1 Professor David C.Y. Kwan, Ph.D. Department of Medicine, Faculty of Health Sciences McMaster University, Hamilton, Ontario, Canada Dept. Medicine, China Medical Univer. .Taichung, Taiwan Director, Center for Faculty Development Director, Center for International Affairs. Ph.D. (1976) Biol. Chem., Univ. Penn., Phila., Pa., USA M.Sc. (1971) Physic. Chem., Wilkes Univl., Pa. USA B. Sc. (1969) Chemistry, Chu-Hai Coll., Hong Kong Canada’s Who’s Who; Names in Hong Kong (China) Excellent Teaching Assistant Award in Chemistry (1974) Young Investigator Award, Canadian Hypertension Society. (1987) Ontario Heart Foundation Fellowship Awards (1981-1988) Career Investigator Award Canadian Heart & Stroke Foundation. (1989-99) www.kwancy.com Excellent Tutor Award, Undergrad. MD program, McMaster (2002) Assist. Professor (1980); Assoc. Professor (1984); Tenured Full Professor (1988) Professor Kwan is a basic research scientist Prof. Kwan has practiced problem-based specializing in cardiovascular sciences. He was learning (PBL) as a tutor in medical education at originally trained as a physical chemists and McMaster University for nearly two decades. He is an biological chemists during his graduate studies. award-winning tutor and a dedicated PBL advocate. Since 1976, his research interest has spanned across He helped introduce PBL to the medical faculty of the the boundaries of molecular pharmacology, cellular University of Hong Kong since 1994 and a hybrid physiology and natural product research including model of PBL curriculum was launched in 1997 there. Chinese medicine, with an emphasis on cellular In 2000, Prof. Kwan also helped the Faculty of regulation of calcium and cell signaling processes. Medicine of the National University of Singapore He is a founding member of the Smooth Muscle develop a hybrid PBL curriculum. He has traveled Research Program of McMaster University. He also several times to four major medical schools in helped build the Institute of Cardiovascular Sciences Malaysia helping with the development of PBL. He and Medicine at the University of Hong Kong when remains active in the Asia Pacific region towards he was the Chair of Physiology there during 1992- promotion of both medical education and research. He 1996. To this date, Prof. Kwan has published nearly is instrumental in advocating PBL for medical 350 full-length papers (excluding abstracts) education reform in this region spanning from Japan to including 25 book chapters and proceeding papers. Singapore. He also served as a PBL advisor/consultant He has trained numerous research students and for many medical schools in this region. In 2003, he postdoctoral fellows coming from many countries of served as a short-term PBL consultant in the the world. He serves as a member on the Editorial Philippines commissioned by WHO Western Pacific Advisory Board of several international journals. Regional Office in Manila. In 2004, Prof. Kwan spent For >2 decades, He serves as a reviewer for 6-month sabbatical leave as a Visiting Professor of manuscripts, international research granting agencies Andrew T. Huang Fund for Promotion of Medical (Canada, US, Singapore, Hong Kong), graduate Education in Taiwan, where he continues to advocate theses and academic promotions worldwide. He has the benefit of PBL in medical education. He has now been honored with Visiting Professorship in 10 top joined China Medical University in Taiwan and is medical universities in China, the University of actively promoting medical education reform in the Hong Kong, the National University of Singapore, Asia Pacific region, including China. In 2006, he has the National Defense Medical University, Fu-Jen been the speaker on PBL and medical education in Catholic University in Taiwan and University International meetings, such as IUPHAR and FAOPS. Automatic of Central America in Costa Rica. 2 Recent typical publications: Medical Education: Recent typical publications: Biomedical Sciences: 1. Kwan, C.Y. A Barnett, J. Ceaser, A. Cunje, P. 1. Grover AK, Samson SE, Robinson S, Kwan CY.. Gamble, A. Hall and P. Krongold. Learning dynamics Effects of peroxynitrite on sarcoplasmic reticulum in Problem-based Learning (PBL): Perspectives form Ca2+-pump in pig coronary artery smooth muscle. McMaster medical students. J. Med. Edu. (Taiwan) 4 Am J Physiol, 284:C294-301, 2003. (2): 1-9, 2000. 