;
impaired reality testing)   hospitalization not indicated      hospitalization indicated     Death
Moderate symptoms;
limiting instrumental     Severe symptoms; limiting self
ADL                       care ADL                              -                            -
                          Specific plan to commit suicide      Specific plan to commit
                          without serious intent to die        suicide with serious intent
Suicidal ideation with no which may not require                to die which requires
specific plan or intent   hospitalization                      hospitalization               -
                          Suicide attempt or gesture
                          without intent to die which          Suicide attempt with intent
                          may not require                      to die which requires
 -                        hospitalization                      hospitalization             Death

Moderate; minimal,
local or noninvasive        Severe or medically significant    Life-threatening
intervention indicated;     but not immediately life-          consequences;
limiting age-appropriate    threatening; disabling; limiting   hospitalization or urgent
instrumental ADL            self care ADL                      intervention indicated        Death
                         Creatinine >3 x baseline or           Life-threatening
Creatinine 2 - 3 x above >4.0 mg/dL; hospitalization           consequences; dialysis
baseline                 indicated                             indicated                     Death

                            Intraperitoneal perforation;       Life-threatening
Extraperitoneal             elective radiologic, endoscopic    consequences; organ
perforation, indwelling     or operative intervention          failure; urgent operative
catheter indicated          indicated                          intervention indicated        Death
Antispasmodics
indicated                   Hospitalization indicated          -                             -




                                                               eGFR or CrCl <15
eGFR or CrCl 59 - 30        eGFR or CrCl 29 - 15               ml/min/1.73 m2; dialysis or
ml/min/1.73 m2              ml/min/1.73 m2                     renal transplant indicated Death
Moderate hematuria;
moderate increase in
frequency, urgency,
dysuria, nocturia or         Gross hematuria; transfusion,
incontinence; urinary        IV medications or
catheter placement or        hospitalization indicated;        Life-threatening
bladder irrigation           elective endoscopic, radiologic   consequences; urgent
indicated; limiting          or operative intervention         radiologic or operative
instrumental ADL             indicated                         intervention indicated      Death

                             Gross hematuria; transfusion,
                             IV medications or
Symptomatic; urinary         hospitalization indicated;
catheter or bladder          elective endoscopic, radiologic   Life-threatening
irrigation indicated;        or operative intervention         consequences; urgent
limiting instrumental        indicated; limiting self care     radiologic or operative
ADL                          ADL                               intervention indicated      Death




-                            -                                 -                           -

Adults: 2+ proteinuria;
urinary protein 1.0 - 3.4    Adults: urinary protein >3.5
g/24 hrs; Pediatric: urine   g/24 hrs;
P/C (Protein/Creatinine)
ratio 0.5 - 1.9              Pediatric: urine P/C >1.9         -                           -
Symptomatic; oral
antiemetics indicated;
around the clock             Hospitalization indicated; IV     Life-threatening
nonprescription              intervention (e.g., analgesics,   consequences; urgent
analgesics or any oral       antiemetics); elective            radiologic, endoscopic or
narcotic analgesics          endoscopic or radiologic          operative intervention
indicated                    intervention indicated            indicated                   Death
Moderate pain; limiting
instrumental ADL;
prescription medication      Hospitalization indicated;
indicated                    limiting self care ADL            -                           -
                             Transfusion, radiation, or
                             hospitalization indicated;        Life-threatening
Analgesics and               elective radiologic, endoscopic   consequences; urgent
hematocrit monitoring        or operative intervention         radiologic or operative
indicated                    indicated                         intervention indicated      Death
Noninvasive               Limiting self care ADL; elective
intervention indicated;   radiologic, endoscopic or           Life-threatening
urinary or suprapubic     operative intervention              consequences; urgent
catheter placement        indicated; permanent urinary        radiologic or operative
indicated                 diversion indicated                 intervention indicated      Death

Limiting instrumental
ADL; medical
management indicated       -                                  -                           -
                          Intervention indicated (e.g.,
                          clamp, collagen injections);
Spontaneous; pads         operative intervention
indicated; limiting       indicated; limiting self care
instrumental ADL          ADL                                 -                           -
Placement of urinary,
suprapubic or              Elective operative or radiologic   Life-threatening
intermittent catheter      intervention indicated;            consequences; organ
placement indicated;       substantial loss of affected       failure; urgent operative
medication indicated       kidney function or mass            intervention indicated      Death
                           Symptomatic and altered
Symptomatic but no         organ function (e.g.,
hydronephrosis, sepsis hydronephrosis, or renal
or renal dysfunction;      dysfunction); elective
urethral dilation, urinary radiologic, endoscopic or          Life-threatening
or suprapubic catheter operative intervention                 consequences; urgent
indicated                  indicated                          intervention indicated      Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                   -                           -

Limiting instrumental
ADL; medical
management indicated       -                                  -                           -

-                          -                                  -                           -


                         Severe or medically significant
                         but not immediately life-
                         threatening; hospitalization or
Moderate, local or       prolongation of existing
noninvasive intervention hospitalization indicated;      Life-threatening
indicated; limiting      disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated           Death

-                         Absence of sperm in ejaculate       -                           -
Moderate asymmetry;         Asymmetry >1/3 of breast
moderate atrophy            volume; severe atrophy            -                        -

Moderate pain; limiting     Severe pain; limiting self care
instrumental ADL            ADL                               -                        -
Moderate symptoms;
limiting instrumental       Severe symptoms; limiting self
ADL                         care ADL                       -                           -


Moderate discomfort or
pain associated with
vaginal penetration;        Severe discomfort or pain
discomfort or pain          associated with vaginal
partially relieved with     penetration; discomfort or
use of vaginal lubricants   pain unrelieved by vaginal
or estrogen                 lubricants or estrogen            -                        -

Anejaculation or
retrograde ejaculation                                        -                        -


                        Decrease in erectile function
Decrease in erectile    (frequency/rigidity of
function                erections) but erectile
(frequency/rigidity of  intervention not helpful (e.g.,
erections), erectile    medication or mechanical
intervention indicated, devices such as penile pump);
(e.g., medication or    placement of a permanent
mechanical devices such penile prosthesis indicated
as penile pump)         (not previously present)              -                        -
                        Severe symptoms; elective
Mild symptoms; elective operative intervention
intervention indicated indicated                               -                       -
                                                              Life-threatening
                                                              consequences; urgent
Symptomatic and             Severe symptoms; elective         operative intervention
intervention not            operative intervention            indicated (e.g., organ
indicated                   indicated                         resection)               Death

Symptomatic and             Severe symptoms; elective         Life-threatening
intervention not            operative intervention            consequences; urgent
indicated                   indicated                         intervention indicated   Death
Moderate symptoms;
medical intervention
indicated                   -                                 -                        -
Readily apparent
obscuration of anatomic
architecture;
obliteration of skin
folds; readily apparent Lymphorrhea; gross deviation
deviation from normal from normal anatomic
anatomic contour        contour; limiting self care ADL -                          -
                        Severe symptoms; elective
Symptomatic (e.g., pain operative intervention
or psychosocial impact) indicated                       -                          -

                          Severe bleeding; transfusion   Life-threatening
Moderate bleeding;        indicated; radiologic or       consequences; urgent
medical intervention      endoscopic intervention        operative intervention
indicated                 indicated                      indicated                 Death
Intermittent menses
with skipped menses for
more than 4 to 6          Persistent amenorrhea for
months                    more than 6 months              -                        -
Changes in lactation,
significantly affecting
breast production or
expression of breast
milk                      -                               -                        -
Moderate symptoms;
medical intervention      Severe; transfusion indicated; Life-threatening
indicated (e.g.,          surgical intervention indicated consequences; urgent
hormones)                 (e.g., hysterectomy)            intervention indicated   Death

Symptomatic;
asymmetry of nipple
areolar complex with
moderate retraction
and/or thickening of the
nipple areolar complex -                                  -                        -
Sperm concentration 13 -
48 million/mL or         Sperm concentration <13
motility 32 - 68%        million/mL or motility <32%      -                        -

                          Severe bleeding; transfusion   Life-threatening
Moderate bleeding;        indicated; radiologic or       consequences; urgent
medical intervention      endoscopic intervention        operative intervention
indicated                 indicated                      indicated                 Death
                         Transfusion, radiologic,
Symptomatic and          endoscopic, or elective          Life-threatening
intervention not         operative intervention           consequences; urgent
indicated                indicated                        intervention indicated   Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -

Symptomatic, not
interfering with bladder,
bowel, or vaginal                                        Life-threatening
function; limiting        Severe symptoms; limiting self consequences; urgent
instrumental ADL          care ADL                       intervention indicated    Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -


-                        Present                           -                       -
                         Severe bleeding; transfusion     Life-threatening
Moderate bleeding;       indicated; radiologic or         consequences; urgent
medical intervention     endoscopic intervention          operative intervention
indicated                indicated                        indicated                Death

                        Severe symptoms; elective
Mild symptoms; elective operative intervention
intervention indicated indicated                          -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                        -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -                       -
                        Severe bleeding; transfusion      Life-threatening
Moderate bleeding;      indicated; radiologic or          consequences; urgent
medical intervention    endoscopic intervention           operative intervention
indicated               indicated                         indicated                Death
                        Severe symptoms; elective
Mild symptoms; elective operative intervention
intervention indicated indicated                          -                        -
Symptomatic but not
interfering with
urination or sexual         Severe symptoms; interfering
activities; intervention    with urination or sexual          Life-threatening
not indicated; limiting     function; limiting self care      consequences; urgent
instrumental ADL            ADL; intervention indicated       intervention indicated   Death
                            Severe bleeding; transfusion      Life-threatening
Moderate bleeding;          indicated; radiologic or          consequences; urgent
medical intervention        endoscopic intervention           operative intervention
indicated                   indicated                         indicated                Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                   -                        -

Symptomatic and         Severe symptoms; elective             Life-threatening
intervention not        operative intervention                consequences; urgent
indicated               indicated                             intervention indicated   Death
                        Severe bleeding; transfusion          Life-threatening
Moderate bleeding;      indicated; radiologic or              consequences; urgent
medical intervention    endoscopic intervention               operative intervention
indicated               indicated                             indicated                Death
                        Severe symptoms; elective
Mild symptoms; elective operative intervention
intervention indicated indicated                              -                        -

Moderate pain; limiting     Severe pain; limiting self care
instrumental ADL            ADL                               -                        -
Moderate to heavy
vaginal discharge; use of
perineal pad or tampon
indicated                   -                                 -                        -
Moderate vaginal
dryness interfering with
sexual function or          Severe vaginal dryness
causing frequent            resulting in dyspareunia or
discomfort                  severe discomfort                 -                        -

Symptomatic and             Severe symptoms; elective         Life-threatening
intervention not            operative intervention            consequences; urgent
indicated                   indicated                         intervention indicated   Death

                            Severe bleeding; transfusion      Life-threatening
Moderate bleeding;          indicated; radiologic or          consequences; urgent
medical intervention        endoscopic intervention           operative intervention
indicated                   indicated                         indicated                Death
                                                           Widespread areas of
Moderate discomfort or  Severe discomfort or pain,         mucosal ulceration; life-
pain, edema, or redness;edema, or redness; limiting        threatening consequences;
limiting instrumental   self care ADL; small areas of      urgent intervention
ADL                     mucosal ulceration                 indicated                 Death
                        Severe symptoms; elective
Mild symptoms; elective operative intervention
intervention indicated indicated                            -                          -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                 -                          -

Symptomatic and             Severe symptoms; elective      Life-threatening
intervention not            operative intervention         consequences; urgent
indicated                   indicated                      intervention indicated      Death

Vaginal narrowing           Vaginal narrowing and/or
and/or shortening not       shortening interfering with the
interfering with physical   use of tampons, sexual activity
examination                 or physical examination         -                          Death
Moderate discomfort or
pain associated with
vaginal                     Severe discomfort or pain
spasm/tightening;           associated with vaginal
disruption in sexual        spasm/tightening; unable to
function and physical       tolerate vaginal penetration or
examination                 physical examination            -                          -


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;         Life-threatening
limiting age-appropriate disabling; limiting self care     consequences; urgent
instrumental ADL         ADL                               Life-threatening respiratory Death
                                                           intervention indicated
                                                           or hemodynamic
                            Present with radiologic        compromise; intubation or
                            findings; intubation not       urgent intervention
-                           indicated                      indicated                 Death


Moderate symptoms;
medical intervention
indicated                   -                               -                          -
                                                          Life-threatening respiratory
                                                          or hemodynamic
                                                          compromise; intubation or
                            Present; medical intervention urgent intervention
-                           indicated                     indicated                    Death

