Aromasin-Exemestane___A_Steroidal_Suicide_Aromatase_Inhibitor

Document Sample
Aromasin-Exemestane___A_Steroidal_Suicide_Aromatase_Inhibitor Powered By Docstoc
					Title:
Aromasin-Exemestane – A Steroidal Suicide Aromatase Inhibitor

Word Count:
399

Summary:
Aromasin-Exemestane is a steroidal suicide aromatase inhibitor that
depresses estrogen fabrication within the human body by deflecting the
aromatase enzyme, which is responsible for estrogen synthesization.
Initially, Aromasin-Exemestane was originated to fight breast cancer in
post-menopausal women those who want a particularly belligerent medical
aid, and for whom first line defensive measure such as SERMS (Tamoxifen)
have not worked in an effectual manner. Aromasin-Exemestane is pretty
substantial, or at least more accented than other chemical compounds used
to fight breast cancer.


Keywords:
Aromasin-Exemestane


Article Body:
Aromasin-Exemestane is a steroidal suicide aromatase inhibitor that
depresses estrogen fabrication within the human body by deflecting the
aromatase enzyme, which is responsible for estrogen synthesization.
Initially, Aromasin-Exemestane was originated to fight breast cancer in
post-menopausal women those who want a particularly belligerent medical
aid, and for whom first line defensive measure such as SERMS (Tamoxifen)
have not worked in an effectual manner. Aromasin-Exemestane is pretty
substantial, or at least more accented than other chemical compounds used
to fight breast cancer.

Aromasin-Exemestane is a prescription drug for postmenopausal women who
have had estrogen-receptor positive early breast cancer. Treatment with
Aromasin-Exemestane should carry on for 2 to 3 years till the completion
of a total of 5 years of adjuvant cure with both Tamoxifen as well as
Aromasin-Exemestane.

Aromasin-Exemestane is a permanent, steroidal aromatase demobilizer,
structurally linked to the natural substratum androstenedione. It
functions as a false substrate for the aromatase enzyme, and is litigated
to an average, which bonds in an irreversible manner to the active site
of the enzyme causing its deactivation, a consequence also called suicide
inhibition.

Aromasin-Exemestane considerably turns down circulating estrogen
densities in postmenopausal women, but has no noticeable upshot on
adrenal biosynthesis of corticosteroids or aldosterone. It has no effect
on other enzymes that are involved in the steroidogenic tract up to a
density at least 600 times greater than that suppressing the aromatase
enzyme.
The common side-effects linked with <a
href=http://www.isteroids.com/steroids/Aromasin-
Exemestane.html/>Aromasin-Exemestane</a> are hot flashes, upset stomach,
feeling tired, nausea, increased sweating, increased appetite, gyno,
acne, water-retention, insomnia and joint pain. Aromasin-Exemestane may
reduce the bone mineral density (BMD) over time. A few women who
participated in the AROMASIN IES analysis developed osteoporosis, and
there was also a risk of fractures.

For oral administration, Aromasin-Exemestane tabs have 25 mg of
exemestane, which is a permanent steroidal aromatase inactivator.
The inactive ingredients contained by each Aromasin-Exemestane pill
include microcrystalline cellulose, methylparaben, sodium starch
glycolate, polysorbate 80, magnesium carbonate, hypromellose, sucrose,
mannitol, titanium dioxide, glycol 6000, magnesium stearate, simethicone,
crospovidone, colloidal silicon dioxide, polyethylene, and polyvinyl
alcohol.

Aromasin-Exemestane should not be taken in pregnancy. Aromasin-Exemestane
should not be used, unless the women have gone through menopause.
Aromasin-Exemestane should not be taken with a medicine that has
estrogen. It is also important for the patients to discuss their medical
history or any other medications or supplements that they are already
taking, with the medical specialist.
st.

				
DOCUMENT INFO