2. Achike FI, Kwan CY. Nitric oxide, human 2. Kwan, C.Y. Medically related cultural issues can diseases and herbal products that act on NO be learned by students and need not be taught by pathway. Clin Expt Physiol Pharmacol 30: 605- teachers in a course. Acad. Medicine, 76:1-3, 2001. 615, 2003. 3. Kwan, C.Y. Is PBL a quality approach to 3. Kwan, CY, Kwan TK, Zhang WB, Sakai Y. In education in health sciences? Ann. Acad. Med. vitro relaxation of vascular smooth muscle by Singapore, 30: 341-346, 2001. atropine: involvement of K+-channels and 4. Kwan C.Y. (tutor), H. Jamal, N. Jha, M. Kapoor, S. endothelium. Naunyn-Schimedeberg’s Arch Katyal, J. Kelly, F. Khan and N. Muhn (mentor) Pharmacol., 368: 1-9, 2003. Problem-based Learning in medicine: the first 12 4. Kwan CY, Zhang WB, Deyama T, Nishibe S. weeks of tutorial. J. Med. Educ. 5: 372-381, 2001. Eucommia aqueous extract induces endothelium- 5. Kwan, C.Y. A note of caution in conducting PBL dependent relaxation in rat aorta and mesenteric tutorials: observations in a medical school that artery. Naunyn-Schmiedeberg’s Arch Pharmacol. newly adopted a PBL curriculum. J. Med. Educ. 5: 369: 206-211,2004. 87-93, 2001. 5. Zheng WB, Chen CX, Sim SM, Kwan CY. In 6. Kwan, C.Y. Problem-based learning: properly vitro vasodilator mechanisms of indole alkaloids, balanced learning? Trends in Pharmacol Sci., rhynchophylline and isorhychophylline, isolated 23:163-164, 2002. from the hook of Uncaria rhychophylla (Miquel). 7. Kwan, C.Y. Problem-based learning and teaching Naunyn-Schmiedeberg’s Arch Pharmacol 369: of medical pharmacology. Naunyn-Schmiedeberg’s 232-238, 2004. Arch. Pharmacol., 366:10-17, 2002. 6. Kwan CY, Zhang WB, Sim SM, Deyama T, 8. Kwan CY. Teaching of human physiology as it Nishibe S. Vascular effects of Siberian ginseng relates to changes in medical education: An Asian (Eleutherococcus senticosus): endothelium- perspective based on the yin-yang principle. J Med dependent NO- and EDHF-mediated relaxation Educ 6: 449-460, 2002. depending on vessel size. Schmiedeberg’s Arch 9. Kwan, C.Y. (tutor), T. Griffin, A. Hosein, K. Pharmacol. 369: 473-480, 2004. Howell, J. Huber-Okrainec Y. Hussain. Students’ 7. Younglai EV, Kwan T, Kwan CY, Lobb DK, perspectives on early clinical exposure during the Foster WG. Dichlorodiphenylchloro-ethylene first twelve weeks of medical education at McMaster elevates cytosolic calcium concentrations and University. J. Med. Educ. 7: 3-14, 2003. oscillations in cultured human granulose cells. 10. Kwan, C.Y. So, you will be a PBL tutor in a Biol Reprod 70: 1693-1700, 2004. medical school. J. Med. Educ. 7: 313-322, 2003. 8. Younglai EV, Wu YJ, Kwan TK, Kwan CY.Non- 11. Kwan, C.Y. Learning of medical pharmacology via genomic action of estradiol and progesterone on innovation: a personal experience at McMaster and cytosolic calcium concentrations in primary in Asia. Acta Pharmacol Sinica 25: 1186-1194, cultures of human granulosa-lutein cells. Hum 2004. Reprod. 20:2383-2390, 2005. 12. Song G, Kwan CY, Bian Z, Tai B, Wu Q. 9. Kwan CY, Zhang WB, Nishibe S, Seo S. A novel Exploratory thoughts concerning educational reform in vitro endothelium-dependent vascular relaxant with problem-based learning in China. Teach Learn effect of Apocynum venetum leaf extract. Med. 17:382-384, 2005. Clin Exp Pharmacol Physiol. 32:789-795, 2005. 13. Kwan CY, Chang YH. PBL: education reform in 10. Davis KA, Samson SE, Best K, Mallhi KK, Chinese and Western medicine. Huaxia Med.1:180- Szewczyk M, Wilson JX, Kwan CY, Grover 182, 2006. AK.Ca(2+)-mediated ascorbate release from 14. Huang C, Bian Z, Tai B, Fan M, Kwan CY. Dental coronary artery endothelial cells. Br J Pharmacol. education in Wuhan, China: challenges and changes. J 147:131-319, 2006. Dent Educ. 71:304-11. 2007 11. Jassen LT, Kwan CY. ROCs and SOCs: what is in a name? Cell Calcium 41: 245-247, 2006.