Altered eating habits;
coughing or choking         Dyspnea and pneumonia            Life-threatening respiratory
episodes after eating or    symptoms (e.g., aspiration       or hemodynamic
swallowing; medical         pneumonia); hospitalization      compromise; intubation or
intervention indicated      indicated; unable to aliment     urgent intervention
(e.g., suction or oxygen)   orally                           indicated                    Death
Symptomatic (e.g.,
dyspnea, cough);
medical intervention
indicated (e.g., chest                                       Life-threatening respiratory
physiotherapy,              Oxygen indicated;                or hemodynamic
suctioning);                hospitalization or elective      compromise; intubation or
bronchoscopic               operative intervention           urgent intervention
suctioning                  indicated (e.g., stent, laser)   indicated                    Death


                                                           Life-threatening
Symptomatic; tube           Severe symptoms; limiting self consequences; urgent
thoracostomy or             care ADL; endoscopic or        operative intervention with
medical management          operative intervention         thoracoplasty, chronic
indicated; limiting         indicated (e.g., stent or      open drainage or multiple
instrumental ADL            primary closure)               thoracotomies indicated     Death




Symptomatic (e.g., mild
wheezing); endoscopic
evaluation indicated;
radiographic evidence of
atelectasis/lobar                                            Life-threatening respiratory
collapse; medical           Shortness of breath with         or hemodynamic
management indicated        stridor; endoscopic              compromise; intubation or
(e.g., steroids,            intervention indicated (e.g.,    urgent intervention
bronchodilators)            laser, stent placement)          indicated                    Death
Symptomatic (e.g.,
rhonchi or wheezing)
but without respiratory                                    Life-threatening respiratory
distress; medical          Shortness of breath with        or hemodynamic
intervention indicated     stridor; endoscopic             compromise; intubation or
(e.g., steroids,           intervention indicated (e.g.,   urgent intervention
bronchodilators)           laser, stent placement)         indicated                    Death


                                                          Life-threatening
Symptomatic; tube          Severe symptoms; limiting self consequences; urgent
thoracostomy or            care ADL; endoscopic or        operative intervention with
medical intervention       operative intervention         thoracoplasty, chronic
indicated; limiting        indicated (e.g., stent or      open drainage or multiple
instrumental ADL           primary closure)               thoracotomies indicated     Death

                                                           Life-threatening respiratory
                           Transfusion, radiologic,        or hemodynamic
Moderate symptoms;         endoscopic, or operative        compromise; intubation or
medical intervention       intervention indicated (e.g.,   urgent intervention
indicated                  hemostasis of bleeding site)    indicated                    Death

                                                          Life-threatening respiratory
Symptomatic; medical                                      or hemodynamic
intervention indicated;                                   compromise; intubation or
limiting instrumental      Limiting self care ADL; oxygen urgent intervention
ADL                        saturation decreased           indicated                    Death

                                                           Life-threatening respiratory
                                                           or hemodynamic
Symptomatic;               Severe symptoms; elective       compromise; intubation or
thoracentesis or tube      operative intervention          urgent intervention
drainage indicated         indicated                       indicated                    Death
Moderate symptoms,
medical intervention
indicated; limiting        Severe symptoms; limiting self
instrumental ADL           care ADL                       -                            -
Shortness of breath with
minimal exertion;                                          Life-threatening
limiting instrumental      Shortness of breath at rest;    consequences; urgent
ADL                        limiting self care ADL          intervention indicated      Death
Moderate symptoms;
medical intervention        Transfusion, radiologic,
indicated (e.g., nasal      endoscopic, or operative         Life-threatening
packing, cauterization;     intervention indicated (e.g.,    consequences; urgent
topical vasoconstrictors)   hemostasis of bleeding site)     intervention indicated    Death
Moderate symptoms;
medical intervention        Severe symptoms; interfering
indicated; limiting         with sleep; limiting self care
instrumental ADL            ADL                              -                         -

Moderate or persistent
voice changes; may
require occasional
repetition but
understandable on      Severe voice changes including
telephone; medical     predominantly whispered
evaluation indicated   speech                         -                                -

Decreased oxygen
saturation with exercise                                     Life-threatening airway
(e.g., pulse oximeter    Decreased oxygen saturation         compromise; urgent
<88%); intermittent      at rest (e.g., pulse oximeter       intervention indicated (e.g.,
supplemental oxygen      <88% or PaO2 <=55 mm Hg)            tracheotomy or intubation) Death

Symptomatic; medical
intervention indicated                                       Life-threatening airway
(e.g., dexamethasone,                                        compromise; urgent
epinephrine,                Stridor; respiratory distress;   intervention indicated (e.g.,
antihistamines)             hospitalization indicated        tracheotomy or intubation) Death

                                                           Life-threatening
                                                           consequences; urgent
Symptomatic; tube           Severe symptoms; limiting self operative intervention
thoracostomy or             care ADL; endoscopic or        indicated (e.g.,
medical management          operative intervention         thoracoplasty, chronic
indicated; limiting         indicated (e.g., stent or      open drainage or multiple
instrumental ADL            primary closure)               thoracotomies)              Death

                            Transfusion, radiologic,         Life-threatening airway
Moderate symptoms;          endoscopic, or operative         compromise; urgent
medical intervention        intervention indicated (e.g.,    intervention indicated (e.g.,
indicated                   hemostasis of bleeding site)     tracheotomy or intubation) Death

Moderate sore throat;       Severe throat pain; endoscopic
analgesics indicated        intervention indicated         -                           -
                                                          Life-threatening airway
                         Severe pain; severely altered    compromise; urgent
Moderate discomfort;     eating/swallowing; medical       intervention indicated (e.g.,
altered oral intake      intervention indicated           tracheotomy or intubation) Death


Symptomatic (e.g., noisy
airway breathing), but
causing no respiratory
distress; medical
management indicated Limiting self care ADL; stridor; Life-threatening
(e.g., steroids); limiting endoscopic intervention        consequences; urgent
instrumental ADL           indicated (e.g., stent, laser) intervention indicated      Death


Symptomatic (e.g., noisy
airway breathing), but
causing no respiratory
distress; medical        Limiting self care ADL; stridor; Life-threatening
management indicated endoscopic intervention              consequences; urgent
(e.g., steroids)         indicated (e.g., stent, laser)   intervention indicated      Death

Moderate symptoms;
mild anxiety, but no
dyspnea; short duration
of observation and or
anxiolytic indicated;   Severe symptoms; dyspnea
limiting instrumental   and swallowing difficulty;        Life-threatening
ADL                     limiting self care ADL            consequences                Death


                                                          Persistent or severe
                         Recurrent episodes;              episodes associated with
                         noninvasive intervention         syncope; urgent
Transient episode;       indicated (e.g., breathing       intervention indicated (e.g.,
intervention not         technique, pressure point        fiberoptic laryngoscopy,
indicated                massage)                         intubation, botox injection) Death
                         Transfusion, radiologic,
                         endoscopic, or elective
Moderate symptoms;       operative intervention           Life-threatening
medical intervention     indicated (e.g., hemostasis of   consequences; urgent
indicated                bleeding site)                   intervention indicated      Death
Moderate symptoms;
medical intervention     Associated with bloody nasal
indicated                discharge or epistaxis           -                           -
Symptomatic; tube             Severe symptoms; limiting self
thoracostomy or               care ADL; endoscopic or
medical intervention          operative intervention         Life-threatening
indicated; limiting           indicated (e.g., stent or      consequences; urgent
instrumental ADL              primary closure)               intervention indicated         Death

                                                                Life-threatening respiratory
                              Transfusion, radiologic,          or hemodynamic
Moderate symptoms;            endoscopic, or operative          compromise; intubation or
medical intervention          intervention indicated (e.g.,     urgent intervention
indicated                     hemostasis of bleeding site)      indicated                    Death
Moderate pain and
analgesics indicated;
altered oral intake;          Severe pain; unable to         Life-threatening
limiting instrumental         adequately aliment or hydrate consequences; urgent
ADL                           orally; limiting self care ADL intervention indicated         Death

                              Inability to aliment adequately
                              by GI tract; tube feeding or      Life-threatening
                              TPN indicated; radiologic,        consequences; urgent
                              endoscopic, or operative          operative intervention
-                             intervention indicated            indicated                   Death


Symptomatic (e.g., noisy
airway breathing), but
causing no respiratory
distress; medical                                               Life-threatening airway
management indicated Limiting self care ADL; stridor;           compromise; urgent
(e.g., steroids); limiting endoscopic intervention              intervention indicated (e.g.,
instrumental ADL           indicated (e.g., stent, laser)       tracheotomy or intubation) Death

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL

Symptomatic;                                                 Life-threatening respiratory
intervention indicated        Symptomatic with respiratory or hemodynamic
(e.g., diuretics or limited   distress and hypoxia; surgical compromise; intubation or
therapeutic                   intervention including chest   urgent intervention
thoracentesis)                tube or pleurodesis indicated indicated                     Death

                        >1000 ml of blood evacuated;
                        persistent bleeding (150-200            Life-threatening respiratory
Symptomatic or          ml/hr for 2 - 4 hr); persistent         or hemodynamic
associated with         transfusion indicated; elective         compromise; intubation or
pneumothorax; chest     operative intervention                  urgent intervention
tube drainage indicated indicated                               indicated                    Death
Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                               -                            -


Symptomatic; medical                                     Life-threatening respiratory
intervention indicated;                                  compromise; urgent
limiting instrumental     Severe symptoms; limiting self intervention indicated (e.g.,
ADL                       care ADL; oxygen indicated     tracheotomy or intubation) Death

Symptomatic;
intervention indicated    Sclerosis and/or operative      Life-threatening
(e.g., tube placement     intervention indicated;         consequences; urgent
without sclerosis)        hospitalization indicated       intervention indicated      Death
Moderate symptoms;
medical intervention
indicated                  -                             -                             -
Moderate sputum           Persistent or copious
production; limiting      production of sputum; limiting
instrumental ADL          self care ADL                  -                             -


Moderate dyspnea on                                        Life-threatening respiratory
exertion; medical                                          compromise; urgent
intervention indicated;   Severe dyspnea or dyspnea at intervention or intubation
limiting instrumental     rest; oxygen indicated; limiting with ventilatory support
ADL                       self care ADL                    indicated                    Death


                                                          Life-threatening
                                                          consequences (e.g.,
                                                          hemodynamic/pulmonary
Moderate hypoxemia;                                       complications); intubation
evidence of pulmonary     Severe hypoxemia; evidence      with ventilatory support
hypertension;             of right-sided heart failure;   indicated; radiographic
radiographic pulmonary    radiographic pulmonary          pulmonary fibrosis >75%
fibrosis 25 - 50%         fibrosis >50 - 75%              with severe honeycombing Death
Symptomatic; tube
thoracostomy or           Limiting self care ADL;         Life-threatening
medical management        endoscopic stenting or          consequences; urgent
indicated; limiting       operative intervention          operative intervention
instrumental ADL          indicated                       indicated                   Death
Moderate dyspnea,
cough; requiring                                          Life-threatening airway
evaluation by cardiac     Severe symptoms, associated     consequences; urgent
catheterization and       with hypoxemia, right heart     intervention indicated (e.g.,
medical intervention      failure; oxygen indicated       tracheotomy or intubation) Death
                                                            Life-threatening
                                                            consequences; urgent
                                                            intervention, intubation, or
                                                            ventilatory support
-                           -                               indicated                    Death

Moderate signs or                                           Life-threatening
symptoms; steroids          Severe symptoms;                consequences; ventilatory
indicated                   hospitalization indicated       support indicated         Death

Symptomatic stenosis or
edema/narrowing
interfering with airflow;   Stenosis with significant nasal Necrosis of soft tissue or
limiting instrumental       obstruction; limiting self care bone; urgent operative
ADL                         ADL                             intervention indicated       Death
Moderate apnea and
oxygen desaturation;
excessive daytime           Oxygen desaturation;            Cardiovascular or
sleepiness; medical         associated with hypertension;   neuropsychiatric
evaluation indicated;       medical intervention            symptoms; urgent
limiting instrumental       indicated; limiting self care   operative intervention
ADL                         ADL                             indicated                    Death
Moderate symptoms;
medical intervention
indicated                   -                                -                           -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL; limiting ability to swallow -                               -

                                                            Life-threatening airway
                            Respiratory distress limiting   compromise; urgent
                            self care ADL; medical          intervention indicated (e.g.,
-                           intervention indicated          tracheotomy or intubation) Death

                                                           Life-threatening
                                                           consequences; urgent
Symptomatic; tube           Severe symptoms; limiting self operative intervention
thoracostomy or             care ADL; endoscopic or        indicated (e.g.,
medical intervention        operative intervention         thoracoplasty, chronic
indicated; limiting         indicated (e.g., stent or      open drainage or multiple
instrumental ADL            primary closure)               thoracotomies)                Death
Moderate symptoms;
medical intervention        Severe pain; hemorrhage or     Life-threatening
indicated; limiting         respiratory symptoms; limiting consequences; urgent
instrumental ADL            self care ADL                  intervention indicated        Death
Symptomatic (e.g., noisy
airway breathing), but
causing no respiratory     Stridor or respiratory distress   Life-threatening airway
distress; medical          limiting self care ADL;           compromise; urgent
management indicated       endoscopic intervention           intervention indicated (e.g.,
(e.g., steroids)           indicated (e.g., stent, laser)    tracheotomy or intubation) Death


                       Severe voice changes including
                       predominantly whispered
                       speech; may require frequent
Moderate or persistent repetition or face-to-face
change from normal     contact for understandability;
voice; still           may require assistive
understandable         technology                     -                                -

Moderate symptoms;         Severe respiratory symptoms
medical intervention       limiting self care ADL; oxygen    Life-threatening
indicated; limiting        therapy or hospitalization        consequences; urgent
instrumental ADL           indicated                         intervention indicated    Death




                           Severe or medically significant
Moderate; minimal,         but not immediately life-
local or noninvasive       threatening; hospitalization or
intervention indicated;    prolongation of existing          Life-threatening
limiting age-appropriate   hospitalization indicated;        consequences; urgent
instrumental ADL           disabling; limiting self care ADL intervention indicated    Death

Hair loss of >50%
normal for that
individual that is readily
apparent to others; a
wig or hair piece is
necessary if the patient
desires to completely
camouflage the hair
loss; associated with
psychosocial impact        -                                 -                         -
Pronounced odor;
psychosocial impact;
patient seeks medical
intervention               -                                 -                         -
                                                               Blisters covering >30% BSA;
Blisters covering 10 -                                         associated with fluid or
30% BSA; painful                                               electrolyte abnormalities;
blisters; limiting           Blisters covering >30% BSA;       ICU care or burn unit
instrumental ADL             limiting self care ADL            indicated                   Death
Covering 10 - 30% BSA
and associated with
erythema or pruritus;        Covering >30% BSA and
limiting instrumental        associated with pruritus;
ADL                          limiting self care ADL             -                         -
                                                               Target lesions covering
Target lesions covering                                        >30% BSA; associated with
10 - 30% BSA and             Target lesions covering >30%      fluid or electrolyte
associated with skin         BSA and associated with oral      abnormalities; ICU care or
tenderness                   or genital erosions               burn unit indicated        Death

                                                               Erythema covering >90%
Erythema covering >90%       Erythema covering >90% BSA        BSA with associated fluid or
BSA without associated       with associated symptoms          electrolyte abnormalities;
symptoms; limiting           (e.g., pruritus or tenderness);   ICU care or burn unit
instrumental ADL             limiting self care ADL            indicated                    Death
Covering 10 - 30% BSA
and associated with
erythema or tenderness;      Covering >30% BSA; associated
limiting instrumental        with erythema or tenderness;
ADL                          limiting self-care ADL        -                               -

In women, increase in
length, thickness or
density of hair in a male
distribution that
requires daily shaving or
consistent destructive
means of hair removal
to camouflage;
associated with
psychosocial impact           -                                -                           -
Involving >1 site; patient   Generalized involving sites
seeks medical                other than palms, soles, or
intervention; associated     axillae; associated with
with psychosocial            electrolyte/hemodynamic
impact                       imbalance                         -                           -
Increase in length,
thickness or density of
hair at least on the usual
exposed areas of the
body [face (not limited
to beard/moustache
area) plus/minus arms]
that requires frequent
shaving or use of
destructive means of
hair removal to
camouflage; associated
with psychosocial
impact                     -                               -          -

Symptomatic; limiting     Increase in body temperature;
instrumental ADL          limiting self care ADL        Heat stroke   Death

                          Covering >30% BSA and
Covering 10 - 30% BSA     associated tenderness and
and associated            narcotics or NSAIDs indicated;
tenderness; limiting      lipohypertrophy; limiting self
instrumental ADL          care ADL                         -          -




                           -                               -          -

Symptomatic separation
of the nail bed from the
nail plate or nail loss;
limiting instrumental
ADL                      -                                 -          -




-                          -                               -          -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -          -
Skin changes (e.g.,
peeling, blisters,          Severe skin changes (e.g.,
bleeding, edema, or         peeling, blisters, bleeding,
hyperkeratosis) with        edema, or hyperkeratosis)
pain; limiting              with pain; limiting self care
instrumental ADL            ADL                              -                       -

                            Edema associated with visual
                            disturbance; increased
                            intraocular pressure, glaucoma
                            or retinal hemorrhage; optic
Indurated or pitting        neuritis; diuretics indicated;
edema; topical              operative intervention
intervention indicated      indicated                      -                         -

                            Erythema covering >30% BSA
                            and erythema with blistering;
                            photosensitivity; oral
                            corticosteroid therapy
                            indicated; pain control         Life-threatening
Tender erythema             indicated (e.g., narcotics or   consequences; urgent
covering 10 - 30% BSA       NSAIDs)                         intervention indicated   Death


Intense or widespread;
intermittent; skin
changes from scratching
(e.g., edema,
papulation, excoriations,
lichenification,            Intense or widespread;
oozing/crusts); oral        constant; limiting self care ADL
intervention indicated;     or sleep; oral corticosteroid or
limiting instrumental       immunosuppressive therapy
ADL                         indicated                        -                       -
Combined area of
lesions covering 10 -       Combined area of lesions
30% BSA; bleeding with      covering >30% BSA;
trauma                      spontaneous bleeding             -                       -
                                                      Papules and/or pustules
Papules and/or pustules                               covering any % BSA, which
covering 10 - 30% BSA, Papules and/or pustules        may or may not be
which may or may not covering >30% BSA, which may associated with symptoms
be associated with      or may not be associated with of pruritus or tenderness
symptoms of pruritus or symptoms of pruritus or       and are associated with
tenderness; associated tenderness; limiting self care extensive superinfection
with psychosocial       ADL; associated with local    with IV antibiotics
impact; limiting        superinfection with oral      indicated; life-threatening
instrumental ADL        antibiotics indicated         consequences                Death
Macules/papules
covering 10 - 30% BSA
with or without
symptoms (e.g.,         Macules/papules covering
pruritus, burning,      >30% BSA with or without
tightness); limiting    associated symptoms; limiting
instrumental ADL        self care ADL                  -                          -

Moderate pain; limiting Severe pain; limiting self care
instrumental ADL        ADL                                -                         -

Covering 10 - 30% BSA;
associated with striae or   Covering >30% BSA; associated
adnexal structure loss      with ulceration               -                          -
Hyperpigmentation
covering >10% BSA;
associated psychosocial
impact                      -                              -                         -
Hypopigmentation or
depigmentation
covering >10% BSA;
associated psychosocial
impact                      -                              -                         -
                           Severe induration, unable to
Moderate induration,       slide or pinch skin; limiting   Generalized; associated
able to slide skin, unable joint movement or orifice       with signs or symptoms of
to pinch skin; limiting    (e.g., mouth, anus); limiting   impaired breathing or
instrumental ADL           self care ADL                   feeding                   Death
                                                         Any size ulcer with
                        Combined area of ulcers >2       extensive destruction,
Combined area of ulcers cm; full-thickness skin loss     tissue necrosis, or damage
1 - 2 cm; partial       involving damage to or           to muscle, bone, or
thickness skin loss     necrosis of subcutaneous         supporting structures with
involving skin or       tissue that may extend down      or without full thickness
subcutaneous fat        to fascia                        skin loss                  Death

                                                          Skin sloughing covering 10 -
                         Skin sloughing covering <10% 30% BSA with associated
                         BSA with associated signs (e.g., signs (e.g., erythema,
                         erythema, purpura, epidermal purpura, epidermal
                         detachment and mucous            detachment and mucous
                         membrane detachment)             membrane detachment)         Death
Telangiectasias covering
>10% BSA; associated
with psychosocial
impact                   -                               -                            -

                                                         Skin sloughing covering
                                                         >=30% BSA with associated
                                                         symptoms (e.g., erythema,
                                                         purpura, or epidermal
-                        -                               detachment)               Death

Urticarial lesions
covering 10 - 30% BSA;   Urticarial lesions covering
oral intervention        >30% BSA; IV intervention
indicated                indicated                       -                            -


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated      Death

Menopause occurring at Menopause occurring before
age 40 - 45 years of age age 40 years of age             -                            -
                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated   Death


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated   Death



                                                         Life-threatening
Symptomatic; medical     Severe symptoms;                consequences; urgent
intervention indicated   intervention indicated          intervention indicated   Death
Moderate symptoms;       Symptomatic, associated with
medical intervention     hypotension and/or
indicated; limiting      tachycardia; limiting self care
instrumental ADL         ADL                              -                       -
                         Transfusion, radiologic,
Minimally invasive       endoscopic, or elective         Life-threatening
evacuation or aspiration operative intervention          consequences; urgent
indicated                indicated                       intervention indicated   Death
Moderate symptoms;
limiting instrumental    Severe symptoms; limiting self
ADL                      care ADL                         -                       -
Stage 1 hypertension
(systolic BP 140 - 159
mm Hg or diastolic BP
90 - 99 mm Hg); medical
intervention indicated;
recurrent or persistent
(>=24 hrs); symptomatic
increase by >20 mm Hg
(diastolic) or to >140/90Stage 2 hypertension (systolic    Life-threatening
mm Hg if previously      BP >=160 mm Hg or diastolic       consequences (e.g.,
WNL; monotherapy         BP >=100 mm Hg); medical          malignant hypertension,
indicated                intervention indicated; more      transient or permanent
                         than one drug or more             neurologic deficit,
Pediatric: recurrent or intensive therapy than             hypertensive crisis); urgent
persistent (>=24 hrs) BP previously used indicated         intervention indicated
>ULN; monotherapy
indicated                Pediatric: Same as adult          Pediatric: Same as adult       Death

Non-urgent medical          Medical intervention or        Life-threatening and urgent
intervention indicated      hospitalization indicated      intervention indicated      Death
                            Severe symptoms; radiologic,
                            endoscopic or elective         Life-threatening
Symptomatic; medical        operative intervention         consequences; urgent
intervention indicated      indicated                      intervention indicated         Death

Marked discoloration;
leathery skin texture;
papillary formation;
limiting instrumental       Severe symptoms; limiting self
ADL                         care ADL                       -                              -
                            Severe symptoms; radiologic,
                            endoscopic or elective
Symptomatic; medical        operative intervention
intervention indicated      indicated                      -                              -

Brief (<24 hrs) episode                                    Life-threatening
of ischemia managed                                        consequences; evidence of
non-surgically and          Recurring or prolonged (>=24   end organ damage; urgent
without permanent           hrs) and/or invasive           operative intervention
deficit                     intervention indicated         indicated                 Death
Present                      -                              -                        -

Present                     -                              -                              -
                          Severe symptoms; multi-
Symptomatic; medical      modality intervention           Life-threatening
intervention indicated    indicated (e.g.,                consequences; urgent
(e.g., anticoagulation,   anticoagulation,                multi-modality intervention
radiation or              chemotherapy, radiation,        indicated (e.g., lysis,
chemotherapy)             stenting)                       thrombectomy, surgery)      Death
                                                          Life-threatening (e.g.,
                                                          pulmonary embolism,
                          Thrombosis (e.g.,               cerebrovascular event,
Venous thrombosis         uncomplicated pulmonary         arterial insufficiency);
(e.g., uncomplicated      embolism [venous], non-         hemodynamic or
deep vein thrombosis),    embolic cardiac mural           neurologic instability;
medical intervention      [arterial] thrombus), medical   urgent intervention
indicated                 intervention indicated          indicated                   Death

                                                          Life-threatening; evidence
Moderate symptoms,        Severe symptoms, medical        of peripheral or visceral
medical intervention      intervention indicated (e.g.,   ischemia; urgent
indicated                 steroids)                       intervention indicated     Death

                                                          Life-threatening
Brief (<24 hrs) episode                                   consequences; evidence of
of ischemia managed       Prolonged (>=24 hrs) or         end organ damage; urgent
medically and without     recurring symptoms and/or       operative intervention
permanent deficit         invasive intervention indicated indicated                 Death


                         Severe or medically significant
                         but not immediately life-
Moderate; minimal,       threatening; hospitalization or
local or noninvasive     prolongation of existing
intervention indicated; hospitalization indicated;       Life-threatening
limiting age-appropriate disabling; limiting self care   consequences; urgent
instrumental ADL         ADL                             intervention indicated      Death
                        CTCAE v4.0 AE Term Definition

A disorder characterized by an reduction in the amount of hemoglobin in 100 ml of
blood. Signs and symptoms of anemia may include pallor of the skin and mucous
membranes, shortness of breath, palpitations of the heart, soft systolic murmurs,
lethargy, and fatigability.




A disorder characterized by the inability of the bone marrow to produce
hematopoietic elements.
A disorder characterized by systemic pathological activation of blood clotting
mechanisms which results in clot formation throughout the body. There is an
increase in the risk of hemorrhage as the body is depleted of platelets and
coagulation factors.



A disorder characterized by a decrease in neutrophils associated with fever.




A disorder characterized by laboratory test results that indicate widespread
erythrocyte cell membrane destruction.




A disorder characterized by a form of thrombotic microangiopathy with renal
failure, hemolytic anemia, and severe thrombocytopenia.


A disorder characterized by laboratory test results that indicate an increased
number of white blood cells in the blood.



A disorder characterized by a sensation of marked discomfort in a lymph node.




A disorder of the spleen.


A disorder characterized by the presence of microangiopathic hemolytic anemia,
thrombocytopenic purpura, fever, renal abnormalities and neurological
abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute
or subacute condition.
A disorder characterized by signs and symptoms related to acute ischemia of the
myocardium secondary to coronary artery disease. The clinical presentation
covers a spectrum of heart diseases from unstable angina to myocardial
infarction.




A disorder characterized by a defect in aortic valve function or structure.


A disorder characterized by a dysrhythmia without cardiac electrical activity.
Typically, this is accompanied by cessation of the pumping function of the heart.



A disorder characterized by a dysrhythmia without discernible P waves and an
irregular ventricular response due to multiple reentry circuits. The rhythm
disturbance originates above the ventricles.



A disorder characterized by a dysrhythmia with organized rhythmic atrial
contractions with a rate of 200-300 beats per minute. The rhythm disturbance
originates in the atria.




A disorder characterized by a dysrhythmia with complete failure of atrial electrical
impulse conduction through the AV node to the ventricles.

A disorder characterized by a dysrhythmia with a delay in the time required for the
conduction of an electrical impulse through the atrioventricular (AV) node beyond
0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.



A disorder characterized by cessation of the pumping function of the heart.
A disorder characterized by substernal discomfort due to insufficient myocardial
oxygenation.


A disorder characterized by pathological irregularities in the cardiac conduction
system.


A disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic
changes impede normal myocardial function by restricting myocardial muscle
action.




A disorder characterized by the inability of the heart to pump blood at an adequate
volume to meet tissue metabolic requirements, or, the ability to do so only at an
elevation in the filling pressure.




A disorder characterized by failure of the left ventricle to produce adequate output
despite an increase in distending pressure and in end-diastolic volume. Clinical
manifestations may include dyspnea, orthopnea, and other signs and symptoms
of pulmonary congestion and edema.




A disorder characterized by a defect in mitral valve function or structure.


A disorder characterized by a dysrhythmia with relatively constant PR interval prior
to the block of an atrial impulse. This is the result of intermittent failure of atrial
electrical impulse conduction through the atrioventricular (AV) node to the
ventricles.


A disorder characterized by a dysrhythmia with a progressively lengthening PR
interval prior to the blocking of an atrial impulse. This is the result of intermittent
failure of atrial electrical impulse conduction through the atrioventricular (AV) node
to the ventricles.




A disorder characterized by gross necrosis of the myocardium; this is due to an
interruption of blood supply to the area.
A disorder characterized by inflammation of the muscle tissue of the heart.


A disorder characterized by an unpleasant sensation of irregular and/or forceful
beating of the heart.



A disorder characterized by a dysrhythmia with abrupt onset and sudden
termination of atrial contractions with a rate of 150-250 beats per minute. The
rhythm disturbance originates in the atria.


A disorder characterized by fluid collection within the pericardial sac, usually due
to inflammation.


A disorder characterized by an increase in intrapericardial pressure due to the
collection of blood or fluid in the pericardium.



A disorder characterized by irritation to the layers of the pericardium (the
protective sac around the heart).




A disorder characterized by a defect in pulmonary valve function or structure.



A disorder characterized by an inability of the ventricles to fill with blood because
the myocardium (heart muscle) stiffens and loses its flexibility.




A disorder characterized by impairment of right ventricular function associated
with low ejection fraction and a decrease in motility of the right ventricular wall.


A disorder characterized by a dysrhythmia with alternating periods of bradycardia
and atrial tachycardia accompanied by syncope, fatigue and dizziness.


A disorder characterized by a dysrhythmia with a heart rate less than 60 beats per
minute that originates in the sinus node.
A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats
per minute that originates in the sinus node.


A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats
per minute that originates above the ventricles.




A disorder characterized by a defect in tricuspid valve function or structure.




A disorder characterized by a dysrhythmia that originates in the ventricles.



A disorder characterized by a dysrhythmia without discernible QRS complexes
due to rapid repetitive excitation of myocardial fibers without coordinated
contraction of the ventricles.




A disorder characterized by a dysrhythmia with a heart rate greater than 100 beats
per minute that originates distal to the bundle of His.



A disorder characterized by the presence of an accessory conductive pathway
between the atria and the ventricles that causes premature ventricular activation.
A disorder characterized by a sensation of marked discomfort in the ear.




A disorder characterized by inflammation, swelling and redness to the outer ear
and ear canal.


A disorder characterized by a sensation of marked discomfort in the external ear
region.
A disorder characterized by partial or complete loss of the ability to detect or
understand sounds resulting from damage to ear structures.


A disorder characterized by inflammation (physiologic response to irritation),
swelling and redness to the middle ear.


A disorder characterized by noise in the ears, such as ringing, buzzing, roaring or
clicking.
A disorder characterized by a sensation as if the external world were revolving
around the patient (objective vertigo) or as if he himself were revolving in space
(subjective vertigo).



A disorder characterized by dizziness, imbalance, nausea, and vision problems.
A disorder that occurs when the adrenal cortex does not produce enough of the
hormone cortisol and in some cases, the hormone aldosterone. It may be due to a
disorder of the adrenal cortex as in Addison's disease or primary adrenal
insufficiency.


A disorder characterized by signs and symptoms that resemble Cushing's disease
or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes,
and osteoporosis, usually due to exogenous corticosteroids.




A disorder characterized by unusually late sexual maturity.




A disorder characterized by greater growth than expected for age.
A disorder characterized by an increase in production of parathyroid hormone by
the parathyroid glands. This results in hypercalcemia (abnormally high levels of
calcium in the blood).


A disorder characterized by excessive levels of thyroid hormone in the body.
Common causes include an overactive thyroid gland or thyroid hormone
overdose.



A disorder characterized by a decrease in production of parathyroid hormone by
the parathyroid glands.



A disorder characterized by a decrease in production of thyroid hormone by the
thyroid gland.



A disorder characterized by unusually early development of secondary sexual
features; the onset of sexual maturation begins usually before age 8 for girls and
before age 9 for boys.


A disorder characterized by inappropriate masculinization occurring in a female or
prepubertal male.
A disorder characterized by visual perception of unclear or fuzzy images.




A disorder characterized by partial or complete opacity of the crystalline lens of
one or both eyes. This results in a decrease in visual acuity and eventual
blindness if untreated.




A disorder characterized by inflammation, swelling and redness to the conjunctiva
of the eye.




A disorder characterized by an area of epithelial tissue loss on the surface of the
cornea. It is associated with inflammatory cells in the cornea and anterior
chamber.




A disorder characterized by dryness of the cornea and conjunctiva.



A disorder characterized by incomplete paralysis of an extraocular muscle.



A disorder characterized by a sensation of marked discomfort in the eye.




A disorder characterized by impaired eyelid function.

A disorder characterized by a sudden or brief burst of light.
A disorder characterized by an individual seeing spots before their eyes. The
spots are shadows of opaque cell fragments in the vitreous humor or lens.




A disorder characterized by an increase in pressure in the eyeball due to
obstruction of the aqueous humor outflow.




A disorder characterized by inflammation to the cornea of the eye.



A disorder characterized by an inability to see clearly in dim light.




A disorder characterized by involvement of the optic nerve (second cranial nerve).




A disorder characterized by swelling around the optic disc.

A disorder characterized by fear and avoidance of light.




A disorder characterized by the separation of the inner retina layers from the
underlying pigment epithelium.


A disorder characterized by a small laceration of the retina, this occurs when the
vitreous separates from the retina. Symptoms include flashes and floaters.


A disorder characterized by pathological retinal blood vessels that adversely
affects vision.
A disorder involving the retina.




A disorder characterized by involvement of the sclera of the eye.



A disorder characterized by inflammation to the uvea of the eye.




A disorder characterized by blood extravasation into the vitreous humor.
A disorder of excessive tearing in the eyes; it can be caused by overproduction of
tears or impaired drainage of the tear duct.




A disorder characterized by swelling of the abdomen.


A disorder characterized by a sensation of marked discomfort in the abdominal
region.




A disorder characterized by an abnormal communication between the opening in
the anal canal to the perianal skin.




A disorder characterized by bleeding from the anal region.
A disorder characterized by inflammation of the mucous membrane of the anus.




A disorder characterized by a necrotic process occurring in the anal region.



A disorder characterized by a sensation of marked discomfort in the anal region.




A disorder characterized by a narrowing of the lumen of the anal canal.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the anal canal.



A disorder characterized by accumulation of serous or hemorrhagic fluid in the
peritoneal cavity.



A disorder characterized by subject-reported feeling of uncomfortable fullness of
the abdomen.




A disorder characterized by bleeding from the cecum.




A disorder characterized by inflammation of the lip.




A disorder characterized by inflammation of the colon.
A disorder characterized by an abnormal communication between the large
intestine and another organ or anatomic site.




A disorder characterized by bleeding from the colon.



A disorder characterized by blockage of the normal flow of the intestinal contents
in the colon.



A disorder characterized by a rupture in the colonic wall.




A disorder characterized by a narrowing of the lumen of the colon.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the colon.




A disorder characterized by irregular and infrequent or difficult evacuation of the
bowels.



A disorder characterized by the decay of a tooth, in which it becomes softened,
discolored and/or porous.




A disorder characterized by frequent and watery bowel movements.
A disorder characterized by reduced salivary flow in the oral cavity.




A disorder characterized by an abnormal communication between the duodenum
and another organ or anatomic site.




A disorder characterized by bleeding from the duodenum.



A disorder characterized by blockage of the normal flow of stomach contents
through the duodenum.




A disorder characterized by a rupture in the duodenal wall.




A disorder characterized by a narrowing of the lumen of the duodenum.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the duodenal wall.
A disorder characterized by an uncomfortable, often painful feeling in the
stomach, resulting from impaired digestion. Symptoms include burning stomach,
bloating, heartburn, nausea and vomiting.




A disorder characterized by difficulty in swallowing.
A disorder characterized by inflammation of the small and large intestines.



A disorder characterized by an abnormal communication between the urinary
bladder and the intestine.




A disorder characterized by an abnormal communication between the esophagus
and another organ or anatomic site.




A disorder characterized by bleeding from the esophagus.




A disorder characterized by a necrotic process occurring in the esophageal wall.




A disorder characterized by blockage of the normal flow of the contents in the
esophagus.


A disorder characterized by a sensation of marked discomfort in the esophageal
region.




A disorder characterized by a rupture in the wall of the esophagus.




A disorder characterized by a narrowing of the lumen of the esophagus.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the esophageal wall.
A disorder characterized by bleeding from esophageal varices.




A disorder characterized by inflammation of the esophageal wall.



A disorder characterized by inability to control the escape of stool from the rectum.




A disorder characterized by a state of excessive gas in the alimentary canal.




A disorder characterized by an abnormal communication between the stomach
and another organ or anatomic site.




A disorder characterized by bleeding from the gastric wall.




A disorder characterized by a necrotic process occurring in the gastric wall.




A disorder characterized by a rupture in the stomach wall.




A disorder characterized by a narrowing of the lumen of the stomach.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the stomach.
A disorder characterized by inflammation of the stomach.

A disorder characterized by reflux of the gastric and/or duodenal contents into the
distal esophagus. It is chronic in nature and usually caused by incompetence of
the lower esophageal sphincter, and may result in injury to the esophageal
mucosal. Symptoms include heartburn and acid indigestion.



A disorder characterized by an abnormal communication between any part of the
gastrointestinal system and another organ or anatomic site.


A disorder characterized by a sensation of marked discomfort in the
gastrointestinal region.




A disorder characterized by an incomplete paralysis of the muscles of the
stomach wall resulting in delayed emptying of the gastric contents into the small
intestine.


A disorder characterized by a sensation of marked discomfort in the gingival
region.




A disorder characterized by bleeding from the hemorrhoids.



A disorder characterized by the presence of dilated veins in the rectum and
surrounding area.




A disorder characterized by an abnormal communication between the ileum and
another organ or anatomic site.




A disorder characterized by bleeding from the ileal wall.
A disorder characterized by blockage of the normal flow of the intestinal contents
in the ileum.




A disorder characterized by a rupture in the ileal wall.




A disorder characterized by a narrowing of the lumen of the ileum.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the ileum.



A disorder characterized by failure of the ileum to transport intestinal contents.




A disorder characterized by bleeding in the abdominal cavity.




A disorder characterized by an abnormal communication between the jejunum
and another organ or anatomic site.




A disorder characterized by bleeding from the jejunal wall.




A disorder characterized by blockage of the normal flow of the intestinal contents
in the jejunum.




A disorder characterized by a rupture in the jejunal wall.
A disorder characterized by a narrowing of the lumen of the jejunum.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the jejunum.



A disorder characterized by a sensation of marked discomfort of the lip.




A disorder characterized by bleeding from the lower gastrointestinal tract (small
intestine, large intestine, and anus).


A disorder characterized by inadequate absorption of nutrients in the small
intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea.




A disorder characterized by inflammation of the oral mucosal.




A disorder characterized by a queasy sensation and/or the urge to vomit.




A disorder characterized by blockage of the normal flow of the contents in the
stomach.




A disorder characterized by an abnormal communication between the oral cavity
and another organ or anatomic site.


A disorder characterized by a burning or tingling sensation on the lips, tongue or
entire mouth.
A disorder characterized by bleeding from the mouth.


A disorder characterized by a sensation of marked discomfort in the mouth,
tongue or lips.




A disorder characterized by a narrowing of the lumen of the pancreatic duct.




A disorder characterized by an abnormal communication between the pancreas
and another organ or anatomic site.




A disorder characterized by bleeding from the pancreas.




A disorder characterized by a necrotic process occurring in the pancreas.




A disorder characterized by inflammation of the pancreas.




A disorder in the gingival tissue around the teeth.




A disorder characterized by a necrotic process occurring in the peritoneum.
A disorder characterized by inflammation of the rectum.




A disorder characterized by an abnormal communication between the rectum and
another organ or anatomic site.




A disorder characterized by bleeding from the rectal wall and discharged from the
anus.




A disorder characterized by inflammation of the mucous membrane of the rectum.




A disorder characterized by a necrotic process occurring in the rectal wall.




A disorder characterized by blockage of the normal flow of the intestinal contents
in the rectum.



A disorder characterized by a sensation of marked discomfort in the rectal region.




A disorder characterized by a rupture in the rectal wall.




A disorder characterized by a narrowing of the lumen of the rectum.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the rectum.
A disorder characterized by bleeding from the retroperitoneal area.




A disorder characterized by inflammation of the salivary duct.




A disorder characterized by an abnormal communication between a salivary gland
and another organ or anatomic site.




A disorder characterized by inflammation of the mucous membrane of the small
intestine.




A disorder characterized by blockage of the normal flow of the intestinal contents.




A disorder characterized by a rupture in the small intestine wall.




A disorder characterized by a narrowing of the lumen of the small intestine.




A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the mucosal surface of the small intestine.



A disorder characterized by a sensation of marked discomfort in the stomach.
A disorder characterized by a pathological process of the teeth occurring during
tooth development.

A disorder characterized by a change in tooth hue or tint.



A disorder characterized by a sensation of marked discomfort in the tooth.




A disorder characterized by inflammation of the cecum.




A disorder characterized by bleeding from the upper gastrointestinal tract (oral
cavity, pharynx, esophagus, and stomach).



A disorder characterized by the reflexive act of ejecting the contents of the
stomach through the mouth.




A disorder characterized by a sensation of cold that often marks a physiologic
response to sweating after a fever.


A disorder characterized by cessation of life occurring during the first 28 days of
life.


A cessation of life that cannot be attributed to a CTCAE term associated with
Grade 5.


A disorder characterized by swelling due to excessive fluid accumulation in facial
tissues.
A disorder characterized by swelling due to excessive fluid accumulation in the
upper or lower extremities.




A disorder characterized by swelling due to excessive fluid accumulation in the
trunk area.



A disorder characterized by a sensation of marked discomfort in the face.


A disorder characterized by a state of generalized weakness with a pronounced
inability to summon sufficient energy to accomplish daily activities.


A disorder characterized by elevation of the body's temperature above the upper
limit of normal.
A disorder characterized by a group of symptoms similar to those observed in
patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite
and dry cough.




A disorder characterized by walking difficulties.
A disorder characterized by an abnormally low body temperature. Treatment is
required when the body temperature is 35C (95F) or below.




A disorder characterized by adverse reaction to the infusion of pharmacological or
biological substances.

A disorder characterized by leakage of a pharmacologic or a biologic substance
from the infusion site into the surrounding tissue. Signs and symptoms include
induration, erythema, swelling, burning sensation and marked discomfort at the
infusion site.



A disorder characterized by an intense adverse reaction (usually immunologic)
developing at the site of an injection.


A disorder characterized by an abnormal responsiveness to stimuli or
physiological arousal; may be in response to pain, fright, a drug, an emotional
situation or a medical condition.




A disorder characterized by swelling due to excessive fluid accumulation at a
specific anatomic site.


A disorder characterized by a feeling of general discomfort or uneasiness, an out-
of-sorts feeling.




A disorder characterized by progressive deterioration of the lungs, liver, kidney
and clotting mechanisms.
A disorder characterized by swelling due to an accumulation of excessive fluid in
the neck.



A disorder characterized by discomfort in the chest unrelated to a heart disorder.


A disorder characterized by the sensation of marked discomfort, distress or
agony.


An unexpected cessation of life that cannot be attributed to a CTCAE term
associated with Grade 5.




A disorder characterized by a narrowing of the lumen of the bile duct.




A disorder characterized by an abnormal communication between the bile ducts
and another organ or anatomic site.



A disorder characterized by inflammation involving the gallbladder. It may be
associated with the presence of gallstones.




A disorder characterized by an abnormal communication between the gallbladder
and another organ or anatomic site.
A disorder characterized by a necrotic process occurring in the gallbladder.




A disorder characterized by blockage of the normal flow of the contents of the
gallbladder.


A disorder characterized by a sensation of marked discomfort in the gallbladder
region.



A disorder characterized by a rupture in the gallbladder wall.


A disorder characterized by the inability of the liver to metabolize chemicals in the
body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin,
lactic dehydrogenase, and alkaline phosphatase.



A disorder characterized by bleeding from the liver.



A disorder characterized by a necrotic process occurring in the hepatic
parenchyma.



A disorder characterized by a sensation of marked discomfort in the liver region.



A disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic
bile duct.


A disorder characterized by an increase in blood pressure in the portal venous
system.


A disorder characterized by the formation of a thrombus (blood clot) in the portal
vein.
A disorder characterized by an adverse local or general response from exposure
to an allergen.




A disorder characterized by an acute inflammatory reaction resulting from the
release of histamine and histamine-like substances from mast cells, causing a
hypersensitivity immune response. Clinically, it presents with breathing difficulty,
dizziness, hypotension, cyanosis and loss of consciousness and may lead to
death.




A disorder resulting from loss of function or tissue destruction of an organ or
multiple organs, arising from humoral or cellular immune responses of the
individual to his own tissue constituents.




A disorder characterized by nausea, headache, tachycardia, hypotension, rash,
and shortness of breath; it is caused by the release of cytokines from the cells.
A disorder characterized by a delayed-type hypersensitivity reaction to foreign
proteins derived from an animal serum. It occurs approximately six to twenty-one
days following the administration of the foreign antigen. Symptoms include fever,
arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort
and dyspnea.




A disorder characterized by an infectious process involving the abdominal cavity.




A disorder characterized by an infectious process involving the anal area and the
rectum.




A disorder characterized by acute inflammation to the vermiform appendix caused
by a pathogenic agent.
A disorder characterized by acute inflammation to the vermiform appendix caused
by a pathogenic agent with gangrenous changes resulting in the rupture of the
appendiceal wall. The appendiceal wall rupture causes the release of
inflammatory and bacterial contents from the appendiceal lumen into the
abdominal cavity.




A disorder characterized by an infectious process involving an artery.




A disorder characterized by an infectious process involving the biliary tract.
A disorder characterized by an infectious process involving the bladder.




A disorder characterized by an infectious process involving the bones.




A disorder characterized by an infectious process involving the breast.




A disorder characterized by an infectious process involving the bronchi.




A disorder characterized by an infectious process that arises secondary to
catheter use.




A disorder characterized by an infectious process involving the cecum.




A disorder characterized by an infectious process involving the uterine cervix.




A disorder characterized by an infectious process involving the conjunctiva.
Clinical manifestations include pink or red color in the eyes.
A disorder characterized by an infectious process involving the cornea.




A disorder characterized by an infectious process involving a cranial nerve.




A disorder characterized by an infectious process involving the use of a medical
device.




A disorder characterized by an infectious process involving the duodenum.




A disorder characterized by an infectious process involving the brain tissue.




A disorder characterized by an infectious process involving the brain and spinal
cord tissues.




A disorder characterized by an infectious process involving the endocardial layer
of the heart.
A disorder characterized by an infectious process involving the internal structures
of the eye.
A disorder characterized by an infectious process involving the small and large
intestines.




A disorder characterized by an infectious process involving the esophagus.




A disorder characterized by an infectious process involving the eye.




A disorder characterized by an infectious process involving the gallbladder.




A disorder characterized by an infectious process involving the gums.




A disorder characterized by an infectious process involving the liver.




A disorder characterized by a viral pathologic process involving the liver
parenchyma.




A disorder characterized by an infectious process involving the skeletal muscles.
A disorder characterized by an infectious process involving a joint.




A disorder characterized by an infectious process involving the kidney.




A disorder characterized by an inflammatory process involving the larynx.




A disorder characterized by an infectious process involving the lips.




A disorder characterized by an infectious process involving the lungs.




A disorder characterized by an infectious process involving the lymph nodes.




A disorder characterized by an infectious process involving the mediastinum.




A disorder characterized by acute inflammation of the meninges of the brain
and/or spinal cord.
A disorder characterized by an infectious process involving a mucosal surface.




A disorder characterized by an infectious process involving the nail.




A disorder characterized by an infectious process involving the outer ear and ear
canal. Contributory factors include excessive water exposure (swimmer's ear
infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling
and marked discomfort in the ear and ear drainage.




A disorder characterized by an infectious process involving the middle ear.




A disorder characterized by an infectious process involving the ovary.




A disorder characterized by an infectious process involving the pancreas.




A disorder characterized by an eruption consisting of papules (a small, raised
pimple) and pustules (a small pus filled blister), typically appearing in face, scalp,
and upper chest and back Unlike acne, this rash does not present with
whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.
A disorder characterized by an infectious process involving the soft tissues around
the nail.




A disorder characterized by an infectious process involving the pelvic cavity.




A disorder characterized by an infectious process involving the penis.




A disorder characterized by an infectious process involving the orbit of the eye.




A disorder characterized by an infectious process involving the peripheral nerves.




A disorder characterized by an infectious process involving the peritoneum.




A disorder characterized by inflammation of the throat.
A disorder characterized by an infectious process involving the vein. Clinical
manifestations include erythema, marked discomfort, swelling, and induration
along the course of the infected vein.




A disorder characterized by an infectious process involving the pleura.




A disorder characterized by an infectious process involving the prostate gland.




A disorder characterized by a circumscribed and elevated skin lesion filled with
pus.




A disorder characterized by an infectious process involving the nasal mucosal.




A disorder characterized by an infectious process involving the salivary gland.




A disorder characterized by an infectious process involving the scrotum.
A disorder characterized by the presence of pathogenic microorganisms in the
blood stream that cause a rapidly progressing systemic reaction that may lead to
shock.
A disorder characterized by an infectious process involving the mucous
membranes of the paranasal sinuses.




A disorder characterized by an infectious process involving the skin.




A disorder characterized by an infectious process involving the small intestine.




A disorder characterized by an infectious process involving soft tissues.




A disorder characterized by an infectious process involving the spleen.




A disorder characterized by an infectious process involving a stoma (surgically
created opening on the surface of the body).




A disorder characterized by an infectious process involving a tooth.




A disorder characterized by an infectious process involving the trachea.
A disorder characterized by an infectious process involving the upper respiratory
tract (nose, paranasal sinuses, pharynx, larynx, or trachea).




A disorder characterized by an infectious process involving the urethra.




A disorder characterized by an infectious process involving the urinary tract, most
commonly the bladder and the urethra.




A disorder characterized by an infectious process involving the endometrium. It
may extend to the myometrium and parametrial tissues.




A disorder characterized by an infectious process involving the vagina.




A disorder characterized by an infectious process involving the vulva.




A disorder characterized by an infectious process involving the wound.
A finding of damage to the ankle joint characterized by a break in the continuity of
the ankle bone. Symptoms include marked discomfort, swelling and difficulty
moving the affected leg and foot.




A finding of damage to the aorta.




A finding of damage to an artery.



A finding of leakage of bile due to breakdown of a biliary anastomosis (surgical
connection of two separate anatomic structures).



A finding of leakage of urine due to breakdown of a bladder anastomosis (surgical
connection of two separate anatomic structures).


A finding of injury of the soft tissues or bone characterized by leakage of blood
into surrounding tissues.

A finding of impaired integrity to the anatomic site of an adverse thermal reaction.
Burns can be caused by exposure to chemicals, direct heat, electricity, flames and
radiation. The extent of damage depends on the length and intensity of exposure
and time until provision of treatment.




A finding of cutaneous inflammatory reaction occurring as a result of exposure to
biologically effective levels of ionizing radiation.
A finding of leakage due to breakdown of an esophageal anastomosis (surgical
connection of two separate anatomic structures).




A finding of sudden movement downward, usually resulting in injury.



A finding of leakage due to breakdown of a fallopian tube anastomosis (surgical
connection of two separate anatomic structures).




A finding of rupture of the fallopian tube wall.




A finding of traumatic injury to the bone in which the continuity of the bone is
broken.



A finding of leakage due to breakdown of a gastric anastomosis (surgical
connection of two separate anatomic structures).



A finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical
connection of two separate anatomic structures).




A finding of a necrotic process occurring in the gastrointestinal tract stoma.




A finding of traumatic injury to the hip in which the continuity of either the femoral
head, femoral neck, intertrochanteric or subtrochanteric regions is broken.




A finding of damage to the carotid artery.
A finding of damage to the inferior vena cava.



A finding of damage to the jugular vein.




A finding of damage to the superior vena cava.



A finding of leakage of contents from an intestinal stoma (surgically created
opening on the surface of the body).




A finding of blockage of the normal flow of the contents of the intestinal stoma.




A finding of blood leakage from the intestinal stoma.




A finding of damage to an artery during a surgical procedure.




A finding of damage to the breast parenchyma during a surgical procedure.



A finding of damage to the heart during a surgical procedure.




A finding of damage to the ear during a surgical procedure.




A finding of damage to the endocrine gland during a surgical procedure.
A finding of damage to the gastrointestinal system during a surgical procedure.




A finding of damage to the head and neck during a surgical procedure.



A finding of uncontrolled bleeding during a surgical procedure.



A finding of damage to the hepatic parenchyma and/or biliary tract during a
surgical procedure.




A finding of damage to the musculoskeletal system during a surgical procedure.




A finding of damage to the nervous system during a surgical procedure.




A finding of damage to the eye during a surgical procedure.




A finding of damage to the kidney during a surgical procedure.




A finding of damage to the reproductive organs during a surgical procedure.




A finding of damage to the respiratory system during a surgical procedure.




A finding of damage to the skin during a surgical procedure.




A finding of damage to the spleen during a surgical procedure.
A finding of damage to the urinary system during a surgical procedure.




A finding of damage to a vein during a surgical procedure.



A finding of leakage of urine due to breakdown of a kidney anastomosis (surgical
connection of two separate anatomic structures).



A finding of leakage due to breakdown of an anastomosis (surgical connection of
two separate anatomic structures) in the large intestine.



A finding of leakage due to breakdown of a pancreatic anastomosis (surgical
connection of two separate anatomic structures).



A finding of leakage due to breakdown of a pharyngeal anastomosis (surgical
connection of two separate anatomic structures).




A finding of bleeding occurring after a surgical procedure.




A finding of a previously undocumented problem that occurs after a thoracic
procedure.




A finding of protrusion of the intestinal stoma (surgically created opening on the
surface of the body) above the abdominal surface.




A finding of displacement of the urostomy.
A finding of acute skin inflammatory reaction caused by drugs, especially
chemotherapeutic agents, for weeks or months following radiotherapy. The
inflammatory reaction is confined to the previously irradiated skin and the
symptoms disappear after the removal of the pharmaceutical agent.



A finding of leakage due to breakdown of a rectal anastomosis (surgical
connection of two separate anatomic structures).




A finding of tumor-like collection of serum in the tissues.



A finding of leakage due to breakdown of an anastomosis (surgical connection of
two separate anatomic structures) in the small bowel.



A finding of leakage due to breakdown of a spermatic cord anastomosis (surgical
connection of two separate anatomic structures).




A finding of traumatic injury to the spine in which the continuity of a vertebral bone
is broken.




A finding of narrowing of the gastrointestinal stoma (surgically created opening on
the surface of the body).


A disorder characterized by a circumscribed, inflammatory and necrotic erosive
lesion on the jejunal mucosal surface close to the anastomosis site following a
gastroenterostomy procedure.




A finding of bleeding from the trachea.
A finding of blockage of the lumen of the trachea.




A finding of blood leakage from the tracheostomy site.



A finding of leakage due to breakdown of a ureteral anastomosis (surgical
connection of two separate anatomic structures).



A finding of leakage due to breakdown of a urethral anastomosis (surgical
connection of two separate anatomic structures).




A finding of leakage of contents from a urostomy.




A finding of blockage of the urostomy.




A finding of bleeding from the urostomy site.




A finding of narrowing of the opening of a urostomy.



A finding of leakage due to breakdown of a uterine anastomosis (surgical
connection of two separate anatomic structures).
A disorder characterized by a rupture in the uterine wall.



A finding of leakage due to breakdown of a vaginal anastomosis (surgical
connection of two separate anatomic structures).



A finding of leakage due to breakdown of a vas deferens anastomosis (surgical
connection of two separate anatomic structures).




A finding of a previously undocumented problem related to the vascular access
site.




A finding of damage to a vein.




A finding of development of a new problem at the site of an existing wound.




A finding of separation of the approximated margins of a surgical wound.



A finding of traumatic injury to the wrist joint in which the continuity of a wrist bone
is broken.
An abnormal laboratory test result in which the partial thromboplastin time is found
to be greater than the control value. As a possible indicator of coagulopathy, a
prolonged partial thromboplastin time (PTT) may occur in a variety of diseases
and disorders, both primary and related to treatment.




A finding based on laboratory test results that indicate an increase in the level of
alanine aminotransferase (ALT or SGPT) in the blood specimen.
A finding based on laboratory test results that indicate an increase in the level of
alkaline phosphatase in a blood specimen.




A finding based on laboratory test results that indicate an increase in the level of
aspartate aminotransferase (AST or SGOT) in a blood specimen.



A finding based on laboratory test results that indicate abnormal levels of
antidiuretic hormone in the blood specimen.
A finding based on laboratory test results that indicate an abnormally high level of
bilirubin in the blood. Excess bilirubin is associated with jaundice.



A finding based on laboratory test results that indicate an decrease in levels of
corticotrophin in a blood specimen.
A finding based on laboratory test results that indicate abnormal levels of
gonadotrophin hormone in a blood specimen.



A finding based on laboratory test results that indicate abnormal levels of prolactin
hormone in a blood specimen.




A finding based on lung function test results that indicate a decrease in the lung
capacity to absorb carbon monoxide.




A laboratory test result which indicates increased levels of cardiac troponin I in a
biological specimen.




A laboratory test result which indicates increased levels of cardiac troponin T in a
biological specimen.
A finding based on laboratory test results that indicate an decrease in levels of
CD4 lymphocytes in a blood specimen.
A finding based on laboratory test results that indicate higher than normal levels of
cholesterol in a blood specimen.
A finding based on laboratory test results that indicate an increase in levels of
creatine phosphokinase in a blood specimen.
A finding based on laboratory test results that indicate increased levels of
creatinine in a biological specimen.


The percentage computed when the amount of blood ejected during a ventricular
contraction of the heart is compared to the amount that was present prior to the
contraction.




A finding of a cardiac dysrhythmia characterized by an abnormally long corrected
QT interval.
A finding based on laboratory test results that indicate an decrease in levels of
fibrinogen in a blood specimen.




A finding based on test results that indicate a relative decrease in the fraction of
the forced vital capacity that is exhaled in a specific number of seconds.

A finding based on laboratory test results that indicate higher than normal levels of
the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-
glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a
gamma glutamyl peptide to another peptide, amino acids or water.



A finding based on laboratory test results that indicate abnormal levels of growth
hormone in a biological specimen.
A finding based on laboratory test results that indicate an decrease in levels of
haptoglobin in a blood specimen.




A finding based on laboratory test results that indicate increased levels of
hemoglobin in a biological specimen.



A finding based on laboratory test results that indicate an increase in the ratio of
the patient's prothrombin time to a control sample in the blood.
A finding based on laboratory test results that indicate an increase in the level of
lipase in a biological specimen.
A finding based on laboratory test results that indicate a decrease in number of
lymphocytes in a blood specimen.

A finding based on laboratory test results that indicate an abnormal increase in the
number of lymphocytes in the blood, effusions or bone marrow.
A finding based on laboratory test results that indicate a decrease in number of
neutrophils in a blood specimen.


A finding based on laboratory test results that indicate an decrease in levels of
pancreatic enzymes in a biological specimen.


A finding based on laboratory test results that indicate a decrease in number of
platelets in a blood specimen.
A finding based on laboratory test results that indicate an increase in the levels of
amylase in a serum specimen.
A finding based on test results that indicate urine production is less relative to
previous output.


A finding based on pulmonary function test results that indicate an abnormal vital
capacity (amount of exhaled after a maximum inhalation) when compared to the
predicted value.


A finding characterized by an increase in overall body weight; for pediatrics,
greater than the baseline growth curve.


A finding characterized by a decrease in overall body weight; for pediatrics, less
than the baseline growth curve.
A finding based on laboratory test results that indicate an decrease in number of
white blood cells in a blood specimen.




A disorder characterized by abnormally high acidity (high hydrogen-ion
concentration) of the blood and other body tissues.
A disorder characterized by an increase in sensitivity to the adverse effects of
alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias,
nausea, vomiting, indigestion and headaches.
A disorder characterized by abnormally high alkalinity (low hydrogen-ion
concentration) of the blood and other body tissues.




A disorder characterized by a loss of appetite.



A disorder characterized by excessive loss of water from the body. It is usually
caused by severe diarrhea, vomiting or diaphoresis.




A disorder characterized by an inability to properly metabolize glucose.
A disorder characterized by laboratory test results that indicate an elevation in the
concentration of calcium in blood.


A disorder characterized by laboratory test results that indicate an elevation in the
concentration of blood sugar. It is usually an indication of diabetes mellitus or
glucose intolerance.
A disorder characterized by laboratory test results that indicate an elevation in the
concentration of potassium in the blood; associated with kidney failure or
sometimes with the use of diuretic drugs.



A disorder characterized by laboratory test results that indicate an elevation in the
concentration of magnesium in the blood.


A disorder characterized by laboratory test results that indicate an elevation in the
concentration of sodium in the blood.



A disorder characterized by laboratory test results that indicate an elevation in the
concentration of triglyceride concentration in the blood.



A disorder characterized by laboratory test results that indicate an elevation in the
concentration of uric acid.


A disorder characterized by laboratory test results that indicate a low
concentration of albumin in the blood.




A disorder characterized by laboratory test results that indicate a low
concentration of calcium in the blood.



A disorder characterized by laboratory test results that indicate a low
concentration of glucose in the blood.



A disorder characterized by laboratory test results that indicate a low
concentration of potassium in the blood.



A disorder characterized by laboratory test results that indicate a low
concentration of magnesium in the blood.
A disorder characterized by laboratory test results that indicate a low
concentration of sodium in the blood.



A disorder characterized by laboratory test results that indicate a low
concentration of phosphates in the blood.



A disorder characterized by accumulation of iron in the tissues.

A disorder characterized by having a high amount of body fat.


A disorder characterized by metabolic abnormalities that result from a
spontaneous or therapy-related cytolysis of tumor cells.




A disorder characterized by a necrotic process occurring in the soft tissues of the
abdominal wall.



A disorder characterized by a sensation of marked discomfort in a joint.




A disorder characterized by inflammation involving a joint.

A disorder characterized by necrotic changes in the bone tissue due to
interruption of blood supply. Most often affecting the epiphysis of the long bones,
the necrotic changes result in the collapse and the destruction of the bone
structure.



A disorder characterized by marked discomfort sensation in the back region.
A disorder characterized by marked discomfort sensation in the bones.



A disorder characterized by marked discomfort sensation in the buttocks.



A disorder characterized by marked discomfort sensation in the chest wall region.




A disorder characterized by non-neoplastic overgrowth of bone.




A disorder characterized by fibrotic degeneration of the deep connective tissues.


A disorder characterized by marked discomfort sensation on the lateral side of the
body in the region below the ribs and above the hip.




A disorder characterized by a reduction in the strength of muscles in multiple
anatomic sites.




A disorder characterized by of stature that is smaller than normal as expected for
age.




A disorder characterized by a necrotic process occurring in the soft tissues of the
head.



A disorder characterized by excessive fluid in a joint, usually as a result of joint
inflammation.
A disorder characterized by a decrease in joint flexibility of any joint.



A disorder characterized by a decrease in flexibility of a cervical spine joint.




A disorder characterized by a decrease in flexibility of a lumbar spine joint.



A disorder characterized by an abnormal increase in the curvature of the thoracic
portion of the spine.



A disorder characterized by an abnormal increase in the curvature of the lumbar
portion of the spine.



A disorder characterized by a reduction in the strength of the muscles on the left
side of the body.




A disorder characterized by a reduction in the strength of the lower limb muscles.



A disorder characterized by a reduction in the strength of the muscles on the right
side of the body.




A disorder characterized by a reduction in the strength of the trunk muscles.




A disorder characterized by a reduction in the strength of the upper limb muscles.
A disorder characterized by of a malformation of the musculoskeletal system.


A disorder characterized by marked discomfort sensation originating from a
muscle or group of muscles.




A disorder characterized by inflammation involving the skeletal muscles.



A disorder characterized by marked discomfort sensation in the neck area.




A disorder characterized by a necrotic process occurring in the soft tissues of the
neck.




A disorder characterized by a necrotic process occurring in the bone of the
mandible.




A disorder characterized by reduced bone mass, with a decrease in cortical
thickness and in the number and size of the trabeculae of cancellous bone (but
normal chemical composition), resulting in increased fracture incidence.


A disorder characterized by marked discomfort sensation in the upper or lower
extremities.




A disorder characterized by a necrotic process occurring in the soft tissues of the
pelvis.
A disorder characterized by a malformed, lateral curvature of the spine.




A disorder characterized by a necrotic process occurring in the soft tissues of the
lower extremity.




A disorder characterized by a necrotic process occurring in the soft tissues of the
upper extremity.




A disorder characterized by fibrotic degeneration of the superficial soft tissues.


A disorder characterized by lack of ability to open the mouth fully due to a
decrease in the range of motion of the muscles of mastication.




A disorder characterized by of a discrepancy between the lengths of the lower or
upper extremities.




-



A disorder characterized by leukemia arising as a result of the mutagenic effect of
chemotherapy agents.
A disorder characterized by insufficiently healthy hematapoietic cell production by
the bone marrow.



A disorder characterized by development of a malignancy most probably as a
result of treatment for a previously existing malignancy.


A disorder characterized by marked discomfort from a neoplasm that may be
pressing on a nerve, blocking blood vessels, inflamed or fractured from
metastasis.




-



A disorder characterized by involvement of the abducens nerve (sixth cranial
nerve).



A disorder characterized by involvement of the accessory nerve (eleventh cranial
nerve).



A disorder characterized by involvement of the acoustic nerve (eighth cranial
nerve).




A disorder characterized by an uncomfortable feeling of inner restlessness and
inability to stay still; this is a side effect of some psychotropic drugs.



A disorder characterized by systematic and extensive loss of memory.
A disorder characterized by the inability to speak. It may result from injuries to the
vocal cords or may be functional (psychogenic).


A disorder characterized by inflammation of the arachnoid membrane and
adjacent subarachnoid space.
A disorder characterized by lack of coordination of muscle movements resulting in
the impairment or inability to perform voluntary activities.



A disorder characterized by regional paresthesia of the brachial plexus, marked
discomfort and muscle weakness, and limited movement in the arm or hand.



A disorder characterized by a necrotic process occurring in the brain and/or spinal
cord.




A disorder characterized by loss of cerebrospinal fluid into the surrounding
tissues.




A disorder characterized by a conspicuous change in cognitive function.




A disorder characterized by a deterioration in the ability to concentrate.




A disorder characterized by a decrease in ability to perceive and respond.




A disorder characterized by a disturbing sensation of lightheadedness,
unsteadiness, giddiness, spinning or rocking.
A disorder characterized by slow and slurred speech resulting from an inability to
coordinate the muscles used in speech.


A disorder characterized by distortion of sensory perception, resulting in an
abnormal and unpleasant sensation.




A disorder characterized by abnormal sensual experience with the taste of
foodstuffs; it can be related to a decrease in the sense of smell.




A disorder characterized by impairment of verbal communication skills, often
resulting from brain damage.


A disorder characterized by swelling due to an excessive accumulation of fluid in
the brain.



A disorder characterized by a pathologic process involving the brain.



A disorder characterized by abnormal, repetitive, involuntary muscle movements,
frenzied speech and extreme restlessness.




A disorder characterized by a reduction in the strength of the facial muscles.



A disorder characterized by involvement of the facial nerve (seventh cranial
nerve).



A disorder characterized by involvement of the glossopharyngeal nerve (ninth
cranial nerve).


A disorder characterized by a sensation of marked discomfort in various parts of
the head, not confined to the area of distribution of any nerve.
A disorder characterized by an abnormal increase of cerebrospinal fluid in the
ventricles of the brain.
A disorder characterized by characterized by excessive sleepiness during the
daytime.



A disorder characterized by involvement of the hypoglossal nerve (twelfth cranial
nerve).




A disorder characterized by bleeding from the cranium.


A disorder characterized by a decrease or absence of blood supply to the brain
caused by obstruction (thrombosis or embolism) of an artery resulting in
neurological damage.



A disorder characterized by involvement of the trochlear nerve (fourth cranial
nerve).


A disorder characterized by a decrease in consciousness characterized by mental
and physical inertness.




A disorder characterized by diffuse reactive astrocytosis with multiple areas of
necrotic foci without inflammation.



A disorder characterized by a deterioration in memory function.


A disorder characterized by neck stiffness, headache, and photophobia resulting
from irritation of the cerebral meninges.
A disorder characterized by uncontrolled and purposeless movements.


A disorder characterized by inflammation involving the spinal cord. Symptoms
include weakness, paresthesia, sensory loss, marked discomfort and
incontinence.


A disorder characterized by intense painful sensation along a nerve or group of
nerves.



A disorder characterized by involuntary movements of the eyeballs.



A disorder characterized by involvement of the oculomotor nerve (third cranial
nerve).



A disorder characterized by involvement of the olfactory nerve (first cranial nerve).

A disorder characterized by functional disturbances of sensory neurons resulting
in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and
warmth that are experienced in the absence of a stimulus.



A disorder characterized by inflammation or degeneration of the peripheral motor
nerves.


A disorder characterized by inflammation or degeneration of the peripheral
sensory nerves.


A disorder characterized by marked discomfort related to a limb or an organ that
is removed from or is not physically part of the body.
A disorder characterized by an episode of lightheadedness and dizziness which
may precede an episode of syncope.

A disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of
the spinal cord. Symptoms include an increase in the muscle tone in the lower
extremities, hyperreflexia, positive Babinski and a decrease in fine motor
coordination.



A disorder characterized by inflammation involving a nerve root. Patients
experience marked discomfort radiating along a nerve path because of spinal
pressure on the connecting nerve root.
A disorder characterized by paralysis of the recurrent laryngeal nerve.
A disorder characterized by headaches, mental status changes, visual
disturbances, and seizures associated with imaging findings of posterior
leukoencephalopathy. It has been observed in association with hypertensive
encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug
treatment. It is an acute or subacute reversible condition.


A disorder characterized by a sudden, involuntary skeletal muscular contractions
of cerebral or brain stem origin.


A disorder characterized by marked discomfort in the face, between the eyes, or
upper teeth originating from the sinuses.


A disorder characterized by characterized by excessive sleepiness and
drowsiness.



A disorder characterized by increased involuntary muscle tone that affects the
regions interfering with voluntary movement. It results in gait, movement, and
speech disturbances.


A disorder characterized by a sudden loss of sensory function due to an
intracranial vascular event.
A disorder characterized by spontaneous loss of consciousness caused by
insufficient blood supply to the brain.



A disorder characterized by a brief attack (less than 24 hours) of cerebral
dysfunction of vascular origin, with no persistent neurological deficit.


A disorder characterized by the uncontrolled shaking movement of the whole body
or individual parts.



A disorder characterized by involvement of the trigeminal nerve (fifth cranial
nerve).




A disorder characterized by involvement of the vagus nerve (tenth cranial nerve).

A disorder characterized by a sudden drop of the blood pressure, bradycardia,
and peripheral vasodilation that may lead to loss of consciousness. It results from
an increase in the stimulation of the vagus nerve.
-


A disorder characterized by death in utero; failure of the product of conception to
show evidence of respiration, heartbeat, or definite movement of a voluntary
muscle after expulsion from the uterus, without possibility of resuscitation.


A disorder characterized by inhibition of fetal growth resulting in the inability of the
fetus to achieve its potential weight.
A disorder characterized by delivery of a viable infant before the normal end of
gestation. Typically, viability is achievable between the twentieth and thirty-
seventh week of gestation.



A disorder characterized by an unexpected pregnancy at the time of conception.




-


A disorder characterized by a state of restlessness associated with unpleasant
feelings of irritability and tension.



A disorder characterized by an inability to achieve orgasm.


A disorder characterized by apprehension of danger and dread accompanied by
restlessness, tension, tachycardia, and dyspnea unattached to a clearly
identifiable stimulus.




A disorder characterized by a lack of clear and orderly thought and behavior.
A disorder characterized by sexual dysfunction characterized by a delay in climax.



A disorder characterized by the acute and sudden development of confusion,
illusions, movement changes, inattentiveness, agitation, and hallucinations.
Usually, it is a reversible condition.




A disorder characterized by false personal beliefs held contrary to reality, despite
contradictory evidence and common sense.




A disorder characterized by melancholic feelings of grief or unhappiness.
A disorder characterized by an exaggerated feeling of well-being which is
disproportionate to events and stimuli.




A disorder characterized by a false sensory perception in the absence of an
external stimulus.




A disorder characterized by difficulty in falling asleep and/or remaining asleep.



A disorder characterized by a decrease in sexual desire.




A disorder characterized by an increase in sexual desire.




A disorder characterized by excitement of psychotic proportions manifested by
mental and physical hyperactivity, disorganization of behavior and elevation of
mood.




A disorder characterized by a conspicuous change in a person's behavior and
thinking.
A disorder characterized by personality change, impaired functioning, and loss of
touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or
brain tumor.



A disorder characterized by an inability to rest, relax or be still.




A disorder characterized by thoughts of taking one's own life.




A disorder characterized by self-inflicted harm in an attempt to end one's own life.




-

A disorder characterized by the acute loss of renal function and is traditionally
classified as pre-renal (low blood flow into kidney), renal (kidney damage) and
post-renal causes (ureteral or bladder outflow obstruction).




A disorder characterized by a rupture in the bladder wall.
A disorder characterized by a sudden and involuntary contraction of the bladder
wall.




A disorder characterized by gradual and usually permanent loss of kidney function
resulting in renal failure.
A disorder characterized by inflammation of the bladder which is not caused by an
infection of the urinary tract.




A disorder characterized by laboratory test results that indicate blood in the urine.



A disorder characterized by laboratory test results that indicate the presence of
free hemoglobin in the urine.




A disorder characterized by laboratory test results that indicate the presence of
excessive protein in the urine. It is predominantly albumin, but also globulin.




A disorder characterized by the formation of crystals in the pelvis of the kidney.



A disorder characterized by paroxysmal and severe flank marked discomfort
radiating to the inguinal area. Often, the cause is the passage of kidney stones.




A disorder characterized by bleeding from the kidney.
A disorder characterized by an abnormal communication between any part of the
urinary system and another organ or anatomic site.




A disorder characterized by urination at short intervals.




A disorder characterized by inability to control the flow of urine from the bladder.




A disorder characterized by accumulation of urine within the bladder because of
the inability to urinate.




A disorder characterized by blockage of the normal flow of contents of the urinary
tract.



A disorder characterized by a sensation of marked discomfort in the urinary tract.




A disorder characterized by a sudden compelling urge to urinate.

A disorder characterized by a change in the color of the urine.




A disorder characterized by laboratory test results that indicate complete absence
of spermatozoa in the semen.
A disorder characterized by underdevelopment of the breast.



A disorder characterized by marked discomfort sensation in the breast region.



A disorder characterized by abnormally painful abdominal cramps during menses.




A disorder characterized by painful or difficult coitus.


A disorder characterized by problems related to ejaculation. This category
includes premature, delayed, retrograde and painful ejaculation.




A disorder characterized by the persistent or recurrent inability to achieve or to
maintain an erection during sexual activity.


A disorder characterized by blockage of the normal flow of the contents in the
fallopian tube.




A disorder characterized by a narrowing of the fallopian tube lumen.



A disorder characterized by an abnormal communication between a female
reproductive system organ and another organ or anatomic site.


A disorder characterized by the development of secondary female sex
characteristics in males due to extrinsic factors.
A disorder characterized by swelling due to an excessive accumulation of fluid in
the genitals.



A disorder characterized by excessive development of the breasts in males.




A disorder characterized by the presence of blood in a fallopian tube.




A disorder characterized by irregular cycle or duration of menses.




A disorder characterized by disturbances of milk secretion. It is not necessarily
related to pregnancy that is observed in females and can be observed in males.




A disorder characterized by abnormally heavy vaginal bleeding during menses.




A disorder characterized by a malformation of the nipple.


A disorder characterized by a decrease in the number of spermatozoa in the
semen.




A disorder characterized by bleeding from the ovary.
A disorder characterized by tearing or disruption of the ovarian tissue.
A disorder characterized by marked discomfort sensation in one side of the
abdomen between menstrual cycles, around the time of the discharge of the ovum
from the ovarian follicle.




A disorder characterized by a reduction in the strength of the muscles of the pelvic
floor.



A disorder characterized by marked discomfort sensation in the pelvis.



A disorder characterized by marked discomfort sensation in the penis.


A disorder characterized by a sensation of marked discomfort in the area between
the genital organs and the anus.

A disorder characterized by ovarian failure before the age of 40. Symptoms
include hot flashes, night sweats, mood swings and a decrease in sex drive.




A disorder characterized by bleeding from the prostate gland.

A disorder characterized by compression of the urethra secondary to enlargement
of the prostate gland. This results in voiding difficulties (straining to void, slow
urine stream, and incomplete emptying of the bladder).


A disorder characterized by a sensation of marked discomfort in the prostate
gland.



A disorder characterized by marked discomfort sensation in the scrotal area.




A disorder characterized by bleeding from the spermatic cord.


A disorder characterized by blockage of the normal flow of the contents of the
spermatic cord.
A disorder characterized by involvement of the testis.




A disorder characterized by bleeding from the testis.



A disorder characterized by a sensation of marked discomfort in the testis.



A disorder characterized by an abnormal communication between the uterus and
another organ or anatomic site.




A disorder characterized by bleeding from the uterus.



A disorder characterized by blockage of the uterine outlet.



A disorder characterized by a sensation of marked discomfort in the uterus.


A disorder characterized by vaginal secretions. Mucus produced by the cervical
glands is discharged from the vagina naturally, especially during the childbearing
years.




A disorder characterized by an uncomfortable feeling of itching and burning in the
vagina.



A disorder characterized by an abnormal communication between the vagina and
another organ or anatomic site.




A disorder characterized by bleeding from the vagina.
A disorder characterized by inflammation involving the vagina. Symptoms may
include redness, edema, marked discomfort and an increase in vaginal discharge.



A disorder characterized by blockage of vaginal canal.



A disorder characterized by a sensation of marked discomfort in the vagina.




A disorder characterized by a rupture in the vaginal wall.




A disorder characterized by a narrowing of the vaginal canal.




A disorder characterized by involuntary spasms of the pelvic floor muscles,
resulting in pathologic tightness of the vaginal wall during penetration such as
during sexual intercourse.




-


A disorder characterized by progressive and life-threatening pulmonary distress in
the absence of an underlying pulmonary condition, usually following major trauma
or surgery.


A disorder characterized by an inflammation of the nasal mucous membranes
caused by an IgE-mediated response to external allergens. The inflammation may
also involve the mucous membranes of the sinuses, eyes, middle ear, and
pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.
A disorder characterized by cessation of breathing.




A disorder characterized by inhalation of solids or liquids into the lungs.




A disorder characterized by the collapse of part or the entire lung.




A disorder characterized by an abnormal communication between the bronchus
and another organ or anatomic site.




A disorder characterized by blockage of a bronchus passage, most often by
bronchial secretions and exudates.
A disorder characterized by a narrowing of the bronchial tube.




A disorder characterized by an abnormal communication between a bronchus and
the pleural cavity.




A disorder characterized by bleeding from the bronchial wall and/or lung
parenchyma.




A disorder characterized by a sudden contraction of the smooth muscles of the
bronchial wall.




A disorder characterized by milky pleural effusion (abnormal collection of fluid)
resulting from accumulation of lymph fluid in the pleural cavity.


A disorder characterized by sudden, often repetitive, spasmodic contraction of the
thoracic cavity, resulting in violent release of air from the lungs and usually
accompanied by a distinctive sound.




A disorder characterized by an uncomfortable sensation of difficulty breathing.
A disorder characterized by bleeding from the nose.



A disorder characterized by repeated gulp sounds that result from an involuntary
opening and closing of the glottis. This is attributed to a spasm of the diaphragm.




A disorder characterized by harsh and raspy voice arising from or spreading to the
larynx.




A disorder characterized by a decrease in the level of oxygen in the body.




A disorder characterized by swelling due to an excessive accumulation of fluid in
the larynx.




A disorder characterized by an abnormal communication between the larynx and
another organ or anatomic site.




A disorder characterized by bleeding from the larynx.



A disorder characterized by an inflammation involving the larynx.
A disorder characterized by an inflammation involving the mucous membrane of
the larynx.




A disorder characterized by blockage of the laryngeal airway.




A disorder characterized by a narrowing of the laryngeal airway.




A disorder characterized by an uncomfortable persistent sensation in the area of
the laryngopharynx.




A disorder characterized by paroxysmal spasmodic muscular contraction of the
vocal cords.




A disorder characterized by bleeding from the mediastinum.


A disorder characterized by obstruction of the nasal passage due to mucosal
edema.
A disorder characterized by an abnormal communication between the pharynx
and another organ or anatomic site.




A disorder characterized by bleeding from the pharynx.




A disorder characterized by an inflammation involving the mucous membrane of
the pharynx.




A disorder characterized by a necrotic process occurring in the pharynx.




A disorder characterized by a narrowing of the pharyngeal airway.


A disorder characterized by marked discomfort sensation in the
pharyngolaryngeal region.




A disorder characterized by an increase in amounts of fluid within the pleural
cavity. Symptoms include shortness of breath, cough and marked chest
discomfort.




A disorder characterized by bleeding from the pleural cavity.
A disorder characterized by marked discomfort sensation in the pleura.




A disorder characterized by inflammation focally or diffusely affecting the lung
parenchyma.




A disorder characterized by abnormal presence of air in the pleural cavity resulting
in the collapse of the lung.


A disorder characterized by excessive mucous secretion in the back of the nasal
cavity or throat, causing sore throat and/or coughing.



A disorder characterized by expectorated secretions upon coughing.




A disorder characterized by accumulation of fluid in the lung tissues that causes a
disturbance of the gas exchange that may lead to respiratory failure.




A disorder characterized by the replacement of the lung tissue by connective
tissue, leading to progressive dyspnea, respiratory failure or right heart failure.




A disorder characterized by an abnormal communication between the lung and
another organ or anatomic site.




A disorder characterized by an increase in pressure within the pulmonary
circulation due to lung or heart disorder.
A disorder characterized by impaired gas exchange by the respiratory system
resulting in hypoxemia and a decrease in oxygenation of the tissues that may be
associated with an increase in arterial levels of carbon dioxide.


A disorder characterized by weight gain, dyspnea, pleural and pericardial
effusions, leukocytosis and/or renal failure originally described in patients treated
with all-trans retinoic acid.




A disorder characterized by involvement of the paranasal sinuses.




A disorder characterized by cessation of breathing for short periods during sleep.



A disorder characterized by the involuntary expulsion of air from the nose.



A disorder characterized by of marked discomfort in the throat




A disorder characterized by a high pitched breathing sound due to laryngeal or
upper airway obstruction.




A disorder characterized by an abnormal communication between the trachea and
another organ or anatomic site.



A disorder characterized by an inflammation involving the mucous membrane of
the trachea.
A disorder characterized by a narrowing of the trachea.




A disorder characterized by a change in the sound and/or speed of the voice.




A disorder characterized by a high-pitched, whistling sound during breathing. It
results from the narrowing or obstruction of the respiratory airways.




-




A disorder characterized by a decrease in density of hair compared to normal for a
given individual at a given age and body location.



A disorder characterized by an abnormal body smell resulting from the growth of
bacteria on the body.
A disorder characterized by inflammation of the skin characterized by the
presence of bullae which are filled with fluid.




A disorder characterized by flaky and dull skin; the pores are generally fine, the
texture is a papery thin texture.




A disorder characterized by target lesions (a pink-red ring around a pale center).




A disorder characterized by generalized inflammatory erythema and exfoliation.
The inflammatory process involves > 90% of the body surface area.




A disorder characterized by shrinking of adipose tissue.




A disorder characterized by the presence of excess hair growth in women in
anatomic sites where growth is considered to be a secondary male characteristic
and under androgen control (beard, moustache, chest, abdomen).




A disorder characterized by excessive perspiration.
A disorder characterized by hair density or length beyond the accepted limits of
normal in a particular body region, for a particular age or race.



A disorder characterized by reduced sweating.




A disorder characterized by hypertrophy of the subcutaneous adipose tissue at the
site of multiple subcutaneous injections of insulin.




A disorder characterized by a change in the color of the nail plate.




A disorder characterized by loss of all or a portion of the nail.




A disorder characterized by vertical or horizontal ridges on the nails.



A disorder characterized by marked discomfort sensation in the skin.
A disorder characterized by redness, marked discomfort, swelling, and tingling in
the palms of the hands or the soles of the feet.




A disorder characterized by swelling due to an excessive accumulation of fluid
around the orbits of the face.




A disorder characterized by an increase in sensitivity of the skin to light.




A disorder characterized by an intense itching sensation.


A disorder characterized by hemorrhagic areas of the skin and mucous
membrane. Newer lesions appear reddish in color. Older lesions are usually a
darker purple color and eventually become a brownish-yellow color.
A disorder characterized by an eruption of papules and pustules, typically
appearing in face, scalp, upper chest and back.




A disorder characterized by the presence of macules (flat) and papules (elevated).
Also known as morbillform rash, it is one of the most common cutaneous adverse
events, frequently affecting the upper trunk, spreading centripetally and
associated with pruritis.


A disorder characterized by marked discomfort sensation in the skin covering the
top and the back of the head.



A disorder characterized by the degeneration and thinning of the epidermis and
dermis.



A disorder characterized by darkening of the skin due to excessive melanin
deposition.




A disorder characterized by loss of skin pigment.




A disorder characterized by an area of hardness in the skin.
A disorder characterized by circumscribed, inflammatory and necrotic erosive
lesion on the skin.




A disorder characterized by less than 10% total body skin area separation of
dermis. The syndrome is thought to be a hypersensitivity complex affecting the
skin and the mucous membranes.



A disorder characterized by local dilatation of small vessels resulting in red
discoloration of the skin or mucous membranes.




A disorder characterized by greater than 30% total body skin area separation of
dermis. The syndrome is thought to be a hypersensitivity complex affecting the
skin and the mucous membranes.




A disorder characterized by an itchy skin eruption characterized by wheals with
pale interiors and well-defined red margins.




-


A disorder characterized by the permanent cessation of menses, usually defined
by 12 consecutive months of amenorrhea in a woman over 45 years of age.
-




-


A disorder characterized by leakage of intravascular fluids into the extravascular
space. This syndrome is observed in patients who demonstrate a state of
generalized leaky capillaries following shock syndromes, low-flow states, ischemia-
reperfusion injuries, toxemias, medications, or poisoning. It can lead to
generalized edema and multiple organ failure.




A disorder characterized by episodic reddening of the face.



A disorder characterized by a localized collection of blood, usually clotted, in an
organ, space, or tissue, due to a break in the wall of a blood vessel.


A disorder characterized by an uncomfortable and temporary sensation of intense
body warmth, flushing, sometimes accompanied by sweating upon cooling.
A disorder characterized by a pathological increase in blood pressure; a
repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg.


A disorder characterized by a blood pressure that is below the normal expected
for an individual in a given environment.



A disorder characterized by the loss of lymph fluid into the surrounding tissue or
body cavity.




A disorder characterized by excessive fluid collection in tissues that causes
swelling.




A disorder characterized by a cystic lesion containing lymph.




A disorder characterized by impaired circulation to an extremity.
A disorder characterized by inflammation of the wall of a vein.
A disorder characterized by a blood clot and inflammation involving a superficial
vein of the extremities.
A disorder characterized by obstruction of the blood flow in the superior vena
cava. Signs and symptoms include swelling and cyanosis of the face, neck, and
upper arms, cough, orthopnea and headache.




A disorder characterized by occlusion of a vessel by a thrombus that has migrated
from a distal site via the blood stream.




A disorder characterized by inflammation involving the wall of a vessel.




A disorder characterized by a decrease in blood supply due to narrowing or
blockage of a visceral (mesenteric) artery.